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2. Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease.

Author

Braescu, Laurentiu, Sturza, Adrian, Sosdean, Raluca, Aburel, Oana Maria, Lazar, Mihai Andrei, Muntean, Danina, Luca, Constantin Tudor, Brie, Daniel Miron, Feier, Horea, Crisan, Simina, and Mornos, Cristian

Subjects
EPICARDIAL adipose tissue, CORONARY artery disease, CARDIAC surgery, CARDIOVASCULAR diseases risk factors, REACTIVE oxygen species
Abstract

This study aimed to assess the utility of echocardiography-measured epicardial adipose tissue (EAT) thickness (EATT) as an independent predictor for coronary artery disease (CAD), examining its correlation with oxidative stress levels in epicardial tissue and the complexity of the disease in patients undergoing open-heart surgery. This study included a total of 25 patients referred for cardiac surgery with 14 in the CAD group and 11 in the non-CAD group. Epicardial fat was sampled from patients subjected to open-heart surgery. EATT was higher in the CAD group compared to the non-CAD group (8.15 ± 2.09 mm vs. 5.12 ± 1.8 mm, p = 0.001). The epicardial reactive oxygen species level was higher in the CAD group compared to the non-CAD group (21.4 ± 2.47 nmol H2O2/g tisssue/h vs. 15.7 ± 1.55 nmol H2O2/g tisssue/h, p < 0.001). EATT greater than 6.05 mm was associated with CAD, with a sensitivity of 86% and specificity of 73%. Echocardiographically measured EATT is a significant, independent predictor of CAD. Its relationship with increased EAT oxidative stress levels suggests a potential mechanistic link between EATT and CAD pathogenesis. These findings highlight the importance of EATT as a diagnostic tool in assessing the complexity of CAD in patients undergoing cardiac surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Contemporary Management of Severe Symptomatic Aortic Stenosis

Author

Iung, Bernard, Bax, Jeroen, De Bonis, Michele, Delgado, Victoria, Haude, Michael, Hindricks, Gerhard, Maggioni, Aldo P., Pierard, Luc, Popescu, Bogdan A., Prendergast, Bernard, Price, Susanna, Rosenhek, Raphael, Ruschitzka, Frank, Vahanian, Alec, Wendler, Olaf, Windecker, Stephan, Mekhaldi, Souad, Lemaitre, Katell, Authier, Sébastien, Laroche, Cécile, Abdelhamid, Magdy, Apor, Astrid, Bajraktari, Gani, Beleslin, Branko, Bogachev-Prokophiev, Alexander, Demarco, Daniela Cassar, Pasquet, Agnes, Dogan, Sait Mesut, Erglis, Andrejs, Evangelista, Arturo, Goda, Artan, Ihlemann, Nikolaj, Ince, Huseyin, Katsaros, Andreas, Linhartova, Katerina, Mascherbauer, Julia, Mirrakhimov, Erkin, Mizariene, Vaida, Rahman-Haley, Shelley, Ribeiras, Regina, Samadov, Fuad, Saraste, Antti, Simkova, Iveta, Kostovska, Elizabeta Srbinovska, Tomkiewicz-Pajak, Lidia, Tribouilloy, Christophe, Zera, Eliverta, Metalla, Mimoza, Shirka, Ervina, Dado, Elona, Bica, Loreta, Aleksi, Jorida, Knuti, Gerti, Gjyli, Lidra, Pjeci, Rudina, Shuperka, Eritinka, Lleshi, Erviola, Rustemaj, Joana, Qordja, Marsjon, Gina, Mirald, Husi, Senada, Basic, Daniel, Steringer-Mascherbauer, Regina, Huber, Charlotte, Ebner, Christian, Sigmund, Elisabeth, Ploechl, Andrea, Sturmberger, Thomas, Eder, Veronica, Koppler, Tanja, Heger, Maria, Kammerlander, Andreas, Duca, Franz, Binder, Christina, Koschutnik, Matthias, Perschy, Leonard, Puskas, Lisa, Ho, Chen-Yu, Aliyev, Farid, Guluzada, Vugar, Imanov, Galib, Ibrahimov, Firdovsi, Abbasaliyev, Abbasali, Ahmedov, Tahir, Muslumova, Fargana, Babayev, Jamil, Rustamova, Yasmin, Jahangirov, Tofig, Samadov, Rauf, Museyibov, Muxtar, Isayev, Elnur, Musayev, Oktay, Xalilov, Shahin, Huseynov, Saleh, Yuzbashova, Madina, Zamanov, Vuqar, Mammadov, Vusal, Van Camp, Gery, Penicka, Martin, Batjoens, Hedwig, Debonnaire, Philippe, Dendooven, Daniel, Knecht, Sebastien, Duytschaever, Mattias, Vandekerckhove, Yves, Missault, Luc, Muyldermans, Luc, Tavernier, René, De Grande, Tineke, Coussement, Patrick, DeTroyer, Joyce, Derycker, Katrien, De Jaegher, Kelly, Bondue, Antoine, Beauloye, Christophe, Goffinet, Céline, Mirica, Daniela Corina, Eynden, Frédéric Vanden, Van de Borne, Philippe, Van Frachen, Béatrice, Vancraeynest, David, Vanoverschelde, Jean Louis, Pierard, Sophie, Malanca, Mihaela, Sinnaeve, Florence, Tahon, Séverine, De Clippel, Marie, Gayet, Frederic, Loiseau, Jacques, Van de Veire, Nico, Moerman, Veronique, Willems, Anne-Marie, Cosyns, Bernard, Droogmans, Steven, Motoc, Andreea, Kerkhove, Dirk, Plein, Daniele, Roosens, Bram, Weytjens, Caroline, Lancellotti, Patrizio, Dulgheru, Elena Raluca, Parenicova, Ilona, Bedanova, Helena, Tousek, Frantisek, Sindelarova, Stepanka, Canadyova, Julia, Taborsky, Milos, Ostransky, Jiri, Ivona simkova, Vicha, Marek, Jelinek, Libor, Opavska, Irena, Homza, Miroslav, Kvrayola, Miriam, Brat, Radim, Mrozek, Dan, Lichnerova, Eva, Docekalova, Iveta, Zarybnicka, Marta, Peskova, Marketa, Roucka, Patrik, Stastna, Vlasta, Vondrackova, Dagmar Jungwirtova, Hornig, Alfred, Niznansky, Matus, Branny, Marian, Vodzinska, Alexandra, Dorda, Miloslav, Snkouril, Libor, Kluz, Krystyna, Kypusova, Jana, Nezvalova, Radka, Olsen, Niels Thue, Ali, Hosam Hasan, Taha, Salma, Hassan, Mohamed, Afifi, Ahmed, Kabil, Hamza, Mady, Amr, Ebaid, Hany, Ahmed, Yasser, Nour, Mohammad, Talaat, Islam, Sayed, CairoMaiy El, Mostafa, Ahmad Elsayed, Sadek, CairoYasser, Eltobgi, CairoSherif, Bakhoum, Sameh, Doss, Ramy, Sheashea, Mahmoud, Elasry, Abd Allah, Fouad, Ahmed, Baraka, Mahmoud, Samir, Sameh, Roshdy, Alaa, AbdelRazek, Yasmin, Abd Rabou, Mostafa M., Abobakr, Ahmed, Moaaz, Moemen, Mokhtar, Mohamed, Ashry, Mohamed, Elkhashab, Khaled, Ghareeb, Haytham Soliman, Kamal, Mostafa, AbdelRazek, Gomaa, Farag, GizaNabil, Elbarbary, Giza:Ahmed, Wahib, Evette, Kazamel, Ghada, Kamal, Diaa, Tantawy, Mahmoud, Alansary, Adel, Yahia, Mohammed, Mahmoud, Raouf, El Banna, Tamer, Atef, Mohamed, Nasr, Gamela, Ahmed, Salah, El Hefny, Ehab E., Saifelyazal, Islam, El Ghany, Mostafa Abd, El Rahman El Hadary, Abd, Khairy, Ahmed, Lommi, Jyri, Laine, Mika, Kylmala, Minna, Kankanen, Katja, Turpeinen, Anu, Hartikainen, Juha, Kujanen, Lari, Airaksinen, Juhani, Vasankari, Tuija, Szymanski, Catherine, Bohbot, Yohann, Gun, Mesut, Rousseaux, Justine, Biere, Loic, Mateus, Victor, Audonnet, Martin, Rautureau, Jérémy, Cornet, Charles, Sorbets, Emmanuel, Mear, BourgesKarine, Issa, Adi, Jobic, Yannick, Le Ven, Florent, Pouliquen, Marie-Claire, Gilard, Martine, Ohanessian, Alice, Farhat, Ali, Vlase, Alina, Said, Fkhar, Lasgi, Caroline, Sanchez, Carlos, Breil, Romain, Peignon, Marc, Elkaim, Jean-Philippe, Jan-Blin, Virginie, BertrandM'Ban, Sylvain Ropars, Bardet, Hélène, Sawadogo, Samuel, Muschoot, Aurélie, Tchatchoua, Dieudonné, Elhadad, Simon, Maubert, Aline, Lazizi, Tahar, Ourghi, Kais, Bonnet, Philippe, Menager-Gangloff, Clarisse, Gafsi, Sofiene, Mansouri, Djidjiga, Aboyans, Victor, Magne, Julien, Martins, Elie, Karm, Sarah, Mohty, Dania, Briday, Guillaume, David, 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Alexander, Lortz, Julia, Lüdike, Peter, Kahlert, Philipp, Rittger, Harald, Eichinger, Gabriele, Kuhls, Britta, Felix, Stephan B., Lehnert, Kristin, Pedersen, Ann-Louise, Dorr, Marcus, Empen, Klaus, Kaczmarek, Sabine, Busch, Mathias, Baly, Mohammed, Er, Fikret, Duman, Erkan, Gabriel, Linda, Weinbrenner, Christof, Bauersachs, Johann, Wider, Julian, Kempf, Tibor, Bohm, Michael, Schulze, Paul-Christian, Poerner, C. Tudor, Möbius-Winkler, Sven, Lenk, Karsten, Heitkamp, Kerstin, Franz, Marcus, Krauspe, Sabine, Schumacher, Burghard, Windmuller, Volker, Kurwitz, Sarah, Thiele, Holger, Kurz, Thomas, Meyer-Saraei, Roza, Akin, Ibrahim, Fastner, Christian, Lossnitzer, Dirk, Hoffmann, Ursula, Borggrefe, Martin, Baumann, Stefan, Kircher, Brigitte, Foellinger, Claudia, Dietz, Heike, Schieffer, Bernhard, Niroomand, Feraydoon, Mudra, Harald, Maier, Lars, Camboni, Daniele, Birner, Christoph, Debl, Kurt, Paulus, Michael, Seither, Benedikt, El Mokhtari, Nour Eddine, Oner, Alper, Caglayan, Evren, Sherif, Mohammed, Yucel, Seyrani, Custodis, Florian, Schwinger, Robert, Vorpahl, Marc, Seyfarth, Melchior, Nover, Ina, Koehler, Till, Christiani, Sarah, Sanchez, David Calvo, Schanze, Barbel, Sigusch, Holger, Salman, Athir, Hancock, Jane, Chambers, John, Demetrescue, Camelia, Prendergast, Claire, Dalby, Miles, Smith, Robert, Rogers, Paula, Riley, Cheryl, Tousoulis, Dimitris, Kanakakis, Ioannis, Spargias, Konstantinos, Lampropoulos, Konstantinos, Panagiotis, Tolis, Koutsoukis, Athanasios, Michalis, Lampros, Goudevenos, Ioannis, Bellos, Vasileios, Papafaklis, Michail, Lakkas, Lampros, Hahalis, George, Makris, Athanasios, Karvounis, Haralampos, Kamperidis, Vasileios, Ninios, Vlasis, Sachpekidis, Vasileios, Rouskas, Pavlos, Poulimenos, Leonidas, Charalampidis, Georgios, Hamodraka, Eftihia, Manolis, Athanasios, Kiss, Robert Gabor, Borsanyi, Tunde, Jarai, Zoltan, Zsary, Andras, Bartha, Elektra, Kosztin, Annamaria, Doronina, Alexandra, Kovacs, Attila, Imre, Barabas Janos, Chao, Chun, Benke, Kalman, Karoczkai, Istvan, Keltai, Kati, Förchécz, Zsolt, Pozsonyi, Zoltán, Jenei, Zsigmond, Patthy, Adam, Sallai, Laszlo, Majoros, Zsuzsanna, Pál, Tamás, Bencze, Jusztina, Sagi, Ildiko, Molnar, Andrea, Kurczina, Anita, Kolodzey, Gabor, Edes, Istvan, Szatmari, Valeria, Zajacz, Zsuzsanna, Cziraki, Attila, Nemeth, Adam, Faludi, Reka, Vegh, Laszlone, Jebelovszki, Eva, Lupkovics, Geza Karoly, Kovacs, Zsofia, Horvath, Andras, Berisha, Gezim, Ibrahimi, Pranvera, Percuku, Luan, Arapova, Rano, Laahunova, Elmira, Neronova, Kseniia, Zhakypova, Zarema, Naizabekova, Gulira, Muratova, Gulnazik, Sime, Iveta, Sorokins, Nikolajs, Kamzola, Ginta, Cgojeva-Sproge, Irina, Rancane, Gita, Valentinaviciene, Ramune, Rudiene, Laima, Raugaliene, Rasa, Bardzilauske, Aiste, Jonkaitiene, Regina, Petrauskaite, Jurate, Bieseviciene, Monika, Verseckaite, Raimonda, Zvirblyte, Ruta, Kalibatiene, Danute, Radauskaite, Greta, Janaviciute-Matuzeviciene, Gabija, Jancauskaite, Dovile, Balkute, Deimile, Maneikyte, Juste, Mileryte, Ingrida, Vaisvilaite, Monika, Gedvilaite, Lina, Biliukas, Mykolas, Karpaviciene, Vaiva, Xuereb, Robert George, Pllaha, Elton, Djaberi, Roxana, Komor, Klaudiusz, Gorgon-Komor, Agnieszka, Loranc, Beata, Myszor, Jaroslaw, Mizia-Stec, Katarzyna, Berger-Kucza, Adrianna, Mizia, Magdalena, Polak, Mateusz, Bogacki, Piotr, Podolec, Piotr, Komar, Monika, Sedziwy, Ewa, Sliwiak, Dorota, Sobien, Bartosz, Rog, Beata, 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Inocencia, Oliveira, Margarida, Calvo, Lucy, von Hate, Pedro, Faria, Bebiana, Galrinho, Ana, Branco, Luisa, Goncalves, Antonio, Mendonca, Tiago, Selas, Mafalda, Macedo, Filipe, Sousa, Carla, Cabral, Sofia, Oliveira, Filomena, Trepa, Maria, Fontes-Oliveira, Marta, Nunes, Alzira, Araújo, Paulo, Ribeiro, Vasco Gama, Almeida, Joao, Rodrigues, Alberto, Braga, Pedro, Dias, Sonia, Carvalho, Sofia, Ferreira, Catarina, Ferreira, Alberto, Mateus, Pedro, Moz, Miguel, Leao, Silvia, Margato, Renato, Moreira, Ilidio, Guimanaes, Jose, Ribeiro, Joana, Goncalves, Fernando, Cabral, Jose, Almeida, Ines, Goncalves, Luisa, Tarusi, Mariana, Pop, Calin, Matei, Claudia, Tint, Diana, Barbulescu, Sanziana, Micu, Sorin, Pop, Ioana, Baba, Costica, Dimulescu, Doina, Dorobantu, Maria, Ginghina, Carmen, Onut, Roxana, Popescu, Andreea, Zamfirescu, Brandusa, Aflorii, Raluca, Popescu, Mihaela, Ghilencea, Liviu, Rachieru, Andreeea, Stoian, Monica, Oprescu, Nicoleta, Iancovici, Silvia, Petre, Iona, Mateescu, Anca Doina, Calin, Andreea, Botezatu, Simona, Enache, Roxana, Rosca, Monica, Ciuperca, Daniela, Babalac, Evelyn, Beyer, Ruxandra, Cadis, Laura, Rancea, Raluca, Tomoaia, Raluca, Rosianu, Adela, Kovacs, Emese, Militaru, Constantin, Craciun, Alina, Mirea, Oana, Florescu, Mihaela, Grigorica, Lucica, Dragusin, Daniela, Nechita, Luiza, Marinescu, Mihai, Chiscaneanu, Teodor, Botezatu, Lucia, Corciova, Costela, Petris, Antoniu Octavian, Arsenescu-Georgescu, Catalina, Salaru, Delia, Alexandrescu, Dan Mihai, Plesoianu, Carmjen, Tanasa, Ana, Mitu, Ovidiu, Costache, Irina Iuliana, Tudorancea, Ionut, Usurelu, Catalin, Eminovici, Gabriela, Manitiu, Ioan, Stoia, Oana, Mitre, Adriana, Nistor, Dan-Octavian, Maier, Anca, Lupu, Silvia, Opris, Mihaela, Ionac, Adina, Popescu, Irina, Crisan, Simina, Mornos, Cristian, Goanta, Flavia, Gruescu, Liana, Voinescu, Oana, Petcu, Madalina, Cozlac, Ramona, Damrina, Elena, Khilova, Liliya, Ryazantseva, Irina, Kozmin, Dmitry, Kiseleva, Maria, Goncharova, Marina, Kitalaeva, Kamila, Demetskay, Victoria, Verevetinov, Artem, Fomenko, Mikhail, Skripkina, Elena, Tsoi, Viktor, Antipov, Georgii, Schneider, Yuri, Yazikov, Denis, Makarova, Marina, Cherkes, Aleksei, Ermakova, Natalya, Medvedev, Aleksandr, Sarosek, Anastasia, Isayan, Mikhail, Voronova, Tatyana, Kulumbegov, Oleg, Tuchina, Alina, Stefanov, Sergei, Klimova, Margarita, Smolyaninov, Konstantin, Dandarova, Zhargalma, Magamet, Victoriya, Spiropulos, Natalia, Boldyrev, Sergey, Barbukhatty, Kirill, Buyankov, Dmitrii, Yurin, Vladimir, Gross, Yuriy, Boronin, Maksim, Mikhaleva, Mariya, Shablovskaya, Mariya, Zotov, Alex, Borisov, Daniil, Tereshchenko, Vasily, Zubova, Ekaterina, Kuzmin, A., Tarasenko, Ivan, Gamzaev, Alishir, Borovkova, Natalya, Koroleva, Tatyana, Botova, Svetlana, Pochinka, Ilya, Dunaeva, Vera, Teplitskaya, Victoria, Semenova, Elena I., Korabel'Nikova, Olga V., Simonov, Denis S., Denisenko, Elena, Harina, Natalia, Yarohno, Natalia, Alekseeva, Svetlana, Abydenkova, Julia, Shabalkina, Lyubov, Mayorova, Olga, Tsechanovich, Valeriy, Medvedev, Igor, Lepilin, Michail, Nemchenko, PenzaEvgenii, Karnahin, Vadim, Safina, Vasilya, Slastin, Yaroslav, Gilfanova, Venera, Gorbunov, Roman, Jakubov, Ramis, Fazylova, Aigul, Poteev, Mansur, Vazetdinova, Laysan, Tarasova, Indira, Irgaliyev, Rishat, Moiseeva, Olga, Gordeev, Mikhail, Irtyuga, Olga, Moiseeva, Raisa, Ostanina, Nina, Zverev, Dmitry, Murtazalieva, Patimat, Kuznetsov, Dmitry, Skurativa, Mariya, Polyaeva, Larisa, Mihaiilov, Kirill, Obrenovic-Kircanski, Biljana, Putnik, Svetozar, Simic, Dragan, Petrovic, Milan, Nikolic, Natasa Markovic, Jovovic, Ljiljana, Ostric, Dimitra Kalimanovska, Brajovic, Milan, Manojlovic, Milica Dekleva, Novakovic, Vladimir, Zamaklar-Trifunovic, Danijela, Orbovic, Bojana, Petrovic, Olga, Boricic-Kostic, Marija, Andjelkovic, Kristina, Milanov, Marko, Despotovic-Nikolic, Maja, Budisavljevic, Sreten, Veljkovic, Sanja, Cvetinovic, Nataša, Lepojevic, Daniijela, Todorovic, Aleksandra, Nikolic, Aleksandra, Borzanovic, Branislava, Trkulja, Ljiljana, Tomic, Slobodan, Vukovic, Milan, Milosavljevic, Jelica, Milanovic, Mirjana, Stakic, Vladan, Cvetkovic, Aleksandra, Milutinovic, Suzana, Bozic, Olivera, Miladinovic, Miodrag, Nikolic, Zoran, Despotovic, Dinka, Jovanovic, Dimitrije, Stojsic-Milosavljevic, Anastazija, Ilic, Aleksandra, Sladojevic, Mirjana, Susak, Stamenko, Maletin, Srdjan, Pavlovic, Salvo, Kuzmanovic, Vladimir, Ivanovic, Nikola, Dejanovic, Jovana, Ruzicic, Dusan, Drajic, Dragana, Cvetanovic, Danijel, Mirkovic, Marija, Omoran, Jon, Margoczy, Roman, Sedminova, Katarina, Reptova, Adriana, Baranova, Eva, Valkovicova, Tatiana, Valocik, Gabriel, Kurecko, Marian, Vachalcova, Marianna, Kollarova, Alzbeta, Studencan, Martin, Alusik, Daniel, Kozlej, Marek, Macakova, Jana, Moral, Sergio, Cladellas, Merce, Luiso, Daniele, Calvo, Alicia, Palet, Jordi, Carballo, Juli, Tura, Gisela Teixido, Maldonado, Giuliana, Gutierrez, Laura, Gonzalez-Alujas, Teresa, Jose Fernando, Rodriguez Palomares, Villalva, Nicolas, Molina-Mora, Ma Jose, Paton, Ramon Rubio, Martinez Diaz, Juan Jose, Ruiz, Pablo Ramos, Valle, Alfonso, Rodriguez, Ana, Alania, Edgardo, Galcera, Emilio, Seller, Julia, Valenzuela, Gonzalo de la Morena, Espin, Daniel Saura, Garcia, Dolores Espinosa, Oliva Sandoval, Maria Jose, Gonzalez, Josefa, Navarro, Miguel Garcia, Perez-Martinez, Maria Teresa, Ortega Trujillo, Jose Ramon, Gallego, Irene Menduina, San Roman, Daniel, Perez Nogales, Eliu David, Medina, Olga, Montiel Quintero, Rodolfo Antonio, Bujanda Morun, Pablo Felipe, Perez, Marta Lopez, Huaripata, Jimmy Plasencia, Morales Gonzalez, Juan Jose, Nelson, Veronica Quevedo, Zamorano, Jose Luis, Gomez, Ariana Gonzalez, Fraile, Alfonso, Alberca, Maria Teresa, Martin, Joaquin Alonso, Fernandez-Golfin, Covadonga, Ramos, Javier, Jimenez, Sergio Hernandez, Mitroi, Cristina, Sanchez Fernandez, Pedro L., Diaz-Pelaez, Elena, Garde, Beatriz, Caballero, Luis, Garcia, Fermin Martinez, Cambronero, Francisco, Castro, Noelia, Castro, Antonio, De La Rosa, Alejandro, Gallego, Pastora, Mendez, Irene, Villegas, David Villagomez, Correa, Manuel Gonzalez, Calvo, Roman, Florian, Francisco, Paya, Rafael, Esteban, Esther, Buendia, Francisco, Cubillos, Andrés, Fernandez, Carmen, Cárdenas, Juan Pablo, Pérez-Boscá, José Leandro, Vano, Joan, Belchi, Joaquina, Iglesia-Carreno, Cristina, Iglesias, Francisco Calvo, Escudero-Gonzalez, Aida, Zapateria-Lucea, Sergio, Duarte, Juan Sterling, Perez-Davila, Lara, Cobas-Paz, Rafael, Besada-Montenegro, Rosario, Fontao-Romeo, Maribel, Lopez-Rodriguez, Elena, Paredes-Galan, Emilio, Caneiro-Queija, Berenice, Gonzalez, Alba Guitian, Bozkurt, Abdi, Demir, Serafettin, Unlu, Durmus, Cagliyan, Caglar Emre, Ikikardes, Muslum Firat, Tangalay, Mustafa, Kuloglu, Osman, Ozer, Necla, Canpolat, Ugur, Kemaloglu, Melek Didem, Demirtas, Abdullah Orhan, Akgün, Didar Elif, Avci, Eyup, Taylan, Gokay, Yilmaztepe, Mustafa Adem, Ucar, Fatih Mehmet, Altay, Servet, Gurdogan, Muhammet, Gudul, Naile Eris, Aktas, Mujdat, Buyuklu, Mutlu, Degirmenci, Husnu, Turan, Mehmet Salih, Mert, Kadir Ugur, Mert, Gurbet Ozge, Dural, Muhammet, Arslan, Sukru, Sayar, Nurten, Kanar, Batur, Sadic, Beste Ozben, Sahin, Ahmet Anil, Buyuk, Ahmet, Kilicarslan, Onur, Bostan, Cem, Yildirim, Tarik, Yildirim, Seda Elcim, Cosansu, Kahraman, Varim, Perihan, Ilguz, Ersin, Demirbag, Recep, Yesilay, Asuman, Cirit, Abdullah, Tusun, Eyyup, Erkus, Emre, Sayin, Muhammet Rasit, Kazaz, Zeynep, Kul, Selim, Karabag, Turgut, Kalayci, Belma, Eugène, Marc, and Bax, Jeroen J.

Published
2021
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4. Infective Endocarditis in Patients on Chronic Hemodialysis

Author

Clara, Liliana, Sanchez, Marisa, Casabé, José, Cortes, Claudia, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Altclas, Javier, Kogan, Silvia, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Harkness, John, Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, Passos de Brito, Ana Cláudia, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Varejao Strabelli, Tania Mara, Campos Vieira, Marcelo Luiz, de Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, Fortes, Claudio Querido, de Oliveira Ramos, Auristela, Weksler, Clara, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Fernandez, Ricardo, Franco, Liliana, Gonzalez, Javier, Jaramillo, Astrid Natalia, Barsic, Bruno, Bukovski, Suzana, Krajinovic, Vladimir, Pangercic, Ana, Rudez, Igor, Vincelj, Josip, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, El Kholy, Amani, Mishaal, Marwa, Osama, Dina, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, CHU Catherine, Doco-Lecompte, Thanh, Selton-Suty, Christine, Casalta, Jean-Paul, Fournier, Pierre-Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Francois, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Flecher, Erwan, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Chevalier, Florent, Jeu, Antoine, Rémadi, Jean Paul, Rusinaru, Dan, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Christoph, Neuerburg, Carl, Mazaheri, Bahram, Sophia Athanasia, Carl Neuerburg, Deliolanis, Ioannis, Giamarellou, Helen, Thomas, Tsaganos, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Papanikolaou, Konstantinos, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, Vinod, Venugopal, Krishnan, Hannan, Margaret M., Hurley, John P., Wanounou, Maor, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Durante-Mangoni, Emanuele, Iossa, Domenico, Orlando, Serena, Ursi, Maria Paola, Pafundi, Pia Clara, D’Amico, Fabiana, Bernardo, Mariano, Cuccurullo, Susanna, Dialetto, Giovanni, Covino, Franco Enrico, Manduca, Sabrina, Della Corte, Alessandro, De Feo, Marisa, Tripodi, Marie Françoise, Cecchi, Enrico, De Rosa, Francesco, Forno, Davide, Imazio, Massimo, Trinchero, Rita, Grossi, Paolo, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Carosi, Giampiero, Magri, Silvia, Signorini, Liana, Kanafani, Zeina, Kanj, Souha S., Sharif-Yakan, Ahmad, Abidin, Imran, Tamin, Syahidah Syed, Martínez, Eduardo Rivera, Soto Nieto, Gabriel Israel, van der Meer, Jan T.M., Chambers, Stephen, Holland, David, Morris, Arthur, Raymond, Nigel, Read, Kerry, Murdoch, David R., Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O.M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Vinogradova, Tatiana, Edathodu, Jameela, Halim, Magid, Liew, Yee-Yun, Tan, Ru-San, Lejko-Zupanc, Tatjana, Logar, Mateja, Mueller-Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manel, Ambrosioni, Juan, Azqueta, Manuel, Brunet, Merce, Castro, Pedro, De Lazzari, Elisa, Falces, Carlos, Fuster, David, Fita, Guillermina, Garcia- de- la- Maria, Cristina, Garcia-Gonzalez, Javier, Gatell, Jose M., Llopis, Jaume, Marco, Francesc, Miró, José M., Moreno, Asuncion, Ortiz, José, Ninot, Salvador, Paré, J. Carlos, Pericas, Juan M., Quintana, Eduard, Ramirez, Jose, Rovira, Irene, Sandoval, Elena, Sitges, Marta, Tellez, Adrian, Tolosana, José M., Vidal, Barbara, Vila, Jordi, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Bouza, Emilio, Garcia Fernández, Miguel Angel, Gonzalez-Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez-Créixems, Marta, Solis, Jorge, Almirante, Benito, Fernandez-Hidalgo, Nuria, Tornos, Pilar, de Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Olaison, Lars, Snygg-Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Chu, Vivian H., Corey, G. Ralph, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Lalani, Tahaniyat, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Wang, Andrew, Woods, Christopher W., Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Wray, Dannah, Dickerman, Stuart A., Bonilla, Hector, DiPersio, Joseph, Salstrom, Sara-Jane, Baddley, John, Patel, Mukesh, Peterson, Gail, Stancoven, Amy, Levine, Donald, Riddle, Jonathan, Rybak, Michael, Cabell, Christopher H., Pericàs, Juan M., Jiménez-Exposito, Maria Jesús, Kourany, Wissam M., Montagna-Mella, Rodrigo, Mestres, Carlos A., de Lazzari, Elisa, Fowler, Vance G., Jr., and Miró, Jose M.

Published
2021
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6. Assessing the Relationship between Indexed Epicardial Adipose Tissue Thickness, Oxidative Stress in Adipocytes, and Coronary Artery Disease Complexity in Open-Heart Surgery Patients

Author

Braescu, Laurentiu, primary, Sturza, Adrian, additional, Aburel, Oana Maria, additional, Sosdean, Raluca, additional, Muntean, Danina, additional, Luca, Constantin Tudor, additional, Brie, Daniel Miron, additional, Feier, Horea, additional, Crisan, Simina, additional, and Mornos, Cristian, additional

Published
2024
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7. Subtle Changes in Myocardial Work Indices Assessed by 2D-Speckle Tracking Echocardiography Are Linked with Pathological LV Remodeling and MACEs Following an Acute Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention

Author

Arnautu, Diana-Aurora, primary, Gheorghiu, Alexandru, additional, Arnautu, Sergiu-Florin, additional, Tomescu, Mirela-Cleopatra, additional, Malita, Claudiu-Daniel, additional, Banciu, Christian, additional, Vacarescu, Cristina, additional, Ionac, Ioana, additional, Luca, Silvia, additional, Cozma, Dragos, additional, Mornos, Cristian, additional, Gaita, Dan, additional, and Luca, Constantin-Tudor, additional

Published
2023
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8. Reduced Left Ventricular Twist Early after Acute ST-Segment Elevation Myocardial Infarction as a Predictor of Left Ventricular Adverse Remodelling

Author

Lazăr, Mihai-Andrei, primary, Ionac, Ioana, additional, Luca, Constantin-Tudor, additional, Petrescu, Lucian, additional, Vacarescu, Cristina, additional, Crisan, Simina, additional, Gaiță, Dan, additional, Cozma, Dragos, additional, Sosdean, Raluca, additional, Arnăutu, Diana-Aurora, additional, Cozlac, Alina-Ramona, additional, Luca, Slivia-Ana, additional, Gurgu, Andra, additional, Totorean, Claudia, additional, and Mornos, Cristian, additional

Published
2023
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9. Risk stratification in patients with heart failure: the value of considering both global longitudinal left ventricular strain and mechanical dispersion

Author

Mornos, Cristian, Muntean, Danina, Mornos, Aniko, Crisan, Simina, Petrescu, Lucian, Ionac, Adina, Sosdean, Raluca, and Cozma, Dragos

Subjects
Cardiovascular diseases -- Physiological aspects -- Prevention, Heart failure -- Physiological aspects -- Prevention, Biological sciences
Abstract

In previous studies, mechanical dispersion (MD) predicted ventricular arrhythmias independently of left ventricular ejection fraction (LVEF). Moreover, the combination of MD and global longitudinal strain (GLS) increased the prediction of arrhythmic events. We investigated the prognostic value of a new 2-dimensional strain index, GLS/MD, in patients with heart failure (HF). We analyzed 340 consecutive HF outpatients in sinus rhythm. Echocardiography was performed at 1.6 [+ or -] 0.4 months after hospital discharge. The end point included sudden cardiac death, ventricular fibrillation, and sustained ventricular tachycardia (SCD/VA). During the follow-up period (36 [+ or -] 9 months), SCD/VA occurred in 48 patients (14.1%). A multivariate Cox regression analysis, which included LVEF, early diastolic transmitral / mitral annular velocity ratio (E/E'), GLS, MD, and GLS/MD in the model, revealed that GLS/MD was the best independent predictor of SCD/VA (HR = 3.22, 95% confidence interval = 1.72-6.15, p = 0.03). Separate inclusion of LVEF, systolic mitral annular velocity, E/E', GLS, and MD together with GLS/MD showed that GLS/MD remained the best predictor of SCD/VA (each p Key words: heart failure, malignant ventricular arrhythmia, cardiovascular risk stratification, 2D strain imaging, global longitudinal strain, mechanical dispersion, GLS/MD ratio. Dans des etudes anterieures, la dispersion mecanique (DM) etait un facteur predictif des arythmies ventriculaires independant de la fraction d'ejection ventriculaire gauche (FEVG). De plus, l'association de la DM avec le strain longitudinal global (SLG) augmentait la predictibilite des evenements arythmiques. Nous avons etudie la valeur pronostique du ratio SLG/DM, un nouvel indice de strain bidimensionnel, chez des patients atteints d'insuffisance cardiaque (IC). Nous avons etudie en consultations externes 340 patients atteints d'IC consecutifs, qui affichaient un rythme sinusal. Nous avons effectue une echocardiographie 1,6 [+ or -] 0,4 mois apres le conge de l'hopital. Le parametre devaluation (MSC/AV) etait compose des elements suivants : mort subite cardiaque, fibrillation ventriculaire ou tachycardie ventriculaire soutenue. Pendant la periode de suivi (36 [+ or -] 9 mois) le MSC/AVest survenu chez 48 patients (14,1 %). Al'aide d'une analyse de regression multivariee de Cox comprenant dans le modele la FEVG, le rapport des vitesses diastoliques precoces transmitrale/anneau mitral (E/E'), le SLG, la DM et le ratio SLG/DM, le ratio SLG/DM etait le meilleur facteur predictif independant pour le SCD/VA (rapport de risques instantanes (RRI) de 3,22 avec un intervalle de confiance a 95 % de 1,72 a 6,15, p = 0,03). L'inclusion de la FEVG, de la vitesse annulaire transmitrale systolique, du rapport E/E', du SLG et de la DM separement avec le ratio SLG/DM a montre que le ratio SLG/DM demeure le meilleur facteur predictif de MSC/AV (chacun p < 0,05). La valeur predictive limite optimale du ratio SLG/DM pour le MSC/AV etait de -0,20 %/ms (sensibilite de 80 %, specificite de 76 %). Sans egard a la FEVG, la survie sans evenement etait nettement meilleure chez les patients avec un ratio SLG/DM [less than or equal to] -0,2 %/ms (log-rank, p < 0,001). En conclusion, le ratio SLG/DM pourrait ameliorer la stratification du risque cardiovasculaire chez les sujets atteints d'IC. [Traduit par la Redaction] Mots-cles : insuffisance cardiaque, arythmie ventriculaire maligne, stratification du risque cardiovasculaire, imagerie de strain 2D, strain longitudinal global, dispersion mecanique, ratio SLG/DM., Introduction Cardiac imaging is indispensable for managing the care of heart failure (HF) patients. Prognosis in cardiac disease is closely related to systolic function, which is commonly assessed using left [...]

Published
2017
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11. PENTOXIFYLLINE AND INFLAMMATION MARKERS IN PATIENTS WITH ACUTE CORONARY SYNDROME.

Author

BRIE, DANIEL MIRON, MORNOS, CRISTIAN, BRIE, DIDUTA ALINA, CONSTANTIN, TUDOR LUCA, PETRESCU, LUCIAN, and BORUGA, MADALINA

Subjects
ACUTE coronary syndrome, PENTOXIFYLLINE
Abstract

Copyright of Farmacia is the property of Societatea de Stiinte Farmaceutice Romania and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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12. Betablockers and Ivabradine Titration According to Exercise Test in LV Only Fusion CRT Pacing

Author

Vacarescu, Cristina, primary, Luca, Constantin-Tudor, additional, Feier, Horea, additional, Gaiță, Dan, additional, Crișan, Simina, additional, Negru, Alina-Gabriela, additional, Iurciuc, Stela, additional, Goanță, Emilia-Violeta, additional, Mornos, Cristian, additional, Lazăr, Mihai-Andrei, additional, Streian, Caius-Glad, additional, Arnăutu, Diana-Aurora, additional, Turi, Vladiana-Romina, additional, and Cozma, Dragos, additional

Published
2022
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15. Early detection of anthracycline-mediated cardiotoxicity: the value of considering both global longitudinal left ventricular strain and twist

Author

Mornos, Cristian and Petrescu, Lucian

Subjects
Heart ventricle, Left -- Physiological aspects -- Health aspects, Heart muscle -- Physiological aspects -- Health aspects, Anthracyclines -- Physiological aspects -- Health aspects, Biological sciences
Abstract

Anthracyclines are important anticancer drugs, but their use is limited by cardiotoxicity. Left ventricular ejection fraction (LVEF) is often inadequate to detect myocardial disease induced by chemotherapy. Tissue Doppler and bidimensionalstrain imaging could detect LV myocardial dysfunction earlier than LVEF. In drug-induced cardiotoxicity, torsional and longitudinal LV deformations [LV twist (LVtw), radial strain (GRS), global longitudinal strain (GLS)] are damaged. We assessed whether a new index, GLSxLVtw, could predict future anthracycline-induced cardiomyopathy. Echocardiography, troponin, and natriuretic peptide determination were prospectively performed in 74 patients before and after 6, 12, 24, and 52 weeks of anthracycline treatment. These patients were treated for breast cancer, Hodgkin's or non-Hodgkin's lymphoma, acute lymphoblastic or myeloblastic leukaemia, or osteosarcoma. At 6 weeks after initiation of chemotherapy, isovolumic relaxation time, systolic mitral annular velocity, LVGLS, LVGRS, LV apical rotation, LVtw, and GLSxLVtw deteriorated, and troponin levels became elevated (all p < 0.05 by ANOVA) before LVEF decreased. The receiver operating characteristic curves identified early deterioration of GLSxLVtw as the best predictor of later cardiotoxicity (area under curve = 0.93), followed by GLS (0.84) and LV apical rotation (0.81) deterioration. In conclusion, early change in the GLSxLVtw index seems to be a good predictor of future development of anthracycline-induced cardiotoxicity. Key words: anthracycline-mediated cardiomyopathy, left ventricular function, left ventricular ejection fraction, bidimensionalstrain imaging, left ventricular deformation, global longitudinal strain, twist. Les anthracyclines sont d'importants agents anticancereux, mais leur utilisation est limitee par leur cardiotoxicite. La fraction d'ejection ventriculaire gauche (FEVG) est souvent inadequate pour detecter un dommage au myocarde induit par la chimiotherapie. L'imagerie Doppler tissulaire et l'imagerie de strain bidimensionnelle pourraient detecter la dysfonction myocardique precoce du VG. En situation de cardiotoxicite provoquee par le medicament, les deformations de torsion et longitudinales du VG [torsion du VG (VGT), le strain radial (GRS) et le strain global longitudinal (GLS)] sont affectees. Nous avons evalue si un nouvel indice, GLSxVGT, pourrait predire une cardiomyopathie eventuelle provoquee par les anthracyclines. L'echocardiographie et la determination de la troponine et des peptides natriuretiques ont ete realisees de maniere prospective chez 74 patients avant et apres 6,12, 24 et 52 semaines de traitement aux anthracyclines. Ces patients etaient traites pour un cancer du sein, un lymphome Hodgkinien et non-Hodgkinien, une leucemie lymphoblastique ou myeloblastique, ou un osteosarcome. Six semaines apres le debut de la chimiotherapie, le temps de relaxation isovolumique, la velocite systolique annulaire mitrale, le GLS, le GRS, la rotation apicale et la torsion du VG de meme que l'indice GLSxVGT se deterioraient, et les niveaux de troponine s'elevaient (p < 0,05 en ANOVA pour tous les parametres), avant que la FEVG ne decroisse. Les courbes des caracteristiques receveur-operateur ont identifie la deterioration precoce du GLSxVGT comme le meilleur predicteur d'une cardiotoxicite eventuelle (aire sous la courbe = 0,93), suivi de la deterioration du GLS (0,84) et de la rotation apicale du VG (0,81). En conclusion, le changement precoce du nouvel indice GLSxVGT semble etre un bon predicteur du developpement futur d'une cardiotoxicite provoquee par les anthracyclines. [Traduit par la Redaction] Mots-cles: cardiopathie provoquee par les anthracyclines, fonction ventriculaire gauche, fraction d'ejection ventriculaire gauche, imagerie de strain bidimensionnelle, deformation du ventricule gauche, strain global longitudinal, torsion., Introduction Chemotherapy-induced cardiotoxicity remains a significant and unresolved issue when treating cancer patients. Because the cardiotoxic effect is partially dose-dependent, oncologists have begun to decrease the cumulative dose in most [...]

Published
2013
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17. The Relationship Between Type D Personality and the Complexity of Coronary Artery Disease

Author

Enatescu,Virgil Radu, Cozma,Dragos, Tint,Diana, Enatescu,Ileana, Simu,Mihaela, Giurgi-Oncu,Catalina, Lazar,Mihai Andrei, Mornos,Cristian, Enatescu,Virgil Radu, Cozma,Dragos, Tint,Diana, Enatescu,Ileana, Simu,Mihaela, Giurgi-Oncu,Catalina, Lazar,Mihai Andrei, and Mornos,Cristian

Abstract

Virgil Radu Enatescu,1,* Dragos Cozma,2,3,* Diana Tint,4,5 Ileana Enatescu,6 Mihaela Simu,1 Catalina Giurgi-Oncu,1 Mihai Andrei Lazar,2 Cristian Mornos2,3 1Department of Neuroscience, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 2Department of Cardiology 1, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania; 3Institute of Cardiovascular Diseases Timisoara, Timisoara, Romania; 4School of Medicine, Transylvania University, Brasov, Romania; 5Department of Cardiology, ICCO Clinics Brasov, Brasov, Romania; 6Department of Obstetrics and Gynecology-Discipline of Childcare and Neonatology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Timisoara, Romania*These authors contributed equally to this workCorrespondence: Ileana Enatescu Email enatescu.ileana@umft.roDiana Tint Email dianatint@gmail.comPurpose: The relationship between personality traits and cardiovascular disease has gathered sustained interest over the last years, type –D personality (TDP) being significantly associated with coronary artery disease (CAD). However, data regarding the connection between the TDP and the severity of CAD disease is scarce. The aim of our study was to assess the relationship between TDP and the complexity of CAD, and to compare it with other sociodemographic and clinical features.Patients and Methods: We conducted a cross-sectional case-control clinical-based study on 221 consecutive hospitalized patients with chest pain (60 ± 10.2 years; 131 men), referred for coronary angiography.Results: TDP was identified in 42 (19%) patients, using the DS 14 scale. Symptomatology profile was evaluated using the SCL-90 scale. Syntax score was greater in the subgroup of patients with TDP in comparison to non-TDP subgroup (26.21± 12.03 vs 15.49± 8.89, respectively, p< 0.001), and most of SCL-90 symptom dimension

Published
2021

19. Infective Endocarditis in Patients on Chronic Hemodialysis

Author

Pericàs, Juan M., primary, Llopis, Jaume, additional, Jiménez-Exposito, Maria Jesús, additional, Kourany, Wissam M., additional, Almirante, Benito, additional, Carosi, Giampiero, additional, Durante-Mangoni, Emanuele, additional, Fortes, Claudio Querido, additional, Giannitsioti, Efthymia, additional, Lerakis, Stamatios, additional, Montagna-Mella, Rodrigo, additional, Ambrosioni, Juan, additional, Tan, Ru-San, additional, Mestres, Carlos A., additional, Wray, Dannah, additional, Pachirat, Orathai, additional, Moreno, Asuncion, additional, Chu, Vivian H., additional, de Lazzari, Elisa, additional, Fowler, Vance G., additional, Miró, Jose M., additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Oses, Pablo Fernandez, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Altclas, Javier, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Tan, Ren, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, Passos de Brito, Ana Cláudia, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Siciliano, Rinaldo Focaccia, additional, Varejao Strabelli, Tania Mara, additional, Campos Vieira, Marcelo Luiz, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Cereceda, M., additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Gonzalez, Javier, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, CHU Catherine, additional, Doco-Lecompte, Thanh, additional, Selton-Suty, Christine, additional, Casalta, Jean-Paul, additional, Fournier, Pierre-Edouard, additional, Habib, Gilbert, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Sophia Athanasia, Carl Neuerburg, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Skoutelis, Athanasios, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Wanounou, Maor, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Iossa, Domenico, additional, Orlando, Serena, additional, Ursi, Maria Paola, additional, Pafundi, Pia Clara, additional, D’Amico, Fabiana, additional, Bernardo, Mariano, additional, Cuccurullo, Susanna, additional, Dialetto, Giovanni, additional, Covino, Franco Enrico, additional, Manduca, Sabrina, additional, Della Corte, Alessandro, additional, De Feo, Marisa, additional, Tripodi, Marie Françoise, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif-Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Edathodu, Jameela, additional, Halim, Magid, additional, Liew, Yee-Yun, additional, Lejko-Zupanc, Tatjana, additional, Logar, Mateja, additional, Mueller-Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manel, additional, Azqueta, Manuel, additional, Brunet, Merce, additional, Castro, Pedro, additional, De Lazzari, Elisa, additional, Falces, Carlos, additional, Fuster, David, additional, Fita, Guillermina, additional, Garcia- de- la- Maria, Cristina, additional, Garcia-Gonzalez, Javier, additional, Gatell, Jose M., additional, Marco, Francesc, additional, Miró, José M., additional, Ortiz, José, additional, Ninot, Salvador, additional, Paré, J. Carlos, additional, Pericas, Juan M., additional, Quintana, Eduard, additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Tellez, Adrian, additional, Tolosana, José M., additional, Vidal, Barbara, additional, Vila, Jordi, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez-Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez-Créixems, Marta, additional, Solis, Jorge, additional, Fernandez-Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg-Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Wang, Andrew, additional, Woods, Christopher W., additional, Cantey, Robert, additional, Steed, Lisa, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara-Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Peterson, Gail, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, and Cabell, Christopher H., additional

Published
2021
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22. Three-Dimensional Transesophageal Echocardiography as an Alternative to Multidetector Computed Tomography in Aortic Annular Diameter Measurements for Transcatheter Aortic Valve Implantation

Author

Dima, Ciprian Nicusor, primary, Gaspar, Marian, additional, Mornos, Cristian, additional, Mornos, Aniko, additional, Deutsch, Petru, additional, Cioloca, Horia, additional, Cerbu, Simona, additional, Dinu, Mihai, additional, Hoinoiu, Bogdan, additional, Luca, Constantin Tudor, additional, and Petrescu, Lucian, additional

Published
2021
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24. Exercise test is essential in LV-only fusion CRT pacing without right ventricle lead

Author

Vacarescu, Cristina, Cozma, Dragos, Petrescu, Lucian, Dragan, Simona, Mornos, Cristian, Crisan, Simina, Feier, Horea, Lazar, Mihai-Andrei, Cozlac, Ramona Alina, and Luca, Constantin Tudor

Subjects
Male, Heart Ventricles, exercise test, cardiac resynchronization therapy, Middle Aged, constant fusion pacing, Treatment Outcome, LV-only pacing, Cardiovascular Diseases, Echocardiography, Clinical Interventions in Aging, Humans, Female, Heart Atria, Prospective Studies, Exercise, Original Research, Follow-Up Studies
Abstract

Cristina Vacarescu,1 Dragos Cozma,1,2 Lucian Petrescu,1,2 Simona Dragan,1,2 Cristian Mornos,1,2 Simina Crisan,1,2 Horea Feier,1,2 Mihai-Andrei Lazar,1 Ramona Alina Cozlac,1,2 Constantin Tudor Luca1,21Cardiology Department, Victor Babeș University of Medicine and Pharmacy, Timișoara, Romania; 2Cardiology Department, Institute of Cardiovascular Diseases, Timișoara, RomaniaPurpose: Left ventricle (LV)-only pacing is non-inferior to biventricular pacing but permanent fusion pacing is needed to ensure cardiac resynchronization therapy (CRT) responsiveness. The role of systematic exercise testing (ET) in these patients has not been established. This study was designed to assess clinical and therapeutic implications (device programming/drugs) of systematic ET in patients requiring fusion-pacing CRT without anright ventricle (RV) lead.Methods: Consecutive patients with a right atrium/LV-only dual-chamber (DDD) pacing system were included. Prospective data were obtained: device interrogation, ET, and echocardiography at every 6-month follow-up visit. CRT assessment during ET included maximal heart rate, beat-to-beat echocardiography analysis of LV fusion pacing, LV loss of capture, and improvement in exercise capacity. If LV loss of capture or unsatisfactory LV fusion pacing occurred, reprogramming was individualized for each patient and ET redone.Results: A total of 55 patients (29 male) aged 62±11 years were included. During follow-up (39±18 months), a total of 235 ETs were performed, with mean exercise load 6.4±1.3 metabolic equivalents of task (118±35 W, maximal heart rate 119±17 beats/min). Twenty patients (36%) had inadequate pacing or loss of LV capture during ET, due to exceeding the maximum tracking rate (11%), chronotropic incompetence (7%), and LV pacing outside the fusion-pacing band (18%), caused by physiological shortening of the PR interval or exagerated LV preexcitation during maximum exercise. Post-ET CRT-device optimization included reprogramming of rate-adaptive atrioventricular interval (total decrease 23±8 ms), individualized programming of maximum tracking rate, or rate-response function. Drug optimization was performed in 32% of patients, and ET redone in 36%.Conclusion: In one of three ETs, an intervention in device and medication optimization was done to ensure a better outcome. Routine ET should be a standard approach to maximize fusion-pacing CRT response during follow-up.Keywords: cardiac resynchronization therapy, LV-only pacing, exercise test, constant fusion pacing

Published
2019

27. Exercise test is essential in LV-only fusion CRT pacing without right ventricle lead

Author

Vacarescu,Cristina, Cozma,Dragos, Petrescu,Lucian, Dragan,Simona, Mornos,Cristian, Crisan,Simina, Feier,Horea, Lazar,Mihai-Andrei, Cozlac,Ramona Alina, Luca,Constantin Tudor, Vacarescu,Cristina, Cozma,Dragos, Petrescu,Lucian, Dragan,Simona, Mornos,Cristian, Crisan,Simina, Feier,Horea, Lazar,Mihai-Andrei, Cozlac,Ramona Alina, and Luca,Constantin Tudor

Abstract

Cristina Vacarescu,1 Dragos Cozma,1,2 Lucian Petrescu,1,2 Simona Dragan,1,2 Cristian Mornos,1,2 Simina Crisan,1,2 Horea Feier,1,2 Mihai-Andrei Lazar,1 Ramona Alina Cozlac,1,2 Constantin Tudor Luca1,21Cardiology Department, Victor BabeÈ™ University of Medicine and Pharmacy, TimiÈ™oara, Romania; 2Cardiology Department, Institute of Cardiovascular Diseases, TimiÈ™oara, RomaniaPurpose: Left ventricle (LV)-only pacing is non-inferior to biventricular pacing but permanent fusion pacing is needed to ensure cardiac resynchronization therapy (CRT) responsiveness. The role of systematic exercise testing (ET) in these patients has not been established. This study was designed to assess clinical and therapeutic implications (device programming/drugs) of systematic ET in patients requiring fusion-pacing CRT without an right ventricle (RV) lead.Methods: Consecutive patients with a right atrium/LV-only dual-chamber (DDD) pacing system were included. Prospective data were obtained: device interrogation, ET, and echocardiography at every 6-month follow-up visit. CRT assessment during ET included maximal heart rate, beat-to-beat echocardiography analysis of LV fusion pacing, LV loss of capture, and improvement in exercise capacity. If LV loss of capture or unsatisfactory LV fusion pacing occurred, reprogramming was individualized for each patient and ET redone.Results: A total of 55 patients (29 male) aged 62±11 years were included. During follow-up (39±18 months), a total of 235 ETs were performed, with mean exercise load 6.4±1.3 metabolic equivalents of task (118±35 W, maximal heart rate 119±17 beats/min). Twenty patients (36%) had inadequate pacing or loss of LV capture during ET, due to exceeding the maximum tracking rate (11%), chronotropic incompetence (7%), and LV pacing outside the fusion-pacing band (18%), caused by physiological shortening of the PR interval or exagerated LV preexcitation during maximum exercis

Published
2019

30. Reduced ejection fraction heart failure – new data from multicenter studies and national registries regarding general and elderly populations: hopes and disappointments

Author

Crisan,Simina, Petrescu,Lucian, Lazar,Mihai, Vacarescu,Cristina, Nicola,Alina-Ramona, Cozma,Dragos, Mornos,Cristian, Luca,Constantin Tudor, Crisan,Simina, Petrescu,Lucian, Lazar,Mihai, Vacarescu,Cristina, Nicola,Alina-Ramona, Cozma,Dragos, Mornos,Cristian, and Luca,Constantin Tudor

Abstract

Simina Crişan,1,2 Lucian Petrescu,1,2 Mihai Andrei Lazăr,1,2 Cristina Văcărescu,1,2 Alina-Ramona Nicola,1 Dragoş Cozma,1,2 Cristian Mornoş,1,2 Constantin Tudor Luca1,2 1Cardiology Department, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania; 2Institute of Cardiovascular Diseases, Timisoara, Romania Abstract: The evaluation of patients diagnosed with impaired systolic function heart failure represents a great challenge, in both the general and elderly population. We consider that elderly patients are the most severely affected by this disease that represents the final impact of cardiovascular disease continuum. Cardiovascular diseases are associated with serious morbidity and mortality, and considerable health care costs related to diagnosis and treatment. In this report we discuss some controversies regarding methods of heart failure evaluation as well as therapeutic steps and devices, including: reparatory therapeutic steps and initiation of therapy with loop diuretics, inconsistent dose titration for angiotensin-converting enzyme inhibitors/angiotensin receptor blocker and beta blockers, as well as novel therapies, such as angiotensin receptor neprilysin inhibitor and treatments that directly improve cardiomyocyte function. We conclude that, beyond technical progress, which is raising the cost of therapy for patients with heart failure, more careful monitoring of patient progress through clinical and paraclinical control visits, both at medical facilities and at home, would have greater impact and be more cost-effective. Physical therapy and promoting emotional and psychological wellbeing, to maintain a positive state of mind, contribute substantially to the quality of life and life expectancy, and are most important in elderly people who are most affected by dramatic reductions in wellbeing. Unfortunately, for many patients with severe impairment of left ventricular ejection fraction, these goals and therapeutic procedures are often lack

Published
2018

32. Prognostic impact of blood pressure and heart rate at admission on in-hospital mortality after primary percutaneous intervention for acute myocardial infarction with ST-segment elevation in western Romania

Author

Bordejevic,Diana, Caruntu,Florina, Mornos,Cristian, Olariu,Ioan, Petrescu,Lucian, Tomescu,Mirela, Citu,Ioana, Mavrea,Adelina, Pescariu,Sorin, Bordejevic,Diana, Caruntu,Florina, Mornos,Cristian, Olariu,Ioan, Petrescu,Lucian, Tomescu,Mirela, Citu,Ioana, Mavrea,Adelina, and Pescariu,Sorin

Abstract

Diana Aurora Bordejevic,1,* Florina Caruntu,1,* Cristian Mornos,2 Ioan Olariu,2 Lucian Petrescu,2 Mirela Cleopatra Tomescu,1 Ioana Citu,1 Adelina Mavrea,1 Sorin Pescariu2 1Internal Medicine Department, 2Cardiology Department, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania *These authors contributed equally to this work Background: The purpose of this retrospective study was to evaluate the prognostic impact of systolic blood pressure (SBP) and heart rate (HR) on in-hospital mortality in ST-segment elevation acute myocardial infarction (STEMI) patients, after primary percutaneous intervention (PCI). Patients and methods: The study included 294 patients admitted for STEMI. They were divided into five groups according to the SBP at admission: group I, <105 mmHg; group II, 105–125 mmHg; group III, 126–140 mmHg; group IV, 141–158 mmHg; and group V, ≥159 mmHg. Increased HR was defined as ≥80 beats per minute (bpm). In-hospital death was defined as all-cause death during admission and classified into cardiac and noncardiac death. Results: Among the 294 patients admitted for STEMI, 218 (74%) were men. The mean age was 62±17 years. In-hospital mortality rate was 6% (n=18), with 11 (3.7%) deaths having cardiac causes. The highest mortality was registered in group I (n=9, 16%, P=0.018). Compared to the other groups, group I patients were older (P=0.033), more often smokers (P=0.026), and had a history of myocardial infarction (P=0.003), systemic hypertension (P=0.023), diabetes (P=0.041), or chronic kidney disease (P=0.0200). They more often had a HR ≥80 bpm (P=0.028) and a Killip class 3 or 4 at admission (P=0.020). The peak creatine phosphokinase-MB level was significantly higher in this group (P=0.005), while the angiographic findings more often identified as culprit lesions were the right coronary artery (P=0.005), the left main trunk (P=0.040)

Published
2017

33. Prognostic impact of blood pressure and heart rate at admission on in-hospital mortality after primary percutaneous intervention for acute myocardial infarction with ST-segment elevation in western Romania

Author

Bordejevic, Diana, primary, Caruntu, Florina, additional, Mornos, Cristian, additional, Olariu, Ioan, additional, Petrescu, Lucian, additional, Tomescu, Mirela, additional, Citu, Ioana, additional, Mavrea, Adelina, additional, and Pescariu, Sorin, additional

Published
2017
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34. Monoamine oxidase inhibition improves vascular function in mammary arteries from nondiabetic and diabetic patients with coronary heart disease

Author

Lighezan, Rodica, primary, Sturza, Adrian, additional, Duicu, Oana M., additional, Ceausu, Raluca A., additional, Vaduva, Adrian, additional, Gaspar, Marian, additional, Feier, Horea, additional, Vaida, Monica, additional, Ivan, Viviana, additional, Lighezan, Daniel, additional, Muntean, Danina M., additional, and Mornos, Cristian, additional

Published
2016
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36. Validated Risk Score for Predicting 6‐Month Mortality in Infective Endocarditis

Author

Park, Lawrence P., primary, Chu, Vivian H., additional, Peterson, Gail, additional, Skoutelis, Athanasios, additional, Lejko‐Zupa, Tatjana, additional, Bouza, Emilio, additional, Tattevin, Pierre, additional, Habib, Gilbert, additional, Tan, Ren, additional, Gonzalez, Javier, additional, Altclas, Javier, additional, Edathodu, Jameela, additional, Fortes, Claudio Querido, additional, Siciliano, Rinaldo Focaccia, additional, Pachirat, Orathai, additional, Kanj, Souha, additional, Wang, Andrew, additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Fernandez Oses, Pablo, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, de Brito, Ana Cláudia Passos, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Strabelli, Tania Mara Varejao, additional, Vieira, Marcelo Luiz Campos, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, Catherine, additional, Doco‐Lecompte, Thanh, additional, Selton‐Suty, Christine, additional, Casalta, Jean‐Paul, additional, Fournier, Pierre‐Edouard, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Athanasia, Sophia, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Giannitsioti, Efthymia, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Cahan, Amos, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Durante‐Mangoni, Emanuele, additional, Mattucci, Irene, additional, Pinto, Daniela, additional, Agrusta, Federica, additional, Senese, Alessandra, additional, Ragone, Enrico, additional, Utili, Riccardo, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Carosi, Giampiero, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif‐Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Halim, Magid, additional, Liew, Yee‐Yun, additional, Tan, Ru‐San, additional, Logar, Mateja, additional, Mueller‐Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manuel, additional, Armero, Yolanda, additional, Azqueta, Manuel, additional, Castañeda, Ximena, additional, Cervera, Carlos, additional, Falces, Carlos, additional, Garcia‐de‐la‐Maria, Cristina, additional, Fita, Guillermina, additional, Gatell, Jose M., additional, Heras, Magda, additional, Llopis, Jaime, additional, Marco, Francesc, additional, Mestres, Carlos A., additional, Miró, José M., additional, Moreno, Asuncion, additional, Ninot, Salvador, additional, Paré, Carlos, additional, Pericas, Juan M., additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sitges, Marta, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez‐Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez‐Créixems, Marta, additional, Solis, Jorge, additional, Almirante, Benito, additional, Fernandez‐Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg‐Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Fowler, Vance G., additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Woods, Christopher W., additional, Lerakis, Stamatios, additional, Cantey, Robert, additional, Steed, Lisa, additional, Wray, Dannah, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara‐Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, Cabell, Christopher H., additional, Baloch, Khaula, additional, Dixon, Christy C., additional, Harding, Tina, additional, Jones‐Richmond, Marian, additional, Sanderford, Bob, additional, Stafford, Judy, additional, Anstrom, Kevin, additional, Bayer, Arnold S., additional, Karchmer, A. W., additional, Sexton, Daniel J., additional, Chu, Vivian, additional, Durack, David T., additional, Eykyn, Susannah, additional, and Moreillon, Phillipe, additional

Published
2016
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37. Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke

Author

Barsic, Bruno, Dickerman, Stuart, Krajinovic, Vladimir, Pappas, Paul, Altclas, Javier, Carosi, Giampiero, Casabé, José H., Chu, Vivian H., Delahaye, Francois, Edathodu, Jameela, Fortes, Claudio Querido, Olaison, Lars, Pangercic, Ana, Patel, Mukesh, Rudez, Igor, Tamin, Syahidah Syed, Vincelj, Josip, Bayer, Arnold S., Wang, Andrew, Clara, Liliana, Sanchez, Marisa, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Casabé, José, Cortes, Claudia, Kogan, Silvia, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Eisen, Damon, Grigg, Leeanne, Street, Alan, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Harkness, John, Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, De Brito, Ana Cláudia Passos, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Strabelli, Tania Mara Varejao, Vieira, Marcelo Luiz Campos, De Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, De Oliveira Ramos, Auristela, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Santos, Marisa, Weksler, Clara, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Bukovski, Suzana, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, Kholy, Amani El, Mishaal, Marwa, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, Catherine, Doco Lecompte, Thanh, Selton Suty, Christine, Casalta, Jean Paul, Fournier, Pierre Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Violette, Jérémie, Chevalier, Florent, Jeu, Antoine, Rusinaru, Dan, Sorel, Claire, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Germa Christoph, Neuerburg, Carl, Mazaheri, Bahram, Naber, Christoph, Athanasia, Sofia, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, D. M. Vinod, Venugopal, Krishnan, Hannan, Margaret, Hurley, John, Cahan, Amos, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Tripodi, Marie Françoise, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante Mangoni, Emanuele, Irene, Mattucci, Ragone, Enrico, Utili, Riccardo, Cecchi, Enrico, Rosa, Francesco De, Forno, Davide, Imazio, Massimo, Trinchero, Rita, Tebini, Alessandro, Grossi, PAOLO ANTONIO, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Magri, Silvia, Signorini, Liana, Baban, Tania, Kanafani, Zeina, Kanj, Souha S., Sfeir, Jad, Yasmine, Mohamad, Abidin, Imran, Martínez, Eduardo Rivera, Nieto, Gabriel Israel Soto, Van Der Meer, Jan T. M., Chambers, Stephen, Murdoch, David R., Holland, David, Morris, Arthur, Raymond, Nigel, Read, Kerry, Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O. M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Vinogradova, Tatiana, Halim, Magid, Lum, Luh Nah, Tan, Ru San, Lejko Zupanc, Tatjana, Logar, Mateja, Mueller Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Del Rio, Ana, Falces, Carlos, Garcia De La Maria, Cristina, Fita, Guillermina, Gatell, Jose M., Marco, Francesc, Mestres, Carlos A., Miró, José M., Moreno, Asuncion, Ninot, Salvador, Paré, Carlos, Pericas, Joan, Ramirez, Jose, Rovira, Irene, Sitges, Marta, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Bouza, Emilio, Fernández, Miguel Angel Garcia, Gonzalez Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez Créixems, Marta, Solis, Jorge, Almirante, Benito, Fernandez Hidalgo, Nuria, Tornos, Pilar, De Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Snygg Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Corey, G. Ralph, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Lalani, Tahaniyat, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Woods, Christopher W., Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Wray, Dannah, Dickerman, Stuart A., Bonilla, Hector, Di Persio, Joseph, Salstrom, Sara Jane, Baddley, John, Peterson, Gail, Stancoven, Amy, Afonso, Luis, Kulman, Theresa, Levine, Donald, Rybak, Michael, Cabell, Christopher H., Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie (Hôpital Louis Pradel), Hospices Civils de Lyon (HCL), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, MESH: Endocarditis, Time Factors, Medizin, 030204 cardiovascular system & hematology, endocarditis, valve replacement, surgery, Cohort Studies, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 030212 general & internal medicine, Hospital Mortality, MESH: Inpatients, Stroke, MESH: Cohort Studies, MESH: Aged, MESH: Middle Aged, MESH: Cardiac Surgical Procedures, Endocarditis, Mortality rate, Hazard ratio, Middle Aged, stroke, 3. Good health, Cardiac surgery, Infectious Diseases, Infective endocarditis, Female, Cohort study, Adult, Microbiology (medical), medicine.medical_specialty, MESH: Stroke, 03 medical and health sciences, medicine, Humans, MESH: Hospital Mortality, Cardiac Surgical Procedures, Aged, Inpatients, MESH: Humans, Proportional hazards model, business.industry, MESH: Time Factors, MESH: Adult, Odds ratio, medicine.disease, MESH: Male, Surgery, business, MESH: Female
Abstract

International audience; BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were obtained from the International Collaboration on Endocarditis-Prospective Cohort Study of 4794 patients with definite IE who were admitted to 64 centers from June 2000 through December 2006. Multivariate logistic regression and Cox regression analyses were performed to estimate the impact of early surgery on hospital and 1-year mortality after adjustments for other significant covariates. RESULTS: Of the 857 patients with IE complicated by ischemic stroke syndromes, 198 who underwent valve replacement surgery poststroke were available for analysis. Overall, 58 (29.3%) patients underwent early surgical treatment vs 140 (70.7%) patients who underwent late surgical treatment. After adjustment for other risk factors, early surgery was not significantly associated with increased in-hospital mortality rates (odds ratio, 2.308; 95% confidence interval [CI], .942-5.652). Overall, probability of death after 1-year follow-up did not differ between 2 treatment groups (27.1% in early surgery and 19.2% in late surgery group, P = .328; adjusted hazard ratio, 1.138; 95% CI, .802-1.650). CONCLUSIONS: There is no apparent survival benefit in delaying surgery when indicated in IE patients after ischemic stroke. Further observational analyses that include detailed pre- and postoperative clinical neurologic findings and advanced imaging data (eg, ischemic stroke size), may allow for more refined recommendations on the optimal timing of valvular surgery in patients with IE and recent stroke syndromes.

Published
2013
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38. HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort

Author

Chambers, Stephen T, Murdoch, David, Morris, Arthur, Holland, David, Pappas, Paul, Almela, Manel, Fernández Hidalgo, Nuria, Almirante, Benito, Bouza, Emilio, Forno, Davide, Rio, Ana del, Hannan, Margaret M., Harkness, John, Kanafani, Zeina A., Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W., Wray, Dannah, Corey, G. Ralph, Chu, Vivian H., Clara, Liliana, Sanchez, Marisa, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Casabé, José, Cortes, Claudia, Altclas, Javier, Silvia Kogan, Sanatorio, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Eisen, Damon, Grigg, Leeanne, Street, Alan, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, de Brito, Ana Cláudia Passos, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Strabelli, Tania Mara Varejao, Vieira, Marcelo Luiz Campos, de Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, Fortes, Claudio Querido, de Oliveira Ramos, Auristela, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Santos, Marisa, Weksler, Clara, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Barsic, Bruno, Bukovski, Suzana, Krajinovic, Vladimir, Pangercic, Ana, Rudez, Igor, Vincelj, Josip, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, Kholy, Amani El, Mishaal, Marwa, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, Catherine, Doco Lecompte, Thanh, Selton Suty, Christine, Casalta, Jean Paul, Fournier, Pierre Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Francois, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Violette, Jérémie, Chevalier, Florent, Jeu, Antoine, Rusinaru, Dan M. D., Sorel, Claire, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Christoph, Neuerburg, Carl, Mazaheri, Bahram, Athanasia, Sofia, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, Vinod, Venugopal, Krishnan, Hannan, Margaret, Hurley, John, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Tripodi, Marie Françoise, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante Mangoni, Emanuele, Irene, Mattucci, Ragone, Enrico, Utili, Riccardo, Cecchi, Enrico, De Rosa, Francesco, Imazio, Massimo, Trinchero, Rita, Tebini, Alessandro, Grossi, PAOLO ANTONIO, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Carosi, Giampiero, Magri, Silvia, Signorini, Liana, Baban, Tania, Kanafani, Zeina, Kanj, Souha S., Sfeir, Jad, Yasmine, Mohamad, Abidin, Imran, Tamin, Syahidah Syed, Martínez, Eduardo Rivera, Nieto, Gabriel Israel Soto, van der Meer, Jan T. M., Chambers, Stephen, Murdoch, David R., Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O. M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Edathodu, Jameela, Halim, Magid, Lum, Luh Nah, Tan, Ru San, Lejko Zupanc, Tatjana, Logar, Mateja, Mueller Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Falces, Carlos, Garcia de la Maria, Cristina, Fita, Guillermina, Gatell, Jose M., Marco, Francesc, Mestres, Carlos A., Miró, José M., Moreno, Asuncion, Ninot, Salvador, Paré, Carlos, Pericas, Joan, Ramirez, Jose, Rovira, Irene, Sitges, Marta, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Fernández, Miguel Angel Garcia, Gonzalez Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez Créixems, Marta, Solis, Jorge, Fernandez Hidalgo, Nuria, Tornos, Pilar, de Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Olaison, Lars, Snygg Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Wang, Andrew, Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Dickerman, Stuart A., Bonilla, Hector, Dipersio, Joseph, Salstrom, Sara Jane, Baddley, John, Patel, Mukesh, Peterson, Gail, Stancoven, Amy, Afonso, Luis, Kulman, Theresa, Levine, Donald, Rybak, Michael, Cabell, Christopher H., Baloch, Khaula, Dixon, Christy C., Vance G., Fowler J. r., Harding, Tina, Jones Richmond, Marian, Park, Lawrence P., Redick, Thomas, Stafford, Judy, Anstrom, Kevin, Bayer, Arnold S., Karchmer, A. W., Sexton, Daniel J., Cabell, Christopher H, Chu, Vivian, Durack, David T., Eykyn, Susannah, Moreillon, Phillipe, Universitat de Barcelona, University of Otago [Dunedin, Nouvelle-Zélande], Auckland City Hospital, Microbiology Laboratory, Middlemore Hospital, Duke University Medical Center, Clinical and experimental neuroimmunology [IDIBAPS], Institut d'Investigacions Biomèdiques August Pi i Sunyer, Vall d'Hebron University Hospital [Barcelona], Hospital Universitario Gregorio Maranon, Hospital Universitario Gregorio Marañón, Cardiologie, Maria Vittoria Hospital [Turin], Mater Hospitals, University of New South Wales [Sydney] (UNSW), American University of Beirut [Beyrouth] (AUB), Uniformed Services University of the Health Sciences (USUHS), Wellington Hospital Private, Royal North Shore Hospital (RNSH), Russian State Medical University, Durham VA Medical Center, and University of South Carolina [Columbia]

Subjects
Aortic valve, Bacterial Diseases, Genetics and Molecular Biology (all), Valvular Disease, Medizin, Eikenella corrodens, Cardiobacterium, Infection control, Cardiovascular, American-heart-association, Biochemistry, Antimicrobial therapy, Cohort Studies, 0302 clinical medicine, Control d'infeccions, Diagnosis, Odds Ratio, Prevalence, 030212 general & internal medicine, Prospective cohort study, Haemophilus Influenzae, 0303 health sciences, Multidisciplinary, biology, Endocarditis, Medicine (all), Statistics, Congenital Heart Disease, Age Factors, Bacterial, 3. Good health, Management, Stroke, medicine.anatomical_structure, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Treatment Outcome, Infective endocarditis, Cohort, [SDV.IMM]Life Sciences [q-bio]/Immunology, Medicine, Profile, Health-care professionals, Kingella, Cardiobacterium-hominis, Cohort study, Research Article, medicine.medical_specialty, Drugs and Devices, Science, Haemophilus, Referral bias, Statistics, Nonparametric, Medical Devices, 03 medical and health sciences, Internal medicine, Kingella Kingae Infection, medicine, Humans, Nonparametric, Aggregatibacter, Endocarditis, Bacterial, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Staphylococcus-aureus, Heart Failure, 030306 microbiology, business.industry, Acute Cardiovascular Problems, Bloodstream Infections, medicine.disease, biology.organism_classification, Surgery, Valve endocarditis, Cardiobacterium hominis, business
Abstract

International audience; The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p < 0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p < 0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p < 0.01) and younger age (OR 0.62; CI 0.49-0.90; p < 0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p < 0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.

Published
2013
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41. Monoamine Oxidases as Potential Contributors to Oxidative Stress in Diabetes: Time for a Study in Patients Undergoing Heart Surgery

Author

Duicu, Oana M., primary, Lighezan, Rodica, additional, Sturza, Adrian, additional, Ceausu, Raluca A., additional, Borza, Claudia, additional, Vaduva, Adrian, additional, Noveanu, Lavinia, additional, Gaspar, Marian, additional, Ionac, Adina, additional, Feier, Horea, additional, Muntean, Danina M., additional, and Mornos, Cristian, additional

Published
2015
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42. The prognostic value of a new Tissue Doppler parameter in patients with heart failure with reduced ejection fraction.

Author

Mornos, Cristian, Crisan, Simina, Petrescu, Lucian, Ionac, Adina, and Cozma, Dragos

Subjects
*HEART failure, *VENTRICULAR ejection fraction, *ECHOCARDIOGRAPHY, *PROGNOSIS
Abstract

Recent data have demonstrated that a new tissue Doppler index, E/(E'×S'), index that includes the ratio between early diastolic transmitral and mitral annulus velocity (E/E'), as well as the systolic mitral annulus velocity (S'), has a good accuracy to predict cardiac death in patients with heart failure (HF). We analyzed the prognostic value of the E/(E'×S') ratio in patients with heart failure with reduced ejection fraction (HFrEF). Methods - Echocardiographic examination was performed in 166 patients hospitalized with the diagnosis of heart failure with reduced ejection fraction, before discharge as well as one month later. Worsening of E/(E'×S') was defined as a value greater than the previous value determined at discharge. The primary event consisted of cardiac death or hospital admission due to HF worsening. Results - During follow-up (34±8.8 months) cardiac events were recorded for 113 patients (68%). The optimal cut-off value for E/(E'×S') ratio was 1.96 with 84% sensitivity and 80% specificity. At discharge, 60 patients (36,2%) presented a value of the E/(E'×S') index =1.96 (group I) and 106 patients (63.8%) encountered a value of the E/(E'×S') index >1.96 (group II). The composite end point was significantly higher in group II than in group I (95 events, 89.6% versus 18 events, 30%, p<0.001). Patients with an E/(E'×S') ratio >1.96 at discharge and its worsening after one month presented the worst prognosis (p<0.05). Conclusions - In patients with with heart failure with reduced ejection fraction, a value of the E/(E'×S') index >1.96 at hospital discharge associated with its worsening after one month is an important predictor for future cardiac events. [ABSTRACT FROM AUTHOR]

Published
2017

43. Do we need new echocardiographic methods for left ventricle systolic function evaluation in athlets?

Author

Popescu, Irina, Mancas, Silvia, Serbescu, Ioan, Mornos, Cristian, and Ionac, Adina

Subjects
ECHOCARDIOGRAPHY, CARDIAC contraction, ATHLETES, RUGBY football, AEROBIC conditions (Biochemistry)
Abstract

The aim of our study was to evaluate left ventricular (LV) systolic function in a team of elite rugby players using new echocardiographic techniques: Tissue Doppler, two-dimensional (2D) Speckle tracking and threedimensional (3D) echocardiography. Material and Method. Twenty six male athletes from the regional rugby players' team were evaluated. The team was divided in two groups of athletes based on the predominance of dynamic aerobic or anaerobic effort performed: thirteen of them (group 1) - anaerobe effort, the others thirteen (group 2) - aerobic effort. All athletes underwent a complete physical exam, complete 2D and 3D transthoracic echocardiographic exam at rest. Standard 2D measurements, Tissue Doppler parameters, 2D speckle tracking global longitudinal strain (2D GLS) and 3D global longitudinal strain (3D GLS) were evaluated. Results. There were statistically significant differences between the two groups of athletes. Those in group 1 had higher body mass index (BMI) (p=0.002), left atrial area (LAA) (p=0.006), 3D left ventricular enddiastolic and endsystolic volume (LVEDV3D and LVESV3D) (p=0.006 respective p=0.011), 3D left ventricular mass (LVMass3D) (p=0.002), pulse Doppler diastolic A'velocity of lateral mitral annulus (A'lat) (p=0.004), left atrial diameter (LAD) (p=0.001), pulse Doppler systolic velocity of medial mitral annulus (S'med) (p=0.01), mitral annular plane systolic excursion (MAPSE) (p=0.033) than those in group 2, who had higher diastolic E' velocity of lateral (E'lat) and medial (E'med) mitral annulus (p=0.047 respective p=0.021). There were no significant differences of 2D GLS respective 3D GLS between the two groups (p=0.59, respective p=0.27). Athletes who had greater LV hypertrophy and LV mass indexed higher had a better response in tests of anaerobic exercise capacity. There was a statistically significant association between the 3D ejection fraction (EF) and anaerobic and aerobic exercise capacity. Conclusions. Our study revealed interesting interrelations between 2D GLS, 3D GLS, and LV hypertrophy and test results of effort capacity in a group of elite rugby players. [ABSTRACT FROM AUTHOR]

Published
2017

47. Monoamine oxidase inhibition improves vascular function in mammary arteries from nondiabetic and diabetic patients with coronary heart disease1.

Author

Lighezan, Rodica, Sturza, Adrian, Duicu, Oana M., Ceausu, Raluca A., Vaduva, Adrian, Gaspar, Marian, Feier, Horea, Vaida, Monica, Ivan, Viviana, Lighezan, Daniel, Muntean, Danina M., and Mornos, Cristian

Subjects
MONOAMINE oxidase inhibitors, CORONARY disease, HYDROGEN peroxide, ENDOTHELIUM diseases, SELEGILINE, IMMUNOHISTOCHEMISTRY
Abstract

Copyright of Canadian Journal of Physiology & Pharmacology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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