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Novel imprinted transcripts from the Dlk1-Gtl2 intergenic region, Mico1 and Mico1os, show circadian oscillations
- Source :
- Scopus-Elsevier, Epigenetics, Epigenetics, Taylor & Francis, 2008, pp.322-9
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Abstract
- International audience; Most of the known imprinted genes are assembled into clusters that share common imprinting control regions (ICRs). Non-coding transcripts are often associated with ICRs and implicated in imprinting regulation. We undertook a systematic search for transcripts originating from the Dlk1-Gtl2 intergenic region that contains the ICR for the chromosome 12 imprinted cluster and identified two overlapping transcripts expressed from opposite strands exclusively from the maternal chromosome. These novel imprinted transcripts most likely represent non-coding RNAs and are located telomeric to the IG DMR, extending the proximal boundary of the region of maternal-specific transcription. Their expression is tissue-specific and shows diurnal and circadian oscillations.Therefore, we named these novel transcripts maternal intergenic circadian oscillating 1 (Mico1) and Mico1, opposite strand (Mico1os).
- Subjects :
- Cancer Research
RNA, Untranslated
[SDV]Life Sciences [q-bio]
Molecular Sequence Data
Biology
Conserved sequence
Genomic Imprinting
Mice
Intergenic region
Transcription (biology)
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
RNA, Messenger
Imprinting (psychology)
Molecular Biology
Conserved Sequence
Chromosome 12
Mammals
Genetics
Base Sequence
Gene Expression Profiling
Calcium-Binding Proteins
Brain
Gene Expression Regulation, Developmental
Proteins
Embryo, Mammalian
Circadian Rhythm
Gene expression profiling
DLK1
Intercellular Signaling Peptides and Proteins
DNA, Intergenic
RNA, Long Noncoding
Genomic imprinting
Subjects
Details
- ISSN :
- 15592294 and 15592308
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Epigenetics, Epigenetics, Taylor & Francis, 2008, pp.322-9
- Accession number :
- edsair.doi.dedup.....bccd1d0d1a99953f671490ecf2712bdb