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Your search keyword '"Mitani, Akitoshi"' showing total 16 results
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16 results on '"Mitani, Akitoshi"'

1. Mouse eosinophil‐associated ribonuclease‐2 exacerbates the allergic response.

Author

Nguyen, Linh Manh, Kanda, Akira, Kamioka, Yuji, Tokuhiro, Keizo, Kobayashi, Yoshiki, Yun, Yasutaka, Bui, Dan Van, Chu, Hanh Hong, Le, Nhi Kieu Thi, Suzuki, Kensuke, Mitani, Akitoshi, Shimamura, Akihiro, Fukui, Kenta, Dombrowicz, David, and Iwai, Hiroshi

Subjects
GRANTS in aid (Public finance), HOUSE dust mites, HOMOLOGY (Biology), TECHNICAL drawing, HEMATOXYLIN & eosin staining, PULMONARY eosinophilia
Abstract

The article discusses the role of mouse eosinophil-associated ribonuclease-2 (mEAR2) in allergic asthma. The study found that mEAR2 is not necessary for the development and function of eosinophils at rest, but it plays a crucial role in allergic airway inflammation (AAI). The absence of mEAR2 in mice resulted in decreased lung inflammation, reduced eosinophil recruitment, and diminished airway hyperresponsiveness. Additionally, mEAR2 was found to enhance the production of type 2 cytokines and IgE, contributing to the allergic response. The findings suggest that mEAR2 could serve as a potential biomarker for asthma management and a therapeutic target. [Extracted from the article]

Published
2024
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2. CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively

Author

Bui, Dan Van, primary, Nguyen, Linh Manh, additional, Kanda, Akira, additional, Chu, Hanh Hong, additional, Thi Le, Nhi Kieu, additional, Yun, Yasutaka, additional, Kobayashi, Yoshiki, additional, Suzuki, Kensuke, additional, Mitani, Akitoshi, additional, Shimamura, Akihiro, additional, Fukui, Kenta, additional, Sawada, Shunsuke, additional, Dombrowicz, David, additional, and Iwai, Hiroshi, additional

Published
2024
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5. Inoculation of lymphocytes from young mice prevents progression of age-related hearing loss in a senescence-associated mouse model

Author

Mitani, Akitoshi, primary, Iwai, Hiroshi, additional, Inaba, Muneo, additional, Van Bui, Dan, additional, Miwa, Toru, additional, Nguyen, Linh Manh, additional, Hanh, Chu Hong, additional, Sakagami, Tomofumi, additional, Suzuki, Kensuke, additional, Kobayashi, Yoshiki, additional, Yun, Yasutaka, additional, Sugita, Yuuki, additional, and Kanda, Akira, additional

Published
2023
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6. The Neutralization of the Eosinophil Peroxidase Antibody Accelerates Eosinophilic Mucin Decomposition.

Author

Kobayashi, Yoshiki, Chu, Hanh Hong, Bui, Dan Van, Yun, Yasutaka, Nguyen, Linh Manh, Mitani, Akitoshi, Suzuki, Kensuke, Asako, Mikiya, Kanda, Akira, and Iwai, Hiroshi

Subjects
MUCINS, IMMUNOGLOBULINS, MONOCLONAL antibodies, EOSINOPHILS, PEROXIDASE, ENZYME-linked immunosorbent assay, ASTHMA
Abstract

Eosinophilic airway inflammation, complicated by bronchial asthma and eosinophilic chronic rhinosinusitis (ECRS), is difficult to treat. The disease may become refractory when eosinophilic mucin associated with eosinophil peroxidase (EPX) and autoantibodies fills in the paranasal sinus and small airway. This study investigated the functional role of an anti-EPX antibody in eosinophilic mucin of ECRS in eosinophilic airway inflammation. Eosinophilic mucin was obtained from patients with ECRS. The effects of the anti-EPX antibody on dsDNA release from eosinophils and eosinophilic mucin decomposition were evaluated. Immunofluorescence or enzyme-linked immunosorbent assays were performed to detect the anti-EPX antibody and its supernatant and serum levels in eosinophilic mucin, respectively. The serum levels of the anti-EPX antibody were positively correlated with sinus computed tomography score and fractionated exhaled nitrogen oxide. Patients with refractory ECRS had higher serum levels of the anti-EPX antibody than those without. However, dupilumab treatment decreased the serum levels of the anti-EPX antibody. Immunoglobulins (Igs) in the immunoprecipitate of mucin supernatants enhanced dsDNA release from eosinophils, whereas the neutralization of Igs against EPX stopped dsDNA release. Furthermore, EPX antibody neutralization accelerated mucin decomposition and restored corticosteroid sensitivity. Taken together, the anti-EPX antibody may be involved in the formulation of eosinophilic mucin and be used as a clinical marker and therapeutic target for intractable eosinophilic airway inflammation. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Efficacy of Combination Therapy with Lenvatinib and Radioactive Iodine in Thyroid Cancer Preclinical Model

Author

Suzuki, Kensuke, primary, Iwai, Hiroshi, additional, Utsunomiya, Keita, additional, Kono, Yumiko, additional, Watabe, Tadashi, additional, Kobayashi, Yoshiki, additional, Bui, Dan Van, additional, Sawada, Shunsuke, additional, Yun, Yasutaka, additional, Mitani, Akitoshi, additional, Fukui, Kenta, additional, Sakai, Haruka, additional, Chu, Hanh Hong, additional, Linh, Nguyen Manh, additional, Tanigawa, Noboru, additional, and Kanda, Akira, additional

Published
2022
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9. CCL4 Functions as a Biomarker of Type 2 Airway Inflammation

Author

Kobayashi, Yoshiki, primary, Chu, Hanh Hong, additional, Kanda, Akira, additional, Yun, Yasutaka, additional, Shimono, Masami, additional, Nguyen, Linh Manh, additional, Mitani, Akitoshi, additional, Suzuki, Kensuke, additional, Asako, Mikiya, additional, and Iwai, Hiroshi, additional

Published
2022
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13. Corrigendum to “The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions” [Allergol Int 70 (2021) 9–18]

Author

Kanda, Akira, primary, Yun, Yasutaka, additional, Van Bui, Dan, additional, Nguyen, Linh Manh, additional, Kobayashi, Yoshiki, additional, Suzuki, Kensuke, additional, Mitani, Akitoshi, additional, Sawada, Shunsuke, additional, Hamada, Satoko, additional, Asako, Mikiya, additional, and Iwai, Hiroshi, additional

Published
2021
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16. Treg and IL-1 receptor type 2-expressing CD4 + T cell-deleted CD4 + T cell fraction prevents the progression of age-related hearing loss in a mouse model.

Author

Iwai H, Inaba M, Van Bui D, Suzuki K, Sakagami T, Yun Y, Mitani A, Kobayashi Y, and Kanda A

Subjects
Animals, CD4-Positive T-Lymphocytes immunology, Disease Models, Animal, Disease Progression, Mice, Receptors, Interleukin-1 Type II immunology, T-Lymphocyte Subsets immunology, T-Lymphocytes, Regulatory immunology, CD4-Positive T-Lymphocytes transplantation, Presbycusis immunology, Presbycusis prevention & control, T-Lymphocyte Subsets transplantation
Abstract

We investigated the association between cellular immunity and age-related hearing loss (ARHL) development using three CD4 + T cell fractions, namely, naturally occurring regulatory T cells (Treg), interleukin 1 receptor type 2-expressing T cells (I1R2), and non-Treg non-I1R2 (nTnI) cells, which comprised Treg and I1R2-deleted CD4 + T cells. Inoculation of the nTnI fraction into a ARHL murine model, not only prevented the development of ARHL and the degeneration of spiral ganglion neurons, but also suppressed serum nitric oxide, a source of oxidative stress. Further investigations on CD4 + T cell fractions could provide novel insights into the prevention of aging, including presbycusis., (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2021
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