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1. Long-term inhaled corticosteroid treatment in patients with chronic obstructive pulmonary disease, cardiovascular disease, and a recent hospitalised exacerbation: The ICSLIFE pragmatic, randomised controlled study

Author

Schipani, Giuseppina, Incalzi, Raffaele Antonello, Rogliani, Paola, Ceriana, Piero, Spanevello, Antonio, Balbi, Bruno, Foschino, Maria Pia, Scichilone, Nicola, Para, Ombretta, Nozzoli, Carlo, Dentali, Francesco, Beghè, Bianca, Milanese, Manlio, Monaco, Eugenia, Corsico, Angelo Guido, Facciolongo, Nicola, Barbetta, Carlo, Bonifazi, Martina, Romagnoli, Micaela, Pelaia, Corrado, di Marco, Fabiano, Bianco, Andrea, Papi, Alberto, Maniscalco, Mauro, Bargagli, Elena, Crimi, Claudia, Santus, Pierachille, Tazzari, Enea, Ronzoni, Luca, Santoli, Federica, Molino, Antonio, Marvisi, Maurizio, Patella, Vincenzo, Aliani, Maria, Forini, Giacomo, Bandiera, Valeria, Baraldi, Federico, D'Anna, Silvestro Ennio, Carone, Mauro, Scioscia, Giulia, and Fabbri, Leonardo M

Published
2024
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2. Severe Asthma Network Italy Definition of Clinical Remission in Severe Asthma: A Delphi Consensus

Author

Canonica, Giorgio Walter, Blasi, Francesco, Carpagnano, Giovanna Elisiana, Guida, Giuseppe, Heffler, Enrico, Paggiaro, Pierluigi, Allegrini, Chiara, Antonelli, Andrea, Aruanno, Arianna, Bacci, Elena, Bagnasco, Diego, Beghè, Bianca, Bonavia, Marco, Bonini, Matteo, Brussino, Luisa, Caiaffa, Maria Filomena, Calabrese, Cecilia, Camiciottoli, Gianna, Caminati, Marco, Caruso, Cristiano, Cavallini, Mirta, Chieco Bianchi, Fulvia, Conte, Maria Elisabetta, Corsico, Angelo Guido, Cosmi, Lorenzo, Costantino, Mariateresa, Costanzo, Giulia, Crivellaro, Mariaangiola, D'Alò, Simona, D'Amato, Mariella, Detoraki, Aikaterini, Di Proietto, Maria Carmela, Facciolongo, Nicola Cosimo, Ferri, Sebastian, Fierro, Vincenzo, Foschino, Maria Pia, Latorre, Manuela, Lombardi, Carlo, Macchia, Luigi, Milanese, Manlio, Montagni, Marcello, Parazzini, Elena Maria, Parente, Roberta, Passalacqua, Giovanni, Patella, Vincenzo, Pelaia, Girolamo, Pini, Laura, Puggioni, Francesca, Ricciardi, Luisa, Ridolo, Erminia, Rolo, Joyce, Scichilone, Nicola, Scioscia, Giulia, Senna, Gianenrico, Solidoro, Paolo, Varricchi, Gilda, Vianello, Andrea, Yacoub, Mona Rita, and Yang, Baoran

Published
2023
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3. Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Author

Pohl, Wolfgang, Doberer, Daniel, Martinot, Jean Benoit, Deschampheleire, Maud, Himpe, Ulrike, Chapman, Kenneth, Cheema, Amarjit, Dorscheid, Delbert, Ramsey, Clare, Rolf, Jeffrey, Walker, Brandie, Olivenstein, Ronald, Poirier, Claude, Larivee, Pierre, Bjerrum, Anne Sofie, Titlestad, Ingrid, Hilberg, Ole, Kilpeläinen, Maritta, Bonniaud, Philippe, Taillé, Camille, Tiotiu, Iuliana-Angelica, Girodet, Pierre-Olivier, Blanc, François-Xavier, Pradelli, Johana, Didier, Alain, Nocent Ejnaini, Cecilia, Deslee, Gaetan, Pison, Christophe, Douadi, Youcef, Mahay, Guillaume, Devouassoux, Gilles, Melloni, Boris, Roux, Pauline-Marie, Bourdin, Arnaud, Fry, Stephanie, Schaum, Thomas, Schulz, Christian, Skowasch, Dirk, Taube, Christian, Welte, Tobias, Gleiber, Wolfgang, Brehler, Randolf, Schreiber, Jens, Schuette, Wolfgang, Kronsbein, Juliane, Bonnet, Reiner, Beck, Ekkehard, Lacedonia, Donato, Senna, Gianenrico, Caruso, Cristiano, Crimi, Nunzio, Blasi, Francesco, Santus, Pierachille, Canonica, Giorgio Walter, Guarnieri, Gabriella, Pelaia, Girolamo, Milanese, Manlio, Micheletto, Claudio, Corsico, Angelo Guido, Scichilone, Nicola, Spadaro, Giuseppe, Langeveld, Bas, Holters, Jurgen, Willem van den Berg, Jan, Smit, Arthur, Conemans, Lennart, van Veen, Helena, Staaks, Gerald, Lehmann, Sverre, Echave-Sustaeta, Jose Maria, Ribas, Christian Domingo, de Luiz Martinez, Gustavo, Gonzalez Perez, Ruperto, Garcia Rivero, Juan Luis, Gall, Xavier Muñoz, Soto Campos, Jose Gregorio, Mozo, Paloma Campo, Pan, Carmen Vidal, Fernandez, Ana Gomez-Bastero, Tellez, Sergio Campos, Rivera, Carlos Martinez, Bobolea, Irina Diana, Guerrero, Raquel Morillo, Garcia, Ismael Ali, Rodriguez Hermosa, Juan Luis, Stenfors, Nikolai, Tunsäter, Alf, Curiac, Dan, von Garnier, Christophe, Leuppi, Joerg, Schmid-Grendelmeier, Peter, Nasser, Shuaib, Chaudhuri, Rekha, Nordstrom, Monica, Saralaya, Dinesh, Pfeffer, Paul, Mansur, Adel, Short, Philip, Wenzel, Sally, Cherry, William Brett, Zafra, Heidi, Gonzalez, Erika, Soong, Weily, Davis, Benjamin, Kao, Neil, Hussain, Iftikhar, Maselli Caceres, Diego Jose, Harris, James, Calhoun, William, Rodicio, Ileana, Kaufman, David, Moss, Mark, Sztejman, Eric, DeLeon, Samuel, Sumino, Kaharu, Kashyap, Ravindra, Leflein, Jeffrey, Hajal, Rizan, Fakih, Faisal, Hill, David, Lin, Robert, Jarratt, Mikell, Subramaniam, Vijay, Sussman, Robert, Mumneh, Nayla, Reibman, Joan, Darveaux, Jared, Tan, Ricardo, Tanus, Tonny, Sikand, Vinay, Marshall, Gailen, Mehta, Hemalini, Cole, Jeremy, Goodman, Brad, Goss, Deborah, Bardelas, Jose, Milstone, Aaron, Mehta, Vinay, Clore, Lee, Millard, Mark, Palumbo, Michael, Puppala, Dileep, Leong, Mila, Prenner, Bruce, Robinette, Emory, Heidarian Raissy, Hengameh, Fost, David, Pleskow, Warren, Marcus, Michael, Ilowite, Jonathan, Moore, Wendy, Steven, Gary, De la Cruz, Luis, Chupp, Geoffrey, Berger, William, Randolph, Christopher, Holguin, Fernando, Kureishy, Shahrukh, Campbell, Edward, Peche, Rudi, Pini, Laura, Papi, Alberto, Beghé, Bianca, Peveri, Silvia, Henriquez Santa, Aythamy, Ramos Gonzalez, Jacinto, Vinge, Ines, St. John, Roy, Louis, Renaud, Harrison, Tim W., Chanez, Pascal, Menzella, Francesco, Philteos, George, Cosio, Borja G., Lugogo, Njira L., de Luiz, Gustavo, Burden, Annie, Adlington, Timothy, Keeling, Nanna, Kwiatek, Justin, and Garcia Gil, Esther

Published
2023
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4. Defining a Severe Asthma Super-Responder: Findings from a Delphi Process

Author

Mansur, Adel, Detoraki, Aikaterini, Altraja, Alan, James, Alan, Nanzer-Kelly, Alexandra, Côté, Andréanne, Menzies-Gow, Andrew, Papaioannou, Andriana, Cheffins, Anne-Maree, Bourdin, Arnaud, Mahboub, Bassam, Lipworth, Brian, Celis-Preciado, Carlos Andrés, Torres-Duque, Carlos, Bucca, Caterina, Porsbjerg, Celeste, Ulrik, Charlotte, Corrigan, Chris, Taube, Christian, Farah, Claude, Katelaris, Constance, Langton, David, Ryan, Dermot, Larenas-Linnemann, Désirée, Zervas, Eleftherios, Heffler, Enrico, Hoyte, Flavia, Puggioni, Francesca, Christoff, George, Canonica, Giorgio Walter, Carpagnano, Giovanna Elisiana, Guida, Giuseppe, Katsoulotos, Gregory, Brusselle, Guy, Rupani, Hitashi, Jersmann, Hubertus, Clifton, Ian, Dhariwal, Jaideep, Fingleton, James, Duke, Jane, Rimmer, Janet, Douglass, Jo, Fonseca, João, van Boven, Job, Corless, John, Harrington, John, Maspero, Jorge, Miguel, José Luis, Pipatvech, Kanok, Kenny, Karrinda, Chapman, Kenneth, Kostikas, Konstantinos, Lehtimäki, Lauri, Chung, Li Ping, Heaney, Liam, Hang, Liang-Wen, Boulet, Louis-Philippe, Perez-de-Llano, Luis, Ricciardi, Luisa, Idrees, Majdy, Milanese, Manlio, Conte, Maria Elisabetta, Costantino, Maria Teresa, Siyue, Mariko Koh, Fitzgerald, Mark, Hew, Mark, Peters, Matthew, Tsai, Ming-Ju, Patel, Mitesh, Khan, Mohammad Hashim, Sadatsafavi, Mohsen, Al-Ahmad, Mona, Yacoub, Mona-Rita, De Gennaro, Mónica, Radhakrishna, Naghmeh, Hanania, Nicola Alexander, Papadopoulos, Nikolaos, Lugogo, Njira, Linaker, Norma, Crimi, Nunzio, Dennison, Paddy, Nair, Parameswaran, Mitchell, Patrick David, O’Byrne, Paul, Pfeffer, Paul, Kauppi, Paula, Hughes, Pauline, Middleton, Peter, Wark, Peter, Bardin, Philip, Fu, Pin-Kuei, Akuthota, Praveen, Chaudhuri, Rekha, Campos, Ricardo, Al-Lehebi, Riyard, Parente, Roberta, Francisco, Rovira, Wenzel, Sally, Pierachille, Santus, Pawar, Shrikant, Loukides, Stelios, Fowler, Stephen, Mackenzie, Tara, Brown, Thomas, Lee Tan, Tze, Björnsdóttir, Unnur, McDonald, Vanessa, Lawriwskyj, Veronica, Backer, Vibeke, Vasileva, Violina, Chien, Ying-Chun, Harrington, Zinta, Upham, John W., Le Lievre, Chantal, Jackson, David J., Masoli, Matthew, Wechsler, Michael E., and Price, David B.

Published
2021
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5. Severe asthma: One disease and multiple definitions

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Giovanna Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Lombardi, Carlo, Spadaro, Giuseppe, Detoraki, Caterina, Menzella, Francesco, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, D’Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D’Amato, Verrillo, Maria Vittoria, Rolla, Giovanni, Brussino, Luisa, Frazzetto, Agata Valentina, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Senna, Gianenrico, Caminati, Marco, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D’Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Paggiaro, Pierluigi, Latorre, Manuela, Folli, Chiara, Testino, Elisa, Bassi, Arianna, Milanese, Manlio, Heffler, Enrico, Manfredi, Andrea, Riccio, Anna Maria, De Ferrari, Laura, Blasi, Francesco, Canevari, Rikki Frank, Canonica, Giorgio Walter, and Passalacqua, Giovanni

Published
2021
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6. Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial

Author

Pohl, Wolfgang, Voves, Robert, Deschampheleire, Maud, Louis, Renaud, Martinot, Jean-Benoit, Peché, Rudi, Chapman, Kenneth, Cheema, Amarjit, Dorscheid, Delbert, FitzGerald, J. Mark, Gagnon, Remi, Killorn, William Patrick, Olivenstein, Ronald, Philteos, George, Ramsey, Clare, Rolf, J. Douglass, Walker, Brandie, Hilberg, Ole, Skjold, Tina, Titlestad, Ingrid, Hakulinen, Auli, Kilpeläinen, Maritta, Ben Hayoun, Michèle, Bonniaud, Philippe, Bourdin, Arnaud, Chanez, Pascal, De Blay, Frédéric, Deslee, Gaëtan, Devouassoux, Gilles, Didier, Alain, Douadi, Youcef, Fry, Stéphanie, Garcia, Gilles, Girodet, Pierre-Olivier, Leroyer, Christophe, Magnan, Antoine, Mahay, Guillaume, Nocent, Cécilia, Pison, Christophe, Roux, Pauline-Marie, Taillé, Camille, Tiotiu, Juliana-Angelica, Beck, Ekkehard, Jandl, Margret, Kaehler, Christian, Kässner, Frank, Koesters, Frank, Kronsbein, Juliane, Schaum, Thomas, Schulz, Christian, Skowasch, Dirk, Taube, Christian, Welte, Tobias, de Roux, Andrés, Beghé, Bianca, Blasi, Francesco, Canonica, Giorgio Walter, Carpagnano, Giovanna, Caruso, Cristiano, Corsico, Angelo Guido, Constantino, Elio, Crimi, Nunzio, Maestrelli, Piero, Menzella, Francesco, Milanese, Manlio, Papi, Alberto, Pelaia, Girolamo, Pini, Laura, Santus, Pierachille, Savi, Eleonora, Scichilone, Nicola, Senna, Gianenrico, Spadaro, Giuseppe, Vaghi, Adriano, Gans, Steven, Hölters, Jurgen, Langeveld, B., Pieters, Willem, Staaks, G.H.A., van Veen, Ilonka, van den Berg, J.W.K., Einvik, Gunnar, Lehmann, Sverre, Ali García, Ismael, Almonacid, Carlos, Bobolea, Irina, Campo Mozo, Paloma, de Luiz, Gustavo, Domingo Ribas, Christian, Echave-Sustaeta María-Tomé, José María, García Rivero, Juan Luis, García-Cosío Piqueras, Borja, Gómez-Bastero Fernández, Ana, González Pérez, Ruperto, Henríquez Santa, Aythamy, Martínez Rivera, Carlos, Muñoz Gall, Xavier, Ramos, Jacinto, Gregorio Soto Campos, Jose, Vidal Pan, Carmen, Stenfors, Nikolai, Tunsäter, Alf, Vinge, Ines, Chaudhuri, Rekha, Harrison, Timothy, Mansur, Adel, Nasser, Shuaib, Nordstrom, Monica, Pfeffer, Paul, Saralaya, Dinesh, Short, Philip, Adlakha, Arun, Alpan, Oral, Averill, Francis, Badhwar, Anil, Bardelas, Jose, Baxter, Barbara, Bensch, George, Berger, William, Bernstein, Jonathan, Bridges, Tracy, Brimeyer, Ryan, Calhoun, William, Campbell, Edward, Cherry, William Brett, Chupp, Geoffrey, Clore, Lee, Cohn, John, Cole, Jeremy, Condemi, John, Cury, James, Davis, Benjamin, DeLeon, Samuel, Delacruz, Luis, Diaz, Joseph, Erb, David, Eziri, Emeka, Fakih, Faisal, Fiedler, Douglas, Fost, David, Fritz, Stephen, Gonzalez, Erika, Goodman, Brad, Gottlieb, Peter, Gottschlich, Gregory, Gower, Richard, Hajal, Rizan, Harris, James, Heidarian-Raissy, Hengameh, Heyder, Albrecht, Hill, David, Holguin, Fernando, Hussain, Iftikhar, Illowite, Jonathan, Jacobs, Joshua, Jarratt, Mikell, Kaiser, Harold, Kao, Neil, Kashyap, Ravindra, Kaufman, David, Kent, Edward, Kim, Kenneth, Klein, Ryan, Kraft, Monica, Kono, Ritsu, Kureishy, Shahrukh, Leflein, Jeffrey, Leong, Mila, Li, Huamin, Lin, Robert, Lugogo, Njira, Marcus, Michael, Maselli Caceres, Diego Jose, Mehta, Vinay, Mello, Curtis, Millard, Mark, Milstone, Aaron, Mohan, Arjun, Moore, Wendy, Moss, Mark, Mumneh, Nayla, O'Brien, Thomas, Ostransky, David, Palumbo, Michael, Parikh, Purvi, Parikh, Sudhir, Patel, Amit, Perez, Guido, Pleskow, Warren, Prenner, Bruce, Puppala, Dileep, Ramey, John, Reibman, Joan, Reyes, Ramon, Robinette, Emory, Rodicio, Ileana, Ryan, Stephen, Sekhsaria, Sudhir, Sigal, Barry, Sikand, Vinay, Soong, Weily, Spangenthal, Selwyn, St. John, Roy, Steven, Gary, Subramaniam, Vijay, Sumino, Kaharu, Sztejman, Eric, Tan, Ricardo A., Tanus, Tonny, Thompson, Charles, Thornblade, Carl, Villareal, Manuel, Wenzel, Sally, Zafra, Heidi, Ziedalski, Tomasz, Harrison, Tim W, Cosio, Borja G, Lugogo, Njira L, Burden, Annie, McDermott, Lawrence, Garcia Gil, Esther, and Zangrilli, James G

Published
2021
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8. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Paggiaro, Pierluigi, Latorre, Manuela, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Spadaro, Giuseppe, Detoraki, Caterina, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Colombo, Gisella, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, Blasi, Francesco, D'Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D'Amato, Verrillo, Maria Vittoria, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Aletti, Eleonora, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D'Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Povero, Massimiliano, Pradelli, Lorenzo, Brussino, Luisa, Rolla, Giovanni, Caminati, Marco, Menzella, Francesco, Heffler, Enrico, Canonica, Giorgio Walter, Senna, Gianenrico, Milanese, Manlio, Lombardi, Carlo, Bucca, Caterina, Manfredi, Andrea, Canevari, Rikki Frank, and Passalacqua, Giovanni

Published
2021
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9. Evaluation of Clinical Remission in Best-Performing Severe Asthmatic Patients Treated for Three Years with Mepolizumab.

Author

Bagnasco, Diego, Bondi, Benedetta, Caminati, Marco, Nicola, Stefania, Pini, Laura, Milanese, Manlio, Brussino, Luisa, Senna, Gianenrico, Canonica, Giorgio Walter, and Braido, Fulvio

Subjects
DISEASE remission, FORCED expiratory volume, ASTHMA, STEROID drugs
Abstract

Background: In its severe form, where possible, asthma is treated using biological drugs in order to reduce, as much as possible, the use of systemic steroids. Mepolizumab is effective for severe asthma based on key outcomes such as exacerbation and steroid dependence. Its efficacy in terms of the criteria for clinical remission in the short and long term has become of interest. Objective: We aimed to evaluate the effect of mepolizumab in the achievement of clinical remission after 3 years of administration. Methods: In this study, 71 patients who continued mepolizumab for 3 years were assessed for clinical remission according to six different published sets of remission criteria. Results: According to the criteria, 39–52% of patients experienced complete remission in the first year, increasing to 51–73% at 3 years. By classifying patients according to partial and complete remission criteria, proposed by the SANI, we observe 22% of patients in partial remission at one year, achieving complete remission after three years. The baseline factors associated with earlier remission were a higher FEV1, if we consider classifications requiring an FEV1 ≥ 80%, a low OCS dose, and low FeNO levels, in the patients requiring FEV1 stabilization. Conclusions: Clinical remission is possible for patients treated with mepolizumab. The observations at three years compared with the first year indicated that the factors negatively affecting remission delayed rather than prevented it. Earlier treatment could increase the chances of remission. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

Author

Canonica, Giorgio Walter, Blasi, Francesco, Paggiaro, Pierluigi, Senna, Gianenrico, Passalacqua, Giovanni, Spanevello, Antonio, Aliberti, Stefano, Bagnasco, Diego, Bonavia, Marco, Bonini, Matteo, Brussino, Luisa, Bucca, Caterina, Caiaffa, Maria F., Calabrese, Cecilia, Camiciottoli, Gianna, Caminati, Marco, Carpagnano, Giovanna E., Caruso, Cristiano, Centanni, Stefano, Conte, Maria E., Corsico, Angelo G., Cosmi, Lorenzo, Costantino, Maria T., Crimi, Nunzio, D’Alò, Simona, D'Amato, Maria, Del Giacco, Stefano, Farsi, Alessandro, Favero, Elisabetta, Foschino Barbaro, Maria P., Guarnieri, Gabriella, Guida, Giuseppe, Latorre, Manuela, Lo Cicero, Salvatore, Lombardi, Carlo, Macchia, Luigi, Mazza, Francesco, Menzella, Francesco, Milanese, Manlio, Montagni, Marcello, Montuschi, Paolo, Nucera, Eleonora, Parente, Roberta, Patella, Vincenzo, Pelaia, Girolamo, Pini, Laura, Puggioni, Francesca, Ricciardi, Luisa, Ricciardolo, Fabio L.M., Richeldi, Luca, Ridolo, Erminia, Rolla, Giovanni, Santus, Pierachille, Scichilone, Nicola, Spadaro, Giuseppe, Vianello, Andrea, Viviano, Vittorio, Yacoub, Mona R., Zappa, Maria C., and Heffler, Enrico

Published
2020
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11. Efficacy of Benralizumab in severe asthma in real life and focus on nasal polyposis

Author

Bagnasco, Diego, Brussino, Luisa, Bonavia, Marco, Calzolari, Elisa, Caminati, Marco, Caruso, Cristiano, D'Amato, Maria, De Ferrari, Laura, Di Marco, Fabiano, Imeri, Gianluca, Di Bona, Danilo, Gilardenghi, Andrea, Guida, Giuseppe, Lombardi, Carlo, Milanese, Manlio, Nicolini, Antonello, Riccio, Anna Maria, Rolla, Giovanni, Santus, Pierachille, Senna, Gianenrico, and Passalacqua, Giovanni

Published
2020
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15. Prevalence of Long COVID Symptoms Related to SARS-CoV-2 Strains

Author

Aloè, Teresita, primary, Novelli, Federica, additional, Puppo, Gianfranco, additional, Pinelli, Valentina, additional, Barisione, Emanuela, additional, Trucco, Elisa, additional, Costanzo, Roberta, additional, Covesnon, Maria Grazia, additional, Grillo, Federica, additional, Zoccali, Patrizia, additional, Milanese, Manlio, additional, Maniscalco, Sara, additional, Tagliabue, Elena, additional, Piroddi, Ines Maria Grazia, additional, Venturi, Simonetta, additional, Serra, Maria, additional, Scordamaglia, Francesca, additional, Ferrari, Marta, additional, and Serafini, Antonella, additional

Published
2023
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17. The impact of psychological health in African American young adults on asthma control: why is phenotyping still an unmet need? Suggestions from a multidisciplinary 'Stress-Asthma Working Group'.

Author

Liccardi, Gennaro, Martini, Matteo, Bilò, Maria Beatrice, Milanese, Manlio, Baiardini, Ilaria, Liccardi, Maria Vittoria, and Rogliani, Paola

Subjects
YOUNG adults, PSYCHOLOGICAL factors, AFRICAN Americans, ASTHMA, MUSCARINIC antagonists
Abstract

The letter to the editor discusses the association between psychological health and asthma control in African American young adults. The authors of the letter agree with a previous study that found a high rate of psychological disorders in young adults with poorly controlled asthma. They suggest that the relationship between psychological health and asthma control may be bidirectional and propose that the parasympathetic system may play a role in triggering bronchial obstruction in asthmatic individuals. The authors also recommend considering the use of long-acting muscarinic antagonists (LAMAs) in patients with increased basal cholinergic activity. They conclude by emphasizing the need for further research to better understand the complex relationship between anxiety and asthma. [Extracted from the article]

Published
2024
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18. COVID-19 after 2 Years from Hospital Discharge: A Pulmonary Function and Chest Computed Tomography Follow-Up Study.

Author

Mennella, Simone, Alicino, Cristiano, Anselmo, Marco, Carrega, Giuliana, Ficarra, Gianluca, Garra, Luca, Gastaldo, Alessandro, Gnerre, Paola, Lillo, Flavia, Tassara, Rodolfo, Terrile, Anna, and Milanese, Manlio

Subjects
PATIENT aftercare, COVID-19, CHEST X rays, SCIENTIFIC observation, POST-acute COVID-19 syndrome, LUNGS, SEVERITY of illness index, PULMONARY function tests, DESCRIPTIVE statistics, COMPUTED tomography, SPIROMETRY, DISCHARGE planning, LONGITUDINAL method
Abstract

Introduction: Serial follow-up with pulmonary function testing (PFT) and chest computed tomography (CT) after severe COVID-19 are recommended. As a result, many longitudinal studies have been published on COVID-19 of different grade of severity up to 1-year follow-up. Therefore, we aimed at a long-term observational study throughout 2 years after severe COVID-19. Methods: Severe COVID-19 patients were consecutively recruited after hospital discharge between March and June 2020 and prospectively followed up for 24 months, with mMRC dyspnea scale and PFT at 6, 12, and 24 months. Chest CT was performed when clinically indicated. Results: One hundred one patients enrolled completed the observational study. At 24 months, those with reduced total lung capacity (TLC) were 16%, associated with fibrotic ground glass opacity (GGO) and mMRC score >1, respectively, in 75% and 69% of them. At 24 months, those with a reduced diffusing capacity of the lung for CO were 41%, associated with fibrotic GGO and mMRC score >1, respectively, in 53% and 22% of them. Conclusion: Two years after hospitalization for severe COVID-19, a non-negligible number of patients still suffer from "long COVID" due to respiratory damage. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Severe Asthma Standard-of-Care Background Medication Reduction With Benralizumab: ANDHI in Practice Substudy

Author

Louis, Renaud, primary, Harrison, Tim W., additional, Chanez, Pascal, additional, Menzella, Francesco, additional, Philteos, George, additional, Cosio, Borja G., additional, Lugogo, Njira L., additional, de Luiz, Gustavo, additional, Burden, Annie, additional, Adlington, Timothy, additional, Keeling, Nanna, additional, Kwiatek, Justin, additional, Garcia Gil, Esther, additional, Pohl, Wolfgang, additional, Doberer, Daniel, additional, Martinot, Jean Benoit, additional, Deschampheleire, Maud, additional, Himpe, Ulrike, additional, Chapman, Kenneth, additional, Cheema, Amarjit, additional, Dorscheid, Delbert, additional, Ramsey, Clare, additional, Rolf, Jeffrey, additional, Walker, Brandie, additional, Olivenstein, Ronald, additional, Poirier, Claude, additional, Larivee, Pierre, additional, Bjerrum, Anne Sofie, additional, Titlestad, Ingrid, additional, Hilberg, Ole, additional, Kilpeläinen, Maritta, additional, Bonniaud, Philippe, additional, Taillé, Camille, additional, Tiotiu, Iuliana-Angelica, additional, Girodet, Pierre-Olivier, additional, Blanc, François-Xavier, additional, Pradelli, Johana, additional, Didier, Alain, additional, Nocent Ejnaini, Cecilia, additional, Deslee, Gaetan, additional, Pison, Christophe, additional, Douadi, Youcef, additional, Mahay, Guillaume, additional, Devouassoux, Gilles, additional, Melloni, Boris, additional, Roux, Pauline-Marie, additional, Bourdin, Arnaud, additional, Fry, Stephanie, additional, Schaum, Thomas, additional, Schulz, Christian, additional, Skowasch, Dirk, additional, Taube, Christian, additional, Welte, Tobias, additional, Gleiber, Wolfgang, additional, Brehler, Randolf, additional, Schreiber, Jens, additional, Schuette, Wolfgang, additional, Kronsbein, Juliane, additional, Bonnet, Reiner, additional, Beck, Ekkehard, additional, Lacedonia, Donato, additional, Senna, Gianenrico, additional, Caruso, Cristiano, additional, Crimi, Nunzio, additional, Blasi, Francesco, additional, Santus, Pierachille, additional, Canonica, Giorgio Walter, additional, Guarnieri, Gabriella, additional, Pelaia, Girolamo, additional, Milanese, Manlio, additional, Micheletto, Claudio, additional, Corsico, Angelo Guido, additional, Scichilone, Nicola, additional, Spadaro, Giuseppe, additional, Langeveld, Bas, additional, Holters, Jurgen, additional, Willem van den Berg, Jan, additional, Smit, Arthur, additional, Conemans, Lennart, additional, van Veen, Helena, additional, Staaks, Gerald, additional, Lehmann, Sverre, additional, Echave-Sustaeta, Jose Maria, additional, Ribas, Christian Domingo, additional, de Luiz Martinez, Gustavo, additional, Gonzalez Perez, Ruperto, additional, Garcia Rivero, Juan Luis, additional, Gall, Xavier Muñoz, additional, Soto Campos, Jose Gregorio, additional, Mozo, Paloma Campo, additional, Pan, Carmen Vidal, additional, Fernandez, Ana Gomez-Bastero, additional, Tellez, Sergio Campos, additional, Rivera, Carlos Martinez, additional, Bobolea, Irina Diana, additional, Guerrero, Raquel Morillo, additional, Garcia, Ismael Ali, additional, Rodriguez Hermosa, Juan Luis, additional, Stenfors, Nikolai, additional, Tunsäter, Alf, additional, Curiac, Dan, additional, von Garnier, Christophe, additional, Leuppi, Joerg, additional, Schmid-Grendelmeier, Peter, additional, Nasser, Shuaib, additional, Chaudhuri, Rekha, additional, Nordstrom, Monica, additional, Saralaya, Dinesh, additional, Pfeffer, Paul, additional, Mansur, Adel, additional, Short, Philip, additional, Wenzel, Sally, additional, Cherry, William Brett, additional, Zafra, Heidi, additional, Gonzalez, Erika, additional, Soong, Weily, additional, Davis, Benjamin, additional, Kao, Neil, additional, Hussain, Iftikhar, additional, Maselli Caceres, Diego Jose, additional, Harris, James, additional, Calhoun, William, additional, Rodicio, Ileana, additional, Kaufman, David, additional, Moss, Mark, additional, Sztejman, Eric, additional, DeLeon, Samuel, additional, Sumino, Kaharu, additional, Kashyap, Ravindra, additional, Leflein, Jeffrey, additional, Hajal, Rizan, additional, Fakih, Faisal, additional, Hill, David, additional, Lin, Robert, additional, Jarratt, Mikell, additional, Subramaniam, Vijay, additional, Sussman, Robert, additional, Mumneh, Nayla, additional, Reibman, Joan, additional, Darveaux, Jared, additional, Tan, Ricardo, additional, Tanus, Tonny, additional, Sikand, Vinay, additional, Marshall, Gailen, additional, Mehta, Hemalini, additional, Cole, Jeremy, additional, Goodman, Brad, additional, Goss, Deborah, additional, Bardelas, Jose, additional, Milstone, Aaron, additional, Mehta, Vinay, additional, Clore, Lee, additional, Millard, Mark, additional, Palumbo, Michael, additional, Puppala, Dileep, additional, Leong, Mila, additional, Prenner, Bruce, additional, Robinette, Emory, additional, Heidarian Raissy, Hengameh, additional, Fost, David, additional, Pleskow, Warren, additional, Marcus, Michael, additional, Ilowite, Jonathan, additional, Moore, Wendy, additional, Steven, Gary, additional, De la Cruz, Luis, additional, Chupp, Geoffrey, additional, Berger, William, additional, Randolph, Christopher, additional, Holguin, Fernando, additional, Kureishy, Shahrukh, additional, and Campbell, Edward, additional

Published
2023
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21. Long-Term Efficacy of Mepolizumab at 3 Years in Patients with Severe Asthma: Comparison with Clinical Trials and Super Responders.

Author

Bagnasco, Diego, Nicola, Stefania, Testino, Elisa, Brussino, Luisa, Pini, Laura, Caminati, Marco, Piccardo, Federica, Canevari, Rikki Frank, Melissari, Laura, Ioppi, Alessandro, Guastini, Luca, Lombardi, Carlo, Milanese, Manlio, Losa, Francesca, Robbiano, Michela, De Ferrari, Laura, Riccio, Anna Maria, Guida, Giuseppe, Bonavia, Marco, and Fini, Donatella

Subjects
ASTHMATICS, CLINICAL trials, NASAL polyps, PHARMACODYNAMICS
Abstract

The efficacy mepolizumab in severe asthmatic patients is proven in the literature. Primarily to study the effect of mepolizumab on exacerbations, steroid dependence, and the continuation of efficacy in the long term. Secondarily to evaluate the effect of the drug on nasal polyps. Analyzing data from SANI (Severe Asthma Network Italy) clinics, we observed severe asthmatic patients treated with mepolizumab 100 mg/4 weeks, for a period of 3 years. 157 patients were observed. Exacerbations were reduced from the first year (−84.6%) and progressively to 90 and 95% in the second and third ones. Steroid-dependent patients decreased from 54% to 21% and subsequently to 11% in the second year and 6% in the third year. Patients with concomitant nasal polyps, assessed by SNOT-22, showed a 49% reduction in value from baseline to the third year. The study demonstrated the long-term efficacy of mepolizumab in a real-life setting. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Pest sensitization to cockroach, mouse, and rat: An Italian multicenter study

Author

Liccardi, Gennaro, primary, Bilò, Maria Beatrice, additional, Calzetta, Luigino, additional, Milanese, Manlio, additional, Martini, Matteo, additional, Bresciani, Megon, additional, Cilia, Marcello, additional, Cucinelli, Francesco, additional, D'Angelo, Romina, additional, Feliziani, Annamaria, additional, Filon, Francesca Larese, additional, Longo, Rocco, additional, Losappio, Laura, additional, Manzotti, Giusy, additional, Minale, Paola, additional, Modica, Stella, additional, Murzilli, Francesco, additional, Musarra, Antonino, additional, Pingitore, Giuseppe, additional, Polillo, Battista Roberto, additional, Puggioni, Francesca, additional, Quercia, Oliviero, additional, Rapone, Carla, additional, and Rogliani, Paola, additional

Published
2022
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23. Pest sensitization to cockroach, mouse, and rat: An Italian multicenter study.

Author

Liccardi, Gennaro, Bilò, Maria Beatrice, Calzetta, Luigino, Milanese, Manlio, Martini, Matteo, Bresciani, Megon, Cilia, Marcello, Cucinelli, Francesco, D'Angelo, Romina, Feliziani, Annamaria, Filon, Francesca Larese, Longo, Rocco, Losappio, Laura, Manzotti, Giusy, Minale, Paola, Modica, Stella, Murzilli, Francesco, Musarra, Antonino, Pingitore, Giuseppe, and Polillo, Battista Roberto

Subjects
COCKROACHES, PESTS, MICE, ALLERGENIC extracts, RATS, CAT diseases
Published
2023
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26. Defining a Severe Asthma Super-Responder: Findings from a Delphi Process

Author

Upham, John W., primary, Le Lievre, Chantal, additional, Jackson, David J., additional, Masoli, Matthew, additional, Wechsler, Michael E., additional, Price, David B., additional, Mansur, Adel, additional, Detoraki, Aikaterini, additional, Altraja, Alan, additional, James, Alan, additional, Nanzer-Kelly, Alexandra, additional, Côté, Andréanne, additional, Menzies-Gow, Andrew, additional, Papaioannou, Andriana, additional, Cheffins, Anne-Maree, additional, Bourdin, Arnaud, additional, Mahboub, Bassam, additional, Lipworth, Brian, additional, Celis-Preciado, Carlos Andrés, additional, Torres-Duque, Carlos, additional, Bucca, Caterina, additional, Porsbjerg, Celeste, additional, Ulrik, Charlotte, additional, Corrigan, Chris, additional, Taube, Christian, additional, Farah, Claude, additional, Katelaris, Constance, additional, Langton, David, additional, Ryan, Dermot, additional, Larenas-Linnemann, Désirée, additional, Zervas, Eleftherios, additional, Heffler, Enrico, additional, Hoyte, Flavia, additional, Puggioni, Francesca, additional, Christoff, George, additional, Canonica, Giorgio Walter, additional, Carpagnano, Giovanna Elisiana, additional, Guida, Giuseppe, additional, Katsoulotos, Gregory, additional, Brusselle, Guy, additional, Rupani, Hitashi, additional, Jersmann, Hubertus, additional, Clifton, Ian, additional, Dhariwal, Jaideep, additional, Fingleton, James, additional, Duke, Jane, additional, Rimmer, Janet, additional, Douglass, Jo, additional, Fonseca, João, additional, van Boven, Job, additional, Corless, John, additional, Harrington, John, additional, Maspero, Jorge, additional, Miguel, José Luis, additional, Pipatvech, Kanok, additional, Kenny, Karrinda, additional, Chapman, Kenneth, additional, Kostikas, Konstantinos, additional, Lehtimäki, Lauri, additional, Chung, Li Ping, additional, Heaney, Liam, additional, Hang, Liang-Wen, additional, Boulet, Louis-Philippe, additional, Perez-de-Llano, Luis, additional, Ricciardi, Luisa, additional, Idrees, Majdy, additional, Milanese, Manlio, additional, Conte, Maria Elisabetta, additional, Costantino, Maria Teresa, additional, Siyue, Mariko Koh, additional, Fitzgerald, Mark, additional, Hew, Mark, additional, Peters, Matthew, additional, Tsai, Ming-Ju, additional, Patel, Mitesh, additional, Khan, Mohammad Hashim, additional, Sadatsafavi, Mohsen, additional, Al-Ahmad, Mona, additional, Yacoub, Mona-Rita, additional, De Gennaro, Mónica, additional, Radhakrishna, Naghmeh, additional, Hanania, Nicola Alexander, additional, Papadopoulos, Nikolaos, additional, Lugogo, Njira, additional, Linaker, Norma, additional, Crimi, Nunzio, additional, Dennison, Paddy, additional, Nair, Parameswaran, additional, Mitchell, Patrick David, additional, O’Byrne, Paul, additional, Pfeffer, Paul, additional, Kauppi, Paula, additional, Hughes, Pauline, additional, Middleton, Peter, additional, Wark, Peter, additional, Bardin, Philip, additional, Fu, Pin-Kuei, additional, Akuthota, Praveen, additional, Chaudhuri, Rekha, additional, Campos, Ricardo, additional, Al-Lehebi, Riyard, additional, Parente, Roberta, additional, Francisco, Rovira, additional, Wenzel, Sally, additional, Pierachille, Santus, additional, Pawar, Shrikant, additional, Loukides, Stelios, additional, Fowler, Stephen, additional, Mackenzie, Tara, additional, Brown, Thomas, additional, Lee Tan, Tze, additional, Björnsdóttir, Unnur, additional, McDonald, Vanessa, additional, Lawriwskyj, Veronica, additional, Backer, Vibeke, additional, Vasileva, Violina, additional, Chien, Ying-Chun, additional, and Harrington, Zinta, additional

Published
2021
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27. Severe asthma: One disease and multiple definitions

Author

Bagnasco, Diego, primary, Paggiaro, Pierluigi, additional, Latorre, Manuela, additional, Folli, Chiara, additional, Testino, Elisa, additional, Bassi, Arianna, additional, Milanese, Manlio, additional, Heffler, Enrico, additional, Manfredi, Andrea, additional, Riccio, Anna Maria, additional, De Ferrari, Laura, additional, Blasi, Francesco, additional, Canevari, Rikki Frank, additional, Canonica, Giorgio Walter, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Giovanna Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Lombardi, Carlo, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Menzella, Francesco, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, D’Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D’Amato, additional, Verrillo, Maria Vittoria, additional, Rolla, Giovanni, additional, Brussino, Luisa, additional, Frazzetto, Agata Valentina, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Senna, Gianenrico, additional, Caminati, Marco, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D’Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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28. Lung function and peak oxygen uptake in chronic obstructive pulmonary disease phenotypes with and without emphysema

Author

Rasch-Halvorsen, O, Hassel, E, Brumpton, B, Jenssen, H, SPRUIT, Martijn A., Langhammer, A, Steinshamn, S, Milanese, Manlio, Pulmonologie, and RS: NUTRIM - R3 - Respiratory & Age-related Health

Subjects
Male, Pulmonology, Pulmonary Function, DYNAMIC HYPERINFLATION, Gastroenterology, EXERCISE CAPACITY, Pulmonary function testing, Medical Conditions, FLOW LIMITATION, Medicine and Health Sciences, Medicine, Lung volumes, Public and Occupational Health, Community Health Services, Dynamic hyperinflation, Health Education, Lung, COPD, Multidisciplinary, medicine.diagnostic_test, Pharmaceutics, VO2 max, Drugs, Middle Aged, Sports Science, Chemistry, medicine.anatomical_structure, Pulmonary Emphysema, Hypertension, Physical Sciences, Female, Research Article, Chemical Elements, Adult, Spirometry, medicine.medical_specialty, Beta-Adrenergic Antagonist Therapy, Science, Chronic Obstructive Pulmonary Disease, INTOLERANCE, DIAGNOSIS, Respiratory Disorders, Bronchodilators, Drug Therapy, Internal medicine, Linear regression, Humans, Sports and Exercise Medicine, Exercise, Aged, Sweden, Emphysema, Pharmacology, business.industry, MORTALITY, Biology and Life Sciences, Physical Activity, medicine.disease, SPIROMETRY, respiratory tract diseases, VENTILATION, Oxygen, Dyspnea, Physical Fitness, VOLUME, Patient Compliance, business, human activities, Receptor Antagonist Therapy
Abstract

Previous studies of associations of forced expiratory lung volume in one second (FEV1) with peak oxygen uptake (VO2peak) in chronic obstructive pulmonary disease (COPD) have not taken sex, age and height related variance of dynamic lung volumes into account. Nor have such demographic spread of spirometric measures been considered in studies comparing VO2peak between COPD phenotypes characterized by degree of emphysema. We aimed to assess the association of FEV1Z-score with VO2peak in COPD (n = 186) and investigate whether this association differs between emphysema (E-COPD) and non-emphysema (NE-COPD) phenotypes. Corresponding assessments using standardized percent predicted FEV1 (ppFEV1) were performed for comparison. Additionally, phenotype related differences in VO2peak were compared using FEV1Z-score and ppFEV1 as alternative expressions of FEV1. E-COPD and NE-COPD were defined by transfer factor of the lung for carbon monoxide below and above lower limits of normal (LLN), respectively. The associations were assessed in linear regression models. One unit reduction in FEV1Z-score was associated with 1.9 (95% CI 1.4, 2.5) ml/kg/min lower VO2peak. In stratified analyses, corresponding estimates were 2.2 (95% CI 1.4, 2.9) and 1.2 (95% CI 0.2, 2.2) ml/kg/min lower VO2peak in E-COPD and NE-COPD, respectively. The association did not differ statistically by COPD phenotype (p-value for interaction = 0.153). Similar estimates were obtained in analyses using standardized ppFEV1. Compared to NE-COPD, VO2peak was 2.2 (95% CI 0.8, 3.6) and 2.1 (95% CI 0.8, 3.5) ml/kg/min lower in E-COPD when adjusted for FEV1Z-score and ppFEV1, respectively. In COPD, FEV1Z-score is positively associated with VO2peak. This association was stronger in E-COPD but did not differ statistically by phenotype. Both the association of FEV1 with VO2peak and the difference in VO2peak comparing COPD phenotypes seems independent of sex, age and height related variance in FEV1. Mechanisms leading to reduction in FEV1 may contribute to lower VO2peak in E-COPD.

Published
2021

29. Mild/Moderate Asthma Network in Italy (MANI): a long-term observational study.

Author

Braido, Fulvio, Blasi, Francesco, Canonica, Giorgio Walter, Paggiaro, Pierluigi, Beghè, Bianca, Bonini, Matteo, Carpagnano, Giovanna Elisiana, Del Giacco, Stefano, Lavorini, Federico, Milanese, Manlio, Patella, Vincenzo, Santus, Pierachille, Contoli, Marco, Allegrini, Chiara, Baiardini, Ilaria, Bonzano, Laura, Caiaffa, Maria Filomena, Castelnuovo, Paolo, Corsico, Angelo Guido, and Cosmi, Lorenzo

Subjects
ASTHMA, ASTHMATICS, SCIENTIFIC observation, MEDICAL research, CLINICAL immunology, WHEEZE
Abstract

The prevalence of asthma in Italy is estimated to be around 4%; it affects approximately 2,000,000 citizens, and up to 80–90% of patients have mild-to-moderate asthma. Despite the clinical relevance of mild-to-moderate asthma, longitudinal observational data are very limited, including data on disease progression (worsening vs. improvement), the response to treatment, and prognosis. Studies are needed to develop long-term, observational, real-life research in large cohorts. The primary outcomes of this study will be based on prospective observation and the epidemiological evolution of mild and moderate asthma. Secondary outcomes will include patient-reported outcomes, treatments over time, disease-related functional and inflammatory patterns, and environmental and life-style influences. This study, called the Mild/Moderate Asthma Network of Italy (MANI), is a research initiative launched by the Italian Respiratory Society and the Italian Society of Allergology, Asthma and Clinical Immunology. MANI is a cluster-based, real world, cross-sectional, prospective, observational cohort study that includes 20,000 patients with mild-to-moderate asthma. (ClinicalTrials.gov Identifier: NCT04796844). Despite advances in asthma care, several research gaps remain to be addressed through clinical research. This study will add important new knowledge about long-term disease history, the transferability of clinical research results to daily practice, the efficacy of currently recommended strategies, and their impact on the burden and evolution of the disease. MANI: Mild/Moderate Asthma Network of Italy SANI: Severe Asthma Network Italy GINA: Global Initiative for Asthma SABA: short acting β2-agonists ICS: inhaled corticosteroids CRF: Case Report Form [ABSTRACT FROM AUTHOR]

Published
2022
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33. A prevalent exposure to male dog is a risk factor for exclusive allergic sensitization to Can f 5: An Italian multicenter study

Author

Baiardini, Ilaria, Baldo, Ermanno, Bucca, Caterina, Canonica, Giorgio Walter, Heffler, Enrico, La Grutta, Stefania, Rolla, Giovanni, Rossi, Oliviero, Senna, Gianenrico, Sposato, Bruno, Tesi, Carlo Filippo, Viegi, Giovanni, Liccardi, Gennaro, Calzetta, Luigino, Bilò, Maria Beatrice, Brusca, Ignazio, Cecchi, Lorenzo, Costantino, Maria Teresa, Da Re, Mirella, Buzzulini, Francesca, Giani, Mauro, Lombardi, Carlo, Meneguzzi, Giorgia, Meriggi, Antonio, Milanese, Manlio, Onida, Rosa, Patella, Vincenzo, Pignatti, Patrizia, Quercia, Oliviero, Ridolo, Erminia, Sabatino, Giusy, Sacerdoti, Carlo, Savi, Eleonora, Scala, Enrico, Steinhilber, Gundi, Villalta, Danilo, Passalacqua, Giovanni, and Rogliani, Paola

Published
2020
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34. Gli esami di funzionalità respiratoria nell’era pandemica COVID-19. Un aggiornamento.

Author

Milanese, Manlio, Maniscalco, Mauro, Cerveri, Isa, Corsico, Angelo Guido, Palange, Paolo, Vancheri, Carlo, Carone, Mauro, Micheletto, Claudio, Piccioni, Pavilio, Renda, Teresa, Scala, Raffaele, Tognella, Silvia, and Vaghi, Adriano

Abstract

In June 2020, indications were developed for the resumption of pulmonary function testing in the course of a SARS-CoV-2 pandemic, in support of national, regional and company directives, as well as for pulmonologists dedicated to pulmonary function laboratories. The present document represents an update of the previous one in the light of new knowledge and the current SARS-CoV-2 epidemiological situation. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial

Author

Harrison, Tim W, primary, Chanez, Pascal, additional, Menzella, Francesco, additional, Canonica, Giorgio Walter, additional, Louis, Renaud, additional, Cosio, Borja G, additional, Lugogo, Njira L, additional, Mohan, Arjun, additional, Burden, Annie, additional, McDermott, Lawrence, additional, Garcia Gil, Esther, additional, Zangrilli, James G, additional, Pohl, Wolfgang, additional, Voves, Robert, additional, Deschampheleire, Maud, additional, Martinot, Jean-Benoit, additional, Peché, Rudi, additional, Chapman, Kenneth, additional, Cheema, Amarjit, additional, Dorscheid, Delbert, additional, FitzGerald, J. Mark, additional, Gagnon, Remi, additional, Killorn, William Patrick, additional, Olivenstein, Ronald, additional, Philteos, George, additional, Ramsey, Clare, additional, Rolf, J. Douglass, additional, Walker, Brandie, additional, Hilberg, Ole, additional, Skjold, Tina, additional, Titlestad, Ingrid, additional, Hakulinen, Auli, additional, Kilpeläinen, Maritta, additional, Ben Hayoun, Michèle, additional, Bonniaud, Philippe, additional, Bourdin, Arnaud, additional, De Blay, Frédéric, additional, Deslee, Gaëtan, additional, Devouassoux, Gilles, additional, Didier, Alain, additional, Douadi, Youcef, additional, Fry, Stéphanie, additional, Garcia, Gilles, additional, Girodet, Pierre-Olivier, additional, Leroyer, Christophe, additional, Magnan, Antoine, additional, Mahay, Guillaume, additional, Nocent, Cécilia, additional, Pison, Christophe, additional, Roux, Pauline-Marie, additional, Taillé, Camille, additional, Tiotiu, Juliana-Angelica, additional, Beck, Ekkehard, additional, Jandl, Margret, additional, Kaehler, Christian, additional, Kässner, Frank, additional, Koesters, Frank, additional, Kronsbein, Juliane, additional, Schaum, Thomas, additional, Schulz, Christian, additional, Skowasch, Dirk, additional, Taube, Christian, additional, Welte, Tobias, additional, de Roux, Andrés, additional, Beghé, Bianca, additional, Blasi, Francesco, additional, Carpagnano, Giovanna, additional, Caruso, Cristiano, additional, Corsico, Angelo Guido, additional, Constantino, Elio, additional, Crimi, Nunzio, additional, Maestrelli, Piero, additional, Milanese, Manlio, additional, Papi, Alberto, additional, Pelaia, Girolamo, additional, Pini, Laura, additional, Santus, Pierachille, additional, Savi, Eleonora, additional, Scichilone, Nicola, additional, Senna, Gianenrico, additional, Spadaro, Giuseppe, additional, Vaghi, Adriano, additional, Gans, Steven, additional, Hölters, Jurgen, additional, Langeveld, B., additional, Pieters, Willem, additional, Staaks, G.H.A., additional, van Veen, Ilonka, additional, van den Berg, J.W.K., additional, Einvik, Gunnar, additional, Lehmann, Sverre, additional, Ali García, Ismael, additional, Almonacid, Carlos, additional, Bobolea, Irina, additional, Campo Mozo, Paloma, additional, de Luiz, Gustavo, additional, Domingo Ribas, Christian, additional, Echave-Sustaeta María-Tomé, José María, additional, García Rivero, Juan Luis, additional, García-Cosío Piqueras, Borja, additional, Gómez-Bastero Fernández, Ana, additional, González Pérez, Ruperto, additional, Henríquez Santa, Aythamy, additional, Martínez Rivera, Carlos, additional, Muñoz Gall, Xavier, additional, Ramos, Jacinto, additional, Gregorio Soto Campos, Jose, additional, Vidal Pan, Carmen, additional, Stenfors, Nikolai, additional, Tunsäter, Alf, additional, Vinge, Ines, additional, Chaudhuri, Rekha, additional, Harrison, Timothy, additional, Mansur, Adel, additional, Nasser, Shuaib, additional, Nordstrom, Monica, additional, Pfeffer, Paul, additional, Saralaya, Dinesh, additional, Short, Philip, additional, Adlakha, Arun, additional, Alpan, Oral, additional, Averill, Francis, additional, Badhwar, Anil, additional, Bardelas, Jose, additional, Baxter, Barbara, additional, Bensch, George, additional, Berger, William, additional, Bernstein, Jonathan, additional, Bridges, Tracy, additional, Brimeyer, Ryan, additional, Calhoun, William, additional, Campbell, Edward, additional, Cherry, William Brett, additional, Chupp, Geoffrey, additional, Clore, Lee, additional, Cohn, John, additional, Cole, Jeremy, additional, Condemi, John, additional, Cury, James, additional, Davis, Benjamin, additional, DeLeon, Samuel, additional, Delacruz, Luis, additional, Diaz, Joseph, additional, Erb, David, additional, Eziri, Emeka, additional, Fakih, Faisal, additional, Fiedler, Douglas, additional, Fost, David, additional, Fritz, Stephen, additional, Gonzalez, Erika, additional, Goodman, Brad, additional, Gottlieb, Peter, additional, Gottschlich, Gregory, additional, Gower, Richard, additional, Hajal, Rizan, additional, Harris, James, additional, Heidarian-Raissy, Hengameh, additional, Heyder, Albrecht, additional, Hill, David, additional, Holguin, Fernando, additional, Hussain, Iftikhar, additional, Illowite, Jonathan, additional, Jacobs, Joshua, additional, Jarratt, Mikell, additional, Kaiser, Harold, additional, Kao, Neil, additional, Kashyap, Ravindra, additional, Kaufman, David, additional, Kent, Edward, additional, Kim, Kenneth, additional, Klein, Ryan, additional, Kraft, Monica, additional, Kono, Ritsu, additional, Kureishy, Shahrukh, additional, Leflein, Jeffrey, additional, Leong, Mila, additional, Li, Huamin, additional, Lin, Robert, additional, Lugogo, Njira, additional, Marcus, Michael, additional, Maselli Caceres, Diego Jose, additional, Mehta, Vinay, additional, Mello, Curtis, additional, Millard, Mark, additional, Milstone, Aaron, additional, Moore, Wendy, additional, Moss, Mark, additional, Mumneh, Nayla, additional, O'Brien, Thomas, additional, Ostransky, David, additional, Palumbo, Michael, additional, Parikh, Purvi, additional, Parikh, Sudhir, additional, Patel, Amit, additional, Perez, Guido, additional, Pleskow, Warren, additional, Prenner, Bruce, additional, Puppala, Dileep, additional, Ramey, John, additional, Reibman, Joan, additional, Reyes, Ramon, additional, Robinette, Emory, additional, Rodicio, Ileana, additional, Ryan, Stephen, additional, Sekhsaria, Sudhir, additional, Sigal, Barry, additional, Sikand, Vinay, additional, Soong, Weily, additional, Spangenthal, Selwyn, additional, St. John, Roy, additional, Steven, Gary, additional, Subramaniam, Vijay, additional, Sumino, Kaharu, additional, Sztejman, Eric, additional, Tan, Ricardo A., additional, Tanus, Tonny, additional, Thompson, Charles, additional, Thornblade, Carl, additional, Villareal, Manuel, additional, Wenzel, Sally, additional, Zafra, Heidi, additional, and Ziedalski, Tomasz, additional

Published
2021
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37. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Bagnasco, Diego, primary, Povero, Massimiliano, additional, Pradelli, Lorenzo, additional, Brussino, Luisa, additional, Rolla, Giovanni, additional, Caminati, Marco, additional, Menzella, Francesco, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Paggiaro, Pierluigi, additional, Senna, Gianenrico, additional, Milanese, Manlio, additional, Lombardi, Carlo, additional, Bucca, Caterina, additional, Manfredi, Andrea, additional, Canevari, Rikki Frank, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Latorre, Manuela, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Colombo, Gisella, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, Blasi, Francesco, additional, D'Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D'Amato, additional, Verrillo, Maria Vittoria, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Aletti, Eleonora, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D'Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
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38. Beclomethasone rapidly ablates allergen-induced [[beta].sub.2]-adrenoceptor pathway dysfunction in human isolated bronchi

Author

Brichetto, Lorenzo, Milanese, Manlio, Song, Pingfang, Patrone, Mauro, Crimi, Emanuele, Rehder, Kai, and Brusasco, Vito

Subjects
Asthma -- Care and treatment, Beclomethasone dipropionate -- Health aspects, Biological sciences
Abstract

Bronchial rings from nonatopic humans were passively sensitized with serum from allergic subjects. Allergen challenge significantly reduced the relaxant effect of salbutamol on carbachol-induced contractions, suggesting [[beta].sub.2]-adrenoceptor ([[beta].sub.2]-AR) pathway dysfunction. Incubation of challenged rings for 3 h with 3 x [10.sup.-6] M beclomethasone dipropionate (BDP) restored the relaxant effect, suggesting reversal of [[beta].sub.2]-AR pathway dysfunction. Incubation with the [G.sub.s][alpha] protein-stimulating cholera toxin attenuated contractile responses to carbachol significantly less in challenged than in unchallenged rings. Treatment of challenged rings with BDP resulted in an inhibitory effect of cholera toxin that was similar to the effect in unchallenged rings. [G.sub.s][alpha] protein expression was not significantly altered by BDP, suggesting that the activity of [G.sub.s][alpha] protein was increased. Relaxation of challenged rings by forskolin was not significantly affected by BDP, suggesting that [[beta].sub.2]-AR pathway dysfunction was proximal to the adenylyl cyclase. In conclusion, short-term (3-h) treatment with BDP after allergen challenge ablated [[beta].sub.]-AR pathway dysfunction by increasing the activity of the [G.sub.s][alpha] protein in human isolated bronchi. asthma; cholera toxin; corticosteroids; [G.sub.s][alpha] protein; passive sensitization

Published
2003

39. Higher blood eosinophil levels after omalizumab treatment may be associated with poorer asthma outcomes

Author

Sposato, B., Migliorini, M.G., Di Tomassi, M., Olivieri, C., Perrella, A., Camiciottoli, G., Maselli, R., Pelaia, G., Busceti, M.T., Sabato, E., Cagnazzo, M.G., Colombo, F., Palumbo, L., Ravazzi, A., Bucca, C., Caiaffa, M.F., Berra, A., Calabrese, C., Stanziola, A.A., Schino, P., Di Gioacchino, M., Rogliani, P., Cazzola, M., Segreti, A., Pastorello, E.A., Scibilia, G., Vianello, A., Marchi, M.R., Paladini, L., Baglioni, S., Abbritti, M., Almerigogna, F., Matucci, A., Vultaggio, A., Maggi, E., Maestrelli, P., Guarnieri, G., Steinhilber, G., Bonavia, M., Rottoli, P., Bargagli, E., Senna, G., Caminati, M., Macchia, L., Bellia, V., Scichilone, N., Paggiaro, P., Novelli, F., Latorre, M., Vergura, L., Masieri, S., Scalese, M., Rosati, Y., Milanese, M., Folletti, I., Pio, R., Pio, A., Maccari, U., Maggiorelli, C., Scala, R., Vignale, L., Pulerà, N., Carpagnano, G.E., Foschino Barbaro, M.P., Sposato, Bruno, Scalese, Marco, Milanese, Manlio, Masieri, Simonetta, Cavaliere, Carlo, Latorre, Manuela, Scichilone, Nicola, Ricci, Alberto, Cresti, Alberto, Santus, Pierachille, Olivieri, Carmela, Perrella, Antonio, Rogliani, Paola, and Paggiaro, Pierluigi

Published
2019
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41. A prevalent exposure to male dog is a risk factor for exclusive allergic sensitization to Can f 5: An Italian multicenter study

Author

Liccardi, Gennaro, primary, Calzetta, Luigino, additional, Bilò, Maria Beatrice, additional, Brusca, Ignazio, additional, Cecchi, Lorenzo, additional, Costantino, Maria Teresa, additional, Da Re, Mirella, additional, Buzzulini, Francesca, additional, Giani, Mauro, additional, Lombardi, Carlo, additional, Meneguzzi, Giorgia, additional, Meriggi, Antonio, additional, Milanese, Manlio, additional, Onida, Rosa, additional, Patella, Vincenzo, additional, Pignatti, Patrizia, additional, Quercia, Oliviero, additional, Ridolo, Erminia, additional, Sabatino, Giusy, additional, Sacerdoti, Carlo, additional, Savi, Eleonora, additional, Scala, Enrico, additional, Steinhilber, Gundi, additional, Villalta, Danilo, additional, Passalacqua, Giovanni, additional, Rogliani, Paola, additional, Baiardini, Ilaria, additional, Baldo, Ermanno, additional, Bucca, Caterina, additional, Canonica, Giorgio Walter, additional, Heffler, Enrico, additional, La Grutta, Stefania, additional, Rolla, Giovanni, additional, Rossi, Oliviero, additional, Senna, Gianenrico, additional, Sposato, Bruno, additional, Tesi, Carlo Filippo, additional, and Viegi, Giovanni, additional

Published
2020
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42. Minimal clinically important difference for asthma endpoints: an expert consensus report

Author

Bonini, Matteo, primary, Di Paolo, Marcello, additional, Bagnasco, Diego, additional, Baiardini, Ilaria, additional, Braido, Fulvio, additional, Caminati, Marco, additional, Carpagnano, Elisiana, additional, Contoli, Marco, additional, Corsico, Angelo, additional, Del Giacco, Stefano, additional, Heffler, Enrico, additional, Lombardi, Carlo, additional, Menichini, Ilaria, additional, Milanese, Manlio, additional, Scichilone, Nicola, additional, Senna, Gianenrico, additional, and Canonica, Giorgio W., additional

Published
2020
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44. The importance of being not significant: Blood eosinophils and clinical responses do not correlate in severe asthma patients treated with mepolizumab in real life

Author

Bagnasco, Diego, primary, Massolo, Alessandro, additional, Bonavia, Marco, additional, Brussino, Luisa, additional, Bucca, Caterina, additional, Caminati, Marco, additional, Canonica, Giorgio Walter, additional, Caruso, Cristiano, additional, D’Amato, Maria, additional, De Ferrari, Laura, additional, Guida, Giuseppe, additional, Heffler, Enrico, additional, Lombardi, Carlo, additional, Menzella, Francesco, additional, Milanese, Manlio, additional, Paoletti, Giovanni, additional, Riccio, Anna Maria, additional, Rolla, Giovanni, additional, Senna, Gianenrico, additional, Testino, Elisa, additional, and Passalacqua, Giovanni, additional

Published
2020
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46. ARIA (Allergic Rhinitis and its Impact on Asthma) 2019. Percorsi di cura per la rinite allergica -ITALIA

Author

Passalacqua, Giovanni, Cecchi, Lorenzo, Canonica, Giorgio Walter, Lombardi, Carlo, Ventura, Maria Teresa, Bachert, Claus, Wystke J Fokkens, Tari Haahtela, Klimek, Ludger, Berlin Berlin, Arasi, Stefania, Bagnasco, Diego, Baiardini, Ilaria, Bernardini, Roberto, Bilò, Maria Beatrice, Bonini, Sergio, G Walter Canonica, Canevari, Rikki F, Caviglia, Antonio, Enrico 39 Compalati, Cottini, Marcello, Mariangiola Crivellaro, Duse, Marzia, Fiocchi, Alessandro, Folletti, Gelardi, Matteo, Heffler, Enrico, Incorvaia, Cristoforo, Infantino, Antonio, Leo, Gualtiero, Maggi, Enrico, Marseglia, Gianluigi, Melioli, Giovanni, Milanese, Manlio, Musarra, Antonino, Nettis, Eustachio, Pajno, Giovanni, Pala, Gianni, Peroni, Diego, Ridolo, Rolla, Giovanni, Rossi, Oliviero, Savi, Eleonora, Senna, Gianenrico, Tesi, Filippo, Triggiani, Massimo, Uberti, Marzio, Zedda, Maria Teresa, and Landi, Massimo

Published
2019
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50. Face masks during COVID-19 pandemic lockdown and selfreported seasonal allergic rhinitis symptoms.

Author

Liccardi, Gennaro, Bilò, Maria Beatrice, Milanese, Manlio, Martini, Matteo, Calzetta, Luigino, Califano, Francesco, Carucci, Laura, Ciccarelli, Anna, Cutajar, Marina, D'Auria, Paolo, De Bartolomeis, Fabio, Iacono, Iride Dello, Franzese, Antonio, Gargano, Domenico, Inciso, Gianni, Giordano, AnnaClaudia, Iannaccone, Riccardo, Lo Schiavo, Mario, Nappi, Liliana, and Madonna, Francesco

Published
2021
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