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1. Longitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD

Author

Lee, Arthur M., Xu, Yunwen, Hu, Jian, Xiao, Rui, Hooper, Stephen R., Hartung, Erum A., Coresh, Josef, Rhee, Eugene P., Vasan, Ramachandran S., Kimmel, Paul L., Warady, Bradley A., Furth, Susan L., Denburg, Michelle R., Abraham, Alison, Anderson, Amanda, Ballard, Shawn, Bonventre, Joseph, Clish, Clary, Collins, Heather, Coca, Steven, Coresh, Josef, Deo, Rajat, Denburg, Michelle, Dubin, Ruth, Feldman, Harold I., Ferket, Bart S., Foster, Meredith, Furth, Susan, Ganz, Peter, Gossett, Daniel, Grams, Morgan, Greenberg, Jason, Gutiérrez, Orlando M., Hostetter, Tom, Inker, Lesley A., Ix, Joachim, Kimmel, Paul L., Klein, Jon, Levey, Andrew S., Massaro, Joseph, McMahon, Gearoid, Mifflin, Theodore, Nadkarni, Girish N., Parikh, Chirag, Ramachandran, Vasan S., Rebholz, Casey, Rhee, Eugene, Rovin, Brad, Sarnak, Mark, Sabbisetti, Venkata, Schelling, Jeffrey, Seegmiller, Jesse, Shlipak, Michael G., Shou, Haochang, Tin, Adriene, Waikar, Sushrut, Warady, Bradley, Whitehead, Krista, and Xie, Dawei

Published
2024
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2. Plasma Kidney Injury Molecule 1 in CKD: Findings From the Boston Kidney Biopsy Cohort and CRIC Studies

Author

Schmidt, Insa M, Srivastava, Anand, Sabbisetti, Venkata, McMahon, Gearoid M, He, Jiang, Chen, Jing, Kusek, John W, Taliercio, Jonathan, Ricardo, Ana C, Hsu, Chi-yuan, Kimmel, Paul L, Liu, Kathleen D, Mifflin, Theodore E, Nelson, Robert G, Vasan, Ramachandran S, Xie, Dawei, Zhang, Xiaoming, Palsson, Ragnar, Stillman, Isaac E, Rennke, Helmut G, Feldman, Harold I, Bonventre, Joseph V, Waikar, Sushrut S, and Investigators, Chronic Kidney Disease Biomarkers Consortium and the CRIC Study

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Renal and urogenital, Good Health and Well Being, Biomarkers, Biopsy, Boston, Cohort Studies, Cross-Sectional Studies, Disease Progression, Humans, Kidney, Prospective Studies, Renal Insufficiency, Chronic, Chronic Kidney Disease Biomarkers Consortium and the CRIC Study Investigators, Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Rationale & objectivePlasma kidney injury molecule 1 (KIM-1) is a sensitive marker of proximal tubule injury, but its association with risks of adverse clinical outcomes across a spectrum of kidney diseases is unknown.Study designProspective, observational cohort study.Setting & participants524 individuals enrolled into the Boston Kidney Biopsy Cohort (BKBC) Study undergoing clinically indicated native kidney biopsy with biopsy specimens adjudicated for semiquantitative scores of histopathology by 2 kidney pathologists and 3,800 individuals with common forms of chronic kidney disease (CKD) enrolled into the Chronic Renal Insufficiency Cohort (CRIC) Study.ExposureHistopathologic lesions and clinicopathologic diagnosis in cross-sectional analyses, baseline plasma KIM-1 levels in prospective analyses.OutcomesBaseline plasma KIM-1 levels in cross-sectional analyses, kidney failure (defined as initiation of kidney replacement therapy) and death in prospective analyses.Analytical approachMultivariable-adjusted linear regression models tested associations of plasma KIM-1 levels with histopathologic lesions and clinicopathologic diagnoses. Cox proportional hazards models tested associations of plasma KIM-1 levels with future kidney failure and death.ResultsIn the BKBC Study, higher plasma KIM-1 levels were associated with more severe acute tubular injury, tubulointerstitial inflammation, and more severe mesangial expansion after multivariable adjustment. Participants with diabetic nephropathy, glomerulopathies, and tubulointerstitial disease had significantly higher plasma KIM-1 levels after multivariable adjustment. In the BKBC Study, CKD in 124 participants progressed to kidney failure and 85 participants died during a median follow-up time of 5 years. In the CRIC Study, CKD in 1,153 participants progressed to kidney failure and 1,356 participants died during a median follow-up time of 11.5 years. In both cohorts, each doubling of plasma KIM-1 level was associated with an increased risk of kidney failure after multivariable adjustment (hazard ratios of 1.19 [95% CI, 1.03-1.38] and 1.10 [95% CI, 1.06-1.15] for BKBC and CRIC, respectively). There was no statistically significant association of plasma KIM-1 levels with death in either cohort.LimitationsGeneralizability and unmeasured confounding.ConclusionsPlasma KIM-1 is associated with underlying tubulointerstitial and mesangial lesions and progression to kidney failure in 2 cohort studies of individuals with kidney diseases.

Published
2022

3. Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD

Author

Lee, Arthur M., Xu, Yunwen, Hooper, Stephen R., Abraham, Alison G., Hu, Jian, Xiao, Rui, Matheson, Matthew B., Brunson, Celina, Rhee, Eugene P., Coresh, Josef, Vasan, Ramachandran S., Schrauben, Sarah, Kimmel, Paul L., Warady, Bradley A., Furth, Susan L., Hartung, Erum A., Denburg, Michelle R., Abraham, Alison, Anderson, Amanda, Ballard, Shawn, Bonventre, Joseph, Clish, Clary, Collins, Heather, Coca, Steven, Coresh, Josef, Deo, Rajat, Denburg, Michelle, Dubin, Ruth, Feldman, Harold I., Ferket, Bart S., Foster, Meredith, Furth, Susan, Ganz, Peter, Gossett, Daniel, Grams, Morgan, Greenberg, Jason, Gutiérrez, Orlando M., Hostetter, Tom, Inker, Lesley A., Ix, Joachim, Kimmel, Paul L., Klein, Jon, Levey, Andrew S., Massaro, Joseph, McMahon, Gearoid, Mifflin, Theodore, Nadkarni, Girish N., Parikh, Chirag, Ramachandran, Vasan S., Rebholz, Casey, Rhee, Eugene, Rovin, Brad, Sarnak, M., Sabbisetti, Venkata, Schelling, Jeffrey, Seegmiller, Jesse, Shlipak, Michael G., Shou, Haochang, Tin, Adriene, Waikar, Sushrut, Warady, Bradley, Whitehead, Krista, and Xie, Dawei

Published
2024
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4. Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease

Author

Massaro, Joseph, Clish, Clary, Denburg, Michelle, Furth, Susan, Warady, Bradley, Bonventre, Joseph, Waikar, Sushrut, McMahon, Gearoid, Sabbisetti, Venkata, Coresh, Josef, Grams, Morgan, Rebholz, Casey, Abraham, Alison, Tin, Adriene, Parikh, Chirag, Klein, Jon, Coca, Steven, Ferket, Bart S., Nadkarni, Girish N., Gossett, Daniel, Rovin, Brad, Levey, Andrew S., Inker, Lesley A., Foster, Meredith, Dubin, Ruth, Deo, Rajat, Anderson, Amanda, Mifflin, Theodore, Xie, Dawei, Shou, Haochang, Ballard, Shawn, Whitehead, Krista, Collins, Heather, Greenberg, Jason, Ganz, Peter, Sapa, Hima, Gutiérrez, Orlando M., Shlipak, Michael G., Katz, Ronit, Ix, Joachim H., Sarnak, Mark J., Cushman, Mary, Rhee, Eugene P., Kimmel, Paul L., Vasan, Ramachandran S., Schrauben, Sarah J., Feldman, Harold I., Seegmiller, Jesse C., Brunengraber, Henri, Hostetter, Thomas H., and Schelling, Jeffrey R.

Published
2022
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5. Biological Variability of Estimated GFR and Albuminuria in CKD.

Author

Waikar, Sushrut S, Rebholz, Casey M, Zheng, Zihe, Hurwitz, Shelley, Hsu, Chi-Yuan, Feldman, Harold I, Xie, Dawei, Liu, Kathleen D, Mifflin, Theodore E, Eckfeldt, John H, Kimmel, Paul L, Vasan, Ramachandran S, Bonventre, Joseph V, Inker, Lesley A, Coresh, Josef, and Chronic Kidney Disease Biomarkers Consortium Investigators

Subjects
Chronic Kidney Disease Biomarkers Consortium Investigators, Humans, Albuminuria, Creatinine, Intramolecular Oxidoreductases, beta 2-Microglobulin, Glomerular Filtration Rate, Urinalysis, Blood Chemical Analysis, Prognosis, Severity of Illness Index, Cross-Sectional Studies, Predictive Value of Tests, Adult, Aged, Middle Aged, Female, Male, Renal Insufficiency, Chronic, Lipocalins, Cystatin C, Biomarkers, beta trace protein, biological variability, biomarker, clinically meaningful differences, coefficient of variation, cystatin C, estimated glomerular filtration rate, filtration marker, intraindividual variation, kidney function, laboratory measurement, reproducibility, serum creatinine, urinary albumin-creatinine ratio, β(2)-microglobulin, Kidney Disease, Clinical Research, Renal and urogenital, Good Health and Well Being, Clinical Sciences, Public Health and Health Services, Urology & Nephrology
Abstract

Rationale & objectiveDetermining whether a change in estimated glomerular filtration rate (eGFR) or albuminuria is clinically significant requires knowledge of short-term within-person variability of the measurements, which few studies have addressed in the setting of chronic kidney disease.Study designCross-sectional study with multiple collections over less than 4 weeks.Setting & participantsClinically stable outpatients with chronic kidney disease (N=50; mean age, 56.8 years; median eGFR, 40mL/min/1.73m2; median urinary albumin-creatinine ratio (UACR), 173mg/g).ExposureRepeat measurements from serially collected samples across 3 study visits.OutcomesMeasurements of urine albumin concentration (UAC), UACR, and plasma creatinine, cystatin C, β2-microglobulin (B2M), and beta trace protein (BTP).Analytical approachWe calculated within-person coefficients of variation (CVw) values and corresponding reference change positive and negative (RCVpos and RCVneg) values using log-transformed measurements.ResultsMedian CVw (RCVpos; RCVneg) values of filtration markers were 5.4% (+16%; -14%) for serum creatinine, 4.1% (+12%; -11%) for cystatin C, 7.4% (+23%; -18%) for BTP, and 5.6% (+17%; -14%) for B2M. Results for albuminuria were 33.2% (+145%; -59%) for first-morning UAC, 50.6% (+276%; -73%) for random spot UAC, 32.5% (+141%; -58%) for first-morning UACR, and 29.7% (124%; -55%) for random spot UACR. CVw values for filtration markers were comparable across the range of baseline eGFRs. CVw values for UAC and UACR were comparable across the range of baseline albuminuria values.LimitationsSmall sample size limits the ability to detect differences in variability across markers. Participants were recruited and followed up in a clinical and not research setting, so some preanalytical factors could not be controlled.ConclusionseGFR markers appear to have relatively low short-term within-person variability, whereas variability in albuminuria appears to be high, making it difficult to distinguish random variability from meaningful biologic changes.

Published
2018

6. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.

Author

Hsu, Chi-Yuan, Xie, Dawei, Waikar, Sushrut S, Bonventre, Joseph V, Zhang, Xiaoming, Sabbisetti, Venkata, Mifflin, Theodore E, Coresh, Josef, Diamantidis, Clarissa J, He, Jiang, Lora, Claudia M, Miller, Edgar R, Nelson, Robert G, Ojo, Akinlolu O, Rahman, Mahboob, Schelling, Jeffrey R, Wilson, Francis P, Kimmel, Paul L, Feldman, Harold I, Vasan, Ramachandran S, Liu, Kathleen D, CRIC Study Investigators, and CKD Biomarkers Consortium

Subjects
CRIC Study Investigators, CKD Biomarkers Consortium, Kidney Tubules, Humans, Kidney Failure, Chronic, Albuminuria, Disease Progression, Creatinine, Acetylglucosaminidase, Glomerular Filtration Rate, Proportional Hazards Models, Risk Assessment, Risk Factors, Follow-Up Studies, Prospective Studies, Aged, Middle Aged, Female, Male, Fatty Acid-Binding Proteins, Renal Insufficiency, Chronic, Biomarkers, Lipocalin-2, Hepatitis A Virus Cellular Receptor 1, chronic kidney disease, microalbuminuria, proteinuria, Kidney Disease, Patient Safety, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Renal and urogenital, Good Health and Well Being, Clinical Sciences, Urology & Nephrology
Abstract

Few investigations have evaluated the incremental usefulness of tubular injury biomarkers for improved prediction of chronic kidney disease (CKD) progression. As such, we measured urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, N-acetyl-ß-D-glucosaminidase and liver fatty acid binding protein under highly standardized conditions among 2466 enrollees of the prospective Chronic Renal Insufficiency Cohort Study. During 9433 person-years of follow-up, there were 581 cases of CKD progression defined as incident end-stage renal disease or halving of the estimated glomerular filtration rate. Levels of the urine injury biomarkers, normalized for urine creatinine, were strongly associated with CKD progression in unadjusted Cox proportional hazard models with hazard ratios in the range of 7 to 15 comparing the highest with the lowest quintiles. However, after controlling for the serum creatinine-based estimated glomerular filtration rate and urinary albumin/creatinine ratio, none of the normalized biomarkers was independently associated with CKD progression. None of the biomarkers improved on the high (0.89) C-statistic for the base clinical model. Thus, among patients with CKD, risk prediction with a clinical model that includes the serum creatinine-based estimated glomerular filtration rate and the urinary albumin/creatinine ratio is not improved on with the addition of renal tubular injury biomarkers.

Published
2017

7. Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies.

Author

Waikar, Sushrut S, Sabbisetti, Venkata, Ärnlöv, Johan, Carlsson, Axel C, Coresh, Josef, Feldman, Harold I, Foster, Meredith C, Fufaa, Gudeta D, Helmersson-Karlqvist, Johanna, Hsu, Chi-Yuan, Kimmel, Paul L, Larsson, Anders, Liu, Yumin, Lind, Lars, Liu, Kathleen D, Mifflin, Theodore E, Nelson, Robert G, Risérus, Ulf, Vasan, Ramachandran S, Xie, Dawei, Zhang, Xiaoming, Bonventre, Joseph V, and Chronic Kidney Disease Biomarkers Consortium Investigators

Subjects
Chronic Kidney Disease Biomarkers Consortium Investigators, Kidney Tubules, Proximal, Humans, Albuminuria, Risk Factors, Prospective Studies, Adult, Aged, Middle Aged, Sweden, Female, Male, Renal Insufficiency, Chronic, Young Adult, Biomarkers, Hepatitis A Virus Cellular Receptor 1, KIM-1, albuminuria, chronic kidney disease, Kidney Disease, Physical Injury - Accidents and Adverse Effects, Clinical Research, Renal and urogenital, Good Health and Well Being, Clinical Sciences, Urology & Nephrology
Abstract

BackgroundThe primary biomarkers used to define CKD are serum creatinine and albuminuria. These biomarkers have directed focus on the filtration and barrier functions of the kidney glomerulus even though albuminuria results from tubule dysfunction as well. Given that proximal tubules make up ∼90% of kidney cortical mass, we evaluated whether a sensitive and specific marker of proximal tubule injury, urinary kidney injury molecule-1 (KIM-1), is elevated in individuals with CKD or with risk factors for CKD.MethodsWe measured urinary KIM-1 in participants of five cohort studies from the USA and Sweden. Participants had a wide range of kidney function and were racially and ethnically diverse. Multivariable linear regression models were used to test the association of urinary KIM-1 with demographic, clinical and laboratory values.ResultsIn pooled, multivariable-adjusted analyses, log-transformed, creatinine-normalized urinary KIM-1 levels were higher in those with lower eGFR {β = -0.03 per 10 mL/min/1.73 m(2) [95% confidence interval (CI) -0.05 to -0.02]} and greater albuminuria [β = 0.16 per unit of log albumin:creatinine ratio (95% CI 0.15-0.17)]. Urinary KIM-1 levels were higher in current smokers, lower in blacks than nonblacks and lower in users versus nonusers of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.ConclusionProximal tubule injury appears to be an integral and measurable element of multiple stages of CKD.

Published
2016

8. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus

Author

Fufaa, Gudeta D, Weil, E Jennifer, Nelson, Robert G, Hanson, Robert L, Bonventre, Joseph V, Sabbisetti, Venkata, Waikar, Sushrut S, Mifflin, Theodore E, Zhang, Xiaoming, Xie, Dawei, Hsu, Chi-yuan, Feldman, Harold I, Coresh, Josef, Vasan, Ramachandran S, Kimmel, Paul L, Liu, Kathleen D, and for the Chronic Kidney Disease Biomarkers Consortium Investigators

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Kidney Disease, Renal and urogenital, Good Health and Well Being, Acute-Phase Proteins, Adolescent, Adult, Aged, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Fatty Acid-Binding Proteins, Female, Hepatitis A Virus Cellular Receptor 1, Humans, Incidence, Indians, North American, Kidney Failure, Chronic, Lipocalin-2, Lipocalins, Male, Membrane Glycoproteins, Middle Aged, Neoplasm Proteins, Proto-Oncogene Proteins, Receptors, Virus, Young Adult, Biomarkers, End-stage renal disease, Mortality, Type 2 diabetes, Chronic Kidney Disease Biomarkers Consortium Investigators, Clinical Sciences, Paediatrics and Reproductive Medicine, Public Health and Health Services, Endocrinology & Metabolism, Clinical sciences, Public health
Abstract

Aims/hypothesisKidney injury molecule 1 (KIM-1), liver fatty acid-binding protein (L-FABP), N-acetyl-β-D-glucosaminidase (NAG) and neutrophil gelatinase-associated lipocalin (NGAL) are urinary biomarkers of renal tubular injury. We examined their association with incident end-stage renal disease (ESRD) and all-cause mortality in American Indians with type 2 diabetes.MethodsBiomarker concentrations were measured in baseline urine samples in 260 Pima Indians who were followed for a median of 14 years. HRs were reported per SD of creatinine (Cr)-normalised log-transformed KIM-1, NAG and NGAL, and for three categories of L-FABP.ResultsDuring follow-up, 74 participants developed ESRD and 101 died. Median concentrations of KIM-1/Cr, NAG/Cr and NGAL/Cr and the proportion of detectable L-FABP were highest in those with macroalbuminuria (p

Published
2015

9. Biological Variability of Estimated GFR and Albuminuria in CKD

Author

Ramachandran, Vasan S., Bonventre, Joseph, Waikar, Sushrut, Sabbisetti, Venkata, Van Eyk, Jennifer, Chen, Dawn, Fu, Qin, Brunner, Hermine, D’Agati, Vivette, Barasch, Jonathan, Coresh, Josef, Rebholz, Casey, Go, Alan S., Bottinger, Erwin, Teixeira, Avelino, Daehn, Ilse, Molitch, Mark, Batlle, Daniel, Rovin, Brad, Wu, Haifeng, Levey, Andrew S., Inker, Lesley A., Foster, Meredith, Hsu, Chi-yuan, Liu, Kathleen, Klein, Jon, Mauer, Michael, Fioretto, Paola, Nelsestuen, Gary, Eckfeldt, John H., Karger, Amy, Feldman, Harold I., Ballard, Shawn, Whitehead, Krista, Xie, Dawei, Gimotty, Phyllis, Shou, Haochang, Zhang, Xiaoming, Ryan, Kellie, Mifflin, Theodore E., Greene, Tom, Nelson, Robert G., Kimmel, Paul L., Kusek, John W., Waikar, Sushrut S., Rebholz, Casey M., Zheng, Zihe, Hurwitz, Shelley, Liu, Kathleen D., Vasan, Ramachandran S., and Bonventre, Joseph V.

Published
2018
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10. Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression

Author

Schlosser, Pascal, Surapaneni, Aditya L., Borisov, Oleg, Schmidt, Insa M., Zhou, Linda, Anderson, Amanda, Deo, Rajat, Dubin, Ruth, Ganz, Peter, He, Jiang, Kimmel, Paul L., Li, Hongzhe, Nelson, Robert G., Porter, Anna C., Rahman, Mahboob, Rincon-Choles, Hernan, Shah, Vallabh, Unruh, Mark L., Vasan, Ramachandran S., Zheng, Zihe, Feldman, Harold I., Waikar, Sushrut S., Köttgen, Anna, Rhee, Eugene P., Coresh, Josef, Grams, Morgan E., Anderson, Amanda H., Appel, Lawrence J., Chen, Jing, Cohen, Debbie L., Dember, Laura M., Go, Alan S., Lash, James P., Rao, Panduranga S., Waikar, Sushrut, Schelling, Jeffrey, Denburg, Michelle, Furth, Susan, Warady, Bradley, Bonventre, Joseph, McMahon, Gearoid, Sabbisetti, Venkata, Coresh, Josef, Grams, Morgan, Rebholz, Casey, Abraham, Alison, Tin, Adriene, Parikh, Chirag, Klein, Jon, Coca, Steven, Ferket, Bart S., Nadkarni, Girish N., Rhee, Eugene, Kimmel, Paul L., Gossett, Daniel, Rovin, Brad, Shlipak, Michael G., Sarnak, M., Levey, Andrew S., Inker, Lesley A., Foster, Meredith, Gutiérrez, Orlando M., Ix, Joachim, Dubin, Ruth, Seegmiller, Jesse, Hostetter, Tom, Deo, Rajat, Li, Hongzhe, Ren, Yue, Schrauben, Sarah J., Feldman, Harold I., Anderson, Amanda, Mifflin, Theodore, Xie, Dawei, Shou, Haochang, Ballard, Shawn, Whitehead, Krista, Collins, Heather, Ramachandran, Vasan S., Greenberg, Jason, and Ganz, Peter

Published
2024
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11. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression

Author

Appel, Lawrence J., Feldman, Harold I., Go, Alan S., He, Jiang, Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob, Townsend, Raymond R., Hsu, Chi-yuan, Xie, Dawei, Waikar, Sushrut S., Bonventre, Joseph V., Zhang, Xiaoming, Sabbisetti, Venkata, Mifflin, Theodore E., Coresh, Josef, Diamantidis, Clarissa J., Lora, Claudia M., Miller, Edgar R., Nelson, Robert G., Ojo, Akinlolu O., Schelling, Jeffrey R., Wilson, Francis P., Kimmel, Paul L., Vasan, Ramachandran S., and Liu, Kathleen D.

Published
2017
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12. Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease

Author

Sapa, Hima, primary, Gutiérrez, Orlando M., additional, Shlipak, Michael G., additional, Katz, Ronit, additional, Ix, Joachim H., additional, Sarnak, Mark J., additional, Cushman, Mary, additional, Rhee, Eugene P., additional, Kimmel, Paul L., additional, Vasan, Ramachandran S., additional, Schrauben, Sarah J., additional, Feldman, Harold I., additional, Seegmiller, Jesse C., additional, Brunengraber, Henri, additional, Hostetter, Thomas H., additional, Schelling, Jeffrey R., additional, Massaro, Joseph, additional, Clish, Clary, additional, Denburg, Michelle, additional, Furth, Susan, additional, Warady, Bradley, additional, Bonventre, Joseph, additional, Waikar, Sushrut, additional, McMahon, Gearoid, additional, Sabbisetti, Venkata, additional, Coresh, Josef, additional, Grams, Morgan, additional, Rebholz, Casey, additional, Abraham, Alison, additional, Tin, Adriene, additional, Parikh, Chirag, additional, Klein, Jon, additional, Coca, Steven, additional, Ferket, Bart S., additional, Nadkarni, Girish N., additional, Gossett, Daniel, additional, Rovin, Brad, additional, Levey, Andrew S., additional, Inker, Lesley A., additional, Foster, Meredith, additional, Dubin, Ruth, additional, Deo, Rajat, additional, Anderson, Amanda, additional, Mifflin, Theodore, additional, Xie, Dawei, additional, Shou, Haochang, additional, Ballard, Shawn, additional, Whitehead, Krista, additional, Collins, Heather, additional, Greenberg, Jason, additional, and Ganz, Peter, additional

Published
2022
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13. Urinary monocyte chemoattractant protein-1 and hepcidin and early diabetic nephropathy lesions in type 1 diabetes mellitus

Author

Fufaa, Gudeta D., Weil, E. Jennifer, Nelson, Robert G., Hanson, Robert L., Knowler, William C., Rovin, Brad H., Wu, Haifeng, Klein, Jon B., Mifflin, Theodore E., Feldman, Harold I., Vasan, Ramachandran S., Kimmel, Paul L., Kusek, John W., Mauer, Michael, Zinman, Bernard, Donnelly, Sandra, Canada, Toronto, Gardiner, Robert, Suissa, Samy, Drummond, Keith, Goodyer, Paul, Sinaiko, Alan, Strand, Trudy, Gubler, Marie Claire, and Klein, Ronald

Published
2015
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14. Reading the future: the increased relevance of laboratory medicine in the next century

Author

Felder, Robin A., Graves, Seam, and Mifflin, Theodore

Subjects
Twenty-first century -- Forecasts and trends, Forecasts and trends, Health care industry, Market trend/market analysis, Biomedical laboratories -- Forecasts and trends, Health care industry -- French Guiana -- Forecasts and trends, Medical care -- French Guiana, Medical technology -- Forecasts and trends, Medical laboratory technology -- Forecasts and trends, Medical laboratories -- Forecasts and trends
Abstract

With the countdown to the next millennium running out, it's only natural to look for deeper meaning in this chronological changeover. Using experience rather than tarot cards, these authors examine [...]

Published
1999

15. Longitudinal TNFR1 and TNFR2 and Kidney Outcomes: Results from AASK and VA NEPHRON-D

Author

Chen, Teresa K., Coca, Steven G., Estrella, Michelle M., Appel, Lawrence J., Coresh, Josef, Thiessen Philbrook, Heather, Obeid, Wassim, Fried, Linda F., Heerspink, Hiddo J.L., Ix, Joachim H., Shlipak, Michael G., Kimmel, Paul L., Parikh, Chirag R., Grams, Morgan E., Ramachandran, Vasan S., Massaro, Joseph, Clish, Clary, Schelling, Jeffrey, Denburg, Michelle, Furth, Susan, Warady, Bradley, Bonventre, Joseph, Waikar, Sushrut, McMahon, Gearoid, Sabbisetti, Venkata, Coresh, Josef, Grams, Morgan, Rebholz, Casey, Abraham, Alison, Tin, Adrienne, Parikh, Chirag, Klein, Jon, Coca, Steven, Ferket, Bart S, Nadkarni, Girish N., Rhee, Eugene, Kimmel, Paul L., Gossett, Daniel, Rovin, Brad, Shlipak, Michael G., Sarnak, M, Levey, Andrew S., Inker, Lesley A., Foster, Meredith, Guti?rrez, Orlando M., Ix, Joachim, Dubin, Ruth, Seegmiller, Jesse, Hostetter, Tom, Deo, Rajat, Feldman, Harold I., Anderson, Amanda, Mifflin, Theodore, Xie, Dawei, Shou, Haochang, Ballard, Shawn, Whitehead, Krista, Collins, Heather, Greenberg, Jason, and Ganz, Peter

Abstract

Recent research suggests that biomarkers of the TNF pathway (TNFR1 and TNFR2) are associated with worse kidney outcomes. Most of these studies, however, evaluated baseline levels rather than longitudinal changes. In two cohorts (AASK, which enrolled Black people with CKD attributed to hypertension, and VA NEPHRON-D, which enrolled veterans with albuminuric CKD and type 2 diabetes), greater longitudinal increases in serum or plasma TNFR1 and TNFR2 were associated with higher risks of ESKD in AASK and subsequent kidney function decline in VA NEPHRON-D. These associations were independent of baseline biomarker level and kidney function. Longitudinal trajectories in TNFR1 and TNFR2 may ultimately allow improved risk assessment for kidney failure in persons with CKD.

Published
2022
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20. Metabolite Biomarkers of CKD Progression in Children

Author

Denburg, Michelle R., Xu, Yunwen, Abraham, Alison G., Coresh, Josef, Chen, Jingsha, Grams, Morgan E., Feldman, Harold I., Kimmel, Paul L., Rebholz, Casey M., Rhee, Eugene P., Vasan, Ramachandran S., Warady, Bradley A., Furth, Susan L., Ramachandran, Vasan S., Massaro, Joseph, Clish, Clary, Schelling, Jeffrey, Denburg, Michelle, Furth, Susan, Warady, Bradley, Bonventre, Joseph, Waikar, Sushrut, McMahon, Gearoid, Sabbisetti, Venkata, Coresh, Josef, Grams, Morgan, Rebholz, Casey, Abraham, Alison, Tin, Adriene, Parikh, Chirag, Klein, Jon, Coca, Steven, Ferket, Bart S, Nadkarni, Girish N., Rhee, Eugene, Kimmel, Paul L., Gossett, Daniel, Rovin, Brad, Shlipak, Michael G., Sarnak, M, Levey, Andrew S., Inker, Lesley A., Foster, Meredith, Gutiérrez, Orlando M., Ix, Joachim, Dubin, Ruth, Seegmiller, Jesse, Hostetter, Tom, Deo, Rajat, Feldman, Harold I., Anderson, Amanda, Mifflin, Theodore, Xie, Dawei, Shou, Haochang, Ballard, Shawn, Whitehead, Krista, Collins, Heather, Greenberg, Jason, and Ganz, Peter

Published
2021
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21. Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study

Author

Foster, Meredith C., primary, Coresh, Josef, additional, Bonventre, Joseph V., additional, Sabbisetti, Venkata S., additional, Waikar, Sushrut S., additional, Mifflin, Theodore E., additional, Nelson, Robert G., additional, Grams, Morgan, additional, Feldman, Harold I., additional, Vasan, Ramachandran S., additional, Kimmel, Paul L., additional, Hsu, Chi-yuan, additional, and Liu, Kathleen D., additional

Published
2015
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22. Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium

Author

Hsu, Chi-yuan, primary, Ballard, Shawn, additional, Batlle, Daniel, additional, Bonventre, Joseph V., additional, Böttinger, Erwin P., additional, Feldman, Harold I., additional, Klein, Jon B., additional, Coresh, Josef, additional, Eckfeldt, John H., additional, Inker, Lesley A., additional, Kimmel, Paul L., additional, Kusek, John W., additional, Liu, Kathleen D., additional, Mauer, Michael, additional, Mifflin, Theodore E., additional, Molitch, Mark E., additional, Nelsestuen, Gary L., additional, Rebholz, Casey M., additional, Rovin, Brad H., additional, Sabbisetti, Venkata S., additional, Van Eyk, Jennifer E., additional, Vasan, Ramachandran S., additional, Waikar, Sushrut S., additional, Whitehead, Krista M., additional, and Nelson, Robert G., additional

Published
2015
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39. Determination of Penicillin Using an Immobilized Enzyme Electrode: An Undergraduate Experiment.

Author

Mifflin, Theodore E.

Abstract

Background information, procedures, and results are provided for an experiment in which students: (1) construct an immobilized penicillinase electrode; (2) evaluate electron response as a function of penicillin concentration; and (3) study effects of solvent compositions, ionic strength, and equilibrium time upon electrode response. (JN)

Published
1984

41. Development of Simple Devices for Control of Temperature above and below Ambient on Simple Pipetting Stations

Author

Mifflin, Theodore E. and Felder, Robin A.

Abstract

Robotic pipetting stations are becoming increasingly popular to perform a variety of different laboratory analyses, including use of biochemical, chemical, and molecular biology reactions. As molecular diagnostic (MDx) analyses are adapted to pipetting stations, their need for additional resources on the pipetting stations such as heating and cooling will also grow.We designed and constructed small (< 150 cm2) accessories for use on a popular pipetting station. Both have small footprints and were built using readily available components. The microplate heater could achieve set point temperature within 10 minutes of activation and exhibited minimal temperature variation. The cooler was designed to be a passively cooled resource that could contain up to 15 Eppendorf tubes and maintain the temperature at least 20 degrees below ambient for at least two hours. Both units have been used to automate a coupled series of molecular biology reactions that yield RNA aptamers.We believe these two devices can be widely utilized with minor modifications of any pipetting station that requires heating or cooling capabilities on the pipetting station's deck.

Published
1998
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42. Electrophoretic Assays of Amylase Isoenzymes and Isoforms

Author

Mifflin, Theodore E., Hortin, Glen, and Bruns, David E.

Abstract

Recent clinical studies have documented the importance of measuring the isoenzymes of amylase in serum. The electrophoretic methods available for estimating these isoenzymes differ in speed, sensitivity, resolution, cost and ease of use. Moreover, these methods exhibit clinically important advantages and disadvantages when compared with methods that use amylase inhibitors or monoclonal antibodies.

Published
1986
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43. Plasma Kidney Injury Molecule 1 in CKD: Findings From the Boston Kidney Biopsy Cohort and CRIC Studies

Author

Schmidt, Insa M., Srivastava, Anand, Sabbisetti, Venkata, McMahon, Gearoid M., He, Jiang, Chen, Jing, Kusek, John W., Taliercio, Jonathan, Ricardo, Ana C., Hsu, Chi-yuan, Kimmel, Paul L., Liu, Kathleen D., Mifflin, Theodore E., Nelson, Robert G., Vasan, Ramachandran S., Xie, Dawei, Zhang, Xiaoming, Palsson, Ragnar, Stillman, Isaac E., Rennke, Helmut G., Feldman, Harold I., Bonventre, Joseph V., and Waikar, Sushrut S.

Abstract

Plasma kidney injury molecule 1 (KIM-1) is a sensitive marker of proximal tubule injury, but its association with risks of adverse clinical outcomes across a spectrum of kidney diseases is unknown.

Published
2021
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44. Software Implementation of Biological Repository for Human Genetic Material

Author

Graves, B., Mifflin, Theodore, Kell, Steve, Gunderson, Jim, Geddy, Sarah, and Felder, Robin

Abstract

To provide biological specimens for scientific studies, the Medical Automation Research Center (MARC) designed and constructed a large-scale device that emphasizes the use of robotics and automation to integrate many associated laboratory operations. These included analysis, dilution, archival storage, and retrieval of purified human-derived specimens. Designers of automated biological repositories are challenged by complex engineering problems. In this paper, we present an overview of the biological repository (biorepository) and give details of the software architecture.

Published
2000
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