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Outer Retinal and Choroidal Changes in Adolescents with Long-Lasting Type 1 Diabetes.

Authors :
Pilotto, Elisabetta
Cosmo, Eleonora
Torresin, Tommaso
Coppola, Marco
Gutierrez De Rubalcava Doblas, Joaquin
Midena, Giulia
Moretti, Carlo
Midena, Edoardo
Source :
Journal of Clinical Medicine; Jan2024, Vol. 13 Issue 1, p229, 11p
Publication Year :
2024

Abstract

This study aimed to assess outer retinal layer (ORL), retinal pigment epithelium (RPE), choroid (Ch) and choriocapillaris (CC) modifications in adolescents with long-lasting (>10 years) type 1 diabetes (T1D) without (noDR) or with diabetic retinopathy (DR). ORL and RPE thickness were measured at optical coherence tomography (OCT) macular scans. Vascular parameters of Ch and CC were quantified after elaboration of macular OCT-angiography (OCTA) images. Insulin dose and auxological and metabolic parameters were correlated with OCT and OCTA findings in patients. ORL thickness was higher in DR eyes than in noDR and healthy controls (HC), and RPE thickness was higher in noDR and DR eyes than in HC, with statistical significance for some sectors in noDR versus HC. No OCTA parameters of CC and Ch differed among groups, and no significant correlation was observed with auxological and metabolic parameters. In conclusion, ORL and RPE were both increased in adolescents with long-lasting T1D. Such changes were not associated with insulin dose and glycemia control, nor to any choroid or choriocapillaris flow change clinically detectable at OCTA, and they could be potential imaging biomarkers of disease progression. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20770383
Volume :
13
Issue :
1
Database :
Complementary Index
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
174716253
Full Text :
https://doi.org/10.3390/jcm13010229