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3. Human milk antibodies to global pathogens reveal geographic and interindividual variations in IgA and IgG

Author

Campo, Joseph J., Seppo, Antti E., Randall, Arlo Z., Pablo, Jozelyn, Hung, Chris, Teng, Andy, Shandling, Adam D., Truong, Johnathon, Oberai, Amit, Miller, James, Iqbal, Najeeha Talat, Yori, Pablo Penataro, Kukkonen, Anna Kaarina, Kuitunen, Mikael, Guterman, L. Beryl, Morris, Shaun K., Pell, Lisa G., Mahmud, Abdullah Al, Ramakrishan, Girija, Heinz, Eva, Kirkpatrick, Beth D., Faruque, Abu S.G., Haque, Rashidul, Looney, R. John, Kosek, Margaret N., Savilahti, Erkki, Omer, Saad B., Roth, Daniel E., Petri, William A., Jr., and Jarvinen, Kirsi M.

Subjects
Breast milk -- Composition -- Analysis, Immunoglobulin A -- Analysis, Immunoglobulin G -- Analysis, Health care industry
Abstract

BACKGROUND. The use of high-throughput technologies has enabled rapid advancement in the knowledge of host immune responses to pathogens. Our objective was to compare the repertoire, protection, and maternal factors associated with human milk antibodies to infectious pathogens in different economic and geographic locations. METHODS. Using multipathogen protein microarrays, 878 milk and 94 paired serum samples collected from 695 women in 5 high and low-to-middle income countries (Bangladesh, Finland, Peru, Pakistan, and the United States) were assessed for specific IgA and IgG antibodies to 1,607 proteins from 30 enteric, respiratory, and bloodborne pathogens. RESULTS. The antibody coverage across enteric and respiratory pathogens was highest in Bangladeshi and Pakistani cohorts and lowest in the U.S. and Finland. While some pathogens induced a dominant IgA response (Campylobacter, Klebsiella, Acinetobacter, Cryptosporidium, and pertussis), others elicited both IgA and IgG antibodies in milk and serum, possibly related to the invasiveness of the infection (Shigella, enteropathogenic E. coli 'EPEC', Streptococcus pneumoniae, Staphylococcus aureus, and Group B Streptococcus). Besides the differences between economic regions and decreases in concentrations over time, human milk IgA and IgG antibody concentrations were lower in mothers with high BMI and higher parity, respectively. In Bangladeshi infants, a higher specific IgA concentration in human milk was associated with delayed time to rotavirus infection, implying protective properties of antirotavirus antibodies, whereas a higher IgA antibody concentration was associated with greater incidence of Campylobacter infection. CONCLUSION. This comprehensive assessment of human milk antibody profiles may be used to guide the development of passive protection strategies against infant morbidity and mortality. FUNDING. Bill and Melinda Gates Foundation grant OPP1172222 (to KMJ); Bill and Melinda Gates Foundation grant OPP1066764 funded the MDIG trial (to DER); University of Rochester CTSI and Environmental Health Sciences Center funded the Rochester Lifestyle study (to RJL); and R01 AI043596 funded PROVIDE (to WAP)., Introduction In 2019, 5.3 million liveborn children died before 5 years of age worldwide, nearly half of whom died from infectious diseases, including lower respiratory infections and diarrhea (1). The [...]

Published
2024
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4. Utilization of a novel mobile application, “HBB Prompt”, to reduce Helping Babies Breathe skills decay

Author

Chan, Natalie Hoi-Man, Merali, Hasan S, Mistry, Niraj, Kealey, Ryan, Campbell, Douglas M, Morris, Shaun K, and Data, Santorino

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Public Health, Health Sciences, Clinical Research, Pediatric, Good Health and Well Being
Abstract

BackgroundHelping Babies Breathe (HBB) is a newborn resuscitation training program designed to reduce neonatal mortality in low- and middle-income countries. However, skills decay after initial training is a significant barrier to sustained impact.ObjectiveTo test whether a mobile app, HBB Prompt, developed with user-centred design, helps improve skills and knowledge retention after HBB training.MethodsHBB Prompt was created during Phase 1 of this study with input from HBB facilitators and providers from Southwestern Uganda recruited from a national HBB provider registry. During Phase 2, healthcare workers (HCWs) in two community hospitals received HBB training. One hospital was randomly assigned as the intervention hospital, where trained HCWs had access to HBB Prompt, and the other served as control without HBB Prompt (NCT03577054). Participants were evaluated using the HBB 2.0 knowledge check and Objective Structured Clinical Exam, version B (OSCE B) immediately before and after training, and 6 months post-training. The primary outcome was difference in OSCE B scores immediately after training and 6 months post-training.ResultsTwenty-nine HCWs were trained in HBB (17 in intervention, 12 in control). At 6 months, 10 HCW were evaluated in intervention and 7 in control. In intervention and control respectively, the median OSCE B scores were: 7 vs. 9 immediately before training, 17 vs. 21 immediately after training, and 12 vs. 13 at 6 months after training. Six months after training, the median difference in OSCE B scores was -3 (IQR -5 to -1) in intervention and -8 (IQR -11 to -6) in control (p = 0.02).ConclusionHBB Prompt, a mobile app created by user-centred design, improved retention of HBB skills at 6 months. However, skills decay remained high 6 months after training. Continued adaptation of HBB Prompt may further improve maintenance of HBB skills.

Published
2023

5. Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage

Author

El Tal, Tala, Morin, Marie-Paule, Morris, Shaun K., Farrar, Daniel S., Berard, Roberta A., Kakkar, Fatima, Moore Hepburn, Charlotte, Baerg, Krista, Beaufils, Camille, Bennett, Terri-Lyn, Benseler, Susanne M., Beaudoin-Bussières, Guillaume, Chan, Kevin, Cyr, Claude, Dahdah, Nagib, Donner, Elizabeth J., Drouin, Olivier, Edjoc, Rojiemiahd, Eljaouhari, Maryem, Embree, Joanne E., Farrell, Catherine, Finzi, Andrés, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin Thibodeau, Melanie, Lang, Bianca, Laxer, Ronald M., Luu, Thuy Mai, McCrindle, Brian W., Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Proulx-Gauthier, Jean-Philippe, Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Thibeault, Roseline, Top, Karina A., Viel-Thériault, Isabelle, Haddad, Elie, Scuccimarri, Rosie, and Yeung, Rae S. M.

Published
2023
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8. Bloodstream Infections in Children Hospitalized for Influenza, the Canadian Immunization Monitoring Program Active

Author

Modler, Jacqueline, Morris, Shaun K., Bettinger, Julie A., Bancej, Christina, Burton, Catherine, Foo, Cheryl, Halperin, Scott A., Jadavji, Taj, Kazmi, Kescha, Sadarangani, Manish, Schober, Tilmann, Papenburg, Jesse, Bridger, Natalie, Top, Karina, Thibeault, Roseline, Moore, Dorothy L., Lebel, Marc, Saux, Nicole Le, Purewal, Rupeena, Sauvé, Laura, and Bullard, Jared

Published
2024
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9. An integrated newborn care kit (iNCK) to save newborn lives and improve health outcomes in Gilgit Baltistan (GB), Pakistan: study protocol for a cluster randomized controlled trial

Author

Fadaleh, Sarah M. Abu, Pell, Lisa G., Yasin, Muhammad, Farrar, Daniel S., Khan, Sher Hafiz, Tanner, Zachary, Paracha, Shariq, Madhani, Falak, Bassani, Diego G., Ahmed, Imran, Soofi, Sajid B., Taljaard, Monica, Spitzer, Rachel F., Bhutta, Zulfiqar A., and Morris, Shaun K.

Published
2023
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10. SARS-CoV-2 infection in technology-dependent children: a multicenter case series

Author

Robinson, Joan, Dewan, Tammie, Morris, Shaun K., Bitnun, Ari, Gill, Peter, Tal, Tala El, Laxer, Ronald M., Yeh, E. Ann, Yea, Carmen, Ulloa-Gutierrez, Rolando, Brenes-Chacon, Helena, Yock-Corrales, Adriana, Ivankovich-Escoto, Gabriela, Soriano-Fallas, Alejandra, Mezerville, Marcela Hernandez-de, Papenburg, Jesse, Lefebvre, Marie-Astrid, Nateghian, Alireza, Aski, Behzad Haghighi, Manafi, Ali, Dwilow, Rachel, Bullard, Jared, Cooke, Suzette, Restivo, Lea, Lopez, Alison, Sadarangani, Manish, Roberts, Ashley, Le Saux, Nicole, Bowes, Jennifer, Purewal, Rupeena, Lautermilch, Janell, Wong, Jacqueline K., Piche, Dominique, Top, Karina A., Foo, Cheryl, Panetta, Luc, Merckx, Joanna, and Barton, Michelle

Published
2023
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11. Bloodstream Infections in Children Hospitalized for Influenza, the Canadian Immunization Monitoring Program Active (IMPACT)

Author

Modler, Jacqueline, Morris, Shaun K., Bettinger, Julie A., Bancej, Christina, Burton, Catherine, Foo, Cheryl, Halperin, Scott A., Jadavji, Taj, Kazmi, Kescha, Sadarangani, Manish, Schober, Tilmann, Papenburg, Jesse, Bridger, Natalie, Top, Karina, Thibeault, Roseline, Moore, Dorothy L., Lebel, Marc, Saux, Nicole Le, Purewal, Rupeena, Sauvé, Laura, and Bullard, Jared

Published
2023
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13. Immunological effects and safety of live rotavirus vaccination after antenatal exposure to immunomodulatory biologic agents: a prospective cohort study from the Canadian Immunization Research Network

Author

Cowan, Juthaporn, Comeau, Jeannette, Derfalvi, Beata, Halperin, Scott A, Burton, Catherine, Suresh, Sneha, Vaudry, Wendy, Finlay, Jane, Dharmani, Poonam, Fitzpatrick, Tiffany, Alsager, Khaled, Sadarangani, Manish, Pham-Huy, Anne, Murguía-Favela, Luis, Morris, Shaun K, Seow, Cynthia H, Piché-Renaud, Pierre-Philippe, Jadavji, Tajdin, Vanderkooi, Otto G, Top, Karina A, and Constantinescu, Cora

Published
2023
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14. Outcomes of immunocompromised children hospitalized for Influenza, 2010-2021, the Canadian Immunization Monitoring Program Active (IMPACT)

Author

Foo, Cheryl, Bridger, Natalie, Halperin, Scott A., Top, Karina, Thibeault, Roseline, Papenburg, Jesse, Lebel, Marc, Le Saux, Nicole, Morris, Shaun K., Kazmi, Kescha, Bullard, Jared, Purewal, Rupeena, Jadavji, Taj, Burton, Catherine, Bettinger, Julie A., Sauvé, Laura, Sadarangani, Manish, Schober, Tilmann, Bancej, Christina, and Modler, Jacqueline

Published
2023
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17. Infants hospitalized for acute COVID-19: disease severity in a multicenter cohort study

Author

Merckx, Joanna, Morris, Shaun K., Bitnun, Ari, Gill, Peter, El Tal, Tala, Laxer, Ronald M., Yeh, Ann, Yea, Carmen, Ulloa-Gutierrez, Rolando, Brenes-Chacon, Helena, Yock-Corrales, Adriana, Ivankovich-Escoto, Gabriela, Soriano-Fallas, Alejandra, Hernandez-de Mezerville, Marcela, Papenburg, Jesse, Lefebvre, Marie-Astrid, Nateghian, Alireza, Haghighi Aski, Behzad, Manafi, Ali, Dwilow, Rachel, Bullard, Jared, Cooke, Suzette, Dewan, Tammie, Restivo, Lea, Lopez, Alison, Sadarangani, Manish, Roberts, Ashley, Barton, Michelle, Petel, Dara, Le Saux, Nicole, Bowes, Jennifer, Purewal, Rupeena, Lautermilch, Janell, Tehseen, Sarah, Bayliss, Ann, Wong, Jacqueline K., Viel-Thériault, Isabelle, Piche, Dominique, Top, Karina A., Leifso, Kirk, Foo, Cheryl, Panetta, Luc, and Robinson, Joan

Published
2022
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18. Risk factors for severe COVID-19 in hospitalized children in Canada: A national prospective study from March 2020–May 2021

Author

Farrar, Daniel S., Drouin, Olivier, Moore Hepburn, Charlotte, Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin Thibodeau, Melanie, Orkin, Julia, Ouldali, Naïm, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Proulx-Gauthier, Jean-Philippe, Purewal, Rupeena, Ricci, Christina, Sadarangani, Manish, Salvadori, Marina I., Thibeault, Roseline, Top, Karina A., Viel-Thériault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Published
2022
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22. The effect of the COVID-19 pandemic on influenza-related hospitalization, intensive care admission and mortality in children in Canada: A population-based study

Author

Bancej, Christina, Burton, Catherine, Embree, Joanne, Foo, Cheryl, Bridger, Natalie, Morris, Robert, Jadavji, Taj, Lebel, Marc, Le Saux, Nicole, Top, Karina A., Tan, Ben, McConnell, Athena, Purewal, Rupeena, Déry, Pierre, Thibeault, Roseline, Vaudry, Wendy, Tran, Dat, Sauvé, Laura, Moore, Dorothy L., Lefebvre, Marie-Astrid, Groves, Helen E., Papenburg, Jesse, Mehta, Kayur, Bettinger, Julie A., Sadarangani, Manish, Halperin, Scott A., and Morris, Shaun K.

Published
2022
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23. Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study

Author

Merckx, Joanna, Cooke, Suzette, Tal, Tala El, Bitnun, Ari, Morris, Shaun K., Yeh, E. Ann, Yea, Carmen, Gill, Peter, Papenburg, Jesse, Lefebvre, Marie-Astrid, Scuccimarri, Rosie, Ulloa-Gutierrez, Rolando, Brenes-Chacon, Helena, Yock-Corrales, Adriana, Ivankovich-Escoto, Gabriela, Soriano-Fallas, Alejandra, Mezerville, Marcela Hernandez-de, Dewan, Tammie, Restivo, Lea, Nateghian, Alireza, Aski, Behzad Haghighi, Manafi, Ali, Dwilow, Rachel, Bullard, Jared, Lopez, Alison, Sadarangani, Manish, Roberts, Ashley, Barton, Michelle, Petel, Dara, Le Saux, Nicole, Bowes, Jennifer, Purewal, Rupeena, Lautermilch, Janell, Tehseen, Sarah, Bayliss, Ann, Wong, Jacqueline K., Leifso, Kirk, Foo, Cheryl, and Robinson, Joan

Subjects
Hospital care -- Statistics, Pediatric research, Health
Abstract

Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit (ICU) and explored changes in disease severity over time. Methods: We obtained data from chart reviews of children younger than 18 years with confirmed or probable MIS-C who were admitted to 15 hospitals in Canada, Iran and Costa Rica between Mar. 1, 2020, and Mar. 7, 2021. Using multivariable analyses, we evaluated whether admission date and other characteristics were associated with ICU admission or cardiac involvement. Results: Of 232 children with MIS-C (median age 5.8 yr), 130 (56.0%) were male and 50 (21.6%) had comorbidities. Seventy-three (31.5%) patients were admitted to the ICU but none died. We observed an increased risk of ICU admission among children aged 13-17 years (adjusted risk difference 27.7%, 95% confidence interval [CI] 8.3% to 47.2%), those aged 6-12 years (adjusted risk difference 25.2%, 95% CI 13.6% to 36.9%) or those with initial ferritin levels greater than 500 [micro]g/L (adjusted risk difference 18.4%, 95% CI 5.6% to 31.3%). Children admitted to hospital after Oct. 31, 2020, had numerically higher rates of ICU admission (adjusted risk difference 12.3%, 95% CI -0.3% to 25.0%) and significantly higher rates of cardiac involvement (adjusted risk difference 30.9%, 95% CI 17.3% to 44.4%). At Canadian sites, the risk of ICU admission was significantly higher for children admitted to hospital between December 2020 and March 2021 than those admitted between March and May 2020 (adjusted risk difference 25.3%, 95% CI 6.5% to 44.0%). Interpretation: We observed that age and higher ferritin levels were associated with more severe MIS-C. We observed greater severity of MIS-C later in the study period. Whether emerging SARS-CoV-2 variants pose different risks of severe MIS-C needs to be determined., Multisystem inflammatory syndrome in children (MIS-C) (1) manifests as immune dysregulation after SARS-CoV-2 infection. (2) The syndrome has no pathognomonic features. Thus, the diagnostic criteria of the Royal College of [...]

Published
2022
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25. Association of maternal, obstetric, fetal, and neonatal mortality outcomes with Lady Health Worker coverage from a cross-sectional survey of >10,000 households in Gilgit-Baltistan, Pakistan

Author

Farrar, Daniel S., primary, Pell, Lisa G., additional, Muhammad, Yasin, additional, Khan, Sher Hafiz, additional, Tanner, Zachary, additional, Bassani, Diego G., additional, Ahmed, Imran, additional, Karim, Muhammad, additional, Madhani, Falak, additional, Paracha, Shariq, additional, Khan, Masood Ali, additional, Soofi, Sajid B., additional, Taljaard, Monica, additional, Spitzer, Rachel F., additional, Abu Fadaleh, Sarah M., additional, Bhutta, Zulfiqar A., additional, and Morris, Shaun K., additional

Published
2024
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28. Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series

Author

Thorburn, Kentigern, Nunes, Marta, Chawana, Richard, Madhi, Shabir A., Vittuci, Anna C., Bassat, Quique, Bardají, Azucena, Goka, Edward, Roglić, Srđan, Paes, Bosco, Elliott, LouAnn, Oshitani, Hitoshi, Lupisan, Socorro, Gentile, Angela, Lucion, María Florencia, Spaeder, Michael C., Butt, Warwick, Thompson, Jenny, Mejias, Asuncion, Ramilo, Octavio, Fasce, Rodrigo A., Werner, Marta, Hijano, Diego R., Allison, Kim J., Pires, Márcia Rosane, de-Paris, Fernanda, Chakhunashvili, Giorgi, Karseladze, Irakli, Otieno, Grieven P., Nokes, D. James, Scheuerman, Oded, Prais, Dario, Amad, Mohammed Al, Serouri, Abdul Wahed Al, Ali, Asad, Yousafzai, Mohammad Tahir, Bruno, Alfredo, de Mora, Domenica, Ojeda, Jenny, Dbaibo, Ghassan, Hanna-Wakim, Rima, Papaevangelou, Vassiliki, Kartisouni, Elpiniki, Cohen, Cheryl, Walaza, Sibongile, Linssen, Rosalie S., Chi, Hsin, Eşki, Aykut, Demir, Esen, Saha, Senjuti, Saha, Samir K, Sochet, Anthony A., Teppa-Sanchez, Beatriz E., Ravindranath, Thyyar M., Baird, J. Scott, Morris, Shaun K., Wong, Waison, Breiman, Robert F., Gurley, Emily S., Arifeen, Shams El, Assefa, Nega, Scott, J. Anthony G., Onyango, Dickens, Kotloff, Karen L., Sow, Samba O., Mandomando, Inacio, Ogbuanu, Ikechukwu U., Jambai, Amara, Kendirli, Tanil, Botan, Edin, Rubio, Franco Díaz, Serra, Alberto, Martinez, Luis, Pedroso, Luis, Menta, Soledad, Pardo, Rosalba, Donoso, Alejandro, Mahmood, Syed Faisal, Khan, Naveera, Löwensteyn, Yvette N, Nair, Harish, Nunes, Marta C, van Roessel, Ichelle, Vernooij, Femke S, Willemsen, Joukje, Bont, Louis J, and Mazur, Natalie I

Published
2021
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29. Could COVID-19 Reverse the Modest Gains Made in Newborn Health in Ethiopia?

Author

Estifanos, Abiy Seifu, Kazmi, Kescha, and Morris, Shaun K.

Subjects
Epidemics -- Control -- Influence -- Ethiopia, Health care reform, Infant health services -- Management, Pediatric research, Company business management, Health care industry
Abstract

Introduction Ethiopia has made remarkable progress in reducing childhood and neonatal mortality in the last two decades. However, with the spread of the COVID-19 pandemic in Ethiopia, disruptions in routine health care pose a significant risk in reversing the gains made in neonatal mortality reduction. Methods Using the World Health Organization's health systems building blocks framework we examined the mechanisms by which the pandemic may impact neonatal health. Results Our analysis suggests that the COVID-19 pandemic and measures taken by the government to control its spread could indirectly set back the gains made in neonatal mortality reduction in Ethiopia by weakening the health system building blocks. On the other hand, by exposing longstanding issues in the health system, the pandemic has pressed health sector stakeholders to urgently test innovative approaches to maintain delivery of essential health care. Conclusions We recommend that the Ministry of Health of Ethiopia strike a right balance between the control of the pandemic and ensuring provision of essential neonatal health services. As the pandemic continues to spread in the country, the government should avoid verticalization of pandemic response efforts and adopt a diagonal investment approach to effectively respond to the pandemic as well as build health system resilience to maintain the gains made in the neonatal health., Author(s): Abiy Seifu Estifanos [sup.1] , Kescha Kazmi [sup.2] , Shaun K. Morris [sup.2] [sup.3] Author Affiliations: (1) grid.7123.7, 0000 0001 1250 5688, Department of Reproductive, Family and Population Health, [...]

Published
2021
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30. Caracteristiques des hospitalisations au Canada d'enfants ayant contracte une infection aigue par le SRAS-CoV-2 en 2020

Author

Drouin, Olivier, Hepburn, Charlotte Moore, Farrar, Daniel S., Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin, Melanie, Luu, Thuy Mai, Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Top, Karina A., Viel-Theriault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Subjects
Infection, Health
Abstract

Contexte : Les facteurs de risque de complications graves de l'infection par le SRAS-CoV-2 n'ont pas ete bien etablis chez les enfants. Nous avons voulu decrire les hospitalisations pediatriques associees au SRAS-CoV-2 au Canada et identifier les facteurs de risque de maladie grave. Methodes : Nous avons procede a une etude prospective nationale en utilisant l'infrastructure du Programme canadien de surveillance pediatrique (PCSP). Les hospitalisations d'enfants ayant contracte une infection par le SRAS-CoV-2 confirmee en laboratoire de microbiologie ont ete rapportees du 8 avril au 31 decembre 2020 au moyen de questionnaires hebdomadaires en ligne distribues au reseau du PCSP, qui compte plus de 2800 pediatres. Nous avons categorise les hospitalisations comme suit : liees a la COVID-19, infections decouvertes fortuitement, ou hospitalisations pour des raisons sociales ou de controle des infections, et degage les facteurs de risque associes a la gravite de la maladie chez les patients hospitalises. Resultats : Sur les 264 hospitalisations d'enfants ayant contracte le SRAS-CoV-2 au cours de la periode de l'etude de 9 mois, 150 (56,8 %) ont ete associees a la COVID-19 et 100 (37,9 %o) etaient des cas decouverts fortuitement (admission pour d'autres raisons et decouverte fortuite du SRAS-CoV-2 par depistage positif). Les nourrissons (37,3 %) et les adolescents (29,6 %) representaient la majorite des cas. Parmi les hospitalisations liees a la COVID-19, 52 patients (34,7 %) etaient atteints d'une forme grave de la mala die, dont 42 (28,0 % des cas lies a la COVID-19) ont eu besoin d'une forme d'assistance respiratoire ou hemodynamique, et 59 (39,3 %o) presentaient au moins 1 comorbidite sous-jacente. Les enfants atteints d'obesite, de maladies neurologiques chroniques ou de maladies pulmonaires chroniques, a l'exclusion de l'asthme, etaient plus susceptibles de presenter une forme grave ou critique de la COVID-19. Interpretation : Parmi les enfants hospitalises au Canada chez lesquels on a diagnostique une infection par le SRAS-CoV-2 au debut de la pandemie de COVID-19, la decouverte fortuite du SRAS-CoV-2 a ete frequente. Chez les enfants hospitalises pour une COVID-19 aigue, l'obesite et les comorbidites neurologiques et respiratoires ont ete associees a une gravite accrue., En date du 31 decembre 2020, le Canada comptait 581 427 cas confirmes d'infection par le SRAS-CoV-2 (1). Comme dans d'autres pays, la plupart des infections confirmees ont ete diagnostiquees [...]

Published
2021
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32. Characteristics of children admitted to hospital with acute SARS-CoV-2 infection in Canada in 2020

Author

Drouin, Olivier, Hepburn, Charlotte Moore, Farrar, Daniel S., Baerg, Krista, Chan, Kevin, Cyr, Claude, Donner, Elizabeth J., Embree, Joanne E., Farrell, Catherine, Forgie, Sarah, Giroux, Ryan, Kang, Kristopher T., King, Melanie, Laffin, Melanie, Luu, Thuy Mai, Orkin, Julia, Papenburg, Jesse, Pound, Catherine M., Price, Victoria E., Purewal, Rupeena, Sadarangani, Manish, Salvadori, Marina I., Top, Karina A., Viel-Theriault, Isabelle, Kakkar, Fatima, and Morris, Shaun K.

Subjects
Children -- Diseases, Pediatric research -- 2020 AD, Hospital patients -- Statistics -- Demographic aspects -- 2020 AD, Health
Abstract

Background: Risk factors for severe outcomes of SARS-CoV-2 infection are not well established in children. We sought to describe pediatric hospital admissions associated with SARS-CoV-2 infection in Canada and identify risk factors for more severe disease. Methods: We conducted a national prospective study using the infrastructure of the Canadian Paediatric Surveillance Program (CPSP). Cases involving children who were admitted to hospital with microbiologically confirmed SARS-CoV-2 infection were reported from Apr. 8 to Dec. 31 2020, through weekly online questionnaires distributed to the CPSP network of more than 2800 pediatricians. We categorized hospital admissions as related to COVID-19, incidental, or for social or infection control reasons and determined risk factors for disease severity in hospital. Results: Among 264 hospital admissions involving children with SARS-CoV-2 infection during the 9-month study period, 150 (56.8%) admissions were related to COVID-19 and 100 (37.9%) were incidental infections (admissions for other reasons and found to be positive for SARS-CoV-2 on screening). Infants (37.3%) and adolescents (29.6%) represented most cases. Among hospital admissions related to COVID-19, 52 (34.7%) had critical disease, 42 (28.0%) of whom required any form of respiratory or hemodynamic support, and 59 (39.3%) had at least 1 underlying comorbidity. Children with obesity, chronic neurologic conditions or chronic lung disease other than asthma were more likely to have severe or critical COVID-19. Interpretation: Among children who were admitted to hospital with SARS-CoV-2 infection in Canada during the early COVID-19 pandemic period, incidental SARS-CoV-2 infection was common. In children admitted with acute COVID-19, obesity and neurologic and respiratory comorbidities were associated with more severe disease., As of Dec. 31, 2020, Canada had 581427 confirmed cases of SARS-CoV-2 infection. (1) Similar to other countries, most confirmed infections were in adults, in part because of initial testing [...]

Published
2021
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33. Clinical Presentations and Outcomes of Children in Canada With Recurrent Invasive Pneumococcal Disease From the IMPACT Surveillance Network

Author

Murad, Yousif, Hung, Te-Yu, Sadarangani, Manish, Morris, Shaun K., Le Saux, Nicole, Vanderkooi, Otto G., Kellner, James D., Tyrrell, Gregory J., Martin, Irene, Demczuk, Walter, Halperin, Scott A., Bettinger, Julie A., Bridger, N., Foo, Cheryl, Halperin, S.A., Top, K.A., Thibeault, R., Moore, D., Papenburg, J., Lebel, M., Le Saux, N., Morris, S., Embree, J., Tan, B., McConnell, Athena, Jadavji, T., Constantinescu, C., Vaudry, W., Scheifele, D., Sadarangani, M., Bettinger, J., and Sauvé, L.

Published
2022
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34. Ethical and cultural implications for conducting verbal autopsies in South and Southeast Asia: a qualitative study

Author

Htun, Nan Shwe Nwe, primary, Perrone, Carlo, additional, Phyo, Aung Pyae, additional, Sen, Aninda, additional, Phommasone, Koukeo, additional, Vanna, Moul, additional, Kanthawang, Nipaphan, additional, Sappayabanphot, Jarntrah, additional, Yotyingaphiram, Widi, additional, Wirachonphaophong, Jindaporn, additional, Kabir, Nawrin, additional, Ol, Sam, additional, Xaiyaphet, Xaipasong, additional, Soulivong, Ailatda, additional, Seevanhthong, Khambang, additional, Tripura, Rupam, additional, Chew, Rusheng, additional, Khirikoekkong, Napat, additional, Morris, Shaun K, additional, Osterrieder, Anne, additional, Cheah, Phaik Yeong, additional, Jha, Prabhat, additional, Lubell, Yoel, additional, and Peto, Thomas J, additional

Published
2023
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38. Infection congenitale probable au SRAS-CoV-2 chez le nouveau-ne d'une femme atteinte de COVID-19 active

Author

Kirtsman, Maksim, Diambomba, Yenge, Poutanen, Susan M., Malinowski, Ann K., Vlachodimitropoulou, Evangelia, Parks, W. Tony, Erdman, Laura, Morris, Shaun K., and Shah, Prakesh S.

Subjects
Coronavirus infections -- Physiological aspects, Fetal diseases -- Research, Infection -- Physiological aspects, COVID-19, Prenatal influences -- Research, Health
Abstract

Une femme de 40 ans (gravida 2, para 1) a ete admise dans un hopital de soins tertiaires de Toronto, en Ontario. On a note chez elle : neutropenie familiale, [...]

Published
2020
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40. Immunological effects and safety of live rotavirus vaccination after antenatal exposure to immunomodulatory biologic agents: a prospective cohort study from the Canadian Immunization Research Network

Author

Fitzpatrick, Tiffany, primary, Alsager, Khaled, additional, Sadarangani, Manish, additional, Pham-Huy, Anne, additional, Murguía-Favela, Luis, additional, Morris, Shaun K, additional, Seow, Cynthia H, additional, Piché-Renaud, Pierre-Philippe, additional, Jadavji, Tajdin, additional, Vanderkooi, Otto G, additional, Top, Karina A, additional, Constantinescu, Cora, additional, Cowan, Juthaporn, additional, Comeau, Jeannette, additional, Derfalvi, Beata, additional, Halperin, Scott A, additional, Burton, Catherine, additional, Suresh, Sneha, additional, Vaudry, Wendy, additional, Finlay, Jane, additional, and Dharmani, Poonam, additional

Published
2023
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41. An integrated newborn care kit (iNCK) to save newborn lives and improve health outcomes in Gilgit Baltistan (GB), Pakistan: study protocol for a cluster randomized controlled trial

Author

Fadaleh, Sarah Abu, primary, Pell, Lisa G., additional, Yasin, Muhammad, additional, Farrar, Daniel S., additional, Khan, Sher Hafiz, additional, Tanner, Zachary, additional, Paracha, Shariq, additional, Madhani, Falak, additional, Bassani, Diego G., additional, Ahmed, Imran, additional, Soofi, Sajid B., additional, Taljaard, Monica, additional, Spitzer, Rachel F., additional, Bhutta, Zulfiqar A., additional, and Morris, Shaun K., additional

Published
2023
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44. Outcomes of immunocompromised children hospitalized for Influenza, 2010-2021, the Canadian Immunization Monitoring Program Active (IMPACT)

Author

Schober, Tilmann, primary, Morris, Shaun K., additional, Bettinger, Julie A., additional, Bancej, Christina, additional, Burton, Catherine, additional, Foo, Cheryl, additional, Halperin, Scott A., additional, Jadavji, Taj, additional, Kazmi, Kescha, additional, Modler, Jacqueline, additional, Sadarangani, Manish, additional, Papenburg, Jesse, additional, Bridger, Natalie, additional, Top, Karina, additional, Thibeault, Roseline, additional, Lebel, Marc, additional, Le Saux, Nicole, additional, Bullard, Jared, additional, Purewal, Rupeena, additional, and Sauvé, Laura, additional

Published
2023
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45. Behavioural Science-Informed Strategies for Increasing COVID-19 Vaccine Uptake in Children and Youth

Author

Shapiro, Gilla K., primary, Presseau, Justin, additional, Weerasinghe, Ashini, additional, Allen, Upton, additional, Arnason, Trevor, additional, Bodmer, Nicolas. S, additional, Born, Karen B., additional, Buchan, Judy L., additional, Burns, Rachel, additional, Corace, Kimberly M., additional, Dubey, Vinita, additional, Evans, Gerald A., additional, Fabrigar, Leandre R., additional, Grimshaw, Jeremy M., additional, Maguire, Jonathon L., additional, Manuel, Douglas G., additional, Morris, Shaun K., additional, Mosher, Rhiannon, additional, Orkin, Julia, additional, Perkhun, Anna, additional, Piche-Renaud, Pierre-Philippe, additional, Schwartz, Brian, additional, Science, Michelle, additional, Sivadas, Shuruthisai, additional, Wilson, Sarah E., additional, and Desveaux, Laura, additional

Published
2021
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46. Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection

Author

Kirtsman, Maksim, Diambomba, Yenge, Poutanen, Susan M., Malinowski, Ann K., Vlachodimitropoulou, Evangelia, Parks, W. Tony, Erdman, Laura, Morris, Shaun K., and Shah, Prakesh S.

Subjects
EPUB (Standard), Bacterial infections, Severe acute respiratory syndrome, Coronaviruses, Newborn infants, COVID-19, Health
Abstract

A 40-year-old woman (gravida 2, para 1) was admitted to a tertiary hospital in Toronto, Ontario. She had familial neutropenia, gestational diabetes and a history of frequent bacterial infections, including [...]

Published
2020
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48. Changes in cause-specific neonatal and 1–59-month child mortality in India from 2000 to 2015: a nationally representative survey

Author

Fadel, Shaza A, Rasaily, Reeta, Awasthi, Shally, Begum, Rehana, Black, Robert E, Gelband, Hellen, Gerland, Patrick, Kumar, Rajesh, Liu, Li, Mathers, Colin, Morris, Shaun K, Nair, Saritha, Newcombe, Leslie, Pandey, Arvind, Ram, Faujdar, Ram, Usha, Rodriguez, Peter S, Sahu, Damodar, Sati, Prabha, Shah, Prakash J, Shet, Anita, Sheth, Jay, Singh, Jitenkumar K, Singh, Lucky, Sinha, Anju, Suraweera, Wilson, and Jha, Prabhat

Published
2017
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