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3. Comparison of survivals between sublobar resection and lobar resection for patients with clinical stage I non‐small cell lung cancer and interstitial lung disease: a propensity score matching analysis.

Author

Matsushima, Ryohei, Fujino, Kosuke, Motooka, Yamato, Yamada, Hiroyuki, Shirakami, Chika, Shinchi, Yusuke, Osumi, Hironobu, Yamada, Tatsuya, Yoshimoto, Kentaro, Ikeda, Koei, Kubota, Ichiro, and Suzuki, Makoto

Subjects
CANCER relapse, T-test (Statistics), THORACIC surgery, FISHER exact test, INTERSTITIAL lung diseases, TREATMENT effectiveness, RETROSPECTIVE studies, CHI-squared test, MANN Whitney U Test, MULTIVARIATE analysis, DESCRIPTIVE statistics, SURGICAL complications, KAPLAN-Meier estimator, LOG-rank test, MEDICAL records, ACQUISITION of data, LUNG tumors, STATISTICS, LUNG cancer, COMPARATIVE studies, DATA analysis software, OVERALL survival, PROPORTIONAL hazards models
Abstract

Background: Patients with early‐stage lung cancer and interstitial lung disease have a poorer prognosis than those without interstitial lung disease. This study aimed to compare the long‐term outcomes of lobar and sublobar resections in these patients. Methods: We retrospectively analyzed 138 consecutive patients with clinical stage I non‐small cell lung cancer and interstitial lung disease who underwent surgical treatment at two institutions between January 2010 and December 2020. Propensity score matching analysis was performed to adjust for baseline characteristics. Results: Thirty‐six patients underwent sublobar resection and 102 underwent lobar resection. The median follow‐up was 45.7 months. In all patients, 5‐year overall survival (OS) rates were 33.2% and 73.2%, and 5‐year recurrence‐free survival (RFS) rates were 24.2% and 60.1% in the sublobar and lobar resection groups, respectively (p < 0.01, <0.01). Death due to lung cancer and locoregional recurrence were significantly more frequent in the sublobar resection group than in the lobar resection group (p = 0.034, <0.01, respectively). On propensity score matching analysis, the 5‐year OS rates of the 19 matched pairs were 46.3% and 73.2%, and the RFS rates were 31.6% and 67.6% in the sublobar and lobar resection groups, respectively (p = 0.036, <0.01). The Cox proportional hazards model demonstrated a significant association between lobar resection and improved survival (p = 0.047). Conclusion: The patients in the lobar resection group had better survival rates than those in the sublobar resection group. In terms of long‐term prognosis, deliberately limited surgery may not be necessary for patients who tolerate lobectomy. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Imaging Microbubbles With Contrast-Enhanced Endobronchial Ultrasound

Author

McGrath, Sean, primary, Shen, Yu-Jack, additional, Aragaki, Masato, additional, Motooka, Yamato, additional, Koga, Takamasa, additional, Gregor, Alexander, additional, Bernards, Nicholas, additional, Cherin, Emmanuel, additional, Demore, Christine E.M., additional, Yasufuku, Kazuhiro, additional, and Matsuura, Naomi, additional

Published
2024
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15. Three-dimensional reconstructed CT images of an ex-vivo right lower human lung following marking at the point of maximum thin convex probe endobronchial ultrasound insertion.

Author

Ishiwata, Tsukasa, additional, Inage, Terunaga, additional, Gregor, Alexander, additional, Motooka, Yamato, additional, Chan, Harley H. L., additional, Bernards, Nicholas, additional, Aragaki, Masato, additional, Chen, Zhenchian, additional, Ujiie, Hideki, additional, Kinoshita, Tomonari, additional, Effat, Andrew, additional, and Yasufuku, Kazuhiro, additional

Published
2022
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16. Preclinical evaluation of thin convex probe endobronchial ultrasound-guided transbronchial needle aspiration for intrapulmonary lesions

Author

Ishiwata, Tsukasa, primary, Inage, Terunaga, additional, Gregor, Alexander, additional, Motooka, Yamato, additional, Chan, Harley H. L., additional, Bernards, Nicholas, additional, Aragaki, Masato, additional, Chen, Zhenchian, additional, Ujiie, Hideki, additional, Kinoshita, Tomonari, additional, Effat, Andrew, additional, and Yasufuku, Kazuhiro, additional

Published
2022
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17. Development of a minimally invasive pulmonary porcine embolism model via endobronchial ultrasound

Author

Inage, Terunaga, primary, Fujino, Kosuke, additional, Motooka, Yamato, additional, Ishiwata, Tsukasa, additional, Ujiie, Hideki, additional, Gregor, Alexander, additional, Bernards, Nicholas, additional, Chan, Harley H. L., additional, Chen, Zhenchian, additional, Aragaki, Masato, additional, Kinoshita, Tomonari, additional, Effat, Andrew, additional, Yoshino, Ichiro, additional, and Yasufuku, Kazuhiro, additional

Published
2022
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19. PRECLINICAL EVALUATION OF THIN CONVEX PROBE ENDOBRONCHIAL ULTRASOUND-GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION FOR INTRAPULMONARY LESIONS

Author

ISHIWATA, TSUKASA, primary, Inage, Terunaga, additional, Gregor, Alexander, additional, Motooka, Yamato, additional, Chan, Harley, additional, Aragaki, Masato, additional, Bernards, Nicholas, additional, Chen, Zhenchian, additional, Ujiie, Hideki, additional, Kinoshita, Tomonari, additional, Effat, Andrew, additional, Tatsumi, Koichiro, additional, and Yasufuku, Kazuhiro, additional

Published
2021
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20. Thrombolysis of Pulmonary Emboli via Endobronchial Ultrasound-Guided Transbronchial Needle Injection

Author

Inage, Terunaga, primary, Fujino, Kosuke, additional, Motooka, Yamato, additional, Ishiwata, Tsukasa, additional, Ujiie, Hideki, additional, Bernards, Nicholas, additional, Gregor, Alexander, additional, Chen, Zhenchian, additional, Aragaki, Masato, additional, Kinoshita, Tomonari, additional, Yoshino, Ichiro, additional, and Yasufuku, Kazuhiro, additional

Published
2021
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21. A preclinical research platform to evaluate photosensitizers for transbronchial localization and phototherapy of lung cancer using an orthotopic mouse model

Author

Ishiwata, Tsukasa, Seki, Takeshi, Gregor, Alexander, Aragaki, Masato, Motooka, Yamato, Kinoshita, Tomonari, Inage, Terunaga, Bernards, Nicholas, Ujiie, Hideki, Chen, Zhenchian, Effat, Andrew, Chen, Juan, Zheng, Gang, Tatsumi, Koichiro, Yasufuku, Kazuhiro, Ishiwata, Tsukasa, Seki, Takeshi, Gregor, Alexander, Aragaki, Masato, Motooka, Yamato, Kinoshita, Tomonari, Inage, Terunaga, Bernards, Nicholas, Ujiie, Hideki, Chen, Zhenchian, Effat, Andrew, Chen, Juan, Zheng, Gang, Tatsumi, Koichiro, and Yasufuku, Kazuhiro

Abstract

Background: Establishing the efficacy of novel photosensitizers (PSs) for phototherapy of lung cancer requires in vivo study prior to clinical evaluation. However, previously described animal models are not ideal for assessing transbronchial approaches with such PSs. Methods: An ultra-small parallel-type composite optical fiberscope (COF) with a 0.97 mm outer diameter tip. The integration of illumination and laser irradiation fibers inside the COF allows simultaneous white-light and fluorescence imaging, as well as real-time monitoring of tip position during laser phototherapy. An orthotopic lung cancer mouse model was created with three human lung cancer cell lines transbronchially inoculated into athymic nude mice. The COF was inserted transbronchially into a total of 15 mice for tumor observation. For in vivo fluorescence imaging, an organic nanoparticle, porphysome, was used as a PS. Laser excitation through the COF was performed at 50 mW using a 671 nm source. Results: The overall success rate for creating orthotopic lung tumors was 71%. Transbronchial white light images were successfully captured by COF. Access to the left main bronchus was successful in 87% of mice (13/15), the right main bronchus to the cranial lobe bronchus level in 100% (15/15), and to the right basal trifurcation of the middle lobe, caudal lobe and accessory lobe in 93% (14/15). For transbronchial tumor localization of orthotopic lung cancer tumors, PS-laden tumor with the strong signal was clearly contrasted from the normal bronchial wall. Conclusions: The ultra-small COF enabled reliable transbronchial access to orthotopic human lung cancer xenografts in vivo. This method could serve as a versatile preclinical research platform for PS evaluation in lung cancer, enabling transbronchial approaches in in vivo survival models inoculated with human lung cancer cells.

Published
2021

22. Pilot study using virtual 4-D tracking electromagnetic navigation bronchoscopy in the diagnosis of pulmonary nodules : a single center prospective study

Author

Ishiwata, Tsukasa, Ujiie, Hideki, Gregor, Alexander, Inage, Terunaga, Motooka, Yamato, Kinoshita, Tomonari, Aragaki, Masato, Chen, Zhenchian, Effat, Andrew, Bernards, Nicholas, Yasufuku, Kazuhiro, Ishiwata, Tsukasa, Ujiie, Hideki, Gregor, Alexander, Inage, Terunaga, Motooka, Yamato, Kinoshita, Tomonari, Aragaki, Masato, Chen, Zhenchian, Effat, Andrew, Bernards, Nicholas, and Yasufuku, Kazuhiro

Abstract

Background: Electromagnetic navigation bronchoscopy (ENB) is a navigation technology intended to improve the diagnostic yield of pulmonary nodules. However, nodule displacement due to respiratory motion may compromise the accuracy of the navigation guidance. The Veran SPiNDrive ENB system employs respiratory-gating (4D-tracking) to compensate for this motion. The aim of the present study was to evaluate the diagnostic performance and safety of the Veran SPiNDrive system for biopsy of pulmonary nodules. Methods: Adult patients with pulmonary nodules of ≥1 cm were enrolled at a single center. Both conventional bronchoscopy and 4D-tracking ENB were performed in one procedure session under general anesthesia, with the procedure order being randomly assigned. Radial probe endobronchial ultrasound and fluoroscopy were used in both groups. The diagnostic performance, safety, total procedure time, and total fluoroscopy time of the ENB phase were compared to the corresponding conventional bronchoscopy phase. Results: The study was terminated due to poor accrual; a total of eleven patients were enrolled. The mean size of pulmonary nodules was 2.1 cm. The sensitivity for malignancy was 67% (6/9) and 56% (5/9) with conventional bronchoscopy and with 4D-tracking ENB, respectively. Two cases developed minor bleeding after conventional bronchoscopy, while no complications were observed after 4D-tracking ENB. The mean procedure time was 16.1 and 21.7 min (P=0.090), and the mean duration time for fluoroscopy use was 77 and 44 sec (P=0.056) for the conventional bronchoscopy and the 4D-tracking ENB phases, respectively. Conclusions: The diagnostic performance of the Veran SPiNDrive 4D-tracking ENB did not exceed that of conventional bronchoscopy for pulmonary nodules. No complications were seen during 4D-tracking ENB. A study with a larger number of participants is required for further assessment.

Published
2021

23. Pilot study using virtual 4-D tracking electromagnetic navigation bronchoscopy in the diagnosis of pulmonary nodules: a single center prospective study

Author

Ishiwata, Tsukasa, primary, Ujiie, Hideki, additional, Gregor, Alexander, additional, Inage, Terunaga, additional, Motooka, Yamato, additional, Kinoshita, Tomonari, additional, Aragaki, Masato, additional, Chen, Zhenchian, additional, Effat, Andrew, additional, Bernards, Nicholas, additional, and Yasufuku, Kazuhiro, additional

Published
2021
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24. Photoacoustic imaging to localize indeterminate pulmonary nodules : A preclinical study

Author

Multhoff, Gabriele, Lee, Chang Young, Fujino, Kosuke, Motooka, Yamato, Gregor, Alexander, Bernards, Nicholas, Ujiie, Hideki, Kinoshita, Tomonari, Chung, Kyung Young, Han, Seung Hee, Yasufuku, Kazuhiro, Multhoff, Gabriele, Lee, Chang Young, Fujino, Kosuke, Motooka, Yamato, Gregor, Alexander, Bernards, Nicholas, Ujiie, Hideki, Kinoshita, Tomonari, Chung, Kyung Young, Han, Seung Hee, and Yasufuku, Kazuhiro

Abstract

Purpose Diagnosis and resection of indeterminate pulmonary nodules (IPNs) is a growing challenge with increased utilization of chest computed tomography. Photoacoustic (PA) -guided surgical resection with local injection of indocyanine green (ICG) may have utility for IPNs that are suspicious for lung cancer. This preclinical study explores the potential of PA imaging (PAI) to detect ICG-labeled tumors. Materials and methods ICG uptake by H460 lung cancer cells was evaluated in vitro. A phantom study was performed to analyze PA signal intensity according to ICG concentration and tissue thickness/ depth using chicken breast. PA signals were measured up to 48 hours after injection of ICG (mixed with 5% agar) into healthy subcutaneous tissue, subcutaneous H460 tumors and right healthy lung in nude mice. Results Intracellular ICG fluorescence was detected in H460 cells co-incubated with ICG in vitro. The concentration dependence of the PA signal was logarithmic, and PA signal decline was exponential with increasing tissue depth. The PA signal of 2 mg/mL ICG was still detectable at a depth of 22 mm in chicken breast. The PA signal from ICG mixed with agar was detectable 48 hours post injection into subcutaneous tissue and subcutaneous H460 tumors in nude mice. Similar features of PA signals from ICG-agar in mice lung were obtained. Conclusion The results from this preclinical study suggests that PAI of injected ICG-agar may be beneficial for identifying deeply located tumors. These features may be valuable for IPNs.

Published
2020

25. Intraluminal observation of the mouse bronchial tree using an ultra-small fiberscope [composite optical fiberscope (COF)]

Author

Ishiwata, Tsukasa, primary, Seki, Takeshi, additional, Gregor, Alexander, additional, Aragaki, Masato, additional, Motooka, Yamato, additional, Kinoshita, Tomonari, additional, Inage, Terunaga, additional, Bernards, Nicholas, additional, Ujiie, Hideki, additional, Chen, Zhenchian, additional, Effat, Andrew, additional, Chen, Juan, additional, Zheng, Gang, additional, Tatsumi, Koichiro, additional, and Yasufuku, Kazuhiro, additional

Published
2021
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26. Transbronchial fluorescence detection of a porphysome-laden tumor in an orthotopic lung cancer mouse model (mouse 1 in Figure 2). The tumor was localized in the cranial lobe. A part of the tumor at the entrance of the cranial lobe bronchus is easily seen by the composite optical fiberscope (COF), with a sharp contrast in fluorescence relative to the adjacent bronchial wall

Author

Ishiwata, Tsukasa, primary, Seki, Takeshi, additional, Gregor, Alexander, additional, Aragaki, Masato, additional, Motooka, Yamato, additional, Kinoshita, Tomonari, additional, Inage, Terunaga, additional, Bernards, Nicholas, additional, Ujiie, Hideki, additional, Chen, Zhenchian, additional, Effat, Andrew, additional, Chen, Juan, additional, Zheng, Gang, additional, Tatsumi, Koichiro, additional, and Yasufuku, Kazuhiro, additional

Published
2021
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27. A preclinical research platform to evaluate photosensitizers for transbronchial localization and phototherapy of lung cancer using an orthotopic mouse model

Author

Ishiwata, Tsukasa, primary, Seki, Takeshi, additional, Gregor, Alexander, additional, Aragaki, Masato, additional, Motooka, Yamato, additional, Kinoshita, Tomonari, additional, Inage, Terunaga, additional, Bernards, Nicholas, additional, Ujiie, Hideki, additional, Chen, Zhenchian, additional, Effat, Andrew, additional, Chen, Juan, additional, Zheng, Gang, additional, Tatsumi, Koichiro, additional, and Yasufuku, Kazuhiro, additional

Published
2021
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30. PRECLINICAL EVALUATION OF PROTOTYPE 21- AND 25-GAUGE SAMPLING NEEDLES USING A THIN CONVEX PROBE ENDOBRONCHIAL ULTRASOUND

Author

Inage, Terunaga, primary, ISHIWATA, TSUKASA, additional, Joerg, Schwock, additional, Motooka, Yamato, additional, Ujiie, Hideki, additional, Kinoshita, Tomonari, additional, Gregor, Alexander, additional, Bernards, Nicholas, additional, Chen, Zhenchian, additional, Effat, Andrew, additional, Yoshino, Ichiro, additional, and Yasufuku, Kazuhiro, additional

Published
2019
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31. Evaluation of Novel Imaging Devices for Nanoparticle-Mediated Fluorescence-Guided Lung Tumor Therapy

Author

Kinoshita, Tomonari, primary, Ujiie, Hideki, additional, Chen, Juan, additional, Ding, Lili, additional, Chan, Harley, additional, Gregor, Alexander, additional, Bernards, Nicholas, additional, McVeigh, Patrick Z., additional, Fujino, Kosuke, additional, Lee, Chang Young, additional, Motooka, Yamato, additional, Inage, Terunaga, additional, Valic, Michael S., additional, Effat, Andrew, additional, Weersink, Robert, additional, Wilson, Brian C., additional, Zheng, Gang, additional, Asamura, Hisao, additional, and Yasufuku, Kazuhiro, additional

Published
2019
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32. Significance of Tsukushi in lung cancer

Author

Yamada, Tatsuya, primary, Ohta, Kunimasa, additional, Motooka, Yamato, additional, Fujino, Kosuke, additional, Kudoh, Shinji, additional, Tenjin, Yuki, additional, Sato, Younosuke, additional, Matsuo, Akira, additional, Ikeda, Koei, additional, Suzuki, Makoto, additional, and Ito, Takaaki, additional

Published
2019
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37. Novel approach to pleurodesis with 50 % glucose for air leakage after lung resection or pneumothorax

Author

Fujino, Kosuke, primary, Motooka, Yamato, additional, Koga, Takamasa, additional, Osumi, Hironobu, additional, Matsubara, Eri, additional, Shibata, Hidekatsu, additional, Ikeda, Koei, additional, Shiraishi, Kenji, additional, Mori, Takeshi, additional, Hayashi, Koji, additional, Yoshimoto, Kentaro, additional, Wakimoto, Jyoeji, additional, Kubota, Ichiro, additional, and Suzuki, Makoto, additional

Published
2015
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40. [Chronic Progressive Pulmonary Aspergillosis after Surgery for Lung Cancer].

Author

Yamada T, Mori T, Nishi W, Motooka Y, Ikeda K, Shiraishi K, and Suzuki M

Subjects
Chronic Disease, Disease Progression, Humans, Lung Neoplasms diagnosis, Male, Middle Aged, Neoplasm Staging, Pneumonectomy, Tomography, X-Ray Computed, Lung Neoplasms surgery, Postoperative Complications, Pulmonary Aspergillosis diagnostic imaging
Abstract

Case 1:A 62-year-old man underwent right S9+10 segmentectomy for non-small cell lung cancer. Three years later, pleural thickening appeared in the apex, and gradually developed cystic change. Case 2:A 64-year-old man underwent left upper lobectomy for non-small cell lung cancer. One year after surgery, chest computed tomography (CT) showed cysts in the apex of the lower lobe. The cysts expanded slowly with consolidation. Both cases were diagnosed as chronic progressive pulmonary aspergillosis. Although anti-fungal drugs were administered in both cases, case 1 died of the disease. Chronic progressive pulmonary aspergillosis is a rare late postoperative complication;when CT shows progressive cysts with consolidation in the apex area of the residual lung, frequent check-ups are needed.

Published
2016

41. [A case of imatinib-resistant gastrointestinal stromal tumor treated with low-dose sunitinib].

Author

Yoshida Y, Akahoshi S, Kiyota Y, Motooka Y, Kiyozumi Y, Yamaguchi R, and Inoue K

Subjects
Aged, 80 and over, Antineoplastic Agents administration & dosage, Benzamides, Gastrointestinal Stromal Tumors physiopathology, Gastrointestinal Stromal Tumors secondary, Humans, Imatinib Mesylate, Indoles administration & dosage, Intestinal Neoplasms pathology, Intestinal Neoplasms surgery, Male, Peritoneal Neoplasms drug therapy, Peritoneal Neoplasms secondary, Peritoneal Neoplasms surgery, Piperazines, Pyrimidines, Pyrroles administration & dosage, Recurrence, Salvage Therapy, Sunitinib, Antineoplastic Agents therapeutic use, Drug Resistance, Neoplasm, Gastrointestinal Stromal Tumors drug therapy, Indoles therapeutic use, Intestinal Neoplasms drug therapy, Intestine, Small surgery, Pyrroles therapeutic use
Abstract

The patient was an 82-year-old man who had undergone resection of a gastrointestinal stromal tumor(GIST)of the small intestine in January 2000, when he was 69 years old. As peritoneal recurrences were diagnosed in June 2002, we performed peritoneal tumorectomy twice, and the perirectal tumor was controlled with imatinib for over 7 years. Resistance to imatinib was diagnosed in March 2011, and treatment was switched to sunitinib. Administration of sunitinib was started at 50mg/day for 28 days followed by treatment withdrawal for 14 days; however, the dose needed to be reduced twice and then discontinued owing to the occurrence of side effects and pemphigoid. During discontinuation of sunitinib, the tumor increased in size and cancer pain appeared; therefore, sunitinib was re-administered at a very low-dose of 12.5mg every alternate day. Low dose sunitinib was effective; the perirectal tumor was reduced and cancer pain disappeared.

Published
2013

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