Mesenchymal stromal cells effectively limit house dust mite extract‐induced mixed granulocytic lung inflammation.

The article discusses the use of mesenchymal stromal cells (MSCs) in limiting house dust mite extract-induced mixed granulocytic lung inflammation in an experimental asthma model. The study found that intranasal administration of adipose tissue-derived MSCs reduced lung leukocyte infiltration, eosinophil and neutrophil counts, and altered gene expression related to inflammation. Additionally, MSCs were effective in reducing subepithelial collagen deposition and changing T effector cell responses. Further research is needed to fully understand the long-term effects of MSC transplantation in non-T2-driven asthmatic inflammation. [Extracted from the article]