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Lung function and peak oxygen uptake in chronic obstructive pulmonary disease phenotypes with and without emphysema
- Source :
- Rasch-Halvorsen, Ø, Hassel, E, Brumpton, B M, Jenssen, H, Spruit, M A, Langhammer, A & Steinshamn, S 2021, ' Lung function and peak oxygen uptake in chronic obstructive pulmonary disease phenotypes with and without emphysema ', PLoS ONE, vol. 16, no. 5, e0252386 . https://doi.org/10.1371/journal.pone.0252386, PLoS ONE, PLOS ONE, PLOS ONE, 16(5):e0252386. Public Library of Science, PLoS ONE, Vol 16, Iss 5, p e0252386 (2021)
- Publication Year :
- 2021
-
Abstract
- Previous studies of associations of forced expiratory lung volume in one second (FEV1) with peak oxygen uptake (VO2peak) in chronic obstructive pulmonary disease (COPD) have not taken sex, age and height related variance of dynamic lung volumes into account. Nor have such demographic spread of spirometric measures been considered in studies comparing VO2peak between COPD phenotypes characterized by degree of emphysema. We aimed to assess the association of FEV1Z-score with VO2peak in COPD (n = 186) and investigate whether this association differs between emphysema (E-COPD) and non-emphysema (NE-COPD) phenotypes. Corresponding assessments using standardized percent predicted FEV1 (ppFEV1) were performed for comparison. Additionally, phenotype related differences in VO2peak were compared using FEV1Z-score and ppFEV1 as alternative expressions of FEV1. E-COPD and NE-COPD were defined by transfer factor of the lung for carbon monoxide below and above lower limits of normal (LLN), respectively. The associations were assessed in linear regression models. One unit reduction in FEV1Z-score was associated with 1.9 (95% CI 1.4, 2.5) ml/kg/min lower VO2peak. In stratified analyses, corresponding estimates were 2.2 (95% CI 1.4, 2.9) and 1.2 (95% CI 0.2, 2.2) ml/kg/min lower VO2peak in E-COPD and NE-COPD, respectively. The association did not differ statistically by COPD phenotype (p-value for interaction = 0.153). Similar estimates were obtained in analyses using standardized ppFEV1. Compared to NE-COPD, VO2peak was 2.2 (95% CI 0.8, 3.6) and 2.1 (95% CI 0.8, 3.5) ml/kg/min lower in E-COPD when adjusted for FEV1Z-score and ppFEV1, respectively. In COPD, FEV1Z-score is positively associated with VO2peak. This association was stronger in E-COPD but did not differ statistically by phenotype. Both the association of FEV1 with VO2peak and the difference in VO2peak comparing COPD phenotypes seems independent of sex, age and height related variance in FEV1. Mechanisms leading to reduction in FEV1 may contribute to lower VO2peak in E-COPD.
- Subjects :
- Male
Pulmonology
Pulmonary Function
DYNAMIC HYPERINFLATION
Gastroenterology
EXERCISE CAPACITY
Pulmonary function testing
Medical Conditions
FLOW LIMITATION
Medicine and Health Sciences
Medicine
Lung volumes
Public and Occupational Health
Community Health Services
Dynamic hyperinflation
Health Education
Lung
COPD
Multidisciplinary
medicine.diagnostic_test
Pharmaceutics
VO2 max
Drugs
Middle Aged
Sports Science
Chemistry
medicine.anatomical_structure
Pulmonary Emphysema
Hypertension
Physical Sciences
Female
Research Article
Chemical Elements
Adult
Spirometry
medicine.medical_specialty
Beta-Adrenergic Antagonist Therapy
Science
Chronic Obstructive Pulmonary Disease
INTOLERANCE
DIAGNOSIS
Respiratory Disorders
Bronchodilators
Drug Therapy
Internal medicine
Linear regression
Humans
Sports and Exercise Medicine
Exercise
Aged
Sweden
Emphysema
Pharmacology
business.industry
MORTALITY
Biology and Life Sciences
Physical Activity
medicine.disease
SPIROMETRY
respiratory tract diseases
VENTILATION
Oxygen
Dyspnea
Physical Fitness
VOLUME
Patient Compliance
business
human activities
Receptor Antagonist Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- Rasch-Halvorsen, Ø, Hassel, E, Brumpton, B M, Jenssen, H, Spruit, M A, Langhammer, A & Steinshamn, S 2021, ' Lung function and peak oxygen uptake in chronic obstructive pulmonary disease phenotypes with and without emphysema ', PLoS ONE, vol. 16, no. 5, e0252386 . https://doi.org/10.1371/journal.pone.0252386, PLoS ONE, PLOS ONE, PLOS ONE, 16(5):e0252386. Public Library of Science, PLoS ONE, Vol 16, Iss 5, p e0252386 (2021)
- Accession number :
- edsair.doi.dedup.....2e51a5f69a786d7aa4dccea52f20c320