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Delayed hypersensitivity reaction to allopurinol: A case report
- Source :
- Malaysian Family Physician, Vol 18, p 11 (2023)
- Publication Year :
- 2023
- Publisher :
- Academy of Family Physicians of Malaysia, 2023.
-
Abstract
- Allopurinol is the well-known first-line treatment option for symptomatic hyperuricaemia and gout. It is cost-effective particularly for the management of chronic gout. The common early side effects of allopurinol are skin rashes, diarrhoea and nausea. Meanwhile, a dangerous concerning complication is Stevens–Johnson syndrome, which can cause severe morbidity and mortality. Delayed hypersensitivity to allopurinol is rare but should be one of the differential diagnoses if a patient with underlying gout on chronic allopurinol treatment presents with skin rashes. The present case highlights the importance of a high index of suspicion in at-risk patients with underlying gout along with skin rashes on long-term allopurinol treatment to avoid unnecessary patient management.
- Subjects :
- delayed hypersensitivity
allopurinol
rashes
xanthine oxidase inhibitor
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 1985207X and 19852274
- Volume :
- 18
- Database :
- Directory of Open Access Journals
- Journal :
- Malaysian Family Physician
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.852b3676e0ea458287bb85ba462bc0e4
- Document Type :
- article
- Full Text :
- https://doi.org/10.51866/cr.65