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160 results on '"Midena, Giulia"'

4. Aqueous Humor Cytokines in Idiopathic Epiretinal Membrane: Correlation with Disease Severity.

Author

Torresin, Tommaso, Greggio, Angelo, Frisina, Rino, Motta, Lorenzo, Gius, Irene, Midena, Giulia, and Midena, Edoardo

Abstract

Background: To analyze the concentration of aqueous humor (AH) cytokines in eyes with idiopathic epiretinal membrane (iERM) and to investigate their potential correlation with disease severity. Methods: Retrospective cross-sectional case-control institutional study. A total of 16 eyes of 16 iERM patients and 14 eyes of 14 age-matched healthy controls were enrolled. AH samples were analyzed for various biomarkers using a glass-chip protein array. Cytokines associated with inflammation, fibrosis, angiogenesis, and glial signal transduction were quantified. Results: Significant differences in cytokine concentration were observed between the iERM group and controls, with 19 cytokines elevated in the iERM group (among them IL-6, IL-8, PDGF-AB, PDGF-BB, TGFB-1, TGFB-2, TGFB-3, VEGF A, VEGF C, VEGF D, p < 0,05, 95% confidence interval). Correlation analysis revealed associations between cytokine levels and iERM severity. Notably, stages 2, 3, and 4 of iERM demonstrated increased levels of various biomarkers. Conclusions: This study provides insights into the complex molecular interactions underlying iERM pathogenesis, describing a correlation between neuroinflammation and iERM severity. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Outer Retinal and Choroidal Changes in Adolescents with Long-Lasting Type 1 Diabetes.

Author

Pilotto, Elisabetta, Cosmo, Eleonora, Torresin, Tommaso, Coppola, Marco, Gutierrez De Rubalcava Doblas, Joaquin, Midena, Giulia, Moretti, Carlo, and Midena, Edoardo

Subjects
TYPE 1 diabetes, RHODOPSIN, OPTICAL coherence tomography, INSULIN therapy, DIABETIC retinopathy
Abstract

This study aimed to assess outer retinal layer (ORL), retinal pigment epithelium (RPE), choroid (Ch) and choriocapillaris (CC) modifications in adolescents with long-lasting (>10 years) type 1 diabetes (T1D) without (noDR) or with diabetic retinopathy (DR). ORL and RPE thickness were measured at optical coherence tomography (OCT) macular scans. Vascular parameters of Ch and CC were quantified after elaboration of macular OCT-angiography (OCTA) images. Insulin dose and auxological and metabolic parameters were correlated with OCT and OCTA findings in patients. ORL thickness was higher in DR eyes than in noDR and healthy controls (HC), and RPE thickness was higher in noDR and DR eyes than in HC, with statistical significance for some sectors in noDR versus HC. No OCTA parameters of CC and Ch differed among groups, and no significant correlation was observed with auxological and metabolic parameters. In conclusion, ORL and RPE were both increased in adolescents with long-lasting T1D. Such changes were not associated with insulin dose and glycemia control, nor to any choroid or choriocapillaris flow change clinically detectable at OCTA, and they could be potential imaging biomarkers of disease progression. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Circulating miR-146a predicts glucocorticoid response in thyroid eye disease

Author

Manso, Jacopo, primary, Censi, Simona, additional, Clausi, Cristina, additional, Piva, Ilaria, additional, Zhu, Yi Hang, additional, Mondin, Alberto, additional, Pedron, Maria Chiara, additional, Barollo, Susi, additional, Bertazza, Loris, additional, Midena, Giulia, additional, Parrozzani, Raffaele, additional, and Mian, Caterina, additional

Published
2023
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16. Validation of an Automated Artificial Intelligence Algorithm for the Quantification of Major OCT Parameters in Diabetic Macular Edema

Author

Midena, Edoardo, primary, Toto, Lisa, additional, Frizziero, Luisa, additional, Covello, Giuseppe, additional, Torresin, Tommaso, additional, Midena, Giulia, additional, Danieli, Luca, additional, Pilotto, Elisabetta, additional, Figus, Michele, additional, Mariotti, Cesare, additional, and Lupidi, Marco, additional

Published
2023
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34. RETINAL VASCULAR ABNORMALITIES RELATED TO NEUROFIBROMATOSIS TYPE 1

Author

Parrozzani, Raffaele, primary, Frizziero, Luisa, additional, Trainiti, Sara, additional, Calciati, Andrea, additional, Londei, Davide, additional, Miglionico, Giacomo, additional, Trevisson, Eva, additional, Midena, Giulia, additional, Pilotto, Elisabetta, additional, and Midena, Edoardo, additional

Published
2021
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35. USH2A-Related Retinitis Pigmentosa: Staging of Disease Severity and Morpho-Functional Studies

Author

Falsini, Benedetto, primary, Placidi, Giorgio, additional, De Siena, Elisa, additional, Savastano, Maria Cristina, additional, Minnella, Angelo Maria, additional, Maceroni, Martina, additional, Midena, Giulia, additional, Ziccardi, Lucia, additional, Parisi, Vincenzo, additional, Bertelli, Matteo, additional, Maltese, Paolo Enrico, additional, Chiurazzi, Pietro, additional, and Rizzo, Stanislao, additional

Published
2021
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36. High-Dose-Rate Interstitial Brachytherapy (Interventional Radiotherapy) for Conjunctival Melanoma with Orbital Extension

Author

Pagliara, Monica Maria, primary, Tagliaferri, Luca, additional, Savino, Gustavo, additional, Fionda, Bruno, additional, D’Aviero, Andrea, additional, Lanza, Angela, additional, Lancellotta, Valentina, additional, Midena, Giulia, additional, Gambacorta, Maria Antonietta, additional, and Blasi, Maria Antonietta, additional

Published
2021
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41. Orbital and Eyelid B-Cell Lymphoma: A Multicenter Retrospective Study

Author

Savino, Gustavo, primary, Midena, Giulia, additional, Blasi, Maria Antonietta, additional, Battendieri, Remo, additional, Grimaldi, Gabriela, additional, Maceroni, Martina, additional, Tranfa, Fausto, additional, Napolitano, Pasquale, additional, Lanni, Vittoria, additional, and Iuliano, Adriana, additional

Published
2020
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44. RADIATION MACULOPATHY IS ANTICIPATED BY OCT HYPERREFLECTIVE RETINAL FOCI

Author

Parrozzani, Raffaele, Midena, Giulia, Frizziero, Luisa, Marchione, Giulia, and Midena, Edoardo

Abstract

To identify patients at risk for radiation macular edema (ME), we analyzed hyperreflective retinal foci (HRF) in retinal layers of irradiated eyes. HRF progressively and significantly increased in number after irradiation, until the appearance of ME, confirming their role as a clinical biomarker anticipating the appearance of radiation-induced ME.

Published
2022
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46. Uveal Melanoma with Thickness between 4 and 6 mm Treated with two Different Radioisotopes (I125 or Ru106): Single Institution Experience.

Author

TAGLIAFERRI, Luca, PAGLIARA, Monica Maria, FIONDA, Bruno, SCUPOLA, Andrea, BOLDRINI, Luca, CAPUTO, Carmela Grazia, LANCELLOTTA, Valentina, MARINO, Cesare, MIDENA, Giulia, AZARIO, Luigi, LENKOWICZ, Jacopo, GAMBACORTA, Maria Antonietta, VALENTINI, Vincenzo, and BLASI, Maria Antonietta

Subjects
RADIOISOTOPE therapy, CANCER patients, MEDICAL records, MELANOMA, RADIOISOTOPE brachytherapy, SURVIVAL, DECISION making in clinical medicine, UVEA cancer, TREATMENT effectiveness, RETROSPECTIVE studies, DESCRIPTIVE statistics, ACQUISITION of data methodology
Abstract

This study aims to evaluate if a disease thickness cut-off of 5 mm can be considered the best choice to select gamma emitter sources, as 125I, for the treatment of uveal melanomas. METHODS The records of patients affected by primary uveal melanoma and treated in our institutional IOC (Interventional Oncology Center) from December 2006 to December 2016 were retrospectively reviewed. Only patients with a disease thickness between 4 mm and 6 mm treated with 106Ru or 125I plaque were considered for this analysis. RESULTS Between December 2006 and December 2016, 107 patients (107 eyes) with UM received brachytherapy treatment with tumor thickness between 4 and 6 mm. Nine patients developed local recurrence while seven patients had distant metastases. No statistically significant difference (p=0.36) was observed between the two groups (125I versus 106Ru) concerning DFS. Five patients treated with 125I (19.2%) experienced radiation maculopathy; this finding is noteworthy because this toxicity was experienced by 21 patients treated with 106Ru (25.9%). CONCLUSION In this study, we report that the use of 125I seeds for UM with a thickness between 5 mm and 6 mm is not associated with a statistically significant increased risk of radiation maculopathy. It is desirable that further multicentric investigations may help to confirm the results of our study. [ABSTRACT FROM AUTHOR]

Published
2020
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47. HYPERREFLECTIVE RETINAL SPOTS IN NORMAL AND DIABETIC EYES

Author

Vujosevic, Stela, primary, Bini, Silvia, additional, Torresin, Tommaso, additional, Berton, Marianna, additional, Midena, Giulia, additional, Parrozzani, Raffaele, additional, Martini, Ferdinando, additional, Pucci, Porzia, additional, Daniele, Anna R., additional, Cavarzeran, Fabiano, additional, and Midena, Edoardo, additional

Published
2017
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50. Retinal Glial Cells in Von Hippel–Lindau Disease: A Novel Approach in the Pathophysiology of Retinal Hemangioblastoma.

Author

Pilotto, Elisabetta, Midena, Giulia, Torresin, Tommaso, De Mojà, Gilda, Bacelle, Maria Laura, Ferrara, Alfonso Massimiliano, Zovato, Stefania, and Midena, Edoardo

Subjects
*BIOMARKERS, *RETINAL ganglion cells, *IN vivo studies, *VON Hippel-Lindau disease, *CANCER, *COMPARATIVE studies, *CANCER patients, *OPTICAL coherence tomography, *DESCRIPTIVE statistics, *RETINAL diseases, *NEUROGLIA, *HEMANGIOMAS
Abstract

Simple Summary: The in vivo optical coherence tomography analysis of the biomarkers of retinal microglia and macroglia in Von Hippel–Lindau disease represents an innovative field of research. The different behavior of these glial cells in Von Hippel–Lindau patients provides new data regarding the pathophysiology of retinal hemangioblastoma, the most common ocular manifestation of this hereditary disorder. Moreover, these biomarkers show a different behavior in Von Hippel–Lindau patients in relation to the presence or absence of retinal hemangioblastoma. Therefore, we can hypothesize that retinal hemangioblastoma is mainly due to the activation of macroglia by previously activated microglial cells. Background: Von Hippel–Lindau (VHL) disease is a neoplastic syndrome caused by a mutation of the VHL tumor suppressor gene. Retinal hemangioblastoma (RH) is a vascularized tumor and represents the most common ocular manifestation of this disease. At the retinal level, VHL protein is able to regulate tumor growth, angiogenic factors, and neuroinflammation, probably stimulating retinal glial cells. The aim of the present study was to analyze in vivo the optical coherence tomography (OCT) biomarkers of retinal macroglia and microglia in a cohort of VHL patients. Methods: The mean thicknesses of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), and peripapillary retinal nerve fiber layer (pRNFL) were measured with OCT as biomarkers of retinal macroglia. OCT images were also analyzed to detect and quantify hyperreflective retinal foci (HRF), a biomarker of retinal activated microglia. Results: 61 eyes of 61 VHL patients (22 eyes (36.07%) with peripheral RH and 39 eyes (63.93%) without RH) and 28 eyes of 28 controls were evaluated. pRNFL was thinner in VHL patients (p < 0.05) and in VHL without RH (p < 0.01) compared to controls, and thicker in VHL patients with RH than in those without RH (p < 0.05). The thickness of mRNFL (p < 0.0001) and GCL (p < 0.05) was reduced in VHL patients and in VHL without RH compared to controls, whereas mRNFL (p < 0.0001) and GCL (p < 0.05) were increased in VHL patients with RH compared to those without RH. HRF were significantly higher in number in VHL patients and in VHL without RH, than in controls, and significantly lower (p < 0.05) in the eyes of VHL patients with RH, than in those without RH. Conclusions: The OCT analysis, which detects and allows to quantify the biomarkers of retinal microglia (HRF) and macroglia (pRNFL, mRNFL and GCL), showed a different behavior of these two retinal glial cells populations in VHL patients, related to the presence or absence of peripheral RH. These data allow to hypothesize a novel pathophysiologic pathway of retinal hemangioblastoma in VHL disease. [ABSTRACT FROM AUTHOR]

Published
2022
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