1. Novel imprinted transcripts from the Dlk1-Gtl2 intergenic region, Mico1 and Mico1os, show circadian oscillations
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Labialle, S., Croteau, S., Bélanger, V., Mcmurray, E. N., Ruan, X., Moussette, S., Jonnaert, M., Schmidt, J. V., Nicolas Cermakian, Naumova, A. K., Laboratoire de biologie moléculaire eucaryote (LBME), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Biological Sciences [Chicago], University of Illinois [Chicago] (UIC), University of Illinois System-University of Illinois System, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I
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Cancer Research ,RNA, Untranslated ,[SDV]Life Sciences [q-bio] ,Molecular Sequence Data ,Biology ,Conserved sequence ,Genomic Imprinting ,Mice ,Intergenic region ,Transcription (biology) ,Animals ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,RNA, Messenger ,Imprinting (psychology) ,Molecular Biology ,Conserved Sequence ,Chromosome 12 ,Mammals ,Genetics ,Base Sequence ,Gene Expression Profiling ,Calcium-Binding Proteins ,Brain ,Gene Expression Regulation, Developmental ,Proteins ,Embryo, Mammalian ,Circadian Rhythm ,Gene expression profiling ,DLK1 ,Intercellular Signaling Peptides and Proteins ,DNA, Intergenic ,RNA, Long Noncoding ,Genomic imprinting - Abstract
International audience; Most of the known imprinted genes are assembled into clusters that share common imprinting control regions (ICRs). Non-coding transcripts are often associated with ICRs and implicated in imprinting regulation. We undertook a systematic search for transcripts originating from the Dlk1-Gtl2 intergenic region that contains the ICR for the chromosome 12 imprinted cluster and identified two overlapping transcripts expressed from opposite strands exclusively from the maternal chromosome. These novel imprinted transcripts most likely represent non-coding RNAs and are located telomeric to the IG DMR, extending the proximal boundary of the region of maternal-specific transcription. Their expression is tissue-specific and shows diurnal and circadian oscillations.Therefore, we named these novel transcripts maternal intergenic circadian oscillating 1 (Mico1) and Mico1, opposite strand (Mico1os).