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1. Concepts for the Development of Person-Centered, Digitally Enabled, Artificial Intelligence–Assisted ARIA Care Pathways (ARIA 2024)

Author

Bousquet, Jean, Schünemann, Holger J., Sousa-Pinto, Bernardo, Zuberbier, Torsten, Togias, Alkis, Samolinski, Boleslaw, Bedbrook, Anna, Czarlewski, Wienczyslawa, Hofmann-Apitius, Martin, Litynska, Justyna, Vieira, Rafael José, Anto, Josep M., Fonseca, Joao A., Brozek, Jan, Bognanni, Antonio, Brussino, Luisa, Canonica, G. Walter, Cherrez-Ojeda, Ivan, Cruz, Alvaro A., Vecillas, Leticia de las, Dykewicz, Mark, Gemicioglu, Bilun, Giovannini, Mattia, Haahtela, Tari, Jacobs, Marc, Jacomelli, Cristina, Klimek, Ludger, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Louis, Gilles, Lourenço, Olga, Leemann, Lucas, Morais-Almeida, Mario, Neves, Ana Luisa, Nadeau, Kari C., Nowak, Artur, Palamarchuk, Yuliia, Palkonen, Susanna, Papadopoulos, Nikolaos G., Parmelli, Elena, Pereira, Ana Margarida, Pfaar, Oliver, Regateiro, Frederico S., Savouré, Marine, Taborda-Barata, Luis, Toppila-Salmi, Sanna K., Torres, Maria J., Valiulis, Arunas, Ventura, Maria Teresa, Williams, Sian, Yepes-Nuñez, Juan J., Yorgancioglu, Arzu, Zhang, Luo, Zuberbier, Jaron, Abdul Latiff, Amir Hamzah, Abdullah, Baharudin, Agache, Ioana, Al-Ahmad, Mona, Al-Nesf, Maryam Ali, Al Shaikh, Nada A., Amaral, Rita, Ansotegui, Ignacio J., Asllani, Julijana, Balotro-Torres, Maria Cristina, Bergmann, Karl-Christian, Bernstein, Jonathan A., Bindslev-Jensen, Carsten, Blaiss, Michael S., Bonaglia, Cristina, Bonini, Matteo, Bossé, Isabelle, Braido, Fulvio, Caballero-Fonseca, Fernan, Camargos, Paulo, Carreiro-Martins, Pedro, Casale, Thomas, Castillo-Vizuete, José-Antonio, Cecchi, Lorenzo, Teixeira, Maria do Ceu, Chang, Yoon-Seok, Loureiro, Claudia Chaves, Christoff, George, Ciprandi, Giorgio, Cirule, Ieva, Correia-de-Sousa, Jaime, Costa, Elisio M., Cvetkovski, Biljana, de Vries, Govert, Del Giacco, Stefano, Devillier, Philippe, Dokic, Dejan, Douagui, Habib, Durham, Stephen R., Enecilla, Maria Lourdes, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean-François, Gawlik, Radoslaw, Gereda, Jose E., Gil-Mata, Sara, Giuliano, Antonio F.M., Gotua, Maia, Gradauskiene, Brigita, Guzman, Maria Antonieta, Hossny, Elham, Hrubiško, Martin, Iinuma, Tomohisa, Irani, Carla, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Jartti, Tuomas, Jeseňák, Miloš, Julge, Kaja, Jutel, Marek, Kaidashev, Igor, Bennoor, Kazi S., Khaltaev, Nicolai, Kirenga, Bruce, Kraxner, Helga, Kull, Inger, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Kurchenko, Andriy, La Grutta, Stefania, Lane, Stephen, Miculinic, Neven, Lee, Sang Min, Le Thi Tuyet, Lan, Lkhagvaa, Battur, Louis, Renaud, Mahboub, Bassam, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Eric, Milenkovic, Branislava, Mohammad, Yousser, Moniuszko, Marcin, Montefort, Stephen, Moreira, Andre, Moreno, Pablo, Mullol, Joaquim, Nadif, Rachel, Nakonechna, Alla, Navarro-Locsin, Cecilia Gretchen, Neffen, Hugo E., Nekam, Kristof, Niedoszytko, Marek, Nunes, Elizabete, Nyembue, Dieudonné, O’Hehir, Robyn, Ollert, Markus, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimihiro, Olze, Heidi, Padukudru, Mahesh Anand, Palomares, Oscar, Pali-Schöll, Isabella, Panzner, Petr, Palosuo, Kati, Park, Hae S., Passalacqua, Giovanni, Patella, Vincenzo, Pawankar, Ruby, Pétré, Benoît, Pitsios, Constantinos, Plavec, Davor, Popov, Todor A., Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Ramonaité, Agné, Recto, Marysia, Repka-Ramirez, Susana, Roberts, Graham, Robles-Velasco, Karla, Roche, Nicolas, Rodriguez-Gonzalez, Monica, Romualdez, Joel A., Rottem, Menachem, Rouadi, Philip W., Salapatas, Marianella, Sastre, Joaquin, Serpa, Faradiba S., Sayah, Zineb, Scichilone, Nicola, Senna, Gianenrico, Sisul, Juan Carlos, Solé, Dirceu, Soto-Martinez, Manuel E., Sova, Milan, Sozinova, Olga, Stevanovic, Katarina, Ulrik, Charlotte Suppli, Szylling, Anna, Tan, Frances M., Tantilipikorn, Pongsakorn, Todo-Bom, Ana, Tomic-Spiric, Vesna, Tsaryk, Vladyslav, Tsiligianni, Ioanna, Urrutia-Pereira, Marilyn, Rostan, Marylin Valentin, Sofiev, Mikhail, Valovirta, Erkka, Van Eerd, Michiel, Van Ganse, Eric, Vasankari, Tuula, Vichyanond, Pakit, Viegi, Giovanni, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wong, Gary, Worm, Margitta, Yusuf, Osman M., Zaitoun, Fares, and Zidarn, Mihaela

Published
2024
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6. Author Correction: Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19

Author

Radzikowska, Urszula, Eljaszewicz, Andrzej, Tan, Ge, Stocker, Nino, Heider, Anja, Westermann, Patrick, Steiner, Silvio, Dreher, Anita, Wawrzyniak, Paulina, Rückert, Beate, Rodriguez-Coira, Juan, Zhakparov, Damir, Huang, Mengting, Jakiela, Bogdan, Sanak, Marek, Moniuszko, Marcin, O’Mahony, Liam, Jutel, Marek, Kebadze, Tatiana, Jackson, David J., Edwards, Michael R., Thiel, Volker, Johnston, Sebastian L., Akdis, Cezmi A., and Sokolowska, Milena

Published
2023
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7. Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19

Author

Radzikowska, Urszula, Eljaszewicz, Andrzej, Tan, Ge, Stocker, Nino, Heider, Anja, Westermann, Patrick, Steiner, Silvio, Dreher, Anita, Wawrzyniak, Paulina, Rückert, Beate, Rodriguez-Coira, Juan, Zhakparov, Damir, Huang, Mengting, Jakiela, Bogdan, Sanak, Marek, Moniuszko, Marcin, O’Mahony, Liam, Jutel, Marek, Kebadze, Tatiana, Jackson, David J., Edwards, Michael R., Thiel, Volker, Johnston, Sebastian L., Akdis, Cezmi A., and Sokolowska, Milena

Published
2023
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9. Circulating Hematopoietic (HSC) and Very-Small Embryonic like (VSEL) Stem Cells in Newly Diagnosed Childhood Diabetes type 1 – Novel Parameters of Beta Cell Destruction/Regeneration Balance and Possible Prognostic Factors of Future Disease Course

Author

Jamiołkowska-Sztabkowska, Milena, Grubczak, Kamil, Starosz, Aleksandra, Krętowska-Grunwald, Anna, Krętowska, Magdalena, Parfienowicz, Zuzanna, Moniuszko, Marcin, Bossowski, Artur, and Głowińska-Olszewska, Barbara

Published
2022
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11. Mesenchymal stromal cells effectively limit house dust mite extract‐induced mixed granulocytic lung inflammation.

Author

Tynecka, Marlena, Janucik, Adrian, Tarasik, Agnieszka, Zbikowski, Arkadiusz, Niemira, Magdalena, Kulczynska‐Przybik, Agnieszka, Zeller, Anna, Stocker, Nino, Reszec‐Gielazyn, Joanna, Mroczko, Barbara, Kretowski, Adam, Akdis, Cezmi A., Sokolowska, Milena, Moniuszko, Marcin, and Eljaszewicz, Andrzej

Subjects
SCIENCE journalism, CYTOLOGY, REGULATORY T cells, TIGHT junctions, T helper cells, PULMONARY alveolar proteinosis, ADIPOSE tissue diseases
Abstract

The article discusses the use of mesenchymal stromal cells (MSCs) in limiting house dust mite extract-induced mixed granulocytic lung inflammation in an experimental asthma model. The study found that intranasal administration of adipose tissue-derived MSCs reduced lung leukocyte infiltration, eosinophil and neutrophil counts, and altered gene expression related to inflammation. Additionally, MSCs were effective in reducing subepithelial collagen deposition and changing T effector cell responses. Further research is needed to fully understand the long-term effects of MSC transplantation in non-T2-driven asthmatic inflammation. [Extracted from the article]

Published
2024
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12. Selected stem cell populations in pediatric acute lymphoblastic leukemia.

Author

Krȩtowska-Grunwald, Anna, Sawicka-Żukowska, Małgorzata, Starosz, Aleksandra, Krawczuk-Rybak, Maryna, Moniuszko, Marcin, and Grubczak, Kamil

Subjects
STROMAL cell-derived factor 1, HEMATOPOIETIC stem cells, LYMPHOBLASTIC leukemia, STEM cells, CELL populations
Abstract

Introduction: Acute lymphoblastic leukemia is characterized by a disturbed maturation of hematopoietic stem cells (HSCs) resulting in development of a malignant clone. Despite relatively positive outcome, there are still instances of disease relapse occurring due to ineffective disease eradication or primary leukemic clone alterations. Unclear significance of stem cells in the course of ALL led us to investigate and establish crucial changes in two stem cell populations - very small embryonic-like stem cells (VSELs) and HSCs during the induction phase of treatment. Methods: In a retrospective study selected stem cells in peripheral blood and bone marrow of 60 pediatric ALL subjects and 48 healthy controls were subjected to flow cytometric analysis at 4 different time points. Results: Both VSELs and HSCs were elevated at the moment of ALL diagnosis compared to healthy controls, but profoundly decline until day 15. Further observations revealed an increase in HSCs with a concomitant depletion of VSELs until week 12. ALL patients with high HSCs showed positive correlation with bone marrow blasts at diagnosis. Patients with lower VSELs or HSCs at diagnosis had slightly improved response to applied therapy. We observed higher initial bone marrow lymphoblast values in patients with lower VSELs or higher HSCs in the high-risk group. The significance of VSELs in predicting treatment outcome can be illustrated by lower day 15 MRD level of patients with lower VSELs at diagnosis. ȩ Discussion: We found HSCs and VSELs to be valid participants in pediatric ALL with possible contribution in the neoplastic process and prediction of initial treatment outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Effect of methimazole treatment on Th1, Th17, and Th22 lymphocytes in pediatric Graves' disease patients.

Author

Starosz, Aleksandra, Stożek, Karolina, Opęchowska, Aleksandra, Bossowski, Filip, Moniuszko, Marcin, Grubczak, Kamil, and Bossowski, Artur

Subjects
GRAVES' disease, TH1 cells, T cells, STILL'S disease, GROWTH of children
Abstract

Graves' disease is the leading cause of autoimmune hyperthyroidism. Thyroid hormones are an essential element of the endocrine system, playing a pivotal role in the body's development, especially important in children with intensified growth. Disturbance within thyroid tissue certainly affected the whole body. Nowadays, numerous research studies indicate different factors contributing to the onset of the disease; however, the exact pathomechanism of Graves' disease is still not fully understood, especially in the context of immune-related processes. Th1, Th17, and Th22 effector lymphocytes were found to be crucial participants in the disease outcome, as well as in autoimmune diseases. Here, our study aimed at assessing selected effector T lymphocytes, Th1, Th17, and Th22, in newly diagnosed pediatric Graves' disease patients, together with their association with thyroid-related parameters and the potential outcome of disease management. We indicated significant increases in the frequencies and absolute numbers of selected effector lymphocytes in Graves' disease patients. In addition, their mutual ratios, as well as Th1/Th17, Th/Th22, and Th17/Th22, seem to be significant in those diseases. Notably, low Th17/Th22 ratio values were distinguished as potential prognostic factors for normalizing TSH levels in response to methimazole treatment. To sum up, our research determines the crucial contribution of Th1, Th17, and Th22 cells in the pathogenesis of Graves' disease. Moreover, the mentioned subset of T cells is highly likely to play a substantial role in the potential prediction of therapy outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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14. First insight about the ability of specific glycerophospholipids to discriminate non-small cell lung cancer subtypes

Author

Sieminska, Julia, primary, Miniewska, Katarzyna, additional, Mroz, Robert, additional, Sierko, Ewa, additional, Naumnik, Wojciech, additional, Kisluk, Joanna, additional, Michalska-Falkowska, Anna, additional, Reszec, Joanna, additional, Kozlowski, Miroslaw, additional, Nowicki, Lukasz, additional, Moniuszko, Marcin, additional, Kretowski, Adam, additional, Niklinski, Jacek, additional, Ciborowski, Michal, additional, and Godzien, Joanna, additional

Published
2024
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15. Loss of regulatory capacity in Treg cells following rhinovirus infection

Author

Jansen, Kirstin, Wirz, Oliver F., van de Veen, Willem, Tan, Ge, Mirer, David, Sokolowska, Milena, Satitsuksanoa, Pattraporn, Message, Simon D., Kebadze, Tatiana, Glanville, Nicholas, Mallia, Patrick, Skiepko, Roman, Eljaszewicz, Andrzej, Moniuszko, Marcin, Cardoso, Carlos, Gern, James E., Papadopoulos, Nikolaos G., Akdis, Cezmi A., Johnston, Sebastian L., Nadeau, Kari C., and Akdis, Mübeccel

Published
2021
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19. Surgical Treatment of Wounds Using Stem Cells in Epidermolysis Bullosa (EB)

Author

Nita, Magdalena, primary, Pliszczyński, Jacek, additional, Eljaszewicz, Andrzej, additional, Moniuszko, Marcin, additional, Ołdak, Tomasz, additional, Woźniak, Katarzyna, additional, Majewski, Sławomir, additional, Kowalewski, Cezary, additional, Kamiński, Artur, additional, Śladowski, Dariusz, additional, Zimek, Zbigniew, additional, Kosieradzki, Maciej, additional, and Fiedor, Piotr, additional

Published
2021
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20. The Proapoptotic Action of Pyrrolidinedione–Thiazolidinone Hybrids towards Human Breast Carcinoma Cells Does Not Depend on Their Genotype.

Author

Finiuk, Nataliya, Kozak, Yuliia, Gornowicz, Agnieszka, Czarnomysy, Robert, Tynecka, Marlena, Holota, Serhii, Moniuszko, Marcin, Stoika, Rostyslav, Lesyk, Roman, Bielawski, Krzysztof, and Bielawska, Anna

Subjects
HETEROCYCLIC compounds, FLOW cytometry, LIGANDS (Biochemistry), RESEARCH funding, MITOCHONDRIA, AUTOPHAGY, BREAST tumors, ANTINEOPLASTIC agents, ENZYME-linked immunosorbent assay, POLYMERASE chain reaction, APOPTOSIS, DNA, CELLULAR signal transduction, CELL lines, MICE, DOSE-effect relationship in pharmacology, MEMBRANE potential, IMMUNOHISTOCHEMISTRY, MOLECULAR structure, ANIMAL experimentation, GENOTYPES, CASPASES, PHARMACODYNAMICS
Abstract

Simple Summary: Breast cancer is one of the most frequent tumors worldwide, based on the number of new cases and deaths. Unfortunately, the low selectivity of action and the rapid development of multiple drug resistances remain the main disadvantages of anticancer compounds. The search for new agents with pronounced antitumor activity is an urgent task in modern biology and medicine. We focused on the investigation of the antitumor potential of novel hybrid pyrrolidinedione–thiazolidinone derivatives. The synthesized derivatives are effective and selective agents that exhibit their antitumor effects in breast carcinoma cells via (1) inhibiting viability, proliferation, and the ability to form colonies; (2) inducing extrinsic and intrinsic apoptotic pathways; and (3) decreasing the level of proteins associated with autophagy, invasion, and metastasis. Our results indicate that synthesized derivatives are potential candidates for deeper exploration of their therapeutic efficiency. The development of new, effective agents for the treatment of breast cancer remains a high-priority task in oncology. A strategy of treatment for this pathology depends significantly on the genotype and phenotype of human breast cancer cells. We aimed to investigate the antitumor activity of new pyrrolidinedione–thiazolidinone hybrid molecules Les-6287, Les-6294, and Les-6328 towards different types of human breast cancer cells of MDA-MB-231, MCF-7, T-47D, and HCC1954 lines and murine breast cancer 4T1 cells by using the MTT, clonogenic and [3H]-Thymidine incorporation assays, flow cytometry, ELISA, and qPCR. The studied hybrids possessed toxicity towards the mentioned tumor cells, with the IC50 ranging from 1.37 to 21.85 µM. Simultaneously, these derivatives showed low toxicity towards the pseudonormal human breast epithelial cells of the MCF-10A line (IC50 > 93.01 µM). Les-6287 at 1 µM fully inhibited the formation of colonies of the MCF-7, MDA-MB-231, and HCC1954 cells, while Les-6294 and Les-6328 did that at 2.5 and 5 µM, respectively. Les-6287 suppressed DNA biosynthesis in the MCF-7, MDA-MB-231, and HCC1954 cells. At the same time, such an effect on the MCF-10A cells was significantly lower. Les-6287 induces apoptosis using extrinsic and intrinsic pathways via a decrease in the mitochondrial membrane potential, increasing the activity of caspases 3/7, 8, 9, and 10 in all immunohistochemically different human breast cancer cells. Les-6287 decreased the concentration of the metastasis- and invasion-related proteins MMP-2, MMP-9, and ICAM-1. It did not induce autophagy in treated cells. In conclusion, the results of our study suggest that the synthesized hybrid pyrrolidinedione–thiazolidinones might be promising agents for treating breast tumors of different types. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Cardiovascular risk and the COVID-19 pandemic: a population-based and case‒control studies.

Author

Chlabicz, Małgorzata, Jamiołkowski, Jacek, Dubatówka, Marlena, Sołomacha, Sebastian, Chlabicz, Magdalena, Zieleniewska, Natalia, Sowa, Paweł, Szpakowicz, Anna, Moniuszko-Malinowska, Anna M., Flisiak, Robert, Moniuszko, Marcin, and Kamiński, Karol A.

Subjects
CARDIOVASCULAR disease prevention, HDL cholesterol, PHOTON absorptiometry, MEDICAL protocols, RESEARCH funding, CARDIOLOGY, T-test (Statistics), STATISTICAL sampling, GLUCOSE tolerance tests, COVID-19 testing, QUESTIONNAIRES, FISHER exact test, CARDIOVASCULAR diseases risk factors, LDL cholesterol, DESCRIPTIVE statistics, REVERSE transcriptase polymerase chain reaction, DISEASE prevalence, MANN Whitney U Test, CHI-squared test, ODDS ratio, CASE-control method, STATISTICS, NASOPHARYNX, DATA analysis software, COMPARATIVE studies, ANTHROPOMETRY, CONFIDENCE intervals, COVID-19 pandemic, COVID-19, GLOMERULAR filtration rate
Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic is associated with increases in morbidity and mortality worldwide. The mechanisms of how SARS-CoV-2 may cause cardiovascular (CV) complications are under investigation. The aim of the study was to assess the impact of the COVID-19 pandemic on CV risk. Methods: These are single-centre Bialystok PLUS (Poland) population-based and case‒control studies. The survey was conducted between 2018 and 2022 on a sample of residents (n = 1507) of a large city in central Europe and patients 6–9 months post-COVID-19 infection (n = 126). The Systematic Coronary Risk Estimation 2 (SCORE2), the Systematic Coronary Risk Estimation 2-Older Persons (SCORE2-OP), the Cardiovascular Disease Framingham Heart Study and the LIFEtime-perspective model for individualizing CardioVascular Disease prevention strategies in apparently healthy people (LIFE-CVD) were used. Subsequently, the study populations were divided into CV risk classes according to the 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Results: The study population consisted of 4 groups: a general population examined before (I, n = 691) and during the COVID-19 pandemic (II, n = 816); a group of 126 patients post-COVID-19 infection (III); and a control group matched subjects chosen from the pre-COVID-19 pandemic (IV). Group II was characterized by lower blood pressure, low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) values than group I. Group III differed from the control group in terms of lower LDL-c level. There was no effect on CV risk in the general population, but in the population post-COVID-19 infection, CV risk was lower using FS-lipids, FS-BMI and LIFE-CVD 10-year risk scores compared to the prepandemic population. In all subgroups analysed, no statistically significant difference was found in the frequency of CV risk classes. Conclusions: The COVID-19 pandemic did not increase the CV risk calculated for primary prevention. Instead, it prompted people to pay attention to their health status, as evidenced by better control of some CV risk factors. As the COVID-19 pandemic has drawn people's attention to health, it is worth exploiting this opportunity to improve public health knowledge through the design of wide-ranging information campaigns. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Circulating serum miR-362-3p and miR-6721-5p as potential biomarkers for classification patients with adult-type diffuse glioma

Author

Niemira, Magdalena, primary, Bielska, Agnieszka, additional, Chwialkowska, Karolina, additional, Raczkowska, Justyna, additional, Skwarska, Anna, additional, Erol, Anna, additional, Zeller, Anna, additional, Sokolowska, Gabriela, additional, Toczydlowski, Damian, additional, Sidorkiewicz, Iwona, additional, Mariak, Zenon, additional, Reszec, Joanna, additional, Lyson, Tomasz, additional, Moniuszko, Marcin, additional, and Kretowski, Adam, additional

Published
2024
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25. Exploration of oxidized phosphocholine profile in non-small-cell lung cancer

Author

Godzien, Joanna, primary, Lopez-Lopez, Angeles, additional, Sieminska, Julia, additional, Jablonowski, Kacper, additional, Pietrowska, Karolina, additional, Kisluk, Joanna, additional, Mojsak, Malgorzata, additional, Dzieciol-Anikiej, Zofia, additional, Barbas, Coral, additional, Reszec, Joanna, additional, Kozlowski, Miroslaw, additional, Moniuszko, Marcin, additional, Kretowski, Adam, additional, Niklinski, Jacek, additional, and Ciborowski, Michal, additional

Published
2024
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28. Stanowisko grupy ekspertów Polskiego towarzystwa Alergologicznego w sprawie postępowania u chorych na astmę i choroby alergiczne w okresie pandemii SARS-coV-2.

Author

Kowalski, Marek L., Bartuzi, Zbigniew, Bręborowicz, Anna, Czarnecka-Operacz, Magdalena, Kruszewski, Jerzy, Kulus, Marek, Moniuszko, Marcin, Niedoszytko, Marek, Nittner-Marszalska, Marita, Nowicki, Roman J., Rogala, Barbara, and Chałubiński, Maciej

Subjects
ASTHMA treatment, ADRENOCORTICAL hormones, ALLERGENS, IMMUNOTHERAPY, ALLERGIES, INTERNET, IMMUNOLOGY, ALLERGISTS, PATIENT care, COMMUNICATION, TELEPHONES, DISEASE susceptibility, INTERPERSONAL relations, COVID-19 pandemic
Abstract

Copyright of Polish Journal of Allergology / Alergologia Polska is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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29. The Association between Immune Checkpoint Proteins and Therapy Outcomes in Acute Myeloid Leukaemia Patients

Author

Bolkun, Lukasz, primary, Tynecka, Marlena, additional, Walewska, Alicja, additional, Bernatowicz, Malgorzata, additional, Piszcz, Jaroslaw, additional, Cichocka, Edyta, additional, Wandtke, Tomasz, additional, Czemerska, Magdalena, additional, Wierzbowska, Agnieszka, additional, Moniuszko, Marcin, additional, Grubczak, Kamil, additional, and Eljaszewicz, Andrzej, additional

Published
2023
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31. Management of Progressive Pulmonary Nodules Found during and outside of CT Lung Cancer Screening Studies

Author

Meyer, Mathias, Vliegenthart, Rozemarijn, Henzler, Thomas, Buergy, Daniel, Giordano, Frank A., Kostrzewa, Michael, Rathmann, Nils, Brustugun, Odd Terje, Crino, Lucio, Dingemans, Anne-Marie C., Dusmet, Michael, Fennell, Dean, Grunenwald, Dominique, Huber, Rudolf Maria, Moniuszko, Marcin, Mornex, Francoise, Papotti, Mauro, Pilz, Lothar, Senan, Suresh, Syrigos, Kostas, Pérol, Maurice, Gray, Jhanelle E., Schabel, Christoph, van Meerbeeck, Jan P., van Zandwijk, Nico, Zhou, Cai Cun, Manegold, Christian, Voigt, Wieland, and Roessner, Eric Dominic

Published
2017
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33. A comparison of different machine-learning techniques for the selection of a panel of metabolites allowing early detection of brain tumors

Author

Godlewski, Adrian, primary, Czajkowski, Marcin, additional, Mojsak, Patrycja, additional, Pienkowski, Tomasz, additional, Gosk, Wioleta, additional, Lyson, Tomasz, additional, Mariak, Zenon, additional, Reszec, Joanna, additional, Kondraciuk, Marcin, additional, Kaminski, Karol, additional, Kretowski, Marek, additional, Moniuszko, Marcin, additional, Kretowski, Adam, additional, and Ciborowski, Michal, additional

Published
2023
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35. Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy: The Polish MOBIT project

Author

Niklinski, Jacek, Kretowski, Adam, Moniuszko, Marcin, Reszec, Joanna, Michalska-Falkowska, Anna, Niemira, Magdalena, Ciborowski, Michal, Charkiewicz, Radoslaw, Jurgilewicz, Dorota, Kozlowski, Miroslaw, Ramlau, Rodryg, Piwkowski, Cezary, Kwasniewski, Miroslaw, Kaczmarek, Monika, Ciereszko, Andrzej, Wasniewski, Tomasz, Mroz, Robert, Naumnik, Wojciech, Sierko, Ewa, Paczkowska, Magdalena, Kisluk, Joanna, Sulewska, Anetta, Cybulski, Adam, Mariak, Zenon, Kedra, Boguslaw, Szamatowicz, Jacek, Kurzawa, Paweł, Minarowski, Lukasz, Charkiewicz, Angelika Edyta, Mroczko, Barbara, Malyszko, Jolanta, Manegold, Christian, Pilz, Lothar, Allgayer, Heike, Abba, Mohammed L., Juhl, Hartmut, and Koch, Frauke

Published
2017
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37. The Potential of Combined Immunotherapy and Antiangiogenesis for the Synergistic Treatment of Advanced NSCLC

Author

Manegold, Christian, Dingemans, Anne-Marie C., Gray, Jhanelle E., Nakagawa, Kazuhiko, Nicolson, Marianne, Peters, Solange, Reck, Martin, Wu, Yi-Long, Brustugun, Odd Terje, Crinò, Lucio, Felip, Enriqueta, Fennell, Dean, Garrido, Pilar, Huber, Rudolf M., Marabelle, Aurélien, Moniuszko, Marcin, Mornex, Françoise, Novello, Silvia, Papotti, Mauro, Pérol, Maurice, Smit, Egbert F., Syrigos, Kostas, van Meerbeeck, Jan P., van Zandwijk, Nico, Chih-Hsin Yang, James, Zhou, Caicun, and Vokes, Everett

Published
2017
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39. Alterations in Stem Cell Populations in IGF-1 Deficient Pediatric Patients Subjected to Mecasermin (Increlex) Treatment

Author

Grubczak Kamil, Stożek Karolina, Starosz Aleksandra, Bossowski Filip, Pasławska Marta, Bossowski Artur, and Moniuszko Marcin

Subjects
General Medicine
Abstract

Pathway involving insulin-like growth factor 1 (IGF-1) plays significant role in growth and development. Crucial role of IGF-1 was discovered inter alia through studies involving deficient patients with short stature, including Laron syndrome individuals. Noteworthy, despite disturbances in proper growth, elevated values for selected stem cell populations were found in IGF-1 deficient patients. Therefore, here we focused on investigating role of these cells—very small embryonic-like (VSEL) and hematopoietic stem cells (HSC), in the pathology. For the first time we performed long-term observation of these populations in response to rhIGF-1 (mecasermin) therapy. Enrolled pediatric subjects with IGF-1 deficiency syndrome were monitored for 4–5 years of rhIGF-1 treatment. Selected stem cells were analyzed in peripheral blood flow cytometrically, together with chemoattractant SDF-1 using immunoenzymatic method. Patients’ data were collected for correlation of experimental results with clinical outcome. IGF-1 deficient patients were found to demonstrate initially higher levels of VSEL and HSC compared to healthy controls, with their gradual decrease in response to therapy. These changes were significantly associated with SDF-1 plasma levels. Correlations of VSEL and HSC were also reported in reference to growth-related parameters, and IGF-1 and IGFBP3 values. Noteworthy, rhIGF-1 was shown to efficiently induce development of Laron patients achieving at least proper rate of growth (compared to healthy group) in 80% of subjects. In conclusion, here we provided novel insight into stem cells participation in IGF-1 deficiency in patients. Thus, we demonstrated basis for future studies in context of stem cells and IGF-1 role in growth disturbances. Graphical abstract

Published
2022

42. Excessive BMI is associated with higher C-peptide level at recognition but also with its greater loss in two years clinical observation in children with new onset type 1 diabetes

Author

Kurpiewska, Emilia, primary, Ciężki, Sebastian, additional, Jamiołkowska-Sztabkowska, Milena, additional, Polkowska, Agnieszka, additional, Starosz, Aleksandra, additional, Grubczak, Kamil, additional, Moniuszko, Marcin, additional, Bossowski, Artur, additional, and Głowińska-Olszewska, Barbara, additional

Published
2023
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43. Alpha-Synuclein mRNA Level Found Dependent on L444P Variant in Carriers and Gaucher Disease Patients on Enzyme Replacement Therapy

Author

Dubiela, Paweł, primary, Szymańska-Rożek, Paulina, additional, Eljaszewicz, Andrzej, additional, Lipiński, Patryk, additional, Hasiński, Piotr, additional, Giersz, Dorota, additional, Walewska, Alicja, additional, Tynecka, Marlena, additional, Moniuszko, Marcin, additional, and Tylki-Szymańska, Anna, additional

Published
2023
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44. Rhinovirus-induced epithelial RIG-I inflammasome suppresses antiviral immunity and promotes inflammation in asthma and COVID-19

Author

Radzikowska, Urszula; https://orcid.org/0000-0002-7341-9764, Eljaszewicz, Andrzej; https://orcid.org/0000-0002-8980-1474, Tan, Ge; https://orcid.org/0000-0003-0026-8739, Stocker, Nino, Heider, Anja; https://orcid.org/0000-0002-3448-4125, Westermann, Patrick; https://orcid.org/0000-0003-2894-6140, Steiner, Silvio; https://orcid.org/0000-0003-1999-1425, Dreher, Anita, Wawrzyniak, Paulina; https://orcid.org/0000-0001-9641-2103, Rückert, Beate; https://orcid.org/0000-0003-1804-1698, Rodriguez-Coira, Juan, Zhakparov, Damir, Huang, Mengting, Jakiela, Bogdan; https://orcid.org/0000-0003-0444-981X, Sanak, Marek; https://orcid.org/0000-0001-7635-8103, Moniuszko, Marcin; https://orcid.org/0000-0001-7183-3120, O’Mahony, Liam; https://orcid.org/0000-0003-4705-3583, Jutel, Marek, Kebadze, Tatiana, Jackson, David J, Edwards, Michael R, Thiel, Volker; https://orcid.org/0000-0002-5783-0887, Johnston, Sebastian L; https://orcid.org/0000-0003-3009-9200, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Sokolowska, Milena; https://orcid.org/0000-0001-9710-6685, Radzikowska, Urszula; https://orcid.org/0000-0002-7341-9764, Eljaszewicz, Andrzej; https://orcid.org/0000-0002-8980-1474, Tan, Ge; https://orcid.org/0000-0003-0026-8739, Stocker, Nino, Heider, Anja; https://orcid.org/0000-0002-3448-4125, Westermann, Patrick; https://orcid.org/0000-0003-2894-6140, Steiner, Silvio; https://orcid.org/0000-0003-1999-1425, Dreher, Anita, Wawrzyniak, Paulina; https://orcid.org/0000-0001-9641-2103, Rückert, Beate; https://orcid.org/0000-0003-1804-1698, Rodriguez-Coira, Juan, Zhakparov, Damir, Huang, Mengting, Jakiela, Bogdan; https://orcid.org/0000-0003-0444-981X, Sanak, Marek; https://orcid.org/0000-0001-7635-8103, Moniuszko, Marcin; https://orcid.org/0000-0001-7183-3120, O’Mahony, Liam; https://orcid.org/0000-0003-4705-3583, Jutel, Marek, Kebadze, Tatiana, Jackson, David J, Edwards, Michael R, Thiel, Volker; https://orcid.org/0000-0002-5783-0887, Johnston, Sebastian L; https://orcid.org/0000-0003-3009-9200, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, and Sokolowska, Milena; https://orcid.org/0000-0001-9710-6685

Abstract

Rhinoviruses and allergens, such as house dust mite are major agents responsible for asthma exacerbations. The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. We analyse mechanisms of response to viral infection in experimental in vivo rhinovirus infection in healthy controls and patients with asthma, and in in vitro experiments with house dust mite, rhinovirus and SARS-CoV-2 in human primary airway epithelium. Here, we show that rhinovirus infection in patients with asthma leads to an excessive RIG-I inflammasome activation, which diminishes its accessibility for type I/III interferon responses, leading to their early functional impairment, delayed resolution, prolonged viral clearance and unresolved inflammation in vitro and in vivo. Pre-exposure to house dust mite augments this phenomenon by inflammasome priming and auxiliary inhibition of early type I/III interferon responses. Prior infection with rhinovirus followed by SARS-CoV-2 infection augments RIG-I inflammasome activation and epithelial inflammation. Timely inhibition of the epithelial RIG-I inflammasome may lead to more efficient viral clearance and lower the burden of rhinovirus and SARS-CoV-2 infections.

Published
2023

50. Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Author

Bousquet, Jean, Melén, Erik, Haahtela, Tari, Koppelman, Gerard, Togias, Alkis, Valenta, Rudolf, Akdis, Cezmi, Czarlewski, Wienczyslawa, Rothenberg, Marc, Valiulis, Arunas, Wickman, Magnus, Vichyanond, Pakit, Moniuszko, Marcin, Ėmužytė, Regina, Bush, Andrew, Chu, Derek K, Viegi, Giovanni, Wallace, Dana, Durham, Stephen, Wang, De Yun, Vandenplas, O., Just, Jocelyne, Carlsen, Karin C. Lodrup, Passalacqua, Giovanni, Williams, Siân, Linnemann, Désirée Larenas, Loureiro, Cláudia Chaves, Sagara, Hironori, Worm, Margitta, Yiallouros, Panayiotis, Yusuf, Osman, Zaitoun, Fares, Bonini, Matteo, Hrubiško, Martin, Cingi, C., Dykewicz, Mark, Zernotti, Mario, Calderon, Moises, Halpin, David M.G., Zidarn, Mihaela, Patella, Vincenzo, Sheikh, Aziz, Zuberbier, Jaron, Papadopoulos, Nikolaos, Louis, Renaud, Suppli Ulrik, Charlotte, Fonseca, João P., Zuberbier, Torsten, Anto, M. J., Costa, Elisio, Eiwegger, Thomas, Bosnic-Anticevich, Sinthia, Cruz, Alvaro, Sousa, Jaime Correia de, Louis-Philippe, Boulet, Erhola, Marina, Cardona, Victoria, Carr, Warner, Gemicioglu, Bilun, Pawankar, Ruby, Fokkens, Wytske, Calvo, Mário, Garcia-Aymerich, J., Mäkelä, Mika J., Hofmann, Maja Ann, Klimek, Ludger, Makris, Michael, Mohamed Sayed, Zeinab, Maurer, Marcus, D'Amato, G., Momas, Isabelle, Siroux, Valérie, Almeida, Mário Morais, Corrigan, Chris, Mullol, Joaquim, Montefort, Stephen, Jutel, Marek, Pham Thi, Nhan, Hossny, Elham, Akdis, Mubeccel, Pfaar, Oliver, Ventura, Maria Teresa, Regateiro, Frederico S., Bindslev-Jensen, Carsten, Ring, Johannes, Bustamante, Mariona, Pinto, Bernardo Sousa, Kaidashev, Igor, Guerra, Stefano, Standl, Marie, Sunyer, J., Keil, Thomas, Barata, Luís Taborda, Camargos, Paulo, Weiss, Scott, Naclerio, Robert, Yorgancıoglu, Arzu, Zhang, Luo, Nadeau, Kari, Abdul Latiff, Amir, Aberer, Werner, Heinrich, Joachim, Sisul, Juan, Nunes, Elizabete, Plavec, Davor, Agache, Ioana, Al-Ahmad, Mona, Serpa, Faradiba, Alobid, Isam, Kalayci, Omer, Giacco, S. Del, Fiocchi, Alessandro, Ansotegui Zubeldia, Ignacio Javier, Custovic, Adnan, Martins, Pedro Carreiro, Rouadi, Philip, Arshad, Syed Hasan, Asayag, Estrella, Bárbara, Cristina, Abdullah, Baharudin, Tomazic, Peter Valentin, Popov, T. A., Sayah, Zineb, Lkhagvaa, Battur, Nyembue Tshipukane , Dieudonne, Thomas, Mike, Bennoor, Kazi Saifuddin, Fyhrquist, Nanna Theresia, Irani, Carla, Berghea, Elena Camelia, De Blay, Frédéric, Toppila-Salmi, Sanna Katriina, Bergmann, Karl-Christian, Bernstein, D., Bewick, M., Casale, Thomas, Scheire, Sophie, Bumbacea, Roxana Silvia, Cepeda Sarabia, Alfonso, Puggioni, Francesca, Chandrasekharan, Ramanathan, Ohta, Ken, Okubo, Kimihiro, Charpin, Denis, Gomez, R Maximiliano, Chen, Y. Z., O'Hehir, Robyn, Cherrez Ojeda, Ivan, Bedbrook, Anna, To, Teresa, Devillier, Philippe, Schmid-Grendelmeier, Peter, Didier, Alain, Repka-Ramirez, María Susana, Teixeira, Maria Do Céu, Ispayeva, Zhanat, Dokic, Dejan, Quirce, Santiago, Douagui , Habib, Ivancevich, Juan Carlos, Gotua, Maia, Todo-Bom, Ana, Blain, Hubert, Guzman, Maria Antonieta, Kalyoncu, Ali Fuat, Hagemann, Jan, Buhl, Roland, Hamamah, Samir, Caraballo, Luis, Jares, Edgardo, Chivato, Tomás, Jartti, Tuomas, Jassem, Ewa, Christoff, George, Julge, Kalev, Ogulur, Ismail, Kardas, Przemyslaw, Doulaptsi, Maria, Kirenga, Bruce, Helga, Kraxner, Kull, Inger, Kulus, Marek, Daniel, Aguilar, Shamji, Mohamed, Kuna, Piotr, Nadif, Rachel, La Grutta, Stefania, Brightling, Chris, Samoliński, Bolesław, Lau, Susanne, Cordeiro, Carlos Manuel Da Silva Robalo, Solé, Dirceu, Le Thi Tuyet, Lan, Recto, Marysia, Ouedraogo, Solange, Halken, Susanne, Levin, Michael, Lipworth, Brian, Lourenço, Olga, Mahboub, Bassam, Niedoszytko, Marek, Sastre, Joaquin, Martinez‐Infante, E., Kupczyk, Maciej, Torres, María Jose, Matricardi, Paolo Maria, Cecchi, Lorenzo, Celedón, Juan C, Miculinic, Neven, Roche, Nicolas, Migueres, Nicolas, Brussino, Luisa, Florin, Mihaltan, Olze, Heidi, Savouré, Marine, Nekam, Kristof, Pali, Isabella, Okamoto, Yoshitaka, Palomares, O., Lemonnier, Nathanaël, Palosuo, Kati, Soto-Martinez, Manuel, Panaitescu, Carmen, Kvedarienė, Violeta, Panzner, P., Braido, Fulvio, Tsiligianni, Ioanna, Rodriguez-Gonzalez, Monica, Scichilone, Nicola, Canonica, Giogio Walter, Romantowski, Jan, Urrutia-Pereira, Marilyn, Filho, Nelson Augusto Rosario, Ollert, Markus W., Rottem, Menachem, Chkhartishvili, Ekaterine, Sova, Milan, Valovirta, Erkka, Mohammad, Yousser, Sperl, Annette, Spranger, Otto, Neffen, Hugo, Stelmach, Rafael, Burte, Emilie, Valentin Rostan, Marylin, Park, Hae-Sim, Van Ganse, Eric, Van Hage, Marianne, Pitsios, Constantinos, Vasankari, Tuula, and uBibliorum

Subjects
IL-33, Multimorbidity, Asthma, Toll-like receptors, Rhinitis
Abstract

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.

Published
2023

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