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Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS
- Source :
- UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC)
- Publication Year :
- 2022
- Publisher :
- Taylor & Francis, 2022.
-
Abstract
- There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS. The study included patients who developed ARDS secondary to SARS-CoV-2 infection (n=167) and a group of infected patients who did not develop ARDS (n=33). Patients were evaluated 3 months after hospital discharge. The follow-up included a complete pulmonary evaluation and chest computed tomography. Plasma miRNA profiling was performed using RT-qPCR. Random forest was used to construct miRNA signatures associated with lung diffusing capacity for carbon monoxide (DLCO) and total severity score (TSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were conducted. DLCO
- Subjects :
- Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]
Respiratory Distress Syndrome
Acute respiratory distress syndrome
SARS-CoV-2
Epidemiology
Immunology
Total severity score
COVID-19
MicroRNA
General Medicine
Microbiology
COVID-19 (Malaltia)
Lung function
Sequelae
Infectious Diseases
COVID-19 (Disease)
Statistical analysis
Virology
Drug Discovery
Humans
Parasitology
Circulating MicroRNA
Survivors
Lung
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC)
- Accession number :
- edsair.doi.dedup.....2bd68869537a377997200e1736e7cfef
- Full Text :
- https://doi.org/10.6084/m9.figshare.19826141