Search

Your search keyword '"Miki, Hisanori"' showing total 44 results
Start Over Author "Miki, Hisanori"
44 results on '"Miki, Hisanori"'

7. Prognostic scoring system based on indicators reflecting the tumor glandular differentiation and microenvironment for patients with colorectal cancer

Author

Kobayashi, Toshinori, primary, Ishida, Mitsuaki, additional, Miki, Hisanori, additional, Yamamoto, Nobuyuki, additional, Harino, Takashi, additional, Yagyu, Takuki, additional, Hori, Soshi, additional, Hatta, Masahiko, additional, Hashimoto, Yuki, additional, Kotsuka, Masaya, additional, Yamasaki, Makoto, additional, Inoue, Kentaro, additional, Hirose, Yoshinobu, additional, and Sekimoto, Mitsugu, additional

Published
2024
Full Text
View/download PDF

9. Laparoscopic polyglycolic acid spacer placement for locally recurrent rectal cancer.

Author

Kobayashi, Toshinori, Sekimoto, Mitsugu, Miki, Hisanori, Yamamoto, Nobuyuki, Harino, Takashi, Yagyu, Takuki, Hori, Soshi, Hatta, Masahiko, Hashimoto, Yuki, Kotsuka, Masaya, Yamasaki, Makoto, and Inoue, Kentaro

Subjects
RECTAL cancer, BIOABSORBABLE implants, LAPAROSCOPIC surgery, TECHNICAL reports, OPERATIVE surgery, ACIDS
Abstract

Carbon ion radiotherapy (CIRT) has received attention for the treatment of locally recurrent rectal cancer. When the surrounding primary organs are close to the irradiation site, a spacer is required to ensure safe irradiation. This work describes a novel technique using a bioabsorbable polyglycolic acid spacer placed laparoscopically and presents a technical report with five case studies. The short‐term surgical outcomes were as follows: mean operating time 235 min with blood loss of 38 mL. CIRT was planned, and the patients underwent irradiation within 2 months of surgery. No pelvic infections occurred, and all procedures were performed safely. Herein, were present a technical report with reference to a video of the surgical procedure. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Single‐incision laparoscopic surgery for benign peritoneal cystic mesothelioma—A Video Vignette.

Author

Kobayashi, Toshinori, Miyazaki, Hidetaka, Yagyu, Takuki, Hatta, Masahiko, Miki, Hisanori, and Sekimoto, Mitsugu

Subjects
LAPAROSCOPIC surgery, MESOTHELIOMA, VIGNETTES, PLASTIC surgery
Abstract

This article discusses a case of a 29-year-old woman who presented with lower abdominal distention and was found to have a benign peritoneal cystic mesothelioma (BPCM). The patient underwent single-incision laparoscopic surgery (SILS) through a Pfannenstiel incision in the lower abdomen. The surgery was successful, with minimal blood loss and a good postoperative course. This case report is the first of its kind to describe the resection of BPCM using SILS. The article includes histopathological and immunohistochemical features of the BPCM and provides information about the authors' contributions, funding, conflict of interest, data availability, ethics statement, and consent to participate. [Extracted from the article]

Published
2024
Full Text
View/download PDF

16. Surgeons' fear of getting infected by COVID19: A global survey

Author

An, Yongbo, primary, Bellato, Vittoria, additional, Konishi, Tsuyoshi, additional, Pellino, Gianluca, additional, Sensi, Bruno, additional, Siragusa, Leandro, additional, Franceschilli, Marzia, additional, Sica, Giuseppe S, additional, Kefleyesus, A, additional, Hoofwijk, A G M, additional, Eldaly, Abdullah Sami, additional, Gonzalez, Abel, additional, Jawad, Adraoui, additional, Jooma, Ahmad, additional, Hafez, Ahmed Mousa, additional, Rubio, Ainhoa Valle, additional, Landaluce-Olavarria, Aitor, additional, Wu, Aiwen, additional, Nagatsu, Akihisa, additional, Inoue, Akira, additional, Kanamoto, Akira, additional, Ouchi, Akira, additional, El-Hussuna, Alaa, additional, Vazquez-Melero, Alba, additional, Wolthuis, Albert M, additional, Peral, Alberto M, additional, Lozano, Alejandra Cruz, additional, Efremov, Aleksandr, additional, Ryasantsev, Aleksandr V, additional, Di Giorgio, Alessandra, additional, Parente, Alessandro, additional, Tamburrini, Alessandro, additional, Alò, Alessio, additional, Forero-Torres, Alexander, additional, Vahrmeijer, Alexander L, additional, Varabei, Alexander, additional, Hinojosa, Siles, additional, Balkan, Ali Zeynel Abidin, additional, Frontali, Alice, additional, Oleg, Alikin, additional, Soler-Silva, Álvaro, additional, Makni, Amin, additional, André, Ana, additional, Cabrera, Ana María García, additional, Fernández, Ana María Gonzalez, additional, Minaya-Bravo, Ana M, additional, Rodríguez-Sánchez, Ana, additional, Musina, Ana-Maria, additional, Pangeni, Anang, additional, Zolotko, Anastasia, additional, Tonoyan, Andranik, additional, Balla, Andrea, additional, Belli, Andrea, additional, Cavallaro, Andrea, additional, Chierici, Andrea, additional, Divizia, Andrea, additional, Bucci, Andrea Fares, additional, Salido, Andrea Jiménez, additional, Morini, Andrea, additional, Muratore, Andrea, additional, Vignali, Andrea, additional, Chitul, Andrei, additional, Sebastian, Diaconescu Andrei, additional, Pcolkins, Andrejs, additional, Shchegolev, Andrey, additional, Hollenbeck, Andrew, additional, Wisneski, Andrew, additional, Iossa, Angelo, additional, D'Amore, Anna, additional, Hunter, Anndrew, additional, Hesketh, Anthony J, additional, La Brocca, Andrea, additional, Spinelli, Antonino, additional, Caires, Antonio, additional, D'Alessandro, Antonio, additional, Correo, Antonio Francisco Sanchís López, additional, Macrì, Antonio, additional, Navarro-Sánchez, Antonio, additional, Pronk, Apollo, additional, Akunc, Aram, additional, Mehri, Arash, additional, Pelta, Arie, additional, Papadopoulos, Aristeidis, additional, Kechagias, Aristotelis, additional, Rashid, Arshad, additional, Ramazanov, Artur, additional, Chandio, Ashfaq, additional, Kohyama, Atsushi, additional, Nishimura, Atsushi, additional, Ohkawa, Atsushi, additional, Dulskas, Audrius, additional, Jamal, Aun, additional, Mariani, Aurora, additional, Unal, Ayse Gizem, additional, Karagoz, Ayse, additional, Ozkan, Bahar Busra, additional, Salih, Barham, additional, Gülcü, Baris, additional, Pessia, Beatrice, additional, Martin-Perez, Beatriz, additional, Ielpo, Benedetto, additional, Tulelli, Berenice, additional, Yang, Bin, additional, Mhamed, Boumadani, additional, Murphy, Brenda, additional, Pirozzi, Brunella Maria, additional, Langenhoff, Bs, additional, Belevi, Bulent, additional, Güney, Burak, additional, Ng, Caecilia, additional, Rueda, Camilo, additional, Roxburgh, Campbell S, additional, Feo, Carlo V, additional, Ferrari, Carlo, additional, Gazia, Carlo, additional, Pratesi, Carlo, additional, Ratto, Carlo, additional, Santacruz, Carlos Cerdán, additional, Arroyave, Carlos Rodolfo Martinez, additional, Macias, Carlos, additional, Fernandez, Carlota Garcia, additional, Fernandez, Carmen Cagigas, additional, Curtis-Martinez, Carolina, additional, Fortmann, Caroline, additional, Kim, Caroline, additional, Galeano, Catalina Uribe, additional, Barroso, Catarina, additional, Baldi, Caterina, additional, Foppa, Caterina, additional, Formisano, Cesare, additional, Li, Changzai, additional, Ding, Chao, additional, Wang, Chenyu, additional, Iacusso, Chiara, additional, Yang, Chongwei, additional, Pizzera, Christian, additional, Skias, Christoph, additional, Chouliras, Christos, additional, Liakos, Christos, additional, Matsuda, Chu, additional, Wu, Chun-yi, additional, Ozaslan, Cihangir, additional, Tanda, Cinzia, additional, Tommaso, Cipolat Mis, additional, Dagorno, Claire, additional, Ramos, Claudia Patricia Arellano, additional, Arcudi, Claudio, additional, Coco, Claudio, additional, Morales, Cleotilde Mateo, additional, Ali, Mujahid Zulfiqar, additional, Lozano, Coral Cózar, additional, Sala, Corrado, additional, Leo, Cosimo Alex, additional, Scarpa, Cosimo Riccardo, additional, Ferro, Cristian Varela, additional, Fernandez, Cristina Mosquera, additional, Morales-Garcia, D, additional, Nakano, Daisuke, additional, Cristian, Daniel, additional, Hechtl, Daniel, additional, Cánovas, Daniel Triguero, additional, Calabrese, Daniela, additional, Rega, Daniela, additional, Ferraro, Daniele, additional, Morezzi, Daniele, additional, Sommacale, Daniele, additional, Brogden, Danielle, additional, Miskovic, Danilo, additional, Merlini, David, additional, Pertile, Davide, additional, Coniglio, Denise, additional, Zhu, Dexiang, additional, Wu, Dianwen, additional, Coletta, Diego, additional, Rubio, Diego Ramos, additional, Sasia, Diego, additional, Fillipov, Dmitry, additional, Russiello, Domenico, additional, Dardanov, Dragomir, additional, Consten, E C J, additional, Smolskas, Edgaras, additional, Muttillo, Edoardo Maria, additional, Jones, Edward, additional, Sunami, Eiji, additional, Etienne, El-Helou, additional, Chalkiadaki, Elena, additional, Giacomelli, Elena, additional, Karbovnichaya, Elena, additional, Ruiz-Úcar, Elena, additional, Guaitoli, Eleonora, additional, Samadov, Elgun, additional, Jovine, Elio, additional, Treppiedi, Elio, additional, Vaterlini, Elisa Maria, additional, Zambaiti, Elisa, additional, Moggia, Elisabetta, additional, Coetzee, Elmi, additional, Chisari, Emanuele, additional, D'Errico, Emanuele, additional, Ciofic, Emilia, additional, Peña, Emilio, additional, Kurt, Emine, additional, Balık, Emre, additional, Gunay, Emre, additional, Sivrikoz, Emre, additional, Andolfi, Enrico, additional, Araimo, Enrico, additional, Lucci, Enrico, additional, Opocher, Enrico, additional, Pinotti, Enrico, additional, Rubino, Enrico, additional, Reyhan, Enver, additional, Mazzotta, Erica, additional, Navarro, Ernesto Barzola, additional, El-Helou, Etienne, additional, Licardie-Bolaños, Eugenio, additional, Porto, Eva Iglesias, additional, Contreras, Evelyn, additional, Boerma, Evert-Jan, additional, Cianchi, Fabio, additional, Marino, Fabio, additional, Uggeri, Fabio, additional, Han, Fanghai, additional, Calculli, Federica, additional, Falaschi, Federica, additional, Ghignone, Federico, additional, Perrone, Federico, additional, Borghi, Felice, additional, García, Felipe, additional, Agresta, Ferdinando, additional, Cananzi, Ferdinando Carlo Maria, additional, Mendoza-Moreno, Fernando, additional, Cengiz, Fevzi, additional, Almeida, Filipe Macedo, additional, Baracchi, Filippo, additional, Carannante, Filippo, additional, La Torre, Filippo, additional, Fernandes, Flavio, additional, Friedmacher, Florian, additional, Grama, Florin, additional, Carissimi, Francesca, additional, Pecchini, Francesca, additional, Bianco, Francesco, additional, Colombo, Francesco, additional, Ferrara, Francesco, additional, Litta, Francesco, additional, Carrano, Francesco Maria, additional, Martignoni, Francesco, additional, Tasselli, Francesco Menegon, additional, Milone, Francesco, additional, Pata, Francesco, additional, Sammartino, Francesco, additional, Zambianchi, Francesco, additional, Barragan, Francisco, additional, Herrero, Francisco, additional, Schlottmann, Francisco, additional, Den Boer, Frank C, additional, Pfeffer, Frank, additional, Fujita, Fumihiko, additional, Navarra, G, additional, Herrera-Almario, Gabriel, additional, Pozzo, Gabriele, additional, Capolupo, Gabriella Teresa, additional, Van Ramshorst, Gabrielle H, additional, Liscia, Gadiel, additional, Gallo, Gaetano, additional, Asawa, Ganesh, additional, Wang, Gaoxiang, additional, Raiyani, Gaurang, additional, Beets, Geerard, additional, Naval, Gemma Sugrañes, additional, Jin, Genfeng, additional, Chang, George J, additional, Saakian, George, additional, Kahane, Gerardo, additional, Borroni, Giacomo, additional, Lo Secco, Giacomo, additional, Baiocchi, Gian Luca, additional, Baronio, Gianluca, additional, Pagano, Gianluca, additional, Pattacini, Gianmaria Casoni, additional, Lisi, Giorgio, additional, Milito, Giovanni, additional, Sinibaldi, Giovanni, additional, Serrao, Giuditta, additional, Bagaglini, Giulia, additional, Sarro, Giuliano, additional, Brisinda, Giuseppe, additional, Candilio, Giuseppe, additional, Mangiameli, Giuseppe, additional, Giuliani, Giuseppe, additional, Martin-Martin, Gonzalo Pablo, additional, Bodzin, Gordon, additional, Leon, Graat, additional, Mackay, Graham, additional, Vasil, Granila, additional, Palmisano, Graziano, additional, Giovanna, Grella Maria, additional, Fernández, Guadalupe Campos, additional, Steingel, Guillermo Berrones, additional, Zhang, Guoyun, additional, Choi, Gyu Seog, additional, Chen, Haipeng, additional, Hirose, Hajime, additional, Kayano, Hajime, additional, Ulgur, Hanife Seyda, additional, Impellizzeri, Harmony, additional, Ariola, Hasani, additional, Liu, Heli, additional, Medina, Heriberto, additional, Miyauchi, Hideaki, additional, Takahashi, Hidekazu, additional, Hayashi, Hideki, additional, Ishikawa, Hideki, additional, Ishida, Hideyuki, additional, De Vries, Hilbert, additional, Ulman, Hilmican, additional, Kon, Hirofumi, additional, Ota, Hirofumi, additional, Akamatsu, Hiroki, additional, Tamagawa, Hiroshi, additional, Shoji, Hirotaka, additional, Egi, Hiroyuki, additional, Matsubara, Hisahiro, additional, Miki, Hisanori, additional, Elfeki, Hossam, additional, Lin, Hung-Hsin, additional, Giani, Iacopo, additional, Caravaca-García, Iban, additional, Takemasa, Ichiro, additional, Angriman, Imerio, additional, Negoi, Ionut, additional, Volkova, Irina, additional, Russo, Iris, additional, Kronberger, Irmgard E, additional, Shageev, Iskander, additional, Aydin, Ishak, additional, Mora Guzmán, Ismael, additional, Novak, Ivana, additional, Giuliano, Izzo, additional, Rachmuth, Jacob, additional, Ngu, James Chi-Yong, additional, Glasbey, James, additional, Stoot, Jan, additional, Žatecky, Jan, additional, Melenhorst, Jarno, additional, Van Der Wal, J B C, additional, Leijtens, Jeroen, additional, Bogach, Jessica, additional, Elliott, Jessie, additional, De Wilt, J H W, additional, Han, Jiagang, additional, Cui, Jian, additional, Liu, Jiaqi, additional, Khan, Jim, additional, Wirawan, Jimmy Panji, additional, Zhang, Jinji, additional, Manyari, Joel Davis Osorio, additional, Doerner, Johannes, additional, Bock, Jonathan, additional, Konsten, Joop, additional, Castro, Jorge Mario, additional, Grobas, Jorge Pérez, additional, Pereira, José, additional, Juloski, Jovan, additional, Laina, Juan Luis Blas, additional, Solórzano, Juan José, additional, López, Juan Ramón Gómez, additional, Li, Jun, additional, Watanabe, Jun, additional, Kwak, Jung-Myun, additional, Hasegawa, Junichi, additional, Hiro, Junichiro, additional, Sergey, K, additional, Zhang, Kai, additional, Nagahori, Kaoru, additional, Martinez, Karla, additional, Tokuhara, Katsuji, additional, Danno, Katsuki, additional, Uehara, Kay, additional, Yoshimatsu, Kazuhiko, additional, Ehara, Kazuhisa, additional, Ueda, Kazuki, additional, Suda, Kazuyoshi, additional, Yamamoto, Kazuyuki, additional, Ishimaru, Kei, additional, Kimura, Kei, additional, Hirata, Keiji, additional, Deen, Kemal, additional, Imaizumi, Ken, additional, Yamada, Jenji, additional, Tanakura, Kenta, additional, Rida, Khaled, additional, Sugimoto, Kiichi, additional, Kotaro, Kitani, additional, Shi, Kiwisure, additional, Okabayashi, Koji, additional, Hida, Koya, additional, Kataoka, Kozo, additional, Hongo, Kumiko, additional, Xia, Kunkun, additional, Tseng, Larissa, additional, Reime, Lars, additional, Lorenzon, Laura, additional, Ruano, Laura Muiños, additional, Zhou, Lei, additional, De Nes, Lindsey, additional, Brandariz, Lorena, additional, Morini, Lorenzo, additional, Petagna, Lorenzo, additional, Ripamonti, Lorenzo, additional, Martinez, Lourdes Hernandez, additional, Pio, Luca, additional, Sacco, Luca, additional, Carvalho, Lucia, additional, Zorcolo, Luigi, additional, Pérez-Sánchez, Luis Eduardo, additional, Esparza, Luis Humberto Reyes, additional, Aguilar, Luis Tallon, additional, Garner, Madeleine, additional, Sugimoto, Maki, additional, Nagashima, Makoto, additional, Shiozawa, Manabu, additional, Simone, Manfredelli, additional, Ferrer-Marquez, Manuel, additional, Carvalho, Marcia, additional, Alifano, Marco, additional, Arganini, Marco, additional, Calussi, Marco, additional, Catarci, Marco, additional, Allaix, Marco Ettore, additional, Forlin, Marco, additional, Milone, Marco, additional, Paci, Marco, additional, Fodor, Margot, additional, Antipova, Maria, additional, Martos, Maria Beltran, additional, Giuffrida, Maria Carmela, additional, Tabernilla, María Diez, additional, Quirós, María José Alcaide, additional, Lemma, Maria, additional, Correo, Maria Luisa Reyes Diaz, additional, Małowiecka, Maria, additional, Bellomo, Maria Paola, additional, Fernandez, Maria Ramos, additional, Socias, María, additional, Rizk, Mariam, additional, Aurora, Mariani, additional, Antolinez, Mariano Alvarez, additional, Ninkovic, Marijana, additional, Giuffrida, Mario, additional, De Roos, Marnix A J, additional, Lara, Marta Cañón, additional, Agustin, Marta Climent, additional, Cuadrado, Marta, additional, Pascual, Marta, additional, Lemmerer, Martina, additional, Carlos, R, additional, Okamoto, Masa, additional, Miyo, Masaaki, additional, Inomata, Masafumi, additional, Ikenaga, Masakazu, additional, Tsujie, Masaki, additional, Yasuno, Masamichi, additional, Kotake, Masanori, additional, Sato, Masanori, additional, Yasui, Masayoshi, additional, Lavazza, Matteo, additional, Rottoli, Matteo, additional, Zuin, Matteo, additional, Zuluaga, Mauricio, additional, Cervellera, Maurizio, additional, Cesari, Maurizio, additional, Zizzo, Maurizio, additional, Garino, Mauro, additional, Ghirardi, Mauro, additional, Montuori, Mauro, additional, Podda, Mauro, additional, Santarelli, Mauro, additional, Koc, Mehmet Ali, additional, Baini, Melissa, additional, Campanelli, Michela, additional, Manigrasso, Michele, additional, Zuolo, Michele, additional, Cunha, Miguel F, additional, Misca, Mihaela, additional, Slavchev, Mihail, additional, Danilov, Mikhail, additional, Shigaev, Mikhail, additional, Martens, Milou, additional, Kobayashi, Minako, additional, Ren, Mingyang, additional, Ishizuka, Mitsuru, additional, Hassan, Mohammed Mustafa, additional, Siblini, Mohamad, additional, Sahloul, Mohamed, additional, Keramati, Mohammad Reza, additional, Karunakaran, Monish, additional, Markel, Moritz, additional, Majeed, Mudassar, additional, Younis, Muhammad Umar, additional, Akin, Muhammed Ikbal, additional, Laraibe, Munazza, additional, Derebey, Murat, additional, Kendirci, Murat, additional, Fukunaga, Mutsumi, additional, Matsubara, Nagahide, additional, Ordaz, Narce Eunice Cruz, additional, Samalavicius, Narimantas Evaldas, additional, Keeratibharat, Nattawut, additional, Angelis, Nicola, additional, Gica, Nicolae, additional, Mariani, Nicoló Maria, additional, Ramino, Nicolò, additional, Falco, Nicolò, additional, Smart, Neil, additional, De Korte, Niels, additional, Kok, Niels F M, additional, Jamieson, Nigel B, additional, Aberyasev, Nikolay, additional, Bruklich, Nikolay, additional, Ichikawa, Nobuki, additional, Miyoshi, Norikatsu, additional, De Palma, Norma, additional, Figueiredo, Nuno, additional, Torrecilla, Nuria Ortega, additional, Dybov, Oleg G, additional, Yudin, Oleg, additional, Crepin, Ollende, additional, Gomez, Oscar, additional, Sert, Ozlem Zeliha, additional, Lominchar, Pablo Lozano, additional, Menéndez, Pablo, additional, De Nardi, Paola, additional, Tejedor, Patricia, additional, Jordan, Patrick, additional, Tan, Patrick, additional, Marsanic, Patrizia, additional, Natalya, Pechnikova, additional, Baños, Pedro Parra, additional, Rebasa, Pere, additional, Neary, Peter M, additional, Tanis, Pieter, additional, Giustacchini, Piero, additional, Anoldo, Pietro, additional, Concejo, Pilar, additional, Cao, Pin, additional, Chandrasinghe, Pramodh, additional, Abeyratne, Prasad, additional, Wang, Quan, additional, Klicks, R J, additional, Riquelme, Rafael Ferrer, additional, De Luca, Raffaele, additional, Galli, Raffaele, additional, Gianesini, Raffaele, additional, Moorjani, Rajesh Gianchandani, additional, Deshpande, Rajkiran K, additional, Gorter, Ramon, additional, Ledesma, Raquel Leon, additional, Ruslan, Rategov, additional, Chhabra, Raunaq, additional, Talreja-Pelaez, Reena, additional, Suzuki, Rei, additional, Balestri, Riccardo, additional, Rosati, Riccardo, additional, Kiblawi, Rim, additional, Martins, Rita, additional, Angelico, Roberta, additional, Tutino, Roberta, additional, Persiani, Roberto, additional, Pollastri, Roberto, additional, López, Rocío González, additional, Perez, Rodrigo Oliva, additional, Hompes, Roel, additional, Lukanin, Roman, additional, Roser Termes Serra, R, additional, Brunaccino, Rossella, additional, Nakanishi, Ryota, additional, Stefan, Samuel, additional, Hernández, Sandra Paola Sánchez, additional, Di Carlo, Sara, additional, Ingallinella, Sara, additional, Domoto, Satoru, additional, Ikeda, Satoshi, additional, Mikalauskas, Saulius, additional, Kim, Seon Hahn, additional, Mantova, Serena, additional, Barbuta, Severius, additional, Li, Shaotang, additional, Yamaguchi, Shigeki, additional, Yamagishi, Shigeru, additional, Homma, Shigenori, additional, Tsujinaka, Shingo, additional, Yoshioka, Shinichi, additional, Mori, Shinichiro, additional, Tewari, Shirish, additional, Rayman, Shlomi, additional, Horiuchi, Sho, additional, Matoba, Shuichiro, additional, Morita, Shunji, additional, Yaman, Sibel, additional, Vigna, Silvia, additional, Testa, Silvio, additional, Ng, Simon, additional, Deidda, Simona, additional, Cicconi, Simone, additional, Di Maria, Simone, additional, Sibio, Simone, additional, Ersoz, Siyar, additional, Pejkova, Sofija, additional, Altarifi, Soliman, additional, He, Songbing, additional, Malakorn, Songphol, additional, Meindert, Sosef, additional, Sumikawa, Sosuke, additional, Parmar, Stavan, additional, Uranitsch, Stefan, additional, D'ugo, Stefano, additional, Giuliani, Stefano, additional, Breukink, Stéphanie, additional, Lee, Suk-Hwan, additional, Hata, Taishi, additional, Ishikawa, Takahisa, additional, Akiyoshi, Takashi, additional, Azuma, Takashi, additional, Kobatake, Takaya, additional, Fukuzaki, Takayuki, additional, Aiyama, Takeshi, additional, Yamada, Takeshi, additional, Garmanova, Tatiana, additional, Gómez-Sánchez, Tatiana, additional, Yamaguchi, Tatsuro, additional, Flores, Teresa De Jesús, additional, Usub, Teruyuki, additional, Tsuruma, Tetsuhiro, additional, Shimizu, Tetsuichiro, additional, Hristov, Tihomir Georgiev, additional, Van Loon, Ting, additional, Funakoshi, Tohru, additional, Manzia, Tommaso Maria, additional, Kiyomatsu, Tomomichi, additional, Katayama, Tomonari, additional, Kazuhito, Uemura, additional, Elmore, Ugo, additional, Grossi, Ugo, additional, Truchalev, Vadim A, additional, Rodríguez, Valentina Sosa, additional, Testa, Valentina, additional, Tonini, Valeria, additional, Celentano, Valerio, additional, Bettencourt, Vanessa, additional, Mammadov, Vasif, additional, Leyva, Verónica Alejandra Galue, additional, Mariscal, Veronica Georgina Ortega, additional, Seid, Victor Edmond, additional, Klemann, Victor, additional, Turrado-Rodriguez, Víctor, additional, Papagni, Vincenzo, additional, Vento, Vincenzo, additional, Frering, Vincent, additional, Vigorita, Vincenzo, additional, Petrove, Vitaliva V, additional, Lyadov, Vladimir, additional, Fu, Wei, additional, Mi, Wei, additional, Jeong, Woon Kyung, additional, Leclercq, Wouter K G, additional, De Sousa, Xavier, additional, Zhao, Xing, additional, Li, Xinxiang, additional, Wang, Xinxin, additional, Yang, Xuanhua, additional, Zhang, Xuelei, additional, Dong, Yan, additional, Erushevich, Yana, additional, Takii, Yasumasa, additional, Sumi, Yasuo, additional, Loli, Yeray Trujillo, additional, Yifat, Yosef Lishtzinsky, additional, Shimada, Yoshifumi, additional, Nabeya, Yoshihiro, additional, Ide, Yoshihito, additional, Wu, Yuan, additional, Tsukada, Yuichiro, additional, Miyamoto, Yuji, additional, Toiyama, Yuji, additional, Fujie, Yujiro, additional, Kaneko, Yuka, additional, Mokutani, Yukako, additional, Fujii, Yuki, additional, Kanemitsu, Yukihide, additional, Medkova, Yulia, additional, Chen, Yulong, additional, Ruiz, Yurema Gonzalez, additional, Kinugasa, Yusuke, additional, Sow, Zacaria, additional, Razzaq, Zeeshan, additional, Wang, Zejun, additional, Liu, Zheng, additional, Han, Zhenguo, additional, Tai, Zhihui, additional, Lai, Zhiyong, additional, Ng, Zi Qin, additional, and Dambrauskas, Zilvinas, additional

Published
2020
Full Text
View/download PDF

17. Impact of asymptomatic COVID-19 patients in global surgical practice during the COVID-19 pandemic

Author

Bellato, V, primary, Konishi, T, additional, Pellino, G, additional, An, Y, additional, Piciocchi, A, additional, Sensi, B, additional, Siragusa, L, additional, Khanna, K, additional, Pirozzi, B M, additional, Franceschilli, M, additional, Campanelli, M, additional, Efetov, S, additional, Sica, G S, additional, Kefleyesus, A, additional, Hoofwijk, A G M, additional, Eldaly, Abdullah Sami, additional, Gonzalez, Abel, additional, Jawad, Adraoui, additional, Jooma, Ahmad, additional, Hafez, Ahmed Mousa, additional, Rubio, Ainhoa Valle, additional, Landaluce-Olavarria, Aitor, additional, Wu, Aiwen, additional, Nagatsu, Akihisa, additional, Inoue, Akira, additional, Kanamoto, Akira, additional, Ouchi, Akira, additional, El-Hussuna, Alaa, additional, Vazquez-Melero, Alba, additional, Wolthuis, Albert M, additional, Peral, Alberto M, additional, Lozano, Alejandra Cruz, additional, Efremov, Aleksandr, additional, Ryasantsev, Aleksandr V, additional, Di Giorgio, Alessandra, additional, Parente, Alessandro, additional, Tamburrini, Alessandro, additional, Alò, Alessio, additional, Forero-Torres, Alexander, additional, Vahrmeijer, Alexander L, additional, Varabei, Alexander, additional, Hinojosa, Siles, additional, Balkan, Ali Zeynel Abidin, additional, Frontali, Alice, additional, Oleg, Alikin, additional, Soler-Silva, Álvaro, additional, Makni, Amin, additional, André, Ana, additional, Cabrera, Ana María García, additional, Fernández, Ana María Gonzalez, additional, Minaya-Bravo, Ana M, additional, Rodríguez-Sánchez, Ana, additional, Musina, Ana-Maria, additional, Pangeni, Anang, additional, Zolotko, Anastasia, additional, Tonoyan, Andranik, additional, Balla, Andrea, additional, Belli, Andrea, additional, Cavallaro, Andrea, additional, Chierici, Andrea, additional, Divizia, Andrea, additional, Bucci, Andrea Fares, additional, Salido, Andrea Jiménez, additional, Morini, Andrea, additional, Muratore, Andrea, additional, Vignali, Andrea, additional, Chitul, Andrei, additional, Sebastian, Diaconescu Andrei, additional, Pcolkins, Andrejs, additional, Shchegolev, Andrey, additional, Hollenbeck, Andrew, additional, Wisneski, Andrew, additional, Iossa, Angelo, additional, D'Amore, Anna, additional, Hunter, Anndrew, additional, Hesketh, Anthony J, additional, La Brocca, Andrea, additional, Spinelli, Antonino, additional, Caires, Antonio, additional, D'Alessandro, Antonio, additional, Correo, Antonio Francisco Sanchís López, additional, Macrì, Antonio, additional, Navarro-Sánchez, Antonio, additional, Pronk, Apollo, additional, Akunc, Aram, additional, Mehri, Arash, additional, Pelta, Arie, additional, Papadopoulos, Aristeidis, additional, Kechagias, Aristotelis, additional, Rashid, Arshad, additional, Ramazanov, Artur, additional, Chandio, Ashfaq, additional, Kohyama, Atsushi, additional, Nishimura, Atsushi, additional, Ohkawa, Atsushi, additional, Dulskas, Audrius, additional, Jamal, Aun, additional, Mariani, Aurora, additional, Unal, Ayse Gizem, additional, Karagoz, Ayse, additional, Ozkan, Bahar Busra, additional, Salih, Barham, additional, Gülcü, Baris, additional, Pessia, Beatrice, additional, Martin-Perez, Beatriz, additional, Ielpo, Benedetto, additional, Tulelli, Berenice, additional, Yang, Bin, additional, Mhamed, Boumadani, additional, Murphy, Brenda, additional, Pirozzi, Brunella Maria, additional, Sensi, Bruno, additional, Langenhoff, Bs, additional, Belevi, Bulent, additional, Güney, Burak, additional, Ng, Caecilia, additional, Rueda, Camilo, additional, Roxburgh, Campbell S, additional, Feo, Carlo V, additional, Ferrari, Carlo, additional, Gazia, Carlo, additional, Pratesi, Carlo, additional, Ratto, Carlo, additional, Santacruz, Carlos Cerdán, additional, Arroyave, Carlos Rodolfo Martinez, additional, Macias, Carlos, additional, Fernandez, Carlota Garcia, additional, Fernandez, Carmen Cagigas, additional, Curtis-Martinez, Carolina, additional, Fortmann, Caroline, additional, Kim, Caroline, additional, Galeano, Catalina Uribe, additional, Barroso, Catarina, additional, Baldi, Caterina, additional, Foppa, Caterina, additional, Formisano, Cesare, additional, Li, Changzai, additional, Ding, Chao, additional, Wang, Chenyu, additional, Iacusso, Chiara, additional, Yang, Chongwei, additional, Pizzera, Christian, additional, Skias, Christoph, additional, Chouliras, Christos, additional, Liakos, Christos, additional, Matsuda, Chu, additional, Wu, Chun-yi, additional, Ozaslan, Cihangir, additional, Tanda, Cinzia, additional, Tommaso, Cipolat Mis, additional, Dagorno, Claire, additional, Ramos, Claudia Patricia Arellano, additional, Arcudi, Claudio, additional, Coco, Claudio, additional, Morales, Cleotilde Mateo, additional, Ali, Mujahid Zulfiqar, additional, Lozano, Coral Cózar, additional, Sala, Corrado, additional, Leo, Cosimo Alex, additional, Scarpa, Cosimo Riccardo, additional, Ferro, Cristian Varela, additional, Fernandez, Cristina Mosquera, additional, Morales-Garcia, D, additional, Nakano, Daisuke, additional, Cristian, Daniel, additional, Hechtl, Daniel, additional, Cánovas, Daniel Triguero, additional, Calabrese, Daniela, additional, Rega, Daniela, additional, Ferraro, Daniele, additional, Morezzi, Daniele, additional, Sommacale, Daniele, additional, Brogden, Danielle, additional, Miskovic, Danilo, additional, Merlini, David, additional, Pertile, Davide, additional, Coniglio, Denise, additional, Zhu, Dexiang, additional, Wu, Dianwen, additional, Coletta, Diego, additional, Rubio, Diego Ramos, additional, Sasia, Diego, additional, Fillipov, Dmitry, additional, Russiello, Domenico, additional, Dardanov, Dragomir, additional, Consten, E C J, additional, Smolskas, Edgaras, additional, Muttillo, Edoardo Maria, additional, Jones, Edward, additional, Sunami, Eiji, additional, Etienne, El-Helou, additional, Chalkiadaki, Elena, additional, Giacomelli, Elena, additional, Karbovnichaya, Elena, additional, Ruiz-Úcar, Elena, additional, Guaitoli, Eleonora, additional, Samadov, Elgun, additional, Jovine, Elio, additional, Treppiedi, Elio, additional, Vaterlini, Elisa Maria, additional, Zambaiti, Elisa, additional, Moggia, Elisabetta, additional, Coetzee, Elmi, additional, Chisari, Emanuele, additional, D'Errico, Emanuele, additional, Ciofic, Emilia, additional, Peña, Emilio, additional, Kurt, Emine, additional, Balık, Emre, additional, Gunay, Emre, additional, Sivrikoz, Emre, additional, Andolfi, Enrico, additional, Araimo, Enrico, additional, Lucci, Enrico, additional, Opocher, Enrico, additional, Pinotti, Enrico, additional, Rubino, Enrico, additional, Reyhan, Enver, additional, Mazzotta, Erica, additional, Navarro, Ernesto Barzola, additional, El-Helou, Etienne, additional, Licardie-Bolaños, Eugenio, additional, Porto, Eva Iglesias, additional, Contreras, Evelyn, additional, Boerma, Evert-Jan, additional, Cianchi, Fabio, additional, Marino, Fabio, additional, Uggeri, Fabio, additional, Han, Fanghai, additional, Calculli, Federica, additional, Falaschi, Federica, additional, Ghignone, Federico, additional, Perrone, Federico, additional, Borghi, Felice, additional, García, Felipe, additional, Agresta, Ferdinando, additional, Cananzi, Ferdinando Carlo Maria, additional, Mendoza-Moreno, Fernando, additional, Cengiz, Fevzi, additional, Almeida, Filipe Macedo, additional, Baracchi, Filippo, additional, Carannante, Filippo, additional, La Torre, Filippo, additional, Fernandes, Flavio, additional, Friedmacher, Florian, additional, Grama, Florin, additional, Carissimi, Francesca, additional, Pecchini, Francesca, additional, Bianco, Francesco, additional, Colombo, Francesco, additional, Ferrara, Francesco, additional, Litta, Francesco, additional, Carrano, Francesco Maria, additional, Martignoni, Francesco, additional, Tasselli, Francesco Menegon, additional, Milone, Francesco, additional, Pata, Francesco, additional, Sammartino, Francesco, additional, Zambianchi, Francesco, additional, Barragan, Francisco, additional, Herrero, Francisco, additional, Schlottmann, Francisco, additional, Den Boer, Frank C, additional, Pfeffer, Frank, additional, Fujita, Fumihiko, additional, Navarra, G, additional, Herrera-Almario, Gabriel, additional, Pozzo, Gabriele, additional, Capolupo, Gabriella Teresa, additional, Van Ramshorst, Gabrielle H, additional, Liscia, Gadiel, additional, Gallo, Gaetano, additional, Asawa, Ganesh, additional, Wang, Gaoxiang, additional, Raiyani, Gaurang, additional, Beets, Geerard, additional, Naval, Gemma Sugrañes, additional, Jin, Genfeng, additional, Chang, George J, additional, Saakian, George, additional, Kahane, Gerardo, additional, Borroni, Giacomo, additional, Lo Secco, Giacomo, additional, Baiocchi, Gian Luca, additional, Baronio, Gianluca, additional, Pagano, Gianluca, additional, Pattacini, Gianmaria Casoni, additional, Lisi, Giorgio, additional, Milito, Giovanni, additional, Sinibaldi, Giovanni, additional, Serrao, Giuditta, additional, Bagaglini, Giulia, additional, Sarro, Giuliano, additional, Brisinda, Giuseppe, additional, Candilio, Giuseppe, additional, Mangiameli, Giuseppe, additional, Giuliani, Giuseppe, additional, Martin-Martin, Gonzalo Pablo, additional, Bodzin, Gordon, additional, Leon, Graat, additional, Mackay, Graham, additional, Vasil, Granila, additional, Palmisano, Graziano, additional, Giovanna, Grella Maria, additional, Fernández, Guadalupe Campos, additional, Steingel, Guillermo Berrones, additional, Zhang, Guoyun, additional, Choi, Gyu Seog, additional, Chen, Haipeng, additional, Hirose, Hajime, additional, Kayano, Hajime, additional, Ulgur, Hanife Seyda, additional, Impellizzeri, Harmony, additional, Ariola, Hasani, additional, Liu, Heli, additional, Medina, Heriberto, additional, Miyauchi, Hideaki, additional, Takahashi, Hidekazu, additional, Hayashi, Hideki, additional, Ishikawa, Hideki, additional, Ishida, Hideyuki, additional, De Vries, Hilbert, additional, Ulman, Hilmican, additional, Kon, Hirofumi, additional, Ota, Hirofumi, additional, Akamatsu, Hiroki, additional, Tamagawa, Hiroshi, additional, Shoji, Hirotaka, additional, Egi, Hiroyuki, additional, Matsubara, Hisahiro, additional, Miki, Hisanori, additional, Elfeki, Hossam, additional, Lin, Hung-Hsin, additional, Giani, Iacopo, additional, Caravaca-García, Iban, additional, Takemasa, Ichiro, additional, Angriman, Imerio, additional, Negoi, Ionut, additional, Volkova, Irina, additional, Russo, Iris, additional, Kronberger, Irmgard E, additional, Shageev, Iskander, additional, Aydin, Ishak, additional, Mora Guzmán, Ismael, additional, Novak, Ivana, additional, Giuliano, Izzo, additional, Rachmuth, Jacob, additional, Ngu, James Chi-Yong, additional, Glasbey, James, additional, Stoot, Jan, additional, Žatecky, Jan, additional, Melenhorst, Jarno, additional, Van Der Wal, J B C, additional, Leijtens, Jeroen, additional, Bogach, Jessica, additional, Elliott, Jessie, additional, De Wilt, J H W, additional, Han, Jiagang, additional, Cui, Jian, additional, Liu, Jiaqi, additional, Khan, Jim, additional, Wirawan, Jimmy Panji, additional, Zhang, Jinji, additional, Manyari, Joel Davis Osorio, additional, Doerner, Johannes, additional, Bock, Jonathan, additional, Konsten, Joop, additional, Castro, Jorge Mario, additional, Grobas, Jorge Pérez, additional, Pereira, José, additional, Juloski, Jovan, additional, Laina, Juan Luis Blas, additional, Solórzano, Juan José, additional, López, Juan Ramón Gómez, additional, Li, Jun, additional, Watanabe, Jun, additional, Kwak, Jung-Myun, additional, Hasegawa, Junichi, additional, Hiro, Junichiro, additional, Sergey, K, additional, Zhang, Kai, additional, Nagahori, Kaoru, additional, Martinez, Karla, additional, Tokuhara, Katsuji, additional, Danno, Katsuki, additional, Uehara, Kay, additional, Yoshimatsu, Kazuhiko, additional, Ehara, Kazuhisa, additional, Ueda, Kazuki, additional, Suda, Kazuyoshi, additional, Yamamoto, Kazuyuki, additional, Ishimaru, Kei, additional, Kimura, Kei, additional, Hirata, Keiji, additional, Deen, Kemal, additional, Imaizumi, Ken, additional, Yamada, Jenji, additional, Tanakura, Kenta, additional, Rida, Khaled, additional, Sugimoto, Kiichi, additional, Kotaro, Kitani, additional, Shi, Kiwisure, additional, Okabayashi, Koji, additional, Hida, Koya, additional, Kataoka, Kozo, additional, Hongo, Kumiko, additional, Xia, Kunkun, additional, Tseng, Larissa, additional, Reime, Lars, additional, Lorenzon, Laura, additional, Ruano, Laura Muiños, additional, Siragusa, Leandro, additional, Zhou, Lei, additional, De Nes, Lindsey, additional, Brandariz, Lorena, additional, Morini, Lorenzo, additional, Petagna, Lorenzo, additional, Ripamonti, Lorenzo, additional, Martinez, Lourdes Hernandez, additional, Pio, Luca, additional, Sacco, Luca, additional, Carvalho, Lucia, additional, Zorcolo, Luigi, additional, Pérez-Sánchez, Luis Eduardo, additional, Esparza, Luis Humberto Reyes, additional, Aguilar, Luis Tallon, additional, Garner, Madeleine, additional, Sugimoto, Maki, additional, Nagashima, Makoto, additional, Shiozawa, Manabu, additional, Simone, Manfredelli, additional, Ferrer-Marquez, Manuel, additional, Carvalho, Marcia, additional, Alifano, Marco, additional, Arganini, Marco, additional, Calussi, Marco, additional, Catarci, Marco, additional, Allaix, Marco Ettore, additional, Forlin, Marco, additional, Milone, Marco, additional, Paci, Marco, additional, Franceschilli, Marzia, additional, Fodor, Margot, additional, Antipova, Maria, additional, Martos, Maria Beltran, additional, Giuffrida, Maria Carmela, additional, Tabernilla, María Diez, additional, Quirós, María José Alcaide, additional, Lemma, Maria, additional, Correo, Maria Luisa Reyes Diaz, additional, Małowiecka, Maria, additional, Bellomo, Maria Paola, additional, Fernandez, Maria Ramos, additional, Socias, María, additional, Rizk, Mariam, additional, Aurora, Mariani, additional, Antolinez, Mariano Alvarez, additional, Ninkovic, Marijana, additional, Giuffrida, Mario, additional, De Roos, Marnix A J, additional, Lara, Marta Cañón, additional, Agustin, Marta Climent, additional, Cuadrado, Marta, additional, Pascual, Marta, additional, Lemmerer, Martina, additional, Carlos, R, additional, Okamoto, Masa, additional, Miyo, Masaaki, additional, Inomata, Masafumi, additional, Ikenaga, Masakazu, additional, Tsujie, Masaki, additional, Yasuno, Masamichi, additional, Kotake, Masanori, additional, Sato, Masanori, additional, Yasui, Masayoshi, additional, Lavazza, Matteo, additional, Rottoli, Matteo, additional, Zuin, Matteo, additional, Zuluaga, Mauricio, additional, Cervellera, Maurizio, additional, Cesari, Maurizio, additional, Zizzo, Maurizio, additional, Garino, Mauro, additional, Ghirardi, Mauro, additional, Montuori, Mauro, additional, Podda, Mauro, additional, Santarelli, Mauro, additional, Koc, Mehmet Ali, additional, Baini, Melissa, additional, Campanelli, Michela, additional, Manigrasso, Michele, additional, Zuolo, Michele, additional, Cunha, Miguel F, additional, Misca, Mihaela, additional, Slavchev, Mihail, additional, Danilov, Mikhail, additional, Shigaev, Mikhail, additional, Martens, Milou, additional, Kobayashi, Minako, additional, Ren, Mingyang, additional, Ishizuka, Mitsuru, additional, Hassan, Mohammed Mustafa, additional, Siblini, Mohamad, additional, Sahloul, Mohamed, additional, Keramati, Mohammad Reza, additional, Karunakaran, Monish, additional, Markel, Moritz, additional, Majeed, Mudassar, additional, Younis, Muhammad Umar, additional, Akin, Muhammed Ikbal, additional, Laraibe, Munazza, additional, Derebey, Murat, additional, Kendirci, Murat, additional, Fukunaga, Mutsumi, additional, Matsubara, Nagahide, additional, Ordaz, Narce Eunice Cruz, additional, Samalavicius, Narimantas Evaldas, additional, Keeratibharat, Nattawut, additional, Angelis, Nicola, additional, Gica, Nicolae, additional, Mariani, Nicoló Maria, additional, Ramino, Nicolò, additional, Falco, Nicolò, additional, Smart, Neil, additional, De Korte, Niels, additional, Kok, Niels F M, additional, Jamieson, Nigel B, additional, Aberyasev, Nikolay, additional, Bruklich, Nikolay, additional, Ichikawa, Nobuki, additional, Miyoshi, Norikatsu, additional, De Palma, Norma, additional, Figueiredo, Nuno, additional, Torrecilla, Nuria Ortega, additional, Dybov, Oleg G, additional, Yudin, Oleg, additional, Crepin, Ollende, additional, Gomez, Oscar, additional, Sert, Ozlem Zeliha, additional, Lominchar, Pablo Lozano, additional, Menéndez, Pablo, additional, De Nardi, Paola, additional, Tejedor, Patricia, additional, Jordan, Patrick, additional, Tan, Patrick, additional, Marsanic, Patrizia, additional, Natalya, Pechnikova, additional, Baños, Pedro Parra, additional, Rebasa, Pere, additional, Neary, Peter M, additional, Tanis, Pieter, additional, Giustacchini, Piero, additional, Anoldo, Pietro, additional, Concejo, Pilar, additional, Cao, Pin, additional, Chandrasinghe, Pramodh, additional, Abeyratne, Prasad, additional, Wang, Quan, additional, Klicks, R J, additional, Riquelme, Rafael Ferrer, additional, De Luca, Raffaele, additional, Galli, Raffaele, additional, Gianesini, Raffaele, additional, Moorjani, Rajesh Gianchandani, additional, Deshpande, Rajkiran K, additional, Gorter, Ramon, additional, Ledesma, Raquel Leon, additional, Ruslan, Rategov, additional, Chhabra, Raunaq, additional, Talreja-Pelaez, Reena, additional, Suzuki, Rei, additional, Balestri, Riccardo, additional, Rosati, Riccardo, additional, Kiblawi, Rim, additional, Martins, Rita, additional, Angelico, Roberta, additional, Tutino, Roberta, additional, Persiani, Roberto, additional, Pollastri, Roberto, additional, López, Rocío González, additional, Perez, Rodrigo Oliva, additional, Hompes, Roel, additional, Lukanin, Roman, additional, Roser Termes Serra, R, additional, Brunaccino, Rossella, additional, Nakanishi, Ryota, additional, Stefan, Samuel, additional, Hernández, Sandra Paola Sánchez, additional, Di Carlo, Sara, additional, Ingallinella, Sara, additional, Domoto, Satoru, additional, Ikeda, Satoshi, additional, Mikalauskas, Saulius, additional, Kim, Seon Hahn, additional, Mantova, Serena, additional, Barbuta, Severius, additional, Li, Shaotang, additional, Yamaguchi, Shigeki, additional, Yamagishi, Shigeru, additional, Homma, Shigenori, additional, Tsujinaka, Shingo, additional, Yoshioka, Shinichi, additional, Mori, Shinichiro, additional, Tewari, Shirish, additional, Rayman, Shlomi, additional, Horiuchi, Sho, additional, Matoba, Shuichiro, additional, Morita, Shunji, additional, Yaman, Sibel, additional, Vigna, Silvia, additional, Testa, Silvio, additional, Ng, Simon, additional, Deidda, Simona, additional, Cicconi, Simone, additional, Di Maria, Simone, additional, Sibio, Simone, additional, Ersoz, Siyar, additional, Pejkova, Sofija, additional, Altarifi, Soliman, additional, He, Songbing, additional, Malakorn, Songphol, additional, Meindert, Sosef, additional, Sumikawa, Sosuke, additional, Parmar, Stavan, additional, Uranitsch, Stefan, additional, D'ugo, Stefano, additional, Giuliani, Stefano, additional, Breukink, Stéphanie, additional, Lee, Suk-Hwan, additional, Hata, Taishi, additional, Ishikawa, Takahisa, additional, Akiyoshi, Takashi, additional, Azuma, Takashi, additional, Kobatake, Takaya, additional, Fukuzaki, Takayuki, additional, Aiyama, Takeshi, additional, Yamada, Takeshi, additional, Garmanova, Tatiana, additional, Gómez-Sánchez, Tatiana, additional, Yamaguchi, Tatsuro, additional, Flores, Teresa De Jesús, additional, Usub, Teruyuki, additional, Tsuruma, Tetsuhiro, additional, Shimizu, Tetsuichiro, additional, Hristov, Tihomir Georgiev, additional, Van Loon, Ting, additional, Funakoshi, Tohru, additional, Manzia, Tommaso Maria, additional, Kiyomatsu, Tomomichi, additional, Katayama, Tomonari, additional, Kazuhito, Uemura, additional, Elmore, Ugo, additional, Grossi, Ugo, additional, Truchalev, Vadim A, additional, Rodríguez, Valentina Sosa, additional, Testa, Valentina, additional, Tonini, Valeria, additional, Celentano, Valerio, additional, Bettencourt, Vanessa, additional, Mammadov, Vasif, additional, Leyva, Verónica Alejandra Galue, additional, Mariscal, Veronica Georgina Ortega, additional, Seid, Victor Edmond, additional, Klemann, Victor, additional, Turrado-Rodriguez, Víctor, additional, Papagni, Vincenzo, additional, Vento, Vincenzo, additional, Frering, Vincent, additional, Vigorita, Vincenzo, additional, Petrove, Vitaliva V, additional, Lyadov, Vladimir, additional, Fu, Wei, additional, Mi, Wei, additional, Jeong, Woon Kyung, additional, Leclercq, Wouter K G, additional, De Sousa, Xavier, additional, Zhao, Xing, additional, Li, Xinxiang, additional, Wang, Xinxin, additional, Yang, Xuanhua, additional, Zhang, Xuelei, additional, Dong, Yan, additional, Erushevich, Yana, additional, Takii, Yasumasa, additional, Sumi, Yasuo, additional, Loli, Yeray Trujillo, additional, Yifat, Yosef Lishtzinsky, additional, Shimada, Yoshifumi, additional, Nabeya, Yoshihiro, additional, Ide, Yoshihito, additional, Wu, Yuan, additional, Tsukada, Yuichiro, additional, Miyamoto, Yuji, additional, Toiyama, Yuji, additional, Fujie, Yujiro, additional, Kaneko, Yuka, additional, Mokutani, Yukako, additional, Fujii, Yuki, additional, Kanemitsu, Yukihide, additional, Medkova, Yulia, additional, Chen, Yulong, additional, Ruiz, Yurema Gonzalez, additional, Kinugasa, Yusuke, additional, Sow, Zacaria, additional, Razzaq, Zeeshan, additional, Wang, Zejun, additional, Liu, Zheng, additional, Han, Zhenguo, additional, Tai, Zhihui, additional, Lai, Zhiyong, additional, Ng, Zi Qin, additional, and Dambrauskas, Zilvinas, additional

Published
2020
Full Text
View/download PDF

18. Two cases of primary solitary fibrous tumor in the pelvis resected using laparoscopic surgery

Author

Matsui, Yuki, primary, Hamada, Madoka, additional, Sumiyama, Fusao, additional, Kobayashi, Toshinori, additional, Matsumi, Yuki, additional, Miki, Hisanori, additional, Ishida, Mitsuaki, additional, Kurokawa, Hiroaki, additional, Sekimoto, Mitsugu, additional, Sekita-Hatakeyama, Yoko, additional, Hatakeyama, Kinta, additional, and Ohbayashi, Chiho, additional

Published
2020
Full Text
View/download PDF

21. Skeletal muscle loss is an independent negative prognostic factor in patients with advanced lower rectal cancer treated with neoadjuvant chemoradiotherapy

Author

Takeda, Yasuhiro, primary, Akiyoshi, Takashi, additional, Matsueda, Kiyoshi, additional, Fukuoka, Hironori, additional, Ogura, Atsushi, additional, Miki, Hisanori, additional, Hiyoshi, Yukiharu, additional, Nagasaki, Toshiya, additional, Konishi, Tsuyoshi, additional, Fujimoto, Yoshiya, additional, Fukunaga, Yosuke, additional, and Ueno, Masashi, additional

Published
2018
Full Text
View/download PDF

22. N -Ethyl- N -Nitrosourea Induces Retinal Photoreceptor Damage in Adult Rats

Author

Yoshizawa, Katsuhiko, Sasaki, Tomo, Uehara, Norihisa, Kuro, Maki, Kimura, Ayako, Kinoshita, Yuichi, Miki, Hisanori, Yuri, Takashi, and Tsubura, Airo

Subjects
otorhinolaryngologic diseases, retinal degeneration, Original Article, γ-H2A.X, rat, sense organs, photoreceptor cell, PAR, N-ethyl-N-nitrosourea, PARP
Abstract

Seven-week-old male Lewis rats received a single intraperitoneal injection of N-ethyl-N-nitrosourea (ENU) (100, 200, 400 or 600 mg/kg), and retinal damage was evaluated 7 days after the treatment. Sequential morphological features of the retina and retinal DNA damage, as determined by a TUNEL assay and phospho-histone H2A.X (γ-H2AX), were analyzed 3, 6, 12, 24 and 72 hr, 7 days, and/or 30 days after 400 mg/kg ENU treatment. Activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) was analyzed immunohistochemically by poly (ADP-ribose) (PAR) expression in response to DNA damage of the retina. All rats that received ≥ 400 mg/kg of ENU developed retinal degeneration characterized by the loss of photoreceptor cells in both the central and peripheral retina within 7 days. In the 400 mg/kg ENU-treated rats, TUNEL-positive signals were only located in the photoreceptor cells and peaked 24 hr after ENU treatment. The γ-H2AX signals in inner retinal cells appeared at 24 hr and peaked at 72 hr after ENU treatment, and the PAR signals selectively located in the photoreceptor cell nuclei appeared at 12 hr and peaked at 24 hr after ENU treatment. However, degeneration was restricted to photoreceptor cells, and no degenerative changes in inner retinal cells were seen at any time points. Retinal thickness and the photoreceptor cell ratio in the central and peripheral retina were significantly decreased, and the retinal damage ratio was significantly increased 7 days after ENU treatment. In conclusion, ENU induced retinal degeneration in adult rats that was characterized by photoreceptor cell apoptosis through PARP activity.

Published
2012

23. Pretreatment Serum Carbohydrate Antigen 19-9 Concentration Is a Predictor of Survival of Patients Who Have Undergone Curative Resection of Stage IV Rectal Cancer

Author

Miki, Hisanori, primary, Akiyoshi, Takashi, additional, Ogura, Atsushi, additional, Nagasaki, Toshiya, additional, Konishi, Tsuyoshi, additional, Fujimoto, Yoshiya, additional, Nagayama, Satoshi, additional, Noma, Hisashi, additional, Saiura, Akio, additional, Fukunaga, Yosuke, additional, and Ueno, Masashi, additional

Published
2017
Full Text
View/download PDF

24. Report of a Case with Appendiceal Intussusception Induced by Appendiceal Endometriosis

Author

Takeda, Yasuhiro, primary, Nagasaki, Toshiya, additional, Fukuoka, Hironori, additional, Ogura, Atsushi, additional, Miki, Hisanori, additional, Hiyoshi, Yukiharu, additional, Akiyoshi, Takashi, additional, Konishi, Tsuyoshi, additional, Fujimoto, Yoshiya, additional, Nagayama, Satoshi, additional, Fukunaga, Yosuke, additional, and Ueno, Masashi, additional

Published
2017
Full Text
View/download PDF

25. Pathological Complete Response after Preoperative Systemic Chemotherapy and Chemoradiotherapy for Anal Canal Adenocarcinoma with Pagetoid Spread:A Case Report

Author

Fukuoka, Hironori, primary, Nagasaki, Toshiya, additional, Miki, Hisanori, additional, Hiyoshi, Yukiharu, additional, Ogura, Atsushi, additional, Akiyoshi, Takashi, additional, Fujimoto, Yoshiya, additional, Nagayama, Satoshi, additional, Fukunaga, Yosuke, additional, Takamatsu, Manabu, additional, and Ueno, Masashi, additional

Published
2017
Full Text
View/download PDF

27. Pretreatment Serum Carbohydrate Antigen 19-9 Concentration Is a Predictor of Survival of Patients Who Have Undergone Curative Resection of Stage IV Rectal Cancer.

Author

Miki, Hisanori, akiyoshi, Takashi, Ogura, atsushi, Nagasaki, Toshiya, Konishi, Tsuyoshi, Fujimoto, Yoshiya, Nagayama, Satoshi, Noma, Hisashi, Saiura, akio, Fukunaga, Yosuke, and Ueno, Masashi

Subjects
*CARCINOEMBRYONIC antigen, *CA 19-9 test
Abstract

Background: To evaluate whether pretreatment carcinoembryonic antigen and carbohydrate antigen (CA)19-9 are useful predictors of survival in patients with stage IV rectal cancer who have undergone curative resection. Methods: In this retrospective study, data on 73 patients who had undergone curative resection of stage IV rectal cancer were reviewed. Associations between various clinicopathological factors and survival outcomes were analyzed. Results: According to univariate analysis, elevated pretreatment CA19-9 (p = 0.0028), R1 resection (p = 0.0318), and mucinous or poorly differentiated adenocarcinoma (p = 0.0228) were significantly associated with poor overall survival (OS), and lymph node metastasis (p = 0.0211) was significantly associated with poor disease-free survival (DFS). Multivariate analyses showed that elevated pretreatment serum CA19-9 concentration (hazard ratios [HR] 3.33; 95% CI 1.24-9.42; p = 0.0174) was an independent predictor for OS and lymph node metastasis (HR 2.26; 95% CI 1.15-4.82; p = 0.0164) was an independent predictor for DFS. Among 55 patients with recurrences after curative resection, the rate of complete resection of recurrences was significantly higher in patients with normal pretreatment CA19-9 than in those with elevated CA19-9 (p = 0.049). Post-recurrence survival was significantly worse in patients with elevated pretreatment CA19-9 than in those with normal CA19-9 (p = 0.0196). Conclusions: Pretreatment CA19-9 is good predictor of survival after curative resection of stage IV rectal cancer. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

28. Significance of desmoplastic reactions on tumor deposits in patients with colorectal cancer.

Author

Kobayashi, Toshinori, Ishida, Mitsuaki, Miki, Hisanori, Hatta, Masahiko, Hamada, Madoka, Hirose, Yoshinobu, and Sekimoto, Mitsugu

Subjects
COLORECTAL cancer, CANCER patients, LYMPHATIC metastasis, TUMOR budding, PATIENTS, TUMOR microenvironment
Abstract

It has been well recognized that the tumor microenvironment serves important roles in the progression and invasion of cancer. The desmoplastic reaction (DR) is a fibrous tissue reaction around tumor cells, and the prognostic significance of DR in colorectal cancer (CRC) has been established. Tumor deposits (TD) are also an important prognostic indicator of CRC. Notably, immature type DR has been linked to poor prognosis. In addition, immature type DR is significantly associated with a higher pT stage, presence of lymphovascular invasion and lymph node metastasis; however, to the best of our knowledge, the association between DR and TD has not yet been examined. The present study aimed to clarify this association. This study included 443 consecutive patients with pT3 or pT4 CRC who underwent surgical resection. The histopathological features, including DR and TD, were evaluated. Statistical analyses of the presence of TD, DR and other clinicopathological parameters were performed. The present cohort included 205 female and 238 male patients; 293 (66.1%) and 150 (33.9%) patients were classified as pT3 and pT4, respectively. Immature, intermediate and mature DR were noted in 282 (63.7%), 91 (20.5%) and 70 patients (15.8%), respectively. TD was observed in 93 (21.0%) patients. Immature type DR was significantly associated with a higher pT stage (P<0.0001), presence of lymph node metastasis (P<0.0001), lymphatic (P=0.0007), venous (P<0.0001) and perineural invasion (P<0.0001), and higher tumor budding (TB) (P<0.0001). Moreover, immature type DR was significantly associated with the presence of TD (P<0.0001). The present study demonstrated a significant association between immature type DR and the presence of TD, and suggested a close relationship between lymphovascular invasion, DR, TB and TD. Additional studies are required to analyze the detailed mechanism underlying the development of immature DR in CRC to define novel treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2023

37. [Diagnosis of Serous Adenocarcinoma following Pneumatosis Intestinalis Development during Bevacizumab Therapy for Cancer of Unknown Primary-A Case Report].

Author

Morioka S, Kobayashi T, Ishida M, Soejima C, Kita M, Matsui Y, Matsumi Y, Miki H, Hishikawa H, Miki H, Mukaide H, Michiura T, Inoue K, Hamada M, and Sekimoto M

Subjects
Aged, Bevacizumab, Female, Humans, Laparotomy, Adenocarcinoma drug therapy, Adenocarcinoma surgery, Neoplasms, Unknown Primary drug therapy, Pneumatosis Cystoides Intestinalis chemically induced, Pneumatosis Cystoides Intestinalis diagnostic imaging
Abstract

A 75-year-old woman was treated with TC plus Bev for cancer of unknown primary. During treatment, she presented to the clinic with chief complaints of general malaise and anorexia. On presentation, abdominal distention and upper abdominal tenderness were noted, and sepsis was suspected. A thoracoabdominal CT scan revealed prominent intramural emphysema and mesenteric gas in the ascending colon. An emergency laparotomy was performed for suspected pneumatosis intestinalis non-obstructive intestinal ischemia. However, no intra-abdominal contamination or ischemic changes were observed intraoperatively. Histological examination revealed a small adenocarcinoma on the serous surface of the ascending colon, and immunochemical staining confirmed the diagnosis of serous adenocarcinoma as the patient's primary cancer. This report describes a case in which the patient achieved long-term survival after diagnosis. It also emphasizes the importance of identifying the subset of patients with cancer of unknown primary who have a good prognosis in order to provide appropriate treatment.

Published
2021

38. [Asymptomatic longterm survival in a patient with sigmoid colon lymph node metastasis with cancerous ascites of unknown origin].

Author

Miki H, Toyoda M, Senzaki H, Yanagimoto H, Kwon M, and Tsubura A

Subjects
Adenocarcinoma complications, Colon, Sigmoid pathology, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasms, Unknown Primary complications, Time Factors, Adenocarcinoma therapy, Ascites etiology, Neoplasms, Unknown Primary therapy
Abstract

A 63-year-old man bearing a palpable tumor had a lymph node metastasis adjacent to the sigmoid colon that was detected by computed tomography and positron emission tomography. The sigmoid colon and enlarged lymph nodes were surgically resected, and cancerous ascites were present. Pathologically, the tumor in the lymph node was a poorly-differentiated adenocarcinoma that was positive for CA19-9 as well as CK7(-/+), CK20(+/-), VEGF(+), p 53(+)and MIB-1 (>10%). We treated this case as a pancreatic or bile duct carcinoma due to the patient's markedly elevated serum levels of CA19-9 and SPan-1. However, we could not make a conclusive diagnosis. Gemcitabine-based chemotherapy was administered, and the patient had no signs of recurrence for 24 months after the operation. Then, a recurrence was identified by imaging studies, and the chemotherapy was changed to paclitaxel and carboplatin. The patient had stable disease until tumor regrowth was identified 38 months after the operation, chemotherapy was then stopped. However, at 48 months after the operation, the patient remains well and has no symptoms. Our case suggests that surgery and the appropriate choice of anticancer drugs may contribute to the long-term survival of patients with cancer of an unknown primary origin.

Published
2013

39. Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice.

Author

Kanematsu S, Yoshizawa K, Uehara N, Miki H, Sasaki T, Kuro M, Lai YC, Kimura A, Yuri T, and Tsubura A

Subjects
Animals, Antineoplastic Agents therapeutic use, Apoptosis, Body Weight, Breast Neoplasms drug therapy, Cell Line, Tumor, Female, Humans, Isothiocyanates, Ki-67 Antigen metabolism, Lymphatic Metastasis, Mice, Mice, Inbred BALB C, Mice, Nude, Sulfoxides, Thiocyanates therapeutic use, Tumor Burden, Xenograft Model Antitumor Assays, Antineoplastic Agents pharmacology, Breast Neoplasms pathology, Cell Proliferation drug effects, Thiocyanates pharmacology
Abstract

The anticancer effects of sulforaphane (SFN), which is found in cruciferous vegetables, were studied on KPL-1 human breast cancer cells in vitro and in vivo. Cell proliferation in vitro was assessed by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and tumor growth and metastasis in vivo were examined in orthotopically (right thoracic mammary fat pad) transplanted KPL-1 cells in female athymic BALB/c mice. The MTT assay showed that SFN directly inhibited KPL-1 cell growth in vitro (IC50 at 48 h, 19.1 µM; IC50 at 72 h, 17.8 µM). Athymic mice received a KPL-1 cell transplant, and SFN treatment (intraperitoneal injection of 25 or 50 mg/kg SFN) was started the next day. Mice received five injections each week during the 26-day experimental period (for a total of 20 injections). Compared with the SFN-untreated controls, SFN suppressed primary tumor growth. At the termination of the experiment, the final tumor volume was 686±94 mm3 for the control group, 516±70 mm3 (75% of control value) for the 25 mg/kg SFN group and 351±55 mm3 (51% of control value) for the 50 mg/kg SFN group. The final tumor weight was 571±69 mg in the control group, 416±63 mg (73% of the control value) in the 25 mg/kg SFN group and 338±56 mg (59% of the control value) in the 50 mg/kg SFN group. SFN caused a dose-dependent decrease in the proliferation ratio and an increase in the apoptotic ratio of the primary tumor cells. SFN treatment tended to reduce regional (axillary) lymph node metastasis. Treatment with 50 mg/kg SFN significantly inhibited KPL-1 cell growth in vivo by suppressing cell proliferation and inducing apoptosis, and it tended to reduce axillary lymph node metastasis of KPL-1 human breast cancer cell xenografts in female athymic mice.

Published
2011
Full Text
View/download PDF

40. Corneal damage induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea.

Author

Yoshizawa K, Sasaki T, Kuro M, Miki H, Kimura A, Uehara N, Yuri T, and Tsubura A

Subjects
Age Factors, Animals, Cell Proliferation drug effects, Dose-Response Relationship, Drug, Epithelium, Corneal pathology, Female, In Situ Nick-End Labeling, Injections, Intraperitoneal, Mice, Mice, Inbred BALB C, Phosphoproteins metabolism, Proliferating Cell Nuclear Antigen metabolism, Trans-Activators metabolism, Alkylating Agents toxicity, Epithelium, Corneal drug effects, Ethylnitrosourea toxicity
Abstract

Aim: The morphological response and cell kinetics of the mouse cornea to various doses of N-ethyl-N-nitrosourea (ENU) was examined., Materials and Methods: ENU at a dose of 50, 100, 200, 400, or 600 mg/kg was injected intraperitoneally into female BALB/c mice at seven weeks of age. Sequential morphological features and cell kinetics (TUNEL assay as apoptosis marker, PCNA immunostaining as proliferative activity marker, and p63 immunostaining as corneal stem cell marker) of corneal damage caused by 600 mg/kg of ENU were also analyzed 6, 12, 24 and 72 h, and 7 days after exposure. Moreover, older mice (25 to 34 weeks of age) received the same dosage and were sacrificed 7 days later. Both eyes of all mice were analyzed histopathologically and morphometrically, by using the parameters of corneal epithelial thickness., Results: All ENU-treated mice in the 600 mg/kg group developed corneal damage characterized by desquamation and loss of epithelial cells within 7 days. Corneal epithelial thickness was significantly reduced in the 600 mg/kg group as compared to the control group and decreased to approximately half of the normal thickness. Although the number of TUNEL-positive epithelial cells in the ENU-treated mice was similar to that of the control mice, ENU inhibited the proliferative activity of epithelial cells showing PCNA-positivity 72 h after treatment. The p63-positivity of epithelial cells decreased in the central cornea of mice treated with 600 mg/kg of ENU. Older mice did not develop corneal damage from exposure to ENU., Conclusion: ENU induced corneal damage in adult mice, and epithelial cell loss was caused by the inhibition of corneal epithelial proliferation. This is the first report to describe ENU-induced corneal injury in adult mice.

Published
2011

41. Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice.

Author

Kuro M, Yoshizawa K, Uehara N, Miki H, Takahashi K, and Tsubura A

Subjects
Alkylating Agents pharmacology, Animals, Apoptosis drug effects, Cell Death drug effects, Enzyme Activation drug effects, Female, Gene Expression Regulation drug effects, Injections, Intraperitoneal, Mice, Mice, Inbred BALB C, Microtubule-Associated Proteins metabolism, Photoreceptor Cells pathology, Retinal Degeneration chemically induced, Retinal Degeneration pathology, Autophagy drug effects, Calpain antagonists & inhibitors, Carbamates pharmacology, Enzyme Inhibitors pharmacology, Methylnitrosourea pharmacology, Photoreceptor Cells drug effects, Photoreceptor Cells enzymology
Abstract

Aim: A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration involving photoreceptor cell death within 7 days. MNU-induced photoreceptor cell death is due to apoptosis, and is a reliable animal model for human retinitis pigmentosa. The purpose of this study was to elucidate the involvement of calpain-mediated autophagy, as well as apoptosis on the cell death cascade caused by MNU and to evaluate the efficacy of calpain inhibitor SNJ-1945., Materials and Methods: Seven-week-old BALB/c mice were left untreated or received an intraperitoneal (i.p.) injection of MNU. The MNU-exposed mice received an i.p. injection of SNJ-1945 or vehicle alone (distilled water containing 0.5% carboxymethyl cellulose) 3 h prior to MNU and once daily thereafter until sacrifice. Eyes were examined histologically, histochemically, and morphometrically to analyze the photoreceptor cell ratio and retinal damage ratio. The retinal expression of caspase-3, microtubule-associated protein light chain 3 (LC3), autophagy-related protein 5 (Atg5), and α-spectrin was determined by Western blot analysis., Results: During the 72-h period after MNU exposure, the caspase-3 expression increased and the LC3 and Atg5 expression decreased, indicating increased levels of apoptosis and decreased levels of autophagy, as compared with the MNU-unexposed control mouse retina. MNU-induced photoreceptor cell death was caused by increased calpain activation as measured by α-spectrin proteolysis products, while SNJ-1945 ameliorated photoreceptor cell death by blocking calpain activation and restoring basal autophagy., Conclusion: Calpain activation is involved in MNU-induced photoreceptor cell death, and calpain inhibition effectively restored photoreceptor cell autophagy and photoreceptor cell death in mice.

Published
2011

42. Effects of short-term pregnancy hormone treatment against N-methyl-N-nitrosourea-induced mammary carcinomas in female Lewis rats.

Author

Lai YC, Yoshizawa K, Kimura-Kawanaka A, Miki H, Sasaki T, and Tsubura A

Subjects
Animals, Drug Implants, Female, Mammary Neoplasms, Experimental chemically induced, Mammary Neoplasms, Experimental pathology, Methylnitrosourea, Random Allocation, Rats, Rats, Inbred Lew, Time Factors, Treatment Outcome, Tumor Burden drug effects, Estradiol pharmacology, Mammary Neoplasms, Experimental prevention & control, Progesterone pharmacology, Prolactin pharmacology
Abstract

Aim: To study the effects of short-term pregnancy hormone treatment, estradiol and progesterone or prolactin, against pre-existing mammary cancer as well as newly developing mammary cancer by using the N-methyl-N-nitrosourea (MNU)-induced rat mammary cancer model., Materials and Methods: Three-week-old female Lewis rats (n=103) received an intraperitoneal injection of 50 mg/kg MNU. Nine weeks after the MNU injection, the rats received 3 weeks of hormone treatments, consisting of a subcutaneously implanted 0.5 mg estradiol- and 32.5 mg progesterone-containing pellet (E/P group, n=35) or four subcutaneous injections per week of 5 mg/kg perphenazine (PPZ group, n=38), a prolactin-releasing agent. The remaining rats did not receive hormones (control group, n=30). At 12 weeks of age (when the hormone treatments were started), 6 rats in each of the three groups had palpable tumors. These rats were sacrificed at 15 weeks of age, and the remaining rats were sacrificed at 19 weeks of age. The entire mammary glands and the palpable mammary tumors were histologically examined, and the development and growth of mammary tumors was compared., Results: Newly developing mammary tumors were suppressed and pre-existing ones regressed in the E/P group, while the development and growth of both newly developing cancers and pre-existing tumors were accelerated in the PPZ group as compared with the control group., Conclusion: Short-term, pregnancy levels of estradiol and progesterone (but not prolactin) may be the most effective treatment against MNU-induced mammary tumors in female Lewis rats.

Published
2011

43. Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials.

Author

Tsubura A, Lai YC, Miki H, Sasaki T, Uehara N, Yuri T, and Yoshizawa K

Subjects
Alkylating Agents chemistry, Animals, Apoptosis drug effects, Breast Neoplasms pathology, Carcinogens chemistry, Cell Transformation, Neoplastic genetics, Cell Transformation, Neoplastic pathology, Disease Models, Animal, Female, Humans, Methylnitrosourea chemistry, Mutagenesis, Neoplasms, Experimental pathology, Niacinamide therapeutic use, Photoreceptor Cells, Vertebrate drug effects, Retinitis Pigmentosa pathology, Retinitis Pigmentosa therapy, Therapies, Investigational, Alkylating Agents toxicity, Breast Neoplasms chemically induced, Carcinogens toxicity, Cell Transformation, Neoplastic chemically induced, Methylnitrosourea toxicity, Neoplasms, Experimental chemically induced, Retinitis Pigmentosa chemically induced
Abstract

N-Methyl-N-nitrosourea (MNU) is a direct-acting alkylating agent that interacts with DNA. Accumulation of mutations may enhance cancer risk in target organs or cause cell death in susceptible tissues or cells when excessive DNA damage is not repaired. MNU targets various organs in a variety of animal species. MNU-induced carcinogenesis can be used as organ-specific animal models for human cancer, and MNU has been most extensively utilized for the induction of mammary cancer in rats. MNU-induced rat mammary tumors possess many similarities to those of human breast cancer, and the model is utilized for screening cancer modulators. MNU-induced cell disruption is also seen in several organs and tissues, especially when MNU is applied before maturity. However, photoreceptor cells in adults are highly sensitive to MNU, which causes cell death due to apoptosis. MNU-induced photoreceptor apoptosis mimics human retinitis pigmentosa and can be used for studies of therapeutic intervention. In this review, the targets of MNU in various animal species are described, and special emphasis is given to therapeutic trials against MNU-induced mammary cancer and retinal degeneration in animal models.

Published
2011

44. Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells.

Author

Kanematsu S, Uehara N, Miki H, Yoshizawa K, Kawanaka A, Yuri T, and Tsubura A

Subjects
Blotting, Western, Breast Neoplasms metabolism, Cell Line, Tumor, Cell Separation, Enzyme Inhibitors pharmacology, Female, Flow Cytometry, Fluorescent Antibody Technique, Humans, Isothiocyanates, Microscopy, Electron, Transmission, Signal Transduction drug effects, Sulfoxides, Anticarcinogenic Agents pharmacology, Apoptosis drug effects, Autophagy drug effects, Breast Neoplasms pathology, Cell Proliferation drug effects, Thiocyanates pharmacology
Abstract

Aim: Sulforaphane (SFN), which is present in cruciferous vegetables, induces growth arrest and/or cell death in cancer of various organs. The involvement of autophagy in the SFN-induced apoptotic death of human breast cancer cells was investigated., Materials and Methods: Cell proliferation and viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and trypan blue exclusion assay. Flow cytometry, immunofluorescence, electron microscopy, and Western blot analysis were used for detection of apoptosis and autophagy, and the role of autophagy was assessed using autophagy inhibitors., Results: SFN dose- and time-dependently retarded the growth and induced cell death in MCF-7 and MDA-MB-231 human breast cancer cells. In MDA-MB-231 cells, 30 μM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels. Cell death was due to apoptosis with increased caspase-3 and lowered BCL-2 levels. In addition, the SFN-treated cells exhibited autophagy, as characterized by the appearance of autophagic vacuoles by electron microscopy, the accumulation of acidic vesicular organelles by flow cytometry, and the punctuate patterns of microtubule-associated protein 1 light chain 3 (LC3) by fluorescein microscopy. The levels of LC3-I and -II proteins (processed forms of LC3-I) and LC3 mRNA were increased. Treatment with autophagy inhibitor bafilomycin A1 (but not 3-methyladenine) with SFN significantly enhanced apoptosis, which was accompanied by increases in the level of BAX and the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP)-1 and decreases in the mitochondrial membrane potential (ΔΨm)., Conclusion: These results indicate a cytoprotective role of autophagy against SFN-induced apoptosis and that the combination of SFN treatment with autophagy inhibition may be a promising strategy for breast cancer control.

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results