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8. Management of penetrating intraperitoneal colon injuries: A meta-analysis and practice management guideline from the Eastern Association for the Surgery of Trauma

Author

Cullinane, Daniel C., Jawa, Randeep S., Como, John J., Moore, Ashlee E., Morris, David S., Cheriyan, Jerry, Guillamondegui, Oscar D., Goldberg, Stephanie R., Petrey, Laura, Schaefer, Gregory P., Khwaja, Kosar A., Rowell, Susan E., Barbosa, Ronald R., Bass, Gary A., Kasotakis, George, and Robinson, Bryce R.H.

Published
2019
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15. Trait Fear Scale

Author

Kramer, Mark D., primary, Patrick, Christopher J., additional, Hettema, John M., additional, Moore, Ashlee A., additional, Sawyers, Chelsea K., additional, and Yancey, James R., additional

Published
2020
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16. TraitFearScale_Supplement_Rev1_final_1 – Supplemental material for Quantifying Dispositional Fear as Threat Sensitivity: Development and Initial Validation of a Model-Based Scale Measure

Author

Kramer, Mark D., Patrick, Christopher J., Hettema, John M., Moore, Ashlee A., Sawyers, Chelsea K., and Yancey, James R.

Subjects
FOS: Psychology, 160807 Sociological Methodology and Research Methods, 170199 Psychology not elsewhere classified, FOS: Sociology
Abstract

Supplemental material, TraitFearScale_Supplement_Rev1_final_1 for Quantifying Dispositional Fear as Threat Sensitivity: Development and Initial Validation of a Model-Based Scale Measure by Mark D. Kramer, Christopher J. Patrick, John M. Hettema, Ashlee A. Moore, Chelsea K. Sawyers and James R. Yancey in Assessment

Published
2019
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21. Fear‐potentiated startle response as an endophenotype: Evaluating metrics and methods for genetic applications

Author

Savage, Jeanne E., primary, Moore, Ashlee A., additional, Sawyers, Chelsea K., additional, Bourdon, Jessica L., additional, Verhulst, Brad, additional, Carney, Dever M., additional, Moroney, Elizabeth, additional, Machlin, Laura, additional, Kaabi, Oumaima, additional, Vrana, Scott, additional, Grillon, Christian, additional, Brotman, Melissa A., additional, Leibenluft, Ellen, additional, Pine, Daniel S., additional, Roberson‐Nay, Roxann, additional, and Hettema, John M., additional

Published
2019
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22. Quantifying Dispositional Fear as Threat Sensitivity: Development and Initial Validation of a Model-Based Scale Measure.

Author

Kramer, Mark D., Patrick, Christopher J., Hettema, John M., Moore, Ashlee A., Sawyers, Chelsea K., and Yancey, James R.

Subjects
ALLERGIES, DISCRIMINANT analysis, EXPERIMENTAL design, FEAR, RESEARCH methodology, PERSONALITY, PATHOLOGICAL psychology, QUESTIONNAIRES, RESEARCH evaluation, SELF-evaluation, RESEARCH methodology evaluation
Abstract

The Research Domain Criteria initiative aims to reorient the focus of psychopathology research toward biobehavioral constructs that cut across different modalities of measurement, including self-report and neurophysiology. Constructs within the Research Domain Criteria framework are intentionally transdiagnostic, with the construct of "acute threat," for example, broadly relevant to clinical problems and associated traits involving fearfulness and stress reactivity. A potentially valuable referent for research on the construct of acute threat is a structural model of fear/fearlessness questionnaires known to predict variations in physiological threat reactivity as indexed by startle potentiation. The aim of the current work was to develop an efficient, item-based scale measure of the general factor of this structural model for use in studies of dispositional threat sensitivity and its relationship to psychopathology. A self-report scale consisting of 44 items from a conceptually relevant, nonproprietary questionnaire was first developed in a sample of 1,307 student participants, using the general factor of the fear/fearlessness model as a direct referent. This new Trait Fear scale was then evaluated for convergent and discriminant validity with measures of personality and psychopathology in a separate sample (n = 213) consisting of community adults and undergraduate students. The strong performance of the scale in this criterion-validation sample suggests that it can provide an effective means for indexing variations along a dispositional continuum of fearfulness reflecting variations in sensitivity to acute threat. [ABSTRACT FROM AUTHOR]

Published
2020
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24. Polygenic prediction of the phenome, across ancestry, in emerging adulthood

Author

Docherty, Anna R., primary, Moscati, Arden, additional, Dick, Danielle, additional, Savage, Jeanne E., additional, Salvatore, Jessica E., additional, Cooke, Megan, additional, Aliev, Fazil, additional, Moore, Ashlee A., additional, Edwards, Alexis C., additional, Riley, Brien P., additional, Adkins, Daniel E., additional, Peterson, Roseann, additional, Webb, Bradley T., additional, Bacanu, Silviu A., additional, and Kendler, Kenneth S., additional

Published
2017
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27. Genome-Wide Polygenic Atlas of the Phenome in Emerging Adulthood: Prediction of Behavioral and Health Outcomes

Author

Moscati, Arden, primary, Docherty, Anna, additional, Savage, Jeanne, additional, Salvatore, Jessica, additional, Cooke, Megan, additional, Aliev, Fazil, additional, Moore, Ashlee, additional, Peterson, Roseann, additional, Edwards, Alexis, additional, Riley, Brien, additional, Adkins, Daniel, additional, Webb, Bradley, additional, Dick, Danielle, additional, Bacanu, Silviu, additional, and Kendler, Kenneth, additional

Published
2017
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28. Genome-Wide Polygenic Atlas of The Phenome In Emerging Adulthood: Genetic Overlap of Risk Across Five Ancestries

Author

Docherty, Anna, primary, Moscati, Arden, additional, Savage, Jeanne, additional, Salvatore, Jessica, additional, Cooke, Megan, additional, Aliev, Fazil, additional, Moore, Ashlee, additional, Peterson, Roseann, additional, Edwards, Alexis, additional, Riley, Brien, additional, Adkins, Daniel, additional, Webb, Bradley, additional, Dick, Danielle, additional, Bacanu, Silviu, additional, and Kendler, Kenneth, additional

Published
2017
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30. Unpacking Genetic Risk Pathways for College Student Alcohol Consumption: The Mediating Role of Impulsivity

Author

Ksinan, Albert J., Su, Jinni, Aliev, Fazil, Dick, Danielle M., Pedersen, Kimberly, Neale, Zoe, Thomas, Nathaniel, Adkins, Amy E., Bannard, Thomas, Cho, Seung B., Barr, Peter, Berenz, Erin C., Caraway, Erin, Clifford, James S., Cooke, Megan, Do, Elizabeth, Edwards, Alexis C., Goyal, Neeru, Hack, Laura M., Halberstadt, Lisa J., Hawn, Sage, Kuo, Sally, Lasko, Emily, Lend, Jennifer, Lind, Mackenzie, Long, Elizabeth, Martelli, Alexandra, Meyers, Jacquelyn L., Mitchell, Kerry, Moore, Ashlee, Moscati, Arden, Nasim, Aashir, Opalesky, Jill, Overstreet, Cassie, Christian Pais, A., Raldiris, Tarah, Salvatore, Jessica, Savage, Jeanne, Smith, Rebecca, Sosnowski, David, Walker, Chloe, Walsh, Marcie, Willoughby, Teresa, Woodroof, Madison, Yan, Jia, Sun, Cuie, Wormley, Brandon, Riley, Brien, Peterson, Roseann, and Webb, Bradley T.

Abstract

The period of college represents a particularly risky developmental stage with regard to alcohol use, as college students engage in more risky drinking behaviors than their noncollege peers, and such problematic alcohol use is associated with far‐reaching negative consequences. Existing findings from genome‐wide association studies (GWAS) indicate that alcohol consumption has a complex polygenic etiology. Currently, there is a lack of studies examining genetic risk for alcohol consumption using polygenic risk scores (PRS) in college samples. In this study, we examined whether alcohol‐specific and risky behavior–related PRS were longitudinally associated with alcohol consumption among college students and whether this effect might be partially mediated by impulsivity domains. The sample included n =2,385 European ancestry (EA) and n =1,153 African ancestry (AA) college students assessed over the course of 4 years. To indicate genetic risk, 2 PRS were created based on recent large‐scale GWAS: alcohol consumption (Liu et al., 2019) —drinks per week (DPW)‐PRS and risky behaviors (Linnér et al., 2019) —RISK‐PRS. The main outcome was alcohol consumption, measured across 4 waves of follow‐up data. The UPPS‐P impulsivity subscales were examined as mediators of the genetic effect on alcohol consumption. The results from structural equation modeling showed that among EA students, both DPW‐PRS and RISK‐PRS had significant positive effects on alcohol consumption above and beyond UPPS dimensions and control variables. RISK‐PRS explained larger portion of variance in alcohol consumption than DPW‐PRS. RISK‐PRS showed a significant indirect effect on alcohol consumption through sensation seeking and lack of perseverance; no significant indirect effect of DPW‐PRS was found. No significant association of either PRS or alcohol consumption was found for AA participants. The current results found that PRS related to more broadly defined risky behaviors predicted alcohol consumption across college years and that this association was partially mediated via dimensions of impulsivity. This study examined the longitudinal effect of genetic risk on alcohol consumption in a college sample followed across 4 years, and tested whether dimensions of impulsivity would mediate this association. The results showed that genotypic risk score based on broader risk‐taking behaviors predicted later alcohol consumption and its effect was partially mediated by several impulsivity dimensions. This information might inform alcohol prevention efforts by identifying at‐risk individuals early on in their lifespan, preferably before the onset of alcohol use.

Published
2019
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32. Polygenic prediction of the phenome, across ancestry, in emerging adulthood.

Author

Docherty, Anna R., Moscati, Arden, Dick, Danielle, Savage, Jeanne E., Salvatore, Jessica E., Cooke, Megan, Aliev, Fazil, Moore, Ashlee A., Edwards, Alexis C., Riley, Brien P., Adkins, Daniel E., Peterson, Roseann, Webb, Bradley T., Bacanu, Silviu A., and Kendler, Kenneth S.

Subjects
MENTAL depression risk factors, PSYCHOSES, GENETICS of schizophrenia, SCHIZOPHRENIA risk factors, COGNITION disorders, PERSONALITY disorders, ANXIETY, CARDIOVASCULAR diseases risk factors, GENETIC polymorphisms, MEDICAL quality control, NEUROSES, NICOTINE, PANIC disorders, PHOBIAS, SUBSTANCE abuse, WHITE people, PHENOTYPES, FAMILY history (Medicine), ADULTS, GENETICS, MENTAL illness risk factors
Abstract

Background: Identifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology. College-age individuals are under-represented in genomic analyses thus far, and the majority of work has focused on the clinical disorder or cognitive abilities rather than normal-range behavioral outcomes. Methods: This study examined a sample of emerging adults 18–22 years of age (N = 5947) to construct an atlas of polygenic risk for 33 traits predicting relevant phenotypic outcomes. Twenty-eight hypotheses were tested based on the previous literature on samples of European ancestry, and the availability of rich assessment data allowed for polygenic predictions across 55 psychological and medical phenotypes. Results: Polygenic risk for schizophrenia (SZ) in emerging adults predicted anxiety, depression, nicotine use, trauma, and family history of psychological disorders. Polygenic risk for neuroticism predicted anxiety, depression, phobia, panic, neuroticism, and was correlated with polygenic risk for cardiovascular disease. Conclusions: These results demonstrate the extensive impact of genetic risk for SZ, neuroticism, and major depression on a range of health outcomes in early adulthood. Minimal cross-ancestry replication of these phenomic patterns of polygenic influence underscores the need for more genome-wide association studies of non-European populations. [ABSTRACT FROM AUTHOR]

Published
2018
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33. Genes, Roommates, and Residence Halls: A Multidimensional Study of the Role of Peer Drinking on College Students’ Alcohol Use

Author

Smith, Rebecca L., Salvatore, Jessica E., Aliev, Fazil, Neale, Zoe, Barr, Peter, Dick, Danielle M., Pedersen, Kimberly, Thomas, Nathaniel, Adkins, Amy E., Bannard, Thomas, Cho, Seung B., Berenz, Erin C., Caraway, Erin, Clifford, James S., Cooke, Megan, Do, Elizabeth, Edwards, Alexis C., Goyal, Neeru, Hack, Laura M., Halberstadt, Lisa J., Hawn, Sage, Kuo, Sally, Lasko, Emily, Lend, Jennifer, Lind, Mackenzie, Long, Elizabeth, Martelli, Alexandra, Meyers, Jacquelyn L., Mitchell, Kerry, Moore, Ashlee, Moscati, Arden, Nasim, Aashir, Opalesky, Jill, Overstreet, Cassie, Pais, A. Christian, Pedersen, Kimberly, Raldiris, Tarah, Salvatore, Jessica, Savage, Jeanne, Smith, Rebecca, Sosnowski, David, Su, Jinni, Walker, Chloe, Walsh, Marcie, Willoughby, Teresa, Woodroof, Madison, Yan, Jia, Sun, Cuie, Wormley, Brandon, Riley, Brien, Peterson, Roseann, and Webb, Bradley T.

Abstract

Peer drinking is one of the most robust predictors of college students’ alcohol use and can moderate students’ genetic risk for alcohol use. Peer effect research generally suffers from 2 problems: selection into peer groups and relying more on perceptions of peer alcohol use than peers’ self‐report. The goal of the present study was to overcome those limitations by capitalizing on a genetically informed sample of randomly assigned college roommates to examine multiple dimensions of peer influence and the interplay between peer effects and genetic predisposition on alcohol use, in the form of polygenic scores. We used a subsample (n =755) of participants from a university‐wide, longitudinal study at a large, diverse, urban university. Participants reported their own alcohol use during fall and spring and their perceptions of college peers’ alcohol use in spring. We matched individuals into their rooms and residence halls to create a composite score of peer‐reported alcohol use for each of those levels. We examined multiple dimensions of peer influence and whether peer influence moderated genetic predisposition to predict college students’ alcohol use using multilevel models to account for clustering at the room and residence hall level. We found that polygenic scores (β= 0.12), perceptions of peer drinking (β= 0.37), and roommates’ self‐reported drinking (β= 0.10) predicted alcohol use (all ps<0.001), while average alcohol use across residence hall did not (β= −0.01, p =0.86). We found no evidence for interactions between peer influence and genome‐wide polygenic scores for alcohol use. Our findings underscore the importance of genetic predisposition on individual alcohol use and support the potentially causal nature of the association between peer influence and alcohol use. Genetic predisposition and peer influence, including perceived and self‐reported peer behaviors, are robust predictors of college student alcohol use. Using randomly assigned roommates, we found that perceived peer drinking was the strongest predictor of alcohol use. Genetic risk (measured via polygenic scores) and roommates’ self‐reported drinking also predicted alcohol use, but average residence hall drinking did not. Our findings underscore the importance of genetic predisposition on alcohol use and support the potentially causal nature of peer influence on alcohol use.

Published
2019
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37. Potentially traumatic events, personality, and risky sexual behavior in undergraduate college students.

Author

Moore AA, Overstreet C, Kendler KS, Dick DM, Adkins A, and Amstadter AB

Subjects
Adolescent, Adult, Female, Humans, Male, Universities, Young Adult, Impulsive Behavior physiology, Interpersonal Relations, Personality physiology, Psychological Trauma psychology, Risk-Taking, Sexual Behavior psychology, Students psychology
Abstract

Objective: Impulsivity and extraversion have demonstrated associations with risky sexual behavior (RSB) and potentially traumatic events (PTEs). In addition, interpersonal trauma appears to be associated with RSB, but research on the relationship between RSB and noninterpersonal PTEs (e.g., accidental) is lacking. The current study aims to investigate the relationships between personality (i.e., impulsivity, extraversion), RSB and multiple types of PTEs (i.e., accidental, physical, or sexual)., Method: Personality and demographic characteristics were assessed during participants' (N = 970) first semester of college, past-12 month PTEs and RSB were assessed during the second semester of participants' junior year. Multiple linear regression was used to examine the relationship between PTEs, personality factors, and RSB. Analyses were also conducted to examine the potential mediating effect of interpersonal PTEs on the relationship between personality and RSB., Results: Impulsivity and extraversion were significantly positively associated with RSB. Both physical and sexual PTEs, but not accidental PTEs, were also significantly positively associated with RSB. Sexual PTEs significantly mediated the relationship between impulsivity and RSB., Conclusions: This is the first study to date to simultaneously examine the relationship between personality, RSB, and types of PTEs in a large sample of young adults. Exposure to interpersonal trauma appears to be a salient factor in the relationship between personality, specifically impulsivity, and RSB. These results indicate that college students may benefit from education regarding the potential negative outcomes of RSB, and that individuals with a history of interpersonal PTEs may be at increased risk for sexual risk taking. (PsycINFO Database Record, Competing Interests: None of the authors declare any conflict of interest., ((c) 2017 APA, all rights reserved).)

Published
2017
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