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Background: Leaves of the plant Ipomea marginata is commonly used in Indian folklore medicine to treat skin infections however the antibacterial property of Ipomea marginata against oral microorganisms causing gingivitis and periodontitis has not been explored till date. Hence, the present study is planned to compare and evaluate the antibacterial efficacy of ethanolic extract of Ipomea marginata with 0.2% chlorhexidine mouth wash on select oral microorganisms. Materials and Methods: Phytochemical screening of ethanolic extract of leaves of Ipomea marginata showed significant levels of secondary metabolites accountable for the antibacterial property of the leaves. Identification of the volatile constituents of the leaves of Ipomea margianta was carried out using GC-MS and nine volatile compounds were identified. Antibacterial activity of ethanolic extract of Ipomea marginata was evaluated against S. mutans, T. denticola, T. forsythia and P. gingivalis which are the chief organisms indicated in the etiology of plaque induced gingivitis. The zone of inhibition and minimum inhibitory concentration was determined by disc diffusion and broth dilution method respectively and compared with gold standard 0.2% chlorhexidine. Time kills kinetics of test pathogens at 6, 12, 18 and 24 hr was also determined. The herbal extract exhibited statistically significant antibacterial property compared to standard chlorhexidine by agar disc diffusion method. Results: The Minimum Inhibitory Concentration (MIC) for the herbal extract for S. mutans, P. gingivalis, T. denticola and T. forsythia was 6.25 µg/mL, 100 µg/mL, 100 µg/mL and 50 µg/mL, respectively and for 0.2% chlorhexidine it was 25 µg/mL, 12.5 µg/mL, 200 µg/mL and 100 µg/mL respectively. Time kills kinetics revealed bactericidal activity of ethanolic extract of Ipomea marginata against oral microorganisms causing gingivitis in a time dependent manner. Conclusion: Ethanolic extract of leaves of Ipomea marginata showed promising antibacterial activity compared to standard 0.2% chlorhexidine mouth wash. [ABSTRACT FROM AUTHOR]

Echinacea angustifolia due to its antibacterial properties is routinely used in homoeopathy for treating blood poisoning and upper respiratory tract infections. In this study Echinacea angustifolia mouthwash was used to reduce the pain and bacterial growth in patients with pharyngitis. Methods and materials: 15 patients suffering from pharyngitis were selected, and were prescribed the Echinacea angustifolia aqueous mouth wash. The patients were advised to rinse their mouth: twice a day for four days. We collected throat swabs, before and after intervention for culturing the bacteria. We estimated the magnitude of the pain due to pharyngitis using the verbal analog pain scale, and used this data for assessing whether the mouth wash is effective in reducing the pain. We performed paired t test to prove the effectiveness. Result: We found no evidence of anti-bacterial activity against any bacteria cultured from the patients, (p>0.05). Nevertheless, we found the evidence of mouth wash reducing the pain due to pharyngitis. The mean value of the pain reduced from 6.23 to 0.93. (p<0.001). [ABSTRACT FROM AUTHOR]

Rinsing the mouth with a carbohydrate (CHO) solution has been shown to enhance exercise performance while reducing neuromuscular fatigue. This effect is thought to be mediated through the stimulation of oral receptors, which activate brain areas associated with reward, motivation, and motor control. Consequently, corticomotor responsiveness is increased, leading to sustained levels of neuromuscular activity prior to fatigue. In the context of endurance performance, the evidence regarding the central involvement of mouth rinse (MR) in performance improvement is not conclusive. Peripheral mechanisms should not be disregarded, particularly considering factors such as low exercise volume, the participant's fasting state, and the frequency of rinsing. These factors may influence central activations. On the other hand, for strength-related activities, changes in motor evoked potential (MEP) and electromyography (EMG) have been observed, indicating increased corticospinal responsiveness and neuromuscular drive during isometric and isokinetic contractions in both fresh and fatigued muscles. However, it is important to note that in many studies, MEP data were not normalised, making it difficult to exclude peripheral contributions. Voluntary activation (VA), another central measure, often exhibits a lack of changes, mainly due to its high variability, particularly in fatigued muscles. Based on the evidence, MR can attenuate neuromuscular fatigue and improve endurance and strength performance via similar underlying mechanisms. However, the evidence supporting central contribution is weak due to the lack of neurophysiological measures, inaccurate data treatment (normalisation), limited generalisation between exercise modes, methodological biases (ignoring peripheral contribution), and high measurement variability. Trial registration: PROSPERO ID: CRD42021261714. The graphic depicts the main findings of the review and the benefits of MR on endurance and strength performance respectively. The figure also shows factors affecting MR response. TT Time trial, TTE Time to exhaustion, ISO-M Isometric contraction, ISO-K Isokinetic contraction, MR Mouth rinse [ABSTRACT FROM AUTHOR]

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This article discusses a study on the effects of surface treatments and mouthwash on the bond strength of temporary restorative materials. The study found that sandblasting increased bond strength, while hydrofluoric acid etching decreased it. The type of cement used and the presence of mouthwash also had varying effects on bond strength. The study suggests that the choice of material and cement should be made carefully, taking into account their compatibility and the potential interaction with mouthwash. The study also highlights the importance of considering other factors that can affect bond strength and recommends using specific surface treatments and materials for better results. However, it should be noted that the study was conducted in vitro and further research is needed. This information can be useful for researchers and dental professionals studying and selecting materials for dental procedures. [Extracted from the article]

This systematic review and network meta-analysis (NMA) comprehensively compared the effectiveness of different mouth rinses in reducing the viral load/infectivity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) (Part I), alleviating clinical symptoms or severity of disease (Part II), and decreasing the incidence of SARS-CoV-2 infection (Part III). Randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) with restrictions were searched up to 3rd March 2023. Twenty-three studies (22 RCTs and one NRCT) met the inclusion criteria for this systematic review. Five RCTs (454 patients and nine interventions) in Part I were eligible for NMA. The NMA results showed that, in comparison with no rinse, sodium chloride (NaCl) was the most effective mouth rinse for reducing the viral load, followed by povidone-iodine (PVP-I), ß-cyclodextrin + citrox (CDCM), hydrogen peroxide (HP), chlorhexidine gluconate (CHX), cetylpyridinium chloride (CPC), placebo and hypochlorous acid (HClO). However, these results were not significant. Based on surface under the cumulative ranking curve scores, PVP-I was likely to be the most efficacious mouth rinse for reducing SARS-CoV-2 viral load, followed by CDCM, HP, NaCl, CHX, CPC, placebo, no rinse and HClO. Due to heterogeneity of the primary studies, the effectiveness of different mouth rinses to reduce viral infectivity, improve clinical symptoms or prevent SARS-CoV-2 infection remains inconclusive. [ABSTRACT FROM AUTHOR]

BackgroundStomatitis is a frequent dose limiting toxicity of everolimus, an approved therapy for patients with metastatic breast cancer. No randomized trials of a prophylactic measure to prevent mucositis have been reported.MethodsWe conducted a phase II, open-label trial in which patients with metastatic breast cancer starting everolimus were randomized to best supportive care (BSC) versus prophylactic use of an oral mucoadhesive, non-steroid containing mouth wash. The primary endpoint was rate of any grade stomatitis as reported by the treating physicians. Secondary endpoints were severity of stomatitis according to the Oral Mucositis Assessment Scale (OMAS) and rates of everolimus dose reduction or discontinuation due to mucositis.ResultsOf 61 evaluable patients, 32 were randomized to and treated with oral mucoadhesive and 29 with BSC. Any grade stomatitis developed in 46.9% (15/32) of study arm and 65.5% (19/29) of BSC arm patients (p = 0.14). The difference between the two arms was significantly in favor of the mucoadhesive arm when mucositis was scored according to the OMAS with average score of 0.3 in study arm versus 0.5 in the control arm (p = 0.03). There were fewer dose adjustments or therapy discontinuations in the study arm compared with BSC (16% versus 31%, respectively) but the difference did not reach statistical significance.ConclusionHere we provide early evidence from the first randomized trial supporting the use of oral prophylactic mucoadhesive for everolimus-associated stomatitis. A trial comparing prophylactic oral mucoadhesive to steroid mouth wash may be warranted.

Oral ulcers are common occurrences in animals for many reasons, including accidental injuries that occur during the consumption of feed or food, and may be bacterial and fungal or viral causes such as foot-and-mouth disease, which is usually accompanied by ulcers in the mouth, udder and foot (FMD), which leads to the animal's abstinence from food and then death so to find ways that solve this problem a pharmaceutical formula had been prepared from extract oils mint, thyme and cloves called it (mint vet). The oils were extracted by water evaporation then examined by GC-MS and attended many formulations until reaching the until reaching the perfect consistency and stability where the pharmaceutical form was white emulsion kept inside a spray bottle given in the form of a mouthwash. The biological test stability was conducted on the product for six months at two temperatures one of them cold degree 4°C and the other is room temperature 25°C to determine the expiration date and the best storage conditions, it has been compare with stander Gentamicin and Nystatin the inhibition zone of formula was higher than stander inhibition zone, high temperature was avoided because the product contains essential oil, the expiry date was calculated two years and store at less 15°C. The formula has been tasted in veterinary hospitals in Al-Rashedia and Baghdad, the report had proved the efficiency of the mouth wash and there are significant responses, when it’s used to treat Foot and Mouth Disease FMD without any side effect.

Objective: This randomized controlled trial (RCT) aims to investigate the short‐term effects of chlorhexidine mouthwash (MW) on gingival health surrounding orthodontic miniscrew implants (OMIs) and their overall survivability. Materials and Methods: Thirty‐two participants (mean age, 22.8 years) undergoing fixed orthodontic appliance treatment after maxillary premolar extraction were randomly allocated in a parallel fashion to either receive (1) MW with an active component of chlorhexidine or (2) a placebo. Each participant received two maxillary buccal OMIs for anchorage reinforcement purposes. Participants were assessed for their gingival oral health status around all inserted OMIs and had their OMI survivability recorded at three time points; T1 = 1 month, T2 = 3 months, and T3 = 6 months after OMI placement. A Kaplan‐Meier plot was used to estimate the survival function of OMIs. Results: All randomized participants completed the follow‐up period. In terms of gingival oral health, there were no statistically significant differences at any time point between the chlorhexidine MW group and the placebo‐controlled group (P >.05). One OMI was lost in the chlorhexidine MW group and another two OMIs in the control group. There was no significant difference between both groups in terms of survivability (P =.585). Conclusion: The use of chlorhexidine MW does not seem to have a significant clinical impact on gingival health around OMIs or their survivability in this pilot study. [ABSTRACT FROM AUTHOR]

Background: Carbohydrate (CHO) mouth rinse has been used as an ergogenic strategy due to its central effect; however, the effects of this intervention during short-duration high-intensity exercises are not fully understood. Purpose: To investigate the effect of CHO mouth rinse on time to exhaustion in a short-duration high-intensity exercise performed on a treadmill. Methods: A randomized double-blind, placebo-controlled, crossover study was conducted with 10 (24.1 [4.3] y) recreationally active male runners. The protocol consisted of a warm-up at 65% of VO2max for 5 min followed by 3 min passive rest. At the end of this rest period, the individuals performed their mouth rinse either with CHO (maltodextrin, 6%) or with placebo (industrialized noncaloric juice with the same taste). Immediately after mouth rinse, the subjects ran at velocity equivalent to 100% of individual VO2max until voluntary exhaustion. The perceived effort was obtained through a Borg scale. Blood lactate was quantified before and after the protocol, and heart rate was evaluated during the protocol. Results: No difference was found (P = .90) in time to exhaustion between placebo (193.9 [46.5] s) and CHO mouth rinse (195.1 [51.8] s). Blood lactate, heart rate, and perception of effort increased in both groups, but with no differences (all variables, P > .05) between groups. Conclusion: The findings showed that a preexercise single-CHO mouth rinse was ineffective to improve running time to exhaustion at velocity equivalent to 100% VO2max on a treadmill in recreationally active male runners. [ABSTRACT FROM AUTHOR]

One of the chemical control treatment of plaque and gingivitis as a support for the mechanical control treatments is the use of mouthwash. The main strength of herbal-based mouthwash is no side effects are known and it does not contain any alcohol or sugar. White tea and black tea are tea products that are known to contain catechins and phenols, both of which have the ability to fight and prevent the growth of microorganisms. This study aims to identify the efficacy of using herbal mouthwash based on white tea and black tea extracts against plaque and gingivitis. This research was conducted using a rapid review method which refers to a systematic literature review through the PICO framework based on Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Literature searches were performed using PubMed, Science Direct, Cochrane, Garuda, and Google Scholar. There are 10 articles in total with RCT, true experiment, and quasyexperiment research designs obtained based on the inclusion criteria to be analyzed qualitatively. Experimental research on 10 articles with a period of one day to one month showed that gargling with white tea and black tea extracts mouthwash can reduce plaque, gingival inflammation, and inhibit bacteria (Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans). In conclusion, gargling using white tea and black tea extract mouthwash can reduce plaque, reduce gingival inflammation, and inhibit bacteria such as Porphyromonas gingivalis, Prevotella intermedia, and Aggregatibacter actinomycetemcomitans. [ABSTRACT FROM AUTHOR]

Aims: Applying mouthwash has an important role in reducing caries when compared to other prevention methods. The purpose of this study is to compare saliva pH and plaque index before and after using chlorhexidine mouthwash and a mouthwash with green tea extract. Materials and Methods: Forty dental students were randomly assigned to two groups (chlorhexidine and green tea mouthwash). A week before research getting started and during that, the students were asked to use normal diet and Bass brushing method. Salivary pH and plaque index of the participants were measured before, 1 week, and also 2 weeks after the use of mouth washes. Then, the data were analyzed based on Friedman, Mann–Whitney, and repeated-measures ANOVA tests. Results: The mean pH was significantly different in the three times of 1 week prior, during, and 2 week after the treatment for the green tea group (P = 0.01). However, there was no significant difference in the chlorhexidine group (P = 0.211). The mean of new plaque in both chlorhexidine green tea groups was significant (P < 0.001). The mean of plaque formation at

Background/Aim: Acid-electrolyzed functional water (FW) is an efficient bactericide and gargling with FW might be an effective method of oral care. We investigated the possible use of FW as a mouth wash by an in vitro study. Materials and Methods: The bactericidal effect of FW against different species of bacteria (Staphylococcus aureus, Streptococcus pneumonia, Pseudomonas aeruginosa, and Candida albicans) was evaluated using the numbers of colony-forming units (CFU). The experiment was conducted using PBS, LISTERINE, and ConCool F (undiluted, and the optimal concentration indicated). To investigate the bactericidal mechanism of FW, the activity of superoxide dismutase (SOD), an indicator of oxidative action, was measured in S. aureus. FW was diluted with purified water to concentrations of 10, 30, 50, and 70%. The numbers of CFU were measured for each concentration. XTT assays were performed using HSC-3 and HeLa cells, to examine the viability of the cells following treatment with FW. The same experiment was conducted with PBS, LISTERINE, and undiluted ConCool F. Results: No bacteria treated with FW formed colonies. SOD activity peaked at a 50% concentration of FW and was more than twice that of the control. A significant decrease in the number of CFU was observed following 50% treatment. Since the peaks of the SOD activity and the starting concentrations of the bactericidal effects coincided, the bactericidal effect of FW might be related to its oxidative effects. Bacteria treated with FW had the same survival rate as the other mouth washes. Conclusion: FW might be clinically applicable as a mouth wash. [ABSTRACT FROM AUTHOR]

Aims and Objective: Sugar is not only associated with dental diseases but also, along with carbohydrates, is linked to various health issues including obesity, cancer, diabetes, heart, liver, and kidney-related diseases. At the same time, a polyphenol present in unrefined sugar and starch (UReSS) is shown to inhibit microbial growth and prevent biofilms and dental plaque. The question arises, "is sugar the causative agent for dental diseases, or is its refined form the cause?" The objective of this study is to conduct in-vivo studies of the impact of refined and unrefined sugar and starch on the microbiota of dental biofilm. Materials and Methods: An in-vivo study was performed using saliva and dental biofilm samples collected from 75 healthy subjects. For this study, healthy volunteers (n = 75) were randomly divided into five groups and were given sweet meals either made with refined white sugar and white rice (ReSS) or with unrefined brown sugar and red rice (UReSS). This was followed by using or not using a polyphenolic mouthwash. Before and after 4 h of eating a sweet meal, the saliva and dental plaque were collected and the DNA was analyzed by 16s metagenomic sequencing. The results were expressed in fold change of bacteria from 0 to 4 h. Statistical analyses have been performed by logarithmic linear discriminant analysis (LDA), Student's t-test, and Wilcoxon signed-rank test. Results: Upon LEfSe and statistical analysis, in-vivo experiments clearly showed that UReSS significantly decreased bacteria associated with dental diseases. In contrast, ReSS showed a significant increase in Actinomyces, Streptococcus, and Selenomonas with a high LDA score (Log 4.2) and statistical significance (P < 0.003). Mouthwash significantly decreased bacterial taxa associated with diseases in both the ReSS and UReSS groups. The in-vivo study showed a significant increase and decrease in Streptococcus levels in refined and unrefined sugar groups, respectively. Conclusion: In conclusion, polyphenols aid in the prevention of dental caries. This study recommends using polyphenol-rich unrefined sugars and carbohydrates for both oral and general health. This study is the first of its kind to bring awareness to the effects of refined and unrefined starch and sugars on the oral microbiota. [ABSTRACT FROM AUTHOR]

Green, MS, Kimmel, CS, Martin, TD, Mouser, JG, and Brune, MP. Effect of carbohydrate mouth rinse on resistance exercise performance. J Strength Cond Res 36(7): 1916–1921, 2022—A carbohydrate mouth rinse (CMR) has been shown to enhance short duration endurance performance and raises the possibility that a similar strategy could improve performance during resistance exercise. Eighteen male and female (N = 36) resistance trained subjects (mean values ± SD ; age: 21.5 ± 1.6 years, height: 1.72 ± 0.09 m, body mass: 72.8 ± 13.4 kg, and body fat: 16.7 ± 5.8%) performed 3 experimental visits during which bench press resistance exercise (4 × 10 repetitions at 65% of 1 repetition maximum [1RM] with 120 seconds recovery) and repetitions to failure at 60% 1RM were performed. Subjects rinsed 25 ml of water (WAT), noncaloric placebo (PLA), or 6.4% maltodextrin (CHO) solution for 10 seconds during exercise in a crossover, counter-balanced manner. Rating of perceived exertion (RPE), pleasure-displeasure (FS), number of repetitions to fatigue (REPS), and postexercise blood glucose (GLU) and lactate (LA) were measured. Compared to WAT (17.7 ± 0.8), PLA (19.0 ± 0.7; p = 0.025), and CHO (18.7 ± 0.8; p = 0.039) treatments resulted in higher REPS, with no difference between PLA and CHO treatments (p = 0.310). Rating of perceived exertion progressively increased each set (p < 0.0001), but was not affected by treatment (p = 0.897). Pleasure-displeasure declined during recovery from sets 3 and 4 (p < 0.05) but was also not affected by treatment (p = 0.692). Postexercise GLU (p = 0.103) and LA (p = 0.620) were not different between treatments. Although a placebo effect was present for REPS, this study failed to detect an effect of CMR on REPS, RPE, FS, GLU, or LA on upper-body resistance exercise. [ABSTRACT FROM AUTHOR]

Aim: To evaluate the effectiveness of Miswak in comparison with standard caries preventive measures for the prevention of new carious lesions in high caries risk patients. Materials and Methods: In this randomized control clinical trial, 26 participants per group of dental students aged from 18 to 25 years were recruited with high caries risk based on sample size calculation. The DMF score was determined. Plaque index was recorded at baseline and after 1 year. Participants were randomized into one control group and two intervention groups. The control group (Group 1) used the standard oral hygiene measures. Group 2 used Miswak only, whereas Group 3 used Miswak plus toothbrush and toothpaste. Data were collected and statistically analyzed with the significance level set at P ≤ 0.05 within all tests. Results: Caries risk assessment revealed that at baseline, there was no statistically significant difference in plaque index score distribution between the different study groups (P = 0.532). At baseline, there was no statistically significant difference in DMF counts distribution between the different study groups (P = 0.268 in D counts, and P = 0.268 in F counts). There were no new lesions detected in all groups at different evaluation times. Conclusions: Using Miswak as a natural product solely is as effective and safe as using the standard oral hygiene measures combined. The use of a time-saving preventive regimen could be promising for the compliance of the high caries risk population. [ABSTRACT FROM AUTHOR]

Patients undergoing Radiotherapy (RT) for Head and Neck carcinoma often suffer from side effects such as mucositis, xerostomia, pharyngitis, laryngitis and pain which are being managed symptomatically by mouthwashes of soda-salt, chlorhexidine or betadine. Among the side effects, oral mucositis is the most debilitating one. This comparative case study comprises of 4 patients undergoing RT. Here, 2 patients each are randomly allocated into two groups. One group received the existing prophylactic management i.e., Sodium bicarbonate-salt solution mouth wash and the other group received, Draksha-guduchyadi yoga for kavala (gargling). Both the sets of patients were asked to perform gargling, from the first day of radiation to 15 days thereafter. The effectiveness of both mouthwashes was compared for their healing potential on oral mucositis by RTOG grading. The reduction in mucositis was significant in the group which received Ayurvedic mouthwash compared to the other group. This study positively highlights the contribution of Ayurveda in cancer treatment especially in the field of quality of life.

• Mouthwash presents a sufficient collection method for detecting SARS-CoV-2. • Buccal swabbing does not present a sufficient collection method for detecting SARS-CoV-2 due to low sensitivity. • Mouthwash is better tolerated by patients especially children that nasopharyngeal swabbing. • Viral load of SARS-CoV-2 is highest in the first week of disease in mouthwash, buccal swab and nasopharyngeal swab. The use of nasopharyngeal (NP) swabs as a specimen collection method to diagnose SARS-CoV-2 infection is frequently perceived as uncomfortable by patients and requires trained personnel. In this study, detection rate of SARS-CoV-2 in mouthwash samples and buccal swabs were compared in both children and adults. In patients admitted to hospital with confirmed COVID-19 within the previous 72 hours, NP and buccal swabs as well as mouthwash samples were collected. RT-qPCR was performed on all samples. In total, 170 samples were collected from 155 patients (137 adults and 18 children). Approximately 91.7% of the collected NP swabs were positive in RT-PCR compared to 63.1% of mouthwash samples and 42.4% of buccal swabs. Compared to NP swabs, the sensitivity of using mouthwash was 96.3% and 65.4% for buccal swabs in NP swab samples with a CT value <25. With increasing CT values, sensitivity decreased in both mouthwash and buccal swabs. The virus load was highest during the first week of infection, with a continuous decline observed in all three collection methods over time. Mouthwash presents an alternative collection method for detecting SARS-CoV-2 in the case of unfeasible NP swab sampling. Buccal swabs should not be used due to their low sensitivity. [ABSTRACT FROM AUTHOR]

Aims: Applying mouthwash has an important role in reducing caries when compared to other prevention methods. The purpose of this study is to compare saliva pH and plaque index before and after using chlorhexidine mouthwash and a mouthwash with green tea extract. Materials and Methods: Forty dental students were randomly assigned to two groups (chlorhexidine and green tea mouthwash). A week before research getting started and during that, the students were asked to use normal diet and Bass brushing method. Salivary pH and plaque index of the participants were measured before, 1 week, and also 2 weeks after the use of mouth washes. Then, the data were analyzed based on Friedman, Mann–Whitney, and repeated-measures ANOVA tests. Results: The mean pH was significantly different in the three times of 1 week prior, during, and 2 week after the treatment for the green tea group (P = 0.01). However, there was no significant difference in the chlorhexidine group (P = 0.211). The mean of new plaque in both chlorhexidine green tea groups was significant (P < 0.001). The mean of plaque formation at <48 h in chlorhexidine and in green tea was both significant (P < 0.001). Conclusion: The effect of chlorhexidine mouthwash and green tea on salivary pH and plaque index was the same in a week. However, the effect of green tea was more than that of chlorhexidine in a 3-week application. [ABSTRACT FROM AUTHOR]

Introduction: Unpleasant odor emitted from the oral cavity of a person is called halitosis. The other common terminologies that are used to refer to halitosis are fetor oris, oral malodor, or bad breath. Materials and Method: An online survey was conducted, with a set of 15 questions among dental undergraduate students of Saveetha Dental College to assess their knowledge, attitude and practices regarding self-perceived halitosis. Google forms were used to conduct the survey. The results of the survey were collected and tabulated. SPSS by IBM was used to analyze the data, the frequency and percentage of each question was extracted. The statistical test used was Chi Square test. Results: 84.5% of the study participants did not have any feeling of bad breath. 82% of them were aware that systemic diseases and conditions could cause oral malodor. 78.7% of them knew it may be attributed to gum disease. 60.5% of them brushed only once a day, 70.7% of them used mouthwash regularly, 83.9% of them used tongue cleaner and 52.3% of them flossed regularly. 60.3% of them did not go for a professional cleaning or check up. Conclusion: From the study we conclude that there is a fair amount of knowledge about halitosis and ways to prevent and measures to avoid halitosis. People were also aware of the behavior with people affected from halitosis, there is a need to create awareness on halitosis and ways to avoid halitosis and preventive measures to be taken for halitosis, professional cleaning. [ABSTRACT FROM AUTHOR]

Purpose: The scope of this research endeavor was the determination of the applicability of over the counter mouthwash solutions in reducing the viral load in the saliva of COVID-19 patients and hence decreasing their infectivity. Beyond that, new experimental mouthwashes were investigated in terms of a possible positive immune modulation, which might offer an additional opportunity for a positive pharmaceutical effect. Methods: The effectivity of the mouth washing solution was determined on 34 hospitalized COVID-19 patients by measuring the viral load by RT-qPCR in pharyngeal swabs, which were taken before and after rinsing. The inflammatory modulation thru the experimental solutions was assayed in an in vitro model of virus infected nasopharyngeal epithelium cells. Results: The clinical pilot study demonstrated that the mouth rinsing solution was able to reduce the viral load by about 90% in the saliva of most patients. This reduction was determined to persist for about 6 h. In the experimental solutions, the ingredients dexpanthenol and zinc were able to reduce the expression of proinflammatory cytokines in the cell culture model, while the antiviral response was not altered significantly. Conclusion: We recommend the application of mouth wash solutions to COVID-19 patients, since our results indicate a reduction in infectivity and might govern the protection of health care professionals. Further improvement to the over the counter formulation can be made by utilizing zinc and dexpanthenol, as they which might be beneficial for the patients' health. [ABSTRACT FROM AUTHOR]

Background Postoperative sore throat (POST) is a complication that decreases patient satisfaction and increases postoperative complaints. The present study was conducted to investigate effects of gargling with dexamethasone, intravenous dexamethasone injection and the combination of the two on the incidence and severity of POST. Methods Study participants were 96 patients who had undergone laparoscopic cholecystectomy, randomly allocated into three groups. Group G gargled with 0.05% dexamethasone solution and were infused intravenous 0.9% normal saline before general anesthesia; group I gargled with 0.9% normal saline and were infused intravenous 0.1 mg/kg dexamethasone; group GI gargled with 0.05% dexamethasone solution and were infused intravenous 0.1 mg/kg dexamethasone. The incidence and severity of POST, hoarseness and cough were evaluated and recorded at 1, 6, and 24 h after the surgery. Results There were no significant differences in the total incidence of POST up to 24 postoperative hours among Group G, Group I and Group GI (P = 0.367, Group G incidence = 34.38%, [95% confidence interval, 95% CI = 17.92–50.83], Group I incidence = 18.75%, [95% CI = 5.23–32.27], Group GI incidence = 28.13%, [95% CI = 12.55–43.70]). The other outcomes were comparable among the groups. Conclusions In patients who had undergone laparoscopic cholecystectomy, gargling with 0.05% dexamethasone solution demonstrated the same POST prevention effect as intravenous injection of 0.1 mg/kg dexamethasone. The incidence and severity of POST were not significantly different between the combination of gargling with 0.05% dexamethasone solution and intravenous injection of 0.1 mg/kg dexamethasone and use of each of the preventive methods alone.

Background and Aims: All metal components of orthodontic appliances are somewhat corroded in the oral environment due to some changes in chemical, mechanical, thermal, microbiological and enzymatic factors which facilitates ion release. Ionic release can result in a discoloration of the surrounding soft tissue or allergic reactions in sensitive patients or even local pain in the area. In general, ions can cause toxic and biological side effects if their values reach the threshold, so the release of ions from the metal components of orthodontic appliances is important to us. The aim of this review article to determine the rate of orthodontic appliances ion release in different solutions. Materials and Methods: A review of the literature was carried out in Pubmed, Google Scholare and Web of science database using selected key words (Saliva/ Titanium/Normal Saline/ Ion release Orthodontic appliance/Mouth wash/ Nickel/ Chromium). These searches were limited to the articles published from 2005 to 2018. According to the inclusion and exclusion criteria, 25 articles were obtained. Results: Because of conflicts in the reported results, it was necessary to synchronize the measurement methods and also to use artificial saliva medium with normal pH as a control to achieve better systematic comparison. Conclusion: There was significant differences in the ion release between mouthwashes. In all studies, the effect of pH and acidity has been shown to increase the release of these ions. In addition, stainless steel (SS) instruments had the least biocompatibility among all types of alloys evaluated.

Context: Dentists across the globe are witnessing a completely unforeseen and uncertain professional situation during these times of COVID-19 pandemic. There is conflicting evidence regarding the effectiveness of routinely used mouthwashes and especially Chlorhexidine, to reduce the viral load in oral cavity and the aerosols during oral procedures. Aims: Comparative evaluation of the effectiveness of the current 'gold standard' chlorhexidine and povidone iodine as a control agent, through an in-vitro analysis. Settings and Design: In-vitro laboratory analysis. Methods and Material: All the experiments for analysis of antiviral efficacy of chlorhexidine digluconate (2%)and povidone iodine(1%), against SARS-CoV-2 virus were performed in the BSL3 facility at the Council of Scientific and Industrial Research-Institute of Microbial Technology, using the VeroE6 cell lines. The analysis of the virus inactivation was based on quantification of viral RNA (Cycle threshold (Ct) profile) present in the culture supernatant using Real-Time Quantitative Reverse Transcription PCR (qRT-PCR). Statistical Analysis Used: Descriptive analysis (Statistical package for social sciences (SPSS Inc., Chicago, IL, version 15.0 for Windows). Results: Chlorhexidine digluconate in 0.2% concentration inactivated more than 99.9% of SARS CoV 2 virus, in minimal contact time of 30 seconds, which was considered better efficacy than povidone-iodine utilized for 30 and 60 seconds. Subtle differences were observed in the activity of both the compounds in terms of percent inactivation of virus, though a greater relative change in Ct values was observed for chlorhexidine. Conclusions: Within the limitations of the present study, it can be concluded that Chlorhexidine digluconate in 0.2% concentration inactivated SARS CoV 2 in minimal contact time i.e 30 secs, however both compounds tested i.e Chlorhexidine and povidone-iodine were found to have antiviral activity against SARS CoV2 virus.

Introduction: Majority of the patient undergo endotracheal intubation for various time duration, when given general anaesthesia. Injury in airway mucosa or vocal cords due to endotracheal intubation can be a contributing factor. Ketamine without affecting local healing process has an antiproinflammatory effect as it limits exacerbation of systemic inflammation. Aim: To study the role of ketamine gargles as a pharmacological measure in order to attenuate POST, HOV and cough followed by endotracheal intubation during surgeries under general anaesthesia. Materials and Methods: A randomised controlled study was carried out for a duration of 22 months from the institutional ethical committee (Study Approval No. SVIEC/ON/MEDI/ BNPG18/D19046), on 50 patients of American Society of Anaesthesiologists (ASA) grade I and II. They were allocated into two groups of 25 patients. Group (K): ketamine 50 mg in 29 mL 0.9% normal saline and Group (C): 30 mL 0.9% normal saline. Patients were advised to gargle for 30 seconds just 5 minutes prior to induction of anaesthesia. Patients were intubated with appropriate size of the endotracheal tube and were extubated when fully awake and conscious. Pateints were shifted to postoperative ward and were kept in propped up position with oxygen. Pateints were assessed at 1,2,4,24 hours for incidence of POST, HOV and cough. Assessment was made as per the 4 point scale grading system. The statistical analysis was performed using unpaired t-test, p

Introduction: Majority of the patient undergo endotracheal intubation for various time duration, when given general anaesthesia. Injury in airway mucosa or vocal cords due to endotracheal intubation can be a contributing factor. Ketamine without affecting local healing process has an antiproinflammatory effect as it limits exacerbation of systemic inflammation. Aim: To study the role of ketamine gargles as a pharmacological measure in order to attenuate POST, HOV and cough followed by endotracheal intubation during surgeries under general anaesthesia. Materials and Methods: A randomised controlled study was carried out for a duration of 22 months from the institutional ethical committee (Study Approval No. SVIEC/ON/MEDI/ BNPG18/D19046), on 50 patients of American Society of Anaesthesiologists (ASA) grade I and II. They were allocated into two groups of 25 patients. Group (K): ketamine 50 mg in 29 mL 0.9% normal saline and Group (C): 30 mL 0.9% normal saline. Patients were advised to gargle for 30 seconds just 5 minutes prior to induction of anaesthesia. Patients were intubated with appropriate size of the endotracheal tube and were extubated when fully awake and conscious. Pateints were shifted to postoperative ward and were kept in propped up position with oxygen. Pateints were assessed at 1,2,4,24 hours for incidence of POST, HOV and cough. Assessment was made as per the 4 point scale grading system. The statistical analysis was performed using unpaired t-test, p<0.05 considered statistically significant. Results: In terms of POST grading in both K and C groups p-value was statistically significant (p<0.05) at 1 and at 2 hours postoperatively. In terms of HOV, in group K voice quality issues were reduced till 24 hours, (p<0.05). In terms of cough, in group K there was a significant reduction in complaints of cough till 4 hours postoperatively, (p<0.05). Conclusion: Ketamine gargles is effective in attenuating POST and cough till 2 hours and HOV till 4 hours postoperatively in patients following endotracheal intubation. [ABSTRACT FROM AUTHOR]

Background: Stomatitis is a frequent dose limiting toxicity of everolimus, an approved therapy for patients with metastatic breast cancer. No randomized trials of a prophylactic measure to prevent mucositis have been reported. Methods: We conducted a phase II, open-label trial in which patients with metastatic breast cancer starting everolimus were randomized to best supportive care (BSC) versus prophylactic use of an oral mucoadhesive, non-steroid containing mouth wash. The primary endpoint was rate of any grade stomatitis as reported by the treating physicians. Secondary endpoints were severity of stomatitis according to the Oral Mucositis Assessment Scale (OMAS) and rates of everolimus dose reduction or discontinuation due to mucositis. Results: Of 61 evaluable patients, 32 were randomized to and treated with oral mucoadhesive and 29 with BSC. Any grade stomatitis developed in 46.9% (15/32) of study arm and 65.5% (19/29) of BSC arm patients (p = 0.14). The difference between the two arms was significantly in favor of the mucoadhesive arm when mucositis was scored according to the OMAS with average score of 0.3 in study arm versus 0.5 in the control arm (p = 0.03). There were fewer dose adjustments or therapy discontinuations in the study arm compared with BSC (16% versus 31%, respectively) but the difference did not reach statistical significance. Conclusion: Here we provide early evidence from the first randomized trial supporting the use of oral prophylactic mucoadhesive for everolimus-associated stomatitis. A trial comparing prophylactic oral mucoadhesive to steroid mouth wash may be warranted. [ABSTRACT FROM AUTHOR]

Medicinal plants, plays a predominant role in curing and preventing diseases due to their antiviral and antimicrobial activity against human microorganism. Herbal Mouthwash are in high demand as compare to chemical mouthwash, because they act on mouth pathogen and microbes and reduce the pain instantly and are also has a no more side effects. The most commonly infectious diseases cause by a many pathogens and microbes are Dental carries and periodontal diseases at different stages of their life time. The aim of present work is to formulate and to evaluate its effectiveness against microbes present in oral cavity. The four herb Azadirecta indica (neem), Mentha longifolia (mint), Syzgium aromaticum (clove) and Ocimum sanctum (tulsi) were selected for mouth wash and Prepared formulation was further evaluated for physical properties like pH, color and stability. The present mouthwash possesses a good antibacterial property. This preparation is stable in different temperature condition Present mouthwash is a liquid preparation which normally contains antibacterial and antiseptic agents. These solutions can be used to reduce the microbial growth and it reduces infection in the oral cavity. [ABSTRACT FROM AUTHOR]

Background and Aims: All metal components of orthodontic appliances are somewhat corroded in the oral environment due to some changes in chemical, mechanical, thermal, microbiological and enzymatic factors which facilitates ion release. Ionic release can result in a discoloration of the surrounding soft tissue or allergic reactions in sensitive patients or even local pain in the area. In general, ions can cause toxic and biological side effects if their values reach the threshold, so the release of ions from the metal components of orthodontic appliances is important to us. The aim of this review article to determine the rate of orthodontic appliances ion release in different solutions. Materials and Methods: A review of the literature was carried out in Pubmed, Google Scholare and Web of science database using selected key words (Saliva/ Titanium/Normal Saline/ Ion release Orthodontic appliance/ Mouth wash/ Nickel/ Chromium). These searches were limited to the articles published from 2005 to 2018. According to the inclusion and exclusion criteria, 25 articles were obtained. Results: Because of conflicts in the reported results, it was necessary to synchronize the measurement methods and also to use artificial saliva medium with normal pH as a control to achieve better systematic comparison. Conclusions: There was significant differences in the ion release between mouthwashes. In all studies, the effect of pH and acidity has been shown to increase the release of these ions. In addition, stainless steel (SS) instruments had the least biocompatibility among all types of alloys evaluated. [ABSTRACT FROM AUTHOR]

Introduction: Poor oral hygiene results in dental caries and this has been associated with cardiovascular morbidities. Therefore achieving a good oral hygiene will significantly improve the quality of health. Materials and Methods: This was a crosssectional study; it was carried out between October and December 2016. Non-dental nurses in the hospital were consecutively recruited, and a pretested selfadministered questionnaire was administered. Results: There were 36 (37.1%) males, 61 (62.9%) females with male to female ratio of 1:1.7. Sixtysix percent of the respondents used toothbrush and paste for oral cleansing. However, majority of them changed their brush on 2–3 monthly basis; similarly, 56 (57.7%) of the respondents brushed at least twice in a day. Fortysix (47.4%) of the respondents used mouth wash while 51 (52.6%) did not; and among the nonusers, the majority (47.1%) believed mouth wash was ineffective. Thirtyeight (39.2%) of the respondents did brush for

Aims: This study was conducted to evaluate and compare the antimicrobial efficacy of green tea catechin as a mouth wash on colony count of Streptococcus mutans in children. Materials and Methods: A sample size of thirty children was selected out of screened 290 children by simple random sampling between the age group of 7 and 12 years. The study was conducted over a period of 2 weeks. After 24 h of oral prophylaxis, the baseline samples were collected and each group was subjected to mouth rinsing with green tea mouth wash for 2 weeks and further plaque and saliva samples were collected at 1- and 2-week intervals from baseline. Microbiological analysis of plaque and saliva samples was done by Dentocult SM strip kit (Orion Diagnostica, Finland), and the results were statistically analyzed and tabulated. Results: Statistically, there was highly significant reduction in S. mutans count in plaque as well as in saliva for after 1- and 2-week intervals from baseline. Conclusion: Hence, finally, our study showed that green tea catechin is effective as a mouth wash against S. mutans and having better action in plaque as compared to saliva. It can be used as an adjunct to commercially available mouthwashes.

Introduction: Oral hygiene aids help in maintaining a clean oral cavity to prevent dental problems, such as dental caries, gingivitis, and periodontitis. Plaque and calculus are the main causes of gingival disease, periodontal disease, and dental caries. There are various oral hygiene aids available to maintain a proper oral heath, but these oral hygiene aids need to be used in a right method to obtain the optimal results. A questionnaire was prepared to evaluate the knowledge of oral hygiene aids among students of professional colleges. Aim: This study aimed to assess oral hygiene aids related knowledge and practices among students of professional colleges. Materials and Methods: The study was conducted using a selfadministered, close-ended questionnaire with 15 questions to assess the oral hygiene aids knowledge and practices among 100 students of professional colleges. Results: The toothbrush with toothpaste is the most common oral hygiene aid used for cleaning teeth; it was observed that a greater number of students brushed their teeth twice a day. Conclusion: The study showed that the students had good knowledge about the basic oral health measures necessary to maintain proper oral health, but their attitude and practices toward oral health were relatively poor. [ABSTRACT FROM AUTHOR]

Objective: To test the effect of alcohol and non-alcohol containing mouthwashes on the force decay of clear and colored elastomeric chains. Method: An in-vitro prospective study to test the effect of exposure to alcohol on orthodontic elastomeric chains clear and colored. A sample of 72 specimens divided into three test groups, each group exposed to a single type mouth wash (deionized water (control); Listerine-zero; Listerine-original (26.9% alcohol)) for 60 seconds twice a day. Force measurements by a digital force tester were taken at days 0, 1, 7, 21. Finding: Increase in force decay over time was observed in all test groups, and is observed more with colored elastics. The test group exposed to Listerine original mouth wash had the highest mean force decays in all types of elastomeric chains, being more with colored chains. All of those findings were statistically significant. Conclusions: Mouth wash containing alcohol increase force decay of colored elastomeric chains with time, with color related differences in force decay of elastomeric chains. [ABSTRACT FROM AUTHOR]

Mycobacterial sputum culture is a key diagnostic and research tool. To compare mycobacterial culture outcomes of three sputum collection methods. We compared culture results within sets of three sputum samples collected from 18 HIV-infected adult tuberculosis patients at regular intervals up to 84 days after treatment initiation. The first sputum was collected at home and brought to the clinic, where a second and third sputum were consecutively collected under supervision following mouthwash with bottled water and chlorhexidine solution respectively. All sputa were processed for liquid culture in duplicate. Out of 556 cultures 430 (77.3%), 91 (16.4%) and 35 (6.3%) were positive, negative or contaminated, respectively. The odds of contamination were higher with home collection and with water rinse than with chlorhexidine rinse (OR: 12.5, p < 0.001 and OR: 6.7, p = 0.015). Chlorhexidine rinse increased the odds of a negative culture compared to water rinse (OR: 3.5, p = 0.002). The odds of a positive culture were greater with water rinse than with home collection (OR: 2.5, p = 0.005). Water rinse significantly reduced time to culture positivity. Compared to sputum collected at home, chlorhexidine rinse reduces culture contamination and water rinse increases the rate and viable mycobacterial load of positive cultures. [ABSTRACT FROM AUTHOR]

Context: Dentists across the globe are witnessing a completely unforeseen and uncertain professional situation during these times of COVID-19 pandemic. There is conflicting evidence regarding the effectiveness of routinely used mouthwashes and especially Chlorhexidine, to reduce the viral load in oral cavity and the aerosols during oral procedures. Aims: Comparative evaluation of the effectiveness of the current 'gold standard' chlorhexidine and povidone iodine as a control agent, through an in-vitro analysis. Settings and Design: In-vitro laboratory analysis. Methods and Material: All the experiments for analysis of antiviral efficacy of chlorhexidine digluconate (2%)and povidone iodine(1%), against SARS-CoV-2 virus were performed in the BSL3 facility at the Council of Scientific and Industrial Research-Institute of Microbial Technology, using the VeroE6 cell lines. The analysis of the virus inactivation was based on quantification of viral RNA (Cycle threshold (Ct) profile) present in the culture supernatant using Real-Time Quantitative Reverse Transcription PCR (qRT-PCR). Statistical Analysis Used: Descriptive analysis (Statistical package for social sciences (SPSS Inc., Chicago, IL, version 15.0 for Windows). Results: Chlorhexidine digluconate in 0.2% concentration inactivated more than 99.9% of SARS CoV 2 virus, in minimal contact time of 30 seconds, which was considered better efficacy than povidone-iodine utilized for 30 and 60 seconds. Subtle differences were observed in the activity of both the compounds in terms of percent inactivation of virus, though a greater relative change in Ct values was observed for chlorhexidine. Conclusions: Within the limitations of the present study, it can be concluded that Chlorhexidine digluconate in 0.2% concentration inactivated SARS CoV 2 in minimal contact time i.e 30 secs, however both compounds tested i.e Chlorhexidine and povidone-iodine were found to have antiviral activity against SARS CoV2 virus. [ABSTRACT FROM AUTHOR]

Aphthous stomatitis is one of the side effects of chemotherapy and radiotherapy in cancer treatment. Rebamipide (RB) mouthwash for stomatitis acts as a radical scavenger. However, RB is poorly soluble in water, which leads to aggregation and precipitation of the dispersoid. The particle size of the drug needs to be less than 100 nm for the particles to reach the mucus layer in the oral cavity. In this study, we attempted to prepare nanoparticles of RB by cogrinding with polyvinylpyrrolidone (PVP) or hydroxypropyl cellulose (HPC) and sodium dodecyl sulfate (SDS) using a mixer ball mill, and evaluated the physicochemical properties of RB nanoparticles, the stability of dispersion in water, and permeation of the mucus layer in vitro. By cogrinding, the particle size decreased to around 110 nm, and powder X-ray diffraction (PXRD) of the particles showed totally broad halo patterns, which suggested a decreased crystalline region. Furthermore, the solubility of RB nanoparticles increased by approximately fourfold compared with RB crystals, and the water dispersibility and permeation of the mucus layer were improved. The results suggest that in a ternary ground mixture of RB, PVP or HPC, and SDS, the RB nanoparticles obtained can be applied as a formulation for stomatitis.

Multiple investigations have confirmed carbohydrate mouth rinse (CMR) enhances high intensity endurance performance lasting under 1 hour, but the effects of CMR on high intensity intermittent exercise has received less attention. This study examined the effect of CMR on high intensity multiple sprint performances in a protocol designed to emulate a cyclocross or mountain biking event. Seven trained men (28.2 ± 6.8 years, 185 ± 9 cm, 85.3 ± 14.8 kg, VO2peak 51.4 ± 7.3 ml/kg*min-1) completed two, 48 min high intensity intermittent cycling protocols that consisted of 6 bouts of 5 min cycling at 50% VO2 peak followed by sets of three, 10-s Wingate sprints with 50 s of recovery between sprints. Prior to each set of Wingate sprints, either a 6.4% carbohydrate solution (CMR) or placebo (PLA) were rinsed for 10 s using a counterbalanced crossover design. There was a significant main effect (CMR 10.51 ± 0.82, PLA 10.33 ± 0.87 W/kg; p < 0.05 ES=0.21) for mean power, but post hoc tests only revealed statistically significant performance improvement with CMR during the 6th bout (CMR 10.5 ± 0.75, PLA 10.22 ± 0.92 W/kg; p = 0.01 ES=0.33). No treatment effect was exhibited for peak power, fatigue index, ratings of perceived exertion, or blood glucose. Most team sport situations provide multiple opportunities for access to beverages, but gastrointestinal distress associated with fluid intake may reduce desire for significant beverage consumption. Under such circumstances, a small but practical ergogenic advantage may be exhibited if the fluid rinsed in the mouth contains carbohydrates. [ABSTRACT FROM AUTHOR]

This study examined the effect of carbohydrate mouth rinsing on endurance running performance in women. Fifteen female recreational endurance runners, who used no oral contraceptives, ran two races of 1-h duration on an indoor track (216-m length) at 18:00 h after an 8-h fast with a 7-days interval between races, corresponding to the 3rd-10th day of each premenopausal runner’s menstrual cycle, or any day for the postmenopausal runners. In a double-blind random order, participants rinsed their mouth with 25 ml of either a 6.4% carbohydrate (RCHO) or a placebo solution (RP). No fluid was ingested during exercise. Serum 17β-Εstradiol (P = 0.59) and Progesterone (P = 0.35) did not differ between treatments. There was no difference in 1-hour running performance (RCHO: 10,621.88 ± 205.98 m vs. RP: 10,454.00 ± 206.64 m;t = 1.784,P = 0.096). Furthermore, the mean percentage effect (±99%CI) of RCHO relative to RP, 1.67% (−1.1% to 4.4%), and Cohen’s effect size (d = 0.21) support a trivial outcome of RCHO for total distance covered. In conclusion, carbohydrate mouth rinsing did not improve 60-min track running performance in female recreational runners competing in a low ovarian hormone condition, after an 8-h fast and when no fluid was ingested during exercise. [ABSTRACT FROM PUBLISHER]

Aim: Carbohydrate (CHO) mouth rinsing in the oral cavity has been shown to increase especially endurance exercise performance. Mechanisms responsible for this ergogenic effect may be related to receptors in oral cavity that detect CHO, in turn, increase neural drive to the motor unite. The aim of this study was to examine the effects of CHO mouth rinsing on intermittent sprint performance in soccer players. Material and Method: With randomised, double-blind, crossover, counterbalanced research design, fifteen amateur male soccer players (Mean±SD age:20.00±2.44 years, height:177.66±4.80 cm, body mass:75.02±6.42 kg) completed 3 sessions consisting of 12x4 seconds intermittent sprint tests with administering 10-second mouth rinse protocols before each sprint; a-) %6.4 carbohydrate solution (CHO) b-) water as a placebo (PLA) and 3-) no rinse as a control (CON). At rest, immediately after test and in active and passive recevory periods, blood glucose (BG), blood lactate (BL), heart rate (HR) and rating of perceived exertion (RPE) were assessed. Results: Compared with the CON condition, CHO and PLA increased significantly peak and mean power output (P<0.05), but there was no difference between CHO and PLA condition. BL and BG values were not statistically different between condition (P>0.05) but HR were significantly different in CON than CHO and PLA. Morover, RPE was significantly different in CON than PLA but not than CHO. Conclusion: CHO mouth rinsing does not improve peak and mean power when compared to PLA, but as a nocebo effect, CHO and PLA improve peak and mean power output with regard to CON. [ABSTRACT FROM AUTHOR]

Aims: to prepare Indomethacin mouth wash and study some of its properties (IR, pH, Density, Viscosity, Surface tension). Also, the effect on gingival index score were evaluated. Indomethacin mouth wash was prepared in a concentration of (0.05%) distil water from pure Indomethacin powder. Methods: The study was carried out on 40 subjects aged (20-30) years old. They were divided into four groups ten for each, three groups complaining of gingivitis. The gingival index score for all were measured before and after treatment, treatment involved mechanical treatment by scaling and polishing at dental clinic and drug treatment in which the first group received Indomethacin mouth wash, second group received Chlorhexidine mouth wash and third group received distal water as a mouth wash three times daily for three days, while the fourth group consisted of 10 volunteer subjects without gingivitis. Data were analyzed using paired t-test, ANOVA test and Duncan's Multiple analysis range test. Results: The results showed that the gingival index score levels were decreased significantly in all treatment groups between pre and post treatment at the same group. Conclusions: Indomethacin mouth wash have anti inflammatory effect that can decrease gingival index level.