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3. Addressing the unsolved challenges in microRNA-based biomarker development: Suitable endogenous reference microRNAs for SARS-CoV-2 infection severity

Author

Belmonte, Thalia, Perez-Pons, Manel, Benítez, Iván D., Molinero, Marta, García-Hidalgo, María C., Rodríguez-Muñoz, Carlos, Gort-Paniello, Clara, Moncusí-Moix, Anna, Madè, Alisia, Devaux, Yvan, Martelli, Fabio, Ortega, Alicia, González, Jessica, Torres, Gerard, Barbé, Ferran, and de Gonzalo-Calvo, David

Published
2024
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5. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author

Cabello, María Aguilar, Alcaraz-Serrano, Victoria, Aldecoa, Cesar, Alegre, Cynthia, Calderón, Ángela Algaba, Álvarez, Sergio, Ruiz, Antonio Álvarez, Andrea, Ruth, Aparicio, Maria de Alba, Arrieta, Marta, Ayestarán, J. Ignacio, Badia, Joan Ramon, Badía, Mariona, Pravia, Orville Báez, Mariño, Ana Balan, Balsera, Begoña, Barbena, Laura, Barbeta, Enric, Bardi, Tommaso, Segade, Patricia Barral, Barroso, Marta, García, José Ángel Berezo, Bermejo, Jesus, Bigas, Judit, Blancas, Rafael, Cortés, María Luisa Blasco, Saera, María Bodi, Bofill, Neus, Vieiro, María Teresa Bouza, Bueno, Leticia, Bustamante-Munguira, Juan, Martínez, Cecilia del Busto, Hermoso, David Campi, Fernández, Sandra Campos, Cano, Iosune, Canseco, Joan, Fernández, Pablo Cardinal, García, Laura Carrión, Carvalho, Sulamita, Castellà, Manuel, Castellví, Andrea, Castro, Pedro, Centelles-Serrano, María José, Ávila, Ramon Cicuendez, Cillóniz, Catia, Clar, Luisa, Climent, Cristina, Codina, Jordi, Conde, Pamela, Contreras, Sofía, Parra, Raul de Frutos, Sánchez, Raul de Pablo, Mendoza, Diego De, Díaz, Yolanda, Vilas, María Digna Rivas, Moreno, Cristina Dólera, Dot, Irene, Giraudo, Pedro Enríquez, Arijón, Inés Esmorís, Monjo, Teresa Farre, Fernández, Javier, Ferrando, Carlos, Figueras, Albert, Espina, Lorena Forcelledo, Franquesa, Enric, Furro, Àngels, Gabarrus, Albert, Galbán, Cristóbal, García, Felipe, García, Beatriz, Prieto, Emilio García, Redruello, Carlos García, Sagastume, Amaia García, Castillo, Maria Luisa Gascón, Gomà, Gemma, Casal, Vanesa Gómez, Gómez, Silvia, Gonzalez, Carmen Gómez, Gordo, Federico, Gracia, Maria Pilar, Fernández, María José Gutierrez, Herraiz, Alba, Herrán-Monge, Rubén, Ibarz, Mercedes, Iglesias, Silvia, Janer, Maria Teresa, Jiménez, Gabriel, Díaz, Mar Juan, Kiarostami, Karsa, Álvarez, Juan I. Lazo, León, Miguel, López-Gavín, Alexandre, Guerrero, Desiree Macias, Herrera, Nuria Mamolar, Mendiluce, Rafael Mañez, Mantellini, Cecilia L., Naya, Gregorio Marco, Barcos, Iris Marco, Marcos, Pilar, Peis, Enrique Marmol, Cuadrado, Marta Martín, Delgado, María Cruz Martin, Vicente, Paula Martín, Martínez, María, Fernández, Carmen Eulalia Martínez, Juan, Maria Dolores Martínez, Palacios, Basilisa Martínez, Jimenez, Juan Fernando Masa, Masclans, Joan Ramon, Maseda, Emilio, Fernández, Eva María Menor, Banderas, Priscila Metora, Minguez, Olga, Miralbés, Mar, Monclou, Josman, Montejo-González, Juan Carlos, Montserrat, Neus, Aznar, María Mora, Morales, Dulce, Cano, Sara Guadalupe Moreno, Rodríguez, David Mosquera, Muñoz-Bermúdez, Rosana, Nicolás, José María, Bou, Ramon Nogue, Salinas, Rafaela Nogueras, Ocón, Marta, Ortega, Ana, Ossa, Sergio, Pagliarani, Pablo, Parrilla, Francisco, Pedregosa-Díaz, José, Bastida, Leire Pérez, Pérez, Purificación, Pérez-García, Felipe, Planelles, Gloria Pérez, Rubio, Eva Pérez, Laguna, David Pestaña, Prados, Javier, Pujol, Andrés, Coll, Núria Ramon, Sanchez-Giron, Gloria Renedo, Roche-Campo, Ferran, Rodriguez, Laura, Castro, Felipe Rodríguez de, Rodríguez, Silvia, Ruiz, Covadonga Rodríguez, Rubio, Jorge, López, Alberto Rubio, Ruiz-García, Ángela Leonor, Miralles, Miriam Ruiz, Murúa, Pablo Ryan, Paz, Eva Saborido, Degracia, Ana Salazar, Sanchez, Miguel, Sánchez, Ana, Chinesta, Susana Sancho, Santacoloma, Bitor, Sariñena, Maria Teresa, Pensado, Marta Segura, Serra, Lidia, Serra-Fortuny, Mireia, Lázaro, Ainhoa Serrano, Servià, Lluís, Soliva, Laura, Speziale, Carla, Tormos, Adrián, Torres, Mateu, Tranque-Liberal, Celia, Trefler, Sandra, Trujillano, Javier, Vaca, Rafaela, Val, Estela, Ruiz, Luis Valdivia, Vallverdú, Montserrat, Martin-Montalvo, Maria Van der Hofstadt, Adrio, Sabela Vara, Vázquez, Nil, Vengoechea, Javier, Vilà-Vilardel, Clara, Vilanova, Judit, Warrington, Tatiana Villada, Yang, Hua, Yang, Minlan, Zapatero, Ana, González, Jessica, de Batlle, Jordi, Benítez, Iván D., Torres, Gerard, Santisteve, Sally, Targa, Adriano D.S., Gort-Paniello, Clara, Moncusí-Moix, Anna, Aguilà, Maria, Seck, Fatty, Ceccato, Adrián, Ferrer, Ricard, Motos, Anna, Riera, Jordi, Fernández, Laia, Menéndez, Rosario, Lorente, José Ángel, Peñuelas, Oscar, Garcia-Gasulla, Dario, Peñasco, Yhivian, Ricart, Pilar, Abril Palomares, Elena, Aguilera, Luciano, Rodríguez, Alejandro, Boado Varela, Maria Victoria, Beteré, Belén, Pozo-Laderas, Juan Carlos, Solé-Violan, Jordi, Salvador-Adell, Inmaculada, Novo, Mariana Andrea, Barberán, José, Amaya Villar, Rosario, Garnacho-Montero, José, Gómez, José M., Blandino Ortiz, Aaron, Tamayo Lomas, Luis, Úbeda, Alejandro, Catalán-González, Mercedes, Sánchez-Miralles, Angel, Martínez Varela, Ignacio, Jorge García, Ruth Noemí, Franco, Nieves, Gumucio-Sanguino, Víctor D., Bustamante-Munguira, Elena, Valdivia, Luis Jorge, Caballero, Jesús, Gallego, Elena, Rodríguez, Covadonga, Castellanos-Ortega, Álvaro, Trenado, Josep, Marin-Corral, Judith, Albaiceta, Guillermo M., de la Torre, Maria del Carmen, Loza-Vázquez, Ana, Vidal, Pablo, Añón, Jose M., Carbajales Pérez, Cristina, Sagredo, Victor, Carbonell, Nieves, Socias, Lorenzo, Barberà, Carme, Estella, Angel, Diaz, Emili, de Gonzalo-Calvo, David, Torres, Antoni, and Barbé, Ferran

Published
2023
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6. Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infection

Author

García-Hidalgo, María C., Peláez, Rafael, González, Jessica, Santisteve, Sally, Benítez, Iván D., Molinero, Marta, Perez-Pons, Manel, Belmonte, Thalía, Torres, Gerard, Moncusí-Moix, Anna, Gort-Paniello, Clara, Aguilà, Maria, Seck, Faty, Carmona, Paola, Caballero, Jesús, Barberà, Carme, Ceccato, Adrián, Fernández-Barat, Laia, Ferrer, Ricard, Garcia-Gasulla, Dario, Lorente-Balanza, Jose Ángel, Menéndez, Rosario, Motos, Ana, Peñuelas, Oscar, Riera, Jordi, Bermejo-Martin, Jesús F., Torres, Antoni, Barbé, Ferran, de Gonzalo-Calvo, David, and Larráyoz, Ignacio M.

Published
2022
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7. Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study

Author

González, Jessica, Benítez, Iván D., de Gonzalo-Calvo, David, Torres, Gerard, de Batlle, Jordi, Gómez, Silvia, Moncusí-Moix, Anna, Carmona, Paola, Santisteve, Sally, Monge, Aida, Gort-Paniello, Clara, Zuil, María, Cabo-Gambín, Ramón, Manzano Senra, Carlos, Vengoechea Aragoncillo, José Javier, Vaca, Rafaela, Minguez, Olga, Aguilar, María, Ferrer, Ricard, Ceccato, Adrián, Fernández, Laia, Motos, Ana, Riera, Jordi, Menéndez, Rosario, Garcia-Gasulla, Darío, Peñuelas, Oscar, Labarca, Gonzalo, Caballero, Jesús, Barberà, Carme, Torres, Antoni, and Barbé, Ferran

Published
2022
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8. MicroRNA‐guided drug discovery for mitigating persistent pulmonary complications in critical COVID‐19 survivors: A longitudinal pilot study

Author

García‐Hidalgo, María C., primary, Benítez, Iván D., additional, Perez‐Pons, Manel, additional, Molinero, Marta, additional, Belmonte, Thalía, additional, Rodríguez‐Muñoz, Carlos, additional, Aguilà, María, additional, Santisteve, Sally, additional, Torres, Gerard, additional, Moncusí‐Moix, Anna, additional, Gort‐Paniello, Clara, additional, Peláez, Rafael, additional, Larráyoz, Ignacio M., additional, Caballero, Jesús, additional, Barberà, Carme, additional, Nova‐Lamperti, Estefania, additional, Torres, Antoni, additional, González, Jessica, additional, Barbé, Ferran, additional, and de Gonzalo‐Calvo, David, additional

Published
2024
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9. Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

Author

GONZALO-CALVO, DAVID de, BENÍTEZ, IVÁN D., PINILLA, LUCÍA, CARRATALÁ, AMARA, MONCUSÍ-MOIX, ANNA, GORT-PANIELLO, CLARA, MOLINERO, MARTA, GONZÁLEZ, JESSICA, TORRES, GERARD, BERNAL, MARÍA, PICO, SILVIA, ALMANSA, RAQUEL, JORGE, NOELIA, ORTEGA, ALICIA, BUSTAMANTE-MUNGUIRA, ELENA, GÓMEZ, JOSÉ MANUEL, GONZÁLEZ-RIVERA, MILAGROS, MICHELOUD, DARIELA, RYAN, PABLO, MARTINEZ, AMALIA, TAMAYO, LUIS, ALDECOA, CÉSAR, FERRER, RICARD, CECCATO, ADRIÁN, FERNÁNDEZ-BARAT, LAIA, MOTOS, ANA, RIERA, JORDI, MENÉNDEZ, ROSARIO, GARCIA-GASULLA, DARIO, PEÑUELAS, OSCAR, TORRES, ANTONI, BERMEJO-MARTIN, JESÚS F., and BARBÉ, FERRAN

Published
2021
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11. Adherence to CPAP Treatment and the Risk of Recurrent Cardiovascular Events

Author

Sánchez-de-la-Torre, Manuel, primary, Gracia-Lavedan, Esther, additional, Benitez, Ivan D., additional, Sánchez-de-la-Torre, Alicia, additional, Moncusí-Moix, Anna, additional, Torres, Gerard, additional, Loffler, Kelly, additional, Woodman, Richard, additional, Adams, Robert, additional, Labarca, Gonzalo, additional, Dreyse, Jorge, additional, Eulenburg, Christine, additional, Thunström, Erik, additional, Glantz, Helena, additional, Peker, Yüksel, additional, Anderson, Craig, additional, McEvoy, Doug, additional, and Barbé, Ferran, additional

Published
2023
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12. A blood-based microRNA signature for the early prediction of the respiratory sequelae in critical COVID-19

Author

Molinero García, Marta, primary, Benítez, Ivan D, additional, Perez-Pons, Manel, additional, García-Mateo, Nadia, additional, Ortega, Alicia, additional, Postigo, Tamara, additional, García-Hidalgo, María C, additional, Belmonte, Thalía, additional, Rodríguez-Muñoz, Carlos, additional, González, Jessica, additional, Torres, Gerard, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Estella, Ángel, additional, Tamayo Lomas, Luis, additional, Martínez De La Gándara, Amalia, additional, Socias, Lorenzo, additional, Peñasco, Yhivian, additional, De La Torre, Maria Del Carmen, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Martínez Varela, Ignacio, additional, Martín Delgado, María Cruz, additional, Vidal-Cortés, Pablo, additional, López Messa, Juan, additional, Pérez-García, Felipe, additional, Caballero, Jesús, additional, Añón, Jose M, additional, Loza-Vázquez, Ana, additional, Carbonell, Nieves, additional, Marín-Corral, Judith, additional, Jorge García, Ruth Noemí, additional, Barberà, Carme, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer Roca, Ricardo, additional, García-Gasulla, Darío, additional, Lorente-Balanza, Jose Ángel, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Óscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F, additional, Torres, Antoni, additional, and Barbe Illa, Ferran-Eduard, additional

Published
2023
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13. A plasma microRNA panel strengthens the early prediction of ICU mortality: A multicenter COVID-19 study

Author

Perez-Pons, Manel, primary, Benítez, Ivan D, additional, Molinero, Marta, additional, García-Mateo, Nadia, additional, Ortega, Alicia, additional, Postigo, Tamara, additional, García-Hidalgo, María C., additional, Belmonte, Thalía, additional, Rodríguez-Muñoz, Carlos, additional, González, Jessica, additional, Torres, Gerard, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Estella, Ángel, additional, Tamayo Lomas, Luis, additional, Martínez De La Gándara, Amalia, additional, Socias, Lorenzo, additional, Peñasco, Yhivian, additional, De La Torre, Maria Del Carmen, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Martínez Varela, Ignacio, additional, Martín Delgado, María Cruz, additional, Vidal-Cortés, Pablo, additional, López Messa, Juan, additional, Pérez-García, Felipe, additional, Caballero, Jesus, additional, Añón, José M., additional, Loza-Vázquez, Ana, additional, Carbonell, Nieves, additional, Marin-Corral, Judith, additional, Jorge García, Ruth Noemí, additional, Barberà, Carmen, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Lorente-Balanza, Jose Ángel, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F., additional, Torres, Antoni, additional, Barbé, Ferran, additional, and De Gonzalo-Calvo, David, additional

Published
2023
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15. Adherence to CPAP treatment is associated with a decrease in the incidence of cardiovascular events: an individual participant data meta-analysis

Author

Sanchez De La Torre, Manuel, primary, Gracia-Lavedan, Esther, additional, Benitez, Ivan D., additional, Sánchez-De-La-Torre, Alicia, additional, Moncusí-Moix, Anna, additional, Torres, Gerard, additional, Loffler, Kelly, additional, Woodman, Richard, additional, Adams, Robert, additional, Labarca, Gonzalo, additional, Dreyse, Jorge, additional, Eulenburg, Christine, additional, Thunström, Erik, additional, Glantz, Helena, additional, Peker, Yüksel, additional, Anderson, Craig, additional, Mcevoy, Doug, additional, and Barbé, Ferran, additional

Published
2023
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16. Persistence of lung dysfunction in post-acute COVID-19: a microRNA approach

Author

García-Hidalgo, María C, primary, González, Jessica, additional, Perez-Pons, Manel, additional, Benítez, Iván D, additional, Molinero, Marta, additional, Belmonte, Thalía, additional, Rodríguez-Muñoz, Carlos, additional, Torres, Gerard, additional, Moncusí-Moix, Anna, additional, Gort-Paniello, Clara, additional, Caballero, Jesús, additional, Barberà, Carme, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Lorente-Balanza, José Ángel, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Bermejo-Martín, Jesús F, additional, Torres, Antoni, additional, Barbé, Ferrán, additional, and De Gonzalo-Calvo, David, additional

Published
2023
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17. A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Author

de Gonzalo-Calvo, David, primary, Molinero, Marta, additional, Benítez, Iván D., additional, Perez-Pons, Manel, additional, García-Mateo, Nadia, additional, Ortega, Alicia, additional, Postigo, Tamara, additional, García-Hidalgo, María C., additional, Belmonte, Thalia, additional, Rodríguez-Muñoz, Carlos, additional, González, Jessica, additional, Torres, Gerard, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Estella, Ángel, additional, Tamayo Lomas, Luis, additional, Martínez de la Gándara, Amalia, additional, Socias, Lorenzo, additional, Peñasco, Yhivian, additional, de la Torre, Maria Del Carmen, additional, Bustamante-Munguira, Elena, additional, Gallego Curto, Elena, additional, Martínez Varela, Ignacio, additional, Martin Delgado, María Cruz, additional, Vidal-Cortés, Pablo, additional, López Messa, Juan, additional, Pérez-García, Felipe, additional, Caballero, Jesús, additional, Añón, José M., additional, Loza-Vázquez, Ana, additional, Carbonell, Nieves, additional, Marin-Corral, Judith, additional, Jorge García, Ruth Noemí, additional, Barberà, Carmen, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Lorente-Balanza, Jose Ángel, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F., additional, Torres, Antoni, additional, and Barbé, Ferran, additional

Published
2023
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18. REVISADO GATEKEEPER’s strategy for the multinational large-scale piloting of an eHealth platform: tutorial on how to identify relevant settings and use cases

Author

Batlle García, Jordi de, Benítez Iglesias, Iván, Moncusí Moix, Anna, Androutsos, Odyseeas, Anglés Barbastro, Rosana, Antonini, Alessio, Arana Arri, Eunate, Cabrera Umpiérrez, María Fernanda, Cea Sánchez, Gloria, Dafoulas, George E., Folkvord, Frans, Fullaondo Zabala, Ane, Giuliani, Francesco, Huang, Hsiao-Ling, Innominato, Pasquale Fabio, Kardas, Przemyslaw, Lou, Vivian W.Q., Manios, Yannis, Matsangidou, María, Mercalli, Franco, Mokhtari, Mounir, Pagliara, Silvio, Schellong, Julia, Stieler, Lisa, Votis, Konstantinos, Currás, Paula, Arredondo Waldmeyer, María Teresa, Posada López, Jorge, Guillén Barrionuevo, Sergio, Pecchia, Leandro, Barbé Illa, Ferrán, Torres Cortada, Gerard, Fico, Giuseppe, Batlle García, Jordi de, Benítez Iglesias, Iván, Moncusí Moix, Anna, Androutsos, Odyseeas, Anglés Barbastro, Rosana, Antonini, Alessio, Arana Arri, Eunate, Cabrera Umpiérrez, María Fernanda, Cea Sánchez, Gloria, Dafoulas, George E., Folkvord, Frans, Fullaondo Zabala, Ane, Giuliani, Francesco, Huang, Hsiao-Ling, Innominato, Pasquale Fabio, Kardas, Przemyslaw, Lou, Vivian W.Q., Manios, Yannis, Matsangidou, María, Mercalli, Franco, Mokhtari, Mounir, Pagliara, Silvio, Schellong, Julia, Stieler, Lisa, Votis, Konstantinos, Currás, Paula, Arredondo Waldmeyer, María Teresa, Posada López, Jorge, Guillén Barrionuevo, Sergio, Pecchia, Leandro, Barbé Illa, Ferrán, Torres Cortada, Gerard, and Fico, Giuseppe

Abstract

The World Health Organization’s strategy toward healthy aging fosters person-centered integrated care sustained by eHealth systems. However, there is a need for standardized frameworks or platforms accommodating and interconnecting multiple of these systems while ensuring secure, relevant, fair, trust-based data sharing and use. The H2020 project GATEKEEPER aims to implement and test an open-source, European, standard-based, interoperable, and secure framework serving broad populations of aging citizens with heterogeneous health needs. We aim to describe the rationale for the selection of an optimal group of settings for the multinational large-scale piloting of the GATEKEEPER platform.

Published
2023

19. Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients

Author

González, Jessica, primary, de Batlle, Jordi, additional, Benítez, Iván D., additional, Torres, Gerard, additional, Santisteve, Sally, additional, Targa, Adriano D.S., additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Aguilà, Maria, additional, Seck, Fatty, additional, Ceccato, Adrián, additional, Ferrer, Ricard, additional, Motos, Anna, additional, Riera, Jordi, additional, Fernández, Laia, additional, Menéndez, Rosario, additional, Lorente, José Ángel, additional, Peñuelas, Oscar, additional, Garcia-Gasulla, Dario, additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Abril Palomares, Elena, additional, Aguilera, Luciano, additional, Rodríguez, Alejandro, additional, Boado Varela, Maria Victoria, additional, Beteré, Belén, additional, Pozo-Laderas, Juan Carlos, additional, Solé-Violan, Jordi, additional, Salvador-Adell, Inmaculada, additional, Novo, Mariana Andrea, additional, Barberán, José, additional, Amaya Villar, Rosario, additional, Garnacho-Montero, José, additional, Gómez, José M., additional, Blandino Ortiz, Aaron, additional, Tamayo Lomas, Luis, additional, Úbeda, Alejandro, additional, Catalán-González, Mercedes, additional, Sánchez-Miralles, Angel, additional, Martínez Varela, Ignacio, additional, Jorge García, Ruth Noemí, additional, Franco, Nieves, additional, Gumucio-Sanguino, Víctor D., additional, Bustamante-Munguira, Elena, additional, Valdivia, Luis Jorge, additional, Caballero, Jesús, additional, Gallego, Elena, additional, Rodríguez, Covadonga, additional, Castellanos-Ortega, Álvaro, additional, Trenado, Josep, additional, Marin-Corral, Judith, additional, Albaiceta, Guillermo M., additional, de la Torre, Maria del Carmen, additional, Loza-Vázquez, Ana, additional, Vidal, Pablo, additional, Añón, Jose M., additional, Carbajales Pérez, Cristina, additional, Sagredo, Victor, additional, Carbonell, Nieves, additional, Socias, Lorenzo, additional, Barberà, Carme, additional, Estella, Angel, additional, Diaz, Emili, additional, de Gonzalo-Calvo, David, additional, Torres, Antoni, additional, Barbé, Ferran, additional, Cabello, María Aguilar, additional, Alcaraz-Serrano, Victoria, additional, Aldecoa, Cesar, additional, Alegre, Cynthia, additional, Calderón, Ángela Algaba, additional, Álvarez, Sergio, additional, Ruiz, Antonio Álvarez, additional, Andrea, Ruth, additional, Aparicio, Maria de Alba, additional, Arrieta, Marta, additional, Ayestarán, J. Ignacio, additional, Badia, Joan Ramon, additional, Badía, Mariona, additional, Pravia, Orville Báez, additional, Mariño, Ana Balan, additional, Balsera, Begoña, additional, Barbena, Laura, additional, Barbeta, Enric, additional, Bardi, Tommaso, additional, Segade, Patricia Barral, additional, Barroso, Marta, additional, García, José Ángel Berezo, additional, Bermejo, Jesus, additional, Bigas, Judit, additional, Blancas, Rafael, additional, Cortés, María Luisa Blasco, additional, Saera, María Bodi, additional, Bofill, Neus, additional, Vieiro, María Teresa Bouza, additional, Bueno, Leticia, additional, Bustamante-Munguira, Juan, additional, Martínez, Cecilia del Busto, additional, Hermoso, David Campi, additional, Fernández, Sandra Campos, additional, Cano, Iosune, additional, Canseco, Joan, additional, Fernández, Pablo Cardinal, additional, García, Laura Carrión, additional, Carvalho, Sulamita, additional, Castellà, Manuel, additional, Castellví, Andrea, additional, Castro, Pedro, additional, Centelles-Serrano, María José, additional, Ávila, Ramon Cicuendez, additional, Cillóniz, Catia, additional, Clar, Luisa, additional, Climent, Cristina, additional, Codina, Jordi, additional, Conde, Pamela, additional, Contreras, Sofía, additional, Parra, Raul de Frutos, additional, Sánchez, Raul de Pablo, additional, Mendoza, Diego De, additional, Díaz, Yolanda, additional, Vilas, María Digna Rivas, additional, Moreno, Cristina Dólera, additional, Dot, Irene, additional, Giraudo, Pedro Enríquez, additional, Arijón, Inés Esmorís, additional, Monjo, Teresa Farre, additional, Fernández, Javier, additional, Ferrando, Carlos, additional, Figueras, Albert, additional, Espina, Lorena Forcelledo, additional, Franquesa, Enric, additional, Furro, Àngels, additional, Gabarrus, Albert, additional, Galbán, Cristóbal, additional, García, Felipe, additional, García, Beatriz, additional, Prieto, Emilio García, additional, Redruello, Carlos García, additional, Sagastume, Amaia García, additional, Castillo, Maria Luisa Gascón, additional, Gomà, Gemma, additional, Casal, Vanesa Gómez, additional, Gómez, Silvia, additional, Gonzalez, Carmen Gómez, additional, Gordo, Federico, additional, Gracia, Maria Pilar, additional, Fernández, María José Gutierrez, additional, Herraiz, Alba, additional, Herrán-Monge, Rubén, additional, Ibarz, Mercedes, additional, Iglesias, Silvia, additional, Janer, Maria Teresa, additional, Jiménez, Gabriel, additional, Díaz, Mar Juan, additional, Kiarostami, Karsa, additional, Álvarez, Juan I. Lazo, additional, León, Miguel, additional, López-Gavín, Alexandre, additional, Guerrero, Desiree Macias, additional, Herrera, Nuria Mamolar, additional, Mendiluce, Rafael Mañez, additional, Mantellini, Cecilia L., additional, Naya, Gregorio Marco, additional, Barcos, Iris Marco, additional, Marcos, Pilar, additional, Peis, Enrique Marmol, additional, Cuadrado, Marta Martín, additional, Delgado, María Cruz Martin, additional, Vicente, Paula Martín, additional, Martínez, María, additional, Fernández, Carmen Eulalia Martínez, additional, Juan, Maria Dolores Martínez, additional, Palacios, Basilisa Martínez, additional, Jimenez, Juan Fernando Masa, additional, Masclans, Joan Ramon, additional, Maseda, Emilio, additional, Fernández, Eva María Menor, additional, Banderas, Priscila Metora, additional, Minguez, Olga, additional, Miralbés, Mar, additional, Monclou, Josman, additional, Montejo-González, Juan Carlos, additional, Montserrat, Neus, additional, Aznar, María Mora, additional, Morales, Dulce, additional, Cano, Sara Guadalupe Moreno, additional, Rodríguez, David Mosquera, additional, Muñoz-Bermúdez, Rosana, additional, Nicolás, José María, additional, Bou, Ramon Nogue, additional, Salinas, Rafaela Nogueras, additional, Ocón, Marta, additional, Ortega, Ana, additional, Ossa, Sergio, additional, Pagliarani, Pablo, additional, Parrilla, Francisco, additional, Pedregosa-Díaz, José, additional, Bastida, Leire Pérez, additional, Pérez, Purificación, additional, Pérez-García, Felipe, additional, Planelles, Gloria Pérez, additional, Rubio, Eva Pérez, additional, Laguna, David Pestaña, additional, Prados, Javier, additional, Pujol, Andrés, additional, Coll, Núria Ramon, additional, Sanchez-Giron, Gloria Renedo, additional, Roche-Campo, Ferran, additional, Rodriguez, Laura, additional, Castro, Felipe Rodríguez de, additional, Rodríguez, Silvia, additional, Ruiz, Covadonga Rodríguez, additional, Rubio, Jorge, additional, López, Alberto Rubio, additional, Ruiz-García, Ángela Leonor, additional, Miralles, Miriam Ruiz, additional, Murúa, Pablo Ryan, additional, Paz, Eva Saborido, additional, Degracia, Ana Salazar, additional, Sanchez, Miguel, additional, Sánchez, Ana, additional, Chinesta, Susana Sancho, additional, Santacoloma, Bitor, additional, Sariñena, Maria Teresa, additional, Pensado, Marta Segura, additional, Serra, Lidia, additional, Serra-Fortuny, Mireia, additional, Lázaro, Ainhoa Serrano, additional, Servià, Lluís, additional, Soliva, Laura, additional, Speziale, Carla, additional, Tormos, Adrián, additional, Torres, Mateu, additional, Tranque-Liberal, Celia, additional, Trefler, Sandra, additional, Trujillano, Javier, additional, Vaca, Rafaela, additional, Val, Estela, additional, Ruiz, Luis Valdivia, additional, Vallverdú, Montserrat, additional, Martin-Montalvo, Maria Van der Hofstadt, additional, Adrio, Sabela Vara, additional, Vázquez, Nil, additional, Vengoechea, Javier, additional, Vilà-Vilardel, Clara, additional, Vilanova, Judit, additional, Warrington, Tatiana Villada, additional, Yang, Hua, additional, Yang, Minlan, additional, and Zapatero, Ana, additional

Published
2023
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20. Additional file 7 of Breathing cessation events that compose the apnea–hypopnea index are distinctively associated with the adverse outcomes in Alzheimer’s disease

Author

Targa, Adriano D. S., Benítez, Iván D., Moncusí-Moix, Anna, Dakterzada, Farida, Minguez, Olga, Vaca, Rafaela, Dalmases, Mireia, Sanchez-de-la-Torre, Manuel, Barbé, Ferran, and Piñol-Ripoll, Gerard

Abstract

Additional file 7: Figure S3. PLS regression analysis (cognitive decline). The findings reveal that the pattern of breathing cessation events occurring during NREM sleep that better explains the variability of the sample in terms of cognitive decline is mainly characterized by the presence of hypopneas. PLS, partial least squares.

Published
2023
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21. Additional file 2 of A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Author

de Gonzalo-Calvo, David, Molinero, Marta, Benítez, Iván D., Perez-Pons, Manel, García-Mateo, Nadia, Ortega, Alicia, Postigo, Tamara, García-Hidalgo, María C., Belmonte, Thalia, Rodríguez-Muñoz, Carlos, González, Jessica, Torres, Gerard, Gort-Paniello, Clara, Moncusí-Moix, Anna, Estella, Ángel, Tamayo Lomas, Luis, Martínez de la Gándara, Amalia, Socias, Lorenzo, Peñasco, Yhivian, de la Torre, Maria Del Carmen, Bustamante-Munguira, Elena, Gallego Curto, Elena, Martínez Varela, Ignacio, Martin Delgado, María Cruz, Vidal-Cortés, Pablo, López Messa, Juan, Pérez-García, Felipe, Caballero, Jesús, Añón, José M., Loza-Vázquez, Ana, Carbonell, Nieves, Marin-Corral, Judith, Jorge García, Ruth Noemí, Barberà, Carmen, Ceccato, Adrián, Fernández-Barat, Laia, Ferrer, Ricard, Garcia-Gasulla, Dario, Lorente-Balanza, Jose Ángel, Menéndez, Rosario, Motos, Ana, Peñuelas, Oscar, Riera, Jordi, Bermejo-Martin, Jesús F., Torres, Antoni, and Barbé, Ferran

Abstract

Supplementary Material 2

Published
2023
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22. Additional file 5 of Breathing cessation events that compose the apnea–hypopnea index are distinctively associated with the adverse outcomes in Alzheimer’s disease

Author

Targa, Adriano D. S., Benítez, Iván D., Moncusí-Moix, Anna, Dakterzada, Farida, Minguez, Olga, Vaca, Rafaela, Dalmases, Mireia, Sanchez-de-la-Torre, Manuel, Barbé, Ferran, and Piñol-Ripoll, Gerard

Abstract

Additional file 5: Figure S1. PLS regression analysis (sleep structure). The findings reveal that the most relevant pattern in relation to the breathing cessation events and sleep structure is mainly characterized by the presence of obstructive apneas and an increased number of arousals. PLS, partial least squares; SWS, slow wave sleep.

Published
2023
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23. Additional file 1 of A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study

Author

de Gonzalo-Calvo, David, Molinero, Marta, Benítez, Iván D., Perez-Pons, Manel, García-Mateo, Nadia, Ortega, Alicia, Postigo, Tamara, García-Hidalgo, María C., Belmonte, Thalia, Rodríguez-Muñoz, Carlos, González, Jessica, Torres, Gerard, Gort-Paniello, Clara, Moncusí-Moix, Anna, Estella, Ángel, Tamayo Lomas, Luis, Martínez de la Gándara, Amalia, Socias, Lorenzo, Peñasco, Yhivian, de la Torre, Maria Del Carmen, Bustamante-Munguira, Elena, Gallego Curto, Elena, Martínez Varela, Ignacio, Martin Delgado, María Cruz, Vidal-Cortés, Pablo, López Messa, Juan, Pérez-García, Felipe, Caballero, Jesús, Añón, José M., Loza-Vázquez, Ana, Carbonell, Nieves, Marin-Corral, Judith, Jorge García, Ruth Noemí, Barberà, Carmen, Ceccato, Adrián, Fernández-Barat, Laia, Ferrer, Ricard, Garcia-Gasulla, Dario, Lorente-Balanza, Jose Ángel, Menéndez, Rosario, Motos, Ana, Peñuelas, Oscar, Riera, Jordi, Bermejo-Martin, Jesús F., Torres, Antoni, and Barbé, Ferran

Abstract

Supplementary Material 1

Published
2023
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24. Additional file 6 of Breathing cessation events that compose the apnea–hypopnea index are distinctively associated with the adverse outcomes in Alzheimer’s disease

Author

Targa, Adriano D. S., Benítez, Iván D., Moncusí-Moix, Anna, Dakterzada, Farida, Minguez, Olga, Vaca, Rafaela, Dalmases, Mireia, Sanchez-de-la-Torre, Manuel, Barbé, Ferran, and Piñol-Ripoll, Gerard

Abstract

Additional file 6: Figure S2. PLS regression analysis (pathological markers of Alzheimer’s disease). The findings reveal that the most relevant pattern in relation to the breathing cessation events and pathological markers of AD is characterized by the number of obstructive apneas and hypopneas mostly, without a clear distinctiveness among the Alzheimer’s disease pathological markers. AD, Alzheimer’s disease; Aβ42, amyloid-beta protein; NF-L, neurofilament light; P-tau, phosphorylated-tau; PLS, partial least squares; T-tau, total-tau.

Published
2023
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25. Sleep and circadian health 6 months after critical COVID ‐19 disease

Author

Targa, Adriano D. S., primary, Benítez, Iván D., additional, González, Jessica, additional, Torres, Gerard, additional, Santisteve, Sally, additional, Vaca, Rafaela, additional, Minguez, Olga, additional, Aguilà, Maria, additional, Carmona, Paola, additional, Moncusí‐Moix, Anna, additional, Gort‐Paniello, Clara, additional, Labarca, Gonzalo, additional, Caballero, Jesús, additional, Barberà, Carme, additional, Torres, Antoni, additional, de Gonzalo‐Calvo, David, additional, and Barbé, Ferran, additional

Published
2022
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26. N-antigenemia detection by a rapid lateral flow test predicts 90-day mortality in COVID-19: A prospective cohort study

Author

Almansa, Raquel, primary, Eiros, Jose María, additional, de Gonzalo-Calvo, David, additional, Postigo, Tamara, additional, Ortega, Alicia, additional, Lopez-Izquierdo, Raul, additional, Moncusí-Moix, Anna, additional, Gort-Paniello, Clara, additional, Dominguez-Gil, Marta, additional, de la Fuente, Amanda, additional, González-González, Laura, additional, Luis-García, Tania, additional, García-Mateo, Nadia, additional, Tedim, Ana P., additional, Rodríguez-Jara, Fátima, additional, Jorge, Noelia, additional, González, Jessica, additional, Torres, Gerard, additional, Gutiérrez-Pérez, Oliver Norberto, additional, Villegas, Maria José, additional, Campo, Sonia, additional, Ayllon, Eva, additional, Ruiz Albi, Tomás, additional, de Frutos Arribas, Julio, additional, Arroyo Domingo, Ainhoa, additional, Abadia-Otero, Jesica, additional, Gómez Barquero, Julia, additional, Trapiello, Wysali, additional, Garcia Frade, Luis Javier, additional, Inglada, Luis, additional, del Campo, Felix, additional, Bermejo-Martin, Jesús F., additional, Barbé, Ferran, additional, and Torres, Antoni, additional

Published
2022
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27. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author

Benítez, Iván D., Batlle, Jordi de, Torres, Gerard, González, Jessica, Gonzalo Calvo, David de, Targa, Adriano D.S., Gort Paniello, Clara, Moncusí Moix, Anna, Ceccato, Adrian, Fernández Barat, Laia, Ferrer, Ricard, Garcia Gasulla, Dario, Menéndez, Rosario, Motos, Anna, Peñuelas, Oscar, Riera, Jordi, Bermejo Martin, Jesús F., Peñasco, Yhivian, Ricart, Pilar, Martin Delgado, María Cruz, Aguilera, Luciano, Rodríguez, Alejandro, Boado Varela, Maria Victoria, Suarez Sipmann, Fernando, Pozo Laderas, Juan Carlos, Solé Violan, Jordi, Nieto, Maite, Novo, Mariana Andrea, Barberán, José, Amaya Villar, Rosario, Garnacho Montero, José, García Garmendia, José Luis, Gómez, José M., Lorente, José Ángel, Blandino Ortiz, Aaron, Tamayo Lomas, Luis, López Ramos, Esther, Úbeda, Alejandro, Catalán González, Mercedes, Sánchez Miralles, Angel, Martínez Varela, Ignacio, Jorge García, Ruth Noemí, Franco, Nieves, Gumucio Sanguino, Víctor D., Huerta Garcia, Arturo, Bustamante Munguira, Elena, Valdivia, Luis Jorge, Caballero, Jesús, Gallego, Elena, Martínez de la Gándara, Amalia, Castellanos Ortega, Álvaro, Trenado, Josep, Marin Corral, Judith, Albaiceta, Guillermo M., De La Torre, Maria Del Carmen, Loza-vázquez, Ana, Vidal, Pablo, Lopez Messa, Juan, Añón, José M., Carbajales Pérez, Cristina, Sagredo, Victor, Bofill, Neus, Carbonell, Nieves, Socias, Lorenzo, Barberà, Carme, Estella, Ángel, Valledor Mendez, Manuel, Diaz, Emili, López Lago, Ana, Torres, Antoni, Barbé, Ferran, CIBERESUCICOVID Project (COV20/00110, ISCIII), Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Barcelona Supercomputing Center, and Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic

Subjects
Informàtica::Intel·ligència artificial::Aprenentatge automàtic [Àrees temàtiques de la UPC], Critical Care, Health Policy, COVID-19, Comorbidity, Prognosis, COVID-19 (Malaltia), COVID-19 (Disease), Medicina intensiva, Oncology, Comorbiditat, Ciències de la salut::Medicina::Medicina comunitària i salut pública [Àrees temàtiques de la UPC], mental disorders, Internal Medicine, Critical care medicine
Abstract

Financial support was provided by Instituto de Salud Carlos III (CIBERESUCICOVID, COV20/00110), co- funded by Fondo Europeo de Desarrollo Regional (FEDER), “Una manera de hacer Europa”, Centro de Investigaci on Biom edica en Red − Enfermedades Res- piratorias (CIBERES) and Donation Program “estar pre- parados”, UNESPA, Madrid, Spain. JdB acknowledges receiving financial support from Instituto de Salud Car- los III (ISCIII; Miguel Servet 2019: CP19/00108), co- funded by the European Social Fund (ESF), “Investing in your future”. DdGC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Miguel Servet 2019: CP20/00041), co-funded by the European Social Fund (ESF), “Investing in your future”. AC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Sara Borrell 2021: CD21/00087)., Benítez ID, de Batlle J, Torres G, González J, de Gonzalo-Calvo D, Targa ADS, Gort-Paniello C, Moncusí-Moix A, Ceccato A, Fernández-Barat L, Ferrer R, Garcia-Gasulla D, Menéndez R, Motos A, Peñuelas O, Riera J, Bermejo-Martin JF, Peñasco Y, Ricart P, Martin Delgado MC, Aguilera L, Rodríguez A, Boado Varela MV, Suarez-Sipmann F, Pozo-Laderas JC, Solé-Violan J, Nieto M, Novo MA, Barberán J, Amaya Villar R, Garnacho-Montero J, García-Garmendia JL, Gómez JM, Lorente JÁ, Blandino Ortiz A, Tamayo Lomas L, López-Ramos E, Úbeda A, Catalán-González M, Sánchez-Miralles A, Martínez Varela I, Jorge García RN, Franco N, Gumucio-Sanguino VD, Huerta Garcia A, Bustamante-Munguira E, Valdivia LJ, Caballero J, Gallego E, Martínez de la Gándara A, Castellanos-Ortega Á, Trenado J, Marin-Corral J, Albaiceta GM, de la Torre MDC, Loza-Vázquez A, Vidal P, Lopez Messa J, Añón JM, Carbajales Pérez C, Sagredo V, Bofill N, Carbonell N, Socias L, Barberà C, Estella A, Valledor Mendez M, Diaz E, López Lago A, Torres A, Barbé F; CIBERESUCICOVID Project (COV20/00110, ISCIII)

Published
2022

28. Proteomic profiling of lung diffusion impairment in the recovery stage of SARS‐CoV‐2–induced ARDS

Author

García Hidalgo, María Coronada, González, Jessica, Benítez, Iván, Carmona, Paola, Santisteve, Sally, Moncusí Moix, Anna, Gort Paniello, Clara, Rodríguez Jara, Fátima, Molinero, Marta, Perez-Pons, Manel, Torres, Gerard, Caballero, Jesús, Barberà, Carme, Tedim, Ana P., Almansa, Raquel, Ceccato, Adrián, Fernández Barat, Laia, Ferrer, Ricard, Garcia-Gasulla, Dario, Menéndez, Rosario, Motos, Anna, Peñuelas, Oscar, Riera, Jordi, Bermejo Martin, Jesús F., Torres, Antoni, Barbé Illa, Ferran, and de Gonzalo Calvo, David

Subjects
Proteomics, Pulmons--Malalties, Respiratory Distress Syndrome, SARS-CoV-2, COVID-19, Humans, Molecular Medicine, Medicine (miscellaneous), Proteòmica, Lung, COVID-19 (Malaltia)
Abstract

Financial support was provided by the Instituto de Salud Carlos III de Madrid (COV20/00110), co-funded by the European Development Regional Fund (A Way to Achieve Europe programme) and Centro de Investigación Biomedica En Red Enfermedades Respiratorias(CIBERES). CIBERES is an initiative of the Instituto de Salud Carlos III. Suported by: Programa de donaciones “estar preparados” UNESPA (Madrid, Spain); and Fundación Francisco Soria Melguizo (Madrid, Spain).Finançat per La Fundació La Marató de TV3, projecte amb codi 202108-30/-31. COVIDPONENT is funded by Institut Català de la Salut and Gestió de Serveis Sanitaris. APT was funded by the Sara Borrell Research Grant CD018/0123 funded by the Instituto de Salud Carlos III and co-financed by the European Development Regional Fund (A Way to Achieve Europe programme). MCGH is the recipient of a predoctoral fellowship from the “University of Lleida”.DdGC (Miguel Servet 2020: CP20/00041) and MM (PFIS:FI21/00187) have received financial support from the Instituto de Salud Carlos III, cofunded by the European Social Fund (ESF) / “Investing in your future”

Published
2022

29. Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection

Author

Molinero, Marta, primary, Gómez, Silvia, additional, Benítez, Iván D., additional, Vengoechea, J. J., additional, González, Jessica, additional, Polanco, Dinora, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, García-Hidalgo, María C., additional, Perez-Pons, Manel, additional, Belmonte, Thalía, additional, Torres, Gerard, additional, Caballero, Jesús, additional, Barberà, Carme, additional, Ayestarán Rota, Jose Ignacio, additional, Socías Crespí, Lorenzo, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Lorente-Balanza, Jose Ángel, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Torres, Antoni, additional, Barbé, Ferran, additional, and de Gonzalo-Calvo, David, additional

Published
2022
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30. One Year Overview and Follow-Up in a Post-COVID Consultation of Critically Ill Patients

Author

González, Jessica, primary, Zuil, María, additional, Benítez, Iván D., additional, de Gonzalo-Calvo, David, additional, Aguilar, María, additional, Santisteve, Sally, additional, Vaca, Rafaela, additional, Minguez, Olga, additional, Seck, Faty, additional, Torres, Gerard, additional, de Batlle, Jordi, additional, Gómez, Silvia, additional, Barril, Silvia, additional, Moncusí-Moix, Anna, additional, Monge, Aida, additional, Gort-Paniello, Clara, additional, Ferrer, Ricard, additional, Ceccato, Adrián, additional, Fernández, Laia, additional, Motos, Ana, additional, Riera, Jordi, additional, Menéndez, Rosario, additional, Garcia-Gasulla, Darío, additional, Peñuelas, Oscar, additional, Labarca, Gonzalo, additional, Caballero, Jesús, additional, Barberà, Carme, additional, Torres, Antoni, additional, and Barbé, Ferran, additional

Published
2022
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31. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author

Benítez, Iván D., primary, de Batlle, Jordi, additional, Torres, Gerard, additional, González, Jessica, additional, de Gonzalo-Calvo, David, additional, Targa, Adriano D.S., additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Menéndez, Rosario, additional, Motos, Anna, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Bermejo-Martin, Jesús F., additional, Peñasco, Yhivian, additional, Ricart, Pilar, additional, Martin Delgado, María Cruz, additional, Aguilera, Luciano, additional, Rodríguez, Alejandro, additional, Boado Varela, Maria Victoria, additional, Suarez-Sipmann, Fernando, additional, Pozo-Laderas, Juan Carlos, additional, Solé-Violan, Jordi, additional, Nieto, Maite, additional, Novo, Mariana Andrea, additional, Barberán, José, additional, Amaya Villar, Rosario, additional, Garnacho-Montero, José, additional, García-Garmendia, Jose Luis, additional, Gómez, José M., additional, Lorente, José Ángel, additional, Blandino Ortiz, Aaron, additional, Tamayo Lomas, Luis, additional, López-Ramos, Esther, additional, Úbeda, Alejandro, additional, Catalán-González, Mercedes, additional, Sánchez-Miralles, Angel, additional, Martínez Varela, Ignacio, additional, Jorge García, Ruth Noemí, additional, Franco, Nieves, additional, Gumucio-Sanguino, Víctor D., additional, Huerta Garcia, Arturo, additional, Bustamante-Munguira, Elena, additional, Valdivia, Luis Jorge, additional, Caballero, Jesús, additional, Gallego, Elena, additional, Martínez de la Gándara, Amalia, additional, Castellanos-Ortega, Álvaro, additional, Trenado, Josep, additional, Marin-Corral, Judith, additional, Albaiceta, Guillermo M, additional, de la Torre, Maria del Carmen, additional, Loza-Vázquez, Ana, additional, Vidal, Pablo, additional, Lopez Messa, Juan, additional, Añón, Jose M., additional, Carbajales Pérez, Cristina, additional, Sagredo, Victor, additional, Bofill, Neus, additional, Carbonell, Nieves, additional, Socias, Lorenzo, additional, Barberà, Carme, additional, Estella, Angel, additional, Valledor Mendez, Manuel, additional, Diaz, Emili, additional, López Lago, Ana, additional, Torres, Antoni, additional, and Barbé, Ferran, additional

Published
2022
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32. Bronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill Patients

Author

Barcelona Supercomputing Center, Molinero, Marta, Benítez, Iván D., González, Jessica, Gort Paniello, Clara, Moncusí Moix, Anna, Garcia Gasulla, Dario, Barcelona Supercomputing Center, Molinero, Marta, Benítez, Iván D., González, Jessica, Gort Paniello, Clara, Moncusí Moix, Anna, and Garcia Gasulla, Dario

Abstract

Background: The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile of bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients admitted to the ICU to identify prognostic biomarkers of fatal outcomes and to define molecular pathways involved in the disease and adverse events. Methods: Two patient populations were included (n = 89): (i) a study population composed of critically ill COVID-19 and non-COVID-19 patients; (ii) a prospective study cohort composed of COVID-19 survivors and non-survivors among patients assisted by invasive mechanical ventilation (IMV). BAS samples were obtained by bronchoaspiration during the ICU stay. The miRNA profile was analyzed using RT-qPCR. Detailed biomarker and bioinformatics analyses were performed. Results: The deregulation in five miRNA ratios (miR-122-5p/miR-199a-5p, miR-125a-5p/miR-133a-3p, miR-155-5p/miR-486-5p, miR-214-3p/miR-222-3p, and miR-221-3p/miR-27a-3p) was observed when COVID-19 and non-COVID-19 patients were compared. In addition, five miRNA ratios segregated between ICU survivors and nonsurvivors (miR-1-3p/miR-124-3p, miR-125b-5p/miR-34a-5p, miR-126-3p/miR-16-5p, miR-199a-5p/miR-9-5p, and miR-221-3p/miR-491-5p). Through multivariable analysis, we constructed a miRNA ratio-based prediction model for ICU mortality that optimized the best combination of miRNA ratios (miR-125b-5p/miR-34a-5p, miR-199a-5p/miR-9-5p, and miR-221-3p/miR-491-5p). The model (AUC 0.85) and the miR-199a-5p/miR-9-5p ratio (AUC 0.80) showed an optimal discrimination value and outperformed the best clinical predictor for ICU mortality (days from first symptoms to IMV initiation, AUC 0.73). The survival analysis confirmed the usefulness of the miRNA ratio model and the individual ratio to identify patients at high risk of fatal outcomes following IMV initiation. Functional enrichment analyses identified pathological mechanisms implicated in fibrosis, coagul, We want particularly to acknowledge the patients, Biobank IdISBa and CIBERES Pulmonary Biobank Consortium (PT17/0015/0001), a member of the Spanish National Biobanks Network financed by the Carlos III Health Institute, with the participation of the Units of Intensive Care, Clinical Analysis and Pulmonology of Hospital Universitario Son Espases and Hospital Son Llatzer for their collaboration. This work was also supported by IRBLleida Biobank (B.0000682) and Plataforma Biobancos PT17/0015/0027/., Peer Reviewed, "Article signat per 25 autors/es: Marta Molinero, Iván D. Benítez, Jessica González, Clara Gort-Paniello, Anna Moncusí-Moix, Fátima Rodríguez-Jara, María C. García-Hidalgo, Gerard Torres, J. J. Vengoechea, Silvia Gómez, Ramón Cabo, Jesús Caballero, Jesús F. Bermejo-Martin, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Antoni Torres, Ferran Barbé and David de Gonzalo-Calvo* on behalf of the CIBERESUCICOVID Project (COV20/00110 ISCIII)", Postprint (published version)

Published
2022

33. Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study

Author

Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic, Benítez Iglesias, Iván D., Batlle, Jordi de, Torres Cortada, Gerard, González Gutiérrez, Jessica, de Gonzalo Calvo, David, Targa, Adriano D. S., Gort Paniello, Clara, Moncusí Moix, Anna, Ceccato, Adrián, Fernández Barat, Laia, Ferrer Roca, Ricard, Garcia Gasulla, Dario, Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic, Benítez Iglesias, Iván D., Batlle, Jordi de, Torres Cortada, Gerard, González Gutiérrez, Jessica, de Gonzalo Calvo, David, Targa, Adriano D. S., Gort Paniello, Clara, Moncusí Moix, Anna, Ceccato, Adrián, Fernández Barat, Laia, Ferrer Roca, Ricard, and Garcia Gasulla, Dario

Abstract

Background: The clinical heterogeneity of COVID-19 suggests the existence of different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill COVID-19 patients and assess their impact on in-hospital outcomes, response to treatment and sequelae. Methods: Multicenter prospective/retrospective observational study in intensive care units of 55 Spanish hospitals. 5866 PCR-confirmed COVID-19 patients had comorbidities recorded at hospital admission; clinical and biological parameters, in-hospital procedures and complications throughout the stay; and, clinical complications, persistent symptoms and sequelae at 3 and 6 months. Findings: Latent class analysis identified 3 phenotypes using training and test subcohorts: low-morbidity (n=3385; 58%), younger and with few comorbidities; high-morbidity (n=2074; 35%), with high comorbid burden; and renal-morbidity (n=407; 7%), with chronic kidney disease (CKD), high comorbidity burden and the worst oxygenation profile. Renal-morbidity and high-morbidity had more in-hospital complications and higher mortality risk than low-morbidity (adjusted HR (95% CI): 1.57 (1.34-1.84) and 1.16 (1.05-1.28), respectively). Corticosteroids, but not tocilizumab, were associated with lower mortality risk (HR (95% CI) 0.76 (0.63-0.93)), especially in renal-morbidity and high-morbidity. Renal-morbidity and high-morbidity showed the worst lung function throughout the follow-up, with renal-morbidity having the highest risk of infectious complications (6%), emergency visits (29%) or hospital readmissions (14%) at 6 months (p<0.01). Interpretation: Comorbidity-based phenotypes were identified and associated with different expression of in-hospital complications, mortality, treatment response, and sequelae, with CKD playing a major role. This could help clinicians in day-to-day decision making including the management of post-discharge COVID-19 sequelae., Financial support was provided by Instituto de Salud Carlos III (CIBERESUCICOVID, COV20/00110), co-funded by Fondo Europeo de Desarrollo Regional (FEDER), “Una manera de hacer Europa”, Centro de Investigación Biomédica en Red − Enfermedades Respiratorias (CIBERES) and Donation Program “estar preparados”, UNESPA, Madrid, Spain. JdB acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Miguel Servet 2019: CP19/00108), cofunded by the European Social Fund (ESF), “Investing in your future”. DdGC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Miguel Servet 2019: CP20/00041), co-funded by the European Social Fund (ESF), “Investing in your future”. AC acknowledges receiving financial support from Instituto de Salud Carlos III (ISCIII; Sara Borrell 2021: CD21/00087)., Peer Reviewed, Article signat per 71 autors/es: Iván D. Benítez (a,b,1), Jordi de Batlle (a,b,1), Gerard Torres (a,b), Jessica Gonzáalez (a,b), David de Gonzalo-Calvo (a,b), Adriano D.S. Targa (a,b), Clara Gort-Paniello (a,b), Anna Moncusí-Moix (a,b), Adrián Ceccato (b,c), Laia Fernández-Barat (b,d), Ricard Ferrer (b,e), Dario Garcia-Gasulla (f), Rosario Menéndez (b,g), Anna Motos (b,d), Oscar Peñuelas (b,h), Jordi Riera (b,e), Jesús F. Bermejo-Martin (b,i), Yhivian Peñasco (j), Pilar Ricart (k), María Cruz Martin Delgado(l), Luciano Aguilera(m), Alejandro Rodríguez(n), Maria Victoria Boado Varela (o), Fernando Suarez-Sipmann (p), Juan Carlos Pozo-Laderas (q), Jordi Solé-Violan (r), Maite Nieto (s), Mariana Andrea Novo (t), José Barberán (u), Rosario Amaya Villar (v), José Garnacho-Montero (w), Jose Luis García-Garmendia (x), José M. Gómez (y), José Ángel Lorente (b,h), Aaron Blandino Ortiz (z), Luis Tamayo Lomas (aa), Esther López-Ramos (ab), Alejandro Úbeda (ac), Mercedes Catalán-González (ad), Angel Sánchez-Miralles (ae), Ignacio Martínez Varela (af), Ruth Noemí Jorge García (ag), Nieves Franco (ah), Víctor D. Gumucio-Sanguino (ai), Arturo Huerta Garcia (aj), Elena Bustamante-Munguira (ak), Luis Jorge Valdivia (al), Jesús Caballero (am), Elena Gallego (an), Amalia Martínez de la Gándara (ao), Álvaro Castellanos-Ortega (ap), Josep Trenado (aq), Judith Marin-Corral (ar), Guillermo M Albaiceta (b,as), Maria del Carmen de la Torre (at), Ana Loza-Vázquez (au), Pablo Vidal (av), Juan Lopez Messa (aw), Jose M. Añon (b,ax), Cristina Carbajales Pérez (ay), Victor Sagredo (az), Neus Bofill (ba), Nieves Carbonell (bb), Lorenzo Socias(bc), Carme Barberá (bd), Angel Estella (be), Manuel Valledor Mendez (bf), Emili Diaz (bg), Ana López Lago (bh), Antoni Torres (b,d) and Ferran Barbé (a,b*), on behalf of the CIBERESUCICOVID Project (COV20/00110, ISCIII)2 // (a) Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain; (b), Postprint (published version)

Published
2022

34. Impact of time to intubation on mortality and pulmonary sequelae in critically ill patients with COVID-19: a prospective cohort study

Author

Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic, González Gutiérrez, Jessica, Benítez Iglesias, Iván D., de Gonzalo Calvo, David, Torres Cortada, Gerard, Batlle, Jordi de, Gómez Falguera, Silvia, Moncusí Moix, Anna, Carmona, Paola, Santisteve, Sallya, Gort Paniello, Clara, Ferrer Roca, Ricard, Garcia Gasulla, Dario, Torres, Antoni, Barbé, Ferran, Monge Esqué, Aida, Zuil Moreno, María, Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Barcelona Supercomputing Center, Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic, González Gutiérrez, Jessica, Benítez Iglesias, Iván D., de Gonzalo Calvo, David, Torres Cortada, Gerard, Batlle, Jordi de, Gómez Falguera, Silvia, Moncusí Moix, Anna, Carmona, Paola, Santisteve, Sallya, Gort Paniello, Clara, Ferrer Roca, Ricard, Garcia Gasulla, Dario, Torres, Antoni, Barbé, Ferran, Monge Esqué, Aida, and Zuil Moreno, María

Abstract

We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae. Materials and methods: Prospective cohort of critical COVID-19 patients on IMV. Patients were classified as early intubation if they were intubated within the first 48 h from the first respiratory support or delayed intubation if they were intubated later. Surviving patients were evaluated after hospital discharge. Results: We included 205 patients (140 with early IMV and 65 with delayed IMV). The median [p25;p75] age was 63 [56.0; 70.0] years, and 74.1% were male. The survival analysis showed a significant increase in the risk of mortality in the delayed group with an adjusted hazard ratio (HR) of 2.45 (95% CI 1.29–4.65). The continuous predictor time to IMV showed a nonlinear association with the risk of in-hospital mortality. A multivariate mortality model showed that delay of IMV was a factor associated with mortality (HR of 2.40; 95% CI 1.42–4.1). During follow-up, patients in the delayed group showed a worse DLCO (mean difference of -¿10.77 (95% CI -¿18.40 to -¿3.15), with a greater number of affected lobes (+¿1.51 [95% CI 0.89–2.13]) and a greater TSS (+¿4.35 [95% CI 2.41–6.27]) in the chest CT scan. Conclusions: Among critically ill patients with COVID-19 who required IMV, the delay in intubation from the first respiratory support was associated with an increase in hospital mortality and worse pulmonary sequelae during follow-up., Postprint (published version)

Published
2022

35. Three to Six Months Evolution of Pulmonary Function and Radiological Features in Critical COVID-19 Patients: A Prospective Cohort

Author

Cabo-Gambin, Ramón, primary, Benítez, Iván D., additional, Carmona, Paola, additional, Santiesteve, Sally, additional, Mínguez, Olga, additional, Vaca, Rafaela, additional, Moncusí-Moix, Anna, additional, Gort-Paniello, Clara, additional, García-Hidalgo, María C., additional, de Gonzalo-Calvo, David, additional, de Batlle, Jordi, additional, Torres, Gerard, additional, Torres, Antoni, additional, Barbé, Ferran, additional, and González, Jessica, additional

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2022
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36. Sleep and Circadian Health of Critical COVID-19 Survivors 3 Months After Hospital Discharge

Author

Benítez, Iván D., primary, Moncusí-Moix, Anna, additional, Vaca, Rafaela, additional, Gort-Paniello, Clara, additional, Minguez, Olga, additional, Santisteve, Sally, additional, Carmona, Paola, additional, Torres, Gerard, additional, Fagotti, Juliane, additional, Labarca, Gonzalo, additional, Torres, Antoni, additional, González, Jessica, additional, de Gonzalo-Calvo, David, additional, Barbé, Ferran, additional, and Targa, Adriano D. S., additional

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2022
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37. Bronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill Patients

Author

Molinero, Marta, primary, Benítez, Iván D., additional, González, Jessica, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Rodríguez-Jara, Fátima, additional, García-Hidalgo, María C., additional, Torres, Gerard, additional, Vengoechea, J. J., additional, Gómez, Silvia, additional, Cabo, Ramón, additional, Caballero, Jesús, additional, Bermejo-Martin, Jesús F., additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Torres, Antoni, additional, Barbé, Ferran, additional, and de Gonzalo-Calvo, David, additional

Published
2022
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38. Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS

Author

García-Hidalgo, María C., González, Jessica, Benítez, Iván D., Carmona, Paola, Santisteve, Sally, Pérez-Pons, Manel, Moncusí-Moix, Anna, Gort-Paniello, Clara, Rodríguez-Jara, Fátima, Molinero, Marta, Belmonte, Thalia, Torres, Gerard, Labarca, Gonzalo, Nova-Lamperti, Estefania, Caballero, Jesús, Bermejo-Martin, Jesús F., Ceccato, Adrián, Fernández-Barat, Laia, Ferrer, Ricard, Garcia-Gasulla, Dario, Menéndez, Rosario, Motos, Ana, Peñuelas, Oscar, Riera, Jordi, Torres, Antoni, Barbé, Ferran, de Gonzalo-Calvo, David, and Barcelona Supercomputing Center

Subjects
Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Respiratory Distress Syndrome, Acute respiratory distress syndrome, SARS-CoV-2, Epidemiology, Immunology, Total severity score, COVID-19, MicroRNA, General Medicine, Microbiology, COVID-19 (Malaltia), Lung function, Sequelae, Infectious Diseases, COVID-19 (Disease), Statistical analysis, Virology, Drug Discovery, Humans, Parasitology, Circulating MicroRNA, Survivors, Lung
Abstract

There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS. The study included patients who developed ARDS secondary to SARS-CoV-2 infection (n=167) and a group of infected patients who did not develop ARDS (n=33). Patients were evaluated 3 months after hospital discharge. The follow-up included a complete pulmonary evaluation and chest computed tomography. Plasma miRNA profiling was performed using RT-qPCR. Random forest was used to construct miRNA signatures associated with lung diffusing capacity for carbon monoxide (DLCO) and total severity score (TSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were conducted. DLCO

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2022
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39. Plasma profiling reveals a blood-based metabolic fingerprint of obstructive sleep apnea

Author

Pinilla, Lucía, primary, Benítez, Iván D., additional, Santamaria-Martos, Fernando, additional, Targa, Adriano, additional, Moncusí-Moix, Anna, additional, Dalmases, Mireia, additional, Mínguez, Olga, additional, Aguilà, Maria, additional, Jové, Mariona, additional, Sol, Joaquim, additional, Pamplona, Reinald, additional, Barbé, Ferran, additional, and Sánchez-de-la-Torre, Manuel, additional

Published
2022
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40. Pulmonary function and radiologic features in survivors of critical COVID-19: a 3-month prospective cohort

Author

González Gutiérrez, Jessica, Benítez Iglesias, Iván D., Carmona Arias, Paola, Santisteve, Sallya, Monge Esqué, Aida, Moncusí Moix, Anna, Gort Paniello, Clara, Pinilla Latorre, Lucía, Carratalá García, Amara, Zuil Moreno, María, Ferrer Roca, Ricard, Ceccato, Adrián, Fernández Barat, Laia, Motos Galera, Ana, Riera del Brío, Jordi, Menéndez Villanueva, Rosario, Garcia Gasulla, Dario|||0000-0001-6732-5641, Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Barcelona Supercomputing Center, and Universitat Politècnica de Catalunya. KEMLG - Grup d'Enginyeria del Coneixement i Aprenentatge Automàtic

Subjects
Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], CT abnormalities, SARS, Medicine -- Data processing, Lungs -- Diseases, Ciències de la salut::Medicina [Àrees temàtiques de la UPC], SARS-CoV-2, COVID-19, Pulmons -- Malalties, COVID-19 (Malaltia), Lung function, Malalties -- Complicacions, Sequelae, COVID-19 (Disease), Medical statistics, ICU, Diseases -- Complications, Estadística mèdica, Medicina -- Informàtica
Abstract

© 2021 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ BACKGROUND: More than 20% of hospitalized patients with COVID-19 demonstrate ARDS requiring ICU admission. The long-term respiratory sequelae in such patients remain unclear. RESEARCH QUESTION: What are the major long-term pulmonary sequelae in critical patients who survive COVID-19? STUDY DESIGN AND METHODS: Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated 3 months after hospitalization discharge. The follow-up comprised symptom and quality of life, anxiety and depression questionnaires, pulmonary function tests, exercise test (6-min walking test [6MWT]), and chest CT imaging. RESULTS: One hundred twenty-five patients admitted to the ICU with ARDS secondary to COVID- 19 were recruited between March and June 2020. At the 3-month follow-up, 62 patients were available for pulmonary evaluation. The most frequent symptoms were dyspnea (46.7%) and cough (34.4%). Eighty-two percent of patients showed a lung diffusing capacity of less than 80%. The median distance in the 6MWT was 400 m (interquartile range, 362-440 m). CT scans showed abnormal results in 70.2% of patients, demonstrating reticular lesions in 49.1% and fibrotic patterns in 21.1%. Patients with more severe alterations on chest CT scan showed worse pulmonary function and presented more degrees of desaturation in the 6MWT. Factors associated with the severity of lung damage on chest CT scan were age and length of invasive mechanical ventilation during the ICU stay. INTERPRETATION: Three months after hospital discharge, pulmonary structural abnormalities and functional impairment are highly prevalent in patients with ARDS secondary to COVID- 19 who required an ICU stay. Pulmonary evaluation should be considered for all critical COVID-19 survivors 3 months after discharge. This study was supported in part by the Instituto de Salud Carlos III [Grant CIBERESUCICOVID, COV20/00110] and was cofunded by European Regional Development Funds, “Una manera de hacer Europa.” D. d. G.-C. has received financial support from the Instituto de Salud Carlos III [Grant Miguel Servet 2020: CP20/00041], co-funded by the European Social Fund “Investing in Your Future.” L. P. acknowledges receiving financial support from the Ministry of Science, Innovation and Universities for the Training of University Lecturers (FPU19 / 03526).

Published
2021

41. Pulmonary Function and Radiological Features in Survivors of Critical Covid-19: A 3-Month Prospective Cohort

Author

González, Jessica, Benítez, Iván D., Carmona, Paola, Santisteve, Sally, Monge, Aida, Moncusí-Moix, Anna, Gort-Paniello, Clara, Pinilla, Lucía, Carratalá, Amara, Zuil, María, Ferrer, Ricard, Ceccato, Adrián, Fernández, Laia, Motos, Ana, Riera, Jordi, Menéndez, Rosario, Garcia-Gasulla, Dario, Peñuelas, Oscar, Bermejo-Martin, Jesús F., Labarca, Gonzalo, Caballero, Jesus, Torres, Gerard, de Gonzalo-Calvo, David, Torres, Antoni, and Barbé, Ferran

Subjects
CT abnormalities, SARS, SARS-CoV-2, COVID-19, lung function, ICU, intensive care unit, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, CT, computed tomography, Sequelae, ARDS, acute respiratory syndrome, SF-12, short form health survey, ICU, Original Research, COVID-19, coronavirus disease 2019
Abstract

Background More than 20% of hospitalized patients with coronavirus disease 2019 (COVID-19) develop acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) admission. The long-term respiratory sequelae in ICU survivors remain unclear. Research question what are the major long-term pulmonary sequelae in critical COVID-19 survivors? Study Design and Methods Consecutive patients with COVID-19 requiring ICU admission were recruited and evaluated 3 months after hospitalization discharge. The follow-up comprised symptom and quality of life, anxiety and depression questionnaires, pulmonary function tests, exercise test (6-minute walking test (6MWT)) and chest computed tomography (CT). Results 125 ICU patients with ARDS secondary to COVID-19 were recruited between March and June 2020. At the 3-month follow-up, 62 patients were available for pulmonary evaluation. The most frequent symptoms were dyspnea (46.7%), and cough (34.4%). Eighty-two percent of patients showed a lung diffusing capacity of less than 80%. The median (IQR) distance in the 6MWT was 400 (362;440) meters. CT scans were abnormal in 70.2% of patients, showing reticular lesions in 49.1% and fibrotic patterns in 21.1%. Patients with more severe alterations on chest CT had worse pulmonary function and presented more degrees of desaturation in the 6MWT. Factors associated with the severity of lung damage on chest CT were age and length of invasive mechanical ventilation during the ICU stay. Interpretation Pulmonary structural abnormalities and functional impairment are highly prevalent in surviving ICU patients with ARDS secondary to COVID-19 3 months after hospital discharge. Pulmonary evaluation should be considered for all critical COVID-19 survivors 3 months post discharge.

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2021

42. Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort

Author

Zuil, María, primary, Benítez, Iván D., additional, Cabo-Gambín, Ramón, additional, Manzano Senra, Carlos, additional, Moncusí-Moix, Anna, additional, Gort-Paniello, Clara, additional, de Gonzalo-Calvo, David, additional, Molinero, Marta, additional, Vengoechea Aragoncillo, Jose Javier, additional, Comella, Thais, additional, de Batlle, Jordi, additional, Torres, Gerard, additional, Torres, Antoni, additional, Barbé, Ferrán, additional, and González, Jessica, additional

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2021
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43. Management and Treatment of Patients With Obstructive Sleep Apnea Using an Intelligent Monitoring System Based on Machine Learning Aiming to Improve Continuous Positive Airway Pressure Treatment Compliance: Randomized Controlled Trial

Author

Turino, Cecilia, primary, Benítez, Ivan D, additional, Rafael-Palou, Xavier, additional, Mayoral, Ana, additional, Lopera, Alejandro, additional, Pascual, Lydia, additional, Vaca, Rafaela, additional, Cortijo, Anunciación, additional, Moncusí-Moix, Anna, additional, Dalmases, Mireia, additional, Vargiu, Eloisa, additional, Blanco, Jordi, additional, Barbé, Ferran, additional, and de Batlle, Jordi, additional

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2021
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44. Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients

Author

de GONZALO-CALVO, DAVID, primary, BENÍTEZ, IVÁN D., additional, PINILLA, LUCÍA, additional, CARRATALÁ, AMARA, additional, MONCUSÍ-MOIX, ANNA, additional, GORT-PANIELLO, CLARA, additional, MOLINERO, MARTA, additional, GONZÁLEZ, JESSICA, additional, TORRES, GERARD, additional, BERNAL, MARÍA, additional, PICO, SILVIA, additional, ALMANSA, RAQUEL, additional, JORGE, NOELIA, additional, ORTEGA, ALICIA, additional, BUSTAMANTE-MUNGUIRA, ELENA, additional, GÓMEZ, JOSÉ MANUEL, additional, GONZÁLEZ-RIVERA, MILAGROS, additional, MICHELOUD, DARIELA, additional, RYAN, PABLO, additional, MARTINEZ, AMALIA, additional, TAMAYO, LUIS, additional, ALDECOA, CÉSAR, additional, FERRER, RICARD, additional, CECCATO, ADRIÁN, additional, FERNÁNDEZ-BARAT, LAIA, additional, MOTOS, ANA, additional, RIERA, JORDI, additional, MENÉNDEZ, ROSARIO, additional, GARCIA-GASULLA, DARIO, additional, PEÑUELAS, OSCAR, additional, TORRES, ANTONI, additional, BERMEJO-MARTIN, JESÚS F., additional, and BARBÉ, FERRAN, additional

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2021
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45. Potential translation of plasma microRNA signatures in the risk stratification of COVID-19 patients admitted to the ICU

Author

Benítez, Iván, primary, Carratalá, Amara, additional, Moncusí-Moix, Anna, additional, Gort-Paniello, Clara, additional, Pinilla, Lucía, additional, Molinero, Marta, additional, González, Jessica, additional, Torres, Gerard, additional, Bernal, María, additional, Pico, Silvia, additional, Almansa, Raquel, additional, Jorge, Noelia, additional, Ortega, Alicia, additional, Bustamante-Munguira, Elena, additional, Gómez, Jose Manuel, additional, González-Rivera, Milagros, additional, Micheloud, Dariela, additional, Ryan, Pablo, additional, Martínez, Amalia, additional, Tamayo, Luis, additional, Aldecoa, César, additional, Ferrer, Ricard, additional, Ceccato, Adrián, additional, Fernández, Laia, additional, Motos, Ana, additional, Riera, Jordi, additional, Menéndez, Rosario, additional, Garcia-Gasulla, Dario, additional, Peñuelas, Óscar, additional, Torres, Antoni, additional, Bermejo-Martin, Jesús F, additional, Barbé, Ferran, additional, and de Gonzalo Calvo, David, additional

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2021
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46. Impact of pulmonary rehabilitation on sequelae produced in critically ill patients by COVID-19

Author

ESQUE, AIDA MONGE, primary, Arias, Paola Carmona, additional, Lostes, Sally Santisteve, additional, Moncusí Moix, Anna, additional, De Gonzalo Calvo, David, additional, Paniello, Clara Gort, additional, Cortada, Gerard Torres, additional, Lavedan, Esther Gracia, additional, Barbé Illa, Ferran, additional, and González Gutiérrez, Jessica, additional

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2021
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47. Late Breaking Abstract - MicroRNA profiling informs on the pulmonary sequelae of COVID-19-induced ARDS

Author

García Hidalgo, María Coronada, primary, Benítez, Iván D., additional, Pérez-Pons, Manel, additional, González, Jessica, additional, Carmona, Paola, additional, Santisteve, Sally, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Rodríguez-Jara, Fátima, additional, Molinero, Marta, additional, Torres, Gerard, additional, Bermejo-Martín, Jesús F., additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, García-Casulla, Dario, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Óscar, additional, Riera, Jordi, additional, Torres, Antoni, additional, Barbé, Ferrán, additional, and De Gonzalo-Calvo, David, additional

Published
2021
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48. Late Breaking Abstract - MicroRNA signatures in critically ill COVID-19 patients: a bronchial aspirate study

Author

Molinero García, Marta, primary, Benítez, Iván D., additional, González, Jessica, additional, Gort-Paniello, Clara, additional, Moncusí-Moix, Anna, additional, Rodríguez-Jara, Fátima, additional, García-Hidalgo, María C., additional, Torres, Gerard, additional, Vengoechea, Jose J, additional, Gómez, Silvia, additional, Cabo, Ramón, additional, Caballero, Jesús, additional, Bermejo-Martin, Jesús F., additional, Ceccato, Adrián, additional, Fernández-Barat, Laia, additional, Ferrer, Ricard, additional, Garcia-Gasulla, Dario, additional, Menéndez, Rosario, additional, Motos, Ana, additional, Peñuelas, Oscar, additional, Riera, Jordi, additional, Torres, Antoni, additional, Barbé, Ferran, additional, and De Gonzalo-Calvo, David, additional

Published
2021
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49. Reduced Levels of miR-342-5p in Plasma Are Associated With Worse Cognitive Evolution in Patients With Mild Alzheimer’s Disease

Author

Dakterzada, Farida, primary, David Benítez, Iván, additional, Targa, Adriano, additional, Lladó, Albert, additional, Torres, Gerard, additional, Romero, Leila, additional, de Gonzalo-Calvo, David, additional, Moncusí-Moix, Anna, additional, Tort-Merino, Adria, additional, Huerto, Raquel, additional, Sánchez-de-la-Torre, Manuel, additional, Barbé, Ferran, additional, and Piñol-Ripoll, Gerard, additional

Published
2021
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50. Clinical Consequences of COVID-19 Lockdown in Patients With COPD

Author

González, Jessica, primary, Moncusí-Moix, Anna, additional, Benitez, Ivan D., additional, Santisteve, Sally, additional, Monge, Aida, additional, Fontiveros, Maria Angeles, additional, Carmona, Paola, additional, Torres, Gerard, additional, Barbé, Ferran, additional, and de Batlle, Jordi, additional

Published
2021
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