361 results on '"Miles, Douglas"'
Search Results
2. Transcription and FACT facilitate the restoration of replication-coupled chromatin assembly defects
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Barrientos-Moreno, Marta, Maya-Miles, Douglas, Murillo-Pineda, Marina, Fontalva, Sara, Pérez-Alegre, Mónica, Andujar, Eloísa, and Prado, Félix
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- 2023
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3. Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis
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Lamas-Paz, Arantza, Hionides-Gutiérrez, Alejandro, Guo, Feifei, Jorquera, Gonzalo, Morán-Blanco, Laura, Benedé-Ubieto, Raquel, Mesquita, Mariana, Estévez-Vázquez, Olga, Zheng, Kang, Mazariegos, Marina, Vázquez-Ogando, Elena, Blázquez-López, Elena, Asensio, Iris, Mutlu, Beste, Gomez-Santos, Beatriz, Peligros, María Isabel, Vaquero, Javier, Bañares, Rafael, Delgado, Teresa C., Martínez-Chantar, María Luz, Martínez-Naves, Eduardo, Sanz-García, Carlos, Mohamed, Mohamed Ramadan, Tesolato, Sofía, Iniesta, Pilar, Gallego-Durán, Rocío, Maya-Miles, Douglas, Ampuero, Javier, Romero-Gómez, Manuel, Martínez-Alcocer, Ana, Sanfeliu-Redondo, David, Fernández-Iglesias, Anabel, Gracia-Sancho, Jordi, Coll, Mar, Graupera, Isabel, Ginès, Pere, Ciudin, Andrea, Rivera-Esteban, Jesús, Pericàs, Juan M., Ávila, Matías A., Frutos, Maria José, Martínez-Cáceres, Carlos Manuel, Ramos-Molina, Bruno, Aspichueta, Patricia, Puigserver, Pere, Nevzorova, Yulia A., and Cubero, Francisco Javier
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- 2024
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4. Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)
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Alvarado-Tapias, Edilmar, Maya-Miles, Douglas, Albillos, Agustin, Aller, Rocio, Ampuero, Javier, Andrade, Raul J., Arechederra, Maria, Aspichueta, Patricia, Banales, Jesus M., Blas-García, Ana, Caparros, Esther, Cardoso Delgado, Teresa, Carrillo-Vico, Antonio, Claria, Joan, Cubero, Francisco Javier, Díaz-Ruiz, Alberto, Fernández-Barrena, Maite G., Fernández-Iglesias, Anabel, Fernández-Veledo, Sonia, Francés, Ruben, Gallego-Durán, Rocío, Gracia-Sancho, Jordi, Irimia, Manuel, Lens, Sabela, Martínez-Chantar, María Luz, Mínguez, Beatriz, Muñoz-Hernández, Rocío, Nogueiras, Rubén, Ramos-Molina, Bruno, Riveiro-Barciela, Mar, Rodríguez-Perálvarez, Manuel L., Romero-Gómez, Manuel, Sabio, Guadalupe, Sancho-Bru, Pau, Ventura-Cots, Meritxell, Vidal, Silvia, and Gahete, Manuel D.
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- 2024
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5. aProceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)
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Tapias, Edilmar Alvarado, primary, Miles, Douglas Maya, additional, Albillos, Agustin, additional, Aller, Rocio, additional, Ampuero, Javier, additional, Andrade, Raul, additional, Arechederra, Maria, additional, Aspichueta, Patricia, additional, Banales, Jesus M, additional, García, Ana Blas, additional, Caparros, Esther, additional, Delgado, Teresa Cardoso, additional, Vico, Antonio Carrillo, additional, Claria, Joan, additional, Cubero, Francisco Javier, additional, Ruiz, Alberto Díaz, additional, Fernández-Barrena, Maite G, additional, Iglesias, Anabel Fernández, additional, Veledo, Sonia Fernández, additional, Francés, Ruben, additional, Durán, Rocío Gallego, additional, Sancho, Jordi Gracia, additional, Irimia, Manuel, additional, Lens, Sabela, additional, Martínez-Chantar, María Luz, additional, Mínguez, Beatriz, additional, Hernández, Rocío Muñoz, additional, Nogueiras, Rubén, additional, Molina, Bruno Ramos, additional, Barciela, Mar Riveiro, additional, Rodríguez-Perálvarez, Manuel L, additional, Gómez, Manuel Romero, additional, Sabio, Guadalupe, additional, Bru, Pau Sancho, additional, Cots, Meritxell Ventura, additional, Vidal, Silvia, additional, and Gahete, Manuel D, additional
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- 2024
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6. Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD
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Ampuero, Javier, Gallego-Durán, Rocío, Maya-Miles, Douglas, Montero, Rocío, Gato, Sheila, Rojas, Ángela, Gil, Antonio, Muñoz, Rocío, and Romero-Gómez, Manuel
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- 2022
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7. Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
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Gallego-Durán, Rocío, Ampuero, Javier, Pastor-Ramírez, Helena, Álvarez-Amor, Leticia, del Campo, Jose Antonio, Maya-Miles, Douglas, Montero-Vallejo, Rocío, Cárdenas-García, Antonio, Pareja, Mª Jesús, Gato-Zambrano, Sheila, Millán, Raquel, del Carmen Rico, María, Luque-Sierra, Amparo, Gil-Gómez, Antonio, Rojas, Ángela, Muñoz-Hernández, Rocío, García-Lozano, María, Aller, Rocío, Andrade, Raúl J., García-Monzón, Carmelo, Andreola, Fausto, Martín, Francisco, Jalan, Rajiv, and Romero-Gómez, Manuel
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- 2022
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8. Fibroblast growth factor 21 is a hepatokine involved in MASLD progression
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Gallego‐Durán, Rocío, Ampuero, Javier, Maya‐Miles, Douglas, Pastor‐Ramírez, Helena, Montero‐Vallejo, Rocío, Rivera‐Esteban, Jesús, Álvarez‐Amor, Leticia, Pareja, María Jesús, Rico, María Carmen, Millán, Raquel, Robles‐Frías, María José, Aller, Rocío, Rojas, Ángela, Muñoz‐Hernández, Rocío, Gil‐Gómez, Antonio, Gato, Sheila, García‐Lozano, María, Arias‐Loste, María Teresa, Abad, Javier, Calleja, José Luis, Andrade, Raúl J., Crespo, Javier, González‐Rodríguez, Águeda, García‐Monzón, Carmelo, Andreola, Fausto, Pericás, Juan Manuel, Jalan, Rajiv, Martín‐Bermudo, Francisco, and Romero‐Gómez, Manuel
- Abstract
We aimed to assess the role of FGF21 in metabolic dysfunction‐associated steatotic liver disease (MASLD) at a multi‐scale level. We used human MASLD pathology samples for FGF21 gene expression analyses (qPCR and RNAseq), serum to measure circulating FGF21 levels and DNA for genotyping the FGF21 rs838133 variant in both estimation and validation cohorts. A hepatocyte‐derived cell line was exposed to free fatty acids at different timepoints. Finally, C57BL/6J mice were fed a high‐fat and choline‐deficient diet (CDA‐HFD) for 16 weeks to assess hepatic FGF21 protein expression and FGF21 levels by ELISA. A significant upregulation in FGF21 mRNA expression was observed in the liver analysed by both qPCR (fold change 5.32 ± 5.25 vs. 0.59 ± 0.66; p= 0.017) and RNA‐Seq (3.5 fold; FDR: 0.006; p< 0.0001) in MASLD patients vs. controls. Circulating levels of FGF21 were increased in patients with steatohepatitis vs. bland steatosis (386.6 ± 328.9 vs. 297.9 ± 231.5 pg/mL; p= 0.009). Besides, sex, age, A‐allele from FGF21, GG genotype from PNPLA3, ALT, type 2 diabetes mellitus and BMI were independently associated with MASH and significant fibrosis in both estimation and validation cohorts. In vitro exposure of Huh7.5 cells to high concentrations of free fatty acids (FFAs) resulted in overexpression of FGF21 (p< 0.001). Finally, Circulating FGF21 levels and hepatic FGF21 expression were found to be significantly increased (p< 0.001) in animals under CDA‐HFD. Hepatic and circulating FGF21 expression was increased in MASH patients, in Huh7.5 cells under FFAs and in CDA‐HFD animals. The A‐allele from the rs838133 variant was also associated with an increased risk of steatohepatitis and significant and advanced fibrosis in MASLD patients.
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- 2024
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9. Novel insights into metabolic-associated steatotic liver disease preclinical models
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Junta de Andalucía, Instituto de Salud Carlos III, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Sociedad Andaluza de Patología Digestiva, European Association for the Study of the Liver, Asociación Española para el Estudio del Hígado, Montero-Vallejo, Rocío, Maya-Miles, Douglas, Ampuero, Javier, Martín, Franz, Romero-Gómez, Manuel, Gallego-Durán, Rocío, Junta de Andalucía, Instituto de Salud Carlos III, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Sociedad Andaluza de Patología Digestiva, European Association for the Study of the Liver, Asociación Española para el Estudio del Hígado, Montero-Vallejo, Rocío, Maya-Miles, Douglas, Ampuero, Javier, Martín, Franz, Romero-Gómez, Manuel, and Gallego-Durán, Rocío
- Abstract
Metabolic-associated steatotic liver disease (MASLD) encompasses a wide spectrum of metabolic conditions associated with an excess of fat accumulation in the liver, ranging from simple hepatic steatosis to cirrhosis and hepatocellular carcinoma. Finding appropriate tools to study its development and progression is essential to address essential unmet therapeutic and staging needs. This review discusses advantages and shortcomings of different dietary, chemical and genetic factors that can be used to mimic this disease and its progression in mice from a hepatic and metabolic point of view. Also, this review will highlight some additional factors and considerations that could have a strong impact on the outcomes of our model to end up providing recommendations and a checklist to facilitate the selection of the appropriate MASLD preclinical model based on clinical aims.
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- 2024
10. Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis
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Ampuero, Javier, Sanchez, Yolanda, Garcia-Lozano, Maria Rosario, Maya-Miles, Douglas, and Gomez, Manuel Romero
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- 2021
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11. Novel insights into metabolic‐associated steatotic liver disease preclinical models
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Montero‐Vallejo, Rocío, primary, Maya‐Miles, Douglas, additional, Ampuero, Javier, additional, Martín, Franz, additional, Romero‐Gómez, Manuel, additional, and Gallego‐Durán, Rocío, additional
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- 2024
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12. P18 Glutaminolysis and Steatosis to Steatohepatitis Transition: Role of Glutaminase
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García-Fernández, Vanessa, primary, Gómez, Antonio Gil, additional, Rojas, Ángela, additional, Muñoz-Hernández, Rocío, additional, Gato, Sheila, additional, Montero-Vallejo, Rocío, additional, Gallego-Durán, Rocío, additional, Maya-Miles, Douglas, additional, Rico, María del Carmen, additional, Ampuero, Javier, additional, and Romero-Gómez, Manuel, additional
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- 2023
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13. Histone stress: an unexplored source of chromosomal instability in cancer?
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Miles, Douglas Maya, Desdouets, Chantal, and Géli, Vincent
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- 2019
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14. MASLD biomarkers: Are we facing a new era?
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Maya-Miles, Douglas, Ampuero, Javier, Martí-Aguado, David, Conthe, Andrés, and Gallego-Durán, Rocío
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- 2024
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15. Endothelial and platelet-derived microvesicles as a biomarker of cardiovascular risk in patients with metabolic dysfunction-associated fatty liver disease (MAFLD)
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Zambrano, Sheila Gato, primary, Hernandez, Rocio Munoz, additional, Montero-Vallejo, Rocío, additional, del Carmen Rico, María, additional, Fernández, Vanessa García, additional, Alvarez-Ossorio, Angela Rojas, additional, Gil-Gomez, Antonio, additional, Gallego, Javier, additional, Gallego-Durán, Rocío, additional, Miles, Douglas Maya, additional, Ampuero, Javier, additional, and Gomez, Manuel Romero, additional
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- 2023
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16. Hepatitis C Virus Clearance by Direct-Acting Antivirals Agents Improves Endothelial Dysfunction and Subclinical Atherosclerosis: HEPCAR Study
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Muñoz-Hernández, Rocío, Ampuero, Javier, Millán, Raquel, Gil-Gómez, Antonio, Rojas, Ángela, Macher, Hada C., Gallego-Durán, Rocío, Gato, Sheila, Montero-Vallejo, Rocío, Rico, María C., Maya-Miles, Douglas, Sánchez-Torrijos, Yolanda, Soria, Isabel Carmona, Stiefel, Pablo, and Romero-Gómez, Manuel
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- 2020
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17. Transcription and FACT facilitate the restoration of replication-coupled chromatin assembly defects
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Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Junta de Andalucía, Barrientos-Moreno, Marta, Maya-Miles, Douglas, Murillo-Pineda, Marina, Fontalva, Sara, Pérez-Alegre, Mónica, Andújar, Eloísa, Prado, Félix, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Junta de Andalucía, Barrientos-Moreno, Marta, Maya-Miles, Douglas, Murillo-Pineda, Marina, Fontalva, Sara, Pérez-Alegre, Mónica, Andújar, Eloísa, and Prado, Félix
- Abstract
Genome duplication occurs through the coordinated action of DNA replication and nucleosome assembly at replication forks. Defective nucleosome assembly causes DNA lesions by fork breakage that need to be repaired. In addition, it causes a loss of chromatin integrity. These chromatin alterations can be restored, even though the mechanisms are unknown. Here, we show that the process of chromatin restoration can deal with highly severe chromatin defects induced by the absence of the chaperones CAF1 and Rtt106 or a strong reduction in the pool of available histones, and that this process can be followed by analyzing the topoisomer distribution of the 2µ plasmid. Using this assay, we demonstrate that chromatin restoration is slow and independent of checkpoint activation, whereas it requires the action of transcription and the FACT complex. Therefore, cells are able to ¿repair¿ not only DNA lesions but also chromatin alterations associated with defective nucleosome assembly
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- 2023
18. A second update on mapping the human genetic architecture of COVID-19
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Kanai, M, Andrews, S, Cordioli, M, Stevens, C, Neale, B, Daly, M, Ganna, A, Pathak, G, Iwasaki, A, Karjalainen, J, Mehtonen, J, Pirinen, M, Chwialkowska, K, Trankiem, A, Balaconis, M, Veerapen, K, Wolford, B, Ahmad, H, von Hohenstaufen Puoti, K, Boer, C, Boua, P, Butler-Laporte, G, Cadilla, C, Chwiałkowska, K, Colombo, F, Douillard, V, Dueker, N, Dutta, A, El-Sherbiny, Y, Eltoukhy, M, Esmaeeli, S, Faucon, A, Fave, M, Cadenas, I, Francescatto, M, Francioli, L, Franke, L, Fuentes, M, Durán, R, Cabrero, D, Harry, E, Jansen, P, Szentpéteri, J, Kaja, E, Kirk, C, Kousathanas, A, Krieger, J, Patel, S, Lemaçon, A, Limou, S, Lió, P, Marouli, E, Marttila, M, Medina-Gómez, C, Michaeli, Y, Migeotte, I, Mondal, S, Moreno-Estrada, A, Moya, L, Nakanishi, T, Nasir, J, Pasko, D, Pearson, N, Pereira, A, Priest, J, Prijatelj, V, Prokić, I, Teumer, A, Várnai, R, Romero-Gómez, M, Roos, C, Rosenfeld, J, Ruolin, L, Schulte, E, Schurmann, C, Sedaghati-khayat, B, Shaheen, D, Shivanathan, I, Sipeky, C, Sirui, Z, Striano, P, Tanigawa, Y, Remesal, A, Vadgama, N, Vallerga, C, van der Laan, S, Verdugo, R, Wang, Q, Wei, Z, Zainulabid, U, Zárate, R, Auton, A, Shelton, J, Shastri, A, Weldon, C, Filshtein-Sonmez, T, Coker, D, Symons, A, Aslibekyan, S, O’Connell, J, Ye, C, Hatoum, A, Agrawal, A, Bogdan, R, Colbert, S, Thompson, W, Fan, C, Johnson, E, Niazyan, L, Davidyants, M, Arakelyan, A, Avetyan, D, Bekbossynova, M, Tauekelova, A, Tuleutayev, M, Sailybayeva, A, Ramankulov, Y, Zholdybayeva, E, Dzharmukhanov, J, Kassymbek, K, Tsechoeva, T, Turebayeva, G, Smagulova, Z, Muratov, T, Khamitov, S, Kwong, A, Timpson, N, Niemi, M, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Gofflot, S, Bouysran, Y, Busson, A, Peyrassol, X, Wilkin, F, Pichon, B, Smits, G, Vandernoot, I, Goffard, J, Tiembe, N, Morrison, D, Afilalo, J, Mooser, V, Richards, J, Rousseau, S, Durand, M, Forgetta, V, Laurent, L, Afrasiabi, Z, Bouab, M, Tselios, C, Xue, X, Afilalo, M, Oliveira, M, St-Cyr, J, Boisclair, A, Ragoussis, J, Auld, D, Kaufmann, D, Lathrop, G, Bourque, G, Décary, S, Falcone, E, Montpetit, A, Piché, A, Renoux, C, Tremblay, K, Tse, S, Zawati, M, Davis, L, Cox, N, Below, J, Sealock, J, Shuey, M, Polikowsky, H, Petty, L, Shaw, D, Chen, H, Zhu, W, Schmidt, A, Ludwig, K, Maj, C, Rolker, S, Balla, D, Behzad, P, Nöthen, M, Fazaal, J, Keitel, V, Jensen, B, Feldt, T, Marx, N, Dreher, M, Pink, I, Cornberg, M, Illig, T, Lehmann, C, Schommers, P, Rybniker, J, Augustin, M, Knopp, L, Kurth, I, Eggermann, T, Volland, S, Berger, M, Brenner, T, Hinney, A, Witzke, O, Konik, M, Bals, R, Herr, C, Ludwig, N, Walter, J, Latz, E, Schmidt, S, Brooks, J, Bull, S, Elliott, L, Gagnon, F, Greenwood, C, Hung, R, Lawless, J, Paterson, A, Sun, L, Rauh, M, Briollais, L, Gingras, A, Bombard, Y, Pugh, T, Simpson, J, Goneau, L, Halevy, A, Maslove, D, Borgundvaag, B, Devine, L, Bearss, E, Richardson, D, Arnoldo, S, Friedman, S, Taher, A, Stern, S, Dagher, M, Vasilevska-Ristovska, J, Biggs, C, Mickiewicz, B, Strug, L, Scherer, S, Aziz, N, Jones, S, Knoppers, B, Lathrop, M, Turvey, S, Yeung, R, Allen, U, Cheung, A, Herridge, M, Hunt, M, Lerner-Ellis, J, Taher, J, Parekh, R, Hiraki, L, Cowan, J, Ducharme, F, Ostrowski, M, Bernier, F, Kellner, J, Garg, E, Yoo, S, Vlasschaert, C, Frangione, E, Chung, M, Noor, A, Greenfeld, E, Colwill, K, Clausen, M, Chao, G, Yue, F, Fritzler, M, Whitney, J, Thiruvahindrapuram, B, Garant, J, Abraham, R, Davis, A, Campigotto, A, Papenburg, J, Niranjan, K, Betschel, S, Sadarangani, M, Barton-Forbes, M, Hanley, M, Fung, C, Lapadula, E, Macdonald, G, Puopolo, M, Kaushik, D, Nirmalanathan, K, Wong, I, Khan, Z, Zarei, N, Michalowska, M, Modi, B, Persia, P, Estacio, A, Buchholz, M, Cheatley, P, Lorenti, M, Aman, N, Matveev, V, Budylowski, P, Upton, J, Morris, S, Boyd, T, Chowdhary, S, Casalino, S, Morgan, G, Mighton, C, Mcgeer, A, Mazzulli, T, Mcleod, S, Binnie, A, Faghfoury, H, Chertkow, H, Racher, H, Serbanescu, M, Pavenski, K, Esser, M, Thompson, G, Herbrick, J, Gignoux, C, Wicks, S, Crooks, K, Barnes, K, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Schulze, T, Heilbronner, U, Papiol, S, Corbetta, A, Wendtner, C, Spinner, C, Erber, J, Schneider, J, Winter, C, Wiltfang, J, Budde, M, Senner, F, Kalman, J, Protzer, U, Mueller, N, Mousas, A, Liontos, A, Christaki, E, Milionis, H, Tsilidis, K, Asimakopoulos, A, Kanellopoulou, A, Markozannes, G, Biros, D, Milionis, O, Tsourlos, S, Athanasiou, L, Kolios, N, Pappa, C, Papathanasiou, A, Pargana, E, Nasiou, M, Kosmidou, M, Rapti, I, Ntotsikas, E, Chaliasos, K, Ntzani, E, Evangelou, E, Gartzonika, K, Georgiou, I, Tzoulaki, I, Ellinghaus, D, Degenhardt, F, Cáceres, M, Juzenas, S, Lenz, T, Albillos, A, Julià, A, Prati, D, Solligård, E, Garcia, F, Tran, F, Hanses, F, Baselli, G, Zoller, H, Holter, J, Fernández, J, Barretina, J, Valenti, L, Bujanda, L, Buti, M, D’Amato, M, Banales, J, Rosenstiel, P, Koehler, P, Invernizzi, P, de Cid, R, Asselta, R, Schreiber, S, Duga, S, Hehr, U, Franke, A, Maya-Miles, D, Hov, J, Karlsen, T, Folseraas, T, Teles, A, Tanck, A, Gassner, C, Azuure, C, Wacker, E, Uellendahl-Werth, F, Hemmrich-Stanisak, G, Elabd, H, Kässens, J, Arora, J, Lerga-Jaso, J, Wienbrandt, L, Rühlemann, M, Wendorff, M, Figuera Basso, M, Vadla, M, Wittig, M, Braun, N, Lenning, O, Özer, O, Myhre, R, Raychaudhuri, S, Wesse, T, Albrecht, W, Yi, X, Ortiz, A, de Salazar, A, Chercoles, A, Palom, A, Ruiz, A, Garcia-Fernandez, A, Blanco-Grau, A, Mantovani, A, Holten, A, Bandera, A, Cherubini, A, Protti, A, Aghemo, A, Gerussi, A, Ramirez, A, Nebel, A, Barreira, A, Lleo, A, Kildal, A, Biondi, A, Caballero-Garralda, A, Gori, A, Glück, A, Lind, A, Nolla, A, Latiano, A, Fracanzani, A, Peschuck, A, Cavallero, A, Dyrhol-Riise, A, Ruello, A, Muscatello, A, Voza, A, Rando-Segura, A, Solier, A, Cortes, B, Mateos, B, Nafria-Jimenez, B, Schaefer, B, Bellinghausen, C, Ferrando, C, de la Horra, C, Quereda, C, Scollo, C, Lange, C, Hu, C, Paccapelo, C, Angelini, C, Cappadona, C, Bianco, C, Cea, C, Sancho, C, Hoff, D, Galimberti, D, Haschka, D, Jiménez, D, Pestaña, D, Toapanta, D, Muñiz-Diaz, E, Azzolini, E, Sandoval, E, Binatti, E, Scarpini, E, Casalone, E, Urrechaga, E, Paraboschi, E, Pontali, E, Reverter, E, Calderón, E, Navas, E, Contro, E, Arana-Arri, E, Aziz, F, Sánchez, F, Ceriotti, F, Martinelli-Boneschi, F, Peyvandi, F, Blasi, F, Malvestiti, F, Medrano, F, Mesonero, F, Rodriguez-Frias, F, Müller, F, Bellani, G, Pesenti, A, Zanella, A, Grasselli, G, Pezzoli, G, Costantino, G, Albano, G, Cardamone, G, Bellelli, G, Citerio, G, Foti, G, Lamorte, G, Matullo, G, Kurihara, H, Neb, H, My, I, Hernández, I, de Rojas, I, Galván-Femenia, I, Afset, J, Heyckendorf, J, Damås, J, Ampuero, J, Martín, J, Erdmann, J, Badia, J, Dopazo, J, Bergan, J, Quero, J, Goikoetxea, J, Delgado, J, Guerrero, J, Risnes, K, Banasik, K, Müller, K, Gaede, K, Garcia-Etxebarria, K, Tonby, K, Heggelund, L, Bettini, L, Sumoy, L, Terranova, L, Gustad, L, Garbarino, L, Santoro, L, Téllez, L, Roade, L, Ostadreza, M, Intxausti, M, Kogevinas, M, Riveiro-Barciela, M, Schaefer, M, Gutiérrez-Stampa, M, Carrabba, M, Valsecchi, M, Hernandez-Tejero, M, Vehreschild, M, Manunta, M, Acosta-Herrera, M, D’Angiò, M, Baldini, M, Cazzaniga, M, Marquié, M, Castoldi, M, Cecconi, M, Tomasi, M, Boada, M, Joannidis, M, Mazzocco, M, Ciccarelli, M, Rodríguez-Gandía, M, Bocciolone, M, Miozzo, M, Ayo, N, Blay, N, Chueca, N, Montano, N, Martínez, N, Cornely, O, Palmieri, O, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Tentorio, P, Castro, P, Rodrigues, P, Izquierdo-Sanchez, L, España, P, Hoffmann, P, Bacher, P, de Pablo, R, Ferrer, R, Gualtierotti, R, Gallego-Durán, R, Nieto, R, Carpani, R, Morilla, R, Badalamenti, S, Haider, S, Ciesek, S, Bombace, S, Marsal, S, Klein, S, Pelusi, S, Wilfling, S, Goerg, S, Bosari, S, Brunak, S, Heilmann-Heimbach, S, Aliberti, S, Dudman, S, Zheng, T, Bahmer, T, Pumarola, T, Cejudo, T, Rimoldi, V, Monzani, V, Skogen, V, Friaza, V, Andrade, V, Moreno, V, 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C., Thompson, Wesley K., Fan, Chun Chieh, Johnson, Emma C., Niazyan, Lyudmila, Davidyants, Mher, Arakelyan, Arsen, Avetyan, Diana, Bekbossynova, Makhabbat, Tauekelova, Ainur, Tuleutayev, Mukhtar, Sailybayeva, Aliya, Ramankulov, Yerlan, Zholdybayeva, Elena, Dzharmukhanov, Jarkyn, Kassymbek, Kuat, Tsechoeva, Tatyana, Turebayeva, Gulsimzhan, Smagulova, Zauresh, Muratov, Timur, Khamitov, Sadyk, Kwong, Alex S. F., Timpson, Nicholas J., Niemi, Mari E. K., Rahmouni, Souad, Guntz, Julien, Beguin, Yves, Pigazzini, Sara, Nkambule, Lindokuhle, Georges, Michel, Moutschen, Michel, Misset, Benoit, Darcis, Gilles, Gofflot, Stéphanie, Bouysran, Youssef, Busson, Adeline, Peyrassol, Xavier, Wilkin, Françoise, Pichon, Bruno, Smits, Guillaume, Vandernoot, Isabelle, Goffard, Jean-Christophe, Tiembe, Nicky, Morrison, David R., Afilalo, Jonathan, Mooser, Vincent, Richards, J. Brent, Rousseau, Simon, Durand, Madeleine, Forgetta, Vincenzo, Laurent, Laetitia, Afrasiabi, Zaman, Bouab, Meriem, Tselios, Chris, Xue, Xiaoqing, Afilalo, Marc, Oliveira, Maureen, St-Cyr, Janick, Boisclair, Ariane, Ragoussis, Jiannis, Auld, Daniel, Kaufmann, Daniel E., Lathrop, G. Mark, Bourque, Guillaume, Décary, Simon, Falcone, Emilia Liana, Montpetit, Alexandre, Piché, Alain, Renoux, Christel, Tremblay, Karine, Tse, Sze Man, Zawati, Ma’n H., Davis, Lea K., Cox, Nancy J., Below, Jennifer E., Sealock, Julia M., Faucon, Annika B., Shuey, Megan M., Polikowsky, Hannah G., Petty, Lauren E., Shaw, Douglas M., Chen, Hung-Hsin, Zhu, Wanying, Schmidt, Axel, Ludwig, Kerstin U., Maj, Carlo, Rolker, Selina, Balla, Daniella, Behzad, Pari, Nöthen, Markus M., Fazaal, Julia, Keitel, Verena, Jensen, Björn-Erik Ole, Feldt, Torsten, Marx, Nikolaus, Dreher, Michael, Pink, Isabell, Cornberg, Markus, Illig, Thomas, Lehmann, Clara, Schommers, Philipp, Rybniker, Jan, Augustin, Max, Knopp, Lisa, Kurth, Ingo, Eggermann, Thomas, Volland, Sonja, Berger, Marc M., Brenner, Thorsten, Hinney, Anke, Witzke, Oliver, Konik, Margarethe J., Bals, Robert, Herr, Christian, Ludwig, Nicole, Walter, Jörn, Latz, Eicke, Schmidt, Susanne V., Brooks, Jennifer D., Bull, Shelley, Elliott, Lloyd T., Gagnon, France, Greenwood, Celia M. T., Hung, Rayjean J., Lawless, Jerry F., Paterson, Andrew D., Sun, Lei, Rauh, Michael, Briollais, Laurent, Gingras, Anne-Claude, Bombard, Yvonne, Pugh, Trevor J., Simpson, Jared, Goneau, Lee W., Halevy, Anat R., Maslove, David M., Borgundvaag, Bjug, Devine, Luke, Bearss, Erin, Richardson, David, Arnoldo, Saranya, Friedman, Steven Marc, Taher, Ahmed, Stern, Seth, Dagher, Marc, Vasilevska-Ristovska, Jovanka, Biggs, Catherine M., Mickiewicz, Beata, Strug, Lisa J., Scherer, Stephen W., Aziz, Naveed, Jones, Steven J. M., Knoppers, Bartha M., Lathrop, Mark, Turvey, Stuart E., Yeung, Rae S. M., Allen, Upton, Cheung, Angela M., Herridge, Margaret S., Hunt, Miranda, Lerner-Ellis, Jordan, Taher, Jennifer, Parekh, Rulan S., Hiraki, Linda T., Cowan, Juthaporn, Ducharme, Francine M., Ostrowski, Mario, Bernier, Francois P., Kellner, Jim, Garg, Elika, Yoo, Samantha, Vlasschaert, Caitlyn, Frangione, Erika, Chung, Monica, Noor, Abdul, Greenfeld, Elena, Colwill, Karen, Clausen, Marc, Chao, Gary, Yue, FengYun, Fritzler, Marvin, Whitney, Joseph, Thiruvahindrapuram, Bhooma, Garant, Jean-Michel, Abraham, Rohan, Davis, Adrienne, Campigotto, Aaron, Papenburg, Jesse, Niranjan, Kissoon, Betschel, Stephen, Sadarangani, Manish, Barton-Forbes, Michelle, Hanley, Michaela, Fung, Chun Yiu Jordan, Lapadula, Elisa, MacDonald, Georgia, Puopolo, Michael, Kaushik, Deepanjali, Nirmalanathan, Konika, Wong, Iris, Khan, Zeeshan, Zarei, Natasha, Michalowska, Maria, Modi, Bhavi P., Persia, Pourshahnazari, Estacio, Antonio, Buchholz, Megan, Cheatley, Patti Lou, Lorenti, Miranda, Aman, Nowrin F., Matveev, Vitaliy, Budylowski, Patrick, Upton, Julia, Morris, Shaun, Boyd, Tracy, Chowdhary, Sunakshi, Casalino, Selina, Morgan, Gregory, Mighton, Chloe, McGeer, Allison, Mazzulli, Tony, McLeod, Shelley L., Binnie, Alexandra, Faghfoury, Hanna, Chertkow, Howard, Racher, Hilary, Serbanescu, Mihaela A., Pavenski, Katerina, Esser, Michael, Thompson, Graham, Herbrick, Jo-Anne, Gignoux, Christopher R., Wicks, Stephen J., Crooks, Kristy, Barnes, Kathleen C., Daya, Michelle, Shortt, Jonathan, Rafaels, Nicholas, Chavan, Sameer, Schulze, Thomas G., Heilbronner, Urs, Papiol, Sergi, Corbetta, Andrea, Wendtner, Clemens M., Spinner, Christoph D., Erber, Johanna, Schneider, Jochen, Winter, Christof, Wiltfang, Jens, Budde, Monika, Senner, Fanny, Kalman, Janos L., Protzer, Ulrike, Mueller, Nikola S., Mousas, Abdou, Liontos, Angelos, Christaki, Eirini, Milionis, Haralampos, Tsilidis, Konstantinos, Asimakopoulos, Alexandros, Kanellopoulou, Afroditi, Markozannes, Georgios, Biros, Dimitrios, Milionis, Orestis, Tsourlos, Stavros, Athanasiou, Lazaros, Kolios, Nikolaos-Gavriil, Pappa, Christiana, Papathanasiou, Alexandros, Pargana, Eleni, Nasiou, Maria, Kosmidou, Maria, Rapti, Iro, Ntotsikas, Evangelos, Chaliasos, Konstantinos, Ntzani, Evangelia, Evangelou, Evangelos, Gartzonika, Konstantina, Georgiou, Ioannis, Tzoulaki, Ioanna, Ellinghaus, David, Degenhardt, Frauke, Cáceres, Mario, Juzenas, Simonas, Lenz, Tobias L., Albillos, Agustín, Julià, Antonio, Prati, Daniele, Solligård, Erik, Garcia, Federico, Tran, Florian, Hanses, Frank, Baselli, Guido, Zoller, Heinz, Holter, Jan Cato, Fernández, Javier, Barretina, Jordi, Valenti, Luca, Bujanda, Luis, Buti, Maria, D’Amato, Mauro, Banales, Jesus M., Rosenstiel, Philip, Koehler, Philipp, Invernizzi, Pietro, de Cid, Rafael, Asselta, Rosanna, Schreiber, Stefan, Duga, Stefano, Hehr, Ute, Franke, Andre, Maya-Miles, Douglas, Hov, Johannes R., Karlsen, Tom H., Folseraas, Trine, Teles, Ana, Tanck, Anja, Gassner, Christoph, Azuure, Clinton, Wacker, Eike Matthias, Uellendahl-Werth, Florian, Hemmrich-Stanisak, Georg, ElAbd, Hesham, Kässens, Jan, Arora, Jatin, Lerga-Jaso, Jon, Wienbrandt, Lars, Rühlemann, Malte Christoph, Wendorff, Mareike, Figuera Basso, Maria E., Vadla, May Sissel, Wittig, Michael, Braun, Nicole, Lenning, Ole Bernt, Özer, Onur, Myhre, Ronny, Raychaudhuri, Soumya, Wesse, Tanja, Albrecht, Wolfgang, Yi, Xiaoli, Ortiz, Aaron Blandino, de Salazar, Adolfo, Chercoles, Adolfo Garrido, Palom, Adriana, Ruiz, Agustín, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Holten, Aleksander Rygh, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Nebel, Almut, Barreira, Ana, Lleo, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Nolla, Anna Carreras, Latiano, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, Muscatello, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Cortes, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Bellinghausen, Carla, Ferrando, Carlos, de la Horra, Carmen, Quereda, Carmen, Scollo, Chiara, Lange, Christoph, Hu, Cinzia, Paccapelo, Cinzia, Angelini, Claudio, Cappadona, Claudio, Bianco, Cristiana, Cea, Cristina, Sancho, Cristina, Hoff, Dag Arne Lihaug, Galimberti, Daniela, Haschka, David, Jiménez, David, Pestaña, David, Toapanta, David, Muñiz-Diaz, Eduardo, Azzolini, Elena, Sandoval, Elena, Binatti, Eleonora, Scarpini, Elio, Casalone, Elisabetta, Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, Calderón, Enrique J., Navas, Enrique, Contro, Ernesto, Arana-Arri, Eunate, Aziz, Fátima, Sánchez, Félix García, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Blasi, Francesco, Malvestiti, Francesco, Medrano, Francisco J., Mesonero, Francisco, Rodriguez-Frias, Francisco, Müller, Fredrik, Bellani, Giacomo, Pesenti, Antonio, Zanella, Alberto, Grasselli, Giacomo, Pezzoli, Gianni, Costantino, Giorgio, Albano, Giovanni, Cardamone, Giulia, Bellelli, Giuseppe, Citerio, Giuseppe, Foti, Giuseppe, Lamorte, Giuseppe, Matullo, Giuseppe, Kurihara, Hayato, Neb, Holger, My, Ilaria, Hernández, Isabel, de Rojas, Itziar, Galván-Femenia, Iván, Afset, Jan Egil, Heyckendorf, Jan, Damås, Jan Kristian, Ampuero, Javier, Martín, Javier, Erdmann, Jeanette, Badia, Joan Ramon, Dopazo, Joaquin, Bergan, Jonas, Quero, Jose Hernández, Goikoetxea, Josune, Delgado, Juan, Guerrero, Juan M., Risnes, Kari, Banasik, Karina, Müller, Karl Erik, Gaede, Karoline I., Garcia-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lars, Bettini, Laura Rachele, Sumoy, Lauro, Terranova, Leonardo, Gustad, Lise Tuset, Garbarino, Lucia, Santoro, Luigi, Téllez, Luis, Roade, Luisa, Ostadreza, Mahnoosh, Intxausti, Maider, Kogevinas, Manolis, Riveiro-Barciela, Mar, Schaefer, Marco, Gutiérrez-Stampa, María A., Carrabba, Maria, Valsecchi, Maria G., Hernandez-Tejero, María, Vehreschild, Maria J. G. T., Manunta, Maria, Acosta-Herrera, Marialbert, D’Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Marquié, Marta, Castoldi, Massimo, Cecconi, Maurizio, Tomasi, Melissa, Boada, Mercè, Joannidis, Michael, Mazzocco, Michela, Ciccarelli, Michele, Rodríguez-Gandía, Miguel, Bocciolone, Monica, Miozzo, Monica, Ayo, Natale Imaz, Blay, Natalia, Chueca, Natalia, Montano, Nicola, Martínez, Nilda, Cornely, Oliver A., Palmieri, Orazio, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Tentorio, Paolo, Castro, Pedro, Rodrigues, Pedro M., Izquierdo-Sanchez, Laura, España, Pedro Pablo, Hoffmann, Per, Bacher, Petra, de Pablo, Raúl, Ferrer, Ricard, Gualtierotti, Roberta, Gallego-Durán, Rocío, Nieto, Rosa, Carpani, Rossana, Morilla, Rubén, Badalamenti, Salvatore, Haider, Sammra, Ciesek, Sandra, Bombace, Sara, Marsal, Sara, Klein, Sebastian, Pelusi, Serena, Wilfling, Sibylle, Goerg, Siegfried, Bosari, Silvano, Brunak, Søren, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Dudman, Susanne, Zheng, Tenghao, Bahmer, Thomas, Pumarola, Tomas, Cejudo, Trinidad Gonzalez, Rimoldi, Valeria, Monzani, Valter, Skogen, Vegard, Friaza, Vicente, Andrade, Victor, Moreno, Victor, Peter, Wolfgang, Farre, Xavier, Khodamoradi, Yascha, Grimsrud, Marit M., May, Sandra, Colombo, Alicia, Virginia, Monardes-Ramírez A., Dorador, Cristina, Fuentes-Guajardo, Macarena, Silva, Andrea X., Espinosa-Parrilla, Yolanda, Yáñez, Cristian E., Retamales-Ortega, Rocío M., Saez Hidalgo, Juan M., Tobar-Calfucoy, Eduardo A., Carvajal-Silva, Laura, Martínez, Matías F., Cerpa, Leslie C., Christian, Muñoz A., Cappelli, Claudio, Valenzuela-Jorquera, Hector, Zapata-Contreras, Daniela, Zuñiga-Pacheco, Paula, Nova-Lamperti, Estefania A., Sanhueza, Sergio A., Donoso, Gerardo, Bocchieri, Pamela, Kochifas, Pia, Quiñones, Luis A., Pedersen, Ole Birger, Geller, Frank, Westergaard, David, Sequeros, Celia Burgos, Nissen, Janna, Nielsen, Susanne Dam, Feldt-Rasmussen, Ulla, Bliddal, Sofie, Grønbæk, Kirsten, Ullum, Henrik, Ostrowski, Sisse Rye, Feenstra, Bjarke, Shahin, Doaa, Sobh, Ali, Shoma, Ashraf, Nkambul, Lindokuhle, Elhadidy, Tamer A., Abd Elghafar, Mohamed S., El-Jawhari, Jehan J., Mohamed, Attia A. S., Elnagdy, Marwa H., Samir, Amr, Abdel-Aziz, Mahmoud, Khafaga, Walid T., El-Lawaty, Walaa M., Torky, Mohamed S., El-Shanshory, Mohamed R., Elzeiny, Ahmed, Rashad, Amal, Mansour, Tamer A., Yassen, Amr M., Hegazy, Mohamed A. F., Okasha, Kamal, Eid, Mohammed A., Hanteera, Moahmed S., Medina-Gomez, Carolina, Ikram, M. Arfan, Uitterlinden, Andre G., Ripatti, Samuli, Jermy, Bradley, Ruotsalainen, Sanni, Kristiansson, Kati, Koskelainen, Sami, Perola, Markus, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Kaunisto, Mari, Julienne, Hanna, Aschard, Hugues, Deleuze, Jean-Francois, Debette, Stephanie, Tregouet, David-Alexandre, Abel, Laurent, Henches, Léo, Lefloch, Edith, Claire, Dandine-Roulland, Sakuntabhai, Anavaj, Bourgeron, Thomas, Olaso, Robert, Daian, Delphine Bacq, Pellegrin, Isabelle, Casanova, Jean-Laurent, Cobat, Aurélie, Jouanguy, Emmanuelle, Zhang, Qian, Ghosn, Jade, Mentré, France, Laouénan, Cédric, Tubiana, Sarah, Chirouze, Catherine, Quintana-Murci, Luis, Patin, Etienne, Duffy, Darragh, Boland, Anne, Carreras, Anna, Galván-Femenía, Iván, Farré, Xavier, Cortés, Beatriz, Mercader, Josep Maria, Guindo-Martinez, Marta, Torrents, David, Garcia-Aymerich, Judith, Castaño-Vinyals, Gemma, Dobaño, Carlota, van Heel, David A., Hunt, Karen A., Trembath, Richard C., Jacobs, Benjamin Meir, Huang, Qin Qin, Martin, Hilary C., Mason, Dan, Trivedi, Bhavi, Wright, John, Munisamy, Malathy, Finer, Sarah, Griffiths, Christopher J., McCarthy, Mark I., Rosenberger, Carrie, Lee, Jong Eun, Chang, Diana, Hammer, Christian, Hunkapiller, Julie, Mahajan, Anubha, Pendergrass, Rion, Sucheston-Campbell, Lara, Yaspan, Brian, Lee, Hyun Soo, Shin, Eunsoon, Jang, Hye Yoon, Kim, Sunmie, Kym, Sungmin, Kim, Yeon-Sook, Jeong, Hyeongseok, Kwon, Ki Tae, Kim, Shin-Woo, Kim, Jin Yong, Jang, Young Rock, Kim, Hyun ah, Lee, Ji yeon, Lee, Jeong Eun, Lee, Shinwon, Choe, Kang-Won, Kang, Yu Min, Jee, Sun Ha, Jung, Keum Ji, Park, Hyun-Young, Kim, Bong-Jo, Kim, Young Jin, Hwang, Mi Yeong, Yoon, Kyungheon, Pairo-Castineira, Erola, Rawlik, Konrad, Caulfield, Mark J., Baillie, J. Kenneth, Griffiths, Fiona, Bretherick, Andrew D., Stuckey, Alex, Odhams, Christopher A., Walker, Susan, Russell, Clark D., Malinauskas, Tomas, Wu, Yang, Shen, Xia, Elliott, Katherine S., Morrice, Kirstie, Keating, Sean, Wang, Bo, Rhodes, Daniel, Klaric, Lucija, Zechner, Marie, Parkinson, Nick, Fawkes, Angie, Murphy, Lee, Vitart, Veronique, Wilson, James F., Yang, Jian, Scott, Richard H., Moutsianas, Loukas, Law, Andy, Begg, Colin, Hendry, Sara Clohisey, Hinds, Charles, Horby, Peter, Knight, Julian, Ling, Lowell, Maslove, David, McAuley, Danny, Millar, Johnny, Montgomery, Hugh, Nichol, Alistair, Openshaw, Peter J. M., Ponting, Chris P., Rowan, Kathy, Semple, Malcolm G., Shankar-Hari, Manu, Summers, Charlotte, Walsh, Timothy, Pan, Jacqueline, Grau, Neus, Jones, Tim Owen, Lim, Rosario, Marotti, Martina, Whitton, Christopher, Bociek, Aneta, Campos, Sara, Arbane, Gill, Ostermann, Marlies, Cha, Mina, DAmato, Fabiola, Kosifidou, Eirini, Lorah, Shelley, Morera, Kyma, Brady, Laura, Hugill, Keith, Henning, Jeremy, Bonner, Stephen, Headlam, Evie, Jones, Jessica, List, Abigail, Morley, Joanne, Welford, Amy, Kamangu, Bobette, Ratnakumar, Anitha, Shoremekun, Abiola, Alldis, Zoe, Astin-Chamberlain, Raine, Bibi, Fatima, Biddle, Jack, Blow, Sarah, Bolton, Matthew, Borra, Catherine, Bowles, Ruth, Burton, Maudrian, Choudhury, Yasmin, Cox, Amber, Easthope, Amy, Ebano, Patrizia, Fotiadis, Stavros, Gurasashvili, Jana, Halls, Rosslyn, Hartridge, Pippa, Kallon, Delordson, Kassam, Jamila, Lancoma-Malcolm, Ivone, Matharu, Maninderpal, May, Peter, Mitchelmore, Oliver, Newman, Tabitha, Patel, Mital, Pheby, Jane, Pinzuti, Irene, Prime, Zoe, Prysyazhna, Oleksandra, Shiel, Julian, Taylor, Melanie, Tierney, Carey, Zongo, Olivier, Wood, Suzanne, Zak, Anne, Collier, David, Mundy, Manuela, Thompson, Christopher, Pritchard, Lisa, Gellamucho, Minnie, Cartlidge, David, Bandla, Nageswar, Bailey, Lucy, Davies, Michelle, Delaney, Jane, Scott, Leanne, Abdelrazik, Marwa, Alasdair, Frater, Carter, David, Elhassan, Munzir, Ganesan, Arunkumar, Jenkins, Samuel, Lamond, Zoe, Purohit, Dharam, Rohit, Kumar, Saleem, Malik, Wall, Alanna, Xavier, Kugan, Bakthavatsalam, Dhanalaksmi, Gehad, Kirolos, Gnanapragasam, Pakeerathan, Jain, Kapil, Jain, Swati, Malik, Abdul, Pappachan, Naveen, Moreno-Cuesta, Jeronimo, Haldeos, Anne, Vincent, Rachel, Oziegb, Maryjane, Cavazza, Anna, Cockrell, Maeve, Corcoran, Eleanor, Depante, Maria, Finney, Clare, Jerome, Ellen, Knighton, Abigail, Nayak, Monalisa, Pappa, Evita, Saha, Rohit, Saha, Sian, Dodd, Andrew, O’Reilly, Kevin, McPhail, Mark, Clarey, Emma, Noble, Harriet, Smith, John, Coghlan, Phoebe, Brett, Stephen, Gordon, Anthony, Templeton, Maie, Antcliffe, David, Banach, Dorota, Darnell, Sarah, Fernandez, Ziortza, Jepson, Eleanor, Mohammed, Amal, Rojo, Roceld, Arias, Sonia Sousa, Gurung, Anita Tamang, Wong, Jenny, Fernandez-Roman, Jaime, Hamilton, David O., Johnson, Emily, Johnston, Brian, Martinez, Maria Lopez, Mulla, Suleman, Waite, Alicia A. C., Williams, Karen, Waugh, Victoria, Welters, Ingeborg, Emblem, Jessica, Norris, Maria, Shaw, David, Bashyal, Archana, Beer, Sally, Hutton, Paula, McKechnie, Stuart, Davidson, Neil, Mathew, Soya, Readion, Grace, Ryu, Jung, Wilson, Jean, Agrawal, Shruti, Elston, Kay, Jones, Megan, Meaney, Eoghan, Polgarova, Petra, Elbehery, Muhammad, Daubney, Esther, Ng, Anthony, Marshall, Jocelyn, Pathan, Nazima, Stroud, Katerina, White, Deborah, Andrew, Angela, Ashraf, Saima, Clark, Amy, Dent, Martin, Langley, Margaret, Peters, Cecilia, Ryan, Lucy, Sampson, Julia, Wei, Shuying, Baddeley, Alice, Meredith, Megan, Morris, Lucy, Gibbons, Alexandra, McLoughlin, Lisa, Delgado, Carlos Castro, Clark, Victoria, Dawson, Deborah, Ding, Lijun, Durrant, Georgia, Ezeobu, Obiageri, Harrison, Abiola, Hurt, William James, Kanu, Rebecca, Kinch, Ashley, Leaver, Susannah, Lisboa, Ana, Mathew, Jisha, Patel, Kamal, Saluzzio, Romina Pepermans, Rawlins, John, Samakomva, Tinashe, Shah, Nirav, Sicat, Christine, Texeira, Joana, Queiroz, Joana Gomes De, Gloria, Edna Fernandes Da, Maccacari, Elena, Yun, Nikki, Manna, Soumendu, Farnell-Ward, Sarah, Maizcordoba, Maria, Thanasi, Maria, Ali, Hawakin Haji, Hastings, Janice, Grauslyte, Lina, Hussain, Musarat, Ruge, Bobby, King, Sam, Pogreban, Tatiana, Rosaroso, Lace, Smith, Helen, Phull, Mandeep-Kaur, Adams, Nikkita, Franke, George, George, Aparna, Salciute, Erika, Wong, Joanna, Dunne, Karen, Flower, Luke, Sharland, Emma, Sra, Sukhmani, Andrew, Gillian, Callaghan, Marie, Barclay, Lucy, Marshall, Lucy, Amamio, Maria, Birch, Sophie, Briton, Kate, Clark, Sarah, Doverman, Katerine, Hope, Dave, Mcculloch, Corrienne, Simpson, Scott, Singleton, Jo, Fernandez, Rita, Allen, Meryem, Baptista, David, Crowe, Rebecca, Fox, Jonathan, Khera, Jacyntha, Loveridge, Adam, McKenley, India, Morino, Eriko, Naranjo, Andres, O’Connor, Denise, Simms, Richard, Sollesta, Kathryn, Swain, Andrew, Venkatesh, Harish, Herdman-Grant, Rosie, Joseph, Anna, Nown, Angela, Rose, Steve, Pogson, David, Boxall, Helen, Brimfield, Lutece, Claridge, Helen, Daly, Zoe, George, Shenu, Gribbin, Andrew, Cheema, Yusuf, Cutler, Sean, Richards, Owen, Roynon-Reed, Anna, Cherian, Shiney, Heron, Anne Emma, Williams, Gemma, Szakmany, Tamas, Waters, Abby, Collins, Kim, Dunhill, Jill, Jones, Ffion, Morris, Rebecca, Ship, Lucy, Cardwell, Amy, Ali, Syamlan, Bhatterjee, Ravi, Bolton, Rachel, Chukkambotla, Srikanth, Coleman, Dabheoc, Dalziel, Jack, Dykes, Joseph, Fine, Christopher, Gay, Bethan, Goddard, Wendy, Goodchild, Drew, Harling, Rhiannan, Hijazi, Muhammad, Keith, Sarah, Khan, Meherunnisa, Matt, Roseanna, Ryan-Smith, Janet, Saad, Samuel, Springle, Philippa, Thomas, Jacqueline, Truman, Nick, Kazi, Aayesha, Smith, Matthew, Collier, Heather, Davison, Chloe, Duberley, Stephen, Hargreaves, Jeanette, Hartley, Janice, Patel, Tahera, Smith, Ellen, Kent, Alissa, Goodwin, Emma, Zaki, Ahmed, Tibke, Clare, Hopkins, Susan, Gerrard, Hywel, Jackson, Matthew, Bennett, Sara, Marsh, Liane, Mills, Rebecca, Bell, Jessica, Campbell, Helen, Dawson, Angela, Dodds, Steve, Duffy, Stacey, Gallagher, Lisa, McCafferty, Gemma, Short, Stacey, Smith, Tracy, Thomas, Kirsty, Walker, Claire, Reynolds, Jessica, Yates, Bryan, McKie, Hayley, Panteli, Maria, Thompson, Maria, Waddell, Gail, Beger, Sarah De, Abraheem, Azmerelda, Dunmore, Charlie, Girach, Rumanah, Jones, Rhianna, London, Emily, Nagra, Imrun, Nasir, Farah, Sainsbury, Hannah, Smedley, Clare, Brearey, Stephen, Burchett, Caroline, Cawley, Kathryn, Faulkner, Maria, Jeffrey, Helen, Bamford, Peter, Shaikh, Firdaus, Slack, Lauren, Davies, Angela, Brooke, Hollie, Suarez, Jose Cebrian, Charlesworth, Ruth, Hansson, Karen, Norris, John, Poole, Alice, Sandhu, Rajdeep, Smithson, Elizabeth, Thirumaran, Muthu, Wagstaff, Veronica, Buckley, Sarah, Sloan, Brendan, Rose, Alastair, Major, Amy, Metcalfe, Alexandra, Almaden-Boyle, Christine, Austin, Pauline, Chapman, Susan, Eros, Alexandre, Cabrelli, Louise, Cole, Stephen, Whyte, Clare, Casey, Matt, Bafitis, Vasileios, Tsinaslanidis, George, George, Cassandra, Khade, Reena, Black, Christopher, Ashok, Sundar Raj, Farley, Sean, Brinkworth, Elaine, Harford, Rachel, Murphy, Carl, Williams, Marie, Newey, Luke, Toghill, Hannah, Lewis, Sophie, Rees, Tabitha, Battle, Ceri, Baker, Mark, Travers, Jenny, Chesters, Karen, Baxter, Nicola, Arnott, Andrew, McCreath, Gordan, McParland, Christopher, Rooney, Laura, Sim, Malcolm, Henderson, Steven, Abel, Lynn, Dalton, Carol, Kennedy-Hay, Sophie, O’Donohoe, Lynn, O’Hare, Megan, Orlikowska, Izabela, Parker, Natasha, McNeela, Fiona, Lyle, Amanda, Hughes, Alistair, Radhakrishnan, Jayachandran, Gibson, Sian, Bancroft, Hollie, Bellamy, Mary, Daglish, Jacqueline, Kadiri, Salma, Moore, Faye, Rhodes, Joanne, Sangombe, Mirriam, Peterkin, Zhane, Scriven, James, Carmody, Margaret, Cottle, Juliet, Peasgood, Emily, de Gordoa, Laura Ortiz-Ruiz, Phillips, Claire, Skinner, Denise, Cinquina, Zoe, Howard, Kate, Joy, Rosie, Roche, Samantha, Birkinshaw, Isobel, Carter, Joseph, Ingham, Jo, Marshall, Nicola, Pearson, Harriet, Scott, Zoe, Dasgin, Jo, Gill, Jaspret, Nilsson, Annette, Bamford, Amy, Hull, Diana, Ahmadhaider, Nafeesah, Bates, Michelle, McGhee, Christopher, Ellis, Hannah, Howe, Gwenllian Sera, Singh, Jayaprakash, Stroud, Natalie, Roche, Lisa, Lynch, Ceri, Deacon, Bethan, Pothecary, Carla, Smeaton, Justyna, Agravante, Kevin, Krishnamurthy, Vinodh, Diaba, Cynthia, John, Lincy, Lim, Lai, Jha, Rajeev, Egan, Jasmine, Felton, Timothy, Glasgow, Susannah, Padden, Grace, Choudhr, Ozerah, Bradley-Potts, Joanne, Moss, Stuart, Lingeswaran, Saejohn, Alexander, Peter, Brandwood, Craig, Fiouni, Sofia, Ward, Luke, Allen, Schvearn, Shaw, Jane, Smith, Christopher, Adanini, Oluronke, Collins, Rebecca, Msiska, Maines, Ofori, Linda, Bhatia, Nikhil, Dolan, Hayley, Brunton, Mark, Caterson, Jess, Coles, Holly, Keating, Liza, Tilney, Emma, Jacques, Nicola, Frise, Matthew, Armistead, Jennifer, Bartley, Shauna, Bhuie, Parminder, Rai, Sabi, Tomkova, Gabriela, Greer, Sandra, Shuker, Karen, Tridente, Ascanio, Dobson, Emma, Hunt, Jodie, Tully, Redmond, Dearden, Joy, Drummond, Andrew, Kamath, Prakash, Bullock, Emily, Mulcahy, Michelle, Munt, Shelia, O’Connor, Grainne, Philbin, Jennifer, Rishton, Chloe, Scott, Chloe, Winnard, Sarah, Hasni, Nurkamalia, Gascoyne, Rachel, Hawes, Joanne, Pritchard, Kelly, Stevenson, Lesley, Whileman, Amanda, Beavis, Sarah, Bishop, Lauren, Cart, Cindy, Dale, Katie, Kelly-Baxter, Mary, Mendelski, Adam, Moakes, Emma, Smith, Rheanna, Woodward, Jan, Wright, Stephanie, Allan, Angela, Botello, Adriana, Liew, Jade, Medhora, Jasmine, Trumper, Erin, Savage, Felicity, Scott, Teresa, Place, Marc, Kaye, Callum, Benyon, Sarah, Marriott, Suzie, Park, Linda, Quinn, Helen, Skyes, Daisy, Zitter, Lily, Baines, Kizzy, Gordon, Elizabeth, Keenan, Samantha, Pitt, Andrew, Duffy, Katharine, Ireland, Jane, Semple, Gary, Turner, Lynne, Cathcart, Susanne, Rimmer, Dominic, Puxty, Alex, Puxty, Kathryn, Hurst, Andrew, Miller, Jennifer, Speirs, Susan, Walker, Lauren, Bradshaw, Zena, Brown, Joanna, Melling, Sarah, Preston, Stephen, Slawson, Nicola, Warden, Scott, Beasley, Alanna, Stoddard, Emma, Benham, Leonie, Cupitt, Jason, Caswell, Melanie, Elawamy, Lisa, Wignall, Ashleigh, Roberts, Belinda, Golding, Hannah, Leggett, Samantha, Male, Michelle, Marani, Martyna, Prager, Kirsty, Williams, Toran, Golder, Kim, Jones, Oliver, Cusack, Rebecca, Bolger, Clare, Burnish, Rachel, Carter, Michael, Jackson, Susan, Salmon, Karen, Biss, Jonathan, Aquino, Maia, Croft, Maria, Frost, Victoria, White, Ian, Govender, Keshnie, Webb, Natasha, Stapleton, Liana, Wells, Colin, Nikitas, Nikitas, Sanchez - Rodriguez, Ana, Spencer, Kayleigh, Stowe, Bethan, Izzard, Yvonne, Poole, Michelle, Monnery, Sonja, Trotman, Sallyanne, Beech, Valerie, Combes, Edward, Joefield, Teishel, Covernton, Patrick, Savage, Sarah, Woodward, Elizabeth, Camsooksai, Julie, Reschreiter, Henrik, Barclay, Charlotte, DeAth, Yasmin, Dube, Judith, Humphrey, Charlotte, Jenkins, Sarah, Langridge, Emma, Milne, Rebecca, Wadams, Beverley, Woolcock, Megan, Brett, Michael, Digby, Brian, Gemmell, Lisa, Hornsby, James, MacGoey, Patrick, O’Neil, Pauline, Price, Richard, Sundaram, Radha, Rodden, Natalie, Thomson, Nicola, Rooney, Kevin, Currie, Susan, Henderson, Philip, Ogg, Bethan, Whiteley, Simon, Wilby, Liz, Long, Kate, Matthew, Shailamma, Salada, Sheila, Trott, Susan, Watts, Sarah, Friar, Zoe, Speight, Abigail, Bastion, Victoria, Chandna, Humza, Djeugam, Brice, Haseeb, Muhammad, Kent, Harriet, Lubimbi, Gamu, Murdoch, Sophie, Thomas, Alastair, David, Beena, Lorusso, Rachel, Vochin, Ana, Penacerrada, Melchizedek, Wulandari, Retno, Heath, Charlotte, Jakkula, Srinivas, Morris, Anna, Ahmed, Ashar, Nune, Arvind, Buttriss, Claire, Whitaker, Emma, Davey, Miriam, Golden, David, Acklery, Amy, Fernandes, Fabio, Seaman, Bec, Earl, Victoria, Collins, Amy, Khaliq, Waqas, Adam, Rachel, Treus, Estefania, Holland, Sarah, Alfonso, Jordan, Blackledge, Bethan, Bruce, Michelle, Durrans, Laura Jayne, Eltayeb, Ayaa, Harris, Jade, Hey, Samuel, Hruska, Martin, Lamb, Thomas, Rothwell, Joanne, Fitzgerald, Adele, Lindergard, Gabriella, T-Michael, Helen, Duncan, Tracey, Baxter-Dore, Sharon, Cooper, Lisa, Fox, Claire, Guerin, Jacinta, Hodgkiss, Tracey, Connolly, Karen, McAlinden, Paul, Bridgett, Victoria, Fearby, Maggie, Gulati, A., Hanson, Helen, Kelly, Sinead, McCormack, Louise, Nixon, Rachel, Robinson, Philip, Slater, Victoria, Stephenson, Elaine, Webster, Andrea, Webster, K., Hays, Carole, Hudson, Anne, Patel, Bijal, Clement, Ian, Davis, John, Francis, Sarah, Jerry, Douglas, Abernathy, Caroline, Foster, Louise, Gratrix, Andrew, Cabral-Ortega, Llucia, Hines, Matthew, Martinson, Victoria, Stones, Elizabeth, Winter, Karen, Barrow, Esther, Wylie, Katharine, Baines, Deborah, Birchall, Katie, Kolakaluri, Laurel, Clark, Richard, Sukumaran, Anila, Barker, Melanie, Paripoorani, Deborah, Smith, Lara, Taylor, Charlotte, Downes, Charlotte, Hayman, Melanie, Riches, Katie, Daniel, Priya, Subramanian, Deepak, Holding, Kathleen, Hilton, Mary, Mcdonald, Carly, Richardson, Georgina, Halladay, Georgia, Harding, Peter, Reddy, Amie, Turner-Bone, Ian, Wilding, Laura, Parker, Robert, Lloyd, Michaela, Smith, Leanne, Kelly, Charlie, Lazo, Maria, Neal, Alan, Walton, Olivia, Melville, Julie, Naisbitt, Jay, Joseph, Rosane, Callam, Sara, Hudig, Lisa, Keshet-Price, Jocelyn, Stammers, Katie, Convery, Karen, Randell, Georgina, Fottrell-gould, Deirdre, Mwaura, Esther, Sutherland, Sara-Beth, Stewart, Richard, Mew, Louise, Wren, Lynn, Thrasyvoulou, Laura, Willis, Heather, Hopkins, Bridget, Lenton, Daniel, Roberts, Abigail, Bokhari, Maria, Lucas, Rachael, McCormick, Wendy, Ritzema, Jenny, Linnett, Vanessa, Sanderson, Amanda, Wild, Helen, Flanagan, Rebecca, Hull, Robert, Rhead, Kat, McKenna, Emma, Hughes, Gareth, Anderson, Jennifer, Jones, Kelly, Latham, Scott, Riley, Heather, Coulding, Martina, Clark, Martyn, McCormick, Jacqueline, Mercer, Oliver, Potla, Darsh, Rehman, Hafiz, Savill, Heather, Turner, Victoria, Jude, Edward, Kilroy, Susan, Apetri, Elena, Basikolo, Cathrine, Catlow, Laura, Collis, Matthew, Doonan, Reece, Harvey, Alice, Knowles, Karen, Lee, Stephanie, Lomas, Diane, Lyons, Chloe, McMorrow, Liam, Michael, Angiy, Pendlebury, Jessica, Perez, Jane, Poulaka, Maria, Proudfoot, Nicola, Slevin, Kathryn, Thomas, Vicky, Walker, Danielle, Dark, Paul, Charles, Bethan, McLaughlan, Danielle, Slaughter, Melanie, Horner, Dan, Marsden, Tracy, Andrews, Joyann, Beech, Emily, Akinkugbe, Olugbenga, Bamford, Alasdair, Belfield, Holly, Jones, Gareth A. L., McHugh, Tara, Meghari, Hamza, Ray, Samiran, Tomas, Ana Luisa, O’Neill, Lauran, Peters, Mark, Bell, Michael, Benkenstein, Sarah, Chisholm, Catherine, Davies, Charlene, Kupiec, Klaudia, Payne, Caroline, Halls, Joanna, Blakemore, Hayley, Goff, Elizabeth, Hayes, Kati, Smith, Kerry, Stephens, Deanna, Worner, Ruth, Borislavova, Borislava, Faulkner, Beverley, Thomas, Matt, Cookson, Ruth, Gendall, Emma, Larman, Georgina, Pope, Rebecca, Smalira, Artur, Priestley, Victoria, Cosier, Tracey, Millen, Gemma, Rand, James, Schumacher, Natasha, Sandhar, Roxana, Weston, Heather, Richardson, Neil, Cooper, Lucy, Jones, Cathy, Huang, Ya-Wen Jessica, Jacob, Reni, Denmade, Craig, Mcintyre, Lewis, Trodd, Dawn, Martin, Jane, Watson, Geoff, Bevan, Emily, Wreybrown, Caroline, Bano, Shereen, Bellwood, Ruth, Bentley, Michael, Bromley, Matt, Gurr, Lucy, Ledgard, Camilla, McGowan, Janet, Pye, Kate, Sellick, Kirsten, Stacey, Amelia, Warren, Deborah, Wilkinson, Brian, Akeroyd, Louise, Shafique, Huma, Morgan, James, Shorter, Susan, Swinger, Rachel, Waters, Emily, Lawton, Tom, Allan, Elizabeth, Darlington, Kate, Davies, Ffyon, Davies, Llinos, Easton, Jack, Kumar, Sumit, Lean, Richard, Mackay, Callum, Pugh, Richard, Qiu, Xinyi, Rees, Stephanie, Scanlon, Jeremy, Lewis, Joanne, Menzies, Daniel, Bolger, Annette, Davies, Gwyneth, Davies, Jennifer, Garrod, Esther, Jones, Helen, Manley, Rachel, Williams, Hannah, Frankham, Jordan, Pitts, Sally, White, Nigel, Branney, Debbie, Tiller, Heather, Efford, Georgia, Garland, Zoe, Grimmer, Lisa, Gumbrill, Bethany, Johnson, Rebekah, Sweet, Katie, Bewley, Jeremy, Coleman, Christina, Corcoran, Katie, Morano, Eva Maria Hernandez, Shiel, Rachel, Webster, Denise, Bonnici, Josephine, Daniel, Eleanor, Dell, Abbie, Kent, Melanie, Wilkinson, Ami, Brown, Ellen, Kay, Andrea, Campbell, Suzanne, Cowton, Amanda, Birt, Mark, Greenaway, Vicki, Potts, Kathryn, Hutton, Clare, Shepperson, Andrew, Forsey, Miranda, Nicholson, Alice, Vertue, Mark, Riches, Joanne, Kaliappan, Agilan, Nicholson, Anne, MacCallum, Niall, Raith, Eamon, Bercades, Georgia, Hass, Ingrid, Brealey, David, Martir, Gladys, Reyes, Anna, Smyth, Deborah, Zapatamartinez, Maria, Alvaro, Ana, Jetha, Champa, Ma, Louise, Booker, Lauren, Mostoles, Loreta, Pratley, Anezka, Altabaibeh, Abdelhakim, Parmar, Chetan, Gilbert, Kayleigh, Ferguson, Susie, Shepherd, Amy, Morris, Sheila, Baruah, Rosie, Lloyd, Georgina, Bell, Stephanie, Rivers, Vanessa, Purewal, Bally, Hammerton, Kate, Anderson, Susan, Birch, Janine, Collins, Emma, Oleary, Ryan, Cornell, Sarah, Jarmain, Jordan, Rogerson, Kimberley, Wakinshaw, Fiona, Woods, Lindsey, Rostron, Anthony, Elcioglu, Zeynep, Roy, Alistair, Bell, Gillian, Dickson, Holly, Wilcox, Louise, Katary, Amro, English, Katy, Hutter, Joanne, Pawley, Corinne, Doble, Patricia, Shovelton, Charmaine, Vaida, Marius, Purnell, Rebecca, Thomas, Ashly, Cagova, Lenka, Fofano, Adama, Holcombe, Helen, Mitchell, Alice Michael, Mwaura, Lucy, Praman, KrithivasanÂ, Garnr, Lucie, Mepham, Sue, Paques, Kitty, Vuylsteke, Alain, Mackie, Jennifer, Pearn, Carmen, Zamikula, Julie, Nyirenda, Maggie, Capozzi, Lisa, Reece-Anthony, Rosie, Noor, Hazma, Nilo, Alfa Cresia, Grove, Michelle, Daniel, Amelia, Finn, Joanne, White, Nikki, Saha, Rajnish, Badal, Bibi, Ixer, Karen, Duffin, Donna, Player, Ben, Hill, Helen, Cole, Jade, Brooks, Jenny, Davies, Rhys, Hunt, Lauren, Thomas, Emma, Williams, Angharad, Oblak, Metod, Thankachen, Mini, Irisari, Jamie, Sayan, Amrinder, Popescu, Monica, Finch, Cheryl, Jamieson, Andrew, Quinn, Alison, Cooper, Joshua, Liderth, Sarah, Waddington, Natalia, Burn, Iona, Manso, Katarina, Penn, Ruth, Tebbutt, Julie, Thornton, Danielle, Winchester, James, Hambrook, Geraldine, Shanmugasundaram, Pradeep, Craig, Jayne, Simpson, Kerry, Higham, Andrew, Sibbett, Louise, Paine, Sheila, Reed, Annabel, Conyngham, Jo-Anna, Mupudzi, Mcdonald, Thomas, Rachel, Wright, Mary, Griffin, Denise, Partridge, Richard, Corral, Maria Alvarez, Muchenje, Nycola, Sitonik, Mildred, Butler, Aaron, Folkes, Linda, Fox, Heather, Gardner, Amy, Helm, David, Hobden, Gillian, King, Kirsten, Margalef, Jordi, Margarson, Michael, Martindale, Tim, Meadows, Emma, Raynard, Dana, Thirlwall, Yvette, Baird, Yolanda, Gomez, Raquel, Martin, Darren, Hodgson, Luke, Corin, Clinton, Sidall, Erikka, Szabo, Densie, Floyd, Sharon, Davies, Hannah, Austin, Karen, Kelsall, Olivia, Wood, Hannah, Cornell, Thomas, Ralph, Kate, Bean, Sarah, Burt, Karen, Spivey, Michael, Richards, Carol, Tedstone, Rachel, Carmody, Siobhain, Zhao, Xiaobei, Page, Valerie, Guanco, Mark Louie, Hoxha, Elvira, Zorloni, Camilla, Dean, Charlotte, Jones, Emma, Carter, Emma, Dunn, Joshua, Kong, Thomas, Mahenthran, Mervin, Marsh, Chris, Holland, Maureen, Keenan, Natalie, Mahmoud, Mohamed, Lyons, Marc, Wassall, Helen, Young, Meghan, Bradley, Paul, Burda, Dorota, Donlon, Sinead, Harden, Lesley, Harris, Celia, Mayangao, Irving, Montaser, Rugia, Mtuwa, Sheila, Piercy, Charles, Smith, Eleanor, Stone, Sarah, Verula, Jerik, Blackman, Helen, Marriott, Cheryl, Michalak, Natalia, Creagh-Brown, Ben, Salberg, Armorel, Boyer, Naomi, Pristopan, Veronika, Maynard, Victoria, Walker, Rachel, Hormis, Anil, Collier, Dawn, Graham, Cheryl, McCormick, Jake, Warrington, Jake, Cosgrove, Denise, McFarland, Denise, Ratcliffe, Judith, Charnock, Rob, Wynter, Inez, Gill, Mandy, Kirk, Jill, Paul, Paul, Ratnam, Valli, Shelton, Sarah, Jardine, Catherine, Hay, Alasdair, Williams, Dewi, Durga, Latha, Hibbert, Meg, Kennard-Holden, Gareth, Woodford, Chrsitopher, Tetla, Dariusz, Price, Alicia, Thomas, Alice, Thorpe, Chris, Knights, Ellen, Ward, Donna, Laha, Shondipon, Verlander, Mark, Williams, Alexandra, Prout, Rachel, Langton, Helen, Watters, Malcolm, Hunt, Charlotte, Novis, Catherine, Arif, Sarwat, Cunningham, Amy, Hewitt, Claire, Hindale, Julia, Jackson-Lawrence, Karen, Shepardson, Sarah, Wills, Maryanne, Butler, Susie, Tavares, Silivia, Barber, Russell, Hilldrith, Annette, Hubbard, Kelly, Egginton, Dawn, Clark, Michele, Purvis, Sarah, Sinclair, Simon, Collins, Vicky, Landeg, Bethan, Sell, Craig, Coetzee, Samantha, Gales, Alistair, Otahal, Igor, Icke, Becky, Raj, Meena, Williams, Caroline, Williams, Jill, Hill, Lucy, Kayani, Abdul, Masunda, Bridgett, Gondo, Prisca, Atayeva, Nigara, Cruz, Carina, Pattison, Natalie, Burnett, Caroline, Hatton, Jonathan, Heeney, Elaine, Newton, Maria, Al-Moasseb, Hassan, Behan, Teresa, Player, Jasmine, Stead, Rachael, Mitra, Atideb, Nauyokas, Kirsty, Humphreys, Sally, Cockerill, Helen, Tampsett, Ruth, Postovalova, Evgeniya, Coventry, Tina, McGregor, Amanda, Fowler, Susan, Macmahon, Mike, Cochrane, Patricia, Pirie, Sandra, Hanley, Sarah, Ali, Asifa, Brady, Megan, Dale, Sam, Dance, Annalisa, Gledhill, Lisa, Greig, Jill, Hanson, Kathryn, Holdroyd, Kelly, Home, Marie, Ishaq, Tahira, Kelly, Diane, Matapure, Lear, Melia, Deborah, Mellor, Samantha, Merwaha, Ekta, Nortcliffe, Tonicha, Shaw, Lisa, Shaw, Ryan, Wood, Tracy, Bayo, Lee-Ann, Usher, Miranda, Wilson, Alison, Kitson, Ross, Pinnell, Jez, Robinson, Matthew, Boltwood, Kaitlin, Birch, Jenny, Bough, Laura, Tutton, Rebecca, Winter-Goodwin, Barbara, Goodsell, Josie, Taylor, Kate, Williams, Patricia, Williams, Sarah, Cave, Ashleigh, Rees, James, Imeson-Wood, Janet, Smith, Jacqueline, Amin, Vishal, Karthik, Komala, Kausar, Rizwana, Anastasescu, Elena, Reid, Karen, Anumakonda, Vikram, Stoddart, Ella, Demetriou, Carrie, Eckbad, Charlotte, Howie, Lucy, Mitchard, Sarah, Ramos, Lidia, White, Katie, Hierons, Sarah, Kelly, Fiona, Serrano-Ruiz, Alfredo, Evans, Gabrielle, Nicol, Liz, Wilkins, Joy, Hulacka, Kim, Debreceni, Gabor, Brown, Alison, Crickmore, Vikki, Hill, Kay, Kannan, Thogulava, Dagutao, Zenaida, Beesley, Kate, Lewis, Alison, Perry, Jess, Antony, Sherly, Board, Sarah, Buckley, Clare, Pippard, Lucy, Tanate, Alfonso, Wood, Diane, Kubisz-Pudelko, Agnieska, Gouda, Ayman, Auld, Fiona, Donnachie, Joanne, Murdoch, Euan, Prentice, Lynn, Runciman, Nikole, Senaratne, Dhaneesha, Short, Abigail, Sweeney, Laura, Symon, Lesley, Todd, Anne, Turner, Patricia, McCann, Erin, Salutous, Dario, Edmond, Ian, Whitelaw, Lesley, Bland, Yvonne, Kajtor, Istvan, Kavanagh, Lisa, Singler, Karen, Linfield-Brown, George, Moore, Luke Stephen Prockter, Vizcaychipi, Marcela, Martins, Laura, Moore, Luke, Bull, Rhian, Carungcong, Jaime, Allen, Louise, Beranova, Eva, Knight, Alicia, Price, Carly, Tilbey, Sorrell, Turney, Sharon, Hazelton, Tracy, Tutt, Gabriella, Arora, Mansi, Turki, Salah, Sinfield, Emily, Deery, Joanne, Ramos, Hazel, Cristiano, Daniele, Dormand, Natalie, Farzad, Zohreh, Gummadi, Mahitha, Salmi, Sara, Sloane, Geraldine, Varghese, Mathew, Thwaites, Vicky, Patel, Brijesh, Kamal, Liyanage, Zborowski, Anelise Catelan, Coe, Ryan, Anderson, Madeleine, Beadle, Jane, Coates, Charlotte, Collins, Katy, Crowley, Maria, Johnson, Laura, King, Laura, Paramsothy, Remi, Sargeant, Janet, Silva, Pedro, Stuart, Carmel, Taylor, June, Tyl, David, Wakefield, Phillipa, Kamundi, Charlotte, Olufuwa, Olumide, Belagodu, Zakaulla, Gherman, Anca, Oakley, Naomi, Allan, John, Geary, Tim, Meikle, Alistair, O’Brien, Peter, Wood, Stephen, Clark, Andrew, Houston, Gordon, Black, Karen, Clarkson, Michelle, D’Sylva, Stuart, Morrison, Alan, Norman, Kathryn, Taylor, Margaret, Clements, Suzanne, Cohrane, Catriona, Gonzalez, Nora, Strachan, Dominic, Beith, Claire, Moar, Kirsten, Anderson, Peter, Archer, Katie, Burtenshaw, Andrew, Clayton, Sarah, Cother, Naiara, Cowley, Nicholas, Davis, Caroline, Digby, Stephen, Durie, Alison, Harrison, Alison, Low, Emma, McAlindon, Michael, McCurdy, Alex, Morgan, Aled, Rankin, Tobias, Thrush, Jessica, Tranter, Helen, Vigurs, Charlie, Wild, Laura, Murphy, Lorna, Smythe, Michelle, Brickell, Kathy, Ali, Inthakab Ali Mohamed, Beaumont, Karen, Elsaadany, Mohamed, Fernandes, Kay, Ally, Sameena Mohamed, Rangarajan, Harini, Sarathy, Varun, Selvanayagam, Sivarupan, Vedage, Dave, White, Matthew, Coton, Zoe, Joshy, Aricsa, Blunt, Mark, Curgenven, Hollie, Botfield, Liam, Dexter, Catherine, Kuravi, Aditya, Butler, Joanne, Chadwick, Robert, Ranga, Poonam, Richardson, Lisa, Virgilio, Emma, Anwer, Maddiha, Garg, Atul, Botfield, Donna, Marriott, Xana, Stewart, Keely, Mullan, Dee, Gaylard, Jane, Nowak, Justyna, Jones, Sian, Crawley, Rikki, Crew, Abigail, Cunningham, Mishell, Daniels, Allison, Harrison, Laura, Hope, Susan, Lancaster, Nicola, Matthews, Jamie, Wray, Gemma, Inweregbu, Ken, Cutts, Sarah, Miller, Katharine, Brady, Ailbhe, Chan, Rebekah, McIvor, Shane, Prady, Helena, Mathew, Bijoy, Little, Jeff, Furniss, Tim, Wright, Chris, King, Bernadette, Wasson, Christopher, O’Neill, Aisling, Turley, Christine, McGuigan, Peter, Collins, Erin, Finn, Stephanie, Green, Jackie, McAuley, Julie, Nair, Abitha, Quinn, Charlotte, Tauro, Suzanne, Ward, Kathryn, McGinlay, Michael, Reddy, Kiran, Ahmad, Norfaizan, Anderson, Samantha, Barker, Joann, Bauchmuller, Kris, Birchall, Kathryn, Bird, Sarah, Cawthron, Kay, Chetam, Luke, Cole, Joby, Donne, Ben, Foote, David, Ford, Amber, Hanratty, Helena, Harrington, Kate, Hesseldon, Lisa, Housley, Kay, Jackson, Yvonne, Jarman, Claire, Kibutu, Faith, Lenagh, Becky, Macharia, Irene, Masuko, Shamiso, Milner, Leanne, Newell, Helen, Nwafor, Lorenza, Oxspring, Simon, Phillips, Patrick, Raithatha, Ajay, Rowland-Jones, Sarah, Smith, Jacqui, Thompson, Roger, Trower, Helen, Walker, Sara, Watson, James, Wiles, Matthew, Lye, Alison, Willson, Jayne, Mills, Gary, Harris, Sansha, Hartill, Eleanor, Barron, Anthony, Collins, Ciara, Kaul, Sundeep, Nolan, Claire, Polgar, Oliver, Prendergast, Claire, Rogers, Paula, Shokkar, Rajvinder, Woodruff, Meriel, Mahay, Kanta, Reed, Anna, Meyrick, Hayley, Passmore, Heather, Farwell, James, O’Connell, Susan, Gregory, Jane, Barberis, Luigi, Harper, Rosemary, Smith, Tim, Armstrong, Diane, Bowey, Angie, Cowley, Anne, Corner, Andrew, Highgate, Judith, Rutherfurd, Claire, Taylor, Jo-Anne, Goodwin, Sarah, Eapen, Beena, Trim, Fiona, Donnison, Phil, Armstrong, Lisa, Bates, Hayley, Dooks, Emma, Farquhar, Fiona, Kitching, Amy, McParland, Chantal, Packham, Sophie, Hairsine, Brigid, Andreou, Premetie, Hales, Dawn, Mathews, Megha, Patel, Rekha, Barry, Peter, Flint, Neil, Hailstone, Jessica, Ghuman, Navneet, Leonard, Bethany, Lees, Rachel, Butcher, Deborah, Leng, Katy, Butterworth-Cowin, Nicola, O’Sullivan, Susie, Ghosh, Alison, Williams, Emma, Adams, Colene, Agasou, Anita, Arden, Tracie, Beekes, Mandy, Bowes, Amy, Boyle, Pauline, Button, Heather, Carnahan, Mandy, Carter, Anne, Childs, Danielle, Hurford, Fran, Hussain, Yasmin, Javaid, Ayesha, Jones, James, Leigh, Michael, Martin, Terry, Millward, Helen, Motherwell, Nichola, Newman, Julie, Rikunenko, Rachel, Stickley, Jo, Summers, Julie, Ting, Louise, Tivenan, Helen, Donaldson, Denise, Capps, Nigel, Cale, Emily, Jose, Sanal, Osbourne, Wendy, Pajak, Susie, Rankin, Jayne, Tonks, Louise, Baird, Tracy, Harkins, Margaret, Ruddy, Jim, West, Joe, Duffield, Joseph, Mallon, Lewis, Smith, Oliver, Smuts, Sara, Campbell, Andy, Davies, Cate, Davies, Sarah, Hughes, Rachel, Jobes, Lisa, Whitehead, Victoria, Watkins, Clare, Bowman, Fiona, Milligan, Barry, McPherson, Liane, Metherell, Stella, Harris, Nichola, Lake, Victoria, Radford, Elizabeth, Smallwood, Andy, Gopal, Shameer, Vassell, Katherine, Bell, Dina, Boyle, Rosalind, Douglas, Katie, Glass, Lynn, Lennon, Liz, Rattray, Austin, Lee, Emma, Jones, Danielle, Parsons, Penny, Attwood, Ben, Jefferson, Paul, Ranganathan, Mohan, Atwal, Inderjit, Campbell, Bridget, Day, Angela, Stagg, Camilla, Haynes, Emma, Ahmed, Cecilia, Clamp, Sarah, Colley, Julie, Haq, Risna, Hayes, Anne, Joseph, Sibet, Maqsood, Zahira, Hussain, Samia, Hulme, Jonathan, Domingos, Patience, Kumar, Rita, Purewal, Manjit, Taylor, Becky, Bunni, Lara, Latif, Monica, Jennings, Claire, Jose, Shilu, Marshall, Rebecca, Metryka, Aleksandra, Subramanian, Gayathri, Burgoyne, Adam, Tyler, Amanda, Waldron, Joanne, Hilltout, Paula, Evitts, Jayne, Ward, Geraldine, Bremmer, Pamela, Hawkins, Carl, Jackman, Sophie, Ogorek, Michal, Ashby, Kylie, Thornton, Lorraine, Mercer, Pauline, Halkes, Matthew, Revill, Adam, Saint, Bryony, Fletcher, Jo, Netherton, Kimberley, Chablani, Manish, Kirkby, Amy, Roper, Amanda, Szymiczek, Kinga, Sutherland, Isobel, O’Brien, Linda, Connell, Joanne, Davies, Kim, Lewis, Tracy, Omar, Zohra, Perkins, Emma, Sathe, Sonia, Davies, Ellie, Lyon, Alex, Mapfunde, Isheunesu, Willis, Charlotte, Hitchcock, Rachael, Hall, Kathryn, King, Christopher, Fagan, Andrew, Nazari, Roonak, Worsley, Lucy, Allibone, Suzanne, Kasipandian, Vidya, Patel, Amit, Cutting, Parisa, Genetu, Roman, Mac, Ainhi, Murphy, Anthony, Ward, Sinead, Butt, Fatima, Ayers, Amanda, Harrison, Wendy, Mackintosh, Katherine, North, Julie, Ashton, Lydia, Bi, Rehana, Owen, Samantha, Winmill, Helen, Scholefield, Barney, Blowing, Hannah, Williams, Erin, Duskova, Michaela, Edwards, Michelle, Rees, Alun, Thomas, Helen, Brooks, Jolene, Phipps, Janet, Brooks, Suzanne, Dennis, Catherine, Parris, Vicki, Srikaran, Sinduya, Sukha, Anisha, McGregor, Alistair, Tiongson, Gerlynn, Adams, Katie, Andrew, Benedict, Brayne, Adam, Carter, Sasha, Findlay, Louise, Fisher, Emma, Jackson, Peter, Kaye, Duncan, Parkin, Juliet, Tuckey, Victoria, Hunt, Jane, Love, Nicholas, van Koutrick, Lynne, Hanson, Ashley, Dent, Kathy, Horsley, Elizabeth, Pearson, Sandra, Spencer, Sue, Hutchinson, Dorothy, Potoczna, Dorota, Akhtar, Muhammad Nauman, Cottam, Lisa-Jayne, Sanders, Jack, Garcia, Sara Mingo, pakou, Glykeria, Filipe, Helder, Maharajh, Amitaa, de Neef, Mark, Martin, Daniel, Eastgate, Christine, Teoh, Poh Choo, Barrett, Fiona, Bradley, Clare, Donaldson, Avril, Mascarenhas, Mairi, O’Hara, Marianne, Okeefe, Laura, Clarke, Noreen, Whiteside, Jonathan, Campbell, Rachael, Matheson, Joanna, McDonald, Deborah, Patience, Donna, Rice, Polly, Clapham, Melanie, Mutch, Rachel, Craig, Hannah, Poultney, Una, Burns, Karen, Twiss, Sophie, Barton, Janet, George, Linsha, Harrop, Clare, Mathew, Sherly, Wright, David Justin, Harrison, Rachel, Toohie, Jordan, Chandler, Ben, Turnbull, Alison, Mallinson, Janine, Elliott, Kerry, Wolf-Roberts, Rebecca, Tench, Helen, Hobrok, Maria, Loosley, Ronda, McGuinness, Heather, Sims, Tanya, Afolabi, Deborah, Allison, Kathryn Sian, Anderson, Taya, Dore, Rachael, Jones, Dawn, Rogers, Naomi, Saunderson, Paula, Whitbread, Jennifer, O’Malley, Laura, Rad, Laura, Hawcutt, Daniel, Aldridge, Jonathan, Tolson, Melanie, Garrioch, Sweyn, Tomlinson, Joanne, Grosdenier, Michael, Loader, David, Kapoor, Ritoo, Hector, Gemma, Scherewode, Joslan, Sri-Chandana, Chunda, Stephenson, Lorraine, Marsh, Sarah, Rosa, Arnold Dela, Jhanji, Shaman, Bemand, Thomas, Howle, Ryan, Baikady, Ravishankar Rao, Thomas, Benjamin, Black, Ethel, Tatham, Kate, Gurram, Sambasivarao, Watson, Ekaterina, Quaid, Sheena, Saunderson, Anne, O’Brien, Rachel, Moultrie, Sam, Service, Jen, Cheyne, Clare, Odam, Miranda, Wiliams, Alison, Barnes, Nicky, Csabi, Peter, Rocha, Joana Da, Glynou, Louika, Huffenberger, Amy, Bryant, Jade, Pickard, Amy, Roe, Nicholas, Bellini, Arianna, Mayer, Anton, Burrow, Amy, Colley, Natalie, Evans, Jayne, Howlett, Alex, Khalifeh, Zeinab, Pryce, Jerldine, Gorman, Claire, Brady, Rebecca, Timlick, Elizabeth, Antoine, Pierre, Gupta, Abhinhav, Hardy, John, Houlden, Henry, Moncur, Eleanor, Tucci, Arianna, Tariq, Ambreen, Tagliavini, Emma, Ramsay, Becky, Fidler, Katy, Donnelly, Kevin, Hollis, Rebecca, Barr, Jocelyn, Boyd, Elizabeth, Irvine, Val, Shelley, Ben, Buckley, Julie, Hamilton, Charlene, Valdeavella, Kathryn, Bircham, Sarah, Liggett, Steven, Patil, Anand, Siddiq, Afshan, Goddard, Peter, Donovan, Sally, Zainy, Tala, Maleady-Crowe, Fiona, Todd, Linda, Salehi, Shahla, Elgar, Greg, Chan, Georgia, Arumugam, Prabhu, Patch, Christine, Rendon, Augusto, Bentley, David, Kingsley, Clare, Fowler, Tom A., Elliott, Paul, Tenesa, Albert, Aitkin, Emma, Aravindan, Latha, Armstrong, Ruth, Biggs, Heather, Boz, Ceilia, Brown, Adam, Chikowore, Primmy, Coutts, Audrey, Coyle, Judy, Cullum, Louise, Das, Sukamal, Day, Nicky, Donnelly, Lorna, Duncan, Esther, Finernan, Paul, Fourman, Max Head, Furlong, Anita, Furniss, James, Gallagher, Bernadette, Gilchrist, Tammy, Golightly, Ailsa, Hafezi, Katarzyna, Hamilton, Debbie, Hendry, Ross, Kearns, Naomi, Law, Dawn, Law, Rachel, Law, Sarah, Lidstone-Scott, Rebecca, Lauder, Christen, Macgillivray, Louise, Maclean, Alan, Mal, Hanning, McCafferty, Sarah, Mcmaster, Ellie, Meikle, Jen, Moore, Shona C., Murphy, Sheena, Mybaya, Hellen, Oosthuyzen, Wilna, Zheng, Chenqing, Chen, Jiantao, Paterson, Trevor, Tucker, Petra, Schon, Katherine, Stenhouse, Andrew, Das, Mihaela, Swets, Maaike, Szoor-McElhinney, Helen, Taneski, Filip, Turtle, Lance, Wackett, Tony, Ward, Mairi, Weaver, Jane, Wrobel, Nicola, Rakitko, Alexander, Ilinsky, Valery, Yermakovich, Danat, Popov, Iaroslav, Chernitsov, Alexander, Kovalenko, Elena, Vergasova, Ekaterina, Prokhorov, Alexandr, Krasnenko, Anna, Plotnikov, Nikolay, Stetsenko, Ivan, Kim, Anna, Cirulli, Elizabeth T., Schiabor Barrett, Kelly M., Bolze, Alexandre, White, Simon, Washington, Nicole L., Lu, James T., Riffle, Stephen, Tanudjaja, Francisco, Wang, Xueqing, Ramirez, Jimmy M., Leonetti, Nicole, Sandoval, Efren, Neveux, Iva, Dabe, Shaun, Grzymski, Joseph J., Joshi, Madhvi N., Dixit, Raghav D., Shah, Pranay K., Upadhyay, Kamlesh J., Chuhan, Naresh T., Desai, Kairavi J., Shah, Meenakshi R., Modi, Bhavesh, Joshi, Chaitanya G., Pandit, Ramesh J., Singh, Indra, Ansari, Afzal I., Raval, Janvi N., Patel, Zarna Z., Moreno-Estrada, Andres, Vázquez-Pérez, Joel Armando, Castillejos-López, Manuel, Aquino-Gálvez, Arnoldo, Shamah-Levy, Teresa, Ávila-Arcos, María C., Luna, María Teresa Tusié, Hidalgo-Miranda, Alfredo, Barberena-Jonas, Carmina, Quinto-Cortés, Consuelo D., Ávila-Arcos, Marco Antonio, Huerta-Chagoya, Alicia, García-García, Lourdes, Barnetche, Jesús Martinez, Alpuche-Aranda, Celia, Rivera, Juan A., Gutiérrez, Tonatiuh Barrientos, Ochoa-Guzmán, Ana, Ordoñez-Sánchez, Maria Luisa, Segura-Kato, Yayoi, Herrera-Montalvo, Luis Alonso, Mendoza-Vargas, Alfredo, Reyes-Grajeda, Juan Pablo, Cruz-Cruz, Alonso D., Velázquez-Cruz, Rafael, Torres-Espíndola, Luz María, Sierra-Vargas, Martha Patricia, Camarena, Angel, Ruiz, Víctor, Chávez-Alderete, Jaime, Jaime-Capetillo, María Esther, Guadarrama-Pérez, Cristóbal, Zúñiga-Ramos, Joaquin, Olivera-Ramírez, Alejandra, Martínez, Miguel Angel López, Serna-Muñoz, Ricardo, Garmendia, Adriana, Namkoong, Ho, Okada, Yukinori, Imoto, Seiya, Katayama, Kazuhiko, Fukunaga, Koichi, Kitagawa, Yuko, Sato, Toshiro, Hasegawa, Naoki, Kumanogoh, Atsushi, Kimura, Akinori, Ai, Masumi, Tokunaga, Katsushi, Kanai, Takanori, Miyano, Satoru, Ogawa, Seishi, Edahiro, Ryuya, Sonehara, Kyuto, Shirai, Yuya, Ishii, Makoto, Kabata, Hiroki, Masaki, Katsunori, Kamata, Hirofumi, Ikemura, Shinnosuke, Chubachi, Shotaro, Okamori, Satoshi, Terai, Hideki, Tanaka, Hiromu, Morita, Atsuho, Lee, Ho, Asakura, Takanori, Sasaki, Junichi, Morisaki, Hiroshi, Uwamino, Yoshifumi, Nanki, Kosaku, Mikami, Yohei, Tomono, Kazunori, Kato, Kazuto, Matsuda, Fumihiko, Takahashi, Meiko, Hizawa, Nobuyuki, Takeda, Yoshito, Hirata, Haruhiko, Shiroyama, Takayuki, Miyawaki, Satoru, Suzuki, Ken, Maeda, Yuichi, Nii, Takuro, Noda, Yoshimi, Niitsu, Takayuki, Adachi, Yuichi, Enomoto, Takatoshi, Amiya, Saori, Hara, Reina, Takahashi, Kunihiko, Anzai, Tatsuhiko, Hasegawa, Takanori, Ito, Satoshi, Koike, Ryuji, Endo, Akifumi, Uchimura, Yuji, Miyazaki, Yasunari, Honda, Takayuki, Tateishi, Tomoya, Tohda, Shuji, Ichimura, Naoya, Sonobe, Kazunari, Sassa, Chihiro, Nakajima, Jun, Nannya, Yasuhito, Omae, Yosuke, Takahashi, Kazuhisa, Harada, Norihiro, Hiki, Makoto, Takagi, Haruhi, Nakamura, Ai, Tagaya, Etsuko, Kawana, Masatoshi, Arimura, Ken, Ishiguro, Takashi, Takayanagi, Noboru, Isono, Taisuke, Takaku, Yotaro, Takano, Kenji, Anan, Ryusuke, Nakajima, Yukiko, Nakano, Yasushi, Nishio, Kazumi, Ueda, Soichiro, Hayashi, Reina, Tateno, Hiroki, Hase, Isano, Yoshida, Shuichi, Suzuki, Shoji, Mitamura, Keiko, Saito, Fumitake, Ueda, Tetsuya, Azuma, Masanori, Nagasaki, Tadao, Yasui, Yoshinori, Hasegawa, Yoshinori, Mutoh, Yoshikazu, Yoshiyama, Takashi, Shoko, Tomohisa, Kojima, Mitsuaki, Adachi, Tomohiro, Ishikawa, Motonao, Takahashi, Kenichiro, Watanabe, Kazuyoshi, Manabe, Tadashi, Ito, Fumimaro, Fukui, Takahiro, Funatsu, Yohei, Koh, Hidefumi, Hirai, Yoshihiro, Kawashima, Hidetoshi, Narita, Atsuya, Niwa, Kazuki, Sekikawa, Yoshiyuki, Saito, Fukuki, Yoshiya, Kazuhisa, Yoshihara, Tomoyuki, Suzuki, Yusuke, Nakayama, Sohei, Masuzawa, Keita, Nishi, Koichi, Nishitsuji, Masaru, Tani, Maiko, Inoue, Takashi, Hirano, Toshiyuki, Kobayashi, Keigo, Miyazawa, Naoki, Kimura, Yasuhiro, Sado, Reiko, Ogura, Takashi, Kitamura, Hideya, Murohashi, Kota, Nakachi, Ichiro, Baba, Rie, Arai, Daisuke, Fuke, Satoshi, Saito, Hiroshi, Kuwahara, Naota, Fujiwara, Akiko, Okada, Takenori, Baba, Tomoya, Noda, Junya, Mashimo, Shuko, Yagi, Kazuma, Shiomi, Tetsuya, Hashiguchi, Mizuha, Odani, Toshio, Mochimaru, Takao, Oyamada, Yoshitaka, Mori, Nobuaki, Izumi, Namiki, Nagata, Kaoru, Taki, Reiko, Murakami, Koji, Yamada, Mitsuhiro, Sugiura, Hisatoshi, Hayashi, Kentaro, Shimizu, Tetsuo, Gon, Yasuhiro, Fujitani, Shigeki, Tsuchida, Tomoya, Yoshida, Toru, Kagaya, Takashi, Kita, Toshiyuki, Sakagami, Satoru, Kimizuka, Yoshifumi, Kawana, Akihiko, Nakamura, Yoshihiko, Ishikura, Hiroyasu, Takata, Tohru, Kikuchi, Takahide, Taniyama, Daisuke, Nakamura, Morio, Kodama, Nobuhiro, Kaneyama, Yasunari, Maeda, Shunsuke, Nagasaki, Yoji, Okamoto, Masaki, Ishihara, Sayoko, Ito, Akihiro, Chihara, Yusuke, Takeuchi, Mayumi, Onoi, Keisuke, Hashimoto, Naozumi, Wakahara, Keiko, Ando, Akira, Masuda, Makoto, Wakabayashi, Aya, Watanabe, Hiroki, Sageshima, Hisako, Nakada, Taka-Aki, Abe, Ryuzo, Shimada, Tadanaga, Kawamura, Kodai, Ichikado, Kazuya, Nishiyama, Kenta, Yamasaki, Masaki, Hashimoto, Satoru, Kusaka, Yu, Ohba, Takehiko, Isogai, Susumu, Takada, Minoru, Kanda, Hidenori, Komase, Yuko, Sano, Fumiaki, Asano, Koichiro, Oguma, Tsuyoshi, Harada, Masahiro, Takahashi, Takeshi, Shibusawa, Takayuki, Abe, Shinji, Kono, Yuta, Togashi, Yuki, Izumo, Takehiro, Inomata, Minoru, Awano, Nobuyasu, Ogawa, Shinichi, Ogata, Tomouki, Ishihara, Shoichiro, Kanehiro, Arihiko, Ozaki, Shinji, Fuchimoto, Yasuko, Kitagawa, Yuichiro, Yoshida, Shozo, Ogura, Shinji, Nishiyama, Kei, Yoshida, Kousuke, Beppu, Satoru, Fukuyama, Satoru, Eriguchi, Yoshihiro, Yonekawa, Akiko, Inoue, Yoshiaki, Yamagata, Kunihiro, Chiba, Shigeru, Narumoto, Osamu, Nagai, Hideaki, Ooshima, Nobuharu, Motegi, Mitsuru, Sagara, Hironori, Tanaka, Akihiko, Ohta, Shin, Shibata, Yoko, Tanino, Yoshinori, Sato, Yuki, Yamada, Yuichiro, Hashino, Takuya, Shinoki, Masato, Iwagoe, Hajime, Imamura, Tomonori, Umeda, Akira, Shimada, Hisato, Endo, Mayu, Hayashi, Shinichi, Takahashi, Mai, Nakano, Shigefumi, Yatomi, Masakiyo, Maeno, Toshitaka, Ishii, Tomoo, Utsugi, Mitsuyoshi, Ono, Akihiro, Kanaoka, Kensuke, Ihara, Shoichi, Komuta, Kiyoshi, Nishida, Nao, Kawai, Yosuke, Sugiyama, Masaya, Alawneh, Laith M., Maswadeh, Kinda B., Alsoub, Fatima S., AlRawashdeh, Tala J., Esawi, Ezaldeen, Abu Alragheb, Bayan O., Maswadeh, Ahmad B., Al-Kadash, Abdulfattah, Al-Ani, Abdallah, Alsafadi, Dana B., Shahin, Mohammad A., Qtaish, Nuseibah Al, Alawneh, Fade M., Abulail, Joseph A., Zhlawi, Hadi J., Alhousani, Tasneem N., Alzuraiqi, Mohammad R., Al-Ja’afreh, Mohammad M., Allouzy, Sara K., ALjalamdeh, Mothafer, Mansour, Tareq M., Alamer, Lina M., Issa, Ali Banni, Bani younis, Fatima M., Hawari, Feras I., Hayajneh, Wail A., Obeidat, Nathir M., Ahram, Mamoun, Zhlawi, Moh’d Wahib J., Alshaer, Walhan, Al-Kasasbeh, Malak M., Naffa, Randa G., Ismail, Mohammad A., Abdullah, Mohammed S., Ismail, Said I., Obeidat, Ma’en, Hernández Cordero, Ana I., Sin, Don D., Bossé, Yohan, Joubert, Philippe, Hao, Ke, Nickle, David, Timens, Wim, van den Berge, Maarten, Feng, Yen-Chen Anne, Mercader, Josep, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Green, Robert C., Mandla, Ravi, Schroeder, Philip, Perez, Emma F., Lee, Seung Hyuk T., Flores-Silva, Fernando Daniel, Chiquete, Erwin, Cantú-Brito, Carlos, Sifuentes-Osornio, José, de León-Garduño, Alfredo Ponce, Román-Montes, Carla Marina, Chávez-Manzanera, Emma, Velasco, Donaji Gómez, Martagón-Rosado, Alexandro, Cruz-Bautista, Ivette, Gómez-Pérez, Francisco Javier, Díaz-Olavarrieta, Claudia, Valdés, Paloma Almeda, Muñóz-Hernández, Linda Liliana, Mehta, Roopa Pravin, Elías-López, Daniel, Tusié-Luna, Teresa, Pajukanta, Päivi, Sukhatme, Mihir G., Moreno-Macías, Hortensia, Ruth, Johnson, González-Behn-Eschenburg, Sebastián, García-Grimshaw, Miguel, Guillen-Pineda, Luz Elizabeth, de los Ángeles Vargas-Martínez, María, Rodríguez, Maribel, Rodríguez-Guillén, Rosario, Ordoñez, María Luisa, Rajme-López, Sandra, González-Lara, María Fernanda, Luna-Moreno, Dalia, de Jesús Suárez López, Jannet, Guillén-Quintero, Daniela Mariel, Vega, Juan, Duran-Coyote, Salvador, Guerra-García, María Teresa, Durán-Gómez, Michelle, Vigueras-Hernández, Alma, Ramírez-Jiménez, Marco Eduardo, Grajeda-González, Samara Lissete, Ramos-Galicia, Enrique Manuel, Ramírez-Carrillo, Martha Fernanda, Fernandez-Ruiz, Juan, Chirino-Pérez, Amanda, Romero-Molina, Ángel Omar, Zavaleta, David Alejandro Fuentes, Jaramillo, María Andrea Mac Donald, López, Katia Jarely Prieto, Incontri-Abraham, Diego, Rosado, Wendy Natalia, Catalán, María Alonso, Aguilar, Sonia Evelyn Vital, Zamudio, Ileana Paola Montero, Ruíz-Ruíz, Eduardo, de Jesús Carrera García, Kevin, Guerrero, Cristina Villarreal, Martínez, Ana Isabel Rodríguez, Moscoso-Sánchez, Rogelio, del Consuelo Rodríguez Mancilla, María, Villa, Antonio, Luna-Ramírez, Samuel Alejandro, Hernández-Hernández, Sergio, Frias, Erika, Campos, Alejandro, Morales-Sosa, Paola Alessandra, Toxqui-Merchant, Luis Enrique, García, Karla, Pasaniuc, Bogdan, Butte, Manish J., Geschwind, Daniel H., Aguilar-Salinas, Carlos A., Heidecker, Bettina, Kurth, Florian, Sander, Leif E., Skurk, Carsten, Landmesser, Ulf, Karadeniz, Zehra, Wang, Xiaomin, Poller, Wolfgang, Suwalski, Phillip, Ripke, Stephan, Braun, Alice, Kraft, Julia, Mayer, Alena, Lippert, Lena J., Helbig, Elisa T., Thibeault, Charlotte, Awasthi, Swapnil, Mbarek, Hamdi, Saad, Chadi, Al-Sarraj, Yaser, Badji, Radja Messai, Al-Muftah, Wadha, Thani, Asma Al, Afifi, Nahla, Sadiq, Fouzia, Khan, Mohammad I., Bhutta, Muhammad J., Khan, Hania, Khan, Madeeha, Ain, Quratul, Junaid, Ayesha, Khan, Ejaz A., Sypniewski, Mateusz, Lejman, Adrian, Zawadzki, Paweł, Sztromwasser, Paweł, Król, Zbigniew, Dobosz, Paula, Stojak, Joanna, Flores, Carlos, Carracedo, Ángel, Aguilar, Carlos, Arranz, María J., Baptista-Rosas, Raúl C., Bezerra, Joao F., Bezerra, Marcos A. C., Brugada, Ramón, Bustos, Matilde, Castano, Luis, Conde-Vicente, Rosa, Cordero-Lorenzana, M. Lourdes, De Martino-Rodríguez, Alba, Domínguez-Garrido, Elena, Fariñas, María Carmen, Gil-Fournier, Belén, Herrero, María José, Lattig, María Claudia, Martín-López, Caridad, Martín, Vicente, Martinez-Nieto, Oscar, Martinez-Lopez, Iciar, Mazzeu, Juliana F., Macías, Eleuterio Merayo, Cuerda, Victor Moreno, Silbiger, Vivian N., Oliveira, Silviene F., Parellada, Mara, Santos, Ney P. C., Pérez-Matute, Patricia, Perez, Patricia, Perucho, Teresa, Porras-Hurtado, Gloria L., Pujol, Aurora, Fernández-Rodríguez, Amanda, Jimenez-Sousa, María A., Rodríguez-Ruiz, Emilio, Rodriguez-Artalejo, Fernando, Rodriguez-Garcia, José A., Ruiz-Cabello, Francisco, Soria, José Manuel, Tamayo, Eduardo, Teper, Alejandro, Torres-Tobar, Lilian, Urioste, Miguel, Yáñez, Zuleima, Zarate, Ruth, Guillen-Navarro, Encarna, Ayuso, Carmen, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Lapunzina, Pablo, Cruz, Raquel, Diz-de Almeida, Silvia, Ceballos, Francisco C., Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Quintela, Inés, Pita, Guillermo, Gago-Domínguez, Manuela, Porras, Marta Sevilla, Tenorio-Castaño, Jair Antonio, Nevado, Julian, Aguado, Jose María, Aguilera-Albesa, Sergio, Almadana, Virginia, Almoguera, Berta, Alvarez, Nuria, Andreu-Bernabeu, Álvaro, Arango, Celso, Artiga, Maria-Jesus, Barreda-Sánchez, María, Belhassen-Garcia, Moncef, Boix-Palop, Lucía, Brion, María, Carbonell, Cristina, Castelao, Jose E., Cortes-Sanchez, Jose L., Corton, Marta, Darnaude, M. Teresa, del Campo-Pérez, Victor, de Bustamante, Aranzazu Diaz, Luchessi, Andre D., Eiros, Rocío, Sanabria, Gladys Mercedes Estigarribia, Fernández-Robelo, Uxía, Fernández-Villa, Tania, Gómez-Arrue, Javier, Álvarez, Beatriz González, de Quirós, Fernan Gonzalez Bernaldo, González-Peñas, Javier, Gutiérrez-Bautista, Juan F., Herrero-Gonzalez, Antonio, Borja, Anabel Liger, Lopez-Rodriguez, Rosario, Mancebo, Esther, Martinez-Resendez, Michel F., Martinez-Perez, Angel, Minguez, Pablo, Ortega-Paino, Eva, Paz-Artal, Estela, Pérez-Tomás, M. Elena, Pinsach-Abuin, Mel·lina, Pompa-Mera, Ericka N., León, Soraya Ramiro, Resino, Salvador, Fernandes, Marianne R., Ruiz-Hornillos, Javier, Ryan, Pablo, Souto, Juan Carlos, Tamayo-Velasco, Alvaro, Taracido-Fernandez, Juan Carlos, Valencia-Ramos, Juan, de Heredia, Miguel López, Pedersen, Ole B., Erikstrup, Christian, Ostrowski, Sisse R., Stefansson, Kari, Mikkelsen, Susan, Sørensen, Erik, Burgos, Celia, Andersen, Steffen, Brugdorf, Kristoffer, Hansen, Thomas F., Hjalgrim, Henrik, Jemec, Gregor B., Nyegaard, Mette, Werge, Thomas, Johansson, Pär I., Didriksen, Maria, Schwinn, Michael, Jacobsen, Rikke L., Hindhede, Lotte, Rostgaard, Klaus, Gudbjartsson, Daniel, Stefánsson, Hreinn, Þorsteinsdóttir, Unnur, Nielsen, Kaspar R., Bruun, Mie Topholm, Dinh, Khoa M., Larsen, Margit A. H., Sækmose, Susanne G., Zeberg, Hugo, Nkambul, Lindo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklos, Tardif, Nicolas, Rooyackers, Olav, Grip, Jonathan, Maricic, Tomislav, Heid, Iris M., Wagner, Ralf, Überla, Klaus, Winkler, Thomas W., Wiegrebe, Simon, Gorski, Mathias, Stark, Klaus J., Peterhoff, David, Einhauser, Sebastian, Niller, Hans-Helmut, Beileke, Stephanie, Johnson, Ruth, Freimer, Nelson, Ding, Yi, Chiu, Alec, Chang, Timothy S., Boutros, Paul, Karczewski, Konrad J., Martin, Alicia R., Wilson, Daniel J., Spencer, Chris C. A., Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikolas, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Solomonson, Matthew, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline I., King, Daniel, Zhou, Wei, Seed, Cotton, Daly, Mark J., Finucane, Hilary, Bryant, Sam, Satterstrom, F. Kyle, Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicolas, Koelling, Nils, Armstrong, Jacob, Rudkin, Justine K., Callier, Shawneequa, Cusick, Caroline, Fernandez-Cadenas, Israel, Planas, Anna M., Perez-Tur, Jordi, Llucià-Carol, Laia, Cullell, Natalia, Muiño, Elena, Cárcel-Márquez, Jara, DeDiego, Marta L., Iglesias, Lara Lloret, Soriano, Alex, Rico, Veronica, Agüero, Daiana, Bedini, Josep L., Lozano, Francisco, Domingo, Carlos, Robles, Veronica, Ruiz-Jaén, Francisca, Márquez, Leonardo, Gomez, Juan, Coto, Eliecer, Albaiceta, Guillermo M., García-Clemente, Marta, Dalmau, David, Arranz, Maria J., Dietl, Beatriz, Serra-Llovich, Alex, Soler-Palacin, Pere, Colobran, Roger, Martin-Nalda, Andrea, Parra-Martínez, Alba, Bernardo, David, Rojo, Silvia, Fiz-López, Aida, Arribas-Rodriguez, Elisa, Cal-Sabater, Paloma, Segura, Tomás, González-Villar, Esther, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Jiménez-Xarrié, Elena, de Felipe Mimbrera, Alicia, Masjuan, Jaime, García-Madrona, Sebastian, Domínguez-Mayoral, Anna, Villalonga, Joan Montaner, Menéndez-Valladares, Paloma, Kanai, M, Andrews, S, Cordioli, M, Stevens, C, Neale, B, Daly, M, Ganna, A, Pathak, G, Iwasaki, A, Karjalainen, J, Mehtonen, J, Pirinen, M, Chwialkowska, K, Trankiem, A, Balaconis, M, Veerapen, K, Wolford, B, Ahmad, H, von Hohenstaufen Puoti, K, Boer, C, Boua, P, Butler-Laporte, G, Cadilla, C, Chwiałkowska, K, Colombo, F, Douillard, V, Dueker, N, Dutta, A, El-Sherbiny, Y, Eltoukhy, M, Esmaeeli, S, Faucon, A, Fave, M, Cadenas, I, Francescatto, M, Francioli, L, Franke, L, Fuentes, M, Durán, R, Cabrero, D, Harry, E, Jansen, P, Szentpéteri, J, Kaja, E, Kirk, C, Kousathanas, A, Krieger, J, Patel, S, Lemaçon, A, Limou, S, Lió, P, Marouli, E, Marttila, M, Medina-Gómez, C, Michaeli, Y, Migeotte, I, Mondal, S, Moreno-Estrada, A, Moya, L, Nakanishi, T, Nasir, J, Pasko, D, Pearson, N, Pereira, A, Priest, J, Prijatelj, V, Prokić, I, Teumer, A, Várnai, R, Romero-Gómez, M, Roos, C, Rosenfeld, J, Ruolin, L, Schulte, E, Schurmann, C, Sedaghati-khayat, B, Shaheen, D, Shivanathan, I, Sipeky, C, Sirui, Z, Striano, P, Tanigawa, Y, Remesal, A, Vadgama, N, Vallerga, C, van der Laan, S, Verdugo, R, Wang, Q, Wei, Z, Zainulabid, U, Zárate, R, Auton, A, Shelton, J, Shastri, A, Weldon, C, Filshtein-Sonmez, T, Coker, D, Symons, A, Aslibekyan, S, O’Connell, J, Ye, C, Hatoum, A, Agrawal, A, Bogdan, R, Colbert, S, Thompson, W, Fan, C, Johnson, E, Niazyan, L, Davidyants, M, Arakelyan, A, Avetyan, D, Bekbossynova, M, Tauekelova, A, Tuleutayev, M, Sailybayeva, A, Ramankulov, Y, Zholdybayeva, E, Dzharmukhanov, J, Kassymbek, K, Tsechoeva, T, Turebayeva, G, Smagulova, Z, Muratov, T, Khamitov, S, Kwong, A, Timpson, N, Niemi, M, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Gofflot, S, Bouysran, Y, Busson, A, Peyrassol, X, Wilkin, F, Pichon, B, Smits, G, Vandernoot, I, Goffard, J, Tiembe, N, Morrison, D, Afilalo, J, Mooser, V, Richards, J, Rousseau, S, Durand, M, Forgetta, V, Laurent, L, Afrasiabi, Z, Bouab, M, Tselios, C, Xue, X, Afilalo, M, Oliveira, M, St-Cyr, J, Boisclair, A, Ragoussis, J, Auld, D, Kaufmann, D, Lathrop, G, Bourque, G, Décary, S, Falcone, E, Montpetit, A, Piché, A, Renoux, C, Tremblay, K, Tse, S, Zawati, M, Davis, L, Cox, N, Below, J, Sealock, J, Shuey, M, Polikowsky, H, Petty, L, Shaw, D, Chen, H, Zhu, W, Schmidt, A, Ludwig, K, Maj, C, Rolker, S, Balla, D, Behzad, P, Nöthen, M, Fazaal, J, Keitel, V, Jensen, B, Feldt, T, Marx, N, Dreher, M, Pink, I, Cornberg, M, Illig, T, Lehmann, C, Schommers, P, Rybniker, J, Augustin, M, Knopp, L, Kurth, I, Eggermann, T, Volland, S, Berger, M, Brenner, T, Hinney, A, Witzke, O, Konik, M, Bals, R, Herr, C, Ludwig, N, Walter, J, Latz, E, Schmidt, S, Brooks, J, Bull, S, Elliott, L, Gagnon, F, Greenwood, C, Hung, R, Lawless, J, Paterson, A, Sun, L, Rauh, M, Briollais, L, Gingras, A, Bombard, Y, Pugh, T, Simpson, J, Goneau, L, Halevy, A, Maslove, D, Borgundvaag, B, Devine, L, 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C., Thompson, Wesley K., Fan, Chun Chieh, Johnson, Emma C., Niazyan, Lyudmila, Davidyants, Mher, Arakelyan, Arsen, Avetyan, Diana, Bekbossynova, Makhabbat, Tauekelova, Ainur, Tuleutayev, Mukhtar, Sailybayeva, Aliya, Ramankulov, Yerlan, Zholdybayeva, Elena, Dzharmukhanov, Jarkyn, Kassymbek, Kuat, Tsechoeva, Tatyana, Turebayeva, Gulsimzhan, Smagulova, Zauresh, Muratov, Timur, Khamitov, Sadyk, Kwong, Alex S. F., Timpson, Nicholas J., Niemi, Mari E. K., Rahmouni, Souad, Guntz, Julien, Beguin, Yves, Pigazzini, Sara, Nkambule, Lindokuhle, Georges, Michel, Moutschen, Michel, Misset, Benoit, Darcis, Gilles, Gofflot, Stéphanie, Bouysran, Youssef, Busson, Adeline, Peyrassol, Xavier, Wilkin, Françoise, Pichon, Bruno, Smits, Guillaume, Vandernoot, Isabelle, Goffard, Jean-Christophe, Tiembe, Nicky, Morrison, David R., Afilalo, Jonathan, Mooser, Vincent, Richards, J. 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Mark, Bourque, Guillaume, Décary, Simon, Falcone, Emilia Liana, Montpetit, Alexandre, Piché, Alain, Renoux, Christel, Tremblay, Karine, Tse, Sze Man, Zawati, Ma’n H., Davis, Lea K., Cox, Nancy J., Below, Jennifer E., Sealock, Julia M., Faucon, Annika B., Shuey, Megan M., Polikowsky, Hannah G., Petty, Lauren E., Shaw, Douglas M., Chen, Hung-Hsin, Zhu, Wanying, Schmidt, Axel, Ludwig, Kerstin U., Maj, Carlo, Rolker, Selina, Balla, Daniella, Behzad, Pari, Nöthen, Markus M., Fazaal, Julia, Keitel, Verena, Jensen, Björn-Erik Ole, Feldt, Torsten, Marx, Nikolaus, Dreher, Michael, Pink, Isabell, Cornberg, Markus, Illig, Thomas, Lehmann, Clara, Schommers, Philipp, Rybniker, Jan, Augustin, Max, Knopp, Lisa, Kurth, Ingo, Eggermann, Thomas, Volland, Sonja, Berger, Marc M., Brenner, Thorsten, Hinney, Anke, Witzke, Oliver, Konik, Margarethe J., Bals, Robert, Herr, Christian, Ludwig, Nicole, Walter, Jörn, Latz, Eicke, Schmidt, Susanne V., Brooks, Jennifer D., Bull, Shelley, Elliott, Lloyd T., Gagnon, France, Greenwood, Celia M. T., Hung, Rayjean J., Lawless, Jerry F., Paterson, Andrew D., Sun, Lei, Rauh, Michael, Briollais, Laurent, Gingras, Anne-Claude, Bombard, Yvonne, Pugh, Trevor J., Simpson, Jared, Goneau, Lee W., Halevy, Anat R., Maslove, David M., Borgundvaag, Bjug, Devine, Luke, Bearss, Erin, Richardson, David, Arnoldo, Saranya, Friedman, Steven Marc, Taher, Ahmed, Stern, Seth, Dagher, Marc, Vasilevska-Ristovska, Jovanka, Biggs, Catherine M., Mickiewicz, Beata, Strug, Lisa J., Scherer, Stephen W., Aziz, Naveed, Jones, Steven J. M., Knoppers, Bartha M., Lathrop, Mark, Turvey, Stuart E., Yeung, Rae S. M., Allen, Upton, Cheung, Angela M., Herridge, Margaret S., Hunt, Miranda, Lerner-Ellis, Jordan, Taher, Jennifer, Parekh, Rulan S., Hiraki, Linda T., Cowan, Juthaporn, Ducharme, Francine M., Ostrowski, Mario, Bernier, Francois P., Kellner, Jim, Garg, Elika, Yoo, Samantha, Vlasschaert, Caitlyn, Frangione, Erika, Chung, Monica, Noor, Abdul, Greenfeld, Elena, Colwill, Karen, Clausen, Marc, Chao, Gary, Yue, FengYun, Fritzler, Marvin, Whitney, Joseph, Thiruvahindrapuram, Bhooma, Garant, Jean-Michel, Abraham, Rohan, Davis, Adrienne, Campigotto, Aaron, Papenburg, Jesse, Niranjan, Kissoon, Betschel, Stephen, Sadarangani, Manish, Barton-Forbes, Michelle, Hanley, Michaela, Fung, Chun Yiu Jordan, Lapadula, Elisa, MacDonald, Georgia, Puopolo, Michael, Kaushik, Deepanjali, Nirmalanathan, Konika, Wong, Iris, Khan, Zeeshan, Zarei, Natasha, Michalowska, Maria, Modi, Bhavi P., Persia, Pourshahnazari, Estacio, Antonio, Buchholz, Megan, Cheatley, Patti Lou, Lorenti, Miranda, Aman, Nowrin F., Matveev, 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Tsourlos, Stavros, Athanasiou, Lazaros, Kolios, Nikolaos-Gavriil, Pappa, Christiana, Papathanasiou, Alexandros, Pargana, Eleni, Nasiou, Maria, Kosmidou, Maria, Rapti, Iro, Ntotsikas, Evangelos, Chaliasos, Konstantinos, Ntzani, Evangelia, Evangelou, Evangelos, Gartzonika, Konstantina, Georgiou, Ioannis, Tzoulaki, Ioanna, Ellinghaus, David, Degenhardt, Frauke, Cáceres, Mario, Juzenas, Simonas, Lenz, Tobias L., Albillos, Agustín, Julià, Antonio, Prati, Daniele, Solligård, Erik, Garcia, Federico, Tran, Florian, Hanses, Frank, Baselli, Guido, Zoller, Heinz, Holter, Jan Cato, Fernández, Javier, Barretina, Jordi, Valenti, Luca, Bujanda, Luis, Buti, Maria, D’Amato, Mauro, Banales, Jesus M., Rosenstiel, Philip, Koehler, Philipp, Invernizzi, Pietro, de Cid, Rafael, Asselta, Rosanna, Schreiber, Stefan, Duga, Stefano, Hehr, Ute, Franke, Andre, Maya-Miles, Douglas, Hov, Johannes R., Karlsen, Tom H., Folseraas, Trine, Teles, Ana, Tanck, Anja, Gassner, Christoph, Azuure, Clinton, Wacker, Eike Matthias, Uellendahl-Werth, Florian, Hemmrich-Stanisak, Georg, ElAbd, Hesham, Kässens, Jan, Arora, Jatin, Lerga-Jaso, Jon, Wienbrandt, Lars, Rühlemann, Malte Christoph, Wendorff, Mareike, Figuera Basso, Maria E., Vadla, May Sissel, Wittig, Michael, Braun, Nicole, Lenning, Ole Bernt, Özer, Onur, Myhre, Ronny, Raychaudhuri, Soumya, Wesse, Tanja, Albrecht, Wolfgang, Yi, Xiaoli, Ortiz, Aaron Blandino, de Salazar, Adolfo, Chercoles, Adolfo Garrido, Palom, Adriana, Ruiz, Agustín, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Holten, Aleksander Rygh, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Nebel, Almut, Barreira, Ana, Lleo, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Nolla, Anna Carreras, Latiano, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, Muscatello, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Cortes, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Bellinghausen, Carla, Ferrando, Carlos, de la Horra, Carmen, Quereda, Carmen, Scollo, Chiara, Lange, Christoph, Hu, Cinzia, Paccapelo, Cinzia, Angelini, Claudio, Cappadona, Claudio, Bianco, Cristiana, Cea, Cristina, Sancho, Cristina, Hoff, Dag Arne Lihaug, Galimberti, Daniela, Haschka, David, Jiménez, David, Pestaña, David, Toapanta, David, Muñiz-Diaz, Eduardo, Azzolini, Elena, Sandoval, Elena, Binatti, Eleonora, Scarpini, Elio, Casalone, Elisabetta, Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, Calderón, Enrique J., Navas, Enrique, Contro, Ernesto, Arana-Arri, Eunate, Aziz, Fátima, Sánchez, Félix García, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Blasi, Francesco, Malvestiti, Francesco, Medrano, Francisco J., Mesonero, Francisco, Rodriguez-Frias, Francisco, Müller, Fredrik, 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Valsecchi, Maria G., Hernandez-Tejero, María, Vehreschild, Maria J. 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T., Manunta, Maria, Acosta-Herrera, Marialbert, D’Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Marquié, Marta, Castoldi, Massimo, Cecconi, Maurizio, Tomasi, Melissa, Boada, Mercè, Joannidis, Michael, Mazzocco, Michela, Ciccarelli, Michele, Rodríguez-Gandía, Miguel, Bocciolone, Monica, Miozzo, Monica, Ayo, Natale Imaz, Blay, Natalia, Chueca, Natalia, Montano, Nicola, Martínez, Nilda, Cornely, Oliver A., Palmieri, Orazio, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Tentorio, Paolo, Castro, Pedro, Rodrigues, Pedro M., Izquierdo-Sanchez, Laura, España, Pedro Pablo, Hoffmann, Per, Bacher, Petra, de Pablo, Raúl, Ferrer, Ricard, Gualtierotti, Roberta, Gallego-Durán, Rocío, Nieto, Rosa, Carpani, Rossana, Morilla, Rubén, Badalamenti, Salvatore, Haider, Sammra, Ciesek, Sandra, Bombace, Sara, Marsal, Sara, Klein, Sebastian, Pelusi, Serena, Wilfling, Sibylle, Goerg, Siegfried, Bosari, Silvano, Brunak, Søren, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Dudman, Susanne, Zheng, Tenghao, Bahmer, Thomas, Pumarola, Tomas, Cejudo, Trinidad Gonzalez, Rimoldi, Valeria, Monzani, Valter, Skogen, Vegard, Friaza, Vicente, Andrade, Victor, Moreno, Victor, Peter, Wolfgang, Farre, Xavier, Khodamoradi, Yascha, Grimsrud, Marit M., May, Sandra, Colombo, Alicia, Virginia, Monardes-Ramírez A., Dorador, Cristina, Fuentes-Guajardo, Macarena, Silva, Andrea X., Espinosa-Parrilla, Yolanda, Yáñez, Cristian E., Retamales-Ortega, Rocío M., Saez Hidalgo, Juan M., Tobar-Calfucoy, Eduardo A., Carvajal-Silva, Laura, Martínez, Matías F., Cerpa, Leslie C., Christian, Muñoz A., Cappelli, Claudio, Valenzuela-Jorquera, Hector, Zapata-Contreras, Daniela, Zuñiga-Pacheco, Paula, Nova-Lamperti, Estefania A., Sanhueza, Sergio A., Donoso, Gerardo, Bocchieri, Pamela, Kochifas, Pia, Quiñones, Luis A., Pedersen, Ole Birger, Geller, Frank, Westergaard, David, Sequeros, Celia Burgos, Nissen, Janna, Nielsen, Susanne Dam, Feldt-Rasmussen, Ulla, Bliddal, Sofie, Grønbæk, Kirsten, Ullum, Henrik, Ostrowski, Sisse Rye, Feenstra, Bjarke, Shahin, Doaa, Sobh, Ali, Shoma, Ashraf, Nkambul, Lindokuhle, Elhadidy, Tamer A., Abd Elghafar, Mohamed S., El-Jawhari, Jehan J., Mohamed, Attia A. S., Elnagdy, Marwa H., Samir, Amr, Abdel-Aziz, Mahmoud, Khafaga, Walid T., El-Lawaty, Walaa M., Torky, Mohamed S., El-Shanshory, Mohamed R., Elzeiny, Ahmed, Rashad, Amal, Mansour, Tamer A., Yassen, Amr M., Hegazy, Mohamed A. F., Okasha, Kamal, Eid, Mohammed A., Hanteera, Moahmed S., Medina-Gomez, Carolina, Ikram, M. Arfan, Uitterlinden, Andre G., Ripatti, Samuli, Jermy, Bradley, Ruotsalainen, Sanni, Kristiansson, Kati, Koskelainen, Sami, Perola, Markus, Donner, Kati, Kivinen, Katja, Palotie, Aarno, Kaunisto, Mari, Julienne, Hanna, Aschard, Hugues, Deleuze, Jean-Francois, Debette, Stephanie, Tregouet, David-Alexandre, Abel, Laurent, Henches, Léo, Lefloch, Edith, Claire, Dandine-Roulland, Sakuntabhai, Anavaj, Bourgeron, Thomas, Olaso, Robert, Daian, Delphine Bacq, Pellegrin, Isabelle, Casanova, Jean-Laurent, Cobat, Aurélie, Jouanguy, Emmanuelle, Zhang, Qian, Ghosn, Jade, Mentré, France, Laouénan, Cédric, Tubiana, Sarah, Chirouze, Catherine, Quintana-Murci, Luis, Patin, Etienne, Duffy, Darragh, Boland, Anne, Carreras, Anna, Galván-Femenía, Iván, Farré, Xavier, Cortés, Beatriz, Mercader, Josep Maria, Guindo-Martinez, Marta, Torrents, David, Garcia-Aymerich, Judith, Castaño-Vinyals, Gemma, Dobaño, Carlota, van Heel, David A., Hunt, Karen A., Trembath, Richard C., Jacobs, Benjamin Meir, Huang, Qin Qin, Martin, Hilary C., Mason, Dan, Trivedi, Bhavi, Wright, John, Munisamy, Malathy, Finer, Sarah, Griffiths, Christopher J., McCarthy, Mark I., Rosenberger, Carrie, Lee, Jong Eun, Chang, Diana, Hammer, Christian, Hunkapiller, Julie, Mahajan, Anubha, Pendergrass, Rion, Sucheston-Campbell, Lara, Yaspan, Brian, Lee, Hyun Soo, Shin, Eunsoon, Jang, Hye Yoon, Kim, Sunmie, Kym, Sungmin, Kim, Yeon-Sook, Jeong, Hyeongseok, Kwon, Ki Tae, Kim, Shin-Woo, Kim, Jin Yong, Jang, Young Rock, Kim, Hyun ah, Lee, Ji yeon, Lee, Jeong Eun, Lee, Shinwon, Choe, Kang-Won, Kang, Yu Min, Jee, Sun Ha, Jung, Keum Ji, Park, Hyun-Young, Kim, Bong-Jo, Kim, Young Jin, Hwang, Mi Yeong, Yoon, Kyungheon, Pairo-Castineira, Erola, Rawlik, Konrad, Caulfield, Mark J., Baillie, J. Kenneth, Griffiths, Fiona, Bretherick, Andrew D., Stuckey, Alex, Odhams, Christopher A., Walker, Susan, Russell, Clark D., Malinauskas, Tomas, Wu, Yang, Shen, Xia, Elliott, Katherine S., Morrice, Kirstie, Keating, Sean, Wang, Bo, Rhodes, Daniel, Klaric, Lucija, Zechner, Marie, Parkinson, Nick, Fawkes, Angie, Murphy, Lee, Vitart, Veronique, Wilson, James F., Yang, Jian, Scott, Richard H., Moutsianas, Loukas, Law, Andy, Begg, Colin, Hendry, Sara Clohisey, Hinds, Charles, Horby, Peter, Knight, Julian, Ling, Lowell, Maslove, David, McAuley, Danny, Millar, Johnny, Montgomery, Hugh, Nichol, Alistair, Openshaw, Peter J. M., Ponting, Chris P., Rowan, Kathy, Semple, Malcolm G., Shankar-Hari, Manu, Summers, Charlotte, Walsh, Timothy, Pan, Jacqueline, Grau, Neus, Jones, Tim Owen, Lim, Rosario, Marotti, Martina, Whitton, Christopher, Bociek, Aneta, Campos, Sara, Arbane, Gill, Ostermann, Marlies, Cha, Mina, DAmato, Fabiola, Kosifidou, Eirini, Lorah, Shelley, Morera, Kyma, Brady, Laura, Hugill, Keith, Henning, Jeremy, Bonner, Stephen, Headlam, Evie, Jones, Jessica, List, Abigail, Morley, Joanne, Welford, Amy, Kamangu, Bobette, Ratnakumar, Anitha, Shoremekun, Abiola, Alldis, Zoe, Astin-Chamberlain, Raine, Bibi, Fatima, Biddle, Jack, Blow, Sarah, Bolton, Matthew, Borra, Catherine, Bowles, Ruth, Burton, Maudrian, Choudhury, Yasmin, Cox, Amber, Easthope, Amy, Ebano, Patrizia, Fotiadis, Stavros, Gurasashvili, Jana, Halls, Rosslyn, Hartridge, Pippa, Kallon, Delordson, Kassam, Jamila, Lancoma-Malcolm, Ivone, Matharu, Maninderpal, May, Peter, Mitchelmore, Oliver, Newman, Tabitha, Patel, Mital, Pheby, Jane, Pinzuti, Irene, Prime, Zoe, Prysyazhna, Oleksandra, Shiel, Julian, Taylor, Melanie, Tierney, Carey, Zongo, Olivier, Wood, Suzanne, Zak, Anne, Collier, David, Mundy, Manuela, Thompson, Christopher, Pritchard, Lisa, Gellamucho, Minnie, Cartlidge, David, Bandla, Nageswar, Bailey, Lucy, Davies, Michelle, Delaney, Jane, Scott, Leanne, Abdelrazik, Marwa, Alasdair, Frater, Carter, David, Elhassan, Munzir, Ganesan, Arunkumar, Jenkins, Samuel, Lamond, Zoe, Purohit, Dharam, Rohit, Kumar, Saleem, Malik, Wall, Alanna, Xavier, Kugan, Bakthavatsalam, Dhanalaksmi, Gehad, Kirolos, Gnanapragasam, Pakeerathan, Jain, Kapil, Jain, Swati, Malik, Abdul, Pappachan, Naveen, Moreno-Cuesta, Jeronimo, Haldeos, Anne, Vincent, Rachel, Oziegb, Maryjane, Cavazza, Anna, Cockrell, Maeve, Corcoran, Eleanor, Depante, Maria, Finney, Clare, Jerome, Ellen, Knighton, Abigail, Nayak, Monalisa, Pappa, Evita, Saha, Rohit, Saha, Sian, Dodd, Andrew, O’Reilly, Kevin, McPhail, Mark, Clarey, Emma, Noble, Harriet, Smith, John, Coghlan, Phoebe, Brett, Stephen, Gordon, Anthony, Templeton, Maie, Antcliffe, David, Banach, Dorota, Darnell, Sarah, Fernandez, Ziortza, Jepson, Eleanor, Mohammed, Amal, Rojo, Roceld, Arias, Sonia Sousa, Gurung, Anita Tamang, Wong, Jenny, Fernandez-Roman, Jaime, Hamilton, David O., Johnson, Emily, Johnston, Brian, Martinez, Maria Lopez, Mulla, Suleman, Waite, Alicia A. C., Williams, Karen, Waugh, Victoria, Welters, Ingeborg, Emblem, Jessica, Norris, Maria, Shaw, David, Bashyal, Archana, Beer, Sally, Hutton, Paula, McKechnie, Stuart, Davidson, Neil, Mathew, Soya, Readion, Grace, Ryu, Jung, Wilson, Jean, Agrawal, Shruti, Elston, Kay, Jones, Megan, Meaney, Eoghan, Polgarova, Petra, Elbehery, Muhammad, Daubney, Esther, Ng, Anthony, Marshall, Jocelyn, Pathan, Nazima, Stroud, Katerina, White, Deborah, Andrew, Angela, Ashraf, Saima, Clark, Amy, Dent, Martin, Langley, Margaret, Peters, Cecilia, Ryan, Lucy, Sampson, Julia, Wei, Shuying, Baddeley, Alice, Meredith, Megan, Morris, Lucy, Gibbons, Alexandra, McLoughlin, Lisa, Delgado, Carlos Castro, Clark, Victoria, Dawson, Deborah, Ding, Lijun, Durrant, Georgia, Ezeobu, Obiageri, Harrison, Abiola, Hurt, William James, Kanu, Rebecca, Kinch, Ashley, Leaver, Susannah, Lisboa, Ana, Mathew, Jisha, Patel, Kamal, Saluzzio, Romina Pepermans, Rawlins, John, Samakomva, Tinashe, Shah, Nirav, Sicat, Christine, Texeira, Joana, Queiroz, Joana Gomes De, Gloria, Edna Fernandes Da, Maccacari, Elena, Yun, Nikki, Manna, Soumendu, Farnell-Ward, Sarah, Maizcordoba, Maria, Thanasi, Maria, Ali, Hawakin Haji, Hastings, Janice, Grauslyte, Lina, Hussain, Musarat, Ruge, Bobby, King, Sam, Pogreban, Tatiana, Rosaroso, Lace, Smith, Helen, Phull, Mandeep-Kaur, Adams, Nikkita, Franke, George, George, Aparna, Salciute, Erika, Wong, Joanna, Dunne, Karen, Flower, Luke, Sharland, Emma, Sra, Sukhmani, Andrew, Gillian, Callaghan, Marie, Barclay, Lucy, Marshall, Lucy, Amamio, Maria, Birch, Sophie, Briton, Kate, Clark, Sarah, Doverman, Katerine, Hope, Dave, Mcculloch, Corrienne, Simpson, Scott, Singleton, Jo, Fernandez, Rita, Allen, Meryem, Baptista, David, Crowe, Rebecca, Fox, Jonathan, Khera, Jacyntha, Loveridge, Adam, McKenley, India, Morino, Eriko, Naranjo, Andres, O’Connor, Denise, Simms, Richard, Sollesta, Kathryn, Swain, Andrew, Venkatesh, Harish, Herdman-Grant, Rosie, Joseph, Anna, Nown, Angela, Rose, Steve, Pogson, David, Boxall, Helen, Brimfield, Lutece, Claridge, Helen, Daly, Zoe, George, Shenu, Gribbin, Andrew, Cheema, Yusuf, Cutler, Sean, Richards, Owen, Roynon-Reed, Anna, Cherian, Shiney, Heron, Anne Emma, Williams, Gemma, Szakmany, Tamas, Waters, Abby, Collins, Kim, Dunhill, Jill, Jones, Ffion, Morris, Rebecca, Ship, Lucy, Cardwell, Amy, Ali, Syamlan, Bhatterjee, Ravi, Bolton, Rachel, Chukkambotla, Srikanth, Coleman, Dabheoc, Dalziel, Jack, Dykes, Joseph, Fine, Christopher, Gay, Bethan, Goddard, Wendy, Goodchild, Drew, Harling, Rhiannan, Hijazi, Muhammad, Keith, Sarah, Khan, Meherunnisa, Matt, Roseanna, Ryan-Smith, Janet, Saad, Samuel, Springle, Philippa, Thomas, Jacqueline, Truman, Nick, Kazi, Aayesha, Smith, Matthew, Collier, Heather, Davison, Chloe, Duberley, Stephen, Hargreaves, Jeanette, Hartley, Janice, Patel, Tahera, Smith, Ellen, Kent, Alissa, Goodwin, Emma, Zaki, Ahmed, Tibke, Clare, Hopkins, Susan, Gerrard, Hywel, Jackson, Matthew, Bennett, Sara, Marsh, Liane, Mills, Rebecca, Bell, Jessica, Campbell, Helen, Dawson, Angela, Dodds, Steve, Duffy, Stacey, Gallagher, Lisa, McCafferty, Gemma, Short, Stacey, Smith, Tracy, Thomas, Kirsty, Walker, Claire, Reynolds, Jessica, Yates, Bryan, McKie, Hayley, Panteli, Maria, Thompson, Maria, Waddell, Gail, Beger, Sarah De, Abraheem, Azmerelda, Dunmore, Charlie, Girach, Rumanah, Jones, Rhianna, London, Emily, Nagra, Imrun, Nasir, Farah, Sainsbury, Hannah, Smedley, Clare, Brearey, Stephen, Burchett, Caroline, Cawley, Kathryn, Faulkner, Maria, Jeffrey, Helen, Bamford, Peter, Shaikh, Firdaus, Slack, Lauren, Davies, Angela, Brooke, Hollie, Suarez, Jose Cebrian, Charlesworth, Ruth, Hansson, Karen, Norris, John, Poole, Alice, Sandhu, Rajdeep, Smithson, Elizabeth, Thirumaran, Muthu, Wagstaff, Veronica, Buckley, Sarah, Sloan, Brendan, Rose, Alastair, Major, Amy, Metcalfe, Alexandra, Almaden-Boyle, Christine, Austin, Pauline, Chapman, Susan, Eros, Alexandre, Cabrelli, Louise, Cole, Stephen, Whyte, Clare, Casey, Matt, Bafitis, Vasileios, Tsinaslanidis, George, George, Cassandra, Khade, Reena, Black, Christopher, Ashok, Sundar Raj, Farley, Sean, Brinkworth, Elaine, Harford, Rachel, Murphy, Carl, Williams, Marie, Newey, Luke, Toghill, Hannah, Lewis, Sophie, Rees, Tabitha, Battle, Ceri, Baker, Mark, Travers, Jenny, Chesters, Karen, Baxter, Nicola, Arnott, Andrew, McCreath, Gordan, McParland, Christopher, Rooney, Laura, Sim, Malcolm, Henderson, Steven, Abel, Lynn, Dalton, Carol, Kennedy-Hay, Sophie, O’Donohoe, Lynn, O’Hare, Megan, Orlikowska, Izabela, Parker, Natasha, McNeela, Fiona, Lyle, Amanda, Hughes, Alistair, Radhakrishnan, Jayachandran, Gibson, Sian, Bancroft, Hollie, Bellamy, Mary, Daglish, Jacqueline, Kadiri, Salma, Moore, Faye, Rhodes, Joanne, Sangombe, Mirriam, Peterkin, Zhane, Scriven, James, Carmody, Margaret, Cottle, Juliet, Peasgood, Emily, de Gordoa, Laura Ortiz-Ruiz, Phillips, Claire, Skinner, Denise, Cinquina, Zoe, Howard, Kate, Joy, Rosie, Roche, Samantha, Birkinshaw, Isobel, Carter, Joseph, Ingham, Jo, Marshall, Nicola, Pearson, Harriet, Scott, Zoe, Dasgin, Jo, Gill, Jaspret, Nilsson, Annette, Bamford, Amy, Hull, Diana, Ahmadhaider, Nafeesah, Bates, Michelle, McGhee, Christopher, Ellis, Hannah, Howe, Gwenllian Sera, Singh, Jayaprakash, Stroud, Natalie, Roche, Lisa, Lynch, Ceri, Deacon, Bethan, Pothecary, Carla, Smeaton, Justyna, Agravante, Kevin, Krishnamurthy, Vinodh, Diaba, Cynthia, John, Lincy, Lim, Lai, Jha, Rajeev, Egan, Jasmine, Felton, Timothy, Glasgow, Susannah, Padden, Grace, Choudhr, Ozerah, Bradley-Potts, Joanne, Moss, Stuart, Lingeswaran, Saejohn, Alexander, Peter, Brandwood, Craig, Fiouni, Sofia, Ward, Luke, Allen, Schvearn, Shaw, Jane, Smith, Christopher, Adanini, Oluronke, Collins, Rebecca, Msiska, Maines, Ofori, Linda, Bhatia, Nikhil, Dolan, Hayley, Brunton, Mark, Caterson, Jess, Coles, Holly, Keating, Liza, Tilney, Emma, Jacques, Nicola, Frise, Matthew, Armistead, Jennifer, Bartley, Shauna, Bhuie, Parminder, Rai, Sabi, Tomkova, Gabriela, Greer, Sandra, Shuker, Karen, Tridente, Ascanio, Dobson, Emma, Hunt, Jodie, Tully, Redmond, Dearden, Joy, Drummond, Andrew, Kamath, Prakash, Bullock, Emily, Mulcahy, Michelle, Munt, Shelia, O’Connor, Grainne, Philbin, Jennifer, Rishton, Chloe, Scott, Chloe, Winnard, Sarah, Hasni, Nurkamalia, Gascoyne, Rachel, Hawes, Joanne, Pritchard, Kelly, Stevenson, Lesley, Whileman, Amanda, Beavis, Sarah, Bishop, Lauren, Cart, Cindy, Dale, Katie, Kelly-Baxter, Mary, Mendelski, Adam, Moakes, Emma, Smith, Rheanna, Woodward, Jan, Wright, Stephanie, Allan, Angela, Botello, Adriana, Liew, Jade, Medhora, Jasmine, Trumper, Erin, Savage, Felicity, Scott, Teresa, Place, Marc, Kaye, Callum, Benyon, Sarah, Marriott, Suzie, Park, Linda, Quinn, Helen, Skyes, Daisy, Zitter, Lily, Baines, Kizzy, Gordon, Elizabeth, Keenan, Samantha, Pitt, Andrew, Duffy, Katharine, Ireland, Jane, Semple, Gary, Turner, Lynne, Cathcart, Susanne, Rimmer, Dominic, Puxty, Alex, Puxty, Kathryn, Hurst, Andrew, Miller, Jennifer, Speirs, Susan, Walker, Lauren, Bradshaw, Zena, Brown, Joanna, Melling, Sarah, Preston, Stephen, Slawson, Nicola, Warden, Scott, Beasley, Alanna, Stoddard, Emma, Benham, Leonie, Cupitt, Jason, Caswell, Melanie, Elawamy, Lisa, Wignall, Ashleigh, Roberts, Belinda, Golding, Hannah, Leggett, Samantha, Male, Michelle, Marani, Martyna, Prager, Kirsty, Williams, Toran, Golder, Kim, Jones, Oliver, Cusack, Rebecca, Bolger, Clare, Burnish, Rachel, Carter, Michael, Jackson, Susan, Salmon, Karen, Biss, Jonathan, Aquino, Maia, Croft, Maria, Frost, Victoria, White, Ian, Govender, Keshnie, Webb, Natasha, Stapleton, Liana, Wells, Colin, Nikitas, Nikitas, Sanchez - Rodriguez, Ana, Spencer, Kayleigh, Stowe, Bethan, Izzard, Yvonne, Poole, Michelle, Monnery, Sonja, Trotman, Sallyanne, Beech, Valerie, Combes, Edward, Joefield, Teishel, Covernton, Patrick, Savage, Sarah, Woodward, Elizabeth, Camsooksai, Julie, Reschreiter, Henrik, Barclay, Charlotte, DeAth, Yasmin, Dube, Judith, Humphrey, Charlotte, Jenkins, Sarah, Langridge, Emma, Milne, Rebecca, Wadams, Beverley, Woolcock, Megan, Brett, Michael, Digby, Brian, Gemmell, Lisa, Hornsby, James, MacGoey, Patrick, O’Neil, Pauline, Price, Richard, Sundaram, Radha, Rodden, Natalie, Thomson, Nicola, Rooney, Kevin, Currie, Susan, Henderson, Philip, Ogg, Bethan, Whiteley, Simon, Wilby, Liz, Long, Kate, Matthew, Shailamma, Salada, Sheila, Trott, Susan, Watts, Sarah, Friar, Zoe, Speight, Abigail, Bastion, Victoria, Chandna, Humza, Djeugam, Brice, Haseeb, Muhammad, Kent, Harriet, Lubimbi, Gamu, Murdoch, Sophie, Thomas, Alastair, David, Beena, Lorusso, Rachel, Vochin, Ana, Penacerrada, Melchizedek, Wulandari, Retno, Heath, Charlotte, Jakkula, Srinivas, Morris, Anna, Ahmed, Ashar, Nune, Arvind, Buttriss, Claire, Whitaker, Emma, Davey, Miriam, Golden, David, Acklery, Amy, Fernandes, Fabio, Seaman, Bec, Earl, Victoria, Collins, Amy, Khaliq, Waqas, Adam, Rachel, Treus, Estefania, Holland, Sarah, Alfonso, Jordan, Blackledge, Bethan, Bruce, Michelle, Durrans, Laura Jayne, Eltayeb, Ayaa, Harris, Jade, Hey, Samuel, Hruska, Martin, Lamb, Thomas, Rothwell, Joanne, Fitzgerald, Adele, Lindergard, Gabriella, T-Michael, Helen, Duncan, Tracey, Baxter-Dore, Sharon, Cooper, Lisa, Fox, Claire, Guerin, Jacinta, Hodgkiss, Tracey, Connolly, Karen, McAlinden, Paul, Bridgett, Victoria, Fearby, Maggie, Gulati, A., Hanson, Helen, Kelly, Sinead, McCormack, Louise, Nixon, Rachel, Robinson, Philip, Slater, Victoria, Stephenson, Elaine, Webster, Andrea, Webster, K., Hays, Carole, Hudson, Anne, Patel, Bijal, Clement, Ian, Davis, John, Francis, Sarah, Jerry, Douglas, Abernathy, Caroline, Foster, Louise, Gratrix, Andrew, Cabral-Ortega, Llucia, Hines, Matthew, Martinson, Victoria, Stones, Elizabeth, Winter, Karen, Barrow, Esther, Wylie, Katharine, Baines, Deborah, Birchall, Katie, Kolakaluri, Laurel, Clark, Richard, Sukumaran, Anila, Barker, Melanie, Paripoorani, Deborah, Smith, Lara, Taylor, Charlotte, Downes, Charlotte, Hayman, Melanie, Riches, Katie, Daniel, Priya, Subramanian, Deepak, Holding, Kathleen, Hilton, Mary, Mcdonald, Carly, Richardson, Georgina, Halladay, Georgia, Harding, Peter, Reddy, Amie, Turner-Bone, Ian, Wilding, Laura, Parker, Robert, Lloyd, Michaela, Smith, Leanne, Kelly, Charlie, Lazo, Maria, Neal, Alan, Walton, Olivia, Melville, Julie, Naisbitt, Jay, Joseph, Rosane, Callam, Sara, Hudig, Lisa, Keshet-Price, Jocelyn, Stammers, Katie, Convery, Karen, Randell, Georgina, Fottrell-gould, Deirdre, Mwaura, Esther, Sutherland, Sara-Beth, Stewart, Richard, Mew, Louise, Wren, Lynn, Thrasyvoulou, Laura, Willis, Heather, Hopkins, Bridget, Lenton, Daniel, Roberts, Abigail, Bokhari, Maria, Lucas, Rachael, McCormick, Wendy, Ritzema, Jenny, Linnett, Vanessa, Sanderson, Amanda, Wild, Helen, Flanagan, Rebecca, Hull, Robert, Rhead, Kat, McKenna, Emma, Hughes, Gareth, Anderson, Jennifer, Jones, Kelly, Latham, Scott, Riley, Heather, Coulding, Martina, Clark, Martyn, McCormick, Jacqueline, Mercer, Oliver, Potla, Darsh, Rehman, Hafiz, Savill, Heather, Turner, Victoria, Jude, Edward, Kilroy, Susan, Apetri, Elena, Basikolo, Cathrine, Catlow, Laura, Collis, Matthew, Doonan, Reece, Harvey, Alice, Knowles, Karen, Lee, Stephanie, Lomas, Diane, Lyons, Chloe, McMorrow, Liam, Michael, Angiy, Pendlebury, Jessica, Perez, Jane, Poulaka, Maria, Proudfoot, Nicola, Slevin, Kathryn, Thomas, Vicky, Walker, Danielle, Dark, Paul, Charles, Bethan, McLaughlan, Danielle, Slaughter, Melanie, Horner, Dan, Marsden, Tracy, Andrews, Joyann, Beech, Emily, Akinkugbe, Olugbenga, Bamford, Alasdair, Belfield, Holly, Jones, Gareth A. L., McHugh, Tara, Meghari, Hamza, Ray, Samiran, Tomas, Ana Luisa, O’Neill, Lauran, Peters, Mark, Bell, Michael, Benkenstein, Sarah, Chisholm, Catherine, Davies, Charlene, Kupiec, Klaudia, Payne, Caroline, Halls, Joanna, Blakemore, Hayley, Goff, Elizabeth, Hayes, Kati, Smith, Kerry, Stephens, Deanna, Worner, Ruth, Borislavova, Borislava, Faulkner, Beverley, Thomas, Matt, Cookson, Ruth, Gendall, Emma, Larman, Georgina, Pope, Rebecca, Smalira, Artur, Priestley, Victoria, Cosier, Tracey, Millen, Gemma, Rand, James, Schumacher, Natasha, Sandhar, Roxana, Weston, Heather, Richardson, Neil, Cooper, Lucy, Jones, Cathy, Huang, Ya-Wen Jessica, Jacob, Reni, Denmade, Craig, Mcintyre, Lewis, Trodd, Dawn, Martin, Jane, Watson, Geoff, Bevan, Emily, Wreybrown, Caroline, Bano, Shereen, Bellwood, Ruth, Bentley, Michael, Bromley, Matt, Gurr, Lucy, Ledgard, Camilla, McGowan, Janet, Pye, Kate, Sellick, Kirsten, Stacey, Amelia, Warren, Deborah, Wilkinson, Brian, Akeroyd, Louise, Shafique, Huma, Morgan, James, Shorter, Susan, Swinger, Rachel, Waters, Emily, Lawton, Tom, Allan, Elizabeth, Darlington, Kate, Davies, Ffyon, Davies, Llinos, Easton, Jack, Kumar, Sumit, Lean, Richard, Mackay, Callum, Pugh, Richard, Qiu, Xinyi, Rees, Stephanie, Scanlon, Jeremy, Lewis, Joanne, Menzies, Daniel, Bolger, Annette, Davies, Gwyneth, Davies, Jennifer, Garrod, Esther, Jones, Helen, Manley, Rachel, Williams, Hannah, Frankham, Jordan, Pitts, Sally, White, Nigel, Branney, Debbie, Tiller, Heather, Efford, Georgia, Garland, Zoe, Grimmer, Lisa, Gumbrill, Bethany, Johnson, Rebekah, Sweet, Katie, Bewley, Jeremy, Coleman, Christina, Corcoran, Katie, Morano, Eva Maria Hernandez, Shiel, Rachel, Webster, Denise, Bonnici, Josephine, Daniel, Eleanor, Dell, Abbie, Kent, Melanie, Wilkinson, Ami, Brown, Ellen, Kay, Andrea, Campbell, Suzanne, Cowton, Amanda, Birt, Mark, Greenaway, Vicki, Potts, Kathryn, Hutton, Clare, Shepperson, Andrew, Forsey, Miranda, Nicholson, Alice, Vertue, Mark, Riches, Joanne, Kaliappan, Agilan, Nicholson, Anne, MacCallum, Niall, Raith, Eamon, Bercades, Georgia, Hass, Ingrid, Brealey, David, Martir, Gladys, Reyes, Anna, Smyth, Deborah, Zapatamartinez, Maria, Alvaro, Ana, Jetha, Champa, Ma, Louise, Booker, Lauren, Mostoles, Loreta, Pratley, Anezka, Altabaibeh, Abdelhakim, Parmar, Chetan, Gilbert, Kayleigh, Ferguson, Susie, Shepherd, Amy, Morris, Sheila, Baruah, Rosie, Lloyd, Georgina, Bell, Stephanie, Rivers, Vanessa, Purewal, Bally, Hammerton, Kate, Anderson, Susan, Birch, Janine, Collins, Emma, Oleary, Ryan, Cornell, Sarah, Jarmain, Jordan, Rogerson, Kimberley, Wakinshaw, Fiona, Woods, Lindsey, Rostron, Anthony, Elcioglu, Zeynep, Roy, Alistair, Bell, Gillian, Dickson, Holly, Wilcox, Louise, Katary, Amro, English, Katy, Hutter, Joanne, Pawley, Corinne, Doble, Patricia, Shovelton, Charmaine, Vaida, Marius, Purnell, Rebecca, Thomas, Ashly, Cagova, Lenka, Fofano, Adama, Holcombe, Helen, Mitchell, Alice Michael, Mwaura, Lucy, Praman, KrithivasanÂ, Garnr, Lucie, Mepham, Sue, Paques, Kitty, Vuylsteke, Alain, Mackie, Jennifer, Pearn, Carmen, Zamikula, Julie, Nyirenda, Maggie, Capozzi, Lisa, Reece-Anthony, Rosie, Noor, Hazma, Nilo, Alfa Cresia, Grove, Michelle, Daniel, Amelia, Finn, Joanne, White, Nikki, Saha, Rajnish, Badal, Bibi, Ixer, Karen, Duffin, Donna, Player, Ben, Hill, Helen, Cole, Jade, Brooks, Jenny, Davies, Rhys, Hunt, Lauren, Thomas, Emma, Williams, Angharad, Oblak, Metod, Thankachen, Mini, Irisari, Jamie, Sayan, Amrinder, Popescu, Monica, Finch, Cheryl, Jamieson, Andrew, Quinn, Alison, Cooper, Joshua, Liderth, Sarah, Waddington, Natalia, Burn, Iona, Manso, Katarina, Penn, Ruth, Tebbutt, Julie, Thornton, Danielle, Winchester, James, Hambrook, Geraldine, Shanmugasundaram, Pradeep, Craig, Jayne, Simpson, Kerry, Higham, Andrew, Sibbett, Louise, Paine, Sheila, Reed, Annabel, Conyngham, Jo-Anna, Mupudzi, Mcdonald, Thomas, Rachel, Wright, Mary, Griffin, Denise, Partridge, Richard, Corral, Maria Alvarez, Muchenje, Nycola, Sitonik, Mildred, Butler, Aaron, Folkes, Linda, Fox, Heather, Gardner, Amy, Helm, David, Hobden, Gillian, King, Kirsten, Margalef, Jordi, Margarson, Michael, Martindale, Tim, Meadows, Emma, Raynard, Dana, Thirlwall, Yvette, Baird, Yolanda, Gomez, Raquel, Martin, Darren, Hodgson, Luke, Corin, Clinton, Sidall, Erikka, Szabo, Densie, Floyd, Sharon, Davies, Hannah, Austin, Karen, Kelsall, Olivia, Wood, Hannah, Cornell, Thomas, Ralph, Kate, Bean, Sarah, Burt, Karen, Spivey, Michael, Richards, Carol, Tedstone, Rachel, Carmody, Siobhain, Zhao, Xiaobei, Page, Valerie, Guanco, Mark Louie, Hoxha, Elvira, Zorloni, Camilla, Dean, Charlotte, Jones, Emma, Carter, Emma, Dunn, Joshua, Kong, Thomas, Mahenthran, Mervin, Marsh, Chris, Holland, Maureen, Keenan, Natalie, Mahmoud, Mohamed, Lyons, Marc, Wassall, Helen, Young, Meghan, Bradley, Paul, Burda, Dorota, Donlon, Sinead, Harden, Lesley, Harris, Celia, Mayangao, Irving, Montaser, Rugia, Mtuwa, Sheila, Piercy, Charles, Smith, Eleanor, Stone, Sarah, Verula, Jerik, Blackman, Helen, Marriott, Cheryl, Michalak, Natalia, Creagh-Brown, Ben, Salberg, Armorel, Boyer, Naomi, Pristopan, Veronika, Maynard, Victoria, Walker, Rachel, Hormis, Anil, Collier, Dawn, Graham, Cheryl, McCormick, Jake, Warrington, Jake, Cosgrove, Denise, McFarland, Denise, Ratcliffe, Judith, Charnock, Rob, Wynter, Inez, Gill, Mandy, Kirk, Jill, Paul, Paul, Ratnam, Valli, Shelton, Sarah, Jardine, Catherine, Hay, Alasdair, Williams, Dewi, Durga, Latha, Hibbert, Meg, Kennard-Holden, Gareth, Woodford, Chrsitopher, Tetla, Dariusz, Price, Alicia, Thomas, Alice, Thorpe, Chris, Knights, Ellen, Ward, Donna, Laha, Shondipon, Verlander, Mark, Williams, Alexandra, Prout, Rachel, Langton, Helen, Watters, Malcolm, Hunt, Charlotte, Novis, Catherine, Arif, Sarwat, Cunningham, Amy, Hewitt, Claire, Hindale, Julia, Jackson-Lawrence, Karen, Shepardson, Sarah, Wills, Maryanne, Butler, Susie, Tavares, Silivia, Barber, Russell, Hilldrith, Annette, Hubbard, Kelly, Egginton, Dawn, Clark, Michele, Purvis, Sarah, Sinclair, Simon, Collins, Vicky, Landeg, Bethan, Sell, Craig, Coetzee, Samantha, Gales, Alistair, Otahal, Igor, Icke, Becky, Raj, Meena, Williams, Caroline, Williams, Jill, Hill, Lucy, Kayani, Abdul, Masunda, Bridgett, Gondo, Prisca, Atayeva, Nigara, Cruz, Carina, Pattison, Natalie, Burnett, Caroline, Hatton, Jonathan, Heeney, Elaine, Newton, Maria, Al-Moasseb, Hassan, Behan, Teresa, Player, Jasmine, Stead, Rachael, Mitra, Atideb, Nauyokas, Kirsty, Humphreys, Sally, Cockerill, Helen, Tampsett, Ruth, Postovalova, Evgeniya, Coventry, Tina, McGregor, Amanda, Fowler, Susan, Macmahon, Mike, Cochrane, Patricia, Pirie, Sandra, Hanley, Sarah, Ali, Asifa, Brady, Megan, Dale, Sam, Dance, Annalisa, Gledhill, Lisa, Greig, Jill, Hanson, Kathryn, Holdroyd, Kelly, Home, Marie, Ishaq, Tahira, Kelly, Diane, Matapure, Lear, Melia, Deborah, Mellor, Samantha, Merwaha, Ekta, Nortcliffe, Tonicha, Shaw, Lisa, Shaw, Ryan, Wood, Tracy, Bayo, Lee-Ann, Usher, Miranda, Wilson, Alison, Kitson, Ross, Pinnell, Jez, Robinson, Matthew, Boltwood, Kaitlin, Birch, Jenny, Bough, Laura, Tutton, Rebecca, Winter-Goodwin, Barbara, Goodsell, Josie, Taylor, Kate, Williams, Patricia, Williams, Sarah, Cave, Ashleigh, Rees, James, Imeson-Wood, Janet, Smith, Jacqueline, Amin, Vishal, Karthik, Komala, Kausar, Rizwana, Anastasescu, Elena, Reid, Karen, Anumakonda, Vikram, Stoddart, Ella, Demetriou, Carrie, Eckbad, Charlotte, Howie, Lucy, Mitchard, Sarah, Ramos, Lidia, White, Katie, Hierons, Sarah, Kelly, Fiona, Serrano-Ruiz, Alfredo, Evans, Gabrielle, Nicol, Liz, Wilkins, Joy, Hulacka, Kim, Debreceni, Gabor, Brown, Alison, Crickmore, Vikki, Hill, Kay, Kannan, Thogulava, Dagutao, Zenaida, Beesley, Kate, Lewis, Alison, Perry, Jess, Antony, Sherly, Board, Sarah, Buckley, Clare, Pippard, Lucy, Tanate, Alfonso, Wood, Diane, Kubisz-Pudelko, Agnieska, Gouda, Ayman, Auld, Fiona, Donnachie, Joanne, Murdoch, Euan, Prentice, Lynn, Runciman, Nikole, Senaratne, Dhaneesha, Short, Abigail, Sweeney, Laura, Symon, Lesley, Todd, Anne, Turner, Patricia, McCann, Erin, Salutous, Dario, Edmond, Ian, Whitelaw, Lesley, Bland, Yvonne, Kajtor, Istvan, Kavanagh, Lisa, Singler, Karen, Linfield-Brown, George, Moore, Luke Stephen Prockter, Vizcaychipi, Marcela, Martins, Laura, Moore, Luke, Bull, Rhian, Carungcong, Jaime, Allen, Louise, Beranova, Eva, Knight, Alicia, Price, Carly, Tilbey, Sorrell, Turney, Sharon, Hazelton, Tracy, Tutt, Gabriella, Arora, Mansi, Turki, Salah, Sinfield, Emily, Deery, Joanne, Ramos, Hazel, Cristiano, Daniele, Dormand, Natalie, Farzad, Zohreh, Gummadi, Mahitha, Salmi, Sara, Sloane, Geraldine, Varghese, Mathew, Thwaites, Vicky, Patel, Brijesh, Kamal, Liyanage, Zborowski, Anelise Catelan, Coe, Ryan, Anderson, Madeleine, Beadle, Jane, Coates, Charlotte, Collins, Katy, Crowley, Maria, Johnson, Laura, King, Laura, Paramsothy, Remi, Sargeant, Janet, Silva, Pedro, Stuart, Carmel, Taylor, June, Tyl, David, Wakefield, Phillipa, Kamundi, Charlotte, Olufuwa, Olumide, Belagodu, Zakaulla, Gherman, Anca, Oakley, Naomi, Allan, John, Geary, Tim, Meikle, Alistair, O’Brien, Peter, Wood, Stephen, Clark, Andrew, Houston, Gordon, Black, Karen, Clarkson, Michelle, D’Sylva, Stuart, Morrison, Alan, Norman, Kathryn, Taylor, Margaret, Clements, Suzanne, Cohrane, Catriona, Gonzalez, Nora, Strachan, Dominic, Beith, Claire, Moar, Kirsten, Anderson, Peter, Archer, Katie, Burtenshaw, Andrew, Clayton, Sarah, Cother, Naiara, Cowley, Nicholas, Davis, Caroline, Digby, Stephen, Durie, Alison, Harrison, Alison, Low, Emma, McAlindon, Michael, McCurdy, Alex, Morgan, Aled, Rankin, Tobias, Thrush, Jessica, Tranter, Helen, Vigurs, Charlie, Wild, Laura, Murphy, Lorna, Smythe, Michelle, Brickell, Kathy, Ali, Inthakab Ali Mohamed, Beaumont, Karen, Elsaadany, Mohamed, Fernandes, Kay, Ally, Sameena Mohamed, Rangarajan, Harini, Sarathy, Varun, Selvanayagam, Sivarupan, Vedage, Dave, White, Matthew, Coton, Zoe, Joshy, Aricsa, Blunt, Mark, Curgenven, Hollie, Botfield, Liam, Dexter, Catherine, Kuravi, Aditya, Butler, Joanne, Chadwick, Robert, Ranga, Poonam, Richardson, Lisa, Virgilio, Emma, Anwer, Maddiha, Garg, Atul, Botfield, Donna, Marriott, Xana, Stewart, Keely, Mullan, Dee, Gaylard, Jane, Nowak, Justyna, Jones, Sian, Crawley, Rikki, Crew, Abigail, Cunningham, Mishell, Daniels, Allison, Harrison, Laura, Hope, Susan, Lancaster, Nicola, Matthews, Jamie, Wray, Gemma, Inweregbu, Ken, Cutts, Sarah, Miller, Katharine, Brady, Ailbhe, Chan, Rebekah, McIvor, Shane, Prady, Helena, Mathew, Bijoy, Little, Jeff, Furniss, Tim, Wright, Chris, King, Bernadette, Wasson, Christopher, O’Neill, Aisling, Turley, Christine, McGuigan, Peter, Collins, Erin, Finn, Stephanie, Green, Jackie, McAuley, Julie, Nair, Abitha, Quinn, Charlotte, Tauro, Suzanne, Ward, Kathryn, McGinlay, Michael, Reddy, Kiran, Ahmad, Norfaizan, Anderson, Samantha, Barker, Joann, Bauchmuller, Kris, Birchall, Kathryn, Bird, Sarah, Cawthron, Kay, Chetam, Luke, Cole, Joby, Donne, Ben, Foote, David, Ford, Amber, Hanratty, Helena, Harrington, Kate, Hesseldon, Lisa, Housley, Kay, Jackson, Yvonne, Jarman, Claire, Kibutu, Faith, Lenagh, Becky, Macharia, Irene, Masuko, Shamiso, Milner, Leanne, Newell, Helen, Nwafor, Lorenza, Oxspring, Simon, Phillips, Patrick, Raithatha, Ajay, Rowland-Jones, Sarah, Smith, Jacqui, Thompson, Roger, Trower, Helen, Walker, Sara, Watson, James, Wiles, Matthew, Lye, Alison, Willson, Jayne, Mills, Gary, Harris, Sansha, Hartill, Eleanor, Barron, Anthony, Collins, Ciara, Kaul, Sundeep, Nolan, Claire, Polgar, Oliver, Prendergast, Claire, Rogers, Paula, Shokkar, Rajvinder, Woodruff, Meriel, Mahay, Kanta, Reed, Anna, Meyrick, Hayley, Passmore, Heather, Farwell, James, O’Connell, Susan, Gregory, Jane, Barberis, Luigi, Harper, Rosemary, Smith, Tim, Armstrong, Diane, Bowey, Angie, Cowley, Anne, Corner, Andrew, Highgate, Judith, Rutherfurd, Claire, Taylor, Jo-Anne, Goodwin, Sarah, Eapen, Beena, Trim, Fiona, Donnison, Phil, Armstrong, Lisa, Bates, Hayley, Dooks, Emma, Farquhar, Fiona, Kitching, Amy, McParland, Chantal, Packham, Sophie, Hairsine, Brigid, Andreou, Premetie, Hales, Dawn, Mathews, Megha, Patel, Rekha, Barry, Peter, Flint, Neil, Hailstone, Jessica, Ghuman, Navneet, Leonard, Bethany, Lees, Rachel, Butcher, Deborah, Leng, Katy, Butterworth-Cowin, Nicola, O’Sullivan, Susie, Ghosh, Alison, Williams, Emma, Adams, Colene, Agasou, Anita, Arden, Tracie, Beekes, Mandy, Bowes, Amy, Boyle, Pauline, Button, Heather, Carnahan, Mandy, Carter, Anne, Childs, Danielle, Hurford, Fran, Hussain, Yasmin, Javaid, Ayesha, Jones, James, Leigh, Michael, Martin, Terry, Millward, Helen, Motherwell, Nichola, Newman, Julie, Rikunenko, Rachel, Stickley, Jo, Summers, Julie, Ting, Louise, Tivenan, Helen, Donaldson, Denise, Capps, Nigel, Cale, Emily, Jose, Sanal, Osbourne, Wendy, Pajak, Susie, Rankin, Jayne, Tonks, Louise, Baird, Tracy, Harkins, Margaret, Ruddy, Jim, West, Joe, Duffield, Joseph, Mallon, Lewis, Smith, Oliver, Smuts, Sara, Campbell, Andy, Davies, Cate, Davies, Sarah, Hughes, Rachel, Jobes, Lisa, Whitehead, Victoria, Watkins, Clare, Bowman, Fiona, Milligan, Barry, McPherson, Liane, Metherell, Stella, Harris, Nichola, Lake, Victoria, Radford, Elizabeth, Smallwood, Andy, Gopal, Shameer, Vassell, Katherine, Bell, Dina, Boyle, Rosalind, Douglas, Katie, Glass, Lynn, Lennon, Liz, Rattray, Austin, Lee, Emma, Jones, Danielle, Parsons, Penny, Attwood, Ben, Jefferson, Paul, Ranganathan, Mohan, Atwal, Inderjit, Campbell, Bridget, Day, Angela, Stagg, Camilla, Haynes, Emma, Ahmed, Cecilia, Clamp, Sarah, Colley, Julie, Haq, Risna, Hayes, Anne, Joseph, Sibet, Maqsood, Zahira, Hussain, Samia, Hulme, Jonathan, Domingos, Patience, Kumar, Rita, Purewal, Manjit, Taylor, Becky, Bunni, Lara, Latif, Monica, Jennings, Claire, Jose, Shilu, Marshall, Rebecca, Metryka, Aleksandra, Subramanian, Gayathri, Burgoyne, Adam, Tyler, Amanda, Waldron, Joanne, Hilltout, Paula, Evitts, Jayne, Ward, Geraldine, Bremmer, Pamela, Hawkins, Carl, Jackman, Sophie, Ogorek, Michal, Ashby, Kylie, Thornton, Lorraine, Mercer, Pauline, Halkes, Matthew, Revill, Adam, Saint, Bryony, Fletcher, Jo, Netherton, Kimberley, Chablani, Manish, Kirkby, Amy, Roper, Amanda, Szymiczek, Kinga, Sutherland, Isobel, O’Brien, Linda, Connell, Joanne, Davies, Kim, Lewis, Tracy, Omar, Zohra, Perkins, Emma, Sathe, Sonia, Davies, Ellie, Lyon, Alex, Mapfunde, Isheunesu, Willis, Charlotte, Hitchcock, Rachael, Hall, Kathryn, King, Christopher, Fagan, Andrew, Nazari, Roonak, Worsley, Lucy, Allibone, Suzanne, Kasipandian, Vidya, Patel, Amit, Cutting, Parisa, Genetu, Roman, Mac, Ainhi, Murphy, Anthony, Ward, Sinead, Butt, Fatima, Ayers, Amanda, Harrison, Wendy, Mackintosh, Katherine, North, Julie, Ashton, Lydia, Bi, Rehana, Owen, Samantha, Winmill, Helen, Scholefield, Barney, Blowing, Hannah, Williams, Erin, Duskova, Michaela, Edwards, Michelle, Rees, Alun, Thomas, Helen, Brooks, Jolene, Phipps, Janet, Brooks, Suzanne, Dennis, Catherine, Parris, Vicki, Srikaran, Sinduya, Sukha, Anisha, McGregor, Alistair, Tiongson, Gerlynn, Adams, Katie, Andrew, Benedict, Brayne, Adam, Carter, Sasha, Findlay, Louise, Fisher, Emma, Jackson, Peter, Kaye, Duncan, Parkin, Juliet, Tuckey, Victoria, Hunt, Jane, Love, Nicholas, van Koutrick, Lynne, Hanson, Ashley, Dent, Kathy, Horsley, Elizabeth, Pearson, Sandra, Spencer, Sue, Hutchinson, Dorothy, Potoczna, Dorota, Akhtar, Muhammad Nauman, Cottam, Lisa-Jayne, Sanders, Jack, Garcia, Sara Mingo, pakou, Glykeria, Filipe, Helder, Maharajh, Amitaa, de Neef, Mark, Martin, Daniel, Eastgate, Christine, Teoh, Poh Choo, Barrett, Fiona, Bradley, Clare, Donaldson, Avril, Mascarenhas, Mairi, O’Hara, Marianne, Okeefe, Laura, Clarke, Noreen, Whiteside, Jonathan, Campbell, Rachael, Matheson, Joanna, McDonald, Deborah, Patience, Donna, Rice, Polly, Clapham, Melanie, Mutch, Rachel, Craig, Hannah, Poultney, Una, Burns, Karen, Twiss, Sophie, Barton, Janet, George, Linsha, Harrop, Clare, Mathew, Sherly, Wright, David Justin, Harrison, Rachel, Toohie, Jordan, Chandler, Ben, Turnbull, Alison, Mallinson, Janine, Elliott, Kerry, Wolf-Roberts, Rebecca, Tench, Helen, Hobrok, Maria, Loosley, Ronda, McGuinness, Heather, Sims, Tanya, Afolabi, Deborah, Allison, Kathryn Sian, Anderson, Taya, Dore, Rachael, Jones, Dawn, Rogers, Naomi, Saunderson, Paula, Whitbread, Jennifer, O’Malley, Laura, Rad, Laura, Hawcutt, Daniel, Aldridge, Jonathan, Tolson, Melanie, Garrioch, Sweyn, Tomlinson, Joanne, Grosdenier, Michael, Loader, David, Kapoor, Ritoo, Hector, Gemma, Scherewode, Joslan, Sri-Chandana, Chunda, Stephenson, Lorraine, Marsh, Sarah, Rosa, Arnold Dela, Jhanji, Shaman, Bemand, Thomas, Howle, Ryan, Baikady, Ravishankar Rao, Thomas, Benjamin, Black, Ethel, Tatham, Kate, Gurram, Sambasivarao, Watson, Ekaterina, Quaid, Sheena, Saunderson, Anne, O’Brien, Rachel, Moultrie, Sam, Service, Jen, Cheyne, Clare, Odam, Miranda, Wiliams, Alison, Barnes, Nicky, Csabi, Peter, Rocha, Joana Da, Glynou, Louika, Huffenberger, Amy, Bryant, Jade, Pickard, Amy, Roe, Nicholas, Bellini, Arianna, Mayer, Anton, Burrow, Amy, Colley, Natalie, Evans, Jayne, Howlett, Alex, Khalifeh, Zeinab, Pryce, Jerldine, Gorman, Claire, Brady, Rebecca, Timlick, Elizabeth, Antoine, Pierre, Gupta, Abhinhav, Hardy, John, Houlden, Henry, Moncur, Eleanor, Tucci, Arianna, Tariq, Ambreen, Tagliavini, Emma, Ramsay, Becky, Fidler, Katy, Donnelly, Kevin, Hollis, Rebecca, Barr, Jocelyn, Boyd, Elizabeth, Irvine, Val, Shelley, Ben, Buckley, Julie, Hamilton, Charlene, Valdeavella, Kathryn, Bircham, Sarah, Liggett, Steven, Patil, Anand, Siddiq, Afshan, Goddard, Peter, Donovan, Sally, Zainy, Tala, Maleady-Crowe, Fiona, Todd, Linda, Salehi, Shahla, Elgar, Greg, Chan, Georgia, Arumugam, Prabhu, Patch, Christine, Rendon, Augusto, Bentley, David, Kingsley, Clare, Fowler, Tom A., Elliott, Paul, Tenesa, Albert, Aitkin, Emma, Aravindan, Latha, Armstrong, Ruth, Biggs, Heather, Boz, Ceilia, Brown, Adam, Chikowore, Primmy, Coutts, Audrey, Coyle, Judy, Cullum, Louise, Das, Sukamal, Day, Nicky, Donnelly, Lorna, Duncan, Esther, Finernan, Paul, Fourman, Max Head, Furlong, Anita, Furniss, James, Gallagher, Bernadette, Gilchrist, Tammy, Golightly, Ailsa, Hafezi, Katarzyna, Hamilton, Debbie, Hendry, Ross, Kearns, Naomi, Law, Dawn, Law, Rachel, Law, Sarah, Lidstone-Scott, Rebecca, Lauder, Christen, Macgillivray, Louise, Maclean, Alan, Mal, Hanning, McCafferty, Sarah, Mcmaster, Ellie, Meikle, Jen, Moore, Shona C., Murphy, Sheena, Mybaya, Hellen, Oosthuyzen, Wilna, Zheng, Chenqing, Chen, Jiantao, Paterson, Trevor, Tucker, Petra, Schon, Katherine, Stenhouse, Andrew, Das, Mihaela, Swets, Maaike, Szoor-McElhinney, Helen, Taneski, Filip, Turtle, Lance, Wackett, Tony, Ward, Mairi, Weaver, Jane, Wrobel, Nicola, Rakitko, Alexander, Ilinsky, Valery, Yermakovich, Danat, Popov, Iaroslav, Chernitsov, Alexander, Kovalenko, Elena, Vergasova, Ekaterina, Prokhorov, Alexandr, Krasnenko, Anna, Plotnikov, Nikolay, Stetsenko, Ivan, Kim, Anna, Cirulli, Elizabeth T., Schiabor Barrett, Kelly M., Bolze, Alexandre, White, Simon, Washington, Nicole L., Lu, James T., Riffle, Stephen, Tanudjaja, Francisco, Wang, Xueqing, Ramirez, Jimmy M., Leonetti, Nicole, Sandoval, Efren, Neveux, Iva, Dabe, Shaun, Grzymski, Joseph J., Joshi, Madhvi N., Dixit, Raghav D., Shah, Pranay K., Upadhyay, Kamlesh J., Chuhan, Naresh T., Desai, Kairavi J., Shah, Meenakshi R., Modi, Bhavesh, Joshi, Chaitanya G., Pandit, Ramesh J., Singh, Indra, Ansari, Afzal I., Raval, Janvi N., Patel, Zarna Z., Moreno-Estrada, Andres, Vázquez-Pérez, Joel Armando, Castillejos-López, Manuel, Aquino-Gálvez, Arnoldo, Shamah-Levy, Teresa, Ávila-Arcos, María C., Luna, María Teresa Tusié, Hidalgo-Miranda, Alfredo, Barberena-Jonas, Carmina, Quinto-Cortés, Consuelo D., Ávila-Arcos, Marco Antonio, Huerta-Chagoya, Alicia, García-García, Lourdes, Barnetche, Jesús Martinez, Alpuche-Aranda, Celia, Rivera, Juan A., Gutiérrez, Tonatiuh Barrientos, Ochoa-Guzmán, Ana, Ordoñez-Sánchez, Maria Luisa, Segura-Kato, Yayoi, Herrera-Montalvo, Luis Alonso, Mendoza-Vargas, Alfredo, Reyes-Grajeda, Juan Pablo, Cruz-Cruz, Alonso D., Velázquez-Cruz, Rafael, Torres-Espíndola, Luz María, Sierra-Vargas, Martha Patricia, Camarena, Angel, Ruiz, Víctor, Chávez-Alderete, Jaime, Jaime-Capetillo, María Esther, Guadarrama-Pérez, Cristóbal, Zúñiga-Ramos, Joaquin, Olivera-Ramírez, Alejandra, Martínez, Miguel Angel López, Serna-Muñoz, Ricardo, Garmendia, Adriana, Namkoong, Ho, Okada, Yukinori, Imoto, Seiya, Katayama, Kazuhiko, Fukunaga, Koichi, Kitagawa, Yuko, Sato, Toshiro, Hasegawa, Naoki, Kumanogoh, Atsushi, Kimura, Akinori, Ai, Masumi, Tokunaga, Katsushi, Kanai, Takanori, Miyano, Satoru, Ogawa, Seishi, Edahiro, Ryuya, Sonehara, Kyuto, Shirai, Yuya, Ishii, Makoto, Kabata, Hiroki, Masaki, Katsunori, Kamata, Hirofumi, Ikemura, Shinnosuke, Chubachi, Shotaro, Okamori, Satoshi, Terai, Hideki, Tanaka, Hiromu, Morita, Atsuho, Lee, Ho, Asakura, Takanori, Sasaki, Junichi, Morisaki, Hiroshi, Uwamino, Yoshifumi, Nanki, Kosaku, Mikami, Yohei, Tomono, Kazunori, Kato, Kazuto, Matsuda, Fumihiko, Takahashi, Meiko, Hizawa, Nobuyuki, Takeda, Yoshito, Hirata, Haruhiko, Shiroyama, Takayuki, Miyawaki, Satoru, Suzuki, Ken, Maeda, Yuichi, Nii, Takuro, Noda, Yoshimi, Niitsu, Takayuki, Adachi, Yuichi, Enomoto, Takatoshi, Amiya, Saori, Hara, Reina, Takahashi, Kunihiko, Anzai, Tatsuhiko, Hasegawa, Takanori, Ito, Satoshi, Koike, Ryuji, Endo, Akifumi, Uchimura, Yuji, Miyazaki, Yasunari, Honda, Takayuki, Tateishi, Tomoya, Tohda, Shuji, Ichimura, Naoya, Sonobe, Kazunari, Sassa, Chihiro, Nakajima, Jun, Nannya, Yasuhito, Omae, Yosuke, Takahashi, Kazuhisa, Harada, Norihiro, Hiki, Makoto, Takagi, Haruhi, Nakamura, Ai, Tagaya, Etsuko, Kawana, Masatoshi, Arimura, Ken, Ishiguro, Takashi, Takayanagi, Noboru, Isono, Taisuke, Takaku, Yotaro, Takano, Kenji, Anan, Ryusuke, Nakajima, Yukiko, Nakano, Yasushi, Nishio, Kazumi, Ueda, Soichiro, Hayashi, Reina, Tateno, Hiroki, Hase, Isano, Yoshida, Shuichi, Suzuki, Shoji, Mitamura, Keiko, Saito, Fumitake, Ueda, Tetsuya, Azuma, Masanori, Nagasaki, Tadao, Yasui, Yoshinori, Hasegawa, Yoshinori, Mutoh, Yoshikazu, Yoshiyama, Takashi, Shoko, Tomohisa, Kojima, Mitsuaki, Adachi, Tomohiro, Ishikawa, Motonao, Takahashi, Kenichiro, Watanabe, Kazuyoshi, Manabe, Tadashi, Ito, Fumimaro, Fukui, Takahiro, Funatsu, Yohei, Koh, Hidefumi, Hirai, Yoshihiro, Kawashima, Hidetoshi, Narita, Atsuya, Niwa, Kazuki, Sekikawa, Yoshiyuki, Saito, Fukuki, Yoshiya, Kazuhisa, Yoshihara, Tomoyuki, Suzuki, Yusuke, Nakayama, Sohei, Masuzawa, Keita, Nishi, Koichi, Nishitsuji, Masaru, Tani, Maiko, Inoue, Takashi, Hirano, Toshiyuki, Kobayashi, Keigo, Miyazawa, Naoki, Kimura, Yasuhiro, Sado, Reiko, Ogura, Takashi, Kitamura, Hideya, Murohashi, Kota, Nakachi, Ichiro, Baba, Rie, Arai, Daisuke, Fuke, Satoshi, Saito, Hiroshi, Kuwahara, Naota, Fujiwara, Akiko, Okada, Takenori, Baba, Tomoya, Noda, Junya, Mashimo, Shuko, Yagi, Kazuma, Shiomi, Tetsuya, Hashiguchi, Mizuha, Odani, Toshio, Mochimaru, Takao, Oyamada, Yoshitaka, Mori, Nobuaki, Izumi, Namiki, Nagata, Kaoru, Taki, Reiko, Murakami, Koji, Yamada, Mitsuhiro, Sugiura, Hisatoshi, Hayashi, Kentaro, Shimizu, Tetsuo, Gon, Yasuhiro, Fujitani, Shigeki, Tsuchida, Tomoya, Yoshida, Toru, Kagaya, Takashi, Kita, Toshiyuki, Sakagami, Satoru, Kimizuka, Yoshifumi, Kawana, Akihiko, Nakamura, Yoshihiko, Ishikura, Hiroyasu, Takata, Tohru, Kikuchi, Takahide, Taniyama, Daisuke, Nakamura, Morio, Kodama, Nobuhiro, Kaneyama, Yasunari, Maeda, Shunsuke, Nagasaki, Yoji, Okamoto, Masaki, Ishihara, Sayoko, Ito, Akihiro, Chihara, Yusuke, Takeuchi, Mayumi, Onoi, Keisuke, Hashimoto, Naozumi, Wakahara, Keiko, Ando, Akira, Masuda, Makoto, Wakabayashi, Aya, Watanabe, Hiroki, Sageshima, Hisako, Nakada, Taka-Aki, Abe, Ryuzo, Shimada, Tadanaga, Kawamura, Kodai, Ichikado, Kazuya, Nishiyama, Kenta, Yamasaki, Masaki, Hashimoto, Satoru, Kusaka, Yu, Ohba, Takehiko, Isogai, Susumu, Takada, Minoru, Kanda, Hidenori, Komase, Yuko, Sano, Fumiaki, Asano, Koichiro, Oguma, Tsuyoshi, Harada, Masahiro, Takahashi, Takeshi, Shibusawa, Takayuki, Abe, Shinji, Kono, Yuta, Togashi, Yuki, Izumo, Takehiro, Inomata, Minoru, Awano, Nobuyasu, Ogawa, Shinichi, Ogata, Tomouki, Ishihara, Shoichiro, Kanehiro, Arihiko, Ozaki, Shinji, Fuchimoto, Yasuko, Kitagawa, Yuichiro, Yoshida, Shozo, Ogura, Shinji, Nishiyama, Kei, Yoshida, Kousuke, Beppu, Satoru, Fukuyama, Satoru, Eriguchi, Yoshihiro, Yonekawa, Akiko, Inoue, Yoshiaki, Yamagata, Kunihiro, Chiba, Shigeru, Narumoto, Osamu, Nagai, Hideaki, Ooshima, Nobuharu, Motegi, Mitsuru, Sagara, Hironori, Tanaka, Akihiko, Ohta, Shin, Shibata, Yoko, Tanino, Yoshinori, Sato, Yuki, Yamada, Yuichiro, Hashino, Takuya, Shinoki, Masato, Iwagoe, Hajime, Imamura, Tomonori, Umeda, Akira, Shimada, Hisato, Endo, Mayu, Hayashi, Shinichi, Takahashi, Mai, Nakano, Shigefumi, Yatomi, Masakiyo, Maeno, Toshitaka, Ishii, Tomoo, Utsugi, Mitsuyoshi, Ono, Akihiro, Kanaoka, Kensuke, Ihara, Shoichi, Komuta, Kiyoshi, Nishida, Nao, Kawai, Yosuke, Sugiyama, Masaya, Alawneh, Laith M., Maswadeh, Kinda B., Alsoub, Fatima S., AlRawashdeh, Tala J., Esawi, Ezaldeen, Abu Alragheb, Bayan O., Maswadeh, Ahmad B., Al-Kadash, Abdulfattah, Al-Ani, Abdallah, Alsafadi, Dana B., Shahin, Mohammad A., Qtaish, Nuseibah Al, Alawneh, Fade M., Abulail, Joseph A., Zhlawi, Hadi J., Alhousani, Tasneem N., Alzuraiqi, Mohammad R., Al-Ja’afreh, Mohammad M., Allouzy, Sara K., ALjalamdeh, Mothafer, Mansour, Tareq M., Alamer, Lina M., Issa, Ali Banni, Bani younis, Fatima M., Hawari, Feras I., Hayajneh, Wail A., Obeidat, Nathir M., Ahram, Mamoun, Zhlawi, Moh’d Wahib J., Alshaer, Walhan, Al-Kasasbeh, Malak M., Naffa, Randa G., Ismail, Mohammad A., Abdullah, Mohammed S., Ismail, Said I., Obeidat, Ma’en, Hernández Cordero, Ana I., Sin, Don D., Bossé, Yohan, Joubert, Philippe, Hao, Ke, Nickle, David, Timens, Wim, van den Berge, Maarten, Feng, Yen-Chen Anne, Mercader, Josep, Weiss, Scott T., Karlson, Elizabeth W., Smoller, Jordan W., Murphy, Shawn N., Meigs, James B., Woolley, Ann E., Green, Robert C., Mandla, Ravi, Schroeder, Philip, Perez, Emma F., Lee, Seung Hyuk T., Flores-Silva, Fernando Daniel, Chiquete, Erwin, Cantú-Brito, Carlos, Sifuentes-Osornio, José, de León-Garduño, Alfredo Ponce, Román-Montes, Carla Marina, Chávez-Manzanera, Emma, Velasco, Donaji Gómez, Martagón-Rosado, Alexandro, Cruz-Bautista, Ivette, Gómez-Pérez, Francisco Javier, Díaz-Olavarrieta, Claudia, Valdés, Paloma Almeda, Muñóz-Hernández, Linda Liliana, Mehta, Roopa Pravin, Elías-López, Daniel, Tusié-Luna, Teresa, Pajukanta, Päivi, Sukhatme, Mihir G., Moreno-Macías, Hortensia, Ruth, Johnson, González-Behn-Eschenburg, Sebastián, García-Grimshaw, Miguel, Guillen-Pineda, Luz Elizabeth, de los Ángeles Vargas-Martínez, María, Rodríguez, Maribel, Rodríguez-Guillén, Rosario, Ordoñez, María Luisa, Rajme-López, Sandra, González-Lara, María Fernanda, Luna-Moreno, Dalia, de Jesús Suárez López, Jannet, Guillén-Quintero, Daniela Mariel, Vega, Juan, Duran-Coyote, Salvador, Guerra-García, María Teresa, Durán-Gómez, Michelle, Vigueras-Hernández, Alma, Ramírez-Jiménez, Marco Eduardo, Grajeda-González, Samara Lissete, Ramos-Galicia, Enrique Manuel, Ramírez-Carrillo, Martha Fernanda, Fernandez-Ruiz, Juan, Chirino-Pérez, Amanda, Romero-Molina, Ángel Omar, Zavaleta, David Alejandro Fuentes, Jaramillo, María Andrea Mac Donald, López, Katia Jarely Prieto, Incontri-Abraham, Diego, Rosado, Wendy Natalia, Catalán, María Alonso, Aguilar, Sonia Evelyn Vital, Zamudio, Ileana Paola Montero, Ruíz-Ruíz, Eduardo, de Jesús Carrera García, Kevin, Guerrero, Cristina Villarreal, Martínez, Ana Isabel Rodríguez, Moscoso-Sánchez, Rogelio, del Consuelo Rodríguez Mancilla, María, Villa, Antonio, Luna-Ramírez, Samuel Alejandro, Hernández-Hernández, Sergio, Frias, Erika, Campos, Alejandro, Morales-Sosa, Paola Alessandra, Toxqui-Merchant, Luis Enrique, García, Karla, Pasaniuc, Bogdan, Butte, Manish J., Geschwind, Daniel H., Aguilar-Salinas, Carlos A., Heidecker, Bettina, Kurth, Florian, Sander, Leif E., Skurk, Carsten, Landmesser, Ulf, Karadeniz, Zehra, Wang, Xiaomin, Poller, Wolfgang, Suwalski, Phillip, Ripke, Stephan, Braun, Alice, Kraft, Julia, Mayer, Alena, Lippert, Lena J., Helbig, Elisa T., Thibeault, Charlotte, Awasthi, Swapnil, Mbarek, Hamdi, Saad, Chadi, Al-Sarraj, Yaser, Badji, Radja Messai, Al-Muftah, Wadha, Thani, Asma Al, Afifi, Nahla, Sadiq, Fouzia, Khan, Mohammad I., Bhutta, Muhammad J., Khan, Hania, Khan, Madeeha, Ain, Quratul, Junaid, Ayesha, Khan, Ejaz A., Sypniewski, Mateusz, Lejman, Adrian, Zawadzki, Paweł, Sztromwasser, Paweł, Król, Zbigniew, Dobosz, Paula, Stojak, Joanna, Flores, Carlos, Carracedo, Ángel, Aguilar, Carlos, Arranz, María J., Baptista-Rosas, Raúl C., Bezerra, Joao F., Bezerra, Marcos A. C., Brugada, Ramón, Bustos, Matilde, Castano, Luis, Conde-Vicente, Rosa, Cordero-Lorenzana, M. Lourdes, De Martino-Rodríguez, Alba, Domínguez-Garrido, Elena, Fariñas, María Carmen, Gil-Fournier, Belén, Herrero, María José, Lattig, María Claudia, Martín-López, Caridad, Martín, Vicente, Martinez-Nieto, Oscar, Martinez-Lopez, Iciar, Mazzeu, Juliana F., Macías, Eleuterio Merayo, Cuerda, Victor Moreno, Silbiger, Vivian N., Oliveira, Silviene F., Parellada, Mara, Santos, Ney P. C., Pérez-Matute, Patricia, Perez, Patricia, Perucho, Teresa, Porras-Hurtado, Gloria L., Pujol, Aurora, Fernández-Rodríguez, Amanda, Jimenez-Sousa, María A., Rodríguez-Ruiz, Emilio, Rodriguez-Artalejo, Fernando, Rodriguez-Garcia, José A., Ruiz-Cabello, Francisco, Soria, José Manuel, Tamayo, Eduardo, Teper, Alejandro, Torres-Tobar, Lilian, Urioste, Miguel, Yáñez, Zuleima, Zarate, Ruth, Guillen-Navarro, Encarna, Ayuso, Carmen, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Lapunzina, Pablo, Cruz, Raquel, Diz-de Almeida, Silvia, Ceballos, Francisco C., Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Quintela, Inés, Pita, Guillermo, Gago-Domínguez, Manuela, Porras, Marta Sevilla, Tenorio-Castaño, Jair Antonio, Nevado, Julian, Aguado, Jose María, Aguilera-Albesa, Sergio, Almadana, Virginia, Almoguera, Berta, Alvarez, Nuria, Andreu-Bernabeu, Álvaro, Arango, Celso, Artiga, Maria-Jesus, Barreda-Sánchez, María, Belhassen-Garcia, Moncef, Boix-Palop, Lucía, Brion, María, Carbonell, Cristina, Castelao, Jose E., Cortes-Sanchez, Jose L., Corton, Marta, Darnaude, M. Teresa, del Campo-Pérez, Victor, de Bustamante, Aranzazu Diaz, Luchessi, Andre D., Eiros, Rocío, Sanabria, Gladys Mercedes Estigarribia, Fernández-Robelo, Uxía, Fernández-Villa, Tania, Gómez-Arrue, Javier, Álvarez, Beatriz González, de Quirós, Fernan Gonzalez Bernaldo, González-Peñas, Javier, Gutiérrez-Bautista, Juan F., Herrero-Gonzalez, Antonio, Borja, Anabel Liger, Lopez-Rodriguez, Rosario, Mancebo, Esther, Martinez-Resendez, Michel F., Martinez-Perez, Angel, Minguez, Pablo, Ortega-Paino, Eva, Paz-Artal, Estela, Pérez-Tomás, M. Elena, Pinsach-Abuin, Mel·lina, Pompa-Mera, Ericka N., León, Soraya Ramiro, Resino, Salvador, Fernandes, Marianne R., Ruiz-Hornillos, Javier, Ryan, Pablo, Souto, Juan Carlos, Tamayo-Velasco, Alvaro, Taracido-Fernandez, Juan Carlos, Valencia-Ramos, Juan, de Heredia, Miguel López, Pedersen, Ole B., Erikstrup, Christian, Ostrowski, Sisse R., Stefansson, Kari, Mikkelsen, Susan, Sørensen, Erik, Burgos, Celia, Andersen, Steffen, Brugdorf, Kristoffer, Hansen, Thomas F., Hjalgrim, Henrik, Jemec, Gregor B., Nyegaard, Mette, Werge, Thomas, Johansson, Pär I., Didriksen, Maria, Schwinn, Michael, Jacobsen, Rikke L., Hindhede, Lotte, Rostgaard, Klaus, Gudbjartsson, Daniel, Stefánsson, Hreinn, Þorsteinsdóttir, Unnur, Nielsen, Kaspar R., Bruun, Mie Topholm, Dinh, Khoa M., Larsen, Margit A. H., Sækmose, Susanne G., Zeberg, Hugo, Nkambul, Lindo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklos, Tardif, Nicolas, Rooyackers, Olav, Grip, Jonathan, Maricic, Tomislav, Heid, Iris M., Wagner, Ralf, Überla, Klaus, Winkler, Thomas W., Wiegrebe, Simon, Gorski, Mathias, Stark, Klaus J., Peterhoff, David, Einhauser, Sebastian, Niller, Hans-Helmut, Beileke, Stephanie, Johnson, Ruth, Freimer, Nelson, Ding, Yi, Chiu, Alec, Chang, Timothy S., Boutros, Paul, Karczewski, Konrad J., Martin, Alicia R., Wilson, Daniel J., Spencer, Chris C. A., Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikolas, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Solomonson, Matthew, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline I., King, Daniel, Zhou, Wei, Seed, Cotton, Daly, Mark J., Finucane, Hilary, Bryant, Sam, Satterstrom, F. Kyle, Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicolas, Koelling, Nils, Armstrong, Jacob, Rudkin, Justine K., Callier, Shawneequa, Cusick, Caroline, Fernandez-Cadenas, Israel, Planas, Anna M., Perez-Tur, Jordi, Llucià-Carol, Laia, Cullell, Natalia, Muiño, Elena, Cárcel-Márquez, Jara, DeDiego, Marta L., Iglesias, Lara Lloret, Soriano, Alex, Rico, Veronica, Agüero, Daiana, Bedini, Josep L., Lozano, Francisco, Domingo, Carlos, Robles, Veronica, Ruiz-Jaén, Francisca, Márquez, Leonardo, Gomez, Juan, Coto, Eliecer, Albaiceta, Guillermo M., García-Clemente, Marta, Dalmau, David, Arranz, Maria J., Dietl, Beatriz, Serra-Llovich, Alex, Soler-Palacin, Pere, Colobran, Roger, Martin-Nalda, Andrea, Parra-Martínez, Alba, Bernardo, David, Rojo, Silvia, Fiz-López, Aida, Arribas-Rodriguez, Elisa, Cal-Sabater, Paloma, Segura, Tomás, González-Villar, Esther, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Jiménez-Xarrié, Elena, de Felipe Mimbrera, Alicia, Masjuan, Jaime, García-Madrona, Sebastian, Domínguez-Mayoral, Anna, Villalonga, Joan Montaner, and Menéndez-Valladares, Paloma
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- 2023
19. Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
- Author
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Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Comunidad de Madrid, China Scholarship Council, Universidad Complutense de Madrid, Zheng, Kang, Hao, Fengjie, Medrano-García, Sandra, Chen, Chaobo, Guo, Feifei, Morán-Blanco, Laura, Rodríguez-Perales, Sandra, Torres-Ruiz, Raúl, Peligros, María Isabel, Vaquero, Javier, Bañares, Rafael, Gómez del Moral, Manuel, Regueiro, José R., Martínez-Naves, Eduardo, Ramadan Mohamed, Mohamed, Gallego-Durán, Rocío, Maya-Miles, Douglas, Ampuero, Javier, Romero-Gómez, Manuel, Gilbert-Ramos, Albert, Guixé-Muntet, Sergi, Fernández-Iglesias, Anabel, Gracia-Sancho, Jordi, Coll, Mar, Graupera, Isabel, Ginès, Pere, Ciudin, Andreea, Rivera-Esteban, Jesús, Pericàs, Juan M., Frutos, María Dolores, Ramos-Molina, Bruno, Herranz, José María, Ávila, Matías A., Nevzorova, Yulia A., Fernández-Malavé, Edgar, Cubero, Francisco Javier, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Comunidad de Madrid, China Scholarship Council, Universidad Complutense de Madrid, Zheng, Kang, Hao, Fengjie, Medrano-García, Sandra, Chen, Chaobo, Guo, Feifei, Morán-Blanco, Laura, Rodríguez-Perales, Sandra, Torres-Ruiz, Raúl, Peligros, María Isabel, Vaquero, Javier, Bañares, Rafael, Gómez del Moral, Manuel, Regueiro, José R., Martínez-Naves, Eduardo, Ramadan Mohamed, Mohamed, Gallego-Durán, Rocío, Maya-Miles, Douglas, Ampuero, Javier, Romero-Gómez, Manuel, Gilbert-Ramos, Albert, Guixé-Muntet, Sergi, Fernández-Iglesias, Anabel, Gracia-Sancho, Jordi, Coll, Mar, Graupera, Isabel, Ginès, Pere, Ciudin, Andreea, Rivera-Esteban, Jesús, Pericàs, Juan M., Frutos, María Dolores, Ramos-Molina, Bruno, Herranz, José María, Ávila, Matías A., Nevzorova, Yulia A., Fernández-Malavé, Edgar, and Cubero, Francisco Javier
- Abstract
Progressive hepatic damage and fibrosis are major features of chronic liver diseases of different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member of the RAS family of small guanine nucleotide-binding proteins also encompassing the highly homologous H-RAS and K-RAS isoforms, was previously reported to modulate cell death and renal fibrosis; however, its role in liver damage and fibrogenesis remains unknown. Here, we approached this question by using N-RAS deficient (N-RAS−/−) mice and two experimental models of liver injury and fibrosis, namely carbon tetrachloride (CCl4) intoxication and bile duct ligation (BDL). In wild-type (N-RAS+/+) mice both hepatotoxic procedures augmented N-RAS expression in the liver. Compared to N-RAS+/+ counterparts, N-RAS−/− mice subjected to either CCl4 or BDL showed exacerbated liver injury and fibrosis, which was associated with enhanced hepatic stellate cell (HSC) activation and leukocyte infiltration in the damaged liver. At the molecular level, after CCl4 or BDL, N-RAS−/− livers exhibited augmented expression of necroptotic death markers along with JNK1/2 hyperactivation. In line with this, N-RAS ablation in a human hepatocytic cell line resulted in enhanced activation of JNK and necroptosis mediators in response to cell death stimuli. Of note, loss of hepatic N-RAS expression was characteristic of chronic liver disease patients with fibrosis. Collectively, our study unveils a novel role for N-RAS as a negative controller of the progression of liver injury and fibrogenesis, by critically downregulating signaling pathways leading to hepatocyte necroptosis. Furthermore, it suggests that N-RAS may be of potential clinical value as prognostic biomarker of progressive fibrotic liver damage, or as a novel therapeutic target for the treatment of chronic liver disease.
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- 2023
20. Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity
- Author
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Ministero della Salute, Istituti di Ricovero e Cura a Carattere Scientifico, European Commission, Research Council of Norway, Federal Ministry of Education and Research (Germany), Banca Intesa Sanpaolo, Institut Germans Trias i Pujol, Generalitat de Catalunya, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Agència de Gestió d'Ajuts Universitaris i de Recerca, National Institute of Allergy and Infectious Diseases (US), National Institutes of Health (US), Tedbury, Philip R., Manfredi, Candela, Degenhardt, Frauke, Conway, Joseph, Horwath, Michael C., McCracken, Courtney, Sorscher, Adam J., Moreau, Sandy, Wright, Christine, Edwards, Carolina, Brewer, Jo, Guarner, Jeannette, Wit, Emmie de, Williamson, Brandi N., Suthar, Mehul S., Ong, Yee T., Roback, John D., Alter, David N., Holter, Jan C., Karlsen, Tom H., Sacchi, Nicoletta, Romero-Gómez, Manuel, Invernizzi, Pietro, Fernández, Javier, Buti, Maria, Albillos, Agustin, Julià, Antonio, Valenti, Luca, Asselta, Rosanna, Banales, Jesús M., Bujanda, Luis, Cid, Rafael de, Franke, André, Severe COVID-19 GWAS group, Horra, Carmen de la, Maya-Miles, Douglas, Calderón, Enrique J., Medrano, Francisco Javier, Ampuero, Javier, Martín, Javier, Dopazo, Joaquín, Delgado, Juan, Guerrero, Juan M., Acosta-Herrera, Marialbert, Gallego-Durán, Rocío, Morilla Romero de la Osa, R., Friaza Patiño, Vicente, Sarafianos, Stefan G., Hong, Jeong S., Sorscher, Eric J., Ehrhardt, Annette, Ministero della Salute, Istituti di Ricovero e Cura a Carattere Scientifico, European Commission, Research Council of Norway, Federal Ministry of Education and Research (Germany), Banca Intesa Sanpaolo, Institut Germans Trias i Pujol, Generalitat de Catalunya, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Agència de Gestió d'Ajuts Universitaris i de Recerca, National Institute of Allergy and Infectious Diseases (US), National Institutes of Health (US), Tedbury, Philip R., Manfredi, Candela, Degenhardt, Frauke, Conway, Joseph, Horwath, Michael C., McCracken, Courtney, Sorscher, Adam J., Moreau, Sandy, Wright, Christine, Edwards, Carolina, Brewer, Jo, Guarner, Jeannette, Wit, Emmie de, Williamson, Brandi N., Suthar, Mehul S., Ong, Yee T., Roback, John D., Alter, David N., Holter, Jan C., Karlsen, Tom H., Sacchi, Nicoletta, Romero-Gómez, Manuel, Invernizzi, Pietro, Fernández, Javier, Buti, Maria, Albillos, Agustin, Julià, Antonio, Valenti, Luca, Asselta, Rosanna, Banales, Jesús M., Bujanda, Luis, Cid, Rafael de, Franke, André, Severe COVID-19 GWAS group, Horra, Carmen de la, Maya-Miles, Douglas, Calderón, Enrique J., Medrano, Francisco Javier, Ampuero, Javier, Martín, Javier, Dopazo, Joaquín, Delgado, Juan, Guerrero, Juan M., Acosta-Herrera, Marialbert, Gallego-Durán, Rocío, Morilla Romero de la Osa, R., Friaza Patiño, Vicente, Sarafianos, Stefan G., Hong, Jeong S., Sorscher, Eric J., and Ehrhardt, Annette
- Abstract
Patients with cystic fibrosis (CF) exhibit pronounced respiratory damage and were initially considered among those at highest risk for serious harm from SARS-CoV-2 infection. Numerous clinical studies have subsequently reported that individuals with CF in North America and Europe—while susceptible to severe COVID-19—are often spared from the highest levels of virus-associated mortality. To understand features that might influence COVID-19 among patients with cystic fibrosis, we studied relationships between SARS-CoV-2 and the gene responsible for CF (i.e., the cystic fibrosis transmembrane conductance regulator, CFTR). In contrast to previous reports, we found no association between CFTR carrier status (mutation heterozygosity) and more severe COVID-19 clinical outcomes. We did observe an unexpected trend toward higher mortality among control individuals compared with silent carriers of the common F508del CFTR variant—a finding that will require further study. We next performed experiments to test the influence of homozygous CFTR deficiency on viral propagation and showed that SARS-CoV-2 production in primary airway cells was not altered by the absence of functional CFTR using two independent protocols. On the contrary, experiments performed in vitro strongly indicated that virus proliferation depended on features of the mucosal fluid layer known to be disrupted by absent CFTR in patients with CF, including both low pH and increased viscosity. These results point to the acidic, viscous, and mucus-obstructed airways in patients with cystic fibrosis as unfavorable for the establishment of coronaviral infection. Our findings provide new and important information concerning relationships between the CF clinical phenotype and severity of COVID-19.
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- 2023
21. Supplementary material to: Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
- Author
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Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Comunidad de Madrid, China Scholarship Council, Universidad Complutense de Madrid, Zheng, Kang, Hao, Fengjie, Medrano-García, Sandra, Chen, Chaobo, Guo, Feifei, Morán-Blanco, Laura, Rodríguez-Perales, Sandra, Torres-Ruiz, Raúl, Peligros, María Isabel, Vaquero, Javier, Bañares, Rafael, Gómez del Moral, Manuel, Regueiro, José R., Martínez-Naves, Eduardo, Ramadan Mohamed, Mohamed, Gallego-Durán, Rocío, Maya-Miles, Douglas, Ampuero, Javier, Romero-Gómez, Manuel, Gilbert-Ramos, Albert, Guixé-Muntet, Sergi, Fernández-Iglesias, Anabel, Gracia-Sancho, Jordi, Coll, Mar, Graupera, Isabel, Ginès, Pere, Ciudin, Andreea, Rivera-Esteban, Jesús, Pericàs, Juan M., Frutos, María Dolores, Ramos-Molina, Bruno, Herranz, José María, Ávila, Matías A., Nevzorova, Yulia A., Fernández-Malavé, Edgar, Cubero, Francisco Javier, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Comunidad de Madrid, China Scholarship Council, Universidad Complutense de Madrid, Zheng, Kang, Hao, Fengjie, Medrano-García, Sandra, Chen, Chaobo, Guo, Feifei, Morán-Blanco, Laura, Rodríguez-Perales, Sandra, Torres-Ruiz, Raúl, Peligros, María Isabel, Vaquero, Javier, Bañares, Rafael, Gómez del Moral, Manuel, Regueiro, José R., Martínez-Naves, Eduardo, Ramadan Mohamed, Mohamed, Gallego-Durán, Rocío, Maya-Miles, Douglas, Ampuero, Javier, Romero-Gómez, Manuel, Gilbert-Ramos, Albert, Guixé-Muntet, Sergi, Fernández-Iglesias, Anabel, Gracia-Sancho, Jordi, Coll, Mar, Graupera, Isabel, Ginès, Pere, Ciudin, Andreea, Rivera-Esteban, Jesús, Pericàs, Juan M., Frutos, María Dolores, Ramos-Molina, Bruno, Herranz, José María, Ávila, Matías A., Nevzorova, Yulia A., Fernández-Malavé, Edgar, and Cubero, Francisco Javier
- Abstract
Progressive hepatic damage and fibrosis are major features of chronic liver diseases of different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member of the RAS family of small guanine nucleotide-binding proteins also encompassing the highly homologous H-RAS and K-RAS isoforms, was previously reported to modulate cell death and renal fibrosis; however, its role in liver damage and fibrogenesis remains unknown. Here, we approached this question by using N-RAS deficient (N-RAS−/−) mice and two experimental models of liver injury and fibrosis, namely carbon tetrachloride (CCl4) intoxication and bile duct ligation (BDL). In wild-type (N-RAS+/+) mice both hepatotoxic procedures augmented N-RAS expression in the liver. Compared to N-RAS+/+ counterparts, N-RAS−/− mice subjected to either CCl4 or BDL showed exacerbated liver injury and fibrosis, which was associated with enhanced hepatic stellate cell (HSC) activation and leukocyte infiltration in the damaged liver. At the molecular level, after CCl4 or BDL, N-RAS−/− livers exhibited augmented expression of necroptotic death markers along with JNK1/2 hyperactivation. In line with this, N-RAS ablation in a human hepatocytic cell line resulted in enhanced activation of JNK and necroptosis mediators in response to cell death stimuli. Of note, loss of hepatic N-RAS expression was characteristic of chronic liver disease patients with fibrosis. Collectively, our study unveils a novel role for N-RAS as a negative controller of the progression of liver injury and fibrogenesis, by critically downregulating signaling pathways leading to hepatocyte necroptosis. Furthermore, it suggests that N-RAS may be of potential clinical value as prognostic biomarker of progressive fibrotic liver damage, or as a novel therapeutic target for the treatment of chronic liver disease.
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- 2023
22. Role of EpCAM+ CD133+ extracellular vesicles in steatosis to steatohepatitis transition in NAFLD
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Junta de Andalucía, Sociedad Andaluza de Patología Digestiva, European Commission, Instituto de Salud Carlos III, Comunidad de Madrid, Muñoz-Hernández, Rocío, Gato, Sheila, Gil-Gómez, Antonio, Aller, Rocío, Rojas, Ángela, Morán, Laura, Gallego, Javier, Blázquez-López, Elena, Gallego-Durán, Rocío, Montero-Vallejo, Rocío, García-Fernández, Vanessa, Maya-Miles, Douglas, Rico, María Carmen, Cubero, Francisco Javier, Vaquero, Javier, Ampuero, Javier, Bañares, Rafael, Romero-Gómez, Manuel, Junta de Andalucía, Sociedad Andaluza de Patología Digestiva, European Commission, Instituto de Salud Carlos III, Comunidad de Madrid, Muñoz-Hernández, Rocío, Gato, Sheila, Gil-Gómez, Antonio, Aller, Rocío, Rojas, Ángela, Morán, Laura, Gallego, Javier, Blázquez-López, Elena, Gallego-Durán, Rocío, Montero-Vallejo, Rocío, García-Fernández, Vanessa, Maya-Miles, Douglas, Rico, María Carmen, Cubero, Francisco Javier, Vaquero, Javier, Ampuero, Javier, Bañares, Rafael, and Romero-Gómez, Manuel
- Abstract
[Background and Aims] Extracellular vesicles (EVs) have emerged as a potential source of circulating biomarkers in liver disease. We evaluated circulating AV+ EpCAM+ CD133+ EVs as a potential biomarker of the transition from simple steatosis to steatohepatitis., [Methods] EpCAM and CD133 liver proteins and EpCAM+ CD133+ EVs levels were analysed in 31 C57BL/6J mice fed with a chow or high fat, high cholesterol and carbohydrates diet (HFHCC) for 52 weeks. The hepatic origin of MVs was addressed using AlbCrexmT/mG mice fed a Western (WD) or Dual diet for 23 weeks. Besides, we assessed plasma MVs in 130 biopsy-proven NAFLD patients., [Results] Hepatic expression of EpCAM and CD133 and EpCAM+ CD133+ EVs increased during disease progression in HFHCC mice. GFP+ MVs were higher in AlbCrexmT/mG mice fed a WD (5.2% vs 12.1%) or a Dual diet (0.5% vs 7.3%). Most GFP+ MVs were also positive for EpCAM and CD133 (98.3% and 92.9% respectively), suggesting their hepatic origin. In 71 biopsy-proven NAFLD patients, EpCAM+ CD133+ EVs were significantly higher in those with steatohepatitis compare to those with simple steatosis (286.4 ± 61.9 vs 758.4 ± 82.3; p < 0.001). Patients with ballooning 367 ± 40.6 vs 532.0 ± 45.1; p = 0.01 and lobular inflammation (321.1 ± 74.1 vs 721.4 ± 80.1; p = 0.001), showed higher levels of these EVs. These findings were replicated in an independent cohort., [Conclusions] Circulating levels of EpCAM+ CD133+ MVs in clinical and experimental NAFLD were increased in the presence of steatohepatitis, showing high potential as a non-invasive biomarker for the evaluation and management of these patients.
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- 2023
23. Crosstalk between chromatin structure, cohesin activity and transcription
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Maya-Miles, Douglas, Andújar, Eloísa, Pérez-Alegre, Mónica, Murillo-Pineda, Marina, Barrientos-Moreno, Marta, Cabello-Lobato, María J., Gómez-Marín, Elena, Morillo-Huesca, Macarena, and Prado, Félix
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- 2019
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24. Role of EpCAM+ CD133+ extracellular vesicles in steatosis to steatohepatitis transition in NAFLD.
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Muñoz‐Hernández, Rocío, Gato, Sheila, Gil‐Gómez, Antonio, Aller, Rocío, Rojas, Angela, Morán, Laura, Gallego, Javier, Blázquez‐López, Elena, Gallego‐Durán, Rocío, Montero‐Vallejo, Rocío, García‐Fernández, Vanessa, Maya‐Miles, Douglas, Rico, María del C, Cubero, Francisco J, Vaquero, Javier, Ampuero, Javier, Bañares, Rafael, and Romero‐Gómez, Manuel
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FATTY liver ,EXTRACELLULAR vesicles ,NON-alcoholic fatty liver disease ,FATTY degeneration ,HIGH-carbohydrate diet ,HIGH cholesterol diet - Abstract
Background and Aims: Extracellular vesicles (EVs) have emerged as a potential source of circulating biomarkers in liver disease. We evaluated circulating AV+ EpCAM+ CD133+ EVs as a potential biomarker of the transition from simple steatosis to steatohepatitis. Methods: EpCAM and CD133 liver proteins and EpCAM+ CD133+ EVs levels were analysed in 31 C57BL/6J mice fed with a chow or high fat, high cholesterol and carbohydrates diet (HFHCC) for 52 weeks. The hepatic origin of MVs was addressed using AlbCrexmT/mG mice fed a Western (WD) or Dual diet for 23 weeks. Besides, we assessed plasma MVs in 130 biopsy‐proven NAFLD patients. Results: Hepatic expression of EpCAM and CD133 and EpCAM+ CD133+ EVs increased during disease progression in HFHCC mice. GFP+ MVs were higher in AlbCrexmT/mG mice fed a WD (5.2% vs 12.1%) or a Dual diet (0.5% vs 7.3%). Most GFP+ MVs were also positive for EpCAM and CD133 (98.3% and 92.9% respectively), suggesting their hepatic origin. In 71 biopsy‐proven NAFLD patients, EpCAM+ CD133+ EVs were significantly higher in those with steatohepatitis compare to those with simple steatosis (286.4 ± 61.9 vs 758.4 ± 82.3; p < 0.001). Patients with ballooning 367 ± 40.6 vs 532.0 ± 45.1; p = 0.01 and lobular inflammation (321.1 ± 74.1 vs 721.4 ± 80.1; p = 0.001), showed higher levels of these EVs. These findings were replicated in an independent cohort. Conclusions: Circulating levels of EpCAM+ CD133+ MVs in clinical and experimental NAFLD were increased in the presence of steatohepatitis, showing high potential as a non‐invasive biomarker for the evaluation and management of these patients. [ABSTRACT FROM AUTHOR]
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- 2023
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25. Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
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Gil-Gómez, Antonio, primary, Rojas, Ángela, additional, García-Lozano, María R., additional, Muñoz-Hernández, Rocío, additional, Gallego-Durán, Rocío, additional, Maya-Miles, Douglas, additional, Montero-Vallejo, Rocío, additional, Gato, Sheila, additional, Gallego, Javier, additional, Francés, Rubén, additional, Soriano, Germán, additional, Ampuero, Javier, additional, and Romero-Gómez, Manuel, additional
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- 2022
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26. Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
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NordForsk, Academy of Finland, Canadian Institutes of Health Research, Lady Davis Institute, Canada Foundation for Innovation, Cancer Research UK, National Institutes of Health (US), Genome Canada, Japan Society for the Promotion of Science, European Commission, Medical Research Council (UK), National Institute for Health Research (UK), Wellcome Trust, German Research Foundation, Federal Ministry of Education and Research (Germany), Instituto de Salud Carlos III, Junta de Andalucía, Columbia University, Università degli Studi di Siena, Ministero della Salute, Consejo Superior de Investigaciones Científicas (España), Swedish Research Council, Technical University of Munich, University of Helsinki, Nakanishi, Tomoko [0000-0001-9510-5646], Pigazzini, Sara [0000-0002-0641-9393], Cordioli, Mattia [0000-0002-4872-0520], Butler-Laporte, Guillaume [0000-0001-5388-0396], Maya-Miles, Douglas [0000-0002-0669-6526], Nafria Jimenez, Beatriz [0000-0002-4698-5680], Bouysran, Youssef [0000-0003-1368-6550], Niemi, Mari [0000-0003-0696-6175], Palom, Adriana [0000-0002-0130-1302], Ellinghaus, David [0000-0002-4332-6110], Khan, Atlas [0000-0002-6651-2725], Martínez-Bueno, Manuel [0000-0002-4333-4487], Roade, Luisa [0000-0002-8160-9613], Fava, Francesca [0000-0002-4363-2353], Spinner, Christoph D. [0000-0002-3875-5367], Prati, Daniele [0000-0002-2281-7498], Bernardo, David [0000-0002-2843-6696], Darcis, Gilles [0000-0001-8192-1351], Fernández-Cadenas, Israel [0000-0003-4821-2363], Holter, Jan Cato [0000-0003-1618-5022], Frithiof, Robert [0000-0003-2278-7951], Kiryluk, Krzysztof [0000-0002-5047-6715], Duga, Stefano [0000-0003-3457-1410], Asselta, Rosanna [0000-0001-5351-0619], Pereira, Alexandre [0000-0002-7782-5540], Romero-Gómez, Manuel [0000-0001-8494-8947], Hov, Johannes R. [0000-0002-5900-8096], Migeotte, Isabelle [0000-0002-8972-8211], Renieri, Alessandra [0000-0002-0846-9220], Planas, Anna M. [0000-0002-6147-1880], Ludwig, Kerstin [0000-0002-8541-2519], Buti, María [0000-0002-0732-3078], Rahmouni, Souad [0000-0003-0956-0242], Alarcón-Riquelme, M. E. [0000-0002-7632-4154], Schulte, Eva C. [0000-0003-3105-5672], Karlsen, Tom H. [0000-0002-8289-9931], Valenti, Luca [0000-0001-8909-0345], Zeberg, Hugo [0000-0001-7118-1249], Richards, Brent [0000-0002-3746-9086], Ganna, Andrea [0000-0002-8147-240X], Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Cordioli, Mattia, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Nafría-Jiménez, Beatriz, Bouysran, Youssef, Niemi, Mari, Palom, Adriana, Ellinghaus, David, Khan, Atlas, Martínez-Bueno, Manuel, Rolker, Selina, Amitano, Sara, Roade, Luisa, FinnGen, The COVID-19 Host Genetics Initiative, Fava, Francesca, Spinner, Christoph D., Prati, Daniele, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesús M., Frithiof, Robert, Kiryluk, Krzysztof, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre, Romero-Gómez, Manuel, Bujanda, Luis, Hov, Johannes R., Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M., Ludwig, Kerstin, Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Franke, Andre, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Richards, Brent, Ganna, Andrea, NordForsk, Academy of Finland, Canadian Institutes of Health Research, Lady Davis Institute, Canada Foundation for Innovation, Cancer Research UK, National Institutes of Health (US), Genome Canada, Japan Society for the Promotion of Science, European Commission, Medical Research Council (UK), National Institute for Health Research (UK), Wellcome Trust, German Research Foundation, Federal Ministry of Education and Research (Germany), Instituto de Salud Carlos III, Junta de Andalucía, Columbia University, Università degli Studi di Siena, Ministero della Salute, Consejo Superior de Investigaciones Científicas (España), Swedish Research Council, Technical University of Munich, University of Helsinki, Nakanishi, Tomoko [0000-0001-9510-5646], Pigazzini, Sara [0000-0002-0641-9393], Cordioli, Mattia [0000-0002-4872-0520], Butler-Laporte, Guillaume [0000-0001-5388-0396], Maya-Miles, Douglas [0000-0002-0669-6526], Nafria Jimenez, Beatriz [0000-0002-4698-5680], Bouysran, Youssef [0000-0003-1368-6550], Niemi, Mari [0000-0003-0696-6175], Palom, Adriana [0000-0002-0130-1302], Ellinghaus, David [0000-0002-4332-6110], Khan, Atlas [0000-0002-6651-2725], Martínez-Bueno, Manuel [0000-0002-4333-4487], Roade, Luisa [0000-0002-8160-9613], Fava, Francesca [0000-0002-4363-2353], Spinner, Christoph D. [0000-0002-3875-5367], Prati, Daniele [0000-0002-2281-7498], Bernardo, David [0000-0002-2843-6696], Darcis, Gilles [0000-0001-8192-1351], Fernández-Cadenas, Israel [0000-0003-4821-2363], Holter, Jan Cato [0000-0003-1618-5022], Frithiof, Robert [0000-0003-2278-7951], Kiryluk, Krzysztof [0000-0002-5047-6715], Duga, Stefano [0000-0003-3457-1410], Asselta, Rosanna [0000-0001-5351-0619], Pereira, Alexandre [0000-0002-7782-5540], Romero-Gómez, Manuel [0000-0001-8494-8947], Hov, Johannes R. [0000-0002-5900-8096], Migeotte, Isabelle [0000-0002-8972-8211], Renieri, Alessandra [0000-0002-0846-9220], Planas, Anna M. [0000-0002-6147-1880], Ludwig, Kerstin [0000-0002-8541-2519], Buti, María [0000-0002-0732-3078], Rahmouni, Souad [0000-0003-0956-0242], Alarcón-Riquelme, M. E. [0000-0002-7632-4154], Schulte, Eva C. [0000-0003-3105-5672], Karlsen, Tom H. [0000-0002-8289-9931], Valenti, Luca [0000-0001-8909-0345], Zeberg, Hugo [0000-0001-7118-1249], Richards, Brent [0000-0002-3746-9086], Ganna, Andrea [0000-0002-8147-240X], Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Cordioli, Mattia, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Nafría-Jiménez, Beatriz, Bouysran, Youssef, Niemi, Mari, Palom, Adriana, Ellinghaus, David, Khan, Atlas, Martínez-Bueno, Manuel, Rolker, Selina, Amitano, Sara, Roade, Luisa, FinnGen, The COVID-19 Host Genetics Initiative, Fava, Francesca, Spinner, Christoph D., Prati, Daniele, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesús M., Frithiof, Robert, Kiryluk, Krzysztof, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre, Romero-Gómez, Manuel, Bujanda, Luis, Hov, Johannes R., Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M., Ludwig, Kerstin, Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Franke, Andre, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Richards, Brent, and Ganna, Andrea
- Abstract
Background There is considerable variability in COVID-19 outcomes amongst younger adults—and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium. Method The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors. Findings We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1·4, 95% confidence interval [CI] 1·2–1·6) and COVID-19 related mortality (HR 1·5, 95%CI 1·3–1·8). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2·0, 95%CI 1·6-2·6), venous thromboembolism (OR 1·7, 95%CI 1·2-2·4), and hepatic injury (OR 1·6, 95%CI 1·2-2·0). Risk allele carriers ≤ 60 years had higher odds of death or severe respiratory failure (OR 2·6, 95%CI 1·8-3·9) compared to those > 60 years OR 1·5 (95%CI 1·3-1·9, interaction p-value=0·04). Amongst individuals ≤ 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31·8% (95%CI 27·6-36·2) were risk variant carriers, compared to 13·9% (95%CI 12·6-15·2%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those ≤ 60 years improved when including the risk allele (AUC 0·82 vs 0·84, p=0·016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk fact
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- 2021
27. Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
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Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Cordioli, Mattia, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Nafria Jimenez, Beatriz, Bouysran, Youssef, Niemi, Mari, Palom, Adriana, Ellinghaus, David, Khan, Atlas, Martínez-Bueno, Manuel, Rolker, Selina, Amitano, Sara, Roade, Luisa, FinnGen, The COVID-19 Host Genetics Initiative, Fava, Francesca, Spinner, Christoph D., Prati, Daniele, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesús M., Frithiof, Robert, Kiryluk, Krzysztof, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre, Romero-Gómez, Manuel, Bujanda, Luis, Hov, Johannes R., Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M., Ludwig, Kerstin, Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Franke, Andre, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Richards, Brent, Ganna, Andrea, NordForsk, Academy of Finland, Canadian Institutes of Health Research, Lady Davis Institute, Canada Foundation for Innovation, Cancer Research UK, National Institutes of Health (US), Genome Canada, Japan Society for the Promotion of Science, European Commission, Medical Research Council (UK), National Institute for Health Research (UK), Wellcome Trust, German Research Foundation, Federal Ministry of Education and Research (Germany), Instituto de Salud Carlos III, Junta de Andalucía, Columbia University, Università degli Studi di Siena, Ministero della Salute, Consejo Superior de Investigaciones Científicas (España), Swedish Research Council, Technical University of Munich, University of Helsinki, Nakanishi, Tomoko [0000-0001-9510-5646], Pigazzini, Sara [0000-0002-0641-9393], Cordioli, Mattia [0000-0002-4872-0520], Butler-Laporte, Guillaume [0000-0001-5388-0396], Maya-Miles, Douglas [0000-0002-0669-6526], Nafria Jimenez, Beatriz [0000-0002-4698-5680], Bouysran, Youssef [0000-0003-1368-6550], Niemi, Mari [0000-0003-0696-6175], Palom, Adriana [0000-0002-0130-1302], Ellinghaus, David [0000-0002-4332-6110], Khan, Atlas [0000-0002-6651-2725], Martínez-Bueno, Manuel [0000-0002-4333-4487], Roade, Luisa [0000-0002-8160-9613], Fava, Francesca [0000-0002-4363-2353], Spinner, Christoph D. [0000-0002-3875-5367], Prati, Daniele [0000-0002-2281-7498], Bernardo, David [0000-0002-2843-6696], Darcis, Gilles [0000-0001-8192-1351], Fernández-Cadenas, Israel [0000-0003-4821-2363], Holter, Jan Cato [0000-0003-1618-5022], Frithiof, Robert [0000-0003-2278-7951], Kiryluk, Krzysztof [0000-0002-5047-6715], Duga, Stefano [0000-0003-3457-1410], Asselta, Rosanna [0000-0001-5351-0619], Pereira, Alexandre [0000-0002-7782-5540], Romero-Gómez, Manuel [0000-0001-8494-8947], Hov, Johannes R. [0000-0002-5900-8096], Migeotte, Isabelle [0000-0002-8972-8211], Renieri, Alessandra [0000-0002-0846-9220], Planas, Anna M. [0000-0002-6147-1880], Ludwig, Kerstin [0000-0002-8541-2519], Buti, María [0000-0002-0732-3078], Rahmouni, Souad [0000-0003-0956-0242], Alarcón-Riquelme, M. E. [0000-0002-7632-4154], Schulte, Eva C. [0000-0003-3105-5672], Karlsen, Tom H. [0000-0002-8289-9931], Valenti, Luca [0000-0001-8909-0345], Zeberg, Hugo [0000-0001-7118-1249], Richards, Brent [0000-0002-3746-9086], Ganna, Andrea [0000-0002-8147-240X], Junta de Castilla y León, Fundació Glòria Soler, Swedish Kidney Foundation, Research Council of Norway, Nakanishi, Tomoko, Pigazzini, Sara, Cordioli, Mattia, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Nafria Jimenez, Beatriz, Bouysran, Youssef, Niemi, Mari, Palom, Adriana, Ellinghaus, David, Khan, Atlas, Martínez-Bueno, Manuel, Roade, Luisa, Fava, Francesca, Spinner, Christoph D., Prati, Daniele, Bernardo, David, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Frithiof, Robert, Kiryluk, Krzysztof, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre, Romero-Gómez, Manuel, Hov, Johannes R., Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M., Ludwig, Kerstin, Buti, María, Rahmouni, Souad, Alarcón-Riquelme, M. E., Schulte, Eva C., Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Richards, Brent, Ganna, Andrea, Nakanishi, T., Pigazzini, S., Degenhardt, F., Cordioli, M., Butler-Laporte, G., Maya-Miles, D., Bujanda, L., Bouysran, Y., Niemi, M. E. K., Palom, A., Ellinghaus, D., Khan, A., Martinez-Bueno, M., Rolker, S., Amitrano, S., Tato, L. R., Fava, F., Gen, F., Spinner, C. D., Prati, D., Bernardo, D., Garcia, F., Darcis, G., Fernandez-Cadenas, I., Holter, J. C., Banales, J. M., Frithiof, R., Kiryluk, K., Duga, S., Asselta, R., Pereira, A. C., Romero-Gomez, M., Nafria-Jimenez, B., Hov, J. R., Migeotte, I., Renieri, A., Planas, A. M., Ludwig, K. U., Buti, M., Rahmouni, S., Alarcon-Riquelme, M. E., Schulte, E. C., Franke, A., Karlsen, T. H., Valenti, L., Zeberg, H., Richards, J. B., and Ganna, A.
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Male ,Coronavirus disease 2019 (COVID-19) ,Age dependent ,Article ,03 medical and health sciences ,0302 clinical medicine ,Genetic ,Gene Frequency ,Risk Factors ,Genetics ,Medicine ,Humans ,Age Factor ,Genetic variation ,030212 general & internal medicine ,Respiratory system ,Alleles ,030304 developmental biology ,Aged ,Allele ,Aged, 80 and over ,0303 health sciences ,Polymorphism, Genetic ,business.industry ,SARS-CoV-2 ,Risk Factor ,Hazard ratio ,Age Factors ,Patient Acuity ,COVID-19 ,Odds ratio ,Covid-19 ,Genetic Variation ,Sciences bio-médicales et agricoles ,Middle Aged ,COVID-19 (Enfermedad) ,Confidence interval ,3. Good health ,Genetic Loci ,Commentary ,Female ,Chromosomes, Human, Pair 3 ,Genetic risk factor ,business ,Venous thromboembolism ,Human ,Demography - Abstract
AG has received support by NordForsk Nordic Trial Alliance (NTA) grant, by Academy of Finland Fellow grant N. 323116 and the Academy of Finland for PREDICT consortium N. 340541. The Richards research group is supported by the Canadian Institutes of Health Research (CIHR) (365825 and 409511), the Lady Davis Institute of the Jewish General Hospital, the Canadian Foundation for Innovation (CFI), the NIH Foundation, Cancer Research UK, Genome Québec, the Public Health Agency of Canada, the McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé (FRQS). TN is supported by a research fellowship of the Japan Society for the Promotion of Science for Young Scientists. GBL is supported by a CIHR scholarship and a joint FRQS and Québec Ministry of Health and Social Services scholarship. JBR is supported by an FRQS Clinical Research Scholarship. Support from Calcul Québec and Compute Canada is acknowledged. TwinsUK is funded by the Welcome Trust, the Medical Research Council, the European Union, the National Institute for Health Research-funded BioResource and the Clinical Research Facility and Biomedical Research Centre based at Guy’s and St. Thomas’ NHS Foundation Trust in partnership with King’s College London. The Biobanque Québec COVID19 is funded by FRQS, Genome Québec and the Public Health Agency of Canada, the McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé. These funding agencies had no role in the design, implementation or interpretation of this study. The COVID19-Host(a)ge study received infrastructure support from the DFG Cluster of Excellence 2167 “Precision Medicine in Chronic Inflammation (PMI)” (DFG Grant: “EXC2167”). The COVID19-Host(a)ge study was supported by the German Federal Ministry of Education and Research (BMBF) within the framework of the Computational Life Sciences funding concept (CompLS grant 031L0165). Genotyping in COVID19-Host(a)ge was supported by a philantropic donation from Stein Erik Hagen. The COVID GWAs, Premed COVID-19 study (COVID19-Host(a)ge_3) was supported by "Grupo de Trabajo en Medicina Personalizada contra el COVID-19 de Andalucia"and also by the Instituto de Salud Carlos III (CIBERehd and CIBERER). Funding comes from COVID-19-GWAS, COVID-PREMED initiatives. Both of them are supported by "Consejeria de Salud y Familias" of the Andalusian Government. DMM is currently funded by the the Andalussian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018). The Columbia University Biobank was supported by Columbia University and the National Center for Advancing Translational Sciences, NIH, through Grant Number UL1TR001873. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or Columbia University. The SPGRX study was supported by the Consejería de Economía, Conocimiento, Empresas y Universidad #CV20-10150. The GEN-COVID study was funded by: the MIUR grant “Dipartimenti di Eccellenza 2018-2020” to the Department of Medical Biotechnologies University of Siena, Italy; the “Intesa San Paolo 2020 charity fund” dedicated to the project NB/2020/0119; and philanthropic donations to the Department of Medical Biotechnologies, University of Siena for the COVID-19 host genetics research project (D.L n.18 of March 17, 2020). Part of this research project is also funded by Tuscany Region “Bando Ricerca COVID-19 Toscana” grant to the Azienda Ospedaliero Universitaria Senese (CUP I49C20000280002). Authors are grateful to: the CINECA consortium for providing computational resources; the Network for Italian Genomes (NIG) (http://www.nig.cineca.it) for its support; the COVID-19 Host Genetics Initiative (https://www.covid19hg.org/); the Genetic Biobank of Siena, member of BBMRI-IT, Telethon Network of Genetic Biobanks (project no. GTB18001), EuroBioBank, and RD-Connect, for managing specimens. Genetics against coronavirus (GENIUS), Humanitas University (COVID19-Host(a)ge_4) was supported by Ricerca Corrente (Italian Ministry of Health), intramural funding (Fondazione Humanitas per la Ricerca). The generous contribution of Banca Intesa San Paolo and of the Dolce&Gabbana Fashion Firm is gratefully acknowledged. Data acquisition and sample processing was supported by COVID-19 Biobank, Fondazione IRCCS Cà Granda Milano; LV group was supported by MyFirst Grant AIRC n.16888, Ricerca Finalizzata Ministero della Salute RF-2016-02364358, Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, the European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) for the project LITMUS- “Liver Investigation: Testing Marker Utility in Steatohepatitis”, Programme “Photonics” under grant agreement “101016726” for the project “REVEAL: Neuronal microscopy for cell behavioural examination and manipulation”, Fondazione Patrimonio Ca’ Granda “Liver Bible” PR-0361. DP was supported by Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, CV PREVITAL “Strategie di prevenzione primaria nella popolazione Italiana” Ministero della Salute, and Associazione Italiana per la Prevenzione dell’Epatite Virale (COPEV). Genetic modifiers for COVID-19 related illness (BeLCovid_1) was supported by the "Fonds Erasme". The Host genetics and immune response in SARS-Cov-2 infection (BelCovid_2) study was supported by grants from Fondation Léon Fredericq and from Fonds de la Recherche Scientifique (FNRS). The INMUNGEN-CoV2 study was funded by the Consejo Superior de Investigaciones Científicas. KUL is supported by the German Research Foundation (LU 1944/3-1) SweCovid is funded by the SciLifeLab/KAW national COVID-19 research program project grant to Michael Hultström (KAW 2020.0182) and the Swedish Research Council to Robert Frithiof (2014-02569 and 2014-07606). HZ is supported by Jeansson Stiftelser, Magnus Bergvalls Stiftelse. The COMRI cohort is funded by Technical University of Munich, Munich, Germany. Genotyping for the COMRI cohort was performed and funded by the Genotyping Laboratory of Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Helsinki, Finland. These funding agencies had no role in the design, implementation or interpretation of this study., Background: There is considerable variability in COVID-19 outcomes amongst younger adults—and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium. Method: The major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors. Findings: We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1·4, 95% confidence interval [CI] 1·2–1·6) and COVID-19 related mortality (HR 1·5, 95%CI 1·3–1·8). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2·0, 95%CI 1·6-2·6), venous thromboembolism (OR 1·7, 95%CI 1·2-2·4), and hepatic injury (OR 1·6, 95%CI 1·2-2·0). Risk allele carriers ≤ 60 years had higher odds of death or severe respiratory failure (OR 2·6, 95%CI 1·8-3·9) compared to those > 60 years OR 1·5 (95%CI 1·3-1·9, interaction p-value=0·04). Amongst individuals ≤ 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31·8% (95%CI 27·6-36·2) were risk variant carriers, compared to 13·9% (95%CI 12·6-15·2%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those ≤ 60 years improved when including the risk allele (AUC 0·82 vs 0·84, p=0·016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors. Interpretation: The major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality—and these are more pronounced amongst individuals ≤ 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management., Academy of Finland Fellow grant N. 323116, Academy of Finland for PREDICT consortium N. 340541., Canadian Institutes of Health Research (CIHR) (365825 and 409511), Lady Davis Institute of the Jewish General Hospital, Canadian Foundation for Innovation (CFI), NIH Foundation, Cancer Research UK, Genome Québec, Public Health Agency of Canada, McGill Interdisciplinary Initiative in Infection and Immunity and the Fonds de Recherche Québec Santé (FRQS), Japan Society for the Promotion of Science for Young Scientists, CIHR scholarship and a joint FRQS and Québec Ministry of Health and Social Services scholarship, FRQS Clinical Research Scholarship, Calcul Québec, Compute Canada, Welcome Trust, Medical Research Counc, European Union, National Institute for Health Research-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St. Thomas’ NHS Foundation Trust, King’s College London, McGill Interdisciplinary Initiative in Infection and Immunity, Fonds de Recherche Québec Santé, (DFG Grant: “EXC2167”), (CompLS grant 031L0165), Stein Erik Hagen, "Grupo de Trabajo en Medicina Personalizada contra el COVID-19 de Andalucia", Instituto de Salud Carlos III (CIBERehd and CIBERER), COVID-19-GWAS, COVID-PREMED initiatives, "Consejeria de Salud y Familias" of the Andalusian Government, Andalusian government (Proyectos Estratégicos-Fondos Feder PE-0451-2018), Columbia University, National Center for Advancing Translational Sciences, NIH Grant Number UL1TR001873, Consejería de Economía, Conocimiento, Empresas y Universidad #CV20-10150, MIUR grant “Dipartimenti di Eccellenza 2018-2020”, “Intesa San Paolo 2020 charity fund” dedicated to the project NB/2020/0119, Tuscany Region “Bando Ricerca COVID-19 Toscana”, CINECA consortium, Network for Italian Genomes (NIG), COVID-19 Host Genetics Initiative, Genetic Biobank of Siena, EuroBioBank, RD-Connect, Ricerca Corrente (Italian Ministry of Health), Fondazione Humanitas per la Ricerca, Banca Intesa San Paolo, Dolce&Gabbana Fashion Firm, COVID-19 Biobank, Fondazione IRCCS Cà Granda Milano, MyFirst Grant AIRC n.16888, Ricerca Finalizzata Ministero della Salute RF-2016-02364358, Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377), “Photonics” “101016726”, Fondazione Patrimonio Ca’ Granda “Liver Bible” PR-0361, CV PREVITAL “Strategie di prevenzione primaria nella popolazione Italiana” Ministero della Salute, and Associazione Italiana per la Prevenzione dell’Epatite Virale (COPEV), "Fonds Erasme", Fondation Léon Fredericq, Fonds de la Recherche Scientifique (FNRS), Consejo Superior de Investigaciones Científicas, German Research Foundation (LU 1944/3-1), SciLifeLab/KAW national COVID-19 research program project (KAW 2020.0182), Swedish Research Council (2014-02569 and 2014-07606), Jeansson Stiftelser, Magnus Bergvalls Stiftelse, Technical University of Munich, Munich, Germany, Genotyping Laboratory of Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki, Helsinki, Finland
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- 2021
28. Cysteinyl leukotrienes pathway genes, atopic asthma and drug response: From population isolates to large genome-wide association studies.
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Miles Douglas Thompson, Valeri Capra, Mark Clunes, G. Enrico Rovati, Mary Maj, Jana Stankova, and David Duffy
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Mutation ,Pharmacogenetics ,Polymorphism, Genetic ,pharmacogenomics ,personalized medicine ,leukotriene ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Genetic studies have identified genetic variants associated with asthma pathogenesis and altered response to drug therapy. Many studies implicate polymorphisms in genes encoding the enzymes responsible for leukotriene synthesis and intracellular signaling through activation of seven transmembrane domain receptors, such as the cysteinyl leukotriene 1 (CYSLTR1) and 2 (CYSLTR2) receptors. The leukotrienes are polyunsaturated lipoxygenated eicosatetraenoic acids that exhibit a wide range of pharmacological and physiological actions. Of the three enzymes involved in the formation of the leukotrienes, arachidonate 5 lipoxygenase 5 (ALOX5), leukotriene C4 synthase (LTC4S), and leukotriene hydrolase (LTA4H) are all polymorphic. These polymorphisms often result in variable production of the CysLTs (LTC4, LTD4, and LTE4) and LTB4. Variable tandem repeat (VNTR) sequences located in the Sp1-binding motif within the promotor region of the ALOX5 gene are associated with leukotriene burden and bronchoconstriction independent of asthma risk. A 444A>C SNP polymorphism in the LTC4S gene, encoding an enzyme required for the formation of a glutathione adduct at the C-6 position of the arachidonic acid backbone, is associated with severe asthma and altered response to the CYSLTR1 receptor antagonist zafirlukast. Genetic variability in the CysLT pathway may contribute additively or synergistically to altered drug responses. The 601 A>G variant of the CYSLTR2 gene, encoding the Met201Val CYSLTR2 receptor variant, is associated with atopic asthma in the general European population, where it is present at a frequency of ~2.6%. The variant was originally found in the founder population of Tristan da Cunha, a remote island in the South Atlantic, in which the prevalence of atopy is approximately 45% and the prevalence of asthma is 36%. In vitro work showed that the atopy-associated Met201Val variant was inactivating with respect to ligand binding, Ca2+ flux and inositol phosphate (IP) generation. In addition, the CYSLTR1 gene, located at Xq13-21.1, has been associated with atopic asthma. The activating Gly300Ser CYSLTR1 variant is discussed. In addition to genetic loci, risk for asthma may be influenced by environmental factors such as smoking. The contribution of CysLT pathway gene sequence variants to atopic asthma is discussed in the context of other genes and environmental influences known to
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- 2016
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29. Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver
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López-Bermudo, Lucía, primary, Luque-Sierra, Amparo, additional, Maya-Miles, Douglas, additional, Gallego-Durán, Rocío, additional, Ampuero, Javier, additional, Romero-Gómez, Manuel, additional, Berná, Genoveva, additional, and Martín, Franz, additional
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- 2022
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30. Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
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Universidad de Sevilla. Departamento de Medicina, Gallego Durán, Rocío, Ampuero Herrojo, Javier, Pastor Ramírez, Helena, Álvarez Amor, Leticia, Campo, José Antonio del, Maya Miles, Douglas, Muñoz Hernández, Rocío, Romero Gómez, Manuel, Universidad de Sevilla. Departamento de Medicina, Gallego Durán, Rocío, Ampuero Herrojo, Javier, Pastor Ramírez, Helena, Álvarez Amor, Leticia, Campo, José Antonio del, Maya Miles, Douglas, Muñoz Hernández, Rocío, and Romero Gómez, Manuel
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The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD patients were genotyped for rs1047891, a functional variant located in carbamoyl phosphate synthetase-1 (CPS1) gene. Two preclinical models were employed to analyse CPS1 by immunohistochemistry, a choline deficient high-fat diet model (CDA-HFD) and a high fat diet LDLr knockout model (LDLr −/−). A significant downregulation in mRNA was observed in CPS1 and ornithine transcarbamylase (OTC1) in simple steatosis and NASH-fibrosis patients versus controls. Further, age, obesity (BMI > 30 kg/m2), diabetes mellitus and ALT were found to be risk factors whereas A-allele from CPS1 was a protective factor from liver fibrosis. CPS1 hepatic expression was diminished in parallel with the increase of fibrosis, and its levels reverted up to normality after changing diet in CDA-HFD mice. In conclusion, liver fibrosis and steatosis were associated with a reduction in both gene and protein expression patterns of mitochondrial urea cycle enzymes. A-allele from a variant on CPS1 may protect from fibrosis development. CPS1 expression is restored in a preclinical model when the main trigger of the liver damage disappears.
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- 2022
31. Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD
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Universidad de Sevilla. Departamento de Medicina, Ampuero Herrojo, Javier, Gallego Durán, Rocío, Maya Miles, Douglas, Montero, Rocío, Gato, Sheila, Rojas, Ángela, Gil, Antonio, Muñoz, Rocío, Romero Gómez, Manuel, Universidad de Sevilla. Departamento de Medicina, Ampuero Herrojo, Javier, Gallego Durán, Rocío, Maya Miles, Douglas, Montero, Rocío, Gato, Sheila, Rojas, Ángela, Gil, Antonio, Muñoz, Rocío, and Romero Gómez, Manuel
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Background NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment versus placebo by carrying out a meta-analysis of NAFLD clinical trials. Methods After a systematic review of NAFLD clinical trials to May 2021, applying strict selection criteria, the following primary outcomes were observed: (a) NASH resolution, with no worsening of fibrosis when available; (b) fibrosis improvement ≥ 1 stage, with no worsening of NAS when available; (c) worsening of NAS; (d) worsening of liver fibrosis ≥ 1 stage, including the progression to cirrhosis on histopathology. Other histological, clinical, and biochemical outcomes were considered secondary endpoints. Heterogeneity was explored by subgroup and sensitivity analyses, and univariable meta-regression. Results Twenty-seven randomized clinical trials were included. The pooled efficacy for NASH resolution receiving experimental therapy was 19% (95%CI 15–23; I2 96.2%) compared with placebo 10% (95%CI 7–12; I2 85.8%) (OR 1.66 (95%CI 1.24–2.21); I2 57.8%), while it was 26% (95%CI 22–29); I2 90%)) versus 18% (95%CI 15–21; I2 59%)) for fibrosis improvement (OR 1.34 (95%CI 1.13–1.58); I2 25.4%). For these outcomes, the therapy showed higher efficacy in trials longer than 48 weeks, with < 60% of diabetic population, and when it targeted FXR, PPAR, and antidiabetic mechanisms, and with a NAS < 5 for NASH resolution. Also, NASH (OR 0.57 (95%CI 0.39–0.84); I2 67%) and fibrosis worsening (OR 0.65 (95%CI 0.46–0.92); I2 61.9%) were prevented with the therapy. Conclusion This meta-analysis provides information about the efficacy of the therapy versus placebo by comparing different and combined trial outcomes such as NASH resolution, fibrosis improvement, and NAS and fibrosis worsening. Changes in the experimental design and selection criteria of the clinical trials might be suitable to
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- 2022
32. Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
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Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. Departamento de Fisiología, Consejería de Salud, Junta de Andalucía, Ministerio de Ciencia e Innovación, Junta de Andalucía, Gil Gómez, Antonio, Rojas, Ángela, García Lozano, María R., Muñoz Hernández, Rocío, Gallego-Durán, Rocío, Maya Miles, Douglas, Ampuero Herrojo, Javier, Romero Gómez, Manuel, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. Departamento de Fisiología, Consejería de Salud, Junta de Andalucía, Ministerio de Ciencia e Innovación, Junta de Andalucía, Gil Gómez, Antonio, Rojas, Ángela, García Lozano, María R., Muñoz Hernández, Rocío, Gallego-Durán, Rocío, Maya Miles, Douglas, Ampuero Herrojo, Javier, and Romero Gómez, Manuel
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A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced fibrosis and cirrhosis. In this study, we aimed to evaluate the prognosis of cirrhotic patients harboring this variant. We performed a retrospective analysis on 483 prospectively recruited patients from four different hospitals in Spain, followed-up for at least 5 years. We collected clinical, demographic, and biochemical data, and we performed a genotyping analysis for com mon variants previously associated with liver disease risk (HSD17B13 rs72613567:TA and PNPLA3 rs738409). Patients homozygous for the TA allele showed a higher MELD score (p = 0.047), Child– Turcotte–Pugh score (p = 0.014), and INR levels (p = 0.046), as well as decreased albumin (p = 0.004) at baseline. After multivariate analysis, patients with the “protective” variant indeed had an increased risk of hepatic decompensation [aHR 2.37 (1.09–5.06); p = 0.029] and liver-related mortality [aHR 2.32 (1.20–4.46); p = 0.012]. Specifically, these patients had an increased risk of developing ascites (Log-R 11.6; p < 0.001), hepatic encephalopathy (Log-R 10.2; p < 0.01), and higher mortality (Log-R 14.1; p < 0.001) at 5 years of follow-up. Interactions with the etiology of the cirrhosis and with the variant rs738409 in PNPLA3 are also described. These findings suggest that the variant rs72613567:TA in HSD17B13 has no protective effect, but indeed increases the risk of decompensation and death in patients with advanced chronic liver disease.
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- 2022
33. Novel genes and sex differences in COVID-19 severity
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Cruz, Raquel, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C, Pita, Guillermo, Lorenzo-Salazar, José M, González-Montelongo, Rafaela, Gago-Domínguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Nevado, Julian, Aguado, Jose María, Aguilar, Carlos, Aguilera-Albesa, Sergio, Almadana, Virginia, Almoguera, Berta, Alvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, Arango, Celso, Arranz, María J, Artiga, Maria-Jesus, Baptista-Rosas, Raúl C, Barreda-Sánchez, María, Belhassen-Garcia, Moncef, Bezerra, Joao F, Bezerra, Marcos A C, Boix-Palop, Lucía, Brion, María, Brugada, Ramón, Bustos, Matilde, Calderón, Enrique J, Carbonell, Cristina, Castano, Luis, Castelao, Jose E, Conde-Vicente, Rosa, Cordero-Lorenzana, M Lourdes, Cortes-Sanchez, Jose L, Corton, Marta, Darnaude, M Teresa, De Martino-Rodríguez, Alba, Del Campo-Pérez, Victor, Diaz de Bustamante, Aranzazu, Domínguez-Garrido, Elena, Luchessi, Andre D, Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Carmen Fariñas, María, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gil-Fournier, Belén, Gómez-Arrue, Javier, González Álvarez, Beatriz, Gonzalez Bernaldo de Quirós, Fernan, González-Peñas, Javier, Gutiérrez-Bautista, Juan F, Herrero, María José, Herrero-Gonzalez, Antonio, Jimenez-Sousa, María A, Lattig, María Claudia, Liger Borja, Anabel, Lopez-Rodriguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martinez-Nieto, Oscar, Martinez-Lopez, Iciar, Martinez-Resendez, Michel F, Martinez-Perez, Angel, Mazzeu, Juliana F, Merayo Macías, Eleuterio, Minguez, Pablo, Moreno Cuerda, Victor, Silbiger, Vivian N, Oliveira, Silviene F, Ortega-Paino, Eva, Parellada, Mara, Paz-Artal, Estela, Santos, Ney P C, Pérez-Matute, Patricia, Perez, Patricia, Pérez-Tomás, M Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N, Porras-Hurtado, Gloria L, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R, Rodríguez-Ruiz, Emilio, Rodriguez-Artalejo, Fernando, Rodriguez-Garcia, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Tamayo, Eduardo, Tamayo-Velasco, Alvaro, Taracido-Fernandez, Juan Carlos, Teper, Alejandro, Torres-Tobar, Lilian, Urioste, Miguel, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Amitrano, Sara, Roade, Luisa, Fava, Francesca, Spinner, Christoph D, Prati, Daniele, Bernardo, David, Garcia, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesus M, Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C, Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R, Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M, Ludwig, Kerstin U, Buti, Maria, Rahmouni, Souad, Alarcón-Riquelme, Marta E, Schulte, Eva C, Franke, Andre, Karlsen, Tom H, Valenti, Luca, Zeberg, Hugo, Richards, Brent, Ganna, Andrea, Boada, Mercè, de Rojas, Itziar, Ruiz, Agustín, Sánchez-Juan, Pascual, Real, Luis Miguel, Guillen-Navarro, Encarna, Ayuso, Carmen, González-Neira, Anna, Riancho, José A, Rojas-Martinez, Augusto, Flores, Carlos, Lapunzina, Pablo, Carracedo, Angel, Cruz, Raquel, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C, Pita, Guillermo, Lorenzo-Salazar, José M, González-Montelongo, Rafaela, Gago-Domínguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Nevado, Julian, Aguado, Jose María, Aguilar, Carlos, Aguilera-Albesa, Sergio, Almadana, Virginia, Almoguera, Berta, Alvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, Arango, Celso, Arranz, María J, Artiga, Maria-Jesus, Baptista-Rosas, Raúl C, Barreda-Sánchez, María, Belhassen-Garcia, Moncef, Bezerra, Joao F, Bezerra, Marcos A C, Boix-Palop, Lucía, Brion, María, Brugada, Ramón, Bustos, Matilde, Calderón, Enrique J, Carbonell, Cristina, Castano, Luis, Castelao, Jose E, Conde-Vicente, Rosa, Cordero-Lorenzana, M Lourdes, Cortes-Sanchez, Jose L, Corton, Marta, Darnaude, M Teresa, De Martino-Rodríguez, Alba, Del Campo-Pérez, Victor, Diaz de Bustamante, Aranzazu, Domínguez-Garrido, Elena, Luchessi, Andre D, Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Carmen Fariñas, María, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gil-Fournier, Belén, Gómez-Arrue, Javier, González Álvarez, Beatriz, Gonzalez Bernaldo de Quirós, Fernan, González-Peñas, Javier, Gutiérrez-Bautista, Juan F, Herrero, María José, Herrero-Gonzalez, Antonio, Jimenez-Sousa, María A, Lattig, María Claudia, Liger Borja, Anabel, Lopez-Rodriguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martinez-Nieto, Oscar, Martinez-Lopez, Iciar, Martinez-Resendez, Michel F, Martinez-Perez, Angel, Mazzeu, Juliana F, Merayo Macías, Eleuterio, Minguez, Pablo, Moreno Cuerda, Victor, Silbiger, Vivian N, Oliveira, Silviene F, Ortega-Paino, Eva, Parellada, Mara, Paz-Artal, Estela, Santos, Ney P C, Pérez-Matute, Patricia, Perez, Patricia, Pérez-Tomás, M Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N, Porras-Hurtado, Gloria L, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R, Rodríguez-Ruiz, Emilio, Rodriguez-Artalejo, Fernando, Rodriguez-Garcia, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Tamayo, Eduardo, Tamayo-Velasco, Alvaro, Taracido-Fernandez, Juan Carlos, Teper, Alejandro, Torres-Tobar, Lilian, Urioste, Miguel, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Pigazzini, Sara, Degenhardt, Frauke, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Amitrano, Sara, Roade, Luisa, Fava, Francesca, Spinner, Christoph D, Prati, Daniele, Bernardo, David, Garcia, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Holter, Jan Cato, Banales, Jesus M, Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C, Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R, Migeotte, Isabelle, Renieri, Alessandra, Planas, Anna M, Ludwig, Kerstin U, Buti, Maria, Rahmouni, Souad, Alarcón-Riquelme, Marta E, Schulte, Eva C, Franke, Andre, Karlsen, Tom H, Valenti, Luca, Zeberg, Hugo, Richards, Brent, Ganna, Andrea, Boada, Mercè, de Rojas, Itziar, Ruiz, Agustín, Sánchez-Juan, Pascual, Real, Luis Miguel, Guillen-Navarro, Encarna, Ayuso, Carmen, González-Neira, Anna, Riancho, José A, Rojas-Martinez, Augusto, Flores, Carlos, Lapunzina, Pablo, and Carracedo, Angel
- Abstract
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
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- 2022
- Full Text
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34. Detailed stratified GWAS analysis for severe COVID-19 in four European populations
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Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. Departamento de Enfermería, Consejería de Salud, Junta de Andalucía, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Instituto de Salud Carlos III, Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga Jaso, Jon, Wendorff, Mareike, Maya Miles, Douglas, Calderón Sandubete, Enrique José, Morilla Romero de la Osa, Rubén, Franke, Andre, Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. Departamento de Enfermería, Consejería de Salud, Junta de Andalucía, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Instituto de Salud Carlos III, Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga Jaso, Jon, Wendorff, Mareike, Maya Miles, Douglas, Calderón Sandubete, Enrique José, Morilla Romero de la Osa, Rubén, and Franke, Andre
- Abstract
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi organ involvement. This entity has displaced viral hepatitis as the main cause of severe forms of hepatic diseases, although the onset and transition of MAFLD stages still remains unclear. Nevertheless, innate and adaptive immune responses seem to play an essential role in the establishment and further progression of this disease. The immune system is responsible of safeguard and preserves organs and systems function, and might be altered under different stimuli. Thus, the liver suffers from metabolic and immune changes leading to different injuries and loss of function. It has been stablished that cell-cell crosstalk is a key process in the hepatic homeostasis maintenance. There is mounting evidence suggesting that MAFLD pathogenesis is determined by a complex interaction of environmental, genetic and host factors that leads to a full plethora of outcomes. Therefore, herein we will revisit and discuss the interplay between immune mechanisms and MAFLD, highlighting the potential role of immunological markers in an attempt to clarify its relationship.
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- 2022
35. Supplementary files of the article 'Novel genes and sex differences in COVID-19 severity' [Dataset]
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Cruz Modino, Raquel de la, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C., Pita, Guillermo, Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Gago-Dominguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Carbonell, Cristina, Migeotte, Isabelle, Renieri, Alessandra, Aguilera-Albesa, Sergio, Planas, Anna M., Ludwig, Kerstin U., Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Tamayo-Velasco, Álvaro, Franke, Andre, Castaño, Luis, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Almadana Pacheco, Virginia, Richards, Brent, Ganna, Andrea, Boada, Mercè, Rojas, Itziar de, Gil-Fournier, Belén, Ruiz, Agustín, Sánchez-Juan, Pascual, Castelao, Jose E., Real, Luis Miguel, SCOURGE Cohort Group, HOSTAGE Cohort Group, GRA@CE Cohort Group, Almoguera, Berta, Guillen-Navarro, Encarna, Ayuso, Carmen, Gómez-Arrue, Javier, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Conde-Vicente, Rosa, Flores, Carlos, Lapunzina, Pablo, Carracedo, Ángel, Álvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, González Álvarez, Beatriz, Arango, Celso, Arranz, Maria J., Artiga, María Jesús, Baptista-Rosas, Raúl C., Cordero-Lorenzana, M. Lourdes, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F., Bezerra, Marcos A. C., Boix-Palop, Lucía, Gonzalez Bernaldo de Quirós, Fernán, Briones, María, Brugada, Ramón, Bustos, Matilde, Cortés-Sánchez, José L., Cortón, Marta, Darnaude, M. Teresa, Martino-Rodríguez, Alba de, Tamayo, Eduardo, Campo-Pérez, Víctor de, Diaz de Bustamante, Aranzazu, González-Peñas, Javier, Domínguez-Garrido, Elena, Luchessi, Andre D., Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Fariñas, María del Carmen, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gutiérrez-Bautista, Juan F., Herrero, María José, Herrero-Gonzalez, Antonio, Jiménez-Sousa, María A., Aguado, José María, Lattig, María Claudia, Taracido-Fernandez, Juan Carlos, Liger Borja, Anabel, López-Rodríguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martínez-Nieto, Oscar, Martinez-López, Icíar, Martinez-Resendez, Michel F., Amitrano, Sara, Martínez-Pérez, Àngel, Mazzeu, Juliana F, Teper, Alejandro, Merayo Macías, Eleuterio, Mínguez, Pablo, Moreno Cuerda, Víctor, Silbiger, Vivian N., Oliveira, Silviene F., Ortega-Paino, Eva, Parellada, Mara, Roade, Luisa, Paz-Artal, Estela, Santos, Ney P. C., Pérez-Matute, Patricia, Torres-Tobar, Lilian, Pérez Ramírez, Patricia, Pérez-Tomás, M. Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N., Porras-Hurtado, Gloria L., Fava, Francesca, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R., Urioste, Miguel, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodríguez-García, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Spinner, Christoph D., Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Nevado, Julian, Pigazzini, Sara, Degenhardt, Frauke, Prati, Daniele, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Calderón, Enrique J., Holter, Jan Cato, Aguilar, Carlos, Banales, Jesús M., Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R., Cruz Modino, Raquel de la, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C., Pita, Guillermo, Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Gago-Dominguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Carbonell, Cristina, Migeotte, Isabelle, Renieri, Alessandra, Aguilera-Albesa, Sergio, Planas, Anna M., Ludwig, Kerstin U., Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Tamayo-Velasco, Álvaro, Franke, Andre, Castaño, Luis, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Almadana Pacheco, Virginia, Richards, Brent, Ganna, Andrea, Boada, Mercè, Rojas, Itziar de, Gil-Fournier, Belén, Ruiz, Agustín, Sánchez-Juan, Pascual, Castelao, Jose E., Real, Luis Miguel, SCOURGE Cohort Group, HOSTAGE Cohort Group, GRA@CE Cohort Group, Almoguera, Berta, Guillen-Navarro, Encarna, Ayuso, Carmen, Gómez-Arrue, Javier, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Conde-Vicente, Rosa, Flores, Carlos, Lapunzina, Pablo, Carracedo, Ángel, Álvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, González Álvarez, Beatriz, Arango, Celso, Arranz, Maria J., Artiga, María Jesús, Baptista-Rosas, Raúl C., Cordero-Lorenzana, M. Lourdes, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F., Bezerra, Marcos A. C., Boix-Palop, Lucía, Gonzalez Bernaldo de Quirós, Fernán, Briones, María, Brugada, Ramón, Bustos, Matilde, Cortés-Sánchez, José L., Cortón, Marta, Darnaude, M. Teresa, Martino-Rodríguez, Alba de, Tamayo, Eduardo, Campo-Pérez, Víctor de, Diaz de Bustamante, Aranzazu, González-Peñas, Javier, Domínguez-Garrido, Elena, Luchessi, Andre D., Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Fariñas, María del Carmen, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gutiérrez-Bautista, Juan F., Herrero, María José, Herrero-Gonzalez, Antonio, Jiménez-Sousa, María A., Aguado, José María, Lattig, María Claudia, Taracido-Fernandez, Juan Carlos, Liger Borja, Anabel, López-Rodríguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martínez-Nieto, Oscar, Martinez-López, Icíar, Martinez-Resendez, Michel F., Amitrano, Sara, Martínez-Pérez, Àngel, Mazzeu, Juliana F, Teper, Alejandro, Merayo Macías, Eleuterio, Mínguez, Pablo, Moreno Cuerda, Víctor, Silbiger, Vivian N., Oliveira, Silviene F., Ortega-Paino, Eva, Parellada, Mara, Roade, Luisa, Paz-Artal, Estela, Santos, Ney P. C., Pérez-Matute, Patricia, Torres-Tobar, Lilian, Pérez Ramírez, Patricia, Pérez-Tomás, M. Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N., Porras-Hurtado, Gloria L., Fava, Francesca, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R., Urioste, Miguel, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodríguez-García, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Spinner, Christoph D., Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Nevado, Julian, Pigazzini, Sara, Degenhardt, Frauke, Prati, Daniele, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Calderón, Enrique J., Holter, Jan Cato, Aguilar, Carlos, Banales, Jesús M., Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, and Hov, Johannes R.
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- 2022
36. Detailed stratified GWAS analysis for severe COVID-19 in four European populations
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Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga-Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, Rühlemann, Malte C, Arora, Jatin, Özer, Onur, Lenning, Ole Bernt, Myhre, Ronny, Vadla, May Sissel, Wacker, Eike M, Wienbrandt, Lars, Ortiz, Aaron Blandino, Salazar, Adolfo, Chercoles, Adolfo Garrido, Palom, Adriana, Ruiz, Agustín, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Zanella, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Nebel, Almut, Barreira, Ana, Lleo, Ana, Teles, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Ganna, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Hinney, Anke, Jensen, Björn, Banasik, Karina, Castro, Pedro, Brunak, Søren, Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga-Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, Rühlemann, Malte C, Arora, Jatin, Özer, Onur, Lenning, Ole Bernt, Myhre, Ronny, Vadla, May Sissel, Wacker, Eike M, Wienbrandt, Lars, Ortiz, Aaron Blandino, Salazar, Adolfo, Chercoles, Adolfo Garrido, Palom, Adriana, Ruiz, Agustín, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Zanella, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Nebel, Almut, Barreira, Ana, Lleo, Ana, Teles, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Ganna, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Hinney, Anke, Jensen, Björn, Banasik, Karina, Castro, Pedro, and Brunak, Søren
- Abstract
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
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- 2022
37. Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD
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Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Junta de Andalucía, Ministerio de Ciencia e Innovación (España), Ampuero, Javier, Gallego-Durán, Rocío, Maya-Miles, Douglas, Montero, Rocío, Gato, Sheila, Rojas, Ángela, Gil, Antonio, Muñoz, Rocío, Romero-Gómez, Manuel, Conferencia de Rectores de las Universidades Españolas, Consejo Superior de Investigaciones Científicas (España), Junta de Andalucía, Ministerio de Ciencia e Innovación (España), Ampuero, Javier, Gallego-Durán, Rocío, Maya-Miles, Douglas, Montero, Rocío, Gato, Sheila, Rojas, Ángela, Gil, Antonio, Muñoz, Rocío, and Romero-Gómez, Manuel
- Abstract
[Background] NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment versus placebo by carrying out a meta-analysis of NAFLD clinical trials., [Methods] After a systematic review of NAFLD clinical trials to May 2021, applying strict selection criteria, the following primary outcomes were observed: (a) NASH resolution, with no worsening of fibrosis when available; (b) fibrosis improvement ≥ 1 stage, with no worsening of NAS when available; (c) worsening of NAS; (d) worsening of liver fibrosis ≥ 1 stage, including the progression to cirrhosis on histopathology. Other histological, clinical, and biochemical outcomes were considered secondary endpoints. Heterogeneity was explored by subgroup and sensitivity analyses, and univariable meta-regression., [Results] Twenty-seven randomized clinical trials were included. The pooled efficacy for NASH resolution receiving experimental therapy was 19% (95%CI 15–23; I2 96.2%) compared with placebo 10% (95%CI 7–12; I2 85.8%) (OR 1.66 (95%CI 1.24–2.21); I2 57.8%), while it was 26% (95%CI 22–29); I2 90%)) versus 18% (95%CI 15–21; I2 59%)) for fibrosis improvement (OR 1.34 (95%CI 1.13–1.58); I2 25.4%). For these outcomes, the therapy showed higher efficacy in trials longer than 48 weeks, with < 60% of diabetic population, and when it targeted FXR, PPAR, and antidiabetic mechanisms, and with a NAS < 5 for NASH resolution. Also, NASH (OR 0.57 (95%CI 0.39–0.84); I2 67%) and fibrosis worsening (OR 0.65 (95%CI 0.46–0.92); I2 61.9%) were prevented with the therapy., [Conclusion] This meta-analysis provides information about the efficacy of the therapy versus placebo by comparing different and combined trial outcomes such as NASH resolution, fibrosis improvement, and NAS and fibrosis worsening. Changes in the experimental design and selection criteria of the clinical trials might be suitable to increase the efficacy.
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- 2022
38. Long non-coding RNA H19 as a biomarker for hepatocellular carcinoma
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Junta de Andalucía, Instituto de Salud Carlos III, Gallego-Durán, Rocío [0000-0002-9452-1661], Muntané, Jordi [0000-0002-6744-1121], Ampuero, Javier [0000-0002-8332-2122], Romero-Gómez, Manuel [0000-0001-8494-8947], Rojas, Ángela, Gil-Gómez, Antonio, Cruz, Patricia de la, Muñoz-Hernández, Rocío, Sánchez-Torrijos, Yolanda, Gallego-Durán, Rocío, Millán Domínguez, Raquel, Rico, María Carmen, Montero-Vallejo, Rocío, Gato, Sheila, Maya-Miles, Douglas, Ferrer-Ríos, María Teresa, Muntané, Jordi, Robles-Frías, María José, Ampuero, Javier, Padillo, Francisco J., Romero-Gómez, Manuel, Junta de Andalucía, Instituto de Salud Carlos III, Gallego-Durán, Rocío [0000-0002-9452-1661], Muntané, Jordi [0000-0002-6744-1121], Ampuero, Javier [0000-0002-8332-2122], Romero-Gómez, Manuel [0000-0001-8494-8947], Rojas, Ángela, Gil-Gómez, Antonio, Cruz, Patricia de la, Muñoz-Hernández, Rocío, Sánchez-Torrijos, Yolanda, Gallego-Durán, Rocío, Millán Domínguez, Raquel, Rico, María Carmen, Montero-Vallejo, Rocío, Gato, Sheila, Maya-Miles, Douglas, Ferrer-Ríos, María Teresa, Muntané, Jordi, Robles-Frías, María José, Ampuero, Javier, Padillo, Francisco J., and Romero-Gómez, Manuel
- Abstract
[Background and Aims] Liver cancer stem cells (CSCs) could be involved in the carcinogenesis, recurrence, metastasis and chemoresistance of hepatocellular carcinoma (HCC). The aim of this study was to explore the role of lncRNA-H19 as a biomarker for liver cancer., [Methods] LncRNA-H19 expression levels and the functional assays were conducted in EpCAM+CD133+ CSCs and C57BL/6J mice fed with a high-fat high-cholesterol carbohydrate (HFHCC) or standard diet for 52 weeks. Liver tissue and plasma samples from patients with cirrhosis, with or without HCC, were used for the analyses of gene expression and circulating lncRNA-H19 levels in an estimation and validation cohort., [Results] EpCAM+CD133+ cells showed a stem cell-like phenotype, self-renewal capacity, upregulation of pluripotent gene expression and overexpressed lncRNA-H19 (p < .001). Suppression of lncRNA-H19 by antisense oligonucleotide treatment significantly reduced the self-renewal capacity (p < .001). EpCAM, CD133 and lncRNA-h19 expression increased accordingly with disease progression in HFHCC-fed mice (p < .05) and also in liver tissue from HCC patients (p = .0082). Circulating lncRNA-H19 levels were significantly increased in HCC patients in both cohorts (p = .013; p < .0001). In addition, lncRNA-H19 levels increased accordingly with BCLC staging (p < .0001) and decreased after a partial and complete therapeutic response (p < .05). In addition, patients with cirrhosis who developed HCC during follow-up showed higher lncRNA-H19 levels (p = .0025)., [Conclusion] LncRNA-H19 expression was increased in CSCs, in liver tissue and plasma of patients with HCC and decreased after partial/complete therapeutic response. Those patients who developed HCC during the follow-up showed higher levels of lncRNA-H19. LncRNA-H19 could constitute a new biomarker of HCC.
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- 2022
39. Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic Decompensation and Mortality in Cirrhotic Patients
- Author
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Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Gil-Gómez, Antonio [0000-0001-9622-1761], Rojas, Ángela [0000-0003-0853-4800], García-Lozano, María del Rosario [0000-0002-6255-4960], Muñoz-Hernández, Rocío [0000-0003-3765-6276], Gato, Sheila0000-0002-4141-4897, Francés, Rubén0000-0001-5105-1201, Soriano, Germán0000-0002-9267-6811, Romero-Gómez, Manuel [0000-0001-8494-8947], Gil-Gómez, Antonio, Rojas, Ángela, García-Lozano, María del Rosario, Muñoz-Hernández, Rocío, Gallego-Durán, Rocío, Maya-Miles, Douglas, Montero-Vallejo, Rocío, Gato, Sheila, Gallego, Javier, Francés, Rubén, Soriano, Germán, Ampuero, Javier, Romero-Gómez, Manuel, Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Gil-Gómez, Antonio [0000-0001-9622-1761], Rojas, Ángela [0000-0003-0853-4800], García-Lozano, María del Rosario [0000-0002-6255-4960], Muñoz-Hernández, Rocío [0000-0003-3765-6276], Gato, Sheila0000-0002-4141-4897, Francés, Rubén0000-0001-5105-1201, Soriano, Germán0000-0002-9267-6811, Romero-Gómez, Manuel [0000-0001-8494-8947], Gil-Gómez, Antonio, Rojas, Ángela, García-Lozano, María del Rosario, Muñoz-Hernández, Rocío, Gallego-Durán, Rocío, Maya-Miles, Douglas, Montero-Vallejo, Rocío, Gato, Sheila, Gallego, Javier, Francés, Rubén, Soriano, Germán, Ampuero, Javier, and Romero-Gómez, Manuel
- Abstract
A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD patients and a reduced risk of progression to advanced fibrosis and cirrhosis. In this study, we aimed to evaluate the prognosis of cirrhotic patients harboring this variant. We performed a retrospective analysis on 483 prospectively recruited patients from four different hospitals in Spain, followed-up for at least 5 years. We collected clinical, demographic, and biochemical data, and we performed a genotyping analysis for common variants previously associated with liver disease risk (HSD17B13 rs72613567:TA and PNPLA3 rs738409). Patients homozygous for the TA allele showed a higher MELD score (p = 0.047), Child−Turcotte−Pugh score (p = 0.014), and INR levels (p = 0.046), as well as decreased albumin (p = 0.004) at baseline. After multivariate analysis, patients with the “protective” variant indeed had an increased risk of hepatic decompensation [aHR 2.37 (1.09−5.06); p = 0.029] and liver-related mortality [aHR 2.32 (1.20−4.46); p = 0.012]. Specifically, these patients had an increased risk of developing ascites (Log-R 11.6; p < 0.001), hepatic encephalopathy (Log-R 10.2; p < 0.01), and higher mortality (Log-R 14.1; p < 0.001) at 5 years of follow-up. Interactions with the etiology of the cirrhosis and with the variant rs738409 in PNPLA3 are also described. These findings suggest that the variant rs72613567:TA in HSD17B13 has no protective effect, but indeed increases the risk of decompensation and death in patients with advanced chronic liver disease.
- Published
- 2022
40. Novel genes and sex differences in COVID-19 severity
- Author
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Instituto de Salud Carlos III, European Commission, Fundación Amancio Ortega, Banco Santander, Estrella de Levante, Colabora Mujer, Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Cruz Modino, Raquel de la, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C., Pita, Guillermo, Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Gago-Dominguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Carbonell, Cristina, Migeotte, Isabelle, Renieri, Alessandra, Aguilera-Albesa, Sergio, Planas, Anna M., Ludwig, Kerstin U., Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Tamayo-Velasco, Álvaro, Franke, Andre, Castaño, Luis, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Almadana Pacheco, Virginia, Richards, Brent, Ganna, Andrea, Boada, Mercè, Rojas, Itziar de, Gil-Fournier, Belén, Ruiz, Agustín, Sánchez-Juan, Pascual, Castelao, Jose E., Real, Luis Miguel, SCOURGE Cohort Group, HOSTAGE Cohort Group, GRA@CE Cohort Group, Almoguera, Berta, Guillen-Navarro, Encarna, Ayuso, Carmen, Gómez-Arrue, Javier, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Conde-Vicente, Rosa, Flores, Carlos, Lapunzina, Pablo, Carracedo, Ángel, Álvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, González Álvarez, Beatriz, Arango, Celso, Arranz, Maria J., Artiga, María Jesús, Baptista-Rosas, Raúl C., Cordero-Lorenzana, M. Lourdes, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F., Bezerra, Marcos A. C., Boix-Palop, Lucía, Gonzalez Bernaldo de Quirós, Fernán, Briones, María, Brugada, Ramón, Bustos, Matilde, Cortés-Sánchez, José L., Cortón, Marta, Darnaude, M. Teresa, Martino-Rodríguez, Alba de, Tamayo, Eduardo, Campo-Pérez, Víctor de, Diaz de Bustamante, Aranzazu, González-Peñas, Javier, Domínguez-Garrido, Elena, Luchessi, Andre D., Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Fariñas, María del Carmen, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gutiérrez-Bautista, Juan F., Herrero, María José, Herrero-Gonzalez, Antonio, Jiménez-Sousa, María A., Aguado, José María, Lattig, María Claudia, Taracido-Fernandez, Juan Carlos, Liger Borja, Anabel, López-Rodríguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martínez-Nieto, Oscar, Martinez-López, Icíar, Martinez-Resendez, Michel F., Amitrano, Sara, Martínez-Pérez, Àngel, Mazzeu, Juliana F, Teper, Alejandro, Merayo Macías, Eleuterio, Mínguez, Pablo, Moreno Cuerda, Víctor, Silbiger, Vivian N., Oliveira, Silviene F., Ortega-Paino, Eva, Parellada, Mara, Roade, Luisa, Paz-Artal, Estela, Santos, Ney P. C., Pérez-Matute, Patricia, Torres-Tobar, Lilian, Pérez Ramírez, Patricia, Pérez-Tomás, M. Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N., Porras-Hurtado, Gloria L., Fava, Francesca, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R., Urioste, Miguel, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodríguez-García, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Spinner, Christoph D., Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Nevado, Julian, Pigazzini, Sara, Degenhardt, Frauke, Prati, Daniele, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Calderón, Enrique J., Holter, Jan Cato, Aguilar, Carlos, Banales, Jesús M., Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, Hov, Johannes R., Instituto de Salud Carlos III, European Commission, Fundación Amancio Ortega, Banco Santander, Estrella de Levante, Colabora Mujer, Fundación Canaria Instituto de Investigación Sanitaria de Canarias, Cruz Modino, Raquel de la, Diz-de Almeida, Silvia, López de Heredia, Miguel, Quintela, Inés, Ceballos, Francisco C., Pita, Guillermo, Lorenzo-Salazar, José M., González-Montelongo, Rafaela, Gago-Dominguez, Manuela, Sevilla Porras, Marta, Tenorio Castaño, Jair Antonio, Carbonell, Cristina, Migeotte, Isabelle, Renieri, Alessandra, Aguilera-Albesa, Sergio, Planas, Anna M., Ludwig, Kerstin U., Buti, María, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Schulte, Eva C., Tamayo-Velasco, Álvaro, Franke, Andre, Castaño, Luis, Karlsen, Tom H., Valenti, Luca, Zeberg, Hugo, Almadana Pacheco, Virginia, Richards, Brent, Ganna, Andrea, Boada, Mercè, Rojas, Itziar de, Gil-Fournier, Belén, Ruiz, Agustín, Sánchez-Juan, Pascual, Castelao, Jose E., Real, Luis Miguel, SCOURGE Cohort Group, HOSTAGE Cohort Group, GRA@CE Cohort Group, Almoguera, Berta, Guillen-Navarro, Encarna, Ayuso, Carmen, Gómez-Arrue, Javier, González-Neira, Anna, Riancho, José A., Rojas-Martinez, Augusto, Conde-Vicente, Rosa, Flores, Carlos, Lapunzina, Pablo, Carracedo, Ángel, Álvarez, Nuria, Andreu-Bernabeu, Álvaro, Arana-Arri, Eunate, González Álvarez, Beatriz, Arango, Celso, Arranz, Maria J., Artiga, María Jesús, Baptista-Rosas, Raúl C., Cordero-Lorenzana, M. Lourdes, Barreda-Sánchez, María, Belhassen-García, Moncef, Bezerra, Joao F., Bezerra, Marcos A. C., Boix-Palop, Lucía, Gonzalez Bernaldo de Quirós, Fernán, Briones, María, Brugada, Ramón, Bustos, Matilde, Cortés-Sánchez, José L., Cortón, Marta, Darnaude, M. Teresa, Martino-Rodríguez, Alba de, Tamayo, Eduardo, Campo-Pérez, Víctor de, Diaz de Bustamante, Aranzazu, González-Peñas, Javier, Domínguez-Garrido, Elena, Luchessi, Andre D., Eiros, Rocío, Estigarribia Sanabria, Gladys Mercedes, Fariñas, María del Carmen, Fernández-Robelo, Uxía, Fernández-Rodríguez, Amanda, Fernández-Villa, Tania, Gutiérrez-Bautista, Juan F., Herrero, María José, Herrero-Gonzalez, Antonio, Jiménez-Sousa, María A., Aguado, José María, Lattig, María Claudia, Taracido-Fernandez, Juan Carlos, Liger Borja, Anabel, López-Rodríguez, Rosario, Mancebo, Esther, Martín-López, Caridad, Martín, Vicente, Martínez-Nieto, Oscar, Martinez-López, Icíar, Martinez-Resendez, Michel F., Amitrano, Sara, Martínez-Pérez, Àngel, Mazzeu, Juliana F, Teper, Alejandro, Merayo Macías, Eleuterio, Mínguez, Pablo, Moreno Cuerda, Víctor, Silbiger, Vivian N., Oliveira, Silviene F., Ortega-Paino, Eva, Parellada, Mara, Roade, Luisa, Paz-Artal, Estela, Santos, Ney P. C., Pérez-Matute, Patricia, Torres-Tobar, Lilian, Pérez Ramírez, Patricia, Pérez-Tomás, M. Elena, Perucho, Teresa, Pinsach-Abuin, Mel Lina, Pompa-Mera, Ericka N., Porras-Hurtado, Gloria L., Fava, Francesca, Pujol, Aurora, Ramiro León, Soraya, Resino, Salvador, Fernandes, Marianne R., Urioste, Miguel, Rodríguez-Ruiz, Emilio, Rodríguez-Artalejo, Fernando, Rodríguez-García, José A, Ruiz Cabello, Francisco, Ruiz-Hornillos, Javier, Spinner, Christoph D., Ryan, Pablo, Soria, José Manuel, Souto, Juan Carlos, Valencia-Ramos, Juan, Yáñez, Zuleima, Zarate, Ruth, Nakanishi, Tomoko, Nevado, Julian, Pigazzini, Sara, Degenhardt, Frauke, Prati, Daniele, Butler-Laporte, Guillaume, Maya-Miles, Douglas, Bujanda, Luis, Bouysran, Youssef, Palom, Adriana, Ellinghaus, David, Martínez-Bueno, Manuel, Rolker, Selina, Bernardo, David, García, Federico, Darcis, Gilles, Fernández-Cadenas, Israel, Calderón, Enrique J., Holter, Jan Cato, Aguilar, Carlos, Banales, Jesús M., Frithiof, Robert, Duga, Stefano, Asselta, Rosanna, Pereira, Alexandre C., Romero-Gómez, Manuel, Nafría-Jiménez, Beatriz, and Hov, Johannes R.
- Abstract
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10-8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10-22 and P = 8.1 × 10-12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10-8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10-8) and ARHGAP33 (P = 1.3 × 10-8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10-8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.
- Published
- 2022
41. Detailed stratified GWAS analysis for severe COVID-19 in four European populations
- Author
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Degenhardt, F, Ellinghaus, D, Juzenas, S, Lerga-Jaso, J, Wendorff, M, Maya-Miles, D, Uellendahl-Werth, F, Elabd, H, Rühlemann, M, Arora, J, Özer, O, Lenning, O, Myhre, R, Vadla, M, Wacker, E, Wienbrandt, L, Ortiz, A, Salazar, A, Chercoles, A, Palom, A, Ruiz, A, Garcia-Fernandez, A, Blanco-Grau, A, Mantovani, A, Zanella, A, Holten, A, Mayer, A, Bandera, A, Cherubini, A, Protti, A, Aghemo, A, Gerussi, A, Ramirez, A, Braun, A, Nebel, A, Barreira, A, Lleo, A, Teles, A, Kildal, A, Biondi, A, Caballero-Garralda, A, Ganna, A, Gori, A, Glück, A, Lind, A, Tanck, A, Hinney, A, Nolla, A, Fracanzani, A, Peschuck, A, Cavallero, A, Dyrhol-Riise, A, Ruello, A, Julià, A, Muscatello, A, Pesenti, A, Voza, A, Rando-Segura, A, Solier, A, Schmidt, A, Cortes, B, Mateos, B, Nafria-Jimenez, B, Schaefer, B, Jensen, B, Bellinghausen, C, Maj, C, Ferrando, C, Horra, C, Quereda, C, Skurk, C, Thibeault, C, Scollo, C, Herr, C, Spinner, C, Gassner, C, Lange, C, Hu, C, Paccapelo, C, Lehmann, C, Angelini, C, Cappadona, C, Azuure, C, Bianco, C, Cea, C, Sancho, C, Hoff, D, Galimberti, D, Prati, D, Haschka, D, Jiménez, D, Pestaña, D, Toapanta, D, Muñiz-Diaz, E, Azzolini, E, Sandoval, E, Binatti, E, Scarpini, E, Helbig, E, Casalone, E, Urrechaga, E, Paraboschi, E, Pontali, E, Reverter, E, Calderón, E, Navas, E, Solligård, E, Contro, E, Arana-Arri, E, Aziz, F, Garcia, F, Sánchez, F, Ceriotti, F, Martinelli-Boneschi, F, Peyvandi, F, Kurth, F, Blasi, F, Malvestiti, F, Medrano, F, Mesonero, F, Rodriguez-Frias, F, Hanses, F, Müller, F, Hemmrich-Stanisak, G, Bellani, G, Grasselli, G, Pezzoli, G, Costantino, G, Albano, G, Cardamone, G, Bellelli, G, Citerio, G, Foti, G, Lamorte, G, Matullo, G, Baselli, G, Kurihara, H, Neb, H, My, I, Kurth, I, Hernández, I, Pink, I, Rojas, I, Galván-Femenia, I, Holter, J, Afset, J, Heyckendorf, J, Kässens, J, Damås, J, Rybniker, J, Altmüller, J, Ampuero, J, Martín, J, Erdmann, J, Banales, J, Badia, J, Dopazo, J, Schneider, J, Bergan, J, Barretina, J, Walter, J, Quero, J, Goikoetxea, J, Delgado, J, Guerrero, J, Fazaal, J, Kraft, J, Schröder, J, Risnes, K, Banasik, K, Müller, K, Gaede, K, Garcia-Etxebarria, K, Tonby, K, Heggelund, L, Izquierdo-Sanchez, L, Bettini, L, Sumoy, L, Sander, L, Lippert, L, Terranova, L, Nkambule, L, Knopp, L, Gustad, L, Garbarino, L, Santoro, L, Téllez, L, Roade, L, Ostadreza, M, Intxausti, M, Kogevinas, M, Riveiro-Barciela, M, Berger, M, Schaefer, M, Niemi, M, Gutiérrez-Stampa, M, Carrabba, M, Figuera Basso, M, Valsecchi, M, Hernandez-Tejero, M, Vehreschild, M, Manunta, M, Acosta-Herrera, M, D'Angiò, M, Baldini, M, Cazzaniga, M, Grimsrud, M, Cornberg, M, Nöthen, M, Marquié, M, Castoldi, M, Cordioli, M, Cecconi, M, D'Amato, M, Augustin, M, Tomasi, M, Boada, M, Dreher, M, Seilmaier, M, Joannidis, M, Wittig, M, Mazzocco, M, Ciccarelli, M, Rodríguez-Gandía, M, Bocciolone, M, Miozzo, M, Ayo, N, Blay, N, Chueca, N, Montano, N, Braun, N, Ludwig, N, Marx, N, Martínez, N, Cornely, O, Witzke, O, Palmieri, O, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Tentorio, P, Castro, P, Rodrigues, P, España, P, Hoffmann, P, Rosenstiel, P, Schommers, P, Suwalski, P, Pablo, R, Ferrer, R, Bals, R, Gualtierotti, R, Gallego-Durán, R, Nieto, R, Carpani, R, Morilla, R, Badalamenti, S, Haider, S, Ciesek, S, May, S, Bombace, S, Marsal, S, Pigazzini, S, Klein, S, Pelusi, S, Wilfling, S, Bosari, S, Volland, S, Brunak, S, Raychaudhuri, S, Schreiber, S, Heilmann-Heimbach, S, Aliberti, S, Ripke, S, Dudman, S, Wesse, T, Zheng, T, Bahmer, T, Eggermann, T, Illig, T, Brenner, T, Pumarola, T, Feldt, T, Folseraas, T, Cejudo, T, Landmesser, U, Protzer, U, Hehr, U, Rimoldi, V, Monzani, V, Skogen, V, Keitel, V, Kopfnagel, V, Friaza, V, Andrade, V, Moreno, V, Albrecht, W, Peter, W, Poller, W, Farre, X, Yi, X, Wang, X, Khodamoradi, Y, Karadeniz, Z, Latiano, A, Goerg, S, Bacher, P, Koehler, P, Tran, F, Zoller, H, Schulte, E, Heidecker, B, Ludwig, K, Fernández, J, Romero-Gómez, M, Albillos, A, Invernizzi, P, Buti, M, Duga, S, Bujanda, L, Hov, J, Lenz, T, Asselta, R, Cid, R, Valenti, L, Karlsen, T, Cáceres, M, Franke, A, Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga-Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, Rühlemann, Malte C, Arora, Jatin, Özer, Onur, Lenning, Ole Bernt, Myhre, Ronny, Vadla, May Sissel, Wacker, Eike M, Wienbrandt, Lars, Ortiz, Aaron Blandino, Salazar, Adolfo, Chercoles, Adolfo Garrido, Palom, Adriana, Ruiz, Agustín, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Zanella, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Nebel, Almut, Barreira, Ana, Lleo, Ana, Teles, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Ganna, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Tanck, Anja, Hinney, Anke, Nolla, Anna Carreras, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, Julià, Antonio, Muscatello, Antonio, Pesenti, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Schmidt, Axel, Cortes, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Jensen, Björn, Bellinghausen, Carla, Maj, Carlo, Ferrando, Carlos, Horra, Carmen, Quereda, Carmen, Skurk, Carsten, Thibeault, Charlotte, Scollo, Chiara, Herr, Christian, Spinner, Christoph D, Gassner, Christoph, Lange, Christoph, Hu, Cinzia, Paccapelo, Cinzia, Lehmann, Clara, Angelini, Claudio, Cappadona, Claudio, Azuure, Clinton, Bianco, Cristiana, Cea, Cristina, Sancho, Cristina, Hoff, Dag Arne Lihaug, Galimberti, Daniela, Prati, Daniele, Haschka, David, Jiménez, David, Pestaña, David, Toapanta, David, Muñiz-Diaz, Eduardo, Azzolini, Elena, Sandoval, Elena, Binatti, Eleonora, Scarpini, Elio, Helbig, Elisa T, Casalone, Elisabetta, Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, Calderón, Enrique J, Navas, Enrique, Solligård, Erik, Contro, Ernesto, Arana-Arri, Eunate, Aziz, Fátima, Garcia, Federico, Sánchez, Félix García, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Kurth, Florian, Blasi, Francesco, Malvestiti, Francesco, Medrano, Francisco J, Mesonero, Francisco, Rodriguez-Frias, Francisco, Hanses, Frank, Müller, Fredrik, Hemmrich-Stanisak, Georg, Bellani, Giacomo, Grasselli, Giacomo, Pezzoli, Gianni, Costantino, Giorgio, Albano, Giovanni, Cardamone, Giulia, Bellelli, Giuseppe, Citerio, Giuseppe, Foti, Giuseppe, Lamorte, Giuseppe, Matullo, Giuseppe, Baselli, Guido, Kurihara, Hayato, Neb, Holger, My, Ilaria, Kurth, Ingo, Hernández, Isabel, Pink, Isabell, Rojas, Itziar, Galván-Femenia, Iván, Holter, Jan Cato, Afset, Jan Egil, Heyckendorf, Jan, Kässens, Jan, Damås, Jan Kristian, Rybniker, Jan, Altmüller, Janine, Ampuero, Javier, Martín, Javier, Erdmann, Jeanette, Banales, Jesus M, Badia, Joan Ramon, Dopazo, Joaquin, Schneider, Jochen, Bergan, Jonas, Barretina, Jordi, Walter, Jörn, Quero, Jose Hernández, Goikoetxea, Josune, Delgado, Juan, Guerrero, Juan M, Fazaal, Julia, Kraft, Julia, Schröder, Julia, Risnes, Kari, Banasik, Karina, Müller, Karl Erik, Gaede, Karoline I, Garcia-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lars, Izquierdo-Sanchez, Laura, Bettini, Laura Rachele, Sumoy, Lauro, Sander, Leif Erik, Lippert, Lena J, Terranova, Leonardo, Nkambule, Lindokuhle, Knopp, Lisa, Gustad, Lise Tuset, Garbarino, Lucia, Santoro, Luigi, Téllez, Luis, Roade, Luisa, Ostadreza, Mahnoosh, Intxausti, Maider, Kogevinas, Manolis, Riveiro-Barciela, Mar, Berger, Marc M, Schaefer, Marco, Niemi, Mari E K, Gutiérrez-Stampa, María A, Carrabba, Maria, Figuera Basso, Maria E, Valsecchi, Maria Grazia, Hernandez-Tejero, María, Vehreschild, Maria J G T, Manunta, Maria, Acosta-Herrera, Marialbert, D'Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Grimsrud, Marit M, Cornberg, Markus, Nöthen, Markus M, Marquié, Marta, Castoldi, Massimo, Cordioli, Mattia, Cecconi, Maurizio, D'Amato, Mauro, Augustin, Max, Tomasi, Melissa, Boada, Mercè, Dreher, Michael, Seilmaier, Michael J, Joannidis, Michael, Wittig, Michael, Mazzocco, Michela, Ciccarelli, Michele, Rodríguez-Gandía, Miguel, Bocciolone, Monica, Miozzo, Monica, Ayo, Natale Imaz, Blay, Natalia, Chueca, Natalia, Montano, Nicola, Braun, Nicole, Ludwig, Nicole, Marx, Nikolaus, Martínez, Nilda, Cornely, Oliver A, Witzke, Oliver, Palmieri, Orazio, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Tentorio, Paolo, Castro, Pedro, Rodrigues, Pedro M, España, Pedro Pablo, Hoffmann, Per, Rosenstiel, Philip, Schommers, Philipp, Suwalski, Phillip, Pablo, Raúl, Ferrer, Ricard, Bals, Robert, Gualtierotti, Roberta, Gallego-Durán, Rocío, Nieto, Rosa, Carpani, Rossana, Morilla, Rubén, Badalamenti, Salvatore, Haider, Sammra, Ciesek, Sandra, May, Sandra, Bombace, Sara, Marsal, Sara, Pigazzini, Sara, Klein, Sebastian, Pelusi, Serena, Wilfling, Sibylle, Bosari, Silvano, Volland, Sonja, Brunak, Søren, Raychaudhuri, Soumya, Schreiber, Stefan, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Ripke, Stephan, Dudman, Susanne, Wesse, Tanja, Zheng, Tenghao, Bahmer, Thomas, Eggermann, Thomas, Illig, Thomas, Brenner, Thorsten, Pumarola, Tomas, Feldt, Torsten, Folseraas, Trine, Cejudo, Trinidad Gonzalez, Landmesser, Ulf, Protzer, Ulrike, Hehr, Ute, Rimoldi, Valeria, Monzani, Valter, Skogen, Vegard, Keitel, Verena, Kopfnagel, Verena, Friaza, Vicente, Andrade, Victor, Moreno, Victor, Albrecht, Wolfgang, Peter, Wolfgang, Poller, Wolfgang, Farre, Xavier, Yi, Xiaoli, Wang, Xiaomin, Khodamoradi, Yascha, Karadeniz, Zehra, Latiano, Anna, Goerg, Siegfried, Bacher, Petra, Koehler, Philipp, Tran, Florian, Zoller, Heinz, Schulte, Eva C, Heidecker, Bettina, Ludwig, Kerstin U, Fernández, Javier, Romero-Gómez, Manuel, Albillos, Agustín, Invernizzi, Pietro, Buti, Maria, Duga, Stefano, Bujanda, Luis, Hov, Johannes R, Lenz, Tobias L, Asselta, Rosanna, Cid, Rafael, Valenti, Luca, Karlsen, Tom H, Cáceres, Mario, Franke, Andre, Degenhardt, F, Ellinghaus, D, Juzenas, S, Lerga-Jaso, J, Wendorff, M, Maya-Miles, D, Uellendahl-Werth, F, Elabd, H, Rühlemann, M, Arora, J, Özer, O, Lenning, O, Myhre, R, Vadla, M, Wacker, E, Wienbrandt, L, Ortiz, A, Salazar, A, Chercoles, A, Palom, A, Ruiz, A, Garcia-Fernandez, A, Blanco-Grau, A, Mantovani, A, Zanella, A, Holten, A, Mayer, A, Bandera, A, Cherubini, A, Protti, A, Aghemo, A, Gerussi, A, Ramirez, A, Braun, A, Nebel, A, Barreira, A, Lleo, A, Teles, A, Kildal, A, Biondi, A, Caballero-Garralda, A, Ganna, A, Gori, A, Glück, A, Lind, A, Tanck, A, Hinney, A, Nolla, A, Fracanzani, A, Peschuck, A, Cavallero, A, Dyrhol-Riise, A, Ruello, A, Julià, A, Muscatello, A, Pesenti, A, Voza, A, Rando-Segura, A, Solier, A, Schmidt, A, Cortes, B, Mateos, B, Nafria-Jimenez, B, Schaefer, B, Jensen, B, Bellinghausen, C, Maj, C, Ferrando, C, Horra, C, Quereda, C, Skurk, C, Thibeault, C, Scollo, C, Herr, C, Spinner, C, Gassner, C, Lange, C, Hu, C, Paccapelo, C, Lehmann, C, Angelini, C, Cappadona, C, Azuure, C, Bianco, C, Cea, C, Sancho, C, Hoff, D, Galimberti, D, Prati, D, Haschka, D, Jiménez, D, Pestaña, D, Toapanta, D, Muñiz-Diaz, E, Azzolini, E, Sandoval, E, Binatti, E, Scarpini, E, Helbig, E, Casalone, E, Urrechaga, E, Paraboschi, E, Pontali, E, Reverter, E, Calderón, E, Navas, E, Solligård, E, Contro, E, Arana-Arri, E, Aziz, F, Garcia, F, Sánchez, F, Ceriotti, F, Martinelli-Boneschi, F, Peyvandi, F, Kurth, F, Blasi, F, Malvestiti, F, Medrano, F, Mesonero, F, Rodriguez-Frias, F, Hanses, F, Müller, F, Hemmrich-Stanisak, G, Bellani, G, Grasselli, G, Pezzoli, G, Costantino, G, Albano, G, Cardamone, G, Bellelli, G, Citerio, G, Foti, G, Lamorte, G, Matullo, G, Baselli, G, Kurihara, H, Neb, H, My, I, Kurth, I, Hernández, I, Pink, I, Rojas, I, Galván-Femenia, I, Holter, J, Afset, J, Heyckendorf, J, Kässens, J, Damås, J, Rybniker, J, Altmüller, J, Ampuero, J, Martín, J, Erdmann, J, Banales, J, Badia, J, Dopazo, J, Schneider, J, Bergan, J, Barretina, J, Walter, J, Quero, J, Goikoetxea, J, Delgado, J, Guerrero, J, Fazaal, J, Kraft, J, Schröder, J, Risnes, K, Banasik, K, Müller, K, Gaede, K, Garcia-Etxebarria, K, Tonby, K, Heggelund, L, Izquierdo-Sanchez, L, Bettini, L, Sumoy, L, Sander, L, Lippert, L, Terranova, L, Nkambule, L, Knopp, L, Gustad, L, Garbarino, L, Santoro, L, Téllez, L, Roade, L, Ostadreza, M, Intxausti, M, Kogevinas, M, Riveiro-Barciela, M, Berger, M, Schaefer, M, Niemi, M, Gutiérrez-Stampa, M, Carrabba, M, Figuera Basso, M, Valsecchi, M, Hernandez-Tejero, M, Vehreschild, M, Manunta, M, Acosta-Herrera, M, D'Angiò, M, Baldini, M, Cazzaniga, M, Grimsrud, M, Cornberg, M, Nöthen, M, Marquié, M, Castoldi, M, Cordioli, M, Cecconi, M, D'Amato, M, Augustin, M, Tomasi, M, Boada, M, Dreher, M, Seilmaier, M, Joannidis, M, Wittig, M, Mazzocco, M, Ciccarelli, M, Rodríguez-Gandía, M, Bocciolone, M, Miozzo, M, Ayo, N, Blay, N, Chueca, N, Montano, N, Braun, N, Ludwig, N, Marx, N, Martínez, N, Cornely, O, Witzke, O, Palmieri, O, Faverio, P, Preatoni, P, Bonfanti, P, Omodei, P, Tentorio, P, Castro, P, Rodrigues, P, España, P, Hoffmann, P, Rosenstiel, P, Schommers, P, Suwalski, P, Pablo, R, Ferrer, R, Bals, R, Gualtierotti, R, Gallego-Durán, R, Nieto, R, Carpani, R, Morilla, R, Badalamenti, S, Haider, S, Ciesek, S, May, S, Bombace, S, Marsal, S, Pigazzini, S, Klein, S, Pelusi, S, Wilfling, S, Bosari, S, Volland, S, Brunak, S, Raychaudhuri, S, Schreiber, S, Heilmann-Heimbach, S, Aliberti, S, Ripke, S, Dudman, S, Wesse, T, Zheng, T, Bahmer, T, Eggermann, T, Illig, T, Brenner, T, Pumarola, T, Feldt, T, Folseraas, T, Cejudo, T, Landmesser, U, Protzer, U, Hehr, U, Rimoldi, V, Monzani, V, Skogen, V, Keitel, V, Kopfnagel, V, Friaza, V, Andrade, V, Moreno, V, Albrecht, W, Peter, W, Poller, W, Farre, X, Yi, X, Wang, X, Khodamoradi, Y, Karadeniz, Z, Latiano, A, Goerg, S, Bacher, P, Koehler, P, Tran, F, Zoller, H, Schulte, E, Heidecker, B, Ludwig, K, Fernández, J, Romero-Gómez, M, Albillos, A, Invernizzi, P, Buti, M, Duga, S, Bujanda, L, Hov, J, Lenz, T, Asselta, R, Cid, R, Valenti, L, Karlsen, T, Cáceres, M, Franke, A, Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga-Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, Rühlemann, Malte C, Arora, Jatin, Özer, Onur, Lenning, Ole Bernt, Myhre, Ronny, Vadla, May Sissel, Wacker, Eike M, Wienbrandt, Lars, Ortiz, Aaron Blandino, Salazar, Adolfo, Chercoles, Adolfo Garrido, Palom, Adriana, Ruiz, Agustín, Garcia-Fernandez, Alba-Estela, Blanco-Grau, Albert, Mantovani, Alberto, Zanella, Alberto, Holten, Aleksander Rygh, Mayer, Alena, Bandera, Alessandra, Cherubini, Alessandro, Protti, Alessandro, Aghemo, Alessio, Gerussi, Alessio, Ramirez, Alfredo, Braun, Alice, Nebel, Almut, Barreira, Ana, Lleo, Ana, Teles, Ana, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Ganna, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Tanck, Anja, Hinney, Anke, Nolla, Anna Carreras, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, Julià, Antonio, Muscatello, Antonio, Pesenti, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier, Aurora, Schmidt, Axel, Cortes, Beatriz, Mateos, Beatriz, Nafria-Jimenez, Beatriz, Schaefer, Benedikt, Jensen, Björn, Bellinghausen, Carla, Maj, Carlo, Ferrando, Carlos, Horra, Carmen, Quereda, Carmen, Skurk, Carsten, Thibeault, Charlotte, Scollo, Chiara, Herr, Christian, Spinner, Christoph D, Gassner, Christoph, Lange, Christoph, Hu, Cinzia, Paccapelo, Cinzia, Lehmann, Clara, Angelini, Claudio, Cappadona, Claudio, Azuure, Clinton, Bianco, Cristiana, Cea, Cristina, Sancho, Cristina, Hoff, Dag Arne Lihaug, Galimberti, Daniela, Prati, Daniele, Haschka, David, Jiménez, David, Pestaña, David, Toapanta, David, Muñiz-Diaz, Eduardo, Azzolini, Elena, Sandoval, Elena, Binatti, Eleonora, Scarpini, Elio, Helbig, Elisa T, Casalone, Elisabetta, Urrechaga, Eloisa, Paraboschi, Elvezia Maria, Pontali, Emanuele, Reverter, Enric, Calderón, Enrique J, Navas, Enrique, Solligård, Erik, Contro, Ernesto, Arana-Arri, Eunate, Aziz, Fátima, Garcia, Federico, Sánchez, Félix García, Ceriotti, Ferruccio, Martinelli-Boneschi, Filippo, Peyvandi, Flora, Kurth, Florian, Blasi, Francesco, Malvestiti, Francesco, Medrano, Francisco J, Mesonero, Francisco, Rodriguez-Frias, Francisco, Hanses, Frank, Müller, Fredrik, Hemmrich-Stanisak, Georg, Bellani, Giacomo, Grasselli, Giacomo, Pezzoli, Gianni, Costantino, Giorgio, Albano, Giovanni, Cardamone, Giulia, Bellelli, Giuseppe, Citerio, Giuseppe, Foti, Giuseppe, Lamorte, Giuseppe, Matullo, Giuseppe, Baselli, Guido, Kurihara, Hayato, Neb, Holger, My, Ilaria, Kurth, Ingo, Hernández, Isabel, Pink, Isabell, Rojas, Itziar, Galván-Femenia, Iván, Holter, Jan Cato, Afset, Jan Egil, Heyckendorf, Jan, Kässens, Jan, Damås, Jan Kristian, Rybniker, Jan, Altmüller, Janine, Ampuero, Javier, Martín, Javier, Erdmann, Jeanette, Banales, Jesus M, Badia, Joan Ramon, Dopazo, Joaquin, Schneider, Jochen, Bergan, Jonas, Barretina, Jordi, Walter, Jörn, Quero, Jose Hernández, Goikoetxea, Josune, Delgado, Juan, Guerrero, Juan M, Fazaal, Julia, Kraft, Julia, Schröder, Julia, Risnes, Kari, Banasik, Karina, Müller, Karl Erik, Gaede, Karoline I, Garcia-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lars, Izquierdo-Sanchez, Laura, Bettini, Laura Rachele, Sumoy, Lauro, Sander, Leif Erik, Lippert, Lena J, Terranova, Leonardo, Nkambule, Lindokuhle, Knopp, Lisa, Gustad, Lise Tuset, Garbarino, Lucia, Santoro, Luigi, Téllez, Luis, Roade, Luisa, Ostadreza, Mahnoosh, Intxausti, Maider, Kogevinas, Manolis, Riveiro-Barciela, Mar, Berger, Marc M, Schaefer, Marco, Niemi, Mari E K, Gutiérrez-Stampa, María A, Carrabba, Maria, Figuera Basso, Maria E, Valsecchi, Maria Grazia, Hernandez-Tejero, María, Vehreschild, Maria J G T, Manunta, Maria, Acosta-Herrera, Marialbert, D'Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Grimsrud, Marit M, Cornberg, Markus, Nöthen, Markus M, Marquié, Marta, Castoldi, Massimo, Cordioli, Mattia, Cecconi, Maurizio, D'Amato, Mauro, Augustin, Max, Tomasi, Melissa, Boada, Mercè, Dreher, Michael, Seilmaier, Michael J, Joannidis, Michael, Wittig, Michael, Mazzocco, Michela, Ciccarelli, Michele, Rodríguez-Gandía, Miguel, Bocciolone, Monica, Miozzo, Monica, Ayo, Natale Imaz, Blay, Natalia, Chueca, Natalia, Montano, Nicola, Braun, Nicole, Ludwig, Nicole, Marx, Nikolaus, Martínez, Nilda, Cornely, Oliver A, Witzke, Oliver, Palmieri, Orazio, Faverio, Paola, Preatoni, Paoletta, Bonfanti, Paolo, Omodei, Paolo, Tentorio, Paolo, Castro, Pedro, Rodrigues, Pedro M, España, Pedro Pablo, Hoffmann, Per, Rosenstiel, Philip, Schommers, Philipp, Suwalski, Phillip, Pablo, Raúl, Ferrer, Ricard, Bals, Robert, Gualtierotti, Roberta, Gallego-Durán, Rocío, Nieto, Rosa, Carpani, Rossana, Morilla, Rubén, Badalamenti, Salvatore, Haider, Sammra, Ciesek, Sandra, May, Sandra, Bombace, Sara, Marsal, Sara, Pigazzini, Sara, Klein, Sebastian, Pelusi, Serena, Wilfling, Sibylle, Bosari, Silvano, Volland, Sonja, Brunak, Søren, Raychaudhuri, Soumya, Schreiber, Stefan, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Ripke, Stephan, Dudman, Susanne, Wesse, Tanja, Zheng, Tenghao, Bahmer, Thomas, Eggermann, Thomas, Illig, Thomas, Brenner, Thorsten, Pumarola, Tomas, Feldt, Torsten, Folseraas, Trine, Cejudo, Trinidad Gonzalez, Landmesser, Ulf, Protzer, Ulrike, Hehr, Ute, Rimoldi, Valeria, Monzani, Valter, Skogen, Vegard, Keitel, Verena, Kopfnagel, Verena, Friaza, Vicente, Andrade, Victor, Moreno, Victor, Albrecht, Wolfgang, Peter, Wolfgang, Poller, Wolfgang, Farre, Xavier, Yi, Xiaoli, Wang, Xiaomin, Khodamoradi, Yascha, Karadeniz, Zehra, Latiano, Anna, Goerg, Siegfried, Bacher, Petra, Koehler, Philipp, Tran, Florian, Zoller, Heinz, Schulte, Eva C, Heidecker, Bettina, Ludwig, Kerstin U, Fernández, Javier, Romero-Gómez, Manuel, Albillos, Agustín, Invernizzi, Pietro, Buti, Maria, Duga, Stefano, Bujanda, Luis, Hov, Johannes R, Lenz, Tobias L, Asselta, Rosanna, Cid, Rafael, Valenti, Luca, Karlsen, Tom H, Cáceres, Mario, and Franke, Andre
- Abstract
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ∼0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
- Published
- 2022
42. Detailed stratified GWAS analysis for severe COVID-19 in four European populations
- Author
-
Federal Ministry of Education and Research (Germany), German Research Foundation, Novo Nordisk Foundation, Ministero della Salute, European Commission, Fondazione Cariplo, Ministero dell'Istruzione, dell'Università e della Ricerca, Generalitat de Catalunya, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Fundación la Caixa, Eusko Jaurlaritza, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (España), Norwegian Research Council, German Center for Lung Research, Airway Research Center North (Germany), Miltenyi Biotec, University of Cologne, Technical University of Munich, Finnish Institute for Molecular Medicine, University of Helsinki, Saarland University, University Hospital Bonn, Bavarian State Ministry of Education, Science and the Arts, Essen University Hospital, Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga-Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, Rühlemann, Malte C., Arora, Jatin, Özer, Onur, Salazar, Adolfo de, Risnes, Kari, Banasik, Karina, Müller, Karl Erik, Gaede, Karoline I., Pigazzini, Sara, García-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lars, Asselta, Rosanna, Sancho, Cristina, Ruiz, Agustín, Izquierdo-Sanchez, Laura, Rachele Bettini, Laura, Sumoy, Lauro, Garrido Chercoles, Adolfo, Sander, Leif Erik, Valsecchi, Maria Grazia, Klein, Sebastian, Hernández-Tejero, María, Vehreschild, Maria J. G. T., Lihaug Hoff, Dag Arne, Roade, Luisa, Manunta, Maria, Acosta-Herrera, Marialbert, D’Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Grimsrud, Marit M., Urrechaga, Eloisa, Cornberg, Markus, Pelusi, Serena, Galimberti, Daniela, García-Fernández, Alba-Estela, Bals, Robert, Nöthen, Markus M., Marquié, Marta, Castoldi, Massimo, Cordioli, Mattia, Cecconi, Maurizio, D’Amato, Mauro, Augustin, Max, Tomasi, Melissa, Prati, Daniele, Paraboschi, Elvezia Maria, Bandera, Alessandra, Braun, Alice, Boada, Mercè, Dreher, Michael, Blanco-Grau, Albert, Seilmaier, Michael J., Joannidis, Michael, Wittig, Michael, Mazzocco, Michela, Haschka, David, Ciccarelli, Michele, Rodríguez-Gandía, Miguel, Bocciolone, Monica, Cid, Rafael de, Wilfling, Sibylle, Pontali, Emanuele, Miozzo, Monica, Imaz Ayo, Natale, Blay, Natalia, Mantovani, Alberto, Berger, Marc M., Chueca, Natalia, Montano, Nicola, Braun, Nicole, Ludwig, Nicole, Valenti, Luca, Marx, Nikolaus, Bosari, Silvano, Martínez, Nilda, Reverter, Enric, Norwegian SARS-CoV-2 Study group, Jiménez, David, Cornely, Oliver A., Witzke, Oliver, Palmieri, Orazio, Zanella, Alberto, Pa COVID-19 Study Group, Karlsen, Tom H., Faverio, Paola, Preatoni, Paoletta, Terranova, Leonardo, Bonfanti, Paolo, Pestaña, David, Omodei, Paolo, Calderón, Enrique J., Tentorio, Paolo, Castro Blázquez, Pedro, Rodrigues, Pedro M., España, Pedro Pablo, Cáceres, Mario, Hoffmann, Per, Holten, Aleksander Rygh, Rosenstiel, Philip, Toapanta, David, Contro, Ernesto, Schommers, Philipp, Suwalski, Phillip, Pablo, Raúl de, Navas, Enrique, Ferrer, Ricard, Volland, Sonja, Franke, Andre, Brunak, Søren, Raychaudhuri, Soumya, Haider, Sammra, Schreiber, Stefan, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Ripke, Stephan, Dudman, Susanne, Cherubini, Alessandro, Nkambule, Lindokuhle, Wesse, Tanja, Nebel, Almut, Lenning, Ole Bernt, Albillos, Agustín, Zheng, Tenghao, The Humanitas COVID-19 Task Force, The Humanitas Gavazzeni COVID-19 Task Force, Bahmer, Thomas, Eggermann, Thomas, Illig, Thomas, Brenner, Thorsten, Pumarola, Tomàs, Knopp, Lisa, Martinelli-Boneschi, Filippo, Medrano, Francisco Javier, Feldt, Torsten, Protti, Alessandro, Arana-Arri, Eunate, Folseraas, Trine, Gonzalez Cejudo, Trinidad, Landmesser, Ulf, Protzer, Ulrike, Hehr, Ute, Rimoldi, Valeria, Monzani, Valter, Muñiz-Diaz, Eduardo, Barreira, Ana, Gustad, Lise Tuset, Skogen, Vegard, Keitel, Verena, Kopfnagel, Verena, Aziz, Fátima, Aghemo, Alessio, Friaza Patiño, Vicente, Andrade, Victor, Moreno, Victor, Azzolini, Elena, Albrecht, Wolfgang, Lleo, Ana, Peter, Wolfgang, Garbarino, Lucia, Poller, Wolfgang, Farré, Xavier, Yi, Xiaoli, Wang, Xiaomin, García, Federico, Khodamoradi, Yascha, Sandoval, Elena, Gerussi, Alessio, Karadeniz, Zehra, Gualtierotti, Roberta, Latiano, Anna, Goerg, Siegfried, Santoro, Luigi, Bacher, Petra, Koehler, Philipp, Tran, Florian, Zoller, Heinz, Binatti, Eleonora, Schulte, Eva C., García Sánchez, Félix, Heidecker, Bettina, Palom, Adriana, Ludwig, Kerstin U., Ramírez, Alfredo, Fernández, Javier, Téllez, Luis, Romero-Gómez, Manuel, Teles, Ana, Scarpini, Elio, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Ganna, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Peyvandi, Flora, Gallego-Durán, Rocío, Tanck, Anja, Mesonero, Francisco, Helbig, Elisa T., Hinney, Anke, Carreras Nolla, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, Julià, Antonio, Nieto, Rosa, Schaefer, Marco, Muscatello, Antonio, Kurth, Florian, Ostadreza, Mahnoosh, Pesenti, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier-López, Aurora, Schmidt, Axel, Cortes, Beatriz, Mateos, Beatriz, Rodríguez-Frías, Francisco, Carpani, Rossana, Nafría-Jiménez, Beatriz, Schaefer, Benedikt, Jensen, Björn, Intxausti, Maider, Blasi, Francesco, Bellinghausen, Carla, Maj, Carlo, Ferrando, Carlos, Horra, Carmen de la, Hanses, Frank, Quereda, Carmen, Mayer, Alena, Skurk, Carsten, Thibeault, Charlotte, Scollo, Chiara, Herr, Christian, Kogevinas, Manolis, Spinner, Christoph D., Malvestiti, Francesco, Gassner, Christoph, Invernizzi, Pietro, Lange, Christoph, Hu, Cinzia, Morilla Romero de la Osa, R., Paccapelo, Cinzia, Lehmann, Clara, Angelini, Claudio, Cappadona, Claudio, Azuure, Clinton, Riveiro-Barciela, Mar, COVICAT study group, Solligård, Erik, Covid-19 Aachen Study (COVAS), Myhre, Ronny, Bianco, Cristiana, Badalamenti, Salvatore, Cea, Cristina, Müller, Fredrik, Hemmrich-Stanisak, Georg, Bellani, Giacomo, Grasselli, Giacomo, Pezzoli, Gianni, Costantino, Giorgio, Vadla, May Sissel, Albano, Giovanni, Niemi, Mari, Buti, María, Cardamone, Giulia, Lippert, Lena J., Bellelli, Giuseppe, Citerio, Giuseppe, Foti, Giuseppe, Lamorte, Giuseppe, Matullo, Giuseppe, Baselli, Guido, Kurihara, Hayato, Neb, Holger, Duga, Stefano, Wacker, Eike M., Gutiérrez-Stampa, María A., Ciesek, Sandra, My, Ilaria, Kurth, Ingo, Hernández, Isabel, Pink, Isabell, Rojas, Itziar de, Galván-Femenia, Iván, Holter, Jan Cato, Bujanda, Luis, Afset, Jan Egil, Heyckendorf, Jan, Kässens, Jan, May, Sandra, Carrabba, Maria, Wienbrandt, Lars, Damås, Jan Kristian, Rybniker, Jan, Altmüller, Janine, Ampuero, Javier, Ceriotti, Ferruccio, Martín, Javier, Erdmann, Jeanette, Banales, Jesús M., Badia, Joan Ramon, Bombace, Sara, Dopazo, Joaquín, Figuera Basso, Maria E., Schneider, Jochen, Blandino Ortiz, Aaron, Bergan, Jonas, Hov, Johannes R., Barretina, Jordi, Walter, Jörn, Hernández Quero, José, Goikoetxea-Aguirre, Josune, Delgado, Juan, Marsal, Sara, Guerrero, Juan M., Fazaal, Julia, Casalone, Elisabetta, Kraft, Julia, Lenz, Tobias L., Schröder, Julia, Federal Ministry of Education and Research (Germany), German Research Foundation, Novo Nordisk Foundation, Ministero della Salute, European Commission, Fondazione Cariplo, Ministero dell'Istruzione, dell'Università e della Ricerca, Generalitat de Catalunya, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Fundación la Caixa, Eusko Jaurlaritza, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Junta de Andalucía, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (España), Norwegian Research Council, German Center for Lung Research, Airway Research Center North (Germany), Miltenyi Biotec, University of Cologne, Technical University of Munich, Finnish Institute for Molecular Medicine, University of Helsinki, Saarland University, University Hospital Bonn, Bavarian State Ministry of Education, Science and the Arts, Essen University Hospital, Degenhardt, Frauke, Ellinghaus, David, Juzenas, Simonas, Lerga-Jaso, Jon, Wendorff, Mareike, Maya-Miles, Douglas, Uellendahl-Werth, Florian, ElAbd, Hesham, Rühlemann, Malte C., Arora, Jatin, Özer, Onur, Salazar, Adolfo de, Risnes, Kari, Banasik, Karina, Müller, Karl Erik, Gaede, Karoline I., Pigazzini, Sara, García-Etxebarria, Koldo, Tonby, Kristian, Heggelund, Lars, Asselta, Rosanna, Sancho, Cristina, Ruiz, Agustín, Izquierdo-Sanchez, Laura, Rachele Bettini, Laura, Sumoy, Lauro, Garrido Chercoles, Adolfo, Sander, Leif Erik, Valsecchi, Maria Grazia, Klein, Sebastian, Hernández-Tejero, María, Vehreschild, Maria J. G. T., Lihaug Hoff, Dag Arne, Roade, Luisa, Manunta, Maria, Acosta-Herrera, Marialbert, D’Angiò, Mariella, Baldini, Marina, Cazzaniga, Marina, Grimsrud, Marit M., Urrechaga, Eloisa, Cornberg, Markus, Pelusi, Serena, Galimberti, Daniela, García-Fernández, Alba-Estela, Bals, Robert, Nöthen, Markus M., Marquié, Marta, Castoldi, Massimo, Cordioli, Mattia, Cecconi, Maurizio, D’Amato, Mauro, Augustin, Max, Tomasi, Melissa, Prati, Daniele, Paraboschi, Elvezia Maria, Bandera, Alessandra, Braun, Alice, Boada, Mercè, Dreher, Michael, Blanco-Grau, Albert, Seilmaier, Michael J., Joannidis, Michael, Wittig, Michael, Mazzocco, Michela, Haschka, David, Ciccarelli, Michele, Rodríguez-Gandía, Miguel, Bocciolone, Monica, Cid, Rafael de, Wilfling, Sibylle, Pontali, Emanuele, Miozzo, Monica, Imaz Ayo, Natale, Blay, Natalia, Mantovani, Alberto, Berger, Marc M., Chueca, Natalia, Montano, Nicola, Braun, Nicole, Ludwig, Nicole, Valenti, Luca, Marx, Nikolaus, Bosari, Silvano, Martínez, Nilda, Reverter, Enric, Norwegian SARS-CoV-2 Study group, Jiménez, David, Cornely, Oliver A., Witzke, Oliver, Palmieri, Orazio, Zanella, Alberto, Pa COVID-19 Study Group, Karlsen, Tom H., Faverio, Paola, Preatoni, Paoletta, Terranova, Leonardo, Bonfanti, Paolo, Pestaña, David, Omodei, Paolo, Calderón, Enrique J., Tentorio, Paolo, Castro Blázquez, Pedro, Rodrigues, Pedro M., España, Pedro Pablo, Cáceres, Mario, Hoffmann, Per, Holten, Aleksander Rygh, Rosenstiel, Philip, Toapanta, David, Contro, Ernesto, Schommers, Philipp, Suwalski, Phillip, Pablo, Raúl de, Navas, Enrique, Ferrer, Ricard, Volland, Sonja, Franke, Andre, Brunak, Søren, Raychaudhuri, Soumya, Haider, Sammra, Schreiber, Stefan, Heilmann-Heimbach, Stefanie, Aliberti, Stefano, Ripke, Stephan, Dudman, Susanne, Cherubini, Alessandro, Nkambule, Lindokuhle, Wesse, Tanja, Nebel, Almut, Lenning, Ole Bernt, Albillos, Agustín, Zheng, Tenghao, The Humanitas COVID-19 Task Force, The Humanitas Gavazzeni COVID-19 Task Force, Bahmer, Thomas, Eggermann, Thomas, Illig, Thomas, Brenner, Thorsten, Pumarola, Tomàs, Knopp, Lisa, Martinelli-Boneschi, Filippo, Medrano, Francisco Javier, Feldt, Torsten, Protti, Alessandro, Arana-Arri, Eunate, Folseraas, Trine, Gonzalez Cejudo, Trinidad, Landmesser, Ulf, Protzer, Ulrike, Hehr, Ute, Rimoldi, Valeria, Monzani, Valter, Muñiz-Diaz, Eduardo, Barreira, Ana, Gustad, Lise Tuset, Skogen, Vegard, Keitel, Verena, Kopfnagel, Verena, Aziz, Fátima, Aghemo, Alessio, Friaza Patiño, Vicente, Andrade, Victor, Moreno, Victor, Azzolini, Elena, Albrecht, Wolfgang, Lleo, Ana, Peter, Wolfgang, Garbarino, Lucia, Poller, Wolfgang, Farré, Xavier, Yi, Xiaoli, Wang, Xiaomin, García, Federico, Khodamoradi, Yascha, Sandoval, Elena, Gerussi, Alessio, Karadeniz, Zehra, Gualtierotti, Roberta, Latiano, Anna, Goerg, Siegfried, Santoro, Luigi, Bacher, Petra, Koehler, Philipp, Tran, Florian, Zoller, Heinz, Binatti, Eleonora, Schulte, Eva C., García Sánchez, Félix, Heidecker, Bettina, Palom, Adriana, Ludwig, Kerstin U., Ramírez, Alfredo, Fernández, Javier, Téllez, Luis, Romero-Gómez, Manuel, Teles, Ana, Scarpini, Elio, Kildal, Anders Benjamin, Biondi, Andrea, Caballero-Garralda, Andrea, Ganna, Andrea, Gori, Andrea, Glück, Andreas, Lind, Andreas, Peyvandi, Flora, Gallego-Durán, Rocío, Tanck, Anja, Mesonero, Francisco, Helbig, Elisa T., Hinney, Anke, Carreras Nolla, Anna, Fracanzani, Anna Ludovica, Peschuck, Anna, Cavallero, Annalisa, Dyrhol-Riise, Anne Ma, Ruello, Antonella, Julià, Antonio, Nieto, Rosa, Schaefer, Marco, Muscatello, Antonio, Kurth, Florian, Ostadreza, Mahnoosh, Pesenti, Antonio, Voza, Antonio, Rando-Segura, Ariadna, Solier-López, Aurora, Schmidt, Axel, Cortes, Beatriz, Mateos, Beatriz, Rodríguez-Frías, Francisco, Carpani, Rossana, Nafría-Jiménez, Beatriz, Schaefer, Benedikt, Jensen, Björn, Intxausti, Maider, Blasi, Francesco, Bellinghausen, Carla, Maj, Carlo, Ferrando, Carlos, Horra, Carmen de la, Hanses, Frank, Quereda, Carmen, Mayer, Alena, Skurk, Carsten, Thibeault, Charlotte, Scollo, Chiara, Herr, Christian, Kogevinas, Manolis, Spinner, Christoph D., Malvestiti, Francesco, Gassner, Christoph, Invernizzi, Pietro, Lange, Christoph, Hu, Cinzia, Morilla Romero de la Osa, R., Paccapelo, Cinzia, Lehmann, Clara, Angelini, Claudio, Cappadona, Claudio, Azuure, Clinton, Riveiro-Barciela, Mar, COVICAT study group, Solligård, Erik, Covid-19 Aachen Study (COVAS), Myhre, Ronny, Bianco, Cristiana, Badalamenti, Salvatore, Cea, Cristina, Müller, Fredrik, Hemmrich-Stanisak, Georg, Bellani, Giacomo, Grasselli, Giacomo, Pezzoli, Gianni, Costantino, Giorgio, Vadla, May Sissel, Albano, Giovanni, Niemi, Mari, Buti, María, Cardamone, Giulia, Lippert, Lena J., Bellelli, Giuseppe, Citerio, Giuseppe, Foti, Giuseppe, Lamorte, Giuseppe, Matullo, Giuseppe, Baselli, Guido, Kurihara, Hayato, Neb, Holger, Duga, Stefano, Wacker, Eike M., Gutiérrez-Stampa, María A., Ciesek, Sandra, My, Ilaria, Kurth, Ingo, Hernández, Isabel, Pink, Isabell, Rojas, Itziar de, Galván-Femenia, Iván, Holter, Jan Cato, Bujanda, Luis, Afset, Jan Egil, Heyckendorf, Jan, Kässens, Jan, May, Sandra, Carrabba, Maria, Wienbrandt, Lars, Damås, Jan Kristian, Rybniker, Jan, Altmüller, Janine, Ampuero, Javier, Ceriotti, Ferruccio, Martín, Javier, Erdmann, Jeanette, Banales, Jesús M., Badia, Joan Ramon, Bombace, Sara, Dopazo, Joaquín, Figuera Basso, Maria E., Schneider, Jochen, Blandino Ortiz, Aaron, Bergan, Jonas, Hov, Johannes R., Barretina, Jordi, Walter, Jörn, Hernández Quero, José, Goikoetxea-Aguirre, Josune, Delgado, Juan, Marsal, Sara, Guerrero, Juan M., Fazaal, Julia, Casalone, Elisabetta, Kraft, Julia, Lenz, Tobias L., and Schröder, Julia
- Abstract
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended genome-wide association meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.
- Published
- 2022
43. Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
- Author
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Junta de Andalucía, Instituto de Salud Carlos III, European Association for the Study of the Liver, Asociación Española para el Estudio del Hígado, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Gallego-Durán, Rocío, Ampuero, Javier, Pastor-Ramírez, Helena, Álvarez-Amor, Leticia, Campo, José A. del, Maya-Miles, Douglas, Montero-Vallejo, Rocío, Cárdenas-García, Antonio, Pareja, María Jesús, Gato, Sheila, Millán Domínguez, Raquel, Rico, María Carmen, Luque-Sierra, Amparo, Gil-Gómez, Antonio, Rojas, Ángela, Muñoz-Hernández, Rocío, García-Lozano, María del Rosario, Aller, Rocío, Andrade, Raúl J., García-Monzón, Carmelo, Andreola, Fausto, Martín, Franz, Jalan, Rajiv, Romero-Gómez, Manuel, Junta de Andalucía, Instituto de Salud Carlos III, European Association for the Study of the Liver, Asociación Española para el Estudio del Hígado, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), Gallego-Durán, Rocío, Ampuero, Javier, Pastor-Ramírez, Helena, Álvarez-Amor, Leticia, Campo, José A. del, Maya-Miles, Douglas, Montero-Vallejo, Rocío, Cárdenas-García, Antonio, Pareja, María Jesús, Gato, Sheila, Millán Domínguez, Raquel, Rico, María Carmen, Luque-Sierra, Amparo, Gil-Gómez, Antonio, Rojas, Ángela, Muñoz-Hernández, Rocío, García-Lozano, María del Rosario, Aller, Rocío, Andrade, Raúl J., García-Monzón, Carmelo, Andreola, Fausto, Martín, Franz, Jalan, Rajiv, and Romero-Gómez, Manuel
- Abstract
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD patients were genotyped for rs1047891, a functional variant located in carbamoyl phosphate synthetase-1 (CPS1) gene. Two preclinical models were employed to analyse CPS1 by immunohistochemistry, a choline deficient high-fat diet model (CDA-HFD) and a high fat diet LDLr knockout model (LDLr −/−). A significant downregulation in mRNA was observed in CPS1 and ornithine transcarbamylase (OTC1) in simple steatosis and NASH-fibrosis patients versus controls. Further, age, obesity (BMI > 30 kg/m), diabetes mellitus and ALT werefound to be risk factors whereas A-allele from CPS1 was a protective factor from liver fibrosis. CPS1 hepatic expression was diminished in parallel with the increase of fibrosis, and its levels reverted up to normality after changing diet in CDA-HFD mice. In conclusion, liver fibrosis and steatosis were associated with a reduction in both gene and protein expression patterns of mitochondrial urea cycle enzymes. A-allele from a variant on CPS1 may protect from fibrosis development. CPS1 expression is restored in a preclinical model when the main trigger of the liver damage disappears.
- Published
- 2022
44. L
- Author
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Seewald, J. S., Eglinton, T. I., McLennan, Scott M., Miles, Douglas L., Palmer, Cynthia E. A., Mihaljevic, Martin, Long, Leon E., Rohmer, Michel, Chen, Ju-chin, Calas, G., Patchett, P. Jonathan, Marshall, Clare P., editor, and Fairbridge, Rhodes W., editor
- Published
- 1999
- Full Text
- View/download PDF
45. Flexible Data Distribution in PGHPF
- Author
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Leair, Mark, Miles, Douglas, Schuster, Vincent, Wolfe, Michael, Amestoy, Patrick, editor, Berger, Philippe, editor, Daydé, Michel, editor, Ruiz, Daniel, editor, Duff, Iain, editor, Frayssé, Valérie, editor, and Giraud, Luc, editor
- Published
- 1999
- Full Text
- View/download PDF
46. Long non‐coding RNA H19 as a biomarker for hepatocellular carcinoma
- Author
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Rojas, Ángela, primary, Gil‐Gómez, Antonio, additional, de la Cruz‐Ojeda, Patricia, additional, Muñoz‐Hernández, Rocío, additional, Sánchez‐Torrijos, Yolanda, additional, Gallego‐Durán, Rocío, additional, Millán, Raquel, additional, Rico, María Carmen, additional, Montero‐Vallejo, Rocío, additional, Gato‐Zambrano, Sheila, additional, Maya‐Miles, Douglas, additional, Ferrer, M. Teresa, additional, Muntané, Jordi, additional, Robles‐Frías, María José, additional, Ampuero, Javier, additional, Padillo, Francisco J., additional, and Romero‐Gómez, Manuel, additional
- Published
- 2022
- Full Text
- View/download PDF
47. Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
- Author
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Gallego Durán, Rocío, Ampuero Herrojo, Javier, Pastor Ramírez, Helena, Álvarez Amor, Leticia, Campo, José Antonio del, Maya Miles, Douglas, Muñoz Hernández, Rocío, Romero Gómez, Manuel, and Universidad de Sevilla. Departamento de Medicina
- Subjects
Urea cycle enzymes ,Liver Injury in non-alcoholic fatty ,Non-alcoholic steatohepatitis (NASH) ,Liver disease ,Cycle enzyme dysregulation - Abstract
The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression analyses. Three-hundred-and-eighty-two biopsy-proven NAFLD patients were genotyped for rs1047891, a functional variant located in carbamoyl phosphate synthetase-1 (CPS1) gene. Two preclinical models were employed to analyse CPS1 by immunohistochemistry, a choline deficient high-fat diet model (CDA-HFD) and a high fat diet LDLr knockout model (LDLr −/−). A significant downregulation in mRNA was observed in CPS1 and ornithine transcarbamylase (OTC1) in simple steatosis and NASH-fibrosis patients versus controls. Further, age, obesity (BMI > 30 kg/m2), diabetes mellitus and ALT were found to be risk factors whereas A-allele from CPS1 was a protective factor from liver fibrosis. CPS1 hepatic expression was diminished in parallel with the increase of fibrosis, and its levels reverted up to normality after changing diet in CDA-HFD mice. In conclusion, liver fibrosis and steatosis were associated with a reduction in both gene and protein expression patterns of mitochondrial urea cycle enzymes. A-allele from a variant on CPS1 may protect from fibrosis development. CPS1 expression is restored in a preclinical model when the main trigger of the liver damage disappears.
- Published
- 2022
48. Systematic review and meta-analysis: analysis of variables influencing the interpretation of clinical trial results in NAFLD
- Author
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Ampuero Herrojo, Javier, Gallego Durán, Rocío, Maya Miles, Douglas, Montero, Rocío, Gato, Sheila, Rojas, Ángela, Gil, Antonio, Muñoz, Rocío, Romero Gómez, Manuel, and Universidad de Sevilla. Departamento de Medicina
- Subjects
NAFLD ,NASH ,Drug ,Fibrosis ,Placebo - Abstract
Background NAFLD clinical trials have shown suboptimal results, particularly for liver fibrosis, despite the robust preclinical drug development. We aimed to assess the histological response after the experimental treatment versus placebo by carrying out a meta-analysis of NAFLD clinical trials. Methods After a systematic review of NAFLD clinical trials to May 2021, applying strict selection criteria, the following primary outcomes were observed: (a) NASH resolution, with no worsening of fibrosis when available; (b) fibrosis improvement ≥ 1 stage, with no worsening of NAS when available; (c) worsening of NAS; (d) worsening of liver fibrosis ≥ 1 stage, including the progression to cirrhosis on histopathology. Other histological, clinical, and biochemical outcomes were considered secondary endpoints. Heterogeneity was explored by subgroup and sensitivity analyses, and univariable meta-regression. Results Twenty-seven randomized clinical trials were included. The pooled efficacy for NASH resolution receiving experimental therapy was 19% (95%CI 15–23; I2 96.2%) compared with placebo 10% (95%CI 7–12; I2 85.8%) (OR 1.66 (95%CI 1.24–2.21); I2 57.8%), while it was 26% (95%CI 22–29); I2 90%)) versus 18% (95%CI 15–21; I2 59%)) for fibrosis improvement (OR 1.34 (95%CI 1.13–1.58); I2 25.4%). For these outcomes, the therapy showed higher efficacy in trials longer than 48 weeks, with
- Published
- 2022
49. A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
- Author
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Guo, Feifei, Maya-Miles, Douglas, Zheng, Kang, Ampuero, Javier, Philip, Kaye, Egbuniwe, Isioma U., Chen, Chaobo, Simon, Jorge, Delgado, Teresa C., Sun, Jie, Reissing, Johanna, Bruns, Tony, Lamas-Paz, Arantza, Woitok, Marius Maximilian, Vaquero, Javier, Liedtke, Christian, Trautwein, Christian, Cubero, Francisco Javier, and Nevzorova, Yulia A.
- Subjects
Cancer Research ,Oncology - Abstract
Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and murine MAFLD and MAFLD-associated HCC. Methods: alb-myctg mice were studied at baseline conditions and after administration of Western diet (WD) in comparison to WT littermates. c-MYC expression was analyzed in biopsies of patients with MAFLD and MAFLD-associated HCC by immunohistochemistry. Results: Mild obesity, spontaneous hyperlipidaemia, glucose intolerance and insulin resistance were characteristic of 36-week-old alb-myctg mice. Middle-aged alb-myctg exhibited liver steatosis and increased triglyceride content. Liver injury and inflammation were associated with elevated ALT, an upregulation of ER-stress response and increased ROS production, collagen deposition and compensatory proliferation. At 52 weeks, 20% of transgenic mice developed HCC. WD feeding exacerbated metabolic abnormalities, steatohepatitis, fibrogenesis and tumor prevalence. Therapeutic use of metformin partly attenuated the spontaneous MAFLD phenotype of alb-myctg mice. Importantly, upregulation and nuclear localization of c-MYC were characteristic of patients with MAFLD and MAFLD-related HCC. Conclusions: A novel function of c-MYC in MAFLD progression was identified opening new avenues for preventative strategies.
- Published
- 2022
50. A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy
- Author
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Guo, Feifei, primary, Estévez-Vázquez, Olga, additional, Benedé-Ubieto, Raquel, additional, Maya-Miles, Douglas, additional, Zheng, Kang, additional, Gallego-Durán, Rocío, additional, Rojas, Ángela, additional, Ampuero, Javier, additional, Romero-Gómez, Manuel, additional, Philip, Kaye, additional, Egbuniwe, Isioma U., additional, Chen, Chaobo, additional, Simon, Jorge, additional, Delgado, Teresa C., additional, Martínez-Chantar, María Luz, additional, Sun, Jie, additional, Reissing, Johanna, additional, Bruns, Tony, additional, Lamas-Paz, Arantza, additional, Moral, Manuel Gómez del, additional, Woitok, Marius Maximilian, additional, Vaquero, Javier, additional, Regueiro, José R., additional, Liedtke, Christian, additional, Trautwein, Christian, additional, Bañares, Rafael, additional, Cubero, Francisco Javier, additional, and Nevzorova, Yulia A., additional
- Published
- 2021
- Full Text
- View/download PDF
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