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Background and Objectives Water shortage and the need for its optimal use in arid and semi-arid regions, including Iran, has led water officials and farmers to use modern irrigation systems, such as drip irrigation with the aim of making optimal use of water resources. Drip irrigation has been welcomed in most parts of the world due to its high efficiency and the possibility of irrigation in different environmental conditions. The most important reason for the superiority of drip irrigation over other irrigation methods is the controllable amount of water for each plant. Drip irrigation is a method in which water is poured out of the net at low pressure through an orifice or device called an emitter and dripped into the bottom of the plant. This irrigation system, like other methods, requires accurate knowledge of the parameters affecting it to achieve the desired efficiency. One of the most important parameters for the irrigation system is the distribution of moisture in the soil and in fact the shape of the moist bulb. Therefore, knowledge of how to distribute water in the soil is essential for the proper design and management of subsurface drip irrigation systems. Since testing is very difficult and time consuming to detect the shape of moisture distribution in the soil, the use of numerical and analytical simulation can be an effective and efficient way to design these systems. Methodology In order to determine the progress of the moisture front in drip irrigation, first the soil texture type and physical properties of the soil were determined. It should be noted that the emitter flow rate was measured and adjusted in volume at the beginning of the test to minimize the difference between the emitter flows along the three side tubes. Evaluation experiments were performed with three outflows of 2, 4 and 6 liters per hour. With the start of the system, the progress of the moisture front at different times was measured by digging a trench using a scale. Numerical simulation of moisture front progress was performed using HYDRUS model based on Richard equation and analytical simulation was performed using Moment Analysis. HYDRUS software was used to numerically simulate the progress of the moisture front. The simulation range was considered to be 100 cm by 100 cm on the two-dimensional plane. In these simulations, 3956 nodes are used to represent the entire simulation range and also, relevant equations were used to calculate the two-dimensional spatial Moment of the wetting pattern . Findings The simulations show that the initial volumetric moisture content is 0.11 and the saturation volumetric moisture content is 0.380 and the water dispersion rate increases over time on the x and z axes. With increasing flow, the maximum dispersion is in the x-axis, which occurs in flow of 6 liters per hour. The result for flow of 6 liters per hour based on the data used is slightly higher than the desired value. The reason why the value of M00 in the flow rate of 6 liters per hour is higher than expected, is that in the simulation flow rate of 6 liters per hour change in the size of the inlet diameter and the amount of flux changes the amount of water entering the soil and moistens a large volume of soil. Due to the different amount of moisture applied to the area at different times, the value of 𝑧𝑐, 𝜎𝑥 2, 𝜎𝑧 2 is different and has caused a change in the size of the oval in different flows. The increase in the size of the ovals indicates the high dispersion of water in that area. The results showed that the Moment analysis was able to express the position of the center of mass of water distributed in the soil with correlation coefficient of 0.986 in linear mode and 0.982 in logarithmic mode. By comparing the values of diameter and depth obtained from the HYDRUS and the drawn ovals, it can be concluded that both methods provide close results. The accuracy of the Moment analysis method in simulating different types of moisture patterns resulting from drip irrigation under different flows with the use of different volumes of water is similar to the HYDRUS model and therefore it is possible to use this feature to predict the pattern of moisture from a certain flow using a specific volume of water . Conclusion In this study, the accuracy of Moment analysis in simulating various moisture patterns resulting from drip irrigation under different flows with the use of different volumes of water was investigated and the possibility of using this feature to predict the pattern of moisture from a given flow using a specific volume of water checked. In order to investigate the Moment of the amount of water distributed in the soil by subsurface drip irrigation, simulation was performed by two-dimensional HYDRUS software for three discharges of 2, 4 and 6 liters per hour with an inlet water volume of 12 liters. Then, using the results of simulation of moisture distribution range by a programming language including MATLAB software, and by calculating the Moments, it was determined that the Moments are able to express the position of the center of mass of water distributed in the soil and how it is distributed relative to x and z axes. The increase in the size of the ovals indicates that more water is distributed in that area. Comparing the diameters and depths of the moisture front between the simulated HYDRUS model and the Moment analysis model, it was found that the Moment analysis is an efficient way to study the distribution of water moisture by drip irrigation and this method can be used as an alternative input to estimate parameters. [ABSTRACT FROM AUTHOR]

Mesenchymal hamartoma and hepatoblastoma are common causes of hepatic masses in pediatric population; they have similar radiologic and pathologic features. Herein, we present a case of mesenchymal hamartoma that was preoperatively diagnosed as hepatoblastoma. The mass was completely resected instead of being treated with preoperative chemotherapy. Postoperative pathological evaluation revealed mesenchymal hamartoma with free margins; the patient incidentally received the standard treatment. If we would have measured serum AFP in our patient, we could make the correct diagnosis preoperatively, because AFP increases largely in hepatoblastoma. When suspicious exists, serum AFP is a good guide in differentiating hepatoblastoma from mesenchymal hamartoma. [ABSTRACT FROM AUTHOR]

Metal halide perovskites and perovskite-related organic metal halide hybrids (OMHHs) have recently emerged as a new class of luminescent materials for light emitting diodes (LEDs), owing to their unique and remarkable properties, including near-unity photoluminescence quantum efficiencies, highly tunable emission colors, and low temperature solution processing. While substantial progress has been made in developing monochromatic LEDs with electroluminescence across blue, green, red, and near-infrared regions, achieving highly efficient and stable white electroluminescence from a single LED remains a challenging and under-explored area. Here, a facile approach to generating white electroluminescence is reported by combining narrow sky-blue emission from metal halide perovskites and broadband orange/red emission from zero-dimensional (0D) OMHHs. For the proof of concept, utilizing TPPcarz + passivated two-dimensional (2D) CsPbBr 3 nanoplatelets (NPLs) as sky blue emitter and 0D TPPcarzSbBr 4 as orange/red emitter (TPPcarz + = triphenyl (9-phenyl-9H-carbazol-3-yl) phosphonium), white LEDs (WLEDs) with a solution processed bilayer structure have been fabricated to exhibit a peak external quantum efficiency (EQE) of 4.8% and luminance of 1507 cd m -2 at the Commission Internationale de L'Eclairage (CIE) coordinate of (0.32, 0.35). This work opens a new pathway for creating highly efficient and stable WLEDs using metal halide perovskites and related materials., (© 2024 Wiley‐VCH GmbH.)

Introduction: Exposure to electric and magnetic fields (EMF) is a phenomenon that has always been present. In the last two decades, there have been numerous worries about the possible effects of extremely low-frequency (ELF) fields on human health. Consequently, this study aims to measure and evaluate the effect of ELF fields on blood parameters and liver enzymes of personnel working in high-voltage power stations in the petrochemical industry., Methods: This cross-sectional, descriptive-analytical study was done in a petrochemical industry in southern Iran in 2021. Two groups of 50 people were selected to attain the research goals and classify jobs with the risk of exposure to extremely low-frequency electromagnetic fields (ELF-EMF) and the time spent on work. One group was exposed to ELF-EMF, and the other was regarded as the control group. Electromagnetic fields were measured using the HI-3604 device and the standard method of IEEE 1994-644. The workers' demographic data, blood parameters, and liver enzymes were also obtained from the workers' medical records. The course of changes in each of the blood parameters and liver enzymes and demographic variables in the control and case groups were then examined. In the last stage, the effect of the electric field and magnetic field on the blood parameters and liver enzymes of the two control and subject groups was conducted using the multiple regression model., Results: The measured points in all stations are 200, and the minimum and maximum values of the magnetic field was 0.8 and 2019 mG, respectively. The minimum and maximum values of the electric field intensity was 0.003 and 215 V/m, respectively. The average results of the demographic variables and blood and liver indices in the control and case groups from 2018 to 2020 revealed that the average variables were not significantly different in the case and control groups (p-value>0.05). Moreover, workers' exposure to ELF-EMF was below the permissible limit., Conclusion: Based on the results of the present study, ELF-EMF does not have any significant effects on demographic factors, blood parameters, and liver enzymes., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 Published by Elsevier Ltd.)

Background: Pink-collar workers are a group of workers in the service industries. Teachers are classified as a group of pink-collar workers, who are under a high level of stress. This study aimed to investigate the effect of physical exposures and job stress on mental health and sleep quality of technical and vocational teachers., Materials and Methods: This cross-sectional study was conducted on 622 teachers. The Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) were employed to evaluate sleep status; the Osipow Questionnaire was used to assess job stress; the musculoskeletal intervention center - Norrtalje questionnaire (MUSIC) was used to measure physical exposures; and the 12-Item General Health Questionnaire was used to assess mental health., Results: The mean scores of general health, job stress, and work hardness were 10.97 ± 6.29, 153.40 ± 22.63, and 15.61 ± 2.77, respectively; the mean score of ESS and PSQI were 6.22 ± 3.61 and 5.44 ± 2.97, respectively. The mental health status of the participants was significantly worse with more exposure to various types of job stressors and physical exposures. There was a significant relationship between sleep quality and general health score., Conclusion: The mental health status was considerably better in women, smokers, and people who exercised, have less work experience, do not do shift work, work fewer hours per week, and have good sleep quality. Physical exposures and various occupational stressors can reduce mental health. There was a significant relationship between job stress and decreased sleep quality but sleep quality was not significantly associated with age, BMI, work experience, and working hours per week., Competing Interests: There are no conflicts of interest., (Copyright: © 2022 Indian Journal of Occupational and Environmental Medicine.)

Introduction: Bifid rib as pathoanatomical findings on chest X-ray is a skeletal disorder. It is usually unilateral and commonly found in males. Bifid ribs commonly happen in absence of structural defects of the vertebrae., Presentation of Case: The case of this report is a 65-year-old with severe infection of Covid 19. He was admitted to the ICU. Imaging findings indicate existence of a bifid rib with vertebral fusion., Discussion: Bifurcated ribs usually have been described without vertebral defects. In our case, there is a bifurcated rib with fused vertebrae. These defects are also defined in the criteria of Gorlin syndrome., Conclusion: Unlike other rib abnormalities, the bifid rib occurs mainly in the absence of a vertebral defect, but this study reports a bifid rib with vertebral defects., (Copyright © 2021. Published by Elsevier Ltd.)

In recent years, PCR-based methods as a rapid and high accurate technique in the industry and medical fields have been expanded rapidly. Where we are faced with the COVID-19 pandemic, the necessity of a rapid diagnosis has felt more than ever. In the current interdisciplinary study, we have proposed, developed, and characterized a state-of-the-art liquid cooling design to accelerate the PCR procedure. A numerical simulation approach is utilized to evaluate 15 different cross-sections of the microchannel heat sink and select the best shape to achieve this goal. Also, crucial heat sink parameters are characterized, e.g., heat transfer coefficient, pressure drop, performance evaluation criteria, and fluid flow. The achieved result showed that the circular cross-section is the most efficient shape for the microchannel heat sink, which has a maximum heat transfer enhancement of 25% compared to the square shape at the Reynolds number of 1150. In the next phase of the study, the circular cross-section microchannel is located below the PCR device to evaluate the cooling rate of the PCR. Also, the results demonstrate that it takes 16.5 s to cool saliva samples in the PCR well, which saves up to 157.5 s for the whole amplification procedure compared to the conventional air fans. Another advantage of using the microchannel heat sink is that it takes up a little space compared to other common cooling methods., (© 2021. The Author(s).)

Objectives: To compare the outcomes of early excision and grafting between pediatric and adult patients with deep burns of less than 40% total body surface area burns (TBSA)., Methods: This is a prospective comparative study. Overall, 106 patients admitted to Ghotbodin Burn Center in Shiraz, Iran from September 2012 to September 2013, were included in the study. All patients had less than 40% TBSA burn and had excision and grafting under 14 days from their injury. Patients were divided into two age groups of younger than 14 (n=49) and older than 14 (14-65) years old (n=57). During a 6-month follow-up period, the two groups were compared regarding mean percentage of graft take, total scar score, duration of hospital stay and itching score., Results: During follow-up, the two groups did not show a significant difference in graft take, total scar score and itching score ( p =0.461, p =0.363 and p =0.637, respectively). Clinically, the pediatric group showed less hospital stay (12.25±9.1 vs. 16±12.9), however this was not statistically significant ( p =0.091)., Conclusion: Adults and elderly patients (14-65 years old) compared to pediatric patients (less than 14 years old) with less than 40% TBSA burns, can expect similar results regarding scar score, graft take, itch score and hospital stay, after excision and grafting performed less than two weeks from their initial injury., Competing Interests: None of the authors have any commercial and financial conflicts of interest to be declared regarding the manuscript.

Background: Radiotherapy is one of the most important factors which results in negative effects on wound healing and increases anastomosis leakage. Diverting loop ileostomy has been usually performed after colorectal anastomosis in cases of colorectal cancer with a history of neoadjuvant radiotherapy to decrease the chance of leakage. Considering the side effects of diverting loop ileostomy, the objective of the present study is to investigate the effect of human amniotic membrane (HAM) on colorectal anastomosis leakage after neo-adjuvant radiotherapy., Methods: In this experimental animal study, 20 crossbreed rabbits were randomly divided into two groups (case group: 13 rabbits, control group: 7 rabbits) after receiving an equal dose of external beam radiation. Four weeks after irradiation, resection of 4 cm of colorectal segment and end-to-end single layer anastomosis were conducted. In the case group, a 2×2 cm wrap of HAM applied around the site of anastomosis. Eight weeks later, all the survived rabbits were sacrificed. A segment of anastomotic sites was resected in all expired and survived rabbits and sent for pathological evaluation. Mann-Whitney U Test (SPSS for Windows, Ver. 16, Chicago, IL) was applied to analyze healing scores between the two groups., Results: Due to anastomosis dehiscence, 5 rabbits expired in the control group, but all the 13 rabbits (case group) survived after 8 weeks and showed no leakage. In addition, pathological evaluation revealed significant epithelialization and neovascularization in the case group. Statistically, healing score was higher in the case group rather than the control group (P<0.001)., Conclusion: To prevent post irradiation colorectal anastomosis leakage, the use of HAM might play a significant role and a feasible technical approach.

Background: Nonlinear analysis of heart rate variability (HRV) has been recently used as a predictor of prognosis in trauma patients., Objectives: We applied nonlinear analysis of HRV in patients with blunt trauma and intraperitoneal bleeding to assess our ability to predict the outcome of conservative management., Patients and Methods: An analysis of electrocardiography (ECG) from 120 patients with blunt trauma was conducted at the onset of admission to the emergency department. ECGs of 65 patients were excluded due to inadequacy of noise-free length. Of the remaining 55 patients, 47 survived (S group) and eight patients died in the hospital (Non-S group). Nineteen patients were found to have intra-abdominal bleeding, eight of which ultimately underwent laparotomy to control bleeding (Op group) and 11 underwent successful non-operative management (non-Op). Demographic data including vital signs, glasgow coma scale (GCS), arterial blood gas and injury severity scores (ISS) were recorded. Heart rate complexity (HRC) methods, including entropy, were used to analyze the ECG., Results: There were no differences in age, gender, heart rate (HR) and blood pressure between the S and Non-S groups. However, approximate entropy, used as a method of HRC measurement, and GCS were significantly higher in S group, compared to the Non-S group. The base deficit and ISS were significantly higher in the Non-S group. Regarding age, sex, ISS, base deficit, vital signs and GCS, no difference was found between Op and Non-Op groups. Approximate entropy was significantly lower in the Op group, compared to the Non-Op group., Conclusions: The loss of HRC at the onset of admission may predict mortality in patients with blunt trauma. Lower entropy, in recently admitted patients with intra-abdominal bleeding, may indicate laparotomy when the vital signs are stable.

Unlabelled: The existence of a link between estrogen deprivation and osteoarthritis (OA) in postmenopausal women suggests that 17β-estradiol (17β-E2) may be a modulator of cartilage homeostasis. Here, we demonstrate that 17β-E2 stimulates, via its receptor human estrogen receptor α 66 (hERα66), type II collagen expression in differentiated and dedifferentiated (reflecting the OA phenotype) articular chondrocytes. Transactivation of type II collagen gene (COL2A1) by ligand-independent transactivation domain (AF-1) of hERα66 was mediated by "GC" binding sites of the -266/-63-bp promoter, through physical interactions between ERα, Sp1/Sp3, Sox9, and p300, as demonstrated in chromatin immunoprecipitation (ChIP) and Re-Chromatin Immuno-Precipitation (Re-ChIP) assays in primary and dedifferentiated cells. 17β-E2 and hERα66 increased the DNA-binding activities of Sp1/Sp3 and Sox-9 to both COL2A1 promoter and enhancer regions. Besides, Sp1, Sp3, and Sox-9 small interfering RNAs (siRNAs) prevented hERα66-induced transactivation of COL2A1, suggesting that these factors and their respective cis-regions are required for hERα66-mediated COL2A1 up-regulation. Our results highlight the genomic pathway by which 17β-E2 and hERα66 modulate Sp1/Sp3 heteromer binding activity and simultaneously participate in the recruitment of the essential factors Sox-9 and p300 involved respectively in the chondrocyte-differentiated status and COL2A1 transcriptional activation. These novel findings could therefore be attractive for tissue engineering of cartilage in OA, by the fact that 17β-E2 could promote chondrocyte redifferentiation., Key Messages: 17β-E2 up-regulates type II collagen gene expression in articular chondrocytes. An ERα66/Sp1/Sp3/Sox-9/p300 protein complex mediates this stimulatory effect. This heteromeric complex interacts and binds to Col2a1 promoter and enhancer in vivo. Our findings highlight a new regulatory mechanism for 17β-E2 action in chondrocytes. 17β-E2 might be an attractive candidate for cartilage engineering applications.

We previously reported that the cinnamylpiperazinyl group in the side chain of the chenodeoxycholic acid showed apoptosis-inducing activity on multiple myeloma cancer cell line KMS-11. In the present study, we synthesized and tested the pro-apoptotic potency of fifteen new piperazinyl bile carboxamide derived from cholic, ursodeoxycholic, chenodeoxycholic, deoxycholic and lithocholic acids on human colon adenocarcinoma cell lines DLD-1, HCT-116, and HT-29. Cell viability was first measured using XTT assay. The most of the synthetic bile carboxamide derivatives decreased significantly cell viability in a dose-dependent manner. HCT-116 and DLD-1 cell lines were more sensitive than HT-29 to tested compounds. 9c, 9d showed the best in vitro results in term of solubility and dose-response effect on the three colon adenocarcinoma cell lines. Additionally, flow cytometric and Western-blotting analysis showed that 9c induced pro-apoptosis in DLD-1 and HCT-116 whereas 9d did not. We conclude that the benzyl group improved anti-proliferative activity and that the α-hydroxyl group was found to be more beneficial at the 7-position in steroid skeleton., (Copyright © 2014. Published by Elsevier Masson SAS.)

Objective: To evaluate the outcomes of jejunal serosal patch and jejunal pedicled flap procedures for the repair of duodenal injuries., Methods: The experimental animal-model study was conducted at Shiraz University of Medical Sciences, Iran, in February 2013. Ten mixed-breed male dogs were selected and randomly divided into groups A and B. After general anaesthesia, a large duodenal defect was created in all animals. The defect was repaired with jejunal pedicled flap in group A and jejunal serosal patch in group B. Microscopic healing was scored according to epithelialisation, collagenisation, inflammation, ulcer and necrosis of samples. Kolmogorov-Smirnov and independent t-test were used to indicate normal distributions of data and statistical differences between the two groups respectively., Results: The weight of the animals ranged between 23 and 37 kg and the age range was 12-16 months. All dogs survived the procedures. Anastomotic leakage, intra-abdominal abscess or intestinal obstructions were not detected in gross examination. Healing score was significantly higher in the group A than group B (p < 0.011). However, in terms of surgical findings, no significant difference was detected between the groups (p > 0.05)., Conclusion: Applying jejunal pedicled flap for repairing large duodenal defects would lead to better histologic outcomes compared to jejunal serosal patch in dogs.

Segmental resection and end-to-end anastomosis is the treatment of choice for patients suffering from tracheal stenosis for whom conservative management is not planned. A complication of this procedure is tension-induced anastomotic failure. To prevent this complication, maintaining the neck in full flexion by means of a suture between the chin and upper chest is a traditional approach. We have designed a new brace (Shiraz brace) that securely supports the neck in this position and decreases the bothersome use of the suture alone.