Treg and IL-1 receptor type 2-expressing CD4 + T cell-deleted CD4 + T cell fraction prevents the progression of age-related hearing loss in a mouse model.

Authors :: Iwai H
Inaba M
Van Bui D
Suzuki K
Sakagami T
Yun Y
Mitani A
Kobayashi Y
Kanda A
Source :: Journal of neuroimmunology [J Neuroimmunol] 2021 Aug 15; Vol. 357, pp. 577628. Date of Electronic Publication: 2021 Jun 08.
Publication Year :: 2021
Abstract: We investigated the association between cellular immunity and age-related hearing loss (ARHL) development using three CD4 <superscript>+</superscript> T cell fractions, namely, naturally occurring regulatory T cells (Treg), interleukin 1 receptor type 2-expressing T cells (I1R2), and non-Treg non-I1R2 (nTnI) cells, which comprised Treg and I1R2-deleted CD4 <superscript>+</superscript> T cells. Inoculation of the nTnI fraction into a ARHL murine model, not only prevented the development of ARHL and the degeneration of spiral ganglion neurons, but also suppressed serum nitric oxide, a source of oxidative stress. Further investigations on CD4 <superscript>+</superscript> T cell fractions could provide novel insights into the prevention of aging, including presbycusis.<br /> (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)

Subjects :: Animals
CD4-Positive T-Lymphocytes immunology
Disease Models, Animal
Disease Progression
Mice
Receptors, Interleukin-1 Type II immunology
T-Lymphocyte Subsets immunology
T-Lymphocytes, Regulatory immunology
CD4-Positive T-Lymphocytes transplantation
Presbycusis immunology
Presbycusis prevention & control
T-Lymphocyte Subsets transplantation

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