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2. Sex Differences in Outcomes of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Preadmission Use of Antiplatelets

Author

Noseda, R, Rea, F, Pagnamenta, A, Agazzi, P, Bianco, G, Sihabdeen, S, Seiffge, D, Michel, P, Nedeltchev, K, Bonati, L, Kägi, G, Niederhauser, J, Nyffeler, T, Luft, A, Wegener, S, Schelosky, L, Medlin, F, Rodic, B, Peters, N, Renaud, S, Mono, M, Carrera, E, Fischer, U, Ceschi, A, Cereda, C, Noseda, Roberta, Rea, Federico, Pagnamenta, Alberto, Agazzi, Pamela, Bianco, Giovanni, Sihabdeen, Shairin, Seiffge, David, Michel, Patrik, Nedeltchev, Krassen, Bonati, Leo, Kägi, Georg, Niederhauser, Julien, Nyffeler, Thomas, Luft, Andreas, Wegener, Susanne, Schelosky, Ludwig, Medlin, Friedrich, Rodic, Biljana, Peters, Nils, Renaud, Susanne, Mono, Marie-Luise, Carrera, Emmanuel, Fischer, Urs, Ceschi, Alessandro, Cereda, Carlo Walter, Noseda, R, Rea, F, Pagnamenta, A, Agazzi, P, Bianco, G, Sihabdeen, S, Seiffge, D, Michel, P, Nedeltchev, K, Bonati, L, Kägi, G, Niederhauser, J, Nyffeler, T, Luft, A, Wegener, S, Schelosky, L, Medlin, F, Rodic, B, Peters, N, Renaud, S, Mono, M, Carrera, E, Fischer, U, Ceschi, A, Cereda, C, Noseda, Roberta, Rea, Federico, Pagnamenta, Alberto, Agazzi, Pamela, Bianco, Giovanni, Sihabdeen, Shairin, Seiffge, David, Michel, Patrik, Nedeltchev, Krassen, Bonati, Leo, Kägi, Georg, Niederhauser, Julien, Nyffeler, Thomas, Luft, Andreas, Wegener, Susanne, Schelosky, Ludwig, Medlin, Friedrich, Rodic, Biljana, Peters, Nils, Renaud, Susanne, Mono, Marie-Luise, Carrera, Emmanuel, Fischer, Urs, Ceschi, Alessandro, and Cereda, Carlo Walter

Abstract

Aim: To compare safety and functional outcomes of intravenous thrombolysis (IVT) between females and males with acute ischaemic stroke (AIS) in relation to preadmission use of antiplatelets. Methods: Multicentre cohort study of patients admitted from 1 January 2014 to 31 January 2020 to hospitals participating in the Swiss Stroke Registry, presenting with AIS and receiving IVT. Primary safety outcome was in-hospital symptomatic intracerebral haemorrhage (sICH). Primary functional outcome was functional independence at 3 months after discharge. Multivariable logistic regression models were fitted to assess the association between sex and each outcome according to preadmission use of antiplatelets. Results: The study included 4996 patients (42.51 % females, older than males, median age 79 vs 71 years, p < 0.0001). Comparable proportions of females (39.92 %) and males (40.39 %) used antiplatelets before admission (p = 0.74). In total, 3.06 % females and 2.47 % males developed in-hospital sICH (p = 0.19), with similar odds (adjusted odds ratio, [AOR] 0.93, 95 % confidence interval, [CI] 0.63–1.39). No interaction was found between sex and preadmission use of either single or dual antiplatelets in relation to in-hospital sICH (p = 0.94 and p = 0.23). Males had higher odds of functional independence at 3 months (AOR 1.34, 95 % CI 1.09–1.65), regardless of preadmission use of antiplatelets (interaction between sex and preadmission use of either single or dual antiplatelets p = 0.41 and p = 0.58). Conclusion: No sex differences were observed in the safety of IVT regarding preadmission use of antiplatelets. Males showed more favourable 3-month functional independence than females; however, this sex difference was apparently not explained by a sex-specific mechanism related to preadmission use of antiplatelets.

Published
2023

3. Endovascular therapy outcome in isolated posterior cerebral artery occlusion strokes: A multicenter analysis of the Swiss Stroke Registry

Author

Maulucci, F, primary, Disanto, G, additional, Bianco, G, additional, Pileggi, M, additional, Fischer, U, additional, Padlina, G, additional, Strambo, D, additional, Michel, P, additional, Kahles, T, additional, Nedeltchev, K, additional, Fisch, U, additional, Bonati, L, additional, Kägi, G, additional, Escribano Paredes, JB, additional, Carrera, E, additional, Nyffeler, T, additional, Bolognese, M, additional, Wegener, S, additional, Luft, A, additional, Schelosky, L, additional, Medlin, F, additional, von Reding, A, additional, Peters, N, additional, Renaud, S, additional, Mono, M-L, additional, Remonda, L, additional, Machi, P, additional, Psychogios, M-N, additional, Kaesmacher, J, additional, Mordasini, P, additional, and Cereda, C W, additional

Published
2023
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6. Stroke severity, acute recanalization therapies and 3-month outcomes among patients with atrial fibrillation accoring to preceding anticoagulation treatment - data from the Swiss Stroke Registry

Author

Thomas Raphael Meinel, Branca, M., Nedeltchev, K., Bonati, L., Arnold, M., Carrera, E., Michel, P., Cereda, C., Bolognese, M., Kagi, G., Luft, A., Backhaus, R., Salmen, S., Sturzenegger, R., Medlin, F., Berge, C., Schelosky, L., Renaud, S., Niederhauser, J., Bonvin, C., Schaerer, M., Mono, M. -L, Rodic, B., Schwegler, G., Mordasini, P., Marchis, G. M., Kaesmacher, J., Engelter, S., Fischer, U., and Seiffge, D.

Subjects
610 Medicine & health
Published
2020
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7. Prior Stroke in PFO Patients Is Associated With Both PFO-Related and -Unrelated Factors

Author

Kahles, T, Michel, P, Hapfelmeier, A, Eberli, FR, Zedde, M, Thijs, V, Kraemer, M, Engelter, ST, Serena, J, Weimar, C, Mallmann, A, Luft, A, Hemelsoet, D, Thaler, DE, Mueller-Eichelberg, A, De Pauw, A, Sztajzel, R, Armon, C, Kent, DM, Meier, B, Mattle, HP, Fischer, U, Arnold, M, Mono, M-L, Nedeltchev, K, Kahles, T, Michel, P, Hapfelmeier, A, Eberli, FR, Zedde, M, Thijs, V, Kraemer, M, Engelter, ST, Serena, J, Weimar, C, Mallmann, A, Luft, A, Hemelsoet, D, Thaler, DE, Mueller-Eichelberg, A, De Pauw, A, Sztajzel, R, Armon, C, Kent, DM, Meier, B, Mattle, HP, Fischer, U, Arnold, M, Mono, M-L, and Nedeltchev, K

Abstract

Background and Purpose: To identify factors associated with prior stroke at presentation in patients with cryptogenic stroke (CS) and patent foramen ovale (PFO). Methods: We studied cross-sectional data from the International PFO Consortium Study (NCT00859885). Patients with first-ever stroke and those with prior stroke at baseline were analyzed for an association with PFO-related (right-to-left shunt at rest, atrial septal aneurysm, deep venous thrombosis, pulmonary embolism, and Valsalva maneuver) and PFO-unrelated factors (age, gender, BMI, hypertension, diabetes mellitus, hypercholesterolemia, smoking, migraine, coronary artery disease, aortic plaque). A multivariable analysis was used to adjust effect estimation for confounding, e.g., owing to the age-dependent definition of study groups in this cross-sectional study design. Results: We identified 635 patients with first-ever and 53 patients with prior stroke. Age, BMI, hypertension, diabetes mellitus, hypercholesterolemia, coronary artery disease, and right-to-left shunt (RLS) at rest were significantly associated with prior stroke. Using a pre-specified multivariable logistic regression model, age (Odds Ratio 1.06), BMI (OR 1.06), hypercholesterolemia (OR 1.90) and RLS at rest (OR 1.88) were strongly associated with prior stroke.Based on these factors, we developed a nomogram to illustrate the strength of the relation of individual factors to prior stroke. Conclusion: In patients with CS and PFO, the likelihood of prior stroke is associated with both, PFO-related and PFO-unrelated factors.

Published
2020

17. Microscale chemistry and green chemistry: complementary pedagogies

Author

Singh, Mono M., Szafran, Zvi, and Pike, Ronald M.

Subjects
United States. Environmental Protection Agency -- Practice, Chemistry -- Study and teaching, Environmental chemistry -- Usage, Universities and colleges -- Environmental aspects, Instructional materials industry -- Product information, Educational technology -- Environmental aspects, Chemical laboratories -- Environmental aspects, Sciences education -- Equipment and supplies, Chemistry, Education, Science and technology
Abstract

Microscale chemistry and green chemistry can be seen as complementary pedagogies. Safety can be improved when a microscale-green chemistry laboratory program is in place and money can be saved. Reaction times can be shorter. Each of the fundamental aspects of green chemistry pedagogy is discussed with examples. Topics covered include use of alternative starting materials or feedstocks in academic laboratories, nature of reagents or of transformations, nature of reaction conditions and of the target molecule or the final product, and pollution prevention.

Published
1999

20. Microscale electrolysis: synthesis of iodoform, its characterization, Faraday's Laws, and Avogadro's number

Author

Singh, Mono M., Pike, Ronald M., Szafran, Zvi, Davis, J. David, and Leone, Stephen A.

Subjects
Organic compounds -- Synthesis, Chemistry -- Study and teaching, Electrolysis -- Tests, problems and exercises, Chemistry, Education, Science and technology
Abstract

The synthesis of iodoform in the introductory chemistry laboratory can be used to illustrate the value of electrolysis in chemistry and determine Faraday's constant and Avogadro's number. Aqueous potassium iodide is electrolyzed in the presence of acetone to prepare iodoform. Experiment procedures, apparatus and reaction equations are included.

Published
1995

21. Microscale synthesis of trans-chlorocarbonylbis(triphenylphosphine)rhodium(l) and its reactions - a versatile metal carbonyl complex: an intermediate- or advanced-level inorganic chemistry experiment

Author

Singh, Mono M., Szafran, Zvi, and Pike, Ronald M.

Subjects
Chemical laboratories -- Methods, Chemistry, Inorganic -- Study and teaching, Carbon composites -- Tests, problems and exercises, Chemical reactions -- Tests, problems and exercises, Chemistry, Education, Science and technology
Published
1990

22. Impact of intravenous thrombolysis on recanalization rates in patients with stroke treated with bridging therapy

Author

Mueller, L., primary, Pult, F., additional, Meisterernst, J., additional, Heldner, M. R., additional, Mono, M.-L., additional, Kurmann, R., additional, Buehlmann, M., additional, Fischer, U., additional, Mattle, H. P., additional, Arnold, M., additional, Mordasini, P., additional, Gralla, J., additional, Schroth, G., additional, El-Koussy, M., additional, and Jung, S., additional

Published
2017
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23. Impact of Anesthesia on the Outcome of Acute Ischemic Stroke after Endovascular Treatment with the Solitaire Stent Retriever

Author

Slezak, A., primary, Kurmann, R., additional, Oppliger, L., additional, Broeg-Morvay, A., additional, Gralla, J., additional, Schroth, G., additional, Mattle, H.P., additional, Arnold, M., additional, Fischer, U., additional, Jung, S., additional, Greif, R., additional, Neff, F., additional, Mordasini, P., additional, and Mono, M.-L., additional

Published
2017
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28. Determinants of antithrombotic choice for patent foramen ovale in cryptogenic stroke

Author

Thaler, D. E., primary, Ruthazer, R., additional, Weimar, C., additional, Serena, J., additional, Mattle, H. P., additional, Nedeltchev, K., additional, Mono, M.-L., additional, Di Angelantonio, E., additional, Elkind, M. S. V., additional, Di Tullio, M. R., additional, Homma, S., additional, Michel, P., additional, Meier, B., additional, Furlan, A. J., additional, Lutz, J. S., additional, and Kent, D. M., additional

Published
2014
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29. Recurrent stroke predictors differ in medically treated patients with pathogenic vs other PFOs

Author

Thaler, D. E., primary, Ruthazer, R., additional, Weimar, C., additional, Mas, J.-L., additional, Serena, J., additional, Di Angelantonio, E., additional, Papetti, F., additional, Homma, S., additional, Mattle, H. P., additional, Nedeltchev, K., additional, Mono, M.-L., additional, Jaigobin, C., additional, Michel, P., additional, Elkind, M. S. V., additional, Di Tullio, M. R., additional, Lutz, J. S., additional, Griffith, J., additional, and Kent, D. M., additional

Published
2014
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30. A comparative study of microscale and standard burets

Author

Singh, Mono M., McGowan, Cynthia B., Szafran, Zvi, and Pike, Ronald M.

Subjects
Chemistry -- Study and teaching, Glassware -- Evaluation, Chemistry, Analytic -- Equipment and supplies, Chemistry, Education, Science and technology
Abstract

A comparative study of microscale and standard burets and their use in general and analytical chemistry has been carried out. Many titrations are performed in analytical chemistry. Use of a microburet was found to be cost effective, a timesaver and accessible for the physically challenged.

Published
2000

32. An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke

Author

Kent, D. M., primary, Ruthazer, R., additional, Weimar, C., additional, Mas, J.-L., additional, Serena, J., additional, Homma, S., additional, Di Angelantonio, E., additional, Di Tullio, M. R., additional, Lutz, J. S., additional, Elkind, M. S. V., additional, Griffith, J., additional, Jaigobin, C., additional, Mattle, H. P., additional, Michel, P., additional, Mono, M.-L., additional, Nedeltchev, K., additional, Papetti, F., additional, and Thaler, D. E., additional

Published
2013
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33. Construction of a micropycnometer for determination of density and specific gravity of liquids and solutions

Author

Singh, Mono M., Szafran, Zvi, and Pike, Ronald M.

Subjects
Specific gravity -- Measurement, Chemistry -- Equipment and supplies, Chemistry, Education, Science and technology
Abstract

Specific gravity of liquids and solutions is accurately determined using an expensive pycnometer or specific gravity bottle but a significant amount of waste material is generated. However, a micropycnometer can be constructed using an inexpensive Pasteur pipet which reduces the waste material and introduces students to capillary creation techniques using microburners, fire polishing and glass cutting. The measurements are taken by subtracting the empty weight of the micropycnometer from its weight when filled with the chosen liquid. Design directions are included.

Published
1993

36. Construction and use of an inexpensive Microburet

Author

Singh, Mono M., Szafran, Zvi, and Pike, Ronald M.

Subjects
Volumetric analysis -- Equipment and supplies, Chemical research, Chemical apparatus -- Design and construction, Chemistry, Education, Science and technology
Published
1991

37. Posterior versus anterior circulation strokes: comparison of clinical, radiological and outcome characteristics

Author

De Marchis, G. M., primary, Kohler, A., additional, Renz, N., additional, Arnold, M., additional, Mono, M.-L., additional, Jung, S., additional, Fischer, U., additional, Karameshev, A. I., additional, Brekenfeld, C., additional, Gralla, J., additional, Schroth, G., additional, Mattle, H. P., additional, and Nedeltchev, K., additional

Published
2010
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39. Low Frequency Infrared Spectra of some Carbonyl Complexes of Rhodium(I)

Author

MONO M. SINGH and DIPAK K. DUTTA

Subjects
Carbonyl Complexes, Low Frequency Infrared Spectra, Rhodium(I)
Abstract

Department of Chemistry, Merrimack College, N Andover, MA 01845, U S.A. Inorganic Chemistry Division, Regional Research Laboratory, Jorhat-785 006 Manuscript received 5 June 1992, revised 1 October 1992, accepted 5 November 1999 Low Frequency Infrared Spectra of some Carbonyl Complexes of Rhodium(I)

Published
1993
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