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2. Subcutaneous anti-COVID-19 hyperimmune immunoglobulin for prevention of disease in asymptomatic individuals with SARS-CoV-2 infection: a double-blind, placebo-controlled, randomised clinical trial

Author

Aguilar-Uroz, Adrià, Rosell-García-Ufano, Adrià, Escudero Planas, Adrián, Baelo, Aida, Villahoz Martín, Ainhoa, Moreno López, Alberto, Roldan Ruiz, Alberto, Santana Briongos, Alberto, Tejera Bodas, Alberto, Alonso-Vallés, Alejandro, Fletes-Pérez, Alejandro, Hueso-Mor, Alejandro, Boluda, Alex, Santamaria, Alex, Diestro, Alicia Santos, Revuelta-Álvarez, Almudena, Moreno Moreno, Álvaro, Ortega de Felipe, Ana, Chen-Ye, Ana, Blázquez Valerón, Ana, Rodríguez Pérez, Ana Belén, Tristán Morgalo, Ana Laura, Fernández-Allende, Ana Luisa, Bagán-Trejo, Andrea, Fernández Juan, Andrés, Zalve-Cano, Ángel, Mateo-Martínez, Anna, Galván, Antonio Valero, Egidos-Plaja, Antonio, Jorge, Ariadna, Fraile Torres, Arturo, Pareja Leal, Azahara Maria, Viader Castro, Bárbara, Fernandez Beato, Barbara, Naveira Menchen, Barbara, Martin Poyatos, Beatriz, García-Martínez, Beatriz, Rodrigo Testillano, Belén, Blanco Tejedor, Belen, López Pérez, Blanca, Mencía Hernanz, Blanca, González-Beiras, Camila, Batres, Carlos, Nuñez Garcia, Carmen, Merino-Rodríguez, Carmen, Rodríguez-Gilabert, Carolina, Bonilla Penedo, Celia, Casado Gomez, Christian, Gonzalez Perez, Claudia, Galindo-Tomás, Claudia, Peral Bolaños, Cristina, Blanco-Montes, Cristina, Lupu-Yakovleva, Cristina, Lopez Ruiz, Cristina, Perez Mayoral, Cristina, Fornes, Cristina, Garcia Corrochano, Cristobal, Gallardo Álvarez, Daniel, Navarro Sanz, Daniel, Sanz Barrio, David, Ramet Meseguer, Debora, Vera-Jurado, Edna Margarita, Perez Costa, Eduardo, Bustillos-Sebastian, Eilen Junet, Palomar Casado, Elena, Guerrero, Elena Dorrego, Medina Mateos, Elena, Aragón Gaspar, Elisa Rebeca, Herrero-Vila, Elisabeth, Paez Herrera, Enriqueta, Rojas Powel, Esmeralda, Robres Medialdea, Esther, Vall-Ribalta, Esther, Lopez Perez, Eva, Mihaela Fer, Felicia, Vazquez Ángeles, Fernanda, Tirado Bejarano, Fernando, Prats-Domenech, Ferran, Borràs Martí, Ferran, Ardila-Mejia, Gabriela, Costes, Gèlia, Gómez Arquero, Gema, Flores Mateo, Gemma, Pintos-Morell, Guillem, Mira-Centelles, Helena, Astola Requena, Ignacio, Ortega Martin, Ignacio, Leivas-Gutierrez, Iker, Escribano Valenciano, Irene, Muñoz Gomez, Irene, Ortega, Irina, Montserrat-Lloan, Isabel, Gamboa, Itziar, Rodríguez de Torres de Paul, Jacobo, Cahís, Jordi, Muñoz-Martinez, Jordi, Bermejo, Jorge Iglesias, Cejas López, Joselvis Virginia, Canudas, Josep, García Lucas, Juan Antonio, Martínez-Pino, Juan Carlos, Torres Martínez, Juana, Pujol-Corney, Judit, González Jiménez, Judith, Gurí, Júlia, Labella Martín, Julio, Garcia-Cano, Laia, Perez Plata, Lara Sonsoles, Muñoz Álvaro, Laura, Rodríguez Andrés, Laura, Vega Ruiz, Laura, Cuevas Valiente, Laura, Díaz Rodríguez, Laura, Puigros, Laura, Cristina Piciorang, Lavinia, Escudero, Leticia, Figueroa Caballero, Liliana, Ferrerfàbrega-Costals, Lluna, Costafreda-Hernández, Lucía, De-Paúl, Lucía, González Fernández-Medina, Luis, Moliner Prada, M<ce:sup loc='post">a</ce:sup> Carmen, Berriochoa Martínez de Pisón, M<ce:sup loc='post">a</ce:sup> Cristina, Blanco Blasco, Maria, Gil Jorge, Maria, Cortijo Caballero, María, Ubals, Maria, Gordillo, Maria, Guilloto López, Maria Alicia, Moreno Calvo, Maria Concepción, Gil García, María del Rosario, Dueñas Román, María Inmaculada, Gonzalez Sanchez, Maria Josefa, Nicolás Campoy, María Luisa, González Velayos, Maria Luz, Zori, Mario Mejías, Maqueda, Mario Oliva, Caño de la Cruz, Mario, Palau-Morral, Mariona, Martín-Muñoz, Marta, Cereceda Meca, Marta, Díaz Urbina, Marta, VerónicaPlazas, Martha, Vall-Mayans, Martí, Blasco, Martí, Jane Chu-Sifuentes, Mary, García de Villasladad Peñaranda, Miguel, Hernanz Sotoca, Miguel, Iglesias Gonzalez, Miguel, Labrador-Galván, Miguel Ángel, Rodrigo de Vivar Azcarate, Miguel, Gil-Fibla, Miquel, Formentí-Pallarés, Miquel, Esteve-Tugues, Mireia, Juanes Perez, Miriam, López Rubio, Miriam, Recuero Renales, Mirian, Hijós-Rullo, Mònica, Lleonart-Abadia, Montserrat, Finelli, Nadia, Rojas-Bertier, Naiara, Reyes-Calderón, Nataly, Casado Larrañaga, Nerea, Zurita Castrosin, Nerea Nuria, Álvarez-Nieto, Noélia, Leiva-Mora, Nuria, Tomillo-Martín, Olga, Belghazi, Omar, Buscà, Oriol, Mendoza Cediel, Pablo, Macedo, Pablo, Rodríguez Barroso, Patricia, Ruiz Álvarez, Patricia, López, Patricia Morales, Vara de Rey, Patricia Jimenez, Ginés, Paz Lozano, Bris Rodriguez, Pilar, Martínez-Alamillo, Pilar, Salmerón Martínez, Rafa, Botello Ariza, Raquel, Vaquero Mena, Raquel, González-Alonso, Raquel, Kaczmarczyk, Raul, Barnadas Vintró, Rita, Hontecillas Martínez, Rodrigo, Ribot-Rodríguez, Rosa, Escobar-Sánchez, Rosa, Montes Trinidad, Rosario Paloma, Martínez Quintana, Rubén, Arnay Arrogante, Ruben, Berjon Sanchez, Ruben, Picazo Navarro, Ruben, Bastos, Rubén, Martín Molinero, Samuel, Israel-Benchaya, Samuel Dan, Muñoz-Burguillo, Sandra, Rodríguez-Salvador, Sandra, Avila, Sara, Corral Gayubas, Sara, Nuñez Sánchez, Sergio, Torres Weber, Sofía, Encabo Lopez, Susana, Torices Rasines, Teresa, Sallas, Valentí, Curto-Vicente, Verónica, Gómez Hijosa, Verónica, Daimiel-Pedrote, Verónica, Gozalo, Verónica, Barrios López, Vicente, Castillo Montoya, Virginia Ivette, Espinoza Pérez, Yuri, CristinaBerriochoa Martínez de Pisón, María, Muñoz Castillo, David, Donato, Carlos, García García, Isabel, Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Suñer, Clara, Galvan-Casas, Cristina, Carrera, Caty, Ouchi, Dan, Prat, Núria, Ara, Jordi, Nadal, Nuria, Riel, Ricard, Funollet, Blanca, Ojeda-Ciurana, Carmen, Balague, Lluis Esteve, Salvador-González, Betlem, Arcarons, Anna Forcada, Vidal-Alaball, Josep, Del Cura-González, María Isabel, Barrientos, Ricardo Rodríguez, Ramos-Blanes, Rafel, Bou, Alberto Alum, Mondou, Elsa, Torres, Mireia, Campins, Neus, Sanz, Ana, Tang, Yonggiang, Rodriguez-Arias, Miquel Àngel, Bassat, Quique, Clotet, Bonaventura, and Mitjà, Oriol

Published
2023
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3. Human and entomological determinants of malaria transmission in the Lihir Islands of Papua New Guinea: A cross-sectional study.

Author

Millat-Martínez, Pere, Katusele, Michelle, Kasian, Bernadine, Omera, Elias, Jamea, Esther, Lorry, Lina, Casellas, Aina, Ouchi, Dan, Wali, Chilaka, Raulo, Sylvia, Elizah, Arthur, Kaman, Peter, Dau, Absalom, Sakur, Muker, Kilepak, Lemen, Yabu, Siub, Koata, Nelson, Kave, John, Toa, Michael, and Urakusie, Christopher

Subjects
*RAPID diagnostic tests, *LOGISTIC regression analysis, *COMMUNITY-based programs, *MIXED infections, *MALARIA prevention, *INSECTICIDE-treated mosquito nets
Abstract

Background: The Lihir Islands of Papua New Guinea, located in an area with high burden of malaria and hosting a large mining operation, offer a unique opportunity to study transmission. There, we investigated human and vector factors influencing malaria transmission. Methods: In 2019, a cross-sectional study was conducted on 2,914 individuals assessing malaria prevalence through rapid diagnostic tests (RDT), microscopy, and quantitative PCR (qPCR). A logistic regression analysis identified infection-associated factors. Anopheles species distribution, biting behaviours, and sporozoite carriage were assessed through human landing catches and larval surveys. Results: Overall malaria prevalence (any species) was 3.6% by RDT, 4.5% by microscopy, and 15.0% by qPCR. P. vivax accounted for 37.1% of infections, P. falciparum for 34.6%, P. malariae for 3.0%, P. ovale 0.2%, and mixed infections for 24.5%. Prevalence (qPCR) varied across geographic areas, from 8.5% in the mine-impacted zone (MIZ) to 27.0% in the non-MIZ. Other factors independently associated with infection risk included cohabiting with an infected individual (aOR = 1.94, 95%CI: 1.56–2.42), and residing in traditional housing (aOR = 1.65, 95%CI: 1.21–2.25). Children had double the infection risk compared to adults, and the use of long-lasting insecticidal-treated nets did not decrease risk of infection. An. punctulatus was the major vector in one of the four geographical areas; while An. farauti was predominant in the rest of them, both with an early biting behaviour but with different biting intensities by geographical area. Entomological inoculation rates ranged from 26.9 (95%CI: 12.3–45.2) infective bites per person-year in the MIZ to 441.3 (95%CI: 315.7–572.1) in the non-MIZ. Conclusions: Malaria transmission and infection was lower in the MIZ compared to other areas. Measures focusing on at-risk groups, including vector-control and transmission interruption methods, could be taken into account by the mine and the healthcare authorities to reduce malaria burden outside the MIZ. Author summary: The Lihir Islands of Papua New Guinea host a mining operation on Aniolam, the main island, which implements specific vector control strategies in the mine-impacted zone (MIZ); whereas the remaining areas rely solely on distribution of long-lasting insecticidal-treated nets (LLIN). Our study compared transmission dynamics in the different geographic areas and demonstrated lower malaria incidence, prevalence, Anopheles density and biting intensities in the MIZ. Living outside the MIZ on Aniolam and on Malie Island was associated with a higher risk of infection, with transmission metrics rarely seen outside high burden countries in sub-Saharan Africa. Besides the geographic area, other risk factors for infection included younger age, cohabiting with infected individuals, and living in traditional housing; while the use of LLINs was not associated with a reduction of infection risk. Our results highlight the need for tailored strategies based on local transmission patterns and could be beneficial for ongoing initiatives aimed at malaria control and elimination. In Lihir, there is an opportunity to invest and improve the collaboration between the mine company and public health authorities. Such a public-private partnership could enhance control efforts, including expansion of diagnostics and treatments, the vector control program and community education beyond the MIZ. [ABSTRACT FROM AUTHOR]

Published
2025
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4. High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Author

Ferrer, Susana, Gallardo, Mireia, Ubals, Maria, González-Beiras, Camila, Vall-Mayans, Martí, Suñer, Clara, Laporte-Villar, Clàudia, Nieto, Aroa, Comas-Leon, Xavier, Jiménez, Zahida, Ramírez-Viaplana, Ferran, Delgado-Capel, Maria, Díez Sánchez, Beatriz, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, González García, David, Vivero Larraza, Ainhoa, Carceles Peiró, Victor, Roquer López, Clàudia, Robert, Neus, Palet, Carles, Gudiol, Carlota, Casares Gonzalez, Pablo, Arcos Vila, Gemma, Flores Aguilera, Begoña, Rodríguez-Sevilla, Graciela, Dastis Arias, Macarena, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Tarres García, Silvia, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Línio, Rosa, Fornos, Míriam, Casamitjana, Natàlia, Alonso, Eva, Martínez, Núria, Maglio, Laura Analía, Comellas Fernandez, Laura, Garcia, Nadia, Hernández, Luis, González, Maria Isabel, Bravo, Anna, García, Yolanda, Sauleda Oliveras, Silvia, Vertiz, Tatiana, Benavent, Sergio, Bianco, Andrea Sofia, Verdaguer, Joaquim, Briones Zambrano, Ney Nicanor, Viozquez Meya, Maria, Hernández, Águeda, Casaña Lopez, Cristina, Bordoy, Antoni E., González Soler, Victoria, Giménez, Montserrat, París, Alexa, Marfil, Silvia, Trinité, Benjamin, Grau, Eulàlia, Alemany, Andrea, Millat-Martinez, Pere, Corbacho-Monné, Marc, Malchair, Pierre, Ouchi, Dan, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodríguez Codina, Joana, Amado Simon, Rosa, Videla, Sebastian, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Bonet Papell, Glòria, Puig, Jordi, Otero, Aurema, Ruibal Suarez, Jose Carlos, Zarauza Pellejero, Alvaro, Llopis Roca, Ferran, Rodriguez Cortez, Orlando, Garcia Garcia, Vanesa, Vidal-Alaball, Josep, Millan, Anna, Contreras, Enric, Grifols, Joan-Ramon, Ancochea, Àgueda, Galvan-Femenia, Ivan, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Prat, Núria, Ara, Jordi, Forcada Arcarons, Anna, Farré, Magí, Pradenas, Edwards, Blanco, Julià, Àngel Rodriguez-Arias, Miquel, Fernández Rivas, Gema, Marks, Michael, Bassat, Quique, Blanco, Ignacio, Baro, Bàrbara, Clotet, Bonaventura, and Mitjà, Oriol

Published
2022
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5. Performance characteristics of five antigen-detecting rapid diagnostic test (Ag-RDT) for SARS-CoV-2 asymptomatic infection: a head-to-head benchmark comparison

Author

Baro, Bàrbara, Rodo, Pau, Ouchi, Dan, Bordoy, Antoni E., Saya Amaro, Emilio N., Salsench, Sergi V., Molinos, Sònia, Alemany, Andrea, Ubals, Maria, Corbacho-Monné, Marc, Millat-Martinez, Pere, Marks, Michael, Clotet, Bonaventura, Prat, Nuria, Estrada, Oriol, Vilar, Marc, Ara, Jordi, Vall-Mayans, Martí, G-Beiras, Camila, Bassat, Quique, Blanco, Ignacio, and Mitjà, Oriol

Published
2021
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7. Coverage, determinants of use and repurposing of long-lasting insecticidal nets two years after a mass distribution in Lihir Islands, Papua New Guinea: a cross-sectional study

Author

Millat-Martínez, Pere, Gabong, Rebecca, Balanza, Núria, Luana, Sakaia, Sanz, Sergi, Raulo, Silvia, Elizah, Arthur, Wali, Chilaka, Paivu, Benjamin, Dalmas, Julian, Tabie, Samson, Karl, Stephan, Laman, Moses, Pomat, William, Mitjà, Oriol, Baro, Bàrbara, and Bassat, Quique

Published
2021
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8. HOSPITALIZATIONS DUE TO PROSTHETIC JOINT INFECTION IN SPAIN DURING THE PERIOD 2000 TO 2015

Author

Gómez-Junyent, Joan, primary, Redó, Maria Luisa Sorli, additional, Pelegrín, Ivan, additional, Millat-Martínez, Pere, additional, Pérez-Prieto, Daniel, additional, Alier, Albert, additional, Verdié, Lluis Puig, additional, Poblet, Judith, additional, Pardos, Sonia Luque, additional, Montero, María Milagro, additional, and Horcajada, Juan Pablo, additional

Published
2023
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10. Piperaquine Pharmacokinetic and Pharmacodynamic Profiles in Healthy Volunteers of Papua New Guinea after Administration of Three-Monthly Doses of Dihydroartemisinin–Piperaquine

Author

Millat-Martínez, Pere, primary, Salman, Sam, additional, Moore, Brioni R., additional, Baro, Bàrbara, additional, Page-Sharp, Madhu, additional, Batty, Kevin T., additional, Robinson, Leanne J., additional, Pomat, William, additional, Karunajeewa, Harin, additional, Laman, Moses, additional, Manning, Laurens, additional, Mitjà, Oriol, additional, and Bassat, Quique, additional

Published
2022
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11. Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Author

Rokx, Casper, Lammers, Jolanda, Buitenhuis, Lonneke, Postma, Douwe, Koster, David, Lukens, Michaèl, Scholtens, Thea, Boomgaard, Maartje van den, Kampschreur, Linda, Ubals, Maria, Prat, Núria, Díez Sánchez, Beatriz, Vértiz Guidotti, Thatiana, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, Ancochea, Àgueda, Ferrer, Magí, Videla, Sebas, Gudiol, Carlota, Fernández Rivas, Gema, CoV-Early Study Group, Vonderen, Marit van, Bianco, Andrea Sofia, Bravo, Anna, Otero, Aurema, Ruibal Suarez, Jose Carlos, Benavent, Sergio, Zarauza Pellejero, Alvaro, Línio, Rosa, Malchair, Pierre, Llopis Roca, Ferran, Blanco, Julian, Rodriguez Cortez, Orlando, Casares Gonzalez, Pablo, Arcos Vila, Gemma, García, Yolanda, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Koopmans, Marion, Ara, Jordi, COnV-ert Study Group, Rodríguez Codina, Joana, Tarres García, Silvia, Blanco, Ignacio, Hernández, Águeda, González Soler, Victoria, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Grífols, Joan Ramon, Briones Zambrano, Ney Nicanor, Millan, Anna, Capdevila Jáuregui, Mar, Fornos, Miriam, Casamitjana, Natàlia, Bordoy, Antoni E., Alonso, Eva, Zwet, Erik van, Miedema, Jelle, Martinez, Núria, Ramírez Morros, Anna, Bogers, Susanne, Maglio, Laura Analía, Amado Simon, Rosa, Comellas Fernandez, Laura, Garcia, Nadia, Ruiz Comellas, Anna, Baro, Bàrbara, Hernández, Luis, Viozquez Meya, Maria, Costes, Gèlia, Pradenas, Edwars, Forcada, Anna, Ginneken, Betty van, Harvala, Heli, Marfil, Silvia, Troxel, Andrea, Mooijaart, Simon, Trinité, Benjamin, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Russcher, Henk, Marks, Michael, Zwaginga, Jaap Jan, Torrano Soler, Pamela, Mitjà, Oriol, Rijnders, Bart J. A., Droog, José de, Corbacho Monné, Marc, Scherpenisse, Cees, Hollander, Jan den, Gharbharan, Arvind, Jordans, Carlijn, Geurtsvankessel, Corine, Albersen, Arjan, Papageourgiou, Grigorios, Katsikis, Peter, Vall Mayans, Martí, Müller, Yvonne, Reusken, Chantal, San José, Alba, Ferrer, Susana, Engen, Rene van, Karisli, Ayten, Götz, Hannelore, Struik, Jelle, París, Alexa, Suñer Navarro, Clara, Clotet, Bonaventura, 1953, Reimerink, Johan, Rokx-Niemantsverdriet, Lotte, Rodriguez Arias, Miquel Angel, Jiménez, Zahida, Verstijnen, Jose, Geloven, Nan van, Groeneveld, Geert, Zwaginga, Lisa, Oud, Josine, Meier, Romy, González Beiras, Camila, Swaneveld, Francis, Ramírez Viaplana, Ferran, Schoot, Ellen van der, Vrielink, Hans, Flores Aguilera, Begoña, Vivero Larraza, Ainhoa, Watering, Leo van de, Hogema, Boris, González García, David, Wijngaarden, Peter van, Vidal Alaball, Josep, Etten, Ronald van, Gammeren, Adriaan van, Alemany, Andrea, Puig, Jordi, Maas, Nanda, Berg – Rahman, Juliette van der, Karim, Faiz, Hiddema, Siepke, Elst, Kim van, García García, Vanesa, Casañ Lopez, Cristina, Leeuwen-Segarceanu, Elena van, Nieto, Aroa, Rodríguez Sevilla, Graciela, Reitsma, Annette, Molenkamp, Karin, Soetekouw, Robert, Band, Caterina, Carceles Peiró, Victor, Gallardo, Mireia, Galvan Femenia, Ivan, Comas Leon, Xavier, Millat Martínez, Pere, Bassat Orellana, Quique, González, María Isabel, Verdaguer, Joaquim, Roquer López, Clàudia, Contreras, Enric, Giménez, Montserrat, Ouchi, Dan, Blanco Guillermo, Ignacio, Bonet Papell, Glòria, Dastis Arias, Macarena, Delgado Capel, Maria, Faculteit Medische Wetenschappen/UMCG, Internal Medicine, Medical Microbiology & Infectious Diseases, Virology, and Epidemiology

Subjects
Immunoregulació, Multidisciplinary, SARS-CoV-2, Immunization, Passive, Immunoregulation, COVID-19, General Physics and Astronomy, Bayes Theorem, General Chemistry, Middle Aged, General Biochemistry, Genetics and Molecular Biology, Treatment Outcome, Outpatients, Humans, Multicenter Studies as Topic, COVID-19 Serotherapy, Randomized Controlled Trials as Topic
Abstract

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when Trial registration: Clinicaltrials.gov NCT04621123 and NCT04589949. Registration: NCT04621123 and NCT04589949 on https://www.clinicaltrials.gov

Published
2022

12. Low transmission of SARS-CoV-2 derived from children in family clusters: An observational study of family households in the Barcelona Metropolitan Area, Spain

Author

Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. BIOCOM-SC - Biologia Computacional i Sistemes Complexos, Mele-Casas, Maria, Launes, Cristian, Fernández de Sevilla, Mariona, Bassat, Quique, Fumadó, Victoria, Garcia-Miquel, Aleix, Bonet-Carné, Elisenda, Prats Soler, Clara, Ajanovic, Sara, Jou Muñoz, Cristina, Balanza, Nuria, Baro, Barbara, Millat-Martínez, Pere, Alonso Muñoz, Sergio, Álvarez Lacalle, Enrique, Català Sabaté, Martí, Cuadras, Daniel, Muñoz-Almagro, Carmen, Gratacós Solsona, Eduard, Jordan Garcia, Iolanda, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. BIOCOM-SC - Biologia Computacional i Sistemes Complexos, Mele-Casas, Maria, Launes, Cristian, Fernández de Sevilla, Mariona, Bassat, Quique, Fumadó, Victoria, Garcia-Miquel, Aleix, Bonet-Carné, Elisenda, Prats Soler, Clara, Ajanovic, Sara, Jou Muñoz, Cristina, Balanza, Nuria, Baro, Barbara, Millat-Martínez, Pere, Alonso Muñoz, Sergio, Álvarez Lacalle, Enrique, Català Sabaté, Martí, Cuadras, Daniel, Muñoz-Almagro, Carmen, Gratacós Solsona, Eduard, and Jordan Garcia, Iolanda

Abstract

Background: Family clusters offer a good opportunity to study viral transmission in a stable setting. We aimed to analyze the specific role of children in transmission of SARS-CoV-2 within households. Methods: A prospective, longitudinal, observational study, including children with documented acute SARS-CoV-2 infection attending 22 summer-schools in Barcelona, Spain, was performed. Moreover, other patients and families coming from other school-like environments that voluntarily accessed the study were also studied. A longitudinal follow-up (5 weeks) of the family clusters was conducted to determine whether the children considered to be primary cases were able to transmit the virus to other family members. The household reproduction number (Re*) and the secondary attack rate (SAR) were calculated. Results: 1905 children from the summer schools were screened for SARS-CoV-2 infection and 22 (1.15%) tested positive. Moreover, 32 additional children accessed the study voluntarily. Of these, 37 children and their 26 households were studied completely. In half of the cases (13/26), the primary case was considered to be a child and secondary transmission to other members of the household was observed in 3/13, with a SAR of 14.2% and a Re* of 0.46. Conversely, the SAR of adult primary cases was 72.2% including the kids that gave rise to the contact tracing study, and 61.5% without them, and the estimated Re* was 2.6. In 4/13 of the paediatric primary cases (30.0%), nasopharyngeal PCR was persistently positive > 1 week after diagnosis, and 3/4 of these children infected another family member (p<0.01). Conclusions: Children may not be the main drivers of the infection in household transmission clusters in the study population. A prolonged positive PCR could be associated with higher transmissibility., Peer Reviewed, Objectius de Desenvolupament Sostenible::3 - Salut i Benestar, Postprint (published version)

Published
2022

13. Self-collected mid-nasal swabs and saliva specimens, compared with nasopharyngeal swabs, for SARS-CoV-2 detection in mild COVID-19 patients

Author

Alemany, Andrea, Millat-Martinez, Pere, Ouchi, Dan, Corbacho-Monné, Marc, Bordoy, Antoni E., Esteban, Cristina, Hernández, Águeda, Casañ, Cristina, Gonzalez, Victoria, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Ara, Jordi, Prat, Núria, Clotet, Bonaventura, Bassat, Quique, Gimenez, Montserrat, Blanco, Ignacio, Baro, Bàrbara, and Mitjà, Oriol

Published
2021
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14. Multiplex Antibody Analysis of IgM, IgA and IgG to SARS-CoV-2 in Saliva and Serum From Infected Children and Their Close Contacts

Author

Dobaño, Carlota, primary, Alonso, Selena, additional, Vidal, Marta, additional, Jiménez, Alfons, additional, Rubio, Rocío, additional, Santano, Rebeca, additional, Barrios, Diana, additional, Pons Tomas, Gemma, additional, Melé Casas, María, additional, Hernández García, María, additional, Girona-Alarcón, Mònica, additional, Puyol, Laura, additional, Baro, Barbara, additional, Millat-Martínez, Pere, additional, Ajanovic, Sara, additional, Balanza, Núria, additional, Arias, Sara, additional, Rodrigo Melero, Natalia, additional, Carolis, Carlo, additional, García-Miquel, Aleix, additional, Bonet-Carné, Elisenda, additional, Claverol, Joana, additional, Cubells, Marta, additional, Fortuny, Claudia, additional, Fumadó, Victoria, additional, Codina, Anna, additional, Bassat, Quique, additional, Muñoz-Almagro, Carmen, additional, Fernández de Sevilla, Mariona, additional, Gratacós, Eduard, additional, Izquierdo, Luis, additional, García-García, Juan José, additional, Aguilar, Ruth, additional, Jordan, Iolanda, additional, and Moncunill, Gemma, additional

Published
2022
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15. How Did the COVID-19 Lockdown Affect Children and Adolescent's Well-Being: Spanish Parents, Children, and Adolescents Respond

Author

Ajanovic, Sara, primary, Garrido-Aguirre, Jon, additional, Baro, Bàrbara, additional, Balanza, Núria, additional, Varo, Rosauro, additional, Millat-Martínez, Pere, additional, Arias, Sara, additional, Fonollosa, Jordi, additional, Perera-Lluna, Alexandre, additional, Jordan, Iolanda, additional, Muñoz-Almagro, Carmen, additional, Bonet-Carne, Elisenda, additional, Crosas-Soler, Aina, additional, Via, Esther, additional, Nafria, Begonya, additional, García-García, Juan José, additional, and Bassat, Quique, additional

Published
2021
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16. Additional file 1 of Coverage, determinants of use and repurposing of long-lasting insecticidal nets two years after a mass distribution in Lihir Islands, Papua New Guinea: a cross-sectional study

Author

Millat-Martínez, Pere, Gabong, Rebecca, Balanza, Núria, Luana, Sakaia, Sanz, Sergi, Raulo, Silvia, Elizah, Arthur, Wali, Chilaka, Paivu, Benjamin, Dalmas, Julian, Tabie, Samson, Karl, Stephan, Laman, Moses, Pomat, William, Mitjà, Oriol, Baro, Bàrbara, and Bassat, Quique

Abstract

Additional file 1: Data collection tool used by the village malaria assistants (VMA) tocollect information for this survey.

Published
2021
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17. Additional file 2 of Coverage, determinants of use and repurposing of long-lasting insecticidal nets two years after a mass distribution in Lihir Islands, Papua New Guinea: a cross-sectional study

Author

Millat-Martínez, Pere, Gabong, Rebecca, Balanza, Núria, Luana, Sakaia, Sanz, Sergi, Raulo, Silvia, Elizah, Arthur, Wali, Chilaka, Paivu, Benjamin, Dalmas, Julian, Tabie, Samson, Karl, Stephan, Laman, Moses, Pomat, William, Mitjà, Oriol, Baro, Bàrbara, and Bassat, Quique

Abstract

Additional file 2: Definitions of the LLIN ownership and use indicators, used for thedata analysis.

Published
2021
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18. How did the COVID-19 lockdown affect children and adolescent's well-being: Spanish parents, children, and adolescents respond

Author

Universitat Politècnica de Catalunya. Centre de Recerca en Enginyeria Biomedica, Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya. B2SLab - Bioinformatics and Biomedical Signals Laboratory, Ajanovic, Sara, Garrido de Aguirre, Jon, Baro, Barbara, Balanza, Nuria, Varo, Rosauro, Millat-Martínez, Pere, Arias Sánchez, Saray, Fonollosa Magrinyà, Jordi, Perera Lluna, Alexandre, Jordan Garcia, Iolanda, Muñoz-Almagro, Carmen, Bonet-Carné, Elisenda, Crosas-Soler, Aina, Via, Esther, Nafria Escalera, Begonya, García-García, Juan José, Bassat, Quique, Universitat Politècnica de Catalunya. Centre de Recerca en Enginyeria Biomedica, Universitat Politècnica de Catalunya. Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial, Universitat Politècnica de Catalunya. B2SLab - Bioinformatics and Biomedical Signals Laboratory, Ajanovic, Sara, Garrido de Aguirre, Jon, Baro, Barbara, Balanza, Nuria, Varo, Rosauro, Millat-Martínez, Pere, Arias Sánchez, Saray, Fonollosa Magrinyà, Jordi, Perera Lluna, Alexandre, Jordan Garcia, Iolanda, Muñoz-Almagro, Carmen, Bonet-Carné, Elisenda, Crosas-Soler, Aina, Via, Esther, Nafria Escalera, Begonya, García-García, Juan José, and Bassat, Quique

Abstract

Background: During the COVID-19 pandemic, lockdown strategies have been widely used to contain SARS-CoV-2 virus spread. Children and adolescents are especially vulnerable to suffering psychological effects as result of such measures. In Spain, children were enforced to a strict home lockdown for 42 days during the first wave. Here, we studied the effects of lockdown in children and adolescents through an online questionnaire. Methods: A cross-sectional study was conducted in Spain using an open online survey from July (after the lockdown resulting from the first pandemic wave) to November 2020 (second wave). We included families with children under 16 years-old living in Spain. Parents answered a survey regarding the lockdown effects on their children and were instructed to invite their children from 7 to 16 years-old (mandatory scholar age in Spain) to respond a specific set of questions. Answers were collected through an application programming interface system, and data analysis was performed using R. Results: We included 1,957 families who completed the questionnaires, covering a total of 3,347 children. The specific children’s questionnaire was completed by 167 kids (7–11 years-old), and 100 adolescents (12–16 years-old). Children, in general, showed high resilience and capability to adapt to new situations. Sleeping problems were reported in more than half of the children (54%) and adolescents (59%), and these were strongly associated with less time doing sports and spending more than 5 h per day using electronic devices. Parents perceived their children to gain weight (41%), be more irritable and anxious (63%) and sadder (46%). Parents and children differed significantly when evaluating children’s sleeping disturbances. Conclusions: Enforced lockdown measures and isolation can have a negative impact on children and adolescent’s mental health and well-being. In future waves of the current pandemic, or in the light of potential epidemics of new emerging infecti, Peer Reviewed, Postprint (published version)

Published
2021

20. Electrocardiographic Safety of Repeated Monthly Dihydroartemisinin-Piperaquine as a Candidate for Mass Drug Administration

Author

Millat-Martínez, Pere, primary, Ila, Rhoda, additional, Laman, Moses, additional, Robinson, Leanne, additional, Karunajeewa, Harin, additional, Abel, Haina, additional, Pulai, Kevin, additional, Sanz, Sergi, additional, Manning, Laurens, additional, Moore, Brioni, additional, Bassat, Quique, additional, and Mitjà, Oriol, additional

Published
2018
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