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11,051 results on '"Moore, D. A."'

1. Application of Quantum Graph Theory to Metamaterial Design: Negative Refraction of Acoustic Waveguide Modes

Author: Lawrie, T. M., Starkey, T. A., Tanner, G., Moore, D. B., Savage, P., and Chaplain, G. J.
Subjects: Physics - Applied Physics, Mathematical Physics
Abstract: We leverage quantum graph theory to quickly and accurately characterise acoustic metamaterials comprising networks of interconnected pipes. Anisotropic bond lengths are incorporated in the model that correspond to space-coiled acoustic structures to exhibit dispersion spectra reminiscent of hyperbolic metamaterials. We construct two metasurfaces with embedded graph structure and, motivated by the graph theory, infer and fine-tune their dispersive properties to engineer non-resonant negative refraction of acoustic surface waves at their interface. Agreement between the graph model, full wave simulations, and experiments bolsters quantum graph theory as a new paradigm for metamaterial design., Comment: 8 pages, 5 figures
Published: 2024

2. Imaging of single barium atoms in a second matrix site in solid xenon for barium tagging in a $^{136}$Xe double beta decay experiment

Author: Yvaine, M., Fairbank, D., Soderstrom, J., Taylor, C., Stanley, J., Walton, T., Chambers, C., Iverson, A., Fairbank, W., Kharusi, S. Al, Amy, A., Angelico, E., Anker, A., Arnquist, I. J., Atencio, A., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breslin, J., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cesmecioglu, D., Chambers, E., Chana, B., Chernyak, D., Chiu, M., Collister, R., Cvitan, M., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Dolinski, M. J., Eckert, B., Elbeltagi, M., Elmansali, R., Fatemighomi, N., Foust, B., Fu, Y. S., Gallacher, D., Gallice, N., Giacomini, G., Gillis, W., Gingras, C., Gornea, R., Gratta, G., Hardy, C. A., Hedges, S., Hein, E., Holt, J. D., Hoppe, E. W., Karelin, A., Keblbeck, D., Kotov, I., Kuchenkov, A., Kumar, K. S., Kwiatkowski, A. A., Larson, A., Latif, M. B., Leach, K. G., Lennarz, A., Leonard, D. S., Lewis, H., Li, G., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Majidi, S., Malbrunot, C., Masbou, J., McMichael, K., Peregrina, M. Medina, Moe, M., Mong, B., Moore, D. C., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Pagani, L., Smalley, H. Peltz, Perna, A., Pocar, A., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rescia, S., Richardson, G., Ross, R., Rowson, P. C., Saldanha, R., Sangiorgio, S., Schwartz, S., Sekula, S., Si, L., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O. A., van Bruggen, E., Vidal, M., Walent, M., Wamba, K., Wang, H. W., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wehrfritz, M., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Xu, H., Yang, L., Yu, M., and Zeldovich, O.
Subjects: Physics - Atomic Physics, High Energy Physics - Experiment, Nuclear Experiment
Abstract: Neutrinoless double beta decay is one of the most sensitive probes for new physics beyond the Standard Model of particle physics. One of the isotopes under investigation is $^{136}$Xe, which would double beta decay into $^{136}$Ba. Detecting the single $^{136}$Ba daughter provides a sort of ultimate tool in the discrimination against backgrounds. Previous work demonstrated the ability to perform single atom imaging of Ba atoms in a single-vacancy site of a solid xenon matrix. In this paper, the effort to identify signal from individual barium atoms is extended to Ba atoms in a hexa-vacancy site in the matrix and is achieved despite increased photobleaching in this site. Abrupt fluorescence turn-off of a single Ba atom is also observed. Significant recovery of fluorescence signal lost through photobleaching is demonstrated upon annealing of Ba deposits in the Xe ice. Following annealing, it is observed that Ba atoms in the hexa-vacancy site exhibit antibleaching while Ba atoms in the tetra-vacancy site exhibit bleaching. This may be evidence for a matrix site transfer upon laser excitation. Our findings offer a path of continued research toward tagging of Ba daughters in all significant sites in solid xenon., Comment: 9 pages, 8 figures
Published: 2024

3. Supernova Electron-Neutrino Interactions with Xenon in the nEXO Detector

Author: nEXO Collaboration, Hedges, S., Kharusi, S. Al, Angelico, E., Brodsky, J. P., Richardson, G., Wilde, S., Amy, A., Anker, A., Arnquist, I. J., Arsenault, P., Atencio, A., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breslin, J., Breur, P. A., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L. Q., Cesmecioglu, D., Chambers, E., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Collister, R., Cvitan, M., Dalmasson, J., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Ding, Y. Y., Dolinski, M. J., Eckert, B., Elbeltagi, M., Elmansali, R., Fabris, L., Fairbank, W., Farine, J., Fatemighomi, N., Foust, B., Fu, Y. S., Gallacher, D., Gallice, N., Gillis, W., Goeldi, D., Gorham, A., Gornea, R., Gratta, G., Guan, Y. D., Hardy, C. A., Heffner, M., Hein, E., Holt, J. D., Hoppe, E. W., House, A., Hunt, W., Iverson, A., Kachru, P., Karelin, A., Keblbeck, D., Kuchenkov, A., Kumar, K. S., Larson, A., Latif, M. B., Leach, K. G., Lenardo, B. G., Leonard, D. S., Lewis, H., Li, G., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Majidi, S., Malbrunot, C., Martel-Dion, P., Masbou, J., McMichael, K., Medina-Peregrina, M., Mong, B., Moore, D. C., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Orrell, J. L., Ortega, G. S., Overman, C. T., Pagani, L., Smalley, H. Peltz, Perna, A., Piepke, A., Franco, T. Pinto, Pocar, A., Pratte, J. -F., Rasiwala, H., Ray, D., Raymond, K., Rescia, S., Riot, V., Ross, R., Saldanha, R., Sangiorgio, S., Schwartz, S., Sekula, S., Soderstrom, J., Soma, A. K., Spadoni, F., Sun, X. L., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, R. H. M., Tyuka, O. A., van Bruggen, E., Vidal, M., Viel, S., Walent, M., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wehrfritz, M., Wei, W., Wen, L. J., Wichoski, U., Wu, X. M., Xu, H., Yang, H. B., Yang, L., Yu, M., Yvaine, M., Zeldovich, O., and Zhao, J.
Subjects: High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Theory
Abstract: Electron-neutrino charged-current interactions with xenon nuclei were modeled in the nEXO neutrinoless double-beta decay detector (~5-tonne, 90% ${}^{136}$Xe, 10% ${}^{134}$Xe) to evaluate its sensitivity to supernova neutrinos. Predictions for event rates and detectable signatures were modeled using the MARLEY event generator. We find good agreement between MARLEY's predictions and existing theoretical calculations of the inclusive cross sections at supernova neutrino energies. The interactions modeled by MARLEY were simulated within the nEXO simulation framework and were run through an example reconstruction algorithm to determine the detector's efficiency for reconstructing these events. The simulated data, incorporating the detector response, were used to study the ability of nEXO to reconstruct the incident electron-neutrino spectrum and these results were extended to a larger xenon detector of the same isotope enrichment. We estimate that nEXO will be able to observe electron-neutrino interactions with xenon from supernovae as far as 5 to 8 kpc from earth, while the ability to reconstruct incident electron-neutrino spectrum parameters from observed interactions in nEXO is limited to closer supernovae., Comment: 17 pages, 16 figures
Published: 2024

4. Report from the Workshop on Xenon Detector $0\nu\beta\beta$ Searches: Steps Towards the Kilotonne Scale

Author: Anker, A., Avasthi, A., Brodeur, M., Brunner, T., Byrnes, N. K., Catarineu, N. R., Cottle, A., Englezos, P., Fairbank, W., Díaz, D. González, Guenette, R., Haselschwardt, S. J., Hedges, S., Heffner, M., Holt, J. D., Jamil, A., Jones, B. J. P., Kawada, N., Leardini, S., Lenardo, B. G., Marc, A., Masbou, J., Mistry, K., Mong, B., Monreal, B., Moore, D. C., Nygren, D. R., Olcina, I., Orrell, J. L., Pocar, A., Richardson, G., Rogers, L., Saldanha, R., Sangiorgio, S., Wittweg, C., Xia, Q., Yang, L., and Zennamo, J.
Subjects: Nuclear Experiment
Abstract: These proceedings summarize the program and discussions of the ``Workshop on Xenon Detector $0\nu\beta\beta$ Searches: Steps Towards the Kilotonne Scale'' held on October 25-27 2023 at SLAC National Accelerator Laboratory. This workshop brought together experts from the communities of neutrinoless double-beta decay and dark matter detection, to discuss paths forward for the realization of monolithic experiments with xenon approaching the kilotonne scale., Comment: 7 pages, 2 figures. Proceedings
Published: 2024

5. Validation of a Community-Based Approach Toward Personalized Dementia Risk Reduction: The Kimel Family Centre for Brain Health and Wellness

Author: Anderson, Nicole D., D’Amico, D., Rotenberg, S., Addis, D. R., Gillen, J., Moore, D., Furlano, J. A., Tan, B., Binns, M., Santarossa, M., and Chertkow, H.
Published: 2024
Full Text: View/download PDF

6. An integrated online radioassay data storage and analytics tool for nEXO

Author: Tsang, R. H. M., Piepke, A., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Atencio, A., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhat, A., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L. Q., Cesmecioglu, D., Chambers, C., Chambers, E., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Cohen, J. R., Collister, R., Cvitan, M., Dalmasson, J., Darroch, L., Deslandes, K., DeVoe, R., di Vacri, M. L., Ding, Y. Y., Dolinski, M. J., Echevers, J., Eckert, B., Elbeltagi, M., Elmansali, R., Fabris, L., Fairbank, W., Farine, J., Fu, Y. S., Gallacher, D., Gallina, G., Gautam, P., Giacomini, G., Gillis, W., Gingras, C., Goeldi, D., Gornea, R., Gratta, G., Guan, Y. D., Hardy, C. A., Hedges, S., Heffner, M., Hein, E., Holt, J., Hoppe, E. W., House, A., Hunt, W., Iverson, A., Jamil, A., Jiang, X. S., Karelin, A., Kaufman, L. J., Kotov, I., Krücken, R., Kuchenkov, A., Kumar, K. S., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Majidi, S., Malbrunot, C., Martel-Dion, P., Masbou, J., Massacret, N., McMichael, K., Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Orrell, J. L., Ortega, G. S., Overman, C. T., Peltz-Smalley, H., Perna, A., Franco, T. Pinto, Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rebeiro, B., Rescia, S., Retière, F., Richardson, G., Ringuette, J., Riot, V., Rowson, P. C., Roy, N., Rudolph, L., Saldanha, R., Sangiorgio, S., Schwartz, S., Soderstrom, J., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Barakoohi, E. Teimoori, Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O. A., Underwood, R., van Bruggen, E., Veeraraghavan, V., Vidal, M., Viel, S., Walent, M., Wamba, K., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Wu, S., Wu, X. M., Yang, H., Yang, L., Yvaine, M., Zeldovich, O., Zhao, J., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: Large-scale low-background detectors are increasingly used in rare-event searches as experimental collaborations push for enhanced sensitivity. However, building such detectors, in practice, creates an abundance of radioassay data especially during the conceptual phase of an experiment when hundreds of materials are screened for radiopurity. A tool is needed to manage and make use of the radioassay screening data to quantitatively assess detector design options. We have developed a Materials Database Application for the nEXO experiment to serve this purpose. This paper describes this database, explains how it functions, and discusses how it streamlines the design of the experiment.
Published: 2023

7. Fundamental Symmetries, Neutrons, and Neutrinos (FSNN): Whitepaper for the 2023 NSAC Long Range Plan

Author: Acharya, B., Adams, C., Aleksandrova, A. A., Alfonso, K., An, P., Baeßler, S., Balantekin, A. B., Barbeau, P. S., Bellini, F., Bellini, V., Beminiwattha, R. S., Bernauer, J. C., Bhattacharya, T., Bishof, M., Bolotnikov, A. E., Breur, P. A., Brodeur, M., Brodsky, J. P., Broussard, L. J., Brunner, T., Burdette, D. P., Caylor, J., Chiu, M., Cirigliano, V., Clark, J. A., Clayton, S. M., Daniels, T. V., Darroch, L., Davoudi, Z., de Gouvêa, A., Dekens, W., Demarteau, M., DeMille, D., Deshpande, A., Detwiler, J. A., Dodson, G. W., Dolinski, M. J., Elliott, S. R., Engel, J., Erler, J., Filippone, B. W., Fomin, N., Formaggio, J. A., Friesen, F. Q. L., Fry, J., Fujikawa, B. K., Fuller, G., Fuyuto, K., Gallant, A. T., Gallina, G., Ruiz, A. Garcia, Ruiz, R. F. Garcia, Gardner, S., Gonzalez, F. M., Gratta, G., Gruszko, J., Gudkov, V., Guiseppe, V. E., Gutierrez, T. D., Hansen, E. V., Hardy, C. A., Haxton, W. C., Hayen, L., Hedges, S., Heeger, K. M., Heffner, M., Heise, J., Henning, R., Hergert, H., Hertzog, D. W., Aguilar, D. Hervas, Holt, J. D., Hoogerheide, S. F., Hoppe, E. W., Horoi, M., Howell, C. R., Huang, M., Hutzler, N. R., Imam, K., Ito, T. M., Jamil, A., Janssens, R. V., Jayich, A. M., Jones, B. J. P., Kammel, P., Liu, K. F., Khachatryan, V., King, P. M., Klein, J. R., Kneller, J. P., Kolomensky, Yu. G., Korsch, W., Krücken, R., Kumar, K. S., Launey, K. D., Lawrence, D., Leach, K. G., Lehnert, B., Lenardo, B. G., Li, Z., Lin, H. -W., Longfellow, B., Lopez-Caceres, S., Lunardini, C., MacLellan, R., Markoff, D. M., Maruyama, R. H., Mathews, D. G., Melconian, D., Mereghetti, E., Mohanmurthy, P., Moore, D. C., Mueller, P. E., Mumm, H. P., Nazarewicz, W., Newby, J., Nicholson, A. N., Novitski, E., Ondze, J. C. Nzobadila, O'Donnell, T., Gann, G. D. Orebi, Orrell, J. L., Ouellet, J. L., Parno, D. S., Paschke, K. D., Pastore, S., Pattie Jr, R. W., Petrov, A. A., Pitt, M. L., Plaster, B., Pocanic, D., Pocar, A., Poon, A. W. P., Radford, D. C., Rahangdale, H., Rasco, B. C., Rasiwala, H., Redwine, R. P., Ritz, A., Rogers, L., Ron, G., Saldanha, R., Sangiorgio, S., Sargsyan, G. H., Saunders, A., Savard, G., Schaper, D. C., Scholberg, K., Scielzo, N. D., Seng, C. -Y., Shindler, A., Singh, J. T., Singh, M., Singh, V., Snow, W. M., Soma, A. K., Souder, P. A., Speller, D. H., Stachurska, J., Surukuchi, P. T., Oregui, B. Tapia, Tomalak, O., Torres, J. A., Tyuka, O. A., VanDevender, B. A., Varriano, L., Vogt, R., Walker-Loud, A., Wamba, K., Watkins, S. L., Wietfeldt, F. E., Williams, W. D., Wilson, J. T., Winslow, L., Yan, X. L., Yang, L., Young, A. R., Zheng, X., and Zhou, Y.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: This whitepaper presents the research priorities decided on by attendees of the 2022 Town Meeting for Fundamental Symmetries, Neutrons and Neutrinos, which took place December 13-15, 2022 in Chapel Hill, NC, as part of the Nuclear Science Advisory Committee (NSAC) 2023 Long Range Planning process. A total of 275 scientists registered for the meeting. The whitepaper makes a number of explicit recommendations and justifies them in detail.
Published: 2023

8. Generative Adversarial Networks for Scintillation Signal Simulation in EXO-200

Author: Li, S., Ostrovskiy, I., Li, Z., Yang, L., Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fu, Y. S., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Perna, A., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., and Tsang, R.
Subjects: High Energy Physics - Experiment, Computer Science - Machine Learning, Physics - Instrumentation and Detectors
Abstract: Generative Adversarial Networks trained on samples of simulated or actual events have been proposed as a way of generating large simulated datasets at a reduced computational cost. In this work, a novel approach to perform the simulation of photodetector signals from the time projection chamber of the EXO-200 experiment is demonstrated. The method is based on a Wasserstein Generative Adversarial Network - a deep learning technique allowing for implicit non-parametric estimation of the population distribution for a given set of objects. Our network is trained on real calibration data using raw scintillation waveforms as input. We find that it is able to produce high-quality simulated waveforms an order of magnitude faster than the traditional simulation approach and, importantly, generalize from the training sample and discern salient high-level features of the data. In particular, the network correctly deduces position dependency of scintillation light response in the detector and correctly recognizes dead photodetector channels. The network output is then integrated into the EXO-200 analysis framework to show that the standard EXO-200 reconstruction routine processes the simulated waveforms to produce energy distributions comparable to that of real waveforms. Finally, the remaining discrepancies and potential ways to improve the approach further are highlighted., Comment: As accepted by JINST
Published: 2023
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9. Search for Two-neutrino Double-Beta Decay of $^{136}\rm Xe$ to the $0^+_1$ excited state of $^{136}\rm Ba$ with the Complete EXO-200 Dataset

Author: Collaboration, EXO-200, Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fu, Y. S., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Perna, A., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: A new search for two-neutrino double-beta ($2\nu\beta\beta$) decay of $^{136}\rm Xe$ to the $0^+_1$ excited state of $^{136}\rm Ba$ is performed with the full EXO-200 dataset. A deep learning-based convolutional neural network is used to discriminate signal from background events. Signal detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of two. With the addition of the Phase II dataset taken with an upgraded detector, the median 90$\%$ confidence level half-life sensitivity of $2\nu\beta\beta$ decay to the $0^+_1$ state of $^{136}\rm Ba$ is $2.9 \times 10^{24}~\rm yr$ using a total $^{136}\rm Xe$ exposure of $234.1~\rm kg~yr$. No statistically significant evidence for $2\nu\beta\beta$ decay to the $0^+_1$ state is observed, leading to a lower limit of $T^{2\nu}_{1/2}(0^+ \rightarrow 0^+_1) > 1.4\times10^{24}~\rm yr$ at 90$\%$ confidence level, improved by 70$\%$ relative to the current world's best constraint., Comment: 9 pages, 7 figures, 2 tables
Published: 2023
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10. Nuclear $\beta$ decay as a probe for physics beyond the Standard Model

Author: Brodeur, M., Buzinsky, N., Caprio, M. A., Cirigliano, V., Clark, J. A., Fasano, P. J., Formaggio, J. A., Gallant, A. T., Garcia, A., Gandolfi, S., Gardner, S., Glick-Magid, A., Hayen, L., Hergert, H., Holt, J. D., Horoi, M., Huang, M. Y., Launey, K. D., Leach, K. G., Longfellow, B., Lovato, A., McCoy, A. E., Melconian, D., Mohanmurthy, P., Moore, D. C., Mueller, P., Mereghetti, E., Mittig, W., Navratil, P., Pastore, S., Piarulli, M., Puentes, D., Rasco, B. C., Redshaw, M., Sargsyan, G. H., Savard, G., Scielzo, N. D., Seng, C. -Y., Shindler, A., Stroberg, S. R., Surbrook, J., Walker-Loud, A., Wiringa, R. B., Wrede, C., Young, A. R., and Zelevinsky, V.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: This white paper was submitted to the 2022 Fundamental Symmetries, Neutrons, and Neutrinos (FSNN) Town Hall Meeting in preparation for the next NSAC Long Range Plan. We advocate to support current and future theoretical and experimental searches for physics beyond the Standard Model using nuclear $\beta$ decay., Comment: 12 pages, 2 figures, White paper submitted to the 2022 Fundamental Symmetries, Neutrons, and Neutrinos (FSNN) Town Hall Meeting at the University of North Carolina Chapel Hill
Published: 2023

11. Neutrinoless Double Beta Decay

Author: Adams, C., Alfonso, K., Andreoiu, C., Angelico, E., Arnquist, I. J., Asaadi, J. A. A., Avignone, F. T., Axani, S. N., Barabash, A. S., Barbeau, P. S., Baudis, L., Bellini, F., Beretta, M., Bhatta, T., Biancacci, V., Biassoni, M., Bossio, E., Breur, P. A., Brodsky, J. P., Brofferio, C., Brown, E., Brugnera, R., Brunner, T., Burlac, N., Caden, E., Calgaro, S., Cao, G. F., Cao, L., Capelli, C., Cardani, L., Fernandez, R. Castillo, Cattadori, C. M., Chana, B., Chernyak, D., Christofferson, C. D., Chu, P. -H., Church, E., Cirigliano, V., Collister, R., Comellato, T., Dalmasson, J., D'Andrea, V., Daniels, T., Darroch, L., Decowski, M. P., Demarteau, M., Peixoto, S. De Meireles, Detwiler, J. A., DeVoe, R. G., Di Domizio, S., Di Marco, N., di Vacri, M. L., Dolinski, M. J., Efremenko, Yu., Elbeltagi, M., Elliott, S. R., Engel, J., Fabris, L., Fairbank, W. M., Farine, J., Febbraro, M., Figueroa-Feliciano, E., Fields, D. E., Formaggio, J. A., Foust, B. T., Franke, B., Fu, Y., Fujikawa, B. K., Gallacher, D., Gallina, G., Garfagnini, A., Gingras, C., Gironi, L., Giuliani, A., Gold, M., Gornea, R., Grant, C., Gratta, G., Green, M. P., Grinyer, G. F., Gruszko, J., Guan, Y., Guinn, I. S., Guiseppe, V. E., Gutierrez, T. D., Hansen, E. V., Hardy, C. A., Hauptman, J., Heffner, M., Heeger, K. M., Henning, R., Hergert, H., Aguilar, D. Hervas, Hodak, R., Holt, J. D., Hoppe, E. W., Horoi, M., Huang, H. Z., Inoue, K., Jamil, A., Jochum, J., Jones, B. J. P., Kaizer, J., Karapetrov, G., Kharusi, S. Al, Kidd, M. F., Kishimoto, Y., Klein, J. R., Kolomensky, Yu. G., Kontul, I., Kornoukhov, V. N., Krause, P., Krucken, R., Kumar, K. S., Lang, K., Leach, K. G., Lenardo, B. G., Leonhardt, A., Li, A., Li, G., Li, Z., Licciardi, C., Lindsay, R., Lippi, I., Liu, J., Macko, M., MacLellan, R., Macolino, C., Majidi, S., Mamedov, F., Masbou, J., Massarczyk, R., Mastbaum, A. T., Mayer, D., Mazumdar, A., Mei, D. M., Mei, Y., Meijer, S. J., Mereghetti, E., Mertens, S., Mistry, K., Mitsui, T., Moore, D. C., Morella, M., Nattress, J. T., Neuberger, M., Ngwadla, X. E., Nones, C., Novosad, V., Nygren, D. R., Ondze, J. C. Nzobadila, O'Donnell, T., Gann, G. D. Orebi, Orrell, J. L., Ortega, G. S., Ouellet, J. L., Overman, C., Pagani, L., Palusova, V., Para, A., Pavan, M., Perna, A., Pertoldi, L., Pettus, W., Piepke, A., Piseri, P., Pocar, A., Povinec, P., Psihas, F., Pullia, A., Radford, D. C., Ramonnye, G. J, Rasiwala, H., Redchuk, M., Riboldi, S., Richardson, G., Rielage, K., Rogers, L., Rowson, P. C., Rukhadze, E., Saakyan, R., Sada, C., Salamanna, G., Salamida, F., Saldanha, R., Salvat, D. J., Sangiorgio, S., Schaper, D. C., Schoenert, S., Schwarz, M., Schwartz, S. E., Shitov, Y., Simkovic, F., Singh, V., Slavickova, M., Sousa, A. C., Spadoni, F. L., Speller, D. H., Stekl, I., Sumathi, R. R., Surukuchi, P. T., Tayloe, R., Tornow, W., Torres, J. A., Totev, T. I., Triambak, S., Tyuka, O. A., Vasilyev, S. I., Velazquez, M., Viel, S., Vogl, C., von Strum, K., Wang, Q., Waters, D., Watkins, S. L., Watts, M., Wei, W. -Z., Welliver, B., Wen, Liangjian, Wichoski, U., Wilde, S., Wilkerson, J. F., Winslow, L., Wiseman, C., Wu, X., Xu, W., Yang, H., Yang, L., Yu, C. H., Zeman, J., Zennamo, J., and Zuzel, G.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: This White Paper, prepared for the Fundamental Symmetries, Neutrons, and Neutrinos Town Meeting related to the 2023 Nuclear Physics Long Range Plan, makes the case for double beta decay as a critical component of the future nuclear physics program. The major experimental collaborations and many theorists have endorsed this white paper., Comment: white paper submitted for the Fundamental Symmetries, Neutrons, and Neutrinos Town Meeting in support of the US Nuclear Physics Long Range Planning Process
Published: 2022

12. Acoustic surface modes on metasurfaces with embedded next-nearest neighbor coupling

Author: Moore, D. B., Sambles, J. R., Hibbins, A. P., Starkey, T. A., and Chaplain, G. J.
Subjects: Physics - Applied Physics
Abstract: We design, simulate, and experimentally characterize an acoustic metasurface comprising of a 1D array of open, sound-hard, cavities, modulated with beyond-nearest-neighbor (BNN) couplings in the form of additional connecting cavities embedded beneath the surface. The hidden complex structure is realized readily with additive manufacturing techniques (3D printing). The dispersive properties of the supported localized acoustic surface waves are influenced by competing power-flow channels provided by the BNN couplings, that generate extrema in the dispersion spectra within the first Brillouin zone. The structure supports negatively dispersing 'backwards' waves that we experimentally verify. Such structures thereby provide a route to enhanced acoustic sensing by acoustic metasurfaces., Comment: Main text: 7 pages, 5 figures
Published: 2022
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13. Performance of novel VUV-sensitive Silicon Photo-Multipliers for nEXO

Author: Gallina, G., Guan, Y., Retiere, F., Cao, G., Bolotnikov, A., Kotov, I., Rescia, S., Soma, A. K., Tsang, T., Darroch, L., Brunner, T., Bolster, J., Cohen, J. R., Franco, T. Pinto, Gillis, W. C., Smalley, H. Peltz, Thibado, S., Pocar, A., Bhat, A., Jamil, A., Moore, D. C., Adhikari, G., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Arsenault, P., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Brodsky, J. P., Brown, E., Caden, E., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Collister, R., Cvitan, M., Dalmasson, J., Daniels, T., Deslandes, K., DeVoe, R., di Vacri, M. L., Ding, Y., Dolinski, M. J., Dragone, A., Echevers, J., Eckert, B., Elbeltagi, M., Fabris, L., Fairbank, W., Farine, J., Fu, Y. S., Gallacher, D., Gautam, P., Giacomini, G., Gingras, C., Goeldi, D., Gornea, R., Gratta, G., Hardy, C. A., Hedges, S., Heffner, M., Hein, E., Holt, J., Hoppe, E. W., Hößl, J., House, A., Hunt, W., Iverson, A., Jiang, X. S., Karelin, A., Kaufman, L. J., Krücken, R., Kuchenkov, A., Kumar, K. S., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Lessard, G., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Majidi, S., Malbrunot, C., Margetak, P., Martel-Dion, P., Martin, L., Masbou, J., Massacret, N., McMichael, K., Mong, B., Murray, K., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ondze, J. C. Nzobadila, Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Parent, S., Perna, A., Piepke, A., Pletskova, N., Pratte, J. F., Radeka, V., Raguzin, E., Ramonnye, G. J., Rao, T., Rasiwala, H., Raymond, K., Rebeiro, B. M., Richardson, G., Ringuette, J., Riot, V., Rossignol, T., Rowson, P. C., Rudolph, L., Saldanha, R., Sangiorgio, S., Shang, X., Spadoni, F., Stekhanov, V., Sun, X. L., Tidball, A., Totev, T., Triambak, S., Tsang, R. H. M., Tyuka, O. A., Vachon, F., Vidal, M., Viel, S., Visser, G., Wagenpfeil, M., Walent, M., Wamba, K., Wang, Q., Wang, W., Wang, Y., Watts, M., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Wu, W. H., Wu, X., Xie, L., Yan, W., Yang, H., Yang, L., Zeldovich, O., Zhao, J., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors
Abstract: Liquid xenon time projection chambers are promising detectors to search for neutrinoless double beta decay (0$\nu \beta \beta$), due to their response uniformity, monolithic sensitive volume, scalability to large target masses, and suitability for extremely low background operations. The nEXO collaboration has designed a tonne-scale time projection chamber that aims to search for 0$\nu \beta \beta$ of \ce{^{136}Xe} with projected half-life sensitivity of $1.35\times 10^{28}$~yr. To reach this sensitivity, the design goal for nEXO is $\leq$1\% energy resolution at the decay $Q$-value ($2458.07\pm 0.31$~keV). Reaching this resolution requires the efficient collection of both the ionization and scintillation produced in the detector. The nEXO design employs Silicon Photo-Multipliers (SiPMs) to detect the vacuum ultra-violet, 175 nm scintillation light of liquid xenon. This paper reports on the characterization of the newest vacuum ultra-violet sensitive Fondazione Bruno Kessler VUVHD3 SiPMs specifically designed for nEXO, as well as new measurements on new test samples of previously characterised Hamamatsu VUV4 Multi Pixel Photon Counters (MPPCs). Various SiPM and MPPC parameters, such as dark noise, gain, direct crosstalk, correlated avalanches and photon detection efficiency were measured as a function of the applied over voltage and wavelength at liquid xenon temperature (163~K). The results from this study are used to provide updated estimates of the achievable energy resolution at the decay $Q$-value for the nEXO design.
Published: 2022
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14. Understanding the Service Needs and Preferences of Men Who Have Sex with Men Who Use Crystal Methamphetamine in British Columbia, Canada: a Qualitative Study

Author: Fulcher, K., Berlin, G., Taylor, K., Wells, A., Nguyen, T., Moore, D., Hull, M., and Lachowsky, N. J.
Published: 2023
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15. Search for MeV Electron Recoils from Dark Matter in EXO-200

Author: Collaboration, EXO-200, Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fu, Y. S., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Perna, A., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Ruddell, D., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., Tsang, R. H. M., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: We present a search for electron-recoil signatures from the charged-current absorption of fermionic dark matter using the EXO-200 detector. We report an average electron recoil background rate of $6.8 \times 10^{-4}\, \mathrm{cts}\,\mathrm{kg}^{-1}\mathrm{yr}^{-1}\mathrm{keV}^{-1}$ above $4\,\mathrm{MeV}$ and find no statistically significant excess over our background projection. Using a total ${}^{136}\mathrm{Xe}$ exposure of $234.1\,\mathrm{kg}\,\mathrm{yr}$ we exclude new parameter space for the charged-current absorption cross-section for dark matter masses between $m_\chi = 2.6\,\mathrm{MeV} - 11.6\,\mathrm{MeV}$ with a minimum of $6\times 10^{-51}\,\mathrm{cm}^2$ at $8.3\,\mathrm{MeV}$ at the $90\%$ confidence level., Comment: 9 pages, 6 figures, 1 table
Published: 2022
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16. Socioeconomic Deprivation Correlates With Incomplete Radiotherapy Treatment in Head and Neck Cancer

Author: Brooker, R., Parvulescu, P., Jones, L., Meysner, S., Moore, D., Dailey, Y., Haridass, A., Davies, K., Schache, A., Shaw, R., and Jones, T.
Published: 2025
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17. Development of a $^{127}$Xe calibration source for nEXO

Author: Lenardo, B. G., Hardy, C. A., Tsang, R. H. M., Ondze, J. C. Nzobadila, Piepke, A., Triambak, S., Jamil, A., Adhikari, G., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Belov, V., Bernard, E. P., Bhat, A., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cohen, J. R., Collister, R., Dalmasson, J., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Ding, Y. Y., Dolinski, M. J., Echevers, J., Eckert, B., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Fu, Y. S., Gallina, G., Gautam, P., Giacomini, G., Gillis, W., Gingras, C., Gornea, R., Gratta, G., Harouaka, K., Heffner, M., Hein, E., Hößl, J., House, A., Iverson, A., Jiang, X. S., Karelin, A., Kaufman, L. J., Krücken, R., Kuchenkov, A., Kumar, K. S., Larson, A., Leach, K. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Masbou, J., McMichael, K., Peregrina, M. Medina, Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ni, K., Ning, Z., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Perna, A., Franco, T. Pinto, Pocar, A., Pratte, J. F., Priel, N., Raguzin, E., Ramonnye, G. J., Rasiwala, H., Raymond, K., Richardson, G., Richman, M., Ringuette, J., Rowson, P. C., Saldanha, R., Sangiorgio, S., Shang, X., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Thibado, S., Tidball, A., Todd, J., Totev, T., Tyuka, O. A., Vachon, F., Veeraraghavan, V., Viel, S., Wamba, K., Wang, Y., Wang, Q., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Wu, W. H., Yan, W., Yang, L., Zeldovich, O., Zhao, J., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: We study a possible calibration technique for the nEXO experiment using a $^{127}$Xe electron capture source. nEXO is a next-generation search for neutrinoless double beta decay ($0\nu\beta\beta$) that will use a 5-tonne, monolithic liquid xenon time projection chamber (TPC). The xenon, used both as source and detection medium, will be enriched to 90% in $^{136}$Xe. To optimize the event reconstruction and energy resolution, calibrations are needed to map the position- and time-dependent detector response. The 36.3 day half-life of $^{127}$Xe and its small $Q$-value compared to that of $^{136}$Xe $0\nu\beta\beta$ would allow a small activity to be maintained continuously in the detector during normal operations without introducing additional backgrounds, thereby enabling in-situ calibration and monitoring of the detector response. In this work we describe a process for producing the source and preliminary experimental tests. We then use simulations to project the precision with which such a source could calibrate spatial corrections to the light and charge response of the nEXO TPC., Comment: 24 pages, 16 figures
Published: 2022
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18. Kiloton-scale xenon detectors for neutrinoless double beta decay and other new physics searches

Author: Avasthi, A., Bowyer, T. W., Bray, C., Brunner, T., Catarineu, N., Church, E., Guenette, R., Haselschwardt, S. J., Hayes, J. C., Heffner, M., Hertel, S. A., Humble, P. H., Jamil, A., Kim, S., Lang, R. F., Leach, K. G., Lenardo, B. G., Lippincott, W. H., Marino, A., McKinsey, D. N., Miller, E. H., Moore, D. C., Mong, B., Monreal, B., Monzani, M. E., Olcina, I., Orrell, J. L., Pang, S., Pocar, A., Rowson, P. C., Saldanha, R., Sangiorgio, S., Stanford, C., and Visser, A.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract: Large detectors employing xenon are a leading technology in existing and planned searches for new physics, including searches for neutrinoless double beta decay ($0\nu\beta\beta$) and dark matter. While upcoming detectors will employ target masses of a ton or more, further extending gas or liquid phase Xe detectors to the kton scale would enable extremely sensitive next-generation searches for rare phenomena. The key challenge to extending this technology to detectors well beyond the ton scale is the acquisition of the Xe itself. We describe the motivation for extending Xe time projection chambers (TPCs) to the kton scale and possible avenues for Xe acquisition that avoid existing supply chains. If acquisition of Xe in the required quantities is successful, kton-scale detectors of this type could enable a new generation of experiments, including searches for $0\nu\beta\beta$ at half-life sensitivities as long as $10^{30}$ yr., Comment: 19 pages, 10 figures; published version
Published: 2021
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19. Search for Majoron-emitting modes of $^{136}$Xe double beta decay with the complete EXO-200 dataset

Author: Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krucken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Perna, A., Piepke, A., Pocar, A., Retiere, F., Robinson, A. L., Rowson, P. C., Rudde, D., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: A search for Majoron-emitting modes of the neutrinoless double-beta decay of $^{136}$Xe is performed with the full EXO-200 dataset. This dataset consists of a total $^{136}$Xe exposure of 234.1 kg$\cdot$yr, and includes data with detector upgrades that have improved the energy threshold relative to previous searches. A lower limit of T$_{1/2}^{\rm{^{136}Xe}}>$4.3$\cdot$10$^{24}$ yr at 90\% C.L. on the half-life of the spectral index $n=1$ Majoron decay was obtained, a factor of 3.6 more stringent than the previous limit from EXO-200, corresponding to a constraint on the Majoron-neutrino coupling constant of $|\langle g_{ee}^{M}\rangle|$$<(0.4$-$0.9)\cdot10^{-5}$. The lower threshold and the additional data taken resulted in a factor 8.4 improvement for the $n=7$ mode compared to the previous EXO search. This search provides the most stringent limits to-date on the Majoron-emitting decays of $^{136}$Xe with spectral indices $n=1,2,3,$ and 7.
Published: 2021
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20. The EXO-200 detector, part II: Auxiliary Systems

Author: Ackerman, N., Albert, J., Auger, M., Auty, D. J., Badhrees, I., Barbeau, P. S., Bartoszek, L., Baussan, E., Belov, V., Benitez-Medina, C., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Conley, R., Cook, S., Coon, M., Craddock, W., Craycraft, A., Cree, W., Daniels, T., Darroch, L., Daugherty, S. J., Daughhetee, J., Davis, C. G., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., deVoe, R., Didberidze, T., Dilling, J., Dobi, A., Dolgolenko, A. G., Dolinski, M. J., Dunford, M., Echevers, J., Espic, L., Fairbank Jr., W., Fairbank, D., Farine, J., Feldmeier, W., Feyzbakhsh, S., Fierlinger, P., Fouts, K., Franco, D., Freytag, D., Fudenberg, D., Gautam, P., Giroux, G., Gornea, R., Graham, K., Gratta, G., Hagemann, C., Hall, C., Hall, K., Haller, G., Hansen, E. V., Hargrove, C., Herbst, R., Herrin, S., Hodgson, J., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Johnson, T. N., Johnston, S., Karelin, A., Kaufman, L. J., Killick, R., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leonard, D. S., Leonard, F., LePort, F., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., Mackay, D., MacLellan, R., Marino, M., Martin, J. -M., Martin, Y., McElroy, T., McFarlane, K., Michel, T., Mong, B., Moore, D. C., Murray, K., Neilson, R., Njoya, O., Nusair, O., O'Sullivan, K., Odian, A., Ostrovskiy, I., Ouellet, C., Piepke, A., Pocar, A., Prescott, C. Y., Pushkin, K., Retiere, F., Rivas, A., Robinson, A. L., Rollin, E., Rowson, P. C., Rozo, M. P., Runge, J., Russell, J. J., Schmidt, S., Schubert, A., Sinclair, D., Skarpaas, K., Slutsky, S., Smith, E., Soma, A. K., Stekhanov, V., Strickland, V., Swift, M., Tarka, M., Todd, J., Tolba, T., Tosi, D., Totev, T. I., Tsang, R., Twelker, K., Veenstra, B., Veeraraghavan, V., Vuilleumier, J. -L., Vuilleumier, J. -M., Wagenpfeil, M., Waite, A., Walton, J., Walton, T., Wamba, K., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wittgen, M., Wodin, J., Wood, J., Wrede, G., Wu, S. X., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O. Ya, and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract: The EXO-200 experiment searched for neutrinoless double-beta decay of $^{136}$Xe with a single-phase liquid xenon detector. It used an active mass of 110 kg of 80.6%-enriched liquid xenon in an ultra-low background time projection chamber with ionization and scintillation detection and readout. This paper describes the design and performance of the various support systems necessary for detector operation, including cryogenics, xenon handling, and controls. Novel features of the system were driven by the need to protect the thin-walled detector chamber containing the liquid xenon, to achieve high chemical purity of the Xe, and to maintain thermal uniformity across the detector., Comment: Manuscript updated in response to JINST reviewer comments
Published: 2021
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21. NEXO: Neutrinoless double beta decay search beyond $10^{28}$ year half-life sensitivity

Author: nEXO Collaboration, Adhikari, G., Kharusi, S. Al, Angelico, E., Anton, G., Arnquist, I. J., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Collister, R., Czyz, S. A., Dalmasson, J., Daniels, T., Darroch, L., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolgolenko, A., Dolinski, M. J., Dragone, A., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fu, Y. S., Gallina, G., Gautam, P., Giacomini, G., Gingras, W. Gillis C., Goeldi, D., Gornea, R., Gratta, G., Hardy, C. A., Harouaka, K., Heffner, M., Hoppe, E. W., House, A., Iverson, A., Jamil, A., Jewell, M., Jiang, X. S., Karelin, A., Kaufman, L. J., Kotov, I., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Mahtab, M., Martel-Dion, P., Masbou, J., Massacret, N., McElroy, T., McMichael, K., Peregrina, M. Medina, Michel, T., Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Newby, R. J., Ni, K., Nolet, F., Nusair, O., Ondze, J. C. Nzobadila, Odgers, K., Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Parent, S., Perna, A., Piepke, A., Pocar, A., Pratte, J-F., Priel, N., Radeka, V., Raguzin, E., Ramonnye, G. J., Rao, T., Rasiwala, H., Rescia, S., Retière, F., Ringuette, J., Riot, V., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Shang, X., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Tarka, M., Thibado, S., Tidball, A., Todd, J., Totev, T., Triambak, S., Tsang, R. H. M., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Vivo-Vilches, C., Vogel, P., Vuilleumier, J-L., Wagenpfeil, M., Wager, T., Walent, M., Wamba, K., Wang, Q., Wei, W., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yan, W., Yang, H., Yang, L., Zeldovich, O., Zhao, J., and Ziegler, T.
Subjects: Nuclear Experiment, Physics - Instrumentation and Detectors
Abstract: The nEXO neutrinoless double beta decay experiment is designed to use a time projection chamber and 5000 kg of isotopically enriched liquid xenon to search for the decay in $^{136}$Xe. Progress in the detector design, paired with higher fidelity in its simulation and an advanced data analysis, based on the one used for the final results of EXO-200, produce a sensitivity prediction that exceeds the half-life of $10^{28}$ years. Specifically, improvements have been made in the understanding of production of scintillation photons and charge as well as of their transport and reconstruction in the detector. The more detailed knowledge of the detector construction has been paired with more assays for trace radioactivity in different materials. In particular, the use of custom electroformed copper is now incorporated in the design, leading to a substantial reduction in backgrounds from the intrinsic radioactivity of detector materials. Furthermore, a number of assumptions from previous sensitivity projections have gained further support from interim work validating the nEXO experiment concept. Together these improvements and updates suggest that the nEXO experiment will reach a half-life sensitivity of $1.35\times 10^{28}$ yr at 90% confidence level in 10 years of data taking, covering the parameter space associated with the inverted neutrino mass ordering, along with a significant portion of the parameter space for the normal ordering scenario, for almost all nuclear matrix elements. The effects of backgrounds deviating from the nominal values used for the projections are also illustrated, concluding that the nEXO design is robust against a number of imperfections of the model., Comment: 26 pages, 19 figures, version accepted by Journal of Phys. G
Published: 2021
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22. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial

Author: Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, 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P, Wubetu, J, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, B, Xia, Z, Y Ellis, T, Yacoba, E, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, W, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, M, Yates, T, Ye, J, Yearwood Martin, C, Yein, K, Yeoh, A, Yeung, C, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yu, C, Yuan, J, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-M, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, E, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
Published: 2024
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23. Reflectivity of VUV-sensitive Silicon Photomultipliers in Liquid Xenon

Author: Wagenpfeil, M., Ziegler, T., Schneider, J., Fieguth, A., Murra, M., Schulte, D., Althueser, L., Huhmann, C., Weinheimer, C., Michel, T., Anton, G., Adhikari, G., Kharusi, S. Al, Angelico, E., Arnquist, I. J., Badhrees, I., Bane, J., Beck, D., Belov, V., Bhatta, T., Bolotnikov, A., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Chambers, C., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Cleveland, B., Craycraft, A., Daniels, T., Darroch, L., Der Mesrobian-Kabakian, A., Croix, A. de St, Deslandes, K., DeVoe, R., Di Vacri, M. L., Dolinski, M. J., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Gallina, G., Gautam, P., Giacomini, G., Gingras, C., Goeldi, D., Gorham, A., Gornea, R., Gratta, G., Hansen, E. V., Hardy, C. A., Harouaka, K., Heffner, M., Hoppe, E. W., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M., Karelin, A., Kaufman, L. J., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Martel-Dion, P., Massacret, N., McElroy, T., Peregrina, M. Medina, Mong, B., Moore, D. C., Murray, K., Nattress, J., Natzke, C. R., Newby, R. J., Nolet, F., Nusair, O., Ondze, J. C. Nzobadila, Odgers, K., Odian, A., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Raguzin, E., Ramonnye, G. J., Rasiwala, H., Rescia, S., Retière, F., Richard, C., Richman, M., Ringuette, J., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Soma, A. K., Spadoni, F., Stekhanov, V., Stiegler, T., Tarka, M., Thibado, S., Tidball, A., Todd, J., Totev, T., Triambak, S., Tsang, R., Vachon, F., Veeraraghavan, V., Viel, S., Vivo-Vilches, C., Walent, M., Wichoski, U., Worcester, M., Wu, S. X., Xia, Q., Yan, W., Yang, L., and Zeldovich, O.
Subjects: Physics - Instrumentation and Detectors
Abstract: Silicon photomultipliers are regarded as a very promising technology for next-generation, cutting-edge detectors for low-background experiments in particle physics. This work presents systematic reflectivity studies of Silicon Photomultipliers (SiPM) and other samples in liquid xenon at vacuum ultraviolet (VUV) wavelengths. A dedicated setup at the University of M\"unster has been used that allows to acquire angle-resolved reflection measurements of various samples immersed in liquid xenon with 0.45{\deg} angular resolution. Four samples are investigated in this work: one Hamamatsu VUV4 SiPM, one FBK VUV-HD SiPM, one FBK wafer sample and one Large-Area Avalanche Photodiode (LA-APD) from EXO-200. The reflectivity is determined to be 25-36% at an angle of incidence of 20{\deg} for the four samples and increases to up to 65% at 70{\deg} for the LA-APD and the FBK samples. The Hamamatsu VUV4 SiPM shows a decline with increasing angle of incidence. The reflectivity results will be incorporated in upcoming light response simulations of the nEXO detector., Comment: 18 pages, 11 figures
Published: 2021
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24. Efficacy of a novel β-mannanase on intestinal digesta viscosity in broiler chickens fed diets with high levels of guar meal (Cyamopsis tetragonoloba)

Author: Fickler, A., Kore, K., Matthews, A., Moore, D., and Mandal, A.B.
Published: 2023
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25. Classification of variants of reduced penetrance in high-penetrance cancer susceptibility genes: Framework for genetics clinicians and clinical scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

Author: Turnbull, C., Garrett, A., Loong, L., Choi, S., Torr, B., Allen, S., Durkie, M., Callaway, A., Drummond, J., Burghel, G.J., Robinson, R., Berry, I.R., Wallace, A.J., Eccles, D.M., Tischkowitz, M., Ellard, S., Hanson, H., Baple, E., Evans, D.G., Woodward, E., Lalloo, F., Samant, S., Lucassen, A., Znaczko, A., Shaw, A., Ansari, A., Kumar, A., Donaldson, A., Murray, A., Ross, A., Taylor-Beadling, A., Taylor, A., Innes, A., Brady, A., Kulkarni, A., Hogg, A.C., Bowden, A. Ramsay, Hadonou, A., Coad, B., McIldowie, B., Speight, B., DeSouza, B., Mullaney, B., McKenna, C., Brewer, C., Olimpio, C., Clabby, C., Crosby, C., Jenkins, C., Armstrong, C., Bowles, C., Brooks, C., Byrne, C., Maurer, C., Baralle, D., Chubb, D., Stobo, D., Moore, D., O'Sullivan, D., Donnelly, D., Randhawa, D., Halliday, D., Atkinson, E., Rauter, E., Johnston, E., Maher, E., Sofianopoulou, E., Petrides, E., McRonald, F., Pelz, F., Frayling, I., Corbett, G., Rea, G., Clouston, H., Powell, H., Williamson, H., Carley, H., Thomas, H.J.W., Tomlinson, I., Cook, J., Hoyle, J., Tellez, J., Whitworth, J., Williams, J., Murray, J., Campbell, J., Tolmie, J., Field, J., Mason, J., Burn, J., Bruty, J., Callaway, J., Grant, J., Del Rey Jimenez, J., Pagan, J., VanCampen, J., Barwell, J., Monahan, K., Tatton-Brown, K., Ong, K.R., Murphy, K., Andrews, K., Mokretar, K., Cadoo, K., Smith, K., Baker, K., Brown, K., Reay, K., McKay Bounford, K., Bradshaw, K., Russell, K., Stone, K., Snape, K., Crookes, L., Reed, L., Taggart, L., Yarram, L., Cobbold, L., Walker, L., Hawkes, L., Busby, L., Izatt, L., Kiely, L., Hughes, L., Side, L., Sarkies, L., Greenhalgh, K.-L., Shanmugasundaram, M., Duff, M., Bartlett, M., Watson, M., Owens, M., Bradford, M., Huxley, M., Slean, M., Ryten, M., Smith, M., Ahmed, M., Roberts, N., O'Brien, C., Middleton, O., Tarpey, P., Logan, P., Dean, P., May, P., Brace, P., Tredwell, R., Harrison, R., Hart, R., Kirk, R., Martin, R., Nyanhete, R., Wright, R., Davidson, R., Cleaver, R., Talukdar, S., Butler, S., Sampson, J., Ribeiro, S., Dell, S., Mackenzie, S., Hegarty, S., Albaba, S., McKee, S., Palmer-Smith, S., Heggarty, S., MacParland, S., Greville-Heygate, S., Daniels, S., Prapa, S., Abbs, S., Tennant, S., Hardy, S., MacMahon, S., McVeigh, T., Foo, T., Bedenham, T., Cranston, T., McDevitt, T., Clowes, V., Tripathi, V., McConnell, V., Woodwaer, N., Wallis, Y., Kemp, Z., Mullan, G., Pierson, L., Rainey, L., Joyce, C., Timbs, A., Reuther, A.-M., Frugtniet, B., Husher, C., Lawn, C., Corbett, C., Nocera-Jijon, D., Reay, D., Cross, E., Ryan, F., Lindsay, H., Oliver, J., Dring, J., Spiers, J., Harper, J., Ciucias, K., Connolly, L., Tsang, M., Brown, R., Shepherd, S., Begum, S., Tadiso, T., Linton-Willoughby, T., Heppell, H., Sahan, K., Worrillow, L., Allen, Z., Watt, C., Hegarty, M., Mitchell, R., Coles, R., Nickless, G., Cojocaru, E., Doal, I., Sava, F., McCarthy, C., Jeeneea, R., Goudie, D., McConachie, M., Botosneanu, S., Kavanaugh, G., Sherlaw, C., Tsoulaki, O., Forde, C., Petley, E., Jones, A.-B., Oprych, K., Pryde, S., Hyder, Z., Elkhateeb, N., Braham, R., Hanington, L., Huntley, C., Irving, R., Sadan, A., Ramos, M., Elliot, C., Wren, D., Lobo, D., McLean, J., May, D., Kearney, L., Campbell, T., Asakura, K., Alwadi, L., O’Shea, R., Gabriel, J., Chiecchio, L., Bowman, P., Sutton, L.A., Walsh, C., Cloke, V., Ucanok, D., Davies, J., Pleasance, B., Maguire, E., Whaite, A., Best, S., Westbury, S., Logan, A., Navarajasegaran, D., Bench, A., Wightman, P., Cartwright, A., Higgs, E., J.Bott, Whitehouse, H., Stevens, J., Martin, D., Dunlop, J., Thomas, S., Sau, C., Farndon, S., Coleman, N., Angelini, P., Massey, H., Rowlands, C., Garcia-Petit, C., Gillespie, K., Alder, A., Middleton, E., Cassidy, C., Orfali, N., Webb, A., Luharia, A., Walker, N., Charlton, J., Andreou, A., Peddie, J., Khan, M., Wilkinson, L., Bezuidenhout, H., Edis, M., Callard, A., Ostrowski, P., Moverley, P., Bean, K., Dunne, A., Moleirinho, A., Waller, S., Cox, K., Greensmith, L., Brittle, A., Gossan, N., Freestone, L., Shak, C., Langford, T., Clinch, Y., Livesey, H., Borland, S., Joshi, A., Wall, K., Whitworth, A., Wilsdon, A., Edgerley, K., Pugh, S., Chrysochoidi, N., Mutch, S., McMullan, C., Johnston, Y., Muraru, M., May, A., Begum, R., Smith, C., Patel, R., Bhatnagar, I., Brown, D., Willan, J., Taylor, S., Jones, K., Ramsden, C., Taiwo, O., Jaudzemaite, J., Sharmin, R., Young, L., C.O’Dubhshlaine, McSorley, L., Rodriguez, I. Abreu, Lillis, S., Alexopoulos, P., Mortensson, E., Kingham, L., Moore, R., Kosicka-Slawinska, M., Aslam, S., Wells, R., Carter, A., Warren, H., Rolf, E., Reed, H., Pearce, L., Lock, D., Ali, F., Kolozi, A., White, N., Wood, D., Hayden, C., Garrett, Alice, Allen, Sophie, Durkie, Miranda, Burghel, George J., Robinson, Rachel, Callaway, Alison, Field, Joanne, Frugtniet, Bethan, Palmer-Smith, Sheila, Grant, Jonathan, Pagan, Judith, McDevitt, Trudi, Rowlands, Charlie F., McVeigh, Terri, Hanson, Helen, and Turnbull, Clare
Published: 2024
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26. Event Reconstruction in a Liquid Xenon Time Projection Chamber with an Optically-Open Field Cage

Author: Stiegler, T., Sangiorgio, S., Brodsky, J. P., Heffner, M., Kharusi, S. Al, Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Bolotnikov, A., Breur, P. A., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Croix, A. De St., Der Mesrobian-Kabakian, A., Deslandes, K., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Edaltafar, F., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Hoppe, E. W., Hößl, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lv, P., MacLellan, R., Massacret, N., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Natzke, C. R., Newby, R. J., Ni, K., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Retière, F., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Sun, X. L., Tarka, M., Thibado, S., Tidball, A., Todd, J., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Wager, T., Walent, M., Wang, Q., Wei, W., Wen, L. J., Wichoski, U., Worcester, M., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors
Abstract: nEXO is a proposed tonne-scale neutrinoless double beta decay ($0\nu\beta\beta$) experiment using liquid ${}^{136}Xe$ (LXe) in a Time Projection Chamber (TPC) to read out ionization and scintillation signals. Between the field cage and the LXe vessel, a layer of LXe ("skin" LXe) is present, where no ionization signal is collected. Only scintillation photons are detected, owing to the lack of optical barrier around the field cage. In this work, we show that the light originating in the skin LXe region can be used to improve background discrimination by 5% over previous published estimates. This improvement comes from two elements. First, a fraction of the $\gamma$-ray background is removed by identifying light from interactions with an energy deposition in the skin LXe. Second, background from ${}^{222}Rn$ dissolved in the skin LXe can be efficiently rejected by tagging the $\alpha$ decay in the ${}^{214}Bi-{}^{214}Po$ chain in the skin LXe., Comment: 11 pages, 12 figures
Published: 2020
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27. Measurement of the Spectral Shape of the beta-decay of 137Xe to the Ground State of 137Cs in EXO-200 and Comparison with Theory

Author: Kharusi, S. Al, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Kostensalo, J., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Ruddell, D., Runge, J., Schmidt, S., Sinclair, D., Skarpaas, K., Soma, A. K., Stekhanov, V., Suhonen, J., Tarka, M., Thibado, S., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: We report on a comparison between the theoretically predicted and experimentally measured spectra of the first-forbidden non-unique $\beta$-decay transition $^{137}\textrm{Xe}(7/2^-)\to\,^{137}\textrm{Cs}(7/2^+)$. The experimental data were acquired by the EXO-200 experiment during a deployment of an AmBe neutron source. The ultra-low background environment of EXO-200, together with dedicated source deployment and analysis procedures, allowed for collection of a pure sample of the decays, with an estimated signal-to-background ratio of more than 99-to-1 in the energy range from 1075 to 4175 keV. In addition to providing a rare and accurate measurement of the first-forbidden non-unique $\beta$-decay shape, this work constitutes a novel test of the calculated electron spectral shapes in the context of the reactor antineutrino anomaly and spectral bump., Comment: Version as accepted by PRL
Published: 2020
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28. Reflectance of Silicon Photomultipliers at Vacuum Ultraviolet Wavelengths

Author: Lv, P., Cao, G. F., Wen, L. J., Kharusi, S. Al, Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Mamahit, S. Byrne, Caden, E., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Croix, A. De St., Der Mesrobian-Kabakian, A., Deslandes, K., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Doria, L., Dragone, A., Echevers, J., Edaltafar, F., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fucarino, A., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., MacLellan, R., Massacret, N., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Natzke, C. R., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Retière, F., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Wager, T., Walent, M., Wang, Q., Watkins, J., Wei, W., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Characterization of the vacuum ultraviolet (VUV) reflectance of silicon photomultipliers (SiPMs) is important for large-scale SiPM-based photodetector systems. We report the angular dependence of the specular reflectance in a vacuum of SiPMs manufactured by Fondazionc Bruno Kessler (FBK) and Hamamatsu Photonics K.K. (HPK) over wavelengths ranging from 120 nm to 280 nm. Refractive index and extinction coefficient of the thin silicon-dioxide film deposited on the surface of the FBK SiPMs are derived from reflectance data of a FBK silicon wafer with the same deposited oxide film as SiPMs. The diffuse reflectance of SiPMs is also measured at 193 nm. We use the VUV spectral dependence of the optical constants to predict the reflectance of the FBK silicon wafer and FBK SiPMs in liquid xenon.
Published: 2019
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29. Measurements of electron transport in liquid and gas Xenon using a laser-driven photocathode

Author: Njoya, O., Tsang, T., Tarka, M., Fairbank, W., Kumar, K. S., Rao, T., Wager, T., Kharusi, S. Al, Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Croix, A. De St., Der Mesrobian-Kabakian, A., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Farine, J., Ferrara, S., Feyzbakhsh, S., Fontaine, R., Fucarino, A., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hossl, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Krucken, R., Kuchenkov, A., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., Lv, P., MacLellan, R., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Natzke, C. R., Newby, R. J., Ning, Z., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Retiere, F., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Walent, M., Wang, Q., Ward, M., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Yen, Y. -R., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: Measurements of electron drift properties in liquid and gaseous xenon are reported. The electrons are generated by the photoelectric effect in a semi-transparent gold photocathode driven in transmission mode with a pulsed ultraviolet laser. The charges drift and diffuse in a small chamber at various electric fields and a fixed drift distance of 2.0 cm. At an electric field of 0.5 kV/cm, the measured drift velocities and corresponding temperature coefficients respectively are $1.97 \pm 0.04$ mm/$\mu$s and $(-0.69\pm0.05)$\%/K for liquid xenon, and $1.42 \pm 0.03$ mm/$\mu$s and $(+0.11\pm0.01)$\%/K for gaseous xenon at 1.5 bar. In addition, we measure longitudinal diffusion coefficients of $25.7 \pm 4.6$ cm$^2$/s and $149 \pm 23$ cm$^2$/s, for liquid and gas, respectively. The quantum efficiency of the gold photocathode is studied at the photon energy of 4.73 eV in liquid and gaseous xenon, and vacuum. These charge transport properties and the behavior of photocathodes in a xenon environment are important in designing and calibrating future large scale noble liquid detectors.
Published: 2019
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30. Reflectivity and PDE of VUV4 Hamamatsu SiPMs in Liquid Xenon

Author: Nakarmi, P., Ostrovskiy, I., Soma, A. K., Retiere, F., Kharusi, S. Al, Alfaris, M., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Blatchford, J., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Mamahit, S. Byrne, Caden, E., Cao, G. F., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Croix, A. De St., Der Mesrobian-Kabakian, A., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Doria, L., Dragone, A., Echevers, J., Edaltafar, F., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fontaine, R., Fucarino, A., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hößle, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lv, P., MacLellan, R., Massacret, N., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Natzke, C. R., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, l J. L., Ortega, G. S., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, St-Hilaire, G., Stekhanov, r V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Wager, T., Walent, M., Wang, Q., Ward, M., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Understanding reflective properties of materials and photodetection efficiency (PDE) of photodetectors is important for optimizing energy resolution and sensitivity of the next generation neutrinoless double beta decay, direct detection dark matter, and neutrino oscillation experiments that will use noble liquid gases, such as nEXO, DARWIN, DarkSide-20k, and DUNE. Little information is currently available about reflectivity and PDE in liquid noble gases, because such measurements are difficult to conduct in a cryogenic environment and at short enough wavelengths. Here we report a measurement of specular reflectivity and relative PDE of Hamamatsu VUV4 silicon photomultipliers (SiPMs) with 50 micrometer micro-cells conducted with xenon scintillation light (~175 nm) in liquid xenon. The specular reflectivity at 15 deg. incidence of three samples of VUV4 SiPMs is found to be 30.4+/-1.4%, 28.6+/-1.3%, and 28.0+/-1.3%, respectively. The PDE at normal incidence differs by +/-8% (standard deviation) among the three devices. The angular dependence of the reflectivity and PDE was also measured for one of the SiPMs. Both the reflectivity and PDE decrease as the angle of incidence increases. This is the first measurement of an angular dependence of PDE and reflectivity of a SiPM in liquid xenon., Comment: 21 pages, 15 figures, 6 tables. As accepted by JINST
Published: 2019
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31. Measurement of the scintillation and ionization response of liquid xenon at MeV energies in the EXO-200 experiment

Author: Collaboration, EXO-200, Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krucken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Neilson, R., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retiere, F., Robinson, A. L., Rowson, P. C., Runge, J., Schmidt, S., Sinclair, D., Soma, A. K., Stekhanov, V., Tarka, M., Todd, J., Tolba, T., Tosi, D., Totev, T. I., Veenstra, B., Veeraraghavan, V., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegle, T.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Liquid xenon (LXe) is employed in a number of current and future detectors for rare event searches. We use the EXO-200 experimental data to measure the absolute scintillation and ionization yields generated by $\gamma$ interactions from $^{228}$Th (2615~keV), $^{226}$Ra (1764~keV) and $^{60}$Co (1332~keV and 1173~keV) calibration sources, over a range of electric fields. The $W$-value that defines the recombination-independent energy scale is measured to be $11.5~\pm~0.5$~(syst.)~$\pm~0.1$~(stat.) eV. These data are also used to measure the recombination fluctuations in the number of electrons and photons produced by the calibration sources at the MeV-scale, which deviate from extrapolations of lower-energy data. Additionally, a semi-empirical model for the energy resolution of the detector is developed, which is used to constrain the recombination efficiency, i.e., the fraction of recombined electrons that result in the emission of a detectable photon. Detailed measurements of the absolute charge and light yields for MeV-scale electron recoils are important for predicting the performance of future neutrinoless double beta decay detectors.
Published: 2019
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32. Simulation of charge readout with segmented tiles in nEXO

Author: Li, Z., Cen, W. R., Robinson, A., Moore, D. C., Wen, L. J., Odian, A., Kharusi, S. Al, Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L., Chambers, C., Chana, B., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Croix, A. De St., Der Mesrobian-Kabakian, A., DeVoe, R., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fontaine, R., Fucarino, A., Gallina, G., Gautam, P., Giacomini, G., Goeldi, D., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hughes, M., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leach, K. G., Lenardo, B. G., Leonard, D. S., Li, G., Li, S., Licciardi, C., Lin, Y. H., Lv, P., MacLellan, R., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Murray, K., Nakarmi, P., Natzke, C. R., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Radeka, V., Raguzin, E., Rescia, S., Retière, F., Richman, M., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Viel, S., Visser, G., Vivo-Vilches, C., Vuilleumier, J. -L., Wagenpfeil, M., Walent, M., Wang, Q., Ward, M., Watkins, J., Weber, M., Wei, W., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Yen, Y. -R., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: nEXO is a proposed experiment to search for the neutrino-less double beta decay ($0\nu\beta\beta$) of $^{136}$Xe in a tonne-scale liquid xenon time projection chamber (TPC). The nEXO TPC will be equipped with charge collection tiles to form the anode. In this work, the charge reconstruction performance of this anode design is studied with a dedicated simulation package. A multi-variate method and a deep neural network are developed to distinguish simulated $0\nu\beta\beta$ signals from backgrounds arising from trace levels of natural radioactivity in the detector materials. These simulations indicate that the nEXO TPC with charge-collection tiles shows promising capability to discriminate the $0\nu\beta\beta$ signal from backgrounds. The estimated half-life sensitivity for $0\nu\beta\beta$ decay is improved by $\sim$20$~(32)\%$ with the multi-variate~(deep neural network) methods considered here, relative to the sensitivity estimated in the nEXO pre-conceptual design report.
Published: 2019
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33. Search for Neutrinoless Double-Beta Decay with the Complete EXO-200 Dataset

Author: Anton, G., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Daniels, T., Danilov, M., Darroch, L., Daugherty, S. J., Davis, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Echevers, J., Fairbank Jr., W., Fairbank, D., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gautam, P., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Johnson, A., Karelin, A., Kaufman, L. J., Koffas, T., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Li, G. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., McElroy, T., Michel, T., Mong, B., Moore, D. C., Murray, K., Njoya, O., Nusair, O., Odian, A., Ostrovskiy, I., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Ruddell, D., Runge, J., Schmidt, S., Sinclair, D., Soma, A. K., Stekhanov, V., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Veenstra, B., Veeraraghavan, V., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Watkins, J., Weber, M., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Xia, Q., Yahne, D. R., Yang, L., Yen, Y. -R., Zeldovich, O. Ya., and Ziegler, T.
Subjects: High Energy Physics - Experiment, Nuclear Experiment
Abstract: A search for neutrinoless double-beta decay ($0\nu\beta\beta$) in $^{136}$Xe is performed with the full EXO-200 dataset using a deep neural network to discriminate between $0\nu\beta\beta$ and background events. Relative to previous analyses, the signal detection efficiency has been raised from 80.8% to 96.4$\pm$3.0% and the energy resolution of the detector at the Q-value of $^{136}$Xe $0\nu\beta\beta$ has been improved from $\sigma/E=1.23\%$ to $1.15\pm0.02\%$ with the upgraded detector. Accounting for the new data, the median 90% confidence level $0\nu\beta\beta$ half-life sensitivity for this analysis is $5.0 \cdot 10^{25}$ yr with a total $^{136}$Xe exposure of 234.1 kg$\cdot$yr. No statistically significant evidence for $0\nu\beta\beta$ is observed, leading to a lower limit on the $0\nu\beta\beta$ half-life of $3.5\cdot10^{25}$ yr at the 90% confidence level., Comment: v1, 7 pages, 5 figures; v2, fix references; v3, update to accepted version
Published: 2019
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34. Evaluation of phytase dose effect on performance, bone mineralization, and prececal phosphorus digestibility in broilers fed diets with varying metabolizable energy, digestible amino acids, and available phosphorus concentration

Author: Cozannet, P., Jlali, M., Moore, D., Archibeque, M., and Preynat, A.
Published: 2023
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35. Characterization of the Hamamatsu VUV4 MPPCs for nEXO

Author: Gallina, G., Giampa, P., Retiere, F., Kroeger, J., Zhang, G., Ward, M., Margetak, P., Lic, G., Tsang, T., Doria, L., Kharusi, S. Al, Alfaris, M., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Blatchford, J., Brodsky, J. P., Brown, E., Brunner, T., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Croix, A. De St., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Elbeltagi, M., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Feyzbakhsh, S., Fontaine, R., Gautam, P., Giacomini, G., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hoßl, J., House, A., Hughes, M., Ito, Y., Iverson, A., Jamil, A., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Krucken, R., Kuchenkov, A., Kumar, K. S., Lana, Y., Larson, A., Lenardo, B. G., Leonarda, D. S., Lik, S., Li, Z., Licciardi, C., Linw, Y. H., Lv, P., MacLellan, R., McElroy, T., Medina-Peregrina, M., Michel, T., Mong, B., Moore, D. C., Murray, K., Nakarmi, P., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepkez, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rescia, S., Richman, M., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Vachon, F., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wagenpfeil, M., Walent, M., Wang, Q., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wu, S. X., Wu, W. H., Wu, X., Xia, Q., Yang, H., Yang, L., Yen, Y. -R., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: In this paper we report on the characterization of the Hamamatsu VUV4 (S/N: S13370-6152) Vacuum Ultra-Violet (VUV) sensitive Silicon Photo-Multipliers (SiPMs) as part of the development of a solution for the detection of liquid xenon scintillation light for the nEXO experiment. Various SiPM features, such as: dark noise, gain, correlated avalanches, direct crosstalk and Photon Detection Efficiency (PDE) were measured in a dedicated setup at TRIUMF. SiPMs were characterized in the range $163 \text{ } \text{K} \leq \text{T}\leq 233 \text{ } \text{K}$. At an over voltage of $3.1\pm0.2$ V and at $\text{T}=163 \text{ }\text{K}$ we report a number of Correlated Avalanches (CAs) per pulse in the $1 \upmu\text{s}$ interval following the trigger pulse of $0.161\pm0.005$. At the same settings the Dark-Noise (DN) rate is $0.137\pm0.002 \text{ Hz/mm}^{2}$. Both the number of CAs and the DN rate are within nEXO specifications. The PDE of the Hamamatsu VUV4 was measured for two different devices at $\text{T}=233 \text{ }\text{K}$ for a mean wavelength of $189\pm7\text{ nm}$. At $3.6\pm0.2$ V and $3.5\pm0.2$ V of over voltage we report a PDE of $13.4\pm2.6\text{ }\%$ and $11\pm2\%$, corresponding to a saturation PDE of $14.8\pm2.8\text{ }\%$ and $12.2\pm2.3\%$, respectively. Both values are well below the $24\text{ }\%$ saturation PDE advertised by Hamamatsu. More generally, the second device tested at $3.5\pm0.2$ V of over voltage is below the nEXO PDE requirement. The first one instead yields a PDE that is marginally close to meeting the nEXO specifications. This suggests that with modest improvements the Hamamatsu VUV4 MPPCs could be considered as an alternative to the FBK-LF SiPMs for the final design of the nEXO detector.
Published: 2019
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36. Synthesis of two-dimensional van der waals superlattices, heterostructures, and alloys from conversion of sequentially layered sub-nanometer metal films

Author: Motala, M.J., Zhang, X., Kumar, P., Oliveira, E.F., Benton, A., Miesle, P., Rao, R., Stevenson, P.R., Moore, D., Alfieri, A., Lynch, J., Austin, D., Post, S., Gao, G., Ma, S., Zhu, H., Wang, Z., Petrov, I., Stach, E.A., Kennedy, W.J., Vangala, S., Tour, J.M., Galvao, D.S., Jariwala, D., Muratore, C., Snure, M., Ajayan, P.M., and Glavin, N.R.
Published: 2023
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37. Equipment for thermal emittance measurements above 1,400 degrees K : annual summary report January, 1964

Author: Moore, D. G.
Subjects: Spectral reflectance -- Measurement., Spectral reflectance -- Measurement.
Published: 1964

38. Equipment for thermal emittance measurements above 1,400 degrees K : annual summary report January, 1963

Author: Moore, D. G.
Subjects: Spectral reflectance -- Measurement., Spectral reflectance -- Measurement.
Published: 1963

39. Good mid- to long-term results of the cemented oxford phase 3 unicompartmental knee arthroplasty in a non-designer centre

Author: Moore, D. M., Sheridan, G. A., Welch-Phillips, A., O’Byrne, J. M., and Kenny, P.
Published: 2022
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40. Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling

Author: Hobor, S, Al Bakir, M, Hiley, C, Skrzypski, M, Frankell, A, Bakker, B, Watkins, T, Markovets, A, Dry, J, Brown, A, van der Aart, J, van den Bos, H, Spierings, D, Oukrif, D, Novelli, M, Chakrabarti, T, Rabinowitz, A, Ait Hassou, L, Litiere, S, Kerr, D, Tan, L, Kelly, G, Moore, D, Renshaw, M, Venkatesan, S, Hill, W, Huebner, A, Martinez-Ruiz, C, Black, J, Wu, W, Angelova, M, Mcgranahan, N, Downward, J, Chmielecki, J, Barrett, C, Litchfield, K, Chew, S, Blakely, C, de Bruin, E, Foijer, F, Vousden, K, Bivona, T, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Tufail, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, French, J, Gilbert, K, Naidu, B, Patel, A, Osman, A, Enstone, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totton, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Paiva-Correia, A, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Brown, K, Carter, M, Chaturvedi, A, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Van Loo, P, Birkbak, N, Szallasi, Z, Kisistok, J, Sokac, M, Salgado, R, Diossy, M, Demeulemeester, J, Bunkum, A, Dwornik, A, Magness, A, Rowan, A, Karamani, A, Toncheva, A, Chain, B, Castignani, C, Bailey, C, Abbosh, C, Puttick, C, Weeden, C, Lee, C, Richard, C, Naceur-Lombardelli, C, Pearce, D, Karagianni, D, Biswas, D, Levi, D, Larose Cadieux, E, Lim, E, Colliver, E, Nye, E, Galvez-Cancino, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Noorani, I, Goldman, J, Reading, J, Rane, J, Nicod, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Grigoriadis, K, Thakkar, K, Ensell, L, Shah, M, Litovchenko, M, Jamal-Hanjani, M, Werner Sunderland, M, Huska, M, Hill, M, Dietzen, M, Leung, M, Escudero, M, Tanic, M, Sivakumar, M, Chervova, O, Lucas, O, Pich, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Vendramin, R, Saghafinia, S, Gamble, S, Veeriah, S, Ung, S, Quezada, S, Vanloo, S, Hessey, S, Ward, S, Harries, S, Boeing, S, Beck, S, Bola, S, Karasaki, T, Denner, T, Marafioti, T, Jones, T, Spanswick, V, Barbe, V, Lu, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Kaplar, Z, Bandula, S, Hackshaw, A, Hacker, A, Sharp, A, Smith, S, Kaur Dhanda, H, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Richards, J, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Kidd, A, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Hynds, R, Kanu, N, Zaccaria, S, Gronroos, E, Swanton, C, Hobor S., Al Bakir M., Hiley C. T., Skrzypski M., Frankell A. M., Bakker B., Watkins T. B. K., Markovets A., Dry J. R., Brown A. P., van der Aart J., van den Bos H., Spierings D., Oukrif D., Novelli M., Chakrabarti T., Rabinowitz A. H., Ait Hassou L., Litiere S., Kerr D. L., Tan L., Kelly G., Moore D. A., Renshaw M. J., Venkatesan S., Hill W., Huebner A., Martinez-Ruiz C., Black J. R. M., Wu W., Angelova M., McGranahan N., Downward J., Chmielecki J., Barrett C., Litchfield K., Chew S. K., Blakely C. M., de Bruin E. C., Foijer F., Vousden K. H., Bivona T. G., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Tufail M., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., French J., Gilbert K., Naidu B., Patel A. J., Osman A., Enstone C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totton N., Montero A., Smith E., Fontaine E., Granato F., Paiva-Correia A., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P. A. J., Brown K. D., Carter M., Chaturvedi A., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Van Loo P., Birkbak N. J., Szallasi Z., Kisistok J., Sokac M., Salgado R., Diossy M., Demeulemeester J., Bunkum A., Dwornik A., Magness A., Rowan A. J., Karamani A., Toncheva A., Chain B., Castignani C., Bailey C., Abbosh C., Puttick C., Weeden C. E., Lee C., Richard C., Naceur-Lombardelli C., Pearce D. R., Karagianni D., Biswas D., Levi D., Larose Cadieux E., Lim E. L., Colliver E., Nye E., Galvez-Cancino F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G. -T., Lowe H. L., Matos I. G., Noorani I., Goldman J., Reading J. L., Rane J. K., Nicod J., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Grigoriadis K., Thakkar K., Ensell L., Shah M., Litovchenko M., Jamal-Hanjani M., Werner Sunderland M., Huska M. R., Hill M. S., Dietzen M., Leung M. M., Escudero M., Tanic M., Sivakumar M., Chervova O., Lucas O., Pich O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Vendramin R., Saghafinia S., Gamble S., Veeriah S., Ung S. K. A., Quezada S. A., Vanloo S., Hessey S., Ward S., Harries S., Boeing S., Beck S., Bola S. K., Karasaki T., Denner T., Marafioti T., Jones T. P., Spanswick V., Barbe V., Lu W. -T., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Gorman P., Khiroya R., Stephens R. C. M., Wong Y. N. S., Kaplar Z., Bandula S., Hackshaw A., Hacker A. -M., Sharp A., Smith S., Kaur Dhanda H., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Richards J., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Kidd A., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Hynds R. E., Kanu N., Zaccaria S., Gronroos E., Swanton C., Hobor, S, Al Bakir, M, Hiley, C, Skrzypski, M, Frankell, A, Bakker, B, Watkins, T, Markovets, A, Dry, J, Brown, A, van der Aart, J, van den Bos, H, Spierings, D, Oukrif, D, Novelli, M, Chakrabarti, T, Rabinowitz, A, Ait Hassou, L, Litiere, S, Kerr, D, Tan, L, Kelly, G, Moore, D, Renshaw, M, Venkatesan, S, Hill, W, Huebner, A, Martinez-Ruiz, C, Black, J, Wu, W, Angelova, M, Mcgranahan, N, Downward, J, Chmielecki, J, Barrett, C, Litchfield, K, Chew, S, Blakely, C, de Bruin, E, Foijer, F, Vousden, K, Bivona, T, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Tufail, M, Scotland, M, Boyles, R, Rathinam, S, Wilson, C, Marrone, D, Dulloo, S, Fennell, D, Matharu, G, Shaw, J, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, French, J, Gilbert, K, Naidu, B, Patel, A, Osman, A, Enstone, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totton, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Paiva-Correia, A, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Brown, K, Carter, M, Chaturvedi, A, Oliveira, P, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Wilson, G, Rosenthal, R, Van Loo, P, Birkbak, N, Szallasi, Z, Kisistok, J, Sokac, M, Salgado, R, Diossy, M, Demeulemeester, J, Bunkum, A, Dwornik, A, Magness, A, Rowan, A, Karamani, A, Toncheva, A, Chain, B, Castignani, C, Bailey, C, Abbosh, C, Puttick, C, Weeden, C, Lee, C, Richard, C, Naceur-Lombardelli, C, Pearce, D, Karagianni, D, Biswas, D, Levi, D, Larose Cadieux, E, Lim, E, Colliver, E, Nye, E, Galvez-Cancino, F, Gimeno-Valiente, F, Kassiotis, G, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Noorani, I, Goldman, J, Reading, J, Rane, J, Nicod, J, Hartley, J, Peggs, K, Enfield, K, Selvaraju, K, Thol, K, Ng, K, Chen, K, Dijkstra, K, Grigoriadis, K, Thakkar, K, Ensell, L, Shah, M, Litovchenko, M, Jamal-Hanjani, M, Werner Sunderland, M, Huska, M, Hill, M, Dietzen, M, Leung, M, Escudero, M, Tanic, M, Sivakumar, M, Chervova, O, Lucas, O, Pich, O, Al-Sawaf, O, Prymas, P, Hobson, P, Pawlik, P, Stone, R, Bentham, R, Vendramin, R, Saghafinia, S, Gamble, S, Veeriah, S, Ung, S, Quezada, S, Vanloo, S, Hessey, S, Ward, S, Harries, S, Boeing, S, Beck, S, Bola, S, Karasaki, T, Denner, T, Marafioti, T, Jones, T, Spanswick, V, Barbe, V, Lu, W, Liu, W, Wu, Y, Naito, Y, Ramsden, Z, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Forster, M, Lee, S, Borg, E, Falzon, M, Papadatos-Pastos, D, Wilson, J, Ahmad, T, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Janes, S, Martinoni Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Gorman, P, Khiroya, R, Stephens, R, Wong, Y, Kaplar, Z, Bandula, S, Hackshaw, A, Hacker, A, Sharp, A, Smith, S, Kaur Dhanda, H, Pilotti, C, Leslie, R, Grapa, A, Zhang, H, Abduljabbar, K, Pan, X, Yuan, Y, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Cave, J, Richards, J, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Nicholson, A, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Kidd, A, Dick, C, Le Quesne, J, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Hynds, R, Kanu, N, Zaccaria, S, Gronroos, E, Swanton, C, Hobor S., Al Bakir M., Hiley C. T., Skrzypski M., Frankell A. M., Bakker B., Watkins T. B. K., Markovets A., Dry J. R., Brown A. P., van der Aart J., van den Bos H., Spierings D., Oukrif D., Novelli M., Chakrabarti T., Rabinowitz A. H., Ait Hassou L., Litiere S., Kerr D. L., Tan L., Kelly G., Moore D. A., Renshaw M. J., Venkatesan S., Hill W., Huebner A., Martinez-Ruiz C., Black J. R. M., Wu W., Angelova M., McGranahan N., Downward J., Chmielecki J., Barrett C., Litchfield K., Chew S. K., Blakely C. M., de Bruin E. C., Foijer F., Vousden K. H., Bivona T. G., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Tufail M., Scotland M., Boyles R., Rathinam S., Wilson C., Marrone D., Dulloo S., Fennell D. A., Matharu G., Shaw J. A., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., French J., Gilbert K., Naidu B., Patel A. J., Osman A., Enstone C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totton N., Montero A., Smith E., Fontaine E., Granato F., Paiva-Correia A., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P. A. J., Brown K. D., Carter M., Chaturvedi A., Oliveira P., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Wilson G. A., Rosenthal R., Van Loo P., Birkbak N. J., Szallasi Z., Kisistok J., Sokac M., Salgado R., Diossy M., Demeulemeester J., Bunkum A., Dwornik A., Magness A., Rowan A. J., Karamani A., Toncheva A., Chain B., Castignani C., Bailey C., Abbosh C., Puttick C., Weeden C. E., Lee C., Richard C., Naceur-Lombardelli C., Pearce D. R., Karagianni D., Biswas D., Levi D., Larose Cadieux E., Lim E. L., Colliver E., Nye E., Galvez-Cancino F., Gimeno-Valiente F., Kassiotis G., Stavrou G., Mastrokalos G. -T., Lowe H. L., Matos I. G., Noorani I., Goldman J., Reading J. L., Rane J. K., Nicod J., Hartley J. A., Peggs K. S., Enfield K. S. S., Selvaraju K., Thol K., Ng K. W., Chen K., Dijkstra K., Grigoriadis K., Thakkar K., Ensell L., Shah M., Litovchenko M., Jamal-Hanjani M., Werner Sunderland M., Huska M. R., Hill M. S., Dietzen M., Leung M. M., Escudero M., Tanic M., Sivakumar M., Chervova O., Lucas O., Pich O., Al-Sawaf O., Prymas P., Hobson P., Pawlik P., Stone R. K., Bentham R., Vendramin R., Saghafinia S., Gamble S., Veeriah S., Ung S. K. A., Quezada S. A., Vanloo S., Hessey S., Ward S., Harries S., Boeing S., Beck S., Bola S. K., Karasaki T., Denner T., Marafioti T., Jones T. P., Spanswick V., Barbe V., Lu W. -T., Liu W. K., Wu Y., Naito Y., Ramsden Z., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Forster M. D., Lee S. M., Borg E., Falzon M., Papadatos-Pastos D., Wilson J., Ahmad T., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Janes S. M., Martinoni Hoogenboom E., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Gorman P., Khiroya R., Stephens R. C. M., Wong Y. N. S., Kaplar Z., Bandula S., Hackshaw A., Hacker A. -M., Sharp A., Smith S., Kaur Dhanda H., Pilotti C., Leslie R., Grapa A., Zhang H., AbdulJabbar K., Pan X., Yuan Y., Chuter D., MacKenzie M., Chee S., Alzetani A., Cave J., Richards J., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Nicholson A. G., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Kidd A., Dick C., Le Quesne J., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Hynds R. E., Kanu N., Zaccaria S., Gronroos E., and Swanton C.
Abstract: The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here, we show that patients with metastatic lung adenocarcinoma harbouring co-mutations of EGFR and TP53, are more likely to have mixed intra-patient tumor responses to EGFR tyrosine kinase inhibition (TKI), compared to those with an EGFR mutation alone. The combined presence of whole genome doubling (WGD) and TP53 co-mutations leads to increased genome instability and genomic copy number aberrations in genes implicated in EGFR TKI resistance. Using mouse models and an in vitro isogenic p53-mutant model system, we provide evidence that WGD provides diverse routes to drug resistance by increasing the probability of acquiring copy-number gains or losses relative to non-WGD cells. These data provide a molecular basis for mixed tumor responses to targeted therapy, within an individual patient, with implications for therapeutic strategies.
Published: 2024

41. The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma

Author: Pan, X, Abduljabbar, K, Coelho-Lima, J, Grapa, A, Zhang, H, Cheung, A, Baena, J, Karasaki, T, Wilson, C, Sereno, M, Veeriah, S, Aitken, S, Hackshaw, A, Nicholson, A, Jamal-Hanjani, M, Le Quesne, J, Janes, S, Hacker, A, Sharp, A, Smith, S, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Lim, E, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Kidd, A, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Dick, C, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Tufail, M, Scotland, M, Boyles, R, Rathinam, S, Fennell, D, Marrone, D, Dulloo, S, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Papadatos-Pastos, D, Wilson, J, Ahmad, T, French, J, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Paiva-Correia, A, Chaturvedi, A, Priest, L, Oliveira, P, Gomes, F, Brown, K, Carter, M, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Van Loo, P, Wilson, G, Rosenthal, R, Rowan, A, Bailey, C, Lee, C, Colliver, E, Enfield, K, Hill, M, Angelova, M, Pich, O, Leung, M, Frankell, A, Hiley, C, Zhai, H, Bakir, M, Birkbak, N, Lucas, O, Huebner, A, Puttick, C, Grigoriadis, K, Dietzen, M, Biswas, D, Athanasopoulou, F, Ward, S, Demeulemeester, J, Castignani, C, Cadieux, E, Kisistok, J, Sokac, M, Szallasi, Z, Diossy, M, Salgado, R, Stewart, A, Magness, A, Weeden, C, Levi, D, Gronroos, E, Noorani, I, Goldman, J, Escudero, M, Hobson, P, Vendramin, R, Boeing, S, Denner, T, Barbe, V, Lu, W, Hill, W, Naito, Y, Ramsden, Z, Kassiotis, G, Dwornik, A, Karamani, A, Chain, B, Pearce, D, Karagianni, D, Galvez-Cancino, F, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Reading, J, Hartley, J, Selvaraju, K, Chen, K, Ensell, L, Shah, M, Litovchenko, M, Chervova, O, Pawlik, P, Hynds, R, Gamble, S, Ung, S, Bola, S, Spanswick, V, Wu, Y, Al-Sawaf, O, Jones, T, Beck, S, Tanic, M, Marafioti, T, Borg, E, Falzon, M, Khiroya, R, Toncheva, A, Abbosh, C, Richard, C, Naceur-Lombardelli, C, Gimeno-Valiente, F, Thakkar, K, Sunderland, M, Sivakumar, M, Kanu, N, Prymas, P, Saghafinia, S, Vanloo, S, Lam, J, Liu, W, Bunkum, A, Hessey, S, Zaccaria, S, Martinez-Ruiz, C, Black, J, Thol, K, Bentham, R, Litchfield, K, Mcgranahan, N, Quezada, S, Forster, M, Lee, S, Herrero, J, Nye, E, Stone, R, Nicod, J, Rane, J, Peggs, K, Ng, K, Dijkstra, K, Huska, M, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Gorman, P, Stephens, R, Wong, Y, Kaplar, Z, Bandula, S, Watkins, T, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Swanton, C, Yuan, Y, Moore, D, Pan X., AbdulJabbar K., Coelho-Lima J., Grapa A. -I., Zhang H., Cheung A. H. K., Baena J., Karasaki T., Wilson C. R., Sereno M., Veeriah S., Aitken S. J., Hackshaw A., Nicholson A. G., Jamal-Hanjani M., Le Quesne J., Janes S. M., Hacker A. -M., Sharp A., Smith S., Dhanda H. K., Chan K., Pilotti C., Leslie R., Chuter D., MacKenzie M., Chee S., Alzetani A., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Kidd A., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Dick C., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Tufail M., Scotland M., Boyles R., Rathinam S., Fennell D. A., Wilson C., Marrone D., Dulloo S., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Papadatos-Pastos D., Wilson J., Ahmad T., French J., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Paiva-Correia A., Chaturvedi A., Priest L., Oliveira P., Gomes F., Brown K., Carter M., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Van Loo P., Wilson G. A., Rosenthal R., Rowan A., Bailey C., Lee C., Colliver E., Enfield K. S. S., Hill M. S., Angelova M., Pich O., Leung M., Frankell A. M., Hiley C. T., Lim E. L., Zhai H., Bakir M. A., Birkbak N. J., Lucas O., Huebner A., Puttick C., Grigoriadis K., Dietzen M., Biswas D., Athanasopoulou F., Ward S., Demeulemeester J., Castignani C., Cadieux E. L., Kisistok J., Sokac M., Szallasi Z., Diossy M., Salgado R., Stewart A., Magness A., Weeden C. E., Levi D., Gronroos E., Noorani I., Goldman J., Escudero M., Hobson P., Vendramin R., Boeing S., Denner T., Barbe V., Lu W. -T., Hill W., Naito Y., Ramsden Z., Kassiotis G., Dwornik A., Karamani A., Chain B., Pearce D. R., Karagianni D., Galvez-Cancino F., Stavrou G., Mastrokalos G., Lowe H. L., Matos I. G., Reading J. L., Hartley J. A., Selvaraju K., Chen K., Ensell L., Shah M., Litovchenko M., Chervova O., Pawlik P., Hynds R. E., Gamble S., Ung S. K. A., Bola S. K., Spanswick V., Wu Y., Al-Sawaf O., Jones T. P., Beck S., Tanic M., Marafioti T., Borg E., Falzon M., Khiroya R., Toncheva A., Abbosh C., Richard C., Naceur-Lombardelli C., Gimeno-Valiente F., Thakkar K., Sunderland M. W., Sivakumar M., Kanu N., Prymas P., Saghafinia S., Vanloo S., Lam J. M., Liu W. K., Bunkum A., Hessey S., Zaccaria S., Martinez-Ruiz C., Black J. R. M., Thol K., Bentham R., Litchfield K., McGranahan N., Quezada S. A., Forster M. D., Lee S. M., Herrero J., Nye E., Stone R. K., Nicod J., Rane J. K., Peggs K. S., Ng K. W., Dijkstra K., Huska M. R., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Gorman P., Stephens R. C. M., Wong Y. N. S., Kaplar Z., Bandula S., Watkins T. B. K., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Swanton C., Yuan Y., Moore D. A., Pan, X, Abduljabbar, K, Coelho-Lima, J, Grapa, A, Zhang, H, Cheung, A, Baena, J, Karasaki, T, Wilson, C, Sereno, M, Veeriah, S, Aitken, S, Hackshaw, A, Nicholson, A, Jamal-Hanjani, M, Le Quesne, J, Janes, S, Hacker, A, Sharp, A, Smith, S, Dhanda, H, Chan, K, Pilotti, C, Leslie, R, Chuter, D, Mackenzie, M, Chee, S, Alzetani, A, Lim, E, De Sousa, P, Jordan, S, Rice, A, Raubenheimer, H, Bhayani, H, Ambrose, L, Devaraj, A, Chavan, H, Begum, S, Buderi, S, Kaniu, D, Malima, M, Booth, S, Fernandes, N, Shah, P, Proli, C, Hewish, M, Danson, S, Shackcloth, M, Robinson, L, Russell, P, Blyth, K, Kidd, A, Kirk, A, Asif, M, Bilancia, R, Kostoulas, N, Thomas, M, Dick, C, Lester, J, Bajaj, A, Nakas, A, Sodha-Ramdeen, A, Tufail, M, Scotland, M, Boyles, R, Rathinam, S, Fennell, D, Marrone, D, Dulloo, S, Matharu, G, Shaw, J, Riley, J, Primrose, L, Boleti, E, Cheyne, H, Khalil, M, Richardson, S, Cruickshank, T, Price, G, Kerr, K, Benafif, S, Papadatos-Pastos, D, Wilson, J, Ahmad, T, French, J, Gilbert, K, Naidu, B, Patel, A, Osman, A, Lacson, C, Langman, G, Shackleford, H, Djearaman, M, Kadiri, S, Middleton, G, Leek, A, Hodgkinson, J, Totten, N, Montero, A, Smith, E, Fontaine, E, Granato, F, Novasio, J, Rammohan, K, Joseph, L, Bishop, P, Shah, R, Moss, S, Joshi, V, Crosbie, P, Paiva-Correia, A, Chaturvedi, A, Priest, L, Oliveira, P, Gomes, F, Brown, K, Carter, M, Lindsay, C, Blackhall, F, Krebs, M, Summers, Y, Clipson, A, Tugwood, J, Kerr, A, Rothwell, D, Dive, C, Aerts, H, Schwarz, R, Kaufmann, T, Van Loo, P, Wilson, G, Rosenthal, R, Rowan, A, Bailey, C, Lee, C, Colliver, E, Enfield, K, Hill, M, Angelova, M, Pich, O, Leung, M, Frankell, A, Hiley, C, Zhai, H, Bakir, M, Birkbak, N, Lucas, O, Huebner, A, Puttick, C, Grigoriadis, K, Dietzen, M, Biswas, D, Athanasopoulou, F, Ward, S, Demeulemeester, J, Castignani, C, Cadieux, E, Kisistok, J, Sokac, M, Szallasi, Z, Diossy, M, Salgado, R, Stewart, A, Magness, A, Weeden, C, Levi, D, Gronroos, E, Noorani, I, Goldman, J, Escudero, M, Hobson, P, Vendramin, R, Boeing, S, Denner, T, Barbe, V, Lu, W, Hill, W, Naito, Y, Ramsden, Z, Kassiotis, G, Dwornik, A, Karamani, A, Chain, B, Pearce, D, Karagianni, D, Galvez-Cancino, F, Stavrou, G, Mastrokalos, G, Lowe, H, Matos, I, Reading, J, Hartley, J, Selvaraju, K, Chen, K, Ensell, L, Shah, M, Litovchenko, M, Chervova, O, Pawlik, P, Hynds, R, Gamble, S, Ung, S, Bola, S, Spanswick, V, Wu, Y, Al-Sawaf, O, Jones, T, Beck, S, Tanic, M, Marafioti, T, Borg, E, Falzon, M, Khiroya, R, Toncheva, A, Abbosh, C, Richard, C, Naceur-Lombardelli, C, Gimeno-Valiente, F, Thakkar, K, Sunderland, M, Sivakumar, M, Kanu, N, Prymas, P, Saghafinia, S, Vanloo, S, Lam, J, Liu, W, Bunkum, A, Hessey, S, Zaccaria, S, Martinez-Ruiz, C, Black, J, Thol, K, Bentham, R, Litchfield, K, Mcgranahan, N, Quezada, S, Forster, M, Lee, S, Herrero, J, Nye, E, Stone, R, Nicod, J, Rane, J, Peggs, K, Ng, K, Dijkstra, K, Huska, M, Hoogenboom, E, Monk, F, Holding, J, Choudhary, J, Bhakhri, K, Scarci, M, Gorman, P, Stephens, R, Wong, Y, Kaplar, Z, Bandula, S, Watkins, T, Veiga, C, Royle, G, Collins-Fekete, C, Fraioli, F, Ashford, P, Procter, A, Ahmed, A, Taylor, M, Nair, A, Lawrence, D, Patrini, D, Navani, N, Thakrar, R, Swanton, C, Yuan, Y, Moore, D, Pan X., AbdulJabbar K., Coelho-Lima J., Grapa A. -I., Zhang H., Cheung A. H. K., Baena J., Karasaki T., Wilson C. R., Sereno M., Veeriah S., Aitken S. J., Hackshaw A., Nicholson A. G., Jamal-Hanjani M., Le Quesne J., Janes S. M., Hacker A. -M., Sharp A., Smith S., Dhanda H. K., Chan K., Pilotti C., Leslie R., Chuter D., MacKenzie M., Chee S., Alzetani A., Lim E., De Sousa P., Jordan S., Rice A., Raubenheimer H., Bhayani H., Ambrose L., Devaraj A., Chavan H., Begum S., Buderi S. I., Kaniu D., Malima M., Booth S., Fernandes N., Shah P., Proli C., Hewish M., Danson S., Shackcloth M. J., Robinson L., Russell P., Blyth K. G., Kidd A., Kirk A., Asif M., Bilancia R., Kostoulas N., Thomas M., Dick C., Lester J. F., Bajaj A., Nakas A., Sodha-Ramdeen A., Tufail M., Scotland M., Boyles R., Rathinam S., Fennell D. A., Wilson C., Marrone D., Dulloo S., Matharu G., Shaw J. A., Riley J., Primrose L., Boleti E., Cheyne H., Khalil M., Richardson S., Cruickshank T., Price G., Kerr K. M., Benafif S., Papadatos-Pastos D., Wilson J., Ahmad T., French J., Gilbert K., Naidu B., Patel A. J., Osman A., Lacson C., Langman G., Shackleford H., Djearaman M., Kadiri S., Middleton G., Leek A., Hodgkinson J. D., Totten N., Montero A., Smith E., Fontaine E., Granato F., Novasio J., Rammohan K., Joseph L., Bishop P., Shah R., Moss S., Joshi V., Crosbie P., Paiva-Correia A., Chaturvedi A., Priest L., Oliveira P., Gomes F., Brown K., Carter M., Lindsay C. R., Blackhall F. H., Krebs M. G., Summers Y., Clipson A., Tugwood J., Kerr A., Rothwell D. G., Dive C., Aerts H. J. W. L., Schwarz R. F., Kaufmann T. L., Van Loo P., Wilson G. A., Rosenthal R., Rowan A., Bailey C., Lee C., Colliver E., Enfield K. S. S., Hill M. S., Angelova M., Pich O., Leung M., Frankell A. M., Hiley C. T., Lim E. L., Zhai H., Bakir M. A., Birkbak N. J., Lucas O., Huebner A., Puttick C., Grigoriadis K., Dietzen M., Biswas D., Athanasopoulou F., Ward S., Demeulemeester J., Castignani C., Cadieux E. L., Kisistok J., Sokac M., Szallasi Z., Diossy M., Salgado R., Stewart A., Magness A., Weeden C. E., Levi D., Gronroos E., Noorani I., Goldman J., Escudero M., Hobson P., Vendramin R., Boeing S., Denner T., Barbe V., Lu W. -T., Hill W., Naito Y., Ramsden Z., Kassiotis G., Dwornik A., Karamani A., Chain B., Pearce D. R., Karagianni D., Galvez-Cancino F., Stavrou G., Mastrokalos G., Lowe H. L., Matos I. G., Reading J. L., Hartley J. A., Selvaraju K., Chen K., Ensell L., Shah M., Litovchenko M., Chervova O., Pawlik P., Hynds R. E., Gamble S., Ung S. K. A., Bola S. K., Spanswick V., Wu Y., Al-Sawaf O., Jones T. P., Beck S., Tanic M., Marafioti T., Borg E., Falzon M., Khiroya R., Toncheva A., Abbosh C., Richard C., Naceur-Lombardelli C., Gimeno-Valiente F., Thakkar K., Sunderland M. W., Sivakumar M., Kanu N., Prymas P., Saghafinia S., Vanloo S., Lam J. M., Liu W. K., Bunkum A., Hessey S., Zaccaria S., Martinez-Ruiz C., Black J. R. M., Thol K., Bentham R., Litchfield K., McGranahan N., Quezada S. A., Forster M. D., Lee S. M., Herrero J., Nye E., Stone R. K., Nicod J., Rane J. K., Peggs K. S., Ng K. W., Dijkstra K., Huska M. R., Hoogenboom E. M., Monk F., Holding J. W., Choudhary J., Bhakhri K., Scarci M., Gorman P., Stephens R. C. M., Wong Y. N. S., Kaplar Z., Bandula S., Watkins T. B. K., Veiga C., Royle G., Collins-Fekete C. -A., Fraioli F., Ashford P., Procter A. J., Ahmed A., Taylor M. N., Nair A., Lawrence D., Patrini D., Navani N., Thakrar R. M., Swanton C., Yuan Y., and Moore D. A.
Abstract: The introduction of the International Association for the Study of Lung Cancer grading system has furthered interest in histopathological grading for risk stratification in lung adenocarcinoma. Complex morphology and high intratumoral heterogeneity present challenges to pathologists, prompting the development of artificial intelligence (AI) methods. Here we developed ANORAK (pyrAmid pooliNg crOss stReam Attention networK), encoding multiresolution inputs with an attention mechanism, to delineate growth patterns from hematoxylin and eosin-stained slides. In 1,372 lung adenocarcinomas across four independent cohorts, AI-based grading was prognostic of disease-free survival, and further assisted pathologists by consistently improving prognostication in stage I tumors. Tumors with discrepant patterns between AI and pathologists had notably higher intratumoral heterogeneity. Furthermore, ANORAK facilitates the morphological and spatial assessment of the acinar pattern, capturing acinus variations with pattern transition. Collectively, our AI method enabled the precision quantification and morphology investigation of growth patterns, reflecting intratumoral histological transitions in lung adenocarcinoma.
Published: 2024

42. AB1173 CLINICAL CORRELATES OF PHYSICAL AND MENTAL HEALTH IN EARLY SYSTEMIC SCLEROSIS: BASELINE RESULTS FROM THE COLLABORATIVE NATIONAL QUALITY AND EFFICACY (CONQUER) REGISTRY USING THE PATIENT-REPORTED OUTCOMES MEASUREMENT INFORMATION SYSTEM (PROMIS)-V29

Author: Makol, A., primary, Lamba, I., additional, Khanna, D., additional, Vanburen, J., additional, Child, A., additional, Alvey, J., additional, Assassi, S., additional, Bernstein, E., additional, Castelino, F., additional, Chung, L., additional, Evnin, L., additional, Frech, T., additional, Hant, F., additional, Hummers, L., additional, Lakin, K., additional, Lebiedz-Odrobina, D., additional, Luo, Y., additional, Molitor, J., additional, Moore, D., additional, Richardson, C., additional, Sandorfi, N., additional, Shah, A. A., additional, Shah, A., additional, Skaug, B., additional, Steen, V., additional, Volkmann, E., additional, and Gordon, J., additional
Published: 2024
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43. Defect Evolution in Tensile Loading of 316L Processed by Laser Powder Bed Fusion

Author: Miers, J. C., Moore, D. G., and Saldana, C.
Published: 2022
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44. Study of Silicon Photomultiplier Performance in External Electric Fields

Author: Sun, X. L., Tolba, T., Cao, G. F., Lv, P., Wen, L. J., Odian, A., Vachon, F., Alamre, A., Albert, J. B., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Bourque, F., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Côté, M., Craycraft, A., Cree, W., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Daughhetee, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fontaine, R., Fudenberg, D., Gallina, G., Giacomini, G., Gornea, R., Gratta, G., Hansen, E. V., Harris, D., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hufschmidt, P., Hughes, M., Ito, Y., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., Michel, T., Moe, M., Mong, B., Moore, D. C., Murray, K., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Retière, F., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Schmidt, S., Schneider, J., Sinclair, D., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Tarka, M., Todd, J., Totev, T. I., Tsang, R., Tsang, T., Veenstra, B., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wagenpfeil, M., Wang, Q., Watkins, J., Weber, M., Wei, W., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors
Abstract: We report on the performance of silicon photomultiplier (SiPM) light sensors operating in electric field strength up to 30 kV/cm and at a temperature of 149K, relative to their performance in the absence of an external electric field. The SiPM devices used in this study show stable gain, photon detection efficiency, and rates of correlated pulses, when exposed to external fields, within the estimated uncertainties. No observable physical damage to the bulk or surface of the devices was caused by the exposure., Comment: 16 pages, 12 figures, 2 tables and two conferences (INPC2016 and TIPP2017)
Published: 2018
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45. Imaging individual barium atoms in solid xenon for barium tagging in nEXO

Author: Chambers, C., Walton, T., Fairbank, D., Craycraft, A., Yahne, D. R., Todd, J., Iverson, A., Fairbank, W., Alamare, A., Albert, J. B., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Bourque, F., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, G. F., Cao, L., Cen, W. R., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Cree, W., Côté, M., Dalmasson, J., Daniels, T., Darroch, L., Daugherty, S. J., Daughhetee, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Fabris, L., Farine, J., Feyzbakhsh, S., Fontaine, R., Fudenberg, D., Giacomini, G., Gornea, R., Gratta, G., Hansen, E. V., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hufschmidt, P., Hughes, M., Ito, Y., Jamil, A., Jessiman, C., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kodroff, D., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Leonard, D. S., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., Lv, P., MacLellan, R., Michel, T., Mong, B., Moore, D. C., Murray, K., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Retière, F., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Schmidt, S., Schneider, J., Schubert, A., Sinclair, D., VIII, K. Skarpaas, Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Tolba, T., Tsang, T. I. Totev. R., Tsang, T., Vachon, F., Veenstra, B., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wagenpfeil, M., Wang, Q., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O., Zhang, X., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The search for neutrinoless double beta decay probes the fundamental properties of neutrinos, including whether or not the neutrino and antineutrino are distinct. Double beta detectors are large and expensive, so background reduction is essential for extracting the highest sensitivity. The identification, or 'tagging', of the $^{136}$Ba daughter atom from double beta decay of $^{136}$Xe provides a technique for eliminating backgrounds in the nEXO neutrinoless double beta decay experiment. The tagging scheme studied in this work utilizes a cryogenic probe to trap the barium atom in solid xenon, where the barium atom is tagged via fluorescence imaging in the solid xenon matrix. Here we demonstrate imaging and counting of individual atoms of barium in solid xenon by scanning a focused laser across a solid xenon matrix deposited on a sapphire window. When the laser sits on an individual atom, the fluorescence persists for $\sim$30~s before dropping abruptly to the background level, a clear confirmation of one-atom imaging. No barium fluorescence persists following evaporation of a barium deposit to a limit of $\leq$0.16\%. This is the first time that single atoms have been imaged in solid noble element. It establishes the basic principle of a barium tagging technique for nEXO.
Published: 2018

46. VUV-sensitive Silicon Photomultipliers for Xenon Scintillation Light Detection in nEXO

Author: Jamil, A., Ziegler, T., Hufschmidt, P., Li, G., Lupin-Jimenez, L., Michel, T., Ostrovskiy, I., Retière, F., Schneider, J., Wagenpfeil, M., Albert, J. B., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P., Beck, D., Belov, V., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Côté, M., Dalmasson, J., Daniels, T., Daugherty, S. J., Daughhetee, J., Delaquis, S., Der Mesrobian-Kabakian, A., DeVoe, R., Didberidze, T., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Feyzbakhsh, S., Fontaine, R., Fudenberg, D., Gallina, G., Giacomini, G., Gornea, R., Gratta, G., Hansen, E. V., Harris, D., Hasan, M., Heffner, M., Hoppe, E. W., House, A., Hughes, M., Hößl, J., Ito, Y., Iverson, A., Jewell, M., Jiang, X. S., Karelin, A., Kaufman, L. J., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, S., Li, Z., Licciardi, C., Lin, Y. H., MacLellan, R., Mong, B., Moore, D., Murray, K., Newby, R. J., Ning, Z., Njoya, O., Nolet, F., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Overman, C. T., Ortega, G. S., Parent, S., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Saldanha, R., Sangiorgio, S., Schmidt, S., Schubert, A., Sinclair, D., Skarpaas, K., Soma, A. K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Tsang, R., Tsang, T., Vachon, F., Veeraraghavan, V., Visser, G., Vuilleumier, J. -L., Wang, Q., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O., Zhang, X., Zhao, J., and Zhou, Y.
Subjects: Physics - Instrumentation and Detectors
Abstract: Future tonne-scale liquefied noble gas detectors depend on efficient light detection in the VUV range. In the past years Silicon Photomultipliers (SiPMs) have emerged as a valid alternative to standard photomultiplier tubes or large area avalanche photodiodes. The next generation double beta decay experiment, nEXO, with a 5 tonne liquid xenon time projection chamber, will use SiPMs for detecting the $178\,\text{nm}$ xenon scintillation light, in order to achieve an energy resolution of $\sigma / Q_{\beta\beta} = 1\, \%$. This paper presents recent measurements of the VUV-HD generation SiPMs from Fondazione Bruno Kessler in two complementary setups. It includes measurements of the photon detection efficiency with gaseous xenon scintillation light in a vacuum setup and dark measurements in a dry nitrogen gas setup. We report improved photon detection efficiency at $175\,\text{nm}$ compared to previous generation devices, that would meet the criteria of nEXO. Furthermore, we present the projected nEXO detector light collection and energy resolution that could be achieved by using these SiPMs., Comment: 11 pages, 13 figures, 2 tables
Published: 2018
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47. nEXO Pre-Conceptual Design Report

Author: nEXO Collaboration, Kharusi, S. Al, Alamre, A., Albert, J. B., Alfaris, M., Anton, G., Arnquist, I. J., Badhrees, I., Barbeau, P. S., Beck, D., Belov, V., Bhatta, T., Bourque, F., Brodsky, J. P., Brown, E., Brunner, T., Burenkov, A., Cao, G. F., Cao, L., Cen, W. R., Chambers, C., Charlebois, S. A., Chiu, M., Cleveland, B., Conley, R., Coon, M., Côté, M., Craycraft, A., Cree, W., Dalmasson, J., Daniels, T., Danovitch, D., Darroch, L., Daugherty, S. J., Daughhetee, J., DeVoe, R., Delaquis, S., Der Mesrobian-Kabakian, A., Di Vacri, M. L., Dilling, J., Ding, Y. Y., Dolinski, M. J., Dragone, A., Echevers, J., Fabris, L., Fairbank, D., Fairbank, W., Farine, J., Ferrara, S., Feyzbakhsh, S., Fierlinger, P., Fontaine, R., Fudenberg, D., Gallina, G., Giacomini, G., Gornea, R., Gratta, G., Haller, G., Hansen, E. V., Harris, D., Hasi, J., Heffner, M., Hoppe, E. W., Hößl, J., House, A., Hufschmidt, P., Hughes, M., Ito, Y., Iverson, A., Jamil, A., Jessiman, C., Jewell, M. J., Jiang, X. S., Karelin, A., Kaufman, L. J., Kenney, C., Killick, R., Kodroff, D., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Larson, A., Lenardo, B. G., Leonard, D. S., Lewis, C. M., Li, G., Li, S., Li, Z., Licciardi, C., Lin, Y. H., Lv, P., MacLellan, R., McFarlane, K., Michel, T., Mong, B., Moore, D. C., Murray, K., Newby, R. J., Nguyen, T., Ning, Z., Njoya, O., Nolet, F., Nusair, O., Odgers, K., Odian, A., Oriunno, M., Orrell, J. L., Ortega, G. S., Ostrovskiy, I., Overman, C. T., Parent, S., Patel, M., Peña-Perez, A., Piepke, A., Pocar, A., Pratte, J. -F., Qiu, D., Radeka, V., Raguzin, E., Rao, T., Rescia, S., Retière, F., Robinson, A., Rossignol, T., Rowson, P. C., Roy, N., Runge, J., Saldanha, R., Sangiorgio, S., Schmidt, S., Schneider, J., Schubert, A., Segal, J., Skarpaas~VIII, K., Soma, A. K., Spitaels, K., St-Hilaire, G., Stekhanov, V., Stiegler, T., Sun, X. L., Tarka, M., Todd, J., Tolba, T., Totev, T. I., Tsang, R., Tsang, T., Vachon, F., Veenstra, B., Veeraraghavan, V., Visser, G., Vogel, P., Vuilleumier, J. -L., Wagenpfeil, M., Wang, Q., Ward, M., Watkins, J., Weber, M., Wei, W., Wen, L. J., Wichoski, U., Wrede, G., Wu, S. X., Wu, W. H., Xia, Q., Yang, L., Yen, Y. -R., Zeldovich, O., Zhang, X., Zhao, J., Zhou, Y., and Ziegler, T.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The projected performance and detector configuration of nEXO are described in this pre-Conceptual Design Report (pCDR). nEXO is a tonne-scale neutrinoless double beta ($0\nu\beta\beta$) decay search in $^{136}$Xe, based on the ultra-low background liquid xenon technology validated by EXO-200. With $\simeq$ 5000 kg of xenon enriched to 90% in the isotope 136, nEXO has a projected half-life sensitivity of approximately $10^{28}$ years. This represents an improvement in sensitivity of about two orders of magnitude with respect to current results. Based on the experience gained from EXO-200 and the effectiveness of xenon purification techniques, we expect the background to be dominated by external sources of radiation. The sensitivity increase is, therefore, entirely derived from the increase of active mass in a monolithic and homogeneous detector, along with some technical advances perfected in the course of a dedicated R&D program. Hence the risk which is inherent to the construction of a large, ultra-low background detector is reduced, as the intrinsic radioactive contamination requirements are generally not beyond those demonstrated with the present generation $0\nu\beta\beta$ decay experiments. Indeed, most of the required materials have been already assayed or reasonable estimates of their properties are at hand. The details described herein represent the base design of the detector configuration as of early 2018. Where potential design improvements are possible, alternatives are discussed. This design for nEXO presents a compelling path towards a next generation search for $0\nu\beta\beta$, with a substantial possibility to discover physics beyond the Standard Model., Comment: 182 pages, minor revisions
Published: 2018

48. Deep Neural Networks for Energy and Position Reconstruction in EXO-200

Author: Delaquis, S., Jewell, M. J., Ostrovskiy, I., Weber, M., Ziegler, T., Dalmasson, J., Kaufman, L. J., Richards, T., Albert, J. B., Anton, G., Badhrees, I., Barbeau, P. S., Bayerlein, R., Beck, D., Belov, V., Breidenbach, M., Brunner, T., Cao, G. F., Cen, W. R., Chambers, C., Cleveland, B., Coon, M., Craycraft, A., Cree, W., Daniels, T., Danilov, M., Daugherty, S. J., Daughhetee, J., Davis, J., Der Mesrobian-Kabakian, A., DeVoe, R., Dilling, J., Dolgolenko, A., Dolinski, M. J., Fairbank Jr., W., Farine, J., Feyzbakhsh, S., Fierlinger, P., Fudenberg, D., Gornea, R., Gratta, G., Hall, C., Hansen, E. V., Harris, D., Hoessl, J., Hufschmidt, P., Hughes, M., Iverson, A., Jamil, A., Johnson, A., Karelin, A., Koffas, T., Kravitz, S., Krücken, R., Kuchenkov, A., Kumar, K. S., Lan, Y., Leonard, D. S., Li, G. S., Li, S., Licciardi, C., Lin, Y. H., MacLellan, R., Michel, T., Mong, B., Moore, D., Murray, K., Njoya, O., Odian, A., Piepke, A., Pocar, A., Retière, F., Robinson, A. L., Rowson, P. C., Schmidt, S., Schubert, A., Sinclair, D., Soma, A. K., Stekhanov, V., Tarka, M., Todd, J., Tolba, T., Veeraraghavan, V., Vuilleumier, J. -L., Wagenpfeil, M., Waite, A., Watkins, J., Wen, L. J., Wichoski, U., Wrede, G., Xia, Q., Yang, L., Yen, Y. -R., and Zeldovich, O. Ya.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract: We apply deep neural networks (DNN) to data from the EXO-200 experiment. In the studied cases, the DNN is able to reconstruct the relevant parameters - total energy and position - directly from raw digitized waveforms, with minimal exceptions. For the first time, the developed algorithms are evaluated on real detector calibration data. The accuracy of reconstruction either reaches or exceeds what was achieved by the conventional approaches developed by EXO-200 over the course of the experiment. Most existing DNN approaches to event reconstruction and classification in particle physics are trained on Monte Carlo simulated events. Such algorithms are inherently limited by the accuracy of the simulation. We describe a unique approach that, in an experiment such as EXO-200, allows to successfully perform certain reconstruction and analysis tasks by training the network on waveforms from experimental data, either reducing or eliminating the reliance on the Monte Carlo., Comment: Accepted version. 33 pages, 28 figures
Published: 2018
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49. Nuclear-recoil energy scale in CDMS II silicon dark-matter detectors

Author: Agnese, R., Anderson, A. J., Aramaki, T., Baker, W., Balakishiyeva, D., Banik, S., Barker, D., Thakur, R. Basu, Bauer, D. A., Binder, T., Borgland, A., Bowles, M. A., Brink, P. L., Bunker, R., Cabrera, B., Caldwell, D. O., Calkins, R., Cartaro, C., Cerdeno, D. G., Chagani, H., Chang, Y. -Y., Chen, Y., Cooley, J., Cornell, B., Cushman, P., Daal, M., Doughty, T., Dragowsky, E. M., Esteban, L., Fallows, S., Fascione, E., Figueroa-Feliciano, E., Fritts, M., Gerbier, G., Germond, R., Ghaith, M., Godfrey, G. L., Golwala, S. R., Hall, J., Harris, H. R., Holmgren, D., Hong, Z., Hsu, L., Huber, M. E., Iyer, V., Jardin, D., Jastram, A., Jena, C., Kelsey, M. H., Kennedy, A., Kubik, A., Kurinsky, N. A., Leder, A., Asamar, E. Lopez, Lukens, P., MacDonell, D., Mahapatra, R., Mandic, V., Mast, N., McCarthy, K. A., Miller, E. H., Mirabolfathi, N., Moffatt, R. A., Mohanty, B., Moore, D., Mendoza, J. D. Morales, Nelson, J., Oser, S. M., Page, K., Page, W. A., Partridge, R., Martinez, M. Penalver, Pepin, M., Phipps, A., Poudel, S., Pyle, M., Qiu, H., Rau, W., Redl, P., Reisetter, A., Roberts, A., Rogers, H. E., Robinson, A. E., Saab, T., Sadoulet, B., Sander, J., Schneck, K., Schnee, R. W., Scorza, S., Senapati, K., Serfass, B., Speller, D., Di Stefano, P. C. F., Stein, M., Street, J., Tanaka, H. A., Toback, D., Underwood, R., Villano, A. N., von Krosigk, B., Welliver, B., Wilson, J. S., Wilson, M. J., Wright, D. H., Yellin, S., Yen, J. J., Young, B. A., Zhang, X., and Zhao, X.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: The Cryogenic Dark Matter Search (CDMS II) experiment aims to detect dark matter particles that elastically scatter from nuclei in semiconductor detectors. The resulting nuclear-recoil energy depositions are detected by ionization and phonon sensors. Neutrons produce a similar spectrum of low-energy nuclear recoils in such detectors, while most other backgrounds produce electron recoils. The absolute energy scale for nuclear recoils is necessary to interpret results correctly. The energy scale can be determined in CDMS II silicon detectors using neutrons incident from a broad-spectrum $^{252}$Cf source, taking advantage of a prominent resonance in the neutron elastic scattering cross section of silicon at a recoil (neutron) energy near 20 (182) keV. Results indicate that the phonon collection efficiency for nuclear recoils is $4.8^{+0.7}_{-0.9}$% lower than for electron recoils of the same energy. Comparisons of the ionization signals for nuclear recoils to those measured previously by other groups at higher electric fields indicate that the ionization collection efficiency for CDMS II silicon detectors operated at $\sim$4 V/cm is consistent with 100% for nuclear recoils below 20 keV and gradually decreases for larger energies to $\sim$75% at 100 keV. The impact of these measurements on previously published CDMS II silicon results is small., Comment: 22 pages, 17 figures, 1 table, 1 appendix
Published: 2018
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50. Neurocognitive Correlates of Chronological and Subjective Age Differences in Persons Living with HIV compared to those without HIV

Author: Kohli, M, Kamalyan, L, Pasipanodya, E, Moore, R, Letendre, S, Jeste, D, and Moore, D
Subjects: Aging, HIV/AIDS, Clinical Research, Prevention, Behavioral and Social Science, Neurosciences, Mental Health, Psychology, Cognitive Sciences, Clinical Psychology
Abstract: Abstract: Objective: Investigate the discrepancy between subjective and chronologic age by HIV-serostatus, and the association of this discrepancy with subjective neurocognitive functioning (NCF) and objective NCF. Methods: One hundred nineteen persons living with HIV (PWLH) and 98 HIV-uninfected (HIV-) adults (Mage = 50.9; SDage = 7.9) completed a comprehensive neurobehavioral battery. Subjective age was assessed using a single-item question (i.e., “how old do you feel?”). The difference between chronologic and subjective age resulted in subjective age discrepancy scores (SADS). Subjective NCF was measured using the Patient’s Assessment of Own Functioning Inventory; objective NCF was measured using global demographically-corrected T-scores. Linear regressions examined the association between subjective and objective NCF with SADS, covarying for significant PLWH and HIV- group differences (i.e., education, sex, ethnicity, and lifetime Major Depressive Disorder). Results: PLWH reported lower SADS (indicating closer correspondence between chronologic and subjective age) than their HIV- counterparts, who reported feeling much younger (p = .05; 95% CI: -5.4, .001). Among PLWH, better subjective NCF was significantly related to greater SADS (p = .0002; 95% CI: -.48, -.16). Objective NCF was not associated with SADS among persons with and without HIV. Conclusions: Adults without HIV reported feeling younger than their chronologic age, whereas PLWH felt significantly closer to their chronologic age. SADS were negatively associated with only subjective NCF, among only PLWH. This suggests perceived cognitive functioning has a greater impact on psychological well-being among this group. Future research is warranted to delineate the relationship between HIV, subjective neurocognition, and psychosocial factors related to daily functioning to improve successful aging outcomes among this vulnerable population.
Published: 2019

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