1. Delayed hypersensitivity reaction to allopurinol: A case report
- Author
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Mohammad Che Man, Shahidah Che Alhadi, Wan Fatimah Suriyani Wan Mahmud, Salman Amiruddin, Mohd Zhafri Mohd Razib, and Rasimah Ismail
- Subjects
delayed hypersensitivity ,allopurinol ,rashes ,xanthine oxidase inhibitor ,Medicine - Abstract
Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management.
- Published
- 2023
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