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5. The identification, goals and principles of difficult-to-treat inflammatory arthritis: a consensus statement

Author

El Miedany, Yasser, Abu-Zaid, Mohammed Hassan, El Gaafary, Maha, Mansour, Mona, Elwy, Mohamed, Palmer, Deborah, Fathi, Nihal, Hassan, Waleed, Mortada, Mohamed, Eissa, Mervat, Tabra, Samar Abdelhamed, Galal, Salwa, Fouad, Nermeen, Ibrahim, Rehab Ali, Medhat, Basma, Adel, Yasmin, Ghaleb, Rasha, Saber, Sally, Gadallah, Naglaa, and Elwakil, Walaa

Published
2023
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6. Consensus evidence-based recommendations for transition of care for adolescents with juvenile idiopathic arthritis: meeting patients’, parents’, and rheumatologists’ perspectives

Author

Miedany, Yasser El, Abu-Zaid, Mohammed Hassan, Eissa, Mervat, Hassan, Waleed A., Mortada, Mohamed, Tabra, Samar abd Alhamed, Mohamed, Sally S., Maher, Sheren Esam, Gaafary, Maha El, Medhat, Basma M., Mosa, Doaa Mosad, Fouad, Nermeen Ahmed, Amer, Youmna Ahmed, Nasef, Samah Ismail, Shalaby, Radwa H., Adel, Yasmin, Elkhalek, Reham Abd, Mahgoub, Marwa Yahia, and Lotfy, Hala M.

Published
2023
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7. Egyptian recommendations for the management of systemic lupus erythematosus: a consensus, evidence-based, clinical practice guidelines for treat-to-target management

Author

El Miedany, Yasser, Elhadidi, Khaled, Mahmoud, Geilan Abdelmoneim, Abu-Zaid, Mohammed Hassan, Mahmoud, Atef Abdelazim, El Gaafary, Maha, Kamel, Nadia, Fathi, Nihal Ahmed, Nasser, Ahmed Abdel, Hassan, Waleed, Eissa, Mervat, Sarhan, Eman, Aboalfadl, Essam, Mansour, Ahmed Ezzat, Mortada, Mohamed, Fouad, Nermeen Ahmed, Elaraby, Ismail, Elnemr, Rehab, Medhat, Basma M., Mohamed, Sally S., Ibrahim, Rehab Ali, Tabra, Samar abd Alhamed, Saber, Sally, Franklin, Genny, and Mokbel, Abir

Published
2023
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8. Developing a mortality risk prediction model using data of 3663 hospitalized COVID-19 patients: a retrospective cohort study in an Egyptian University Hospital

Author

Kandil, Sahar, Tharwat, Ayman I., Mohsen, Sherief M., Eldeeb, Mai, Abdallah, Waleed, Hilal, Amr, Sweed, Hala, Mortada, Mohamed, Arif, Elham, Ahmed, Tarek, Elshafie, Ahmed, Youssef, Tarek, Zaki, Mohamed, El-Gendy, Yasmin, Ebied, Essam, Hamad, Safwat, Habil, Ihab, Dabbous, Hany, El-Said, Amr, Mostafa, Yasser, Girgis, Samia, Mansour, Ossama, El-Anwar, Ali, Omar, Ashraf, Saleh, Ayman, and El-Meteini, Mahmoud

Published
2023
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9. Egyptian evidence-based consensus on clinical practice recommendations for the management of Kawasaki disease

Author

El Miedany, Yasser, Salah, Samia, Lotfy, Hala M., Abu-Zaid, Mohammed Hassan, Mohamed, Sally S., Maher, Sheren Esam, El Gaafary, Maha, Abdulhady, Hala, Farag, Yomna, Eissa, Mervat, Radwan, Ahmed, Medhat, Basma M., El Mikkawy, Dalia M. E., Hassan, Waleed A., Mosa, Doaa Mosad, El Deriny, Ghada, Mortada, Mohamed, Osman, Naglaa S., Fouad, Nermeen Ahmed, Amer, Youmna Ahmed, Nasef, Samah Ismail, Abushady, Hend, Galal, Salwa, El-Latif, Eiman Abd, Maria, Dina, Shabana, Ahmed H., and Tabra, Samar AbdAlhamed

Published
2023
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10. Standardization of interstitial lung disease assessment by ultrasound: results from a Delphi process and web-reliability exercise by the OMERACT ultrasound working group

Author

Delle Sedie, Andrea, Terslev, Lene, Bruyn, George A.W., Cazenave, Tomas, Chrysidis, Stavros, Diaz, Mario, Di Carlo, Marco, Frigato, Marilena, Gargani, Luna, Gutierrez, Marwin, Hocevar, Alojzija, Iagnocco, Annamaria, Juche, Aaron, Keen, Helen, Mandl, Peter, Naredo, Esperanza, Mortada, Mohamed, Pineda, Carlos, Karalilova, Rositsa, Porta, Francesco, Ravagnani, Viviana, Scirè, Carlo, Serban, Teodora, Smith, Kate, Stoenoiu, Maria S., Tardella, Marika, Torralba, Karina, Wakefield, Richard, and D'Agostino, Maria Antonietta

Published
2024
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11. Development and validation of an OMERACT ultrasound scoring system for the extent of calcium pyrophosphate crystal deposition at the joint level and patient level

Author

Sirotti, Silvia, Terslev, Lene, Filippucci, Emilio, Iagnocco, Annamaria, Moller, Ingrid, Naredo, Esperanza, Vreju, Florentin A, Adinolfi, Antonella, Becce, Fabio, Hammer, Hilde Berner, Cazenave, Tomas, Cipolletta, Edoardo, Christiansen, Sara Nysom, Delle Sedie, Andrea, Diaz, Mario, Figus, Fabiana, Mandl, Peter, MacCarter, Daryl, Mortada, Mohamed A, Mouterde, Gael, Porta, Francesco, Reginato, Anthony M, Schmidt, Wolfgang A, Serban, Teodora, Wakefield, Richard J, Zufferey, Pascal, Sarzi-Puttini, Piercarlo, Zanetti, Anna, Damiani, Arianna, Pineda, Carlos, Keen, Helen I, D'Agostino, Maria Antonietta, and Filippou, Georgios

Published
2023
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12. Egyptian evidence-based consensus on clinical practice recommendations for the management of lupus nephritis

Author

El Miedany, Yasser, Kamel, Nadia Salah, Abu-Zaid, Mohammed Hassan, El Hadidi, Khaled, Mahmoud, Geilan Abdelmoneim, Sarhan, Eman, El Gaafary, Maha, Abdel-Nasser, Ahmed, Abualfadl, Esam M., Azim, Atef Abdel, Fathi, Nihal Ahmed, Mokbel, Abir, Hassan, Waleed, Tabra, Samar Abd Alhamed, Eissa, Mervat, Mortada, Mohamed, Fouad, Nermeen Ahmed, Elnemr, Rehab, Mansour, Ahmed Ezzat, Elaraby, Ismail, Medhat, Basma M., Mohamed, Sally S., Abdelradi, Eman Ragab, Ibrahim, Rehab Ali, and Saber, Sally

Published
2022
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16. Psoriatic arthritis treatment to the target: a consensus, evidence-based clinical practice recommendations for the management of psoriatic arthritis and its concomitant clinical manifestations

Author

El Miedany, Yasser, El Gaafary, Maha, GadAllah, Naglaa, Mansour, Mona, Fathy, Nihal, Hassan, Waleed, Mortada, Mohamed, Galal, Salwa, Eissa, Mervat, Tabra, Samar Abdelhamed, Foad, Nermeen, Ali, Rehab, Medhat, Basma, El Olemy, Gehan, Adel, Yasmin, Ghaleb, Rasha, El-Latif, Eiman Abd, Saber, Sally, Elkaraly, Nourhan, and Abu-Zaid, Mohammed Hassan

Published
2022
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17. Egyptian recommendations for treating to target of lupus nephritis: an evidence-based consensus on clinical practice recommendations for the management of lupus nephritis and pregnancy

Author

El Miedany, Yasser, Kamel, Nadia Salah, Abu-Zaid, Mohammed Hassan, El Hadidi, Khaled, Mahmoud, Geilan Abdelmoneim, El Gaafary, Maha, Sarhan, Eman, Abdel-Nasser, Ahmed, Abualfadl, Esam M., Azim, Atef Abdel, Fathi, Nihal Ahmed, Mokbel, Abir, Hassan, Waleed, Eissa, Mervat, Tabra, Samar Abd Alhamed, Mortada, Mohamed, Fouad, Nermeen Ahmed, Elnemr, Rehab, Mansour, Ahmed Ezzat, Elaraby, Ismail, Medhat, Basma M., Mohamed, Sally S., Abdelradi, Eman Ragab, Ibrahim, Rehab Ali, and Saber, Sally

Published
2022
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20. Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis

Author

Naredo, Esperanza, primary, D Agostino, Maria Antonietta, additional, Terslev, Lene, additional, Pineda, Carlos, additional, Miguel, M Isabel, additional, Blasi, Joan, additional, Bruyn, George A, additional, Kortekaas, Marion C, additional, Mandl, Peter, additional, Nestorova, Rodina, additional, Szkudlarek, Marcin, additional, Todorov, Plamen, additional, Vlad, Violeta, additional, Wong, Priscilla, additional, Bakewell, Catherine, additional, Filippucci, Emilio, additional, Zabotti, Alen, additional, Micu, Mihaela, additional, Vreju, Florentin, additional, Mortada, Mohamed, additional, Mendonça, José Alexandre, additional, Guillen-Astete, Carlos A, additional, Olivas-Vergara, Otto, additional, Iagnocco, Annamaria, additional, Hanova, Petra, additional, Tinazzi, Ilaria, additional, Balint, Peter V, additional, Aydin, Sibel Zehra, additional, Kane, David, additional, Keen, Helen, additional, Kaeley, Gurjit S, additional, and Möller, Ingrid, additional

Published
2024
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21. African League Against Rheumatism (AFLAR) preliminary recommendations on the management of rheumatic diseases during the COVID-19 pandemic

Author

Akintayo, Richard Oluyinka, Bahiri, Rachid, El Miedany, Yasser, Olaosebikan, Hakeem, Kalla, Asgar Ali, Adebajo, Adewale Olukayode, Migowa, Angela Nyangore, Slimani, Samy, Koussougbo, Ouma Devi, Kawther, Ben Abdelghani, Akpabio, Akpabio Akanimo, Ghozlani, Imad, Dey, Dzifa, Hassan, Waleed A., Govind, Nimmisha, Makan, Kavita, Mohamed, Abdelgaffar, Genga, Eugene Kalman, Ghassem, Mohamed Khattry Ahmed, Mortada, Mohamed, Hamdi, Wafa, Wabi, Moudjib O., Tikly, Mohammed, Ngandeu-Singwe, Madeleine, and Scott, Christian

Published
2021
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22. Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis

Author

Naredo, Esperanza, D'Agostino, Maria Antonietta, Terslev, Lene, Pineda, Carlo, Miguel, M Isabel, Blasi, Joan, Bruyn, George A, Kortekaas, Marion C, Mandl, Peter, Nestorova, Rodina, Szkudlarek, Marcin, Todorov, Plamen, Vlad, Violeta, Wong, Priscilla, Bakewell, Catherine, Filippucci, Emilio, Zabotti, Alen, Micu, Mihaela, Vreju, Florentin, Mortada, Mohamed, Mendonça, José Alexandre, Guillen-Astete, Carlos A, Olivas-Vergara, Otto, Iagnocco, Annamaria, Hanova, Petra, Tinazzi, Ilaria, Balint, Peter V, Aydin, Sibel Zehra, Kane, David, Keen, Helen, Kaeley, Gurjit S, Möller, Ingrid, D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060), Naredo, Esperanza, D'Agostino, Maria Antonietta, Terslev, Lene, Pineda, Carlo, Miguel, M Isabel, Blasi, Joan, Bruyn, George A, Kortekaas, Marion C, Mandl, Peter, Nestorova, Rodina, Szkudlarek, Marcin, Todorov, Plamen, Vlad, Violeta, Wong, Priscilla, Bakewell, Catherine, Filippucci, Emilio, Zabotti, Alen, Micu, Mihaela, Vreju, Florentin, Mortada, Mohamed, Mendonça, José Alexandre, Guillen-Astete, Carlos A, Olivas-Vergara, Otto, Iagnocco, Annamaria, Hanova, Petra, Tinazzi, Ilaria, Balint, Peter V, Aydin, Sibel Zehra, Kane, David, Keen, Helen, Kaeley, Gurjit S, Möller, Ingrid, and D'Agostino, Maria Antonietta (ORCID:0000-0002-5347-0060)

Abstract

Objectives The main objective was to generate a GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis and to test its reliability. To this end, we assessed the validity, feasibility and applicability of ultrasound assessment of finger entheses to incorporate them into the scoring system.Methods The study consisted of a stepwise process. First, in cadaveric specimens, we identified enthesis sites of the fingers by ultrasound and gross anatomy, and then verified presence of entheseal tissue in histological samples. We then selected the entheses to be incorporated into a dactylitis scoring system through a Delphi consensus process among international experts. Next, we established and defined the ultrasound components of dactylitis and their scoring systems using Delphi methodology. Finally, we tested the interobserver and intraobserver reliability of the consensus- based scoring systemin patients with psoriatic dactylitis.Results 32 entheses were identified in cadaveric fingers. The presence of entheseal tissues was confirmed in all cadaveric samples. Of these, following the consensus process, 12 entheses were selected for inclusion in GLOUDAS. Ultrasound components of GLOUDAS agreed on through the Delphi process were synovitis, tenosynovitis, enthesitis, subcutaneous tissue inflammation and periextensor tendon inflammation. The scoring system for each component was also agreed on. Interobserver reliability was fair to good (kappa 0.39-0.71) and intraobserver reliability good to excellent (kappa 0.80-0.88) for dactylitis components. Interobserver and intraobserver agreement for the total B-mode and Doppler mode scores (sum of the scores of the individual abnormalities) were excellent (interobserver intraclass correlation coefficient (ICC) 0.98 for B-mode and 0.99 for Doppler mode; intraobserver ICC 0.98 for both modes).Conclusions We have produced a consensus-driven ultrasound dactylitis scoring system that has shown acceptable interobserver relia

Published
2024

23. Egyptian consensus on treat-to-target approach for osteoporosis: a clinical practice guideline from the Egyptian Academy of bone health and metabolic bone diseases

Author

El Miedany, Yasser, Abu-Zaid, Mohammed Hassan, El Gaafary, Maha, El Naby, Mona Mansour Hasab, Fathi, Nihal, Saber, Heba Gamal, Hassan, Waleed, Eissa, Mervat, Mohannad, Nevine, Khaled, Henaz, Mortada, Mohamed, Nasef, Samah Ismail, Galal, Salwa, Ghaleb, Rasha, Tabra, Samar Abd Alhamed, Mohamed, Sally S., Medhat, Basma M., Aly, Hany M., Elolemy, Gehan, Fouad, Nermeen Ahmed, Ganeb, Sahar S., Adel, Yasmin, Ibrahim, Medhat Mohiy Eldin, Farouk, Osama, and Gadallah, Naglaa

Published
2021
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26. E07 Development of a coordinated transitional care program on adolescents with juvenile idiopathic arthritis: looking through the patient lens

Author

Miedany, Yasser El, primary, Abu-Zaid, Mohammed Hassan, additional, Eissa, Mervat, additional, Hassan, Waleed A, additional, Mortada, Mohamed, additional, Tabra, Samar Abd Alhamed, additional, Mohamed, Sally S, additional, Maher, Sheren Esam, additional, Gaafary, Maha El, additional, Medhat, Basma M, additional, Mosa, Doaa Mosad, additional, Fouad, Nermeen Ahmed, additional, Amer, Youmna Ahmed, additional, Nasef, Samah Ismail, additional, Shalaby, Radwa H, additional, Adel, Yasmin, additional, Elkhalek, Reham Abd, additional, Mahgoub, Marwa Yahia, additional, and Lotfy, Hala M, additional

Published
2023
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31. Ultrasonography of Inflammatory and Structural Lesions in Hand Osteoarthritis: An Outcome Measures in Rheumatology Agreement and Reliability Study

Author

Mathiessen, Alexander, Hammer, Hilde B., Terslev, Lene, Kortekaas, Marion, D'Agostino, Maria A., Haugen, Ida K., Bruyn, George, Filippou, Georgios, Filippucci, Emilio, Kloppenburg, Margreet, Mancarella, Luana, Mandl, Peter, Möller, Ingrid, Mortada, Mohamed A., Naredo, Esperanza, Sedie, Andrea Delle, Sexton, Joseph, Wittoek, Ruth, Iagnocco, Annamaria, Ellegaard, Karen, Gandjbakhch, Frederique, Keen, Helen, Hammer, Hilde Berner, D'Agostino, Maria Antonietta, Vlychou, Marianna, and Damjanov, Nemanja

Subjects
medicine.medical_specialty, business.industry, Cartilage, Ultrasound, Joint effusion, Rheumatology, medicine.anatomical_structure, Internal medicine, medicine, Ultrasonography, medicine.symptom, business, Nuclear medicine, Kappa, Hand osteoarthritis, Reliability (statistics)
Abstract

Objective To standardize and assess the reliability of ultrasonographic assessment of inflammatory and structural lesions in patients with hand osteoarthritis (OA). Methods The Outcome Measures in Rheumatology Ultrasound Working Group selected synovial hypertrophy (SH), joint effusion (JE), and power Doppler (PD) signals as the main inflammatory lesions in hand OA, and suggested osteophytes in the scapho-trapezio-trapezoid (STT) and cartilage defects in the proximal interphalangeal (PIP) joints as novel additions to previous structural scoring systems. A complementary imaging atlas provided detailed examples of the scores. A reliability exercise of static images was performed for the inflammatory features, followed by a patient-based exercise with 6 sonographers testing inflammatory and structural features in 12 hand OA patients. We used Cohen's kappa for intrareader and Light's kappa for interreader reliability for all features except PD, in which prevalence-adjusted bias-adjusted kappa (PABAK) was applied. Percentage agreement was also assessed. Results The web-based reliability exercise demonstrated substantial intra- and interreader reliability for all inflammatory features (kappa > 0.64). In the patient-based exercise, intra- and interreader reliability, respectively, varied: SH kappa = 0.73 and 0.45; JE kappa = 0.70 and 0.55; PD PABAK = 0.90 and 0.88; PIP joint cartilage kappa = 0.56 and 0.45; and STT osteophytes kappa = 0.62 and 0.36. Percentage close agreement was high for all features (>85%). Conclusion With ultrasound, substantial to excellent intrareader reliability was found for inflammatory features of hand OA. Interreader reliability was moderate, but overall high close agreement between readers suggests that better reliability is achievable after further training. Assessment of osteophytes in the STT joint and cartilage in the PIP joints achieved less reliability and the latter is not endorsed.

Published
2022

32. Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study.

Author

UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Trickey, Jeanette, Sahbudin, Ilfita, Ammitzbøll-Danielsen, Mads, Azzolin, Irene, Borst, Carina, Bortoluzzi, Alessandra, Bruyn, George Aw, Carron, Philippe, Ciurtin, Coziana, Filippou, Georgios, Fliciński, Jacek, Fodor, Daniela, Gouze, Hélène, Gutierrez, Marwin, Hammer, Hilde Berner, Hauge, Ellen-Margrethe, Iagnocco, Annamaria, Ikeda, Kei, Karalilova, Rositsa, Keen, Helen Isobel, Kortekaas, Marion, La Paglia, Giuliana, Leon, Gustavo, Mandl, Peter, Maruseac, Mihaela, Milchert, Marcin, Mortada, Mohamed Atia, Naredo, Esperanza, Ohrndorf, Sarah, Pineda, Carlos, Rasch, Mads Nyhuus Bendix, Reátegui-Sokolova, Cristina, Sakellariou, Garifallia, Serban, Teodora, Sifuentes-Cantú, Cesar A, Stoenoiu, Maria S, Suzuki, Takeshi, Terslev, Lene, Tinazzi, Ilaria, Vreju, Florentin Ananu, Wittoek, Ruth, D'Agostino, Maria-Antonietta, Filer, Andrew, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Trickey, Jeanette, Sahbudin, Ilfita, Ammitzbøll-Danielsen, Mads, Azzolin, Irene, Borst, Carina, Bortoluzzi, Alessandra, Bruyn, George Aw, Carron, Philippe, Ciurtin, Coziana, Filippou, Georgios, Fliciński, Jacek, Fodor, Daniela, Gouze, Hélène, Gutierrez, Marwin, Hammer, Hilde Berner, Hauge, Ellen-Margrethe, Iagnocco, Annamaria, Ikeda, Kei, Karalilova, Rositsa, Keen, Helen Isobel, Kortekaas, Marion, La Paglia, Giuliana, Leon, Gustavo, Mandl, Peter, Maruseac, Mihaela, Milchert, Marcin, Mortada, Mohamed Atia, Naredo, Esperanza, Ohrndorf, Sarah, Pineda, Carlos, Rasch, Mads Nyhuus Bendix, Reátegui-Sokolova, Cristina, Sakellariou, Garifallia, Serban, Teodora, Sifuentes-Cantú, Cesar A, Stoenoiu, Maria S, Suzuki, Takeshi, Terslev, Lene, Tinazzi, Ilaria, Vreju, Florentin Ananu, Wittoek, Ruth, D'Agostino, Maria-Antonietta, and Filer, Andrew

Abstract

This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.

Published
2022

33. Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjögren's syndrome:an OMERACT reliability exercise

Author

Hočevar, Alojzija, Bruyn, George A., Terslev, Lene, De Agustin, Juan Jose, MacCarter, Daryl, Chrysidis, Stavros, Collado, Paz, Dejaco, Christian, Fana, Viktoria, Filippou, Georgios, Finzel, Stephanie, Gandjbakhch, Frederique, Hanova, Petra, Hammenfors, Daniel, Hernandez-Diaz, Cristina, Iagnocco, Annamaria, Mortada, Mohamed Atia, Inanc, Nevsun, Naredo, Esperanza, Ohrndorf, Sarah, Perko, Nejc, Schmidt, Wolfgang A., Tamborrini, Giorgio, Tomšič, Matija, Chary-Valckenaere, Isabelle, Zabotti, Alen, Keen, Helen I., Pineda, Carlos, D'Agostino, Maria Antonietta, Jousse-Joulin, Sandrine, Hočevar, Alojzija, Bruyn, George A., Terslev, Lene, De Agustin, Juan Jose, MacCarter, Daryl, Chrysidis, Stavros, Collado, Paz, Dejaco, Christian, Fana, Viktoria, Filippou, Georgios, Finzel, Stephanie, Gandjbakhch, Frederique, Hanova, Petra, Hammenfors, Daniel, Hernandez-Diaz, Cristina, Iagnocco, Annamaria, Mortada, Mohamed Atia, Inanc, Nevsun, Naredo, Esperanza, Ohrndorf, Sarah, Perko, Nejc, Schmidt, Wolfgang A., Tamborrini, Giorgio, Tomšič, Matija, Chary-Valckenaere, Isabelle, Zabotti, Alen, Keen, Helen I., Pineda, Carlos, D'Agostino, Maria Antonietta, and Jousse-Joulin, Sandrine

Abstract

OBJECTIVE: The aim of this exercise from the OMERACT Ultrasound subgroup on Sjögren's syndrome was to develop and assess the reliability of a consensus-based semiquantitative colour Doppler US scoring system for pathologic salivary gland vascularization in patients with primary Sjögren's syndrome (pSS). METHODS: Using the Delphi method, a colour Doppler semiquantitative scoring system for vascularization of bilateral parotid and submandibular glands was developed and tested in static images and on patients (9 pSS patients and 9 sonographers). Intra-reader and inter-reader reliability of grading the salivary glands were computed by weighted Cohen and Light's kappa analysis, respectively. RESULTS: The consensus-based semiquantitative score was: grade 0, no visible vascular signals; grade 1, focal, dispersed vascular signals; grade 2, diffuse vascular signals detected in <50% of the gland; grade 3, diffuse vascular signals in >50% of the gland. In static images, the intra- and inter-reader reliability showed excellent kappa values (95% CI) of 0.90 (0.87, 0.93) and 0.80 (0.74, 0.84), respectively, for all four salivary glands together. In patients, the intra- and inter-reader reliability for all four salivary glands together was kappa = 0.84 (0.73, 0.92) and 0.70 (0.64, 0.76), respectively. CONCLUSION: The consensus-based colour Doppler US scoring for the evaluation of salivary gland vascularization in pSS showed a good inter-reader reliability and excellent intra-reader reliability in static images and in patients. The clinical application of the developed scoring system should be tested in clinical settings.

Published
2022

34. Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range:OMERACT ultrasound minimal disease study

Author

Trickey, Jeanette, Sahbudin, Ilfita, Ammitzbøll-Danielsen, Mads, Azzolin, Irene, Borst, Carina, Bortoluzzi, Alessandra, Bruyn, George A. W., Carron, Philippe, Ciurtin, Coziana, Filippou, Georgios, Fliciński, Jacek, Fodor, Daniela, Gouze, Hélène, Gutierrez, Marwin, Hammer, Hilde Berner, Hauge, Ellen Margrethe, Iagnocco, Annamaria, Ikeda, Kei, Karalilova, Rositsa, Keen, Helen Isobel, Kortekaas, Marion, La Paglia, Giuliana, Leon, Gustavo, Mandl, Peter, Maruseac, Mihaela, Milchert, Marcin, Mortada, Mohamed Atia, Naredo, Esperanza, Ohrndorf, Sarah, Pineda, Carlos, Rasch, Mads Nyhuus Bendix, Reátegui-Sokolova, Cristina, Sakellariou, Garifallia, Serban, Teodora, Sifuentes-Cantú, Cesar A., Stoenoiu, Maria S., Suzuki, Takeshi, Terslev, Lene, Tinazzi, Ilaria, Vreju, Florentin Ananu, Wittoek, Ruth, D'Agostino, Maria-Antonietta, Filer, Andrew, Trickey, Jeanette, Sahbudin, Ilfita, Ammitzbøll-Danielsen, Mads, Azzolin, Irene, Borst, Carina, Bortoluzzi, Alessandra, Bruyn, George A. W., Carron, Philippe, Ciurtin, Coziana, Filippou, Georgios, Fliciński, Jacek, Fodor, Daniela, Gouze, Hélène, Gutierrez, Marwin, Hammer, Hilde Berner, Hauge, Ellen Margrethe, Iagnocco, Annamaria, Ikeda, Kei, Karalilova, Rositsa, Keen, Helen Isobel, Kortekaas, Marion, La Paglia, Giuliana, Leon, Gustavo, Mandl, Peter, Maruseac, Mihaela, Milchert, Marcin, Mortada, Mohamed Atia, Naredo, Esperanza, Ohrndorf, Sarah, Pineda, Carlos, Rasch, Mads Nyhuus Bendix, Reátegui-Sokolova, Cristina, Sakellariou, Garifallia, Serban, Teodora, Sifuentes-Cantú, Cesar A., Stoenoiu, Maria S., Suzuki, Takeshi, Terslev, Lene, Tinazzi, Ilaria, Vreju, Florentin Ananu, Wittoek, Ruth, D'Agostino, Maria-Antonietta, and Filer, Andrew

Abstract

OBJECTIVES: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. METHODS: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. RESULTS: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. CONCLUSIONS: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA.

Published
2022

39. Ultrasonography of inflammatory and structural lesions in hand osteoarthritis : an OMERACT agreement and reliability study

Author

Mathiessen, Alexander, Hammer, Hilde B., Terslev, Lene, Kortekaas, Marion C., D’Agostino, Maria A., Haugen, Ida K., Bruyn, George A., Filippou, Georgios, Filippucci, Emilio, Kloppenburg, Margreet, Mancarella, Luana, Mandl, Peter, Möller, Ingrid, Mortada, Mohamed A., Naredo, Esperanza, Delle Sedie, Andrea, Sexton, Joseph, Wittoek, Ruth, Iagnocco, Annamaria, Ellegaard, Karen, and The OMERACT Ultrasound working Group, [missing]

Subjects
hand osteoarthritis, SCORING SYSTEM, SYNOVITIS, FEATURES, PROGRESSION, ultrasonography, PREVALENCE, outcome measures, Rheumatology, Medicine and Health Sciences, ARTHRITIS, BONE EROSIONS, CLINICAL-TRIALS, ULTRASOUND, ASSOCIATIONS
Abstract

Objective To standardize and assess the reliability of ultrasonographic assessment of inflammatory and structural lesions in patients with hand osteoarthritis (OA). Methods The Outcome Measures in Rheumatology Ultrasound Working Group selected synovial hypertrophy (SH), joint effusion (JE), and power Doppler (PD) signals as the main inflammatory lesions in hand OA, and suggested osteophytes in the scapho-trapezio-trapezoid (STT) and cartilage defects in the proximal interphalangeal (PIP) joints as novel additions to previous structural scoring systems. A complementary imaging atlas provided detailed examples of the scores. A reliability exercise of static images was performed for the inflammatory features, followed by a patient-based exercise with 6 sonographers testing inflammatory and structural features in 12 hand OA patients. We used Cohen's kappa for intrareader and Light's kappa for interreader reliability for all features except PD, in which prevalence-adjusted bias-adjusted kappa (PABAK) was applied. Percentage agreement was also assessed. Results The web-based reliability exercise demonstrated substantial intra- and interreader reliability for all inflammatory features (kappa > 0.64). In the patient-based exercise, intra- and interreader reliability, respectively, varied: SH kappa = 0.73 and 0.45; JE kappa = 0.70 and 0.55; PD PABAK = 0.90 and 0.88; PIP joint cartilage kappa = 0.56 and 0.45; and STT osteophytes kappa = 0.62 and 0.36. Percentage close agreement was high for all features (>85%). Conclusion With ultrasound, substantial to excellent intrareader reliability was found for inflammatory features of hand OA. Interreader reliability was moderate, but overall high close agreement between readers suggests that better reliability is achievable after further training. Assessment of osteophytes in the STT joint and cartilage in the PIP joints achieved less reliability and the latter is not endorsed.

Published
2022

40. Different Patterns of Juvenile Idiopathic Arthritis in Zagazig University Hospitals

Author

Almalky, Mohamed Abd-Elkader, Rasheed, Ehab Mahmoud, Mortada, Mohamed Attia, and Ayyad, Khairia Mohamed

Subjects
musculoskeletal diseases, Juvenile idiopathic arthritis, Pediatric rheumatic diseases, skin and connective tissue diseases
Abstract

Background: Pediatric rheumatic diseases can cause considerable disease burden to children and their families. They are associated with the potential for physical disability, diminished quality of life and significant direct and indirect costs. Objective: We aimed to describe the clinical spectrum and the frequencies and different patterns of Juvenile idiopathic arthritis (JIA) in children in Zagazig University Hospitals. Patients and methods: A cross-sectional study included 68 cases with Juvenile idiopathic arthritis < 16 years. The study was conducted over two years from December 2017 to December 2019. Investigations as complete blood count,C reactive protein, antinuclear antibody (ANA), rheumatoid factor (RF), complement C3 & C4, creatine phosphokinase, and EMG. Management and treatment plans were achieved and data about the results were collected. Results: Most of patients diagnosed with rheumatological diseases were females. Oligoarticular JIA was the commonest subtype of JIA in our study followed by polyarticular then systemic onset type. NSAIDs was the commonest drug used by JIA patients followed by methotrexate then corticosteroids. Conclusion: Early diagnosis and effective management of these children is essential so that they can lead a normal or near normal life especially in patients with rheumatological diseases with chronic morbidity as JIA.

Published
2021

42. Consensus Evidence-Based Clinical Practice Recommendations for the Diagnosis and Treat-To-Target Management of Osteoporosis in Chronic Kidney Disease Stages G4-G5D and Post-transplantation: An Initiative of Egyptian Academy of Bone Health

Author

El Miedany, Yasser, primary, Gadallah, Naglaa Ali, additional, Sarhan, Eman, additional, Toth, Mathias, additional, Hasab El Naby, Mona Mansour, additional, Elwy, Mohamed, additional, Ganeb, Sahar, additional, El Gaafary, Maha, additional, Mortada, Mohamed, additional, Nasef, Samah Ismail, additional, Mohannad, Nevine, additional, Mahran, Safaa Ali, additional, Abu-Zaid, Mohammed Hassan, additional, Eissa, Mervat, additional, Hassan, Waleed, additional, Medhat, Basma M, additional, Ghaleb, Rasha, additional, Tabra, Samar Abdelhamed, additional, Saber, Heba Gamal, additional, Ibrahim, Rehab Ali, additional, Saber, Sally, additional, and Galal, Salwa, additional

Published
2022
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44. Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjögren’s syndrome: an OMERACT reliability exercise

Author

Hočevar, Alojzija, primary, Bruyn, George A, additional, Terslev, Lene, additional, De Agustin, Juan Jose, additional, MacCarter, Daryl, additional, Chrysidis, Stavros, additional, Collado, Paz, additional, Dejaco, Christian, additional, Fana, Viktoria, additional, Filippou, Georgios, additional, Finzel, Stephanie, additional, Gandjbakhch, Frederique, additional, Hanova, Petra, additional, Hammenfors, Daniel, additional, Hernandez-Diaz, Cristina, additional, Iagnocco, Annamaria, additional, Mortada, Mohamed Atia, additional, Inanc, Nevsun, additional, Naredo, Esperanza, additional, Ohrndorf, Sarah, additional, Perko, Nejc, additional, Schmidt, , Wolfgang A, additional, Tamborrini, Giorgio, additional, Tomšič, Matija, additional, Chary-Valckenaere, Isabelle, additional, Zabotti, Alen, additional, Keen, Helen I, additional, Pineda, Carlos, additional, D’Agostino, Maria-Antonietta, additional, and Jousse-Joulin, Sandrine, additional

Published
2021
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46. Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study

Author

Trickey, Jeanette, primary, Sahbudin, Ilfita, additional, Ammitzbøll-Danielsen, Mads, additional, Azzolin, Irene, additional, Borst, Carina, additional, Bortoluzzi, Alessandra, additional, Bruyn, George AW, additional, Carron, Philippe, additional, Ciurtin, Coziana, additional, Filippou, Georgios, additional, Fliciński, Jacek, additional, Fodor, Daniela, additional, Gouze, Hélène, additional, Gutierrez, Marwin, additional, Hammer, Hilde Berner, additional, Hauge, Ellen-Margrethe, additional, Iagnocco, Annamaria, additional, Ikeda, Kei, additional, Karalilova, Rositsa, additional, Keen, Helen Isobel, additional, Kortekaas, Marion, additional, La Paglia, Giuliana, additional, Leon, Gustavo, additional, Mandl, Peter, additional, Maruseac, Mihaela, additional, Milchert, Marcin, additional, Mortada, Mohamed Atia, additional, Naredo, Esperanza, additional, Ohrndorf, Sarah, additional, Pineda, Carlos, additional, Rasch, Mads Nyhuus Bendix, additional, Reátegui-Sokolova, Cristina, additional, Sakellariou, Garifallia, additional, Serban, Teodora, additional, Sifuentes-Cantú, Cesar A, additional, Stoenoiu, Maria S, additional, Suzuki, Takeshi, additional, Terslev, Lene, additional, Tinazzi, Ilaria, additional, Vreju, Florentin Ananu, additional, Wittoek, Ruth, additional, D'Agostino, Maria-Antonietta, additional, and Filer, Andrew, additional

Published
2021
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48. Ultrasonography of Inflammatory and Structural Lesions in Hand Osteoarthritis: An OMERACT Agreement and Reliability Study

Author

Mathiessen, Alexander, Hammer, Hilde B, Terslev, Lene, Kortekaas, Marion C, D'Agostino, Maria Antonietta, Haugen, Ida K, Bruyn, George A, Filippou, Georgios, Filippucci, Emilio, Kloppenburg, Margreet, Mancarella, Luana, Mandl, Peter, Möller, Ingrid, Mortada, Mohamed A, Naredo, Esperanza, Delle Sedie, Andrea, Sexton, Joseph, Wittoek, Ruth, Iagnocco, Annamaria, and Ellegaard, Karen

Subjects
outcome measures, Settore MED/16 - REUMATOLOGIA, Hand osteoarthritis, ultrasonography
Published
2021

49. Very low prevalence of ultrasound-detected tenosynovial abnormalities in healthy subjects throughout the age range: OMERACT ultrasound minimal disease study

Author

Trickey, Jeanette, Sahbudin, Ilfita, Ammitzbøll-Danielsen, Mad, Azzolin, Irene, Borst, Carina, Bortoluzzi, Alessandra, Bruyn, George Aw, Carron, Philippe, Ciurtin, Coziana, Filippou, Georgio, Fliciński, Jacek, Fodor, Daniela, Gouze, Hélène, Gutierrez, Marwin, Hammer, Hilde Berner, Hauge, Ellen-Margrethe, Iagnocco, Annamaria, Ikeda, Kei, Karalilova, Rositsa, Keen, Helen Isobel, Kortekaas, Marion, La Paglia, Giuliana, Leon, Gustavo, Mandl, Peter, Maruseac, Mihaela, Milchert, Marcin, Mortada, Mohamed Atia, Naredo, Esperanza, Ohrndorf, Sarah, Pineda, Carlo, Rasch, Mads Nyhuus Bendix, Reátegui-Sokolova, Cristina, Sakellariou, Garifallia, Serban, Teodora, Sifuentes-Cantú, Cesar A, Stoenoiu, Maria S, Suzuki, Takeshi, Terslev, Lene, Tinazzi, Ilaria, Vreju, Florentin Ananu, Wittoek, Ruth, D'Agostino, Maria Antonietta, Filer, Andrew, D'Agostino, Maria-Antonietta (ORCID:0000-0002-5347-0060), Trickey, Jeanette, Sahbudin, Ilfita, Ammitzbøll-Danielsen, Mad, Azzolin, Irene, Borst, Carina, Bortoluzzi, Alessandra, Bruyn, George Aw, Carron, Philippe, Ciurtin, Coziana, Filippou, Georgio, Fliciński, Jacek, Fodor, Daniela, Gouze, Hélène, Gutierrez, Marwin, Hammer, Hilde Berner, Hauge, Ellen-Margrethe, Iagnocco, Annamaria, Ikeda, Kei, Karalilova, Rositsa, Keen, Helen Isobel, Kortekaas, Marion, La Paglia, Giuliana, Leon, Gustavo, Mandl, Peter, Maruseac, Mihaela, Milchert, Marcin, Mortada, Mohamed Atia, Naredo, Esperanza, Ohrndorf, Sarah, Pineda, Carlo, Rasch, Mads Nyhuus Bendix, Reátegui-Sokolova, Cristina, Sakellariou, Garifallia, Serban, Teodora, Sifuentes-Cantú, Cesar A, Stoenoiu, Maria S, Suzuki, Takeshi, Terslev, Lene, Tinazzi, Ilaria, Vreju, Florentin Ananu, Wittoek, Ruth, D'Agostino, Maria Antonietta, Filer, Andrew, and D'Agostino, Maria-Antonietta (ORCID:0000-0002-5347-0060)

Abstract

Objectives: This study aimed to determine the prevalence of ultrasound-detected tendon abnormalities in healthy subjects (HS) across the age range. Methods: Adult HS (age 18-80 years) were recruited in 23 international Outcome Measures in Rheumatology ultrasound centres and were clinically assessed to exclude inflammatory diseases or overt osteoarthritis before undergoing a bilateral ultrasound examination of digit flexors (DFs) 1-5 and extensor carpi ulnaris (ECU) tendons to detect the presence of tenosynovial hypertrophy (TSH), tenosynovial power Doppler (TPD) and tenosynovial effusion (TEF), usually considered ultrasound signs of inflammatory diseases. A comparison cohort of patients with rheumatoid arthritis (RA) was taken from the Birmingham Early Arthritis early arthritis inception cohort. Results: 939 HS and 144 patients with RA were included. The majority of HS (85%) had grade 0 for TSH, TPD and TEF in all DF and ECU tendons examined. There was a statistically significant difference in the proportion of TSH and TPD involvement between HS and subjects with RA (HS vs RA p<0.001). In HS, there was no difference in the presence of ultrasound abnormalities between age groups. Conclusions: Ultrasound-detected TSH and TPD abnormalities are rare in HS and can be regarded as markers of active inflammatory disease, especially in newly presenting RA. Keywords: rheumatoid arthritis; tendinopathy; ultrasonography.

Published
2021

50. Development of a new ultrasound scoring system to evaluate glandular inflammation in Sjögren's syndrome: an OMERACT reliability exercise.

Author

Hočevar, Alojzija, Bruyn, George A, Terslev, Lene, Agustin, Juan Jose De, MacCarter, Daryl, Chrysidis, Stavros, Collado, Paz, Dejaco, Christian, Fana, Viktoria, Filippou, Georgios, Finzel, Stephanie, Gandjbakhch, Frederique, Hanova, Petra, Hammenfors, Daniel, Hernandez-Diaz, Cristina, Iagnocco, Annamaria, Mortada, Mohamed Atia, Inanc, Nevsun, Naredo, Esperanza, and Ohrndorf, Sarah

Subjects
EXPERIMENTAL design, RELIABILITY (Personality trait), STATISTICS, ULTRASONIC imaging, CONFIDENCE intervals, INFLAMMATION, RESEARCH methodology, DESCRIPTIVE statistics, SJOGREN'S syndrome, SALIVARY glands, DELPHI method
Abstract

Objective The aim of this exercise from the OMERACT Ultrasound subgroup on Sjögren's syndrome was to develop and assess the reliability of a consensus-based semiquantitative colour Doppler US scoring system for pathologic salivary gland vascularization in patients with primary Sjögren's syndrome (pSS). Methods Using the Delphi method, a colour Doppler semiquantitative scoring system for vascularization of bilateral parotid and submandibular glands was developed and tested in static images and on patients (9 pSS patients and 9 sonographers). Intra-reader and inter-reader reliability of grading the salivary glands were computed by weighted Cohen and Light's kappa analysis, respectively. Results The consensus-based semiquantitative score was: grade 0, no visible vascular signals; grade 1, focal, dispersed vascular signals; grade 2, diffuse vascular signals detected in <50% of the gland; grade 3, diffuse vascular signals in >50% of the gland. In static images, the intra- and inter-reader reliability showed excellent kappa values (95% CI) of 0.90 (0.87, 0.93) and 0.80 (0.74, 0.84), respectively, for all four salivary glands together. In patients, the intra- and inter-reader reliability for all four salivary glands together was kappa = 0.84 (0.73, 0.92) and 0.70 (0.64, 0.76), respectively. Conclusion The consensus-based colour Doppler US scoring for the evaluation of salivary gland vascularization in pSS showed a good inter-reader reliability and excellent intra-reader reliability in static images and in patients. The clinical application of the developed scoring system should be tested in clinical settings. [ABSTRACT FROM AUTHOR]

Published
2022
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