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Pretreatment Serum Carbohydrate Antigen 19-9 Concentration Is a Predictor of Survival of Patients Who Have Undergone Curative Resection of Stage IV Rectal Cancer.
- Source :
-
Digestive Surgery . Aug2018, Vol. 35 Issue 5, p389-396. 8p. 4 Charts, 1 Graph. - Publication Year :
- 2018
-
Abstract
- <bold>Background:</bold> To evaluate whether pretreatment carcinoembryonic antigen and carbohydrate antigen (CA)19-9 are useful predictors of survival in patients with stage IV rectal cancer who have undergone curative resection. <bold>Methods:</bold> In this retrospective study, data on 73 patients who had undergone curative resection of stage IV rectal cancer were reviewed. Associations between various clinicopathological factors and survival outcomes were analyzed. <bold>Results:</bold> According to univariate analysis, elevated pretreatment CA19-9 (p = 0.0028), R1 resection (p = 0.0318), and mucinous or poorly differentiated adenocarcinoma (p = 0.0228) were significantly associated with poor overall survival (OS), and lymph node metastasis (p = 0.0211) was significantly associated with poor disease-free survival (DFS). Multivariate analyses showed that elevated pretreatment serum CA19-9 concentration (hazard ratios [HR] 3.33; 95% CI 1.24-9.42; p = 0.0174) was an independent predictor for OS and lymph node metastasis (HR 2.26; 95% CI 1.15-4.82; p = 0.0164) was an independent predictor for DFS. Among 55 patients with recurrences after curative resection, the rate of complete resection of recurrences was significantly higher in patients with normal pretreatment CA19-9 than in those with elevated CA19-9 (p = 0.049). Post-recurrence survival was significantly worse in patients with elevated pretreatment CA19-9 than in those with normal CA19-9 (p = 0.0196). <bold>Conclusions:</bold> Pretreatment CA19-9 is good predictor of survival after curative resection of stage IV rectal cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARCINOEMBRYONIC antigen
*CA 19-9 test
Subjects
Details
- Language :
- English
- ISSN :
- 02534886
- Volume :
- 35
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Digestive Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 131398655
- Full Text :
- https://doi.org/10.1159/000480247