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978 results on '"Midena, Edoardo"'

6. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial

Author

Alezzandrini, Arturo, Francone, Anibal Andres, Bafalluy, Joaquín, Bainttein, Silvina, Luna Pinto, Jose, Saravia, Mario, Vidosevich, Matko, Zeolite, Carlos, Furno Sola, Federico, Chang, Andrew, Cornish, Elisa Eleanor Guida, Nguyen, Thanh, Findl, Oliver, Haas, Anton, Kralinger, Martina, Sacu, Stefan, Postelmans, Laurence Dominique, Farah, Michel, Maia, Mauricio, Nehemy, Marcio, Ali, Fareed, Brent, Michael, Dollin, Michael, Gonder, John, Kherani, Amin, Merkur, Andrew, Tuli, Raman, Lopera, Monica Marie, Rodriguez, Francisco, Bradvica, Mario, Ernest, Jan, Kalijurand, Kuldar, Noor, Kai, Cohen, Yves, Creuzot-Garcher, Catherine, De Bats, Flore, Devin, François, Français-Maury, Catherine, Kodjikian, Laurent, Korobelnik, Jean François, Le Mer, Yannick, Quaranta El Maftouhi, Maddalena, Razavi, Sam, Souied, Eric, Tadayoni, Ramin, Weber, Michel, Eter, Nicole, Feltgen, Nicolas, Grisanti, Salvatore, Walter, Peter, Liegl, Raffael, Lorenz, Katrin, Spital, Georg, Priglinger, Siegfried, Spitzer, Martin, Volker, Michael, Krohne, Tim, Jochmann, Claudia, Lohmann, Chris Patrick, Framme, Carsten, Kerenyi, Agnes, Papp, Andras, Seres, Andras, Toth-Molnar, Edit, Tsorbatzoglou, Alexis, Vajas, Atilla, Varsanyi, Balázs, Vogt, Gabor, Bar, Asaf, Eting, Eva, Hauser, David, Levy, Jamie, Mathalone, Nurit, Morori-Katz, Haia, Rosenblatt, Irit, Soudry-Zayit, Shiri, Trivizky, Omert, Bandello, Francesco, Ciardella, Antonio Pasquale, Figus, Michele, Giansanti, Fabrizio, Lanzetta, Paolo, Mariotti, Cesare, Mastropasqua, Leonardo, Midena, Edoardo, Parmeggiani, Francesco, Ricci, Federico, Simonelli, Francesca, Staurenghi, Giovanni, Viola, Francesco, Varano, Monica, Laganovska, Guna, Cisiecki, Sławomir, Jedrzejewski, Wojciech, Kaluzny, Jakub, Misiuk-Hojło, Marta, Abengoechea, Santiago, Iribarren, Javier Araiz, Ascaso, Franciso Javier, Cubero, Juan Manuel, Gallego-Pinazo, Roberto, Gomez-Ulla De Irazazabal, Francisco, Mestre, Ignasi Jürgens, Mones I Carilla, Jordi Manel, Montero Moreno, Javier, María Ruiz Moreno, José, Sararols Ramsay, Laura, Garcia Layana, Alfredo, Downey, Louise, Abraham, Prema, Alfaro, Daniel Virgil, Bagheri, Nika, Barbazetto, Irene, Benevento, Joseph, Bernstein, Paul, Bertolucci, George, Bhavsar, Abdhish, Bridges, William, Brooks, Jr, Harold Logan, Brown, Jamin, Brucker, Alexander, Calvo, Charles M., Capone, Antonio, Carlson, John, Chan, Clement, Chang, Emmanuel, Chan-Kai, Brian, Chaudhry, Nauman, Chen, Sanford, Csaky, Karl, Cummings, Howard, Danzig, Carl, Dessouki, Amr, Dyer, David, Eaton, Alexander, Eichenbaum, David, Faber, David, Feldman, Robert, Finnen, Neil, Freeman, William, Frenkel, Ronald, Gonzales, Christine, Gonzalez, Victor, Gross, John, Gupta, Sunil, Hall, Edward, Han, Min-Kyu, Heier, Jeffrey, Hershberger, Vrinda, Higgins, Patrick, Hsu, Jason, Ip, Michael, Jablon, Eric, Jewart, Brian, John, Vishak, Jonisch, Jonathan, Joondeph, Brian, Kay, Christine, Khanani, Arshad, Kokame, Gregg T., Kwun, Robert, Lai, Michael, Lally, David, Laud, Ketan, Lavina, Adrian, Lee, Michael, Lin, Phoebe, Lin, Haijiang, Manoharan, Niranjan, Marcus, Dennis, Martidis, Adam, McCabe, Frank, Nielsen, Jared, Osher, James, Palmer, James, Patel, Sunil, Pearlman, Joel, Perkins, Stephen, Pirouz, Ashkan, Qureshi, Jawad, Randolph, John, Piri, Niloofar, Rosenfeld, Phillip, Saperstein, David, Scartozzi, Richard, Schwartz, Steven, Sharma, Ashish, Sharma, Atul, Sheth, Veeral, Singer, Michael, Spinak, David, Suan, Eric, Tabandeh, Homayoun, Tabassian, Ali, Uchiyama, Eduardo, Varenhorst, Michael, Wagner, Alan, Warrow, David, Wells, III, John, Wong, Robert, Wong, Keye, Wykoff, Charles, Xavier, Samantha, Ysasaga, Edward, Khanani, Arshad M, Patel, Sunil S, Danzig, Carl J, Eichenbaum, David A, Wykoff, Charles C, Heier, Jeffrey S, Lally, David R, Monés, Jordi, Nielsen, Jared S, Sheth, Veeral S, Kaiser, Peter K, Clark, Julie, Zhu, Liansheng, Patel, Hersh, Tang, Justin, Desai, Dhaval, and Jaffe, Glenn J

Published
2023
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8. Randomized Phase 2b Study of Brimonidine Drug Delivery System Generation 2 for Geographic Atrophy in Age-related Macular Degeneration

Author

Chen, Fred, Guymer, Robyn, Korobelnik, Jean-Francois, Souied, Eric, Holz, Frank, Ziemssen, Focke, Bandello, Francesco, Campos, Emilio, Grignolo/Eandi, Chiara, Midena, Edoardo, Peiretti, Enrico, Staurenghi, Giovanni, Viola, Francesco, Bailey, Clare, Esposti, Simona Degli, Jackson, Timothy, Menon, Geeta, Pagliarini, Sergio, Quhill, Fahd, Antoszyk, Andrew, Brooks, Logan, Callanan, David, Csaky, Karl, Edwards, Albert, Eichenbaum, David, Freeman, William, Garg, Sunir, Ghuman, Avtar Thomas, Gonzalez, Victor, Gupta, Sunil, Hamilton, Richard, Khurana, Rahul, Kunimoto, Derek, Kuppermann, Baruch, Lauer, Andreas, Lee, Seong Young, Maturi, Raj, Patel, Sunil, Reddy, Rahul, Rich, Ryan, Rivellese, Mark, Rose, Steven, Segal, Zachary, Wong, Robert, Freeman, William R., Guymer, Robyn H., Garg, Sunir J., Chen, Fred K., Holz, Frank G., Patel, Sunil S., Kim, Kimmie, and López, Francisco J.

Published
2023
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11. The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries

Author

Fabian, Ido Didi, Abdallah, Elhassan, Abdullahi, Shehu U, Abdulqader, Rula A, Abdulrahaman, Aminatu A, Abouelnaga, Sherif, Ademola-Popoola, Dupe S, Adio, Adedayo, Afifi, Mahmoud A, Afshar, Armin R, Aggarwal, Priyanka, Aghaji, Ada E, Ahmad, Alia, Akib, Marliyanti NR, Akinsete, Adeseye, Al Harby, Lamis, Al Mesfer, Saleh, Al Ani, Mouroge H, Alarcón Portabella, Silvia, Al-Badri, Safaa AF, Alcasabas, Ana Patricia A, Al-Dahmash, Saad A, Alejos, Amanda, Alemany-Rubio, Ernesto, Alfa Bio, Amadou I, Alfonso Carreras, Yvania, Al-Haddad, Christiane E, Al-Hussaini, Hamoud HY, Ali, Amany M, Alia, Donjeta B, Al-Jadiry, Mazin F, Al-Jumaily, Usama, Alkatan, Hind M, All-Eriksson, Charlotta, Al-Mafrachi, Ali ARM, Almeida, Argentino A, Alsawidi, Khalifa M, Al-Shaheen, Athar ASM, Al-Shammary, Entissar H, Amankwaa-Frempong, Doreen, Amiruddin, Primawita O, Armytasari, Inggar, Astbury, Nicholas J, Atalay, Hatice T, Ataseven, Eda, Atchaneeyasakul, La-ongsri, Atsiaya, Rose, Autrata, Rudolf, Balaguer, Julia, Balayeva, Ruhengiz, Barranco, Honorio, Bartoszek, Paulina, Bartuma, Katarina, Bascaran, Covadonga, Bechrakis, Nikolaos E, Beck Popovic, Maja, Begimkulova, Ainura S, Benmiloud, Sarra, Berete, Rokia C, Berry, Jesse L, Bhaduri, Anirban, Bhat, Sunil, Bhattacharyya, Arpita, Biewald, Eva M, Binkley, Elaine, Blum, Sharon, Bobrova, Nadia, Boldt, H.C., Bonanomi, Maria Teresa BC, Bouda, Gabrielle C, Bouguila, Hédi, Brennan, Rachel C, Brichard, Bénédicte G, Buaboonnam, Jassada, Budiongo, Aléine, Burton, Matthew J, Calderón-Sotelo, Patricia, Calle Jara, Doris A, Camuglia, Jayne E, Cano, Miriam R, Capra, Michael, Caspi, Shani, Cassoux, Nathalie, Castela, Guilherme, Castillo, Luis, Català-Mora, Jaume, Cavieres, Isabel, Chandramohan, Arthika, Chantada, Guillermo L, Chaudhry, Shabana, Chawla, Bhavna, Chen, Wensi, Chiwanga, Faraja S, Chuluunbat, Tsengelmaa, Cieslik, Krzysztof, Clark, Antony, Cockcroft, Ruellyn L, Comsa, Codruta, Correa Llano, Maria G, Corson, Timothy W, Couitchere, Line, Cowan-Lyn, Kristin E, Csóka, Monika, Dangboon, Wantanee, Das, Anirban, Das, Pranab, Das, Sima, Davanzo, Jacquelyn M, Davidson, Alan, De Francesco, Sonia, De Potter, Patrick, Quintero D, Karina, Demirci, Hakan, Desjardins, Laurence, Díaz Coronado, Rosdali Y, Dimaras, Helen, Dodgshun, Andrew J, Donato Macedo, Carla R, Dragomir, Monica D, Du, Yi, Du Bruyn, Magritha, Du Plessis, Johannes, Dudeja, Gagan, Eerme, Katrin, Eka Sutyawan, I Wayan, El Kettani, Asmaa, Elbahi, Amal M, Elder, James E, Elhaddad, Alaa M, Elhassan, Moawia MA, Elzembely, Mahmoud M, Ericksen, Connor, Essuman, Vera A, Evina, Ted Grimbert A, Ezegwui, Ifeoma R, Fadoo, Zehra, Fandiño, Adriana C, Faranoush, Mohammad, Fasina, Oluyemi, Fernández, Delia DPG, Fernández-Teijeiro, Ana, Foster, Allen, Frenkel, Shahar, Fu, Ligia D, Fuentes-Alabi, Soad L, Garcia, Juan L, García Aldana, David, Garcia Pacheco, Henry N, Geel, Jennifer A, Ghassemi, Fariba, Girón, Ana V, Goenz, Marco A, Gold, Aaron S, Goldberg, Hila, Gole, Glen A, Gomel, Nir, Gonzalez, Efren, Gonzalez Perez, Graciela, González-Rodríguez, Liudmira, Gorfine, Malka, Graells, Jaime, Gregersen, Pernille A, Grigorovski, Nathalia DAK, Guedenon, Koffi M, Gunasekera, D Sanjeeva, Gündüz, Ahmet K, Gupta, Himika, Gupta, Sanjiv, Gupta, Vineeta, Hadjistilianou, Theodora, Hamel, Patrick, Hamid, Syed A, Hamzah, Norhafizah, Hansen, Eric D, Harbour, J William, Hartnett, M. Elizabeth, Hasanreisoglu, Murat, Muhammad, Hassan, Hassan, Sadiq, Hassan, Shadab, Hautz, Wojciech, Haydar, Huda, Hederova, Stanislava, Hessissen, Laila, Hongeng, Suradej, Hordofa, Diriba F, Hubbard, G. Baker, Hummelen, Marlies, Husakova, Kristina, Hussein Al-Janabi, Allawi N, Ibanga, Affiong, Ida, Russo, Ilic, Vesna R, Islamov, Ziyavuddin, Jairaj, Vivekaraj, Janjua, Teyyeb, Jeeva, Irfan, Ji, Xunda, Jo, Dong Hyun, Jones, Michael M, Kabesha Amani, Theophile B, Kabore, Rolande L, Kaliki, Swathi, Kalinaki, Abubakar, Kamsang, Pius, Kantar, Mehmet, Kapelushnik, Noa, Kardava, Tamar, Kebudi, Rejin, Keomisy, Jonny, Kepak, Tomas, Ketteler, Petra, Khan, Zohora J, Khaqan, Hussain A, Khetan, Vikas, Khodabande, Alireza, Khotenashvili, Zaza, Kim, Jonathan W, Kim, Jeong Hun, Kiratli, Hayyam, Kivela, Tero T., Klett, Artur, Koç, Irem, Kosh Komba Palet, Jess Elio, Krivaitiene, Dalia, Kruger, Mariana, Kulvichit, Kittisak, Kuntorini, Mayasari W, Kyara, Alice, Lam, Geoffrey C, Larson, Scott A, Latinović, Slobodanka, Laurenti, Kelly D, Lavy, Yotam, Lavric Groznik, Alenka, Leverant, Amy A, Li, Cairui, Li, Kaijun, Limbu, Ben, Liu, Chun-Hsiu, Quah, BoonLong, López, Juan P, Lukamba, Robert M, Luna-Fineman, Sandra, Lutfi, Delfitri, Lysytsia, Lesia, Madgar, Shiran, Magrath, George N, Mahajan, Amita, Maitra, Puja, Maka, Erika, Makimbetov, Emil K, Maktabi, Azza, Maldonado, Carlos, Mallipatna, Ashwin, Manudhane, Rebecca, Manzhuova, Lyazat, Martín-Begue, Nieves, Masud, Sidra, Matende, Ibrahim O, Mattosinho, Clarissa CDS, Matua, Marchelo, Mayet, Ismail, Mbumba, Freddy B, McKenzie, John D, Mehrvar, Azim, Mengesha, Aemero A, Menon, Vikas, Mercado, Gary John V, Mets, Marilyn B, Midena, Edoardo, Miller, Audra, Mishra, Divyansh KC, Mndeme, Furahini G, Mohamedani, Ahmed A, Mohammad, Mona T, Moll, Annette C, Montero, Margarita M, Moreira, Claude, Mruthyunjaya, Prithvi, Msina, Mchikirwa S, Msukwa, Gerald, Mudaliar, Sangeeta S, Muma, Kangwa I M, Munier, Francis L, Murray, Timothy G, Musa, Kareem O, Mushtaq, Asma, Musika, Anne A, Mustak, Hamzah, Mustapha, Tajudeen, Muyen, Okwen M, Myezo, Khumo H, Naidu, Gita, Naidu, Natasha, Nair, Akshay Gopinathan, Natarajan, Sundaram, Naumenko, Larisa, Ndoye Roth, Paule Aïda, Nency, Yetty M, Neroev, Vladimir, Ng, Yvonne, Nikitovic, Marina, Nkanga, Elizabeth D, Nkumbe, Henry E, Numbi, Marcel N, Nummi, Kalle, Nuruddin, Murtuza, Nyaywa, Mutale, Nyirenda, Chinsisi, Obono-Obiang, Ghislaine, Oliver, Scott CN, Oporto, Joaquin, Ortega-Hernández, Miriam, Oscar, Alexander H, Ossandon, Diego, Pagarra, Halimah, Paintsil, Vivian, Paiva, Luisa, Palanivelu, Mahesh Shanmugam, Papyan, Ruzanna, Parrozzani, Raffaele, Pascual Morales, Claudia R, Paton, Katherine E, Pe'er, Jacob, Peralta Calvo, Jesús, Perić, Sanja, Pham, Chau TM, Philbert, Remezo, Plager, David A, Pochop, Pavel, Polania, Rodrigo A., Polyakov, Vladimir, Ponce, Jimena, Qadir, Ali O, Qayyum, Seema, Qian, Jiang, Refaeli, David, Rahman, Ardizal, Rajkarnikar, Purnima, Ramanjulu, Rajesh, Ramasubramanian, Aparna, Ramirez-Ortiz, Marco A, Randhawa, Jasmeen K, Randrianarisoa, Hoby Lalaina, Raobela, Léa, Rashid, Riffat, Reddy, M.A., Renner, Lorna A, Reynders, David, Ribadu, Dahiru, Ritter-Sovinz, Petra, Rogowska, Anna, Rojanaporn, Duangnate, Romero, Livia, Roy, Soma R, Saab, Raya H, Saakyan, Svetlana, Sabhan, Ahmed H, Sagoo, Mandeep S, Said, Azza MA, Saiju, Rohit, Salas, Beatriz, San Román Pacheco, Sonsoles, Sánchez, Gissela L, Sanchez Orozco, Alma Janeth, Sayalith, Phayvanh, Scanlan, Trish A, Schlüter, Sabrina, Schwab, Christoph, Sedaghat, Ahad, Seth, Rachna, Sgroi, Mariana, Shah, Ankoor S, Shakoor, Shawkat A, Sharma, Manoj K, Sherief, Sadik T, Shields, Carol L, Sia, David, Siddiqui, Sorath Noorani, Sidi cheikh, Sidi, Silva, Sónia, Singh, Arun D, Singh, Usha, Singha, Penny, Sitorus, Rita S, Skalet, Alison H, Soebagjo, Hendrian D, Sorochynska, Tetyana, Ssali, Grace, Stacey, Andrew W, Staffieri, Sandra E, Stahl, Erin D, Steinberg, David M, Stones, David K, Strahlendorf, Caron, Suarez, Maria Estela Coleoni, Sultana, Sadia, Sun, Xiantao, Superstein, Rosanne, Supriyadi, Eddy, Surukrattanaskul, Supawan, Suzuki, Shigenobu, Svojgr, Karel, Sylla, Fatoumata, Tamamyan, Gevorg, Tan, Deborah, Tandili, Alketa, Tang, Jing, Tarrillo Leiva, Fanny F, Tashvighi, Maryam, Tateshi, Bekim, Teh, Kok Hoi, Tehuteru, Edi S, Teixeira, Luiz F, Tekavcic Pompe, Manca, Thawaba, Abdullah Dahan M, Theophile, Tuyisabe, Toledano, Helen, Trang, Doan L, Traoré, Fousseyni, Tripathy, Devjyoti, Tuncer, Samuray, Tyau-Tyau, Harba, Umar, Ali B, Unal, Emel, Uner, Ogul E, Urbak, Steen F, Ushakova, Tatiana L, Usmanov, Rustam H, Valeina, Sandra, Valente, Paola, van Hoefen Wijsard, Milo, Vasquez Anchaya, Jacqueline Karina, Vaughan, Leon O, Veleva-Krasteva, Nevyana V, Verma, Nishant, Victor, Andi A, Viksnins, Maris, Villacís Chafla, Edwin G, Villegas, Victor M, Vishnevskia-Dai, Victoria, Waddell, Keith, Wali, Amina H, Wang, Yi-Zhuo, Wangtiraumnuay, Nutsuchar, Wetter, Julie, Widiarti, Widiarti, Wilson, Matthew W, Wime, Amelia DC, Wiwatwongwana, Atchareeya, Wiwatwongwana, Damrong, Wolley Dod, Charlotte, Wong, Emily S, Wongwai, Phanthipha, Wu, Si-qi, Xiang, Daoman, Xiao, Yishuang, Xu, Bing, Xue, Kang, Yaghy, Antonio, Yam, Jason C, Yang, Huasheng, Yanga, Jenny M, Yaqub, Muhammad A, Yarovaya, Vera A, Yarovoy, Andrey A, Ye, Huijing, Yee, Roberto I, Yousef, Yacoub A, Yuliawati, Putu, Zapata López, Arturo M, Zein, Ekhtelbenina, Zhang, Yi, Zhilyaeva, Katsiaryna, Zia, Nida, Ziko, Othman AO, Zondervan, Marcia, and Bowman, Richard

Published
2022
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14. Aqueous Humor Cytokines in Idiopathic Epiretinal Membrane: Correlation with Disease Severity.

Author

Torresin, Tommaso, Greggio, Angelo, Frisina, Rino, Motta, Lorenzo, Gius, Irene, Midena, Giulia, and Midena, Edoardo

Abstract

Background: To analyze the concentration of aqueous humor (AH) cytokines in eyes with idiopathic epiretinal membrane (iERM) and to investigate their potential correlation with disease severity. Methods: Retrospective cross-sectional case-control institutional study. A total of 16 eyes of 16 iERM patients and 14 eyes of 14 age-matched healthy controls were enrolled. AH samples were analyzed for various biomarkers using a glass-chip protein array. Cytokines associated with inflammation, fibrosis, angiogenesis, and glial signal transduction were quantified. Results: Significant differences in cytokine concentration were observed between the iERM group and controls, with 19 cytokines elevated in the iERM group (among them IL-6, IL-8, PDGF-AB, PDGF-BB, TGFB-1, TGFB-2, TGFB-3, VEGF A, VEGF C, VEGF D, p < 0,05, 95% confidence interval). Correlation analysis revealed associations between cytokine levels and iERM severity. Notably, stages 2, 3, and 4 of iERM demonstrated increased levels of various biomarkers. Conclusions: This study provides insights into the complex molecular interactions underlying iERM pathogenesis, describing a correlation between neuroinflammation and iERM severity. [ABSTRACT FROM AUTHOR]

Published
2024
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15. A deep learning approach to hard exudates detection and disorganization of retinal inner layers identification on OCT images.

Author

Toto, Lisa, Romano, Anna, Pavan, Marco, Degl'Innocenti, Dante, Olivotto, Valentina, Formenti, Federico, Viggiano, Pasquale, Midena, Edoardo, and Mastropasqua, Rodolfo

Subjects
OPTICAL coherence tomography, DEEP learning, EXUDATES & transudates, DATA scrubbing, MACULAR edema, IMAGE analysis
Abstract

The purpose of the study was to detect Hard Exudates (HE) and classify Disorganization of Retinal Inner Layers (DRIL) implementing a Deep Learning (DL) system on optical coherence tomography (OCT) images of eyes with diabetic macular edema (DME). We collected a dataset composed of 442 OCT images on which we annotated 6847 HE and the presence of DRIL. A complex operational pipeline was defined to implement data cleaning and image transformations, and train two DL models. The state-of-the-art neural network architectures (Yolov7, ConvNeXt, RegNetX) and advanced techniques were exploited to aggregate the results (Ensemble learning, Edge detection) and obtain a final model. The DL approach reached good performance in detecting HE and classifying DRIL. Regarding HE detection the model got an AP@0.5 score equal to 34.4% with Precision of 48.7% and Recall of 43.1%; while for DRIL classification an Accuracy of 91.1% with Sensitivity and Specificity both of 91.1% and AUC and AUPR values equal to 91% were obtained. The P-value was lower than 0.05 and the Kappa coefficient was 0.82. The DL models proved to be able to identify HE and DRIL in eyes with DME with a very good accuracy and all the metrics calculated confirmed the system performance. Our DL approach demonstrated to be a good candidate as a supporting tool for ophthalmologists in OCT images analysis. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial

Author

Khanani, Arshad M, primary, Patel, Sunil S, additional, Staurenghi, Giovanni, additional, Tadayoni, Ramin, additional, Danzig, Carl J, additional, Eichenbaum, David A, additional, Hsu, Jason, additional, Wykoff, Charles C, additional, Heier, Jeffrey S, additional, Lally, David R, additional, Monés, Jordi, additional, Nielsen, Jared S, additional, Sheth, Veeral S, additional, Kaiser, Peter K, additional, Clark, Julie, additional, Zhu, Liansheng, additional, Patel, Hersh, additional, Tang, Justin, additional, Desai, Dhaval, additional, Jaffe, Glenn J, additional, Alezzandrini, Arturo, additional, Francone, Anibal Andres, additional, Bafalluy, Joaquín, additional, Bainttein, Silvina, additional, Luna Pinto, Jose, additional, Saravia, Mario, additional, Vidosevich, Matko, additional, Zeolite, Carlos, additional, Furno Sola, Federico, additional, Chang, Andrew, additional, Cornish, Elisa Eleanor Guida, additional, Nguyen, Thanh, additional, Findl, Oliver, additional, Haas, Anton, additional, Kralinger, Martina, additional, Sacu, Stefan, additional, Postelmans, Laurence Dominique, additional, Farah, Michel, additional, Maia, Mauricio, additional, Nehemy, Marcio, additional, Ali, Fareed, additional, Brent, Michael, additional, Dollin, Michael, additional, Gonder, John, additional, Kherani, Amin, additional, Merkur, Andrew, additional, Tuli, Raman, additional, Lopera, Monica Marie, additional, Rodriguez, Francisco, additional, Bradvica, Mario, additional, Ernest, Jan, additional, Kalijurand, Kuldar, additional, Noor, Kai, additional, Cohen, Yves, additional, Creuzot-Garcher, Catherine, additional, De Bats, Flore, additional, Devin, François, additional, Français-Maury, Catherine, additional, Kodjikian, Laurent, additional, Korobelnik, Jean François, additional, Le Mer, Yannick, additional, Quaranta El Maftouhi, Maddalena, additional, Razavi, Sam, additional, Souied, Eric, additional, Weber, Michel, additional, Eter, Nicole, additional, Feltgen, Nicolas, additional, Grisanti, Salvatore, additional, Walter, Peter, additional, Liegl, Raffael, additional, Lorenz, Katrin, additional, Spital, Georg, additional, Priglinger, Siegfried, additional, Spitzer, Martin, additional, Volker, Michael, additional, Krohne, Tim, additional, Jochmann, Claudia, additional, Lohmann, Chris Patrick, additional, Framme, Carsten, additional, Kerenyi, Agnes, additional, Papp, Andras, additional, Seres, Andras, additional, Toth-Molnar, Edit, additional, Tsorbatzoglou, Alexis, additional, Vajas, Atilla, additional, Varsanyi, Balázs, additional, Vogt, Gabor, additional, Bar, Asaf, additional, Eting, Eva, additional, Hauser, David, additional, Levy, Jamie, additional, Mathalone, Nurit, additional, Morori-Katz, Haia, additional, Rosenblatt, Irit, additional, Soudry-Zayit, Shiri, additional, Trivizky, Omert, additional, Bandello, Francesco, additional, Ciardella, Antonio Pasquale, additional, Figus, Michele, additional, Giansanti, Fabrizio, additional, Lanzetta, Paolo, additional, Mariotti, Cesare, additional, Mastropasqua, Leonardo, additional, Midena, Edoardo, additional, Parmeggiani, Francesco, additional, Ricci, Federico, additional, Simonelli, Francesca, additional, Viola, Francesco, additional, Varano, Monica, additional, Laganovska, Guna, additional, Cisiecki, Sławomir, additional, Jedrzejewski, Wojciech, additional, Kaluzny, Jakub, additional, Misiuk-Hojło, Marta, additional, Abengoechea, Santiago, additional, Iribarren, Javier Araiz, additional, Ascaso, Franciso Javier, additional, Cubero, Juan Manuel, additional, Gallego-Pinazo, Roberto, additional, Gomez-Ulla De Irazazabal, Francisco, additional, Mestre, Ignasi Jürgens, additional, Mones I Carilla, Jordi Manel, additional, Montero Moreno, Javier, additional, María Ruiz Moreno, José, additional, Sararols Ramsay, Laura, additional, Garcia Layana, Alfredo, additional, Downey, Louise, additional, Abraham, Prema, additional, Alfaro, Daniel Virgil, additional, Bagheri, Nika, additional, Barbazetto, Irene, additional, Benevento, Joseph, additional, Bernstein, Paul, additional, Bertolucci, George, additional, Bhavsar, Abdhish, additional, Bridges, William, additional, Brooks, Jr, Harold Logan, additional, Brown, Jamin, additional, Brucker, Alexander, additional, Calvo, Charles M., additional, Capone, Antonio, additional, Carlson, John, additional, Chan, Clement, additional, Chang, Emmanuel, additional, Chan-Kai, Brian, additional, Chaudhry, Nauman, additional, Chen, Sanford, additional, Csaky, Karl, additional, Cummings, Howard, additional, Danzig, Carl, additional, Dessouki, Amr, additional, Dyer, David, additional, Eaton, Alexander, additional, Eichenbaum, David, additional, Faber, David, additional, Feldman, Robert, additional, Finnen, Neil, additional, Freeman, William, additional, Frenkel, Ronald, additional, Gonzales, Christine, additional, Gonzalez, Victor, additional, Gross, John, additional, Gupta, Sunil, additional, Hall, Edward, additional, Han, Min-Kyu, additional, Heier, Jeffrey, additional, Hershberger, Vrinda, additional, Higgins, Patrick, additional, Ip, Michael, additional, Jablon, Eric, additional, Jewart, Brian, additional, John, Vishak, additional, Jonisch, Jonathan, additional, Joondeph, Brian, additional, Kay, Christine, additional, Khanani, Arshad, additional, Kokame, Gregg T., additional, Kwun, Robert, additional, Lai, Michael, additional, Lally, David, additional, Laud, Ketan, additional, Lavina, Adrian, additional, Lee, Michael, additional, Lin, Phoebe, additional, Lin, Haijiang, additional, Manoharan, Niranjan, additional, Marcus, Dennis, additional, Martidis, Adam, additional, McCabe, Frank, additional, Nielsen, Jared, additional, Osher, James, additional, Palmer, James, additional, Patel, Sunil, additional, Pearlman, Joel, additional, Perkins, Stephen, additional, Pirouz, Ashkan, additional, Qureshi, Jawad, additional, Randolph, John, additional, Piri, Niloofar, additional, Rosenfeld, Phillip, additional, Saperstein, David, additional, Scartozzi, Richard, additional, Schwartz, Steven, additional, Sharma, Ashish, additional, Sharma, Atul, additional, Sheth, Veeral, additional, Singer, Michael, additional, Spinak, David, additional, Suan, Eric, additional, Tabandeh, Homayoun, additional, Tabassian, Ali, additional, Uchiyama, Eduardo, additional, Varenhorst, Michael, additional, Wagner, Alan, additional, Warrow, David, additional, Wells, III, John, additional, Wong, Robert, additional, Wong, Keye, additional, Wykoff, Charles, additional, Xavier, Samantha, additional, and Ysasaga, Edward, additional

Published
2023
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30. Vision-Related Quality of Life in Patients with Diabetic Macular Edema Treated with Intravitreal Aflibercept: The AQUA Study

Author

Adan, Alfredo, Alexik, Mikulas, Ali, Fareed, Amaro, Miguel, Balciuniene, Vilma-Jurate, Bandello, Francesco M., Arias Barquet, Lluis, Beck, Anna, Bell, Katharina, Boscia, Francesco, Bures, Anniken, Carneiro, Ângela, Chow, David R., Cimbalas, Andrius, Dahlke, Claudia, Deepali, Varma, Dickinson, John D., Dollin, Michael, Eandi, Chiara, Emmerich, Karl-Heinz, Feltgen, Nicolas, Pereira Figueira, João, Findl, Oliver, Gajdošová, Monika, Gale, Richard P., John Galic, Ivan, Garweg, Justus, Gasser-Steiner, Vanessa, Giunta, Michel, Gonder, John R., Grzybowski, Andrzej, Hamouz, Jan, Hattenbach, Lars-Olof, Holz, Frank G., Jesia, Hasan, Kaluzny, Jozef, Kerenyi, Agnes, Kertes, Peter J., Koch, Frank, Kodjikan, Laurent, Lederer, David E., Liehneova, Ivana, Lorenz, Katrin, Lotery, Andrew J., McKibbin, Martin, Menon, Geeta V., Michalewska, Zofia, Midena, Edoardo, Nicolo, Massimo, Papp, Andras, Pavlovičová, Gabriela, Peiretti, Enrico, Vaz-Pereira, Sara, Perri, Paolo, Petropoulos, Ioannis, Queguiner, Frederic, Raczynska, Krystyna, Sararols-Ramsay, Laura, Rękas, Marek, Ricci, Federico, Romanowska-Dixon, Bozena, Sachs, Helmut G., Mohand-Said, Saddek, Sandner, Dirk, Schmidt-Erfurth, Ursula, Sekundo, Walter, Seres, Andras, Sivaprasad, Sobha, Souied, Eric, Castro de Sousa, João, Stankiewicz, Andrzej, Štefaničková, Jana, Struhárová, Katarína, Studnicka, Jan, Cervera Taulet, Enrique, Taylor, Simon, Teper, Slawomir, Vajas, Attila, Cava Valenciano, Carlos, Varsányi, Balázs, Viola, Francesco, Virgili, Gianni, Wagenfeld, Lars, Walters, Gavin, Wiedemann, Peter, Zarnowski, Tomasz, Garweg, Justus G., Stefanickova, Jana, Hoyng, Carel, Schmelter, Thomas, Niesen, Tobias, and Sowade, Olaf

Published
2019
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31. Outer Retinal and Choroidal Changes in Adolescents with Long-Lasting Type 1 Diabetes.

Author

Pilotto, Elisabetta, Cosmo, Eleonora, Torresin, Tommaso, Coppola, Marco, Gutierrez De Rubalcava Doblas, Joaquin, Midena, Giulia, Moretti, Carlo, and Midena, Edoardo

Subjects
TYPE 1 diabetes, RHODOPSIN, OPTICAL coherence tomography, INSULIN therapy, DIABETIC retinopathy
Abstract

This study aimed to assess outer retinal layer (ORL), retinal pigment epithelium (RPE), choroid (Ch) and choriocapillaris (CC) modifications in adolescents with long-lasting (>10 years) type 1 diabetes (T1D) without (noDR) or with diabetic retinopathy (DR). ORL and RPE thickness were measured at optical coherence tomography (OCT) macular scans. Vascular parameters of Ch and CC were quantified after elaboration of macular OCT-angiography (OCTA) images. Insulin dose and auxological and metabolic parameters were correlated with OCT and OCTA findings in patients. ORL thickness was higher in DR eyes than in noDR and healthy controls (HC), and RPE thickness was higher in noDR and DR eyes than in HC, with statistical significance for some sectors in noDR versus HC. No OCTA parameters of CC and Ch differed among groups, and no significant correlation was observed with auxological and metabolic parameters. In conclusion, ORL and RPE were both increased in adolescents with long-lasting T1D. Such changes were not associated with insulin dose and glycemia control, nor to any choroid or choriocapillaris flow change clinically detectable at OCTA, and they could be potential imaging biomarkers of disease progression. [ABSTRACT FROM AUTHOR]

Published
2024
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39. The ideal intravitreal injection setting: office, ambulatory surgery room or operating theatre? A narrative review and international survey.

Author

Veritti, Daniele, Sarao, Valentina, Chhablani, Jay, Loewenstein, Anat, Lanzetta, Paolo, Società Italiana della Retina (SIR) Study Group, Bandello, Francesco, Midena, Edoardo, Nicolò, Massimo, Parravano, Mariacristina, Pilotto, Elisabetta, Ricci, Federico, Staurenghi, Giovanni, Virgili, Gianni, Intravitreal Injection Setting Study Group (I2SG), Arnold, Jennifer J., Augustin, Albert J., Creuzot-Garcher, Catherine, Adrian, Monica Lövestam, and Mekjavić, Polona Jaki

Subjects
INTRAVITREAL injections, AMBULATORY surgery, MEDICAL offices, OPERATING rooms, LITERATURE reviews, VASCULAR endothelial growth factors
Abstract

Purpose: This study reviews evidence and provides recommendations for the ideal setting of intravitreal injection (IVI) administration of vascular endothelial growth factor (VEGF) inhibitors. Methods: A multi-step approach was employed, including content analysis of regulations and guidelines, a systematic literature review, and an international survey assessing perioperative complications and endophthalmitis incidence in relation to injection settings. The literature review searched PubMed and Cochrane databases from 2006 to 2022, focusing on studies reporting correlations between complications and treatment settings. The survey utilized a web-based questionnaire distributed to clinical sites and the international ophthalmic community, with data managed using electronic capture tools. Results: We reviewed regulations and guidelines from 23 countries across five continents, finding significant variation in IVI administration settings. In most countries, IVI is primarily administered in outpatient clean rooms (96%) or offices (39%), while in others, it is restricted to ambulatory surgery rooms or hospital-based operating theatres (4%). The literature review found that endophthalmitis risk after IVI is generally low (0.01% to 0.26% per procedure), with no significant difference between office-based and operating room settings. The international survey (20 centers, 96,624 anti-VEGF injections) found low overall incidences of severe perioperative systemic adverse events and endophthalmitis, independent of injection settings. Conclusion: No significant differences in perioperative complications were observed among various settings, including operating theatres, ambulatory surgery rooms, offices, hospitals, or extra-hospital environments. Choosing the appropriate clinical setting can optimize patient management, potentially increasing effectiveness, quality, productivity, and capacity. [ABSTRACT FROM AUTHOR]

Published
2023
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40. List of Contributors

Author

Abuduxikuer, Kuerbanjiang, primary, Aggarwal, Annu, additional, Amir, Achiya Zvi, additional, Annunziato, Rachel A., additional, Barbosa, Egberto R., additional, Bavdekar, Ashish, additional, Bhatt, Mohit, additional, Blindauer, Claudia A., additional, Borchard, Sabine, additional, C. Bull, Peter, additional, Cançado, Eduardo L.R., additional, Chang, Irene J., additional, Chiappe, Francesca, additional, Cobine, Paul A., additional, Coenen, Iris C.J., additional, Cox, Diane Wilson, additional, Członkowska, Anna, additional, Denk, Helmut, additional, Dhawan, Anil, additional, Dmitriev, Oleg Y., additional, Ferenci, Peter, additional, Frizziero, Luisa, additional, Frydman, Moshe, additional, Gupta, Arnab, additional, Hahn, Si Houn, additional, Harris, Zena Leah, additional, Hermann, Wieland, additional, Houwen, Roderick H.J., additional, Huster, Dominik, additional, Iorio, Raffaele, additional, Ivanova, Irena, additional, Jayakanthan, Samuel, additional, Jung, Sunhee, additional, Kaler, Stephen G., additional, Kerkar, Nanda, additional, Kieffer, Dorothy A., additional, Kirk, Richard, additional, Kyrana, Eirini, additional, Lackner, Carolin, additional, Latorre, Mauricio, additional, Lepori, Maria B., additional, Litwin, Tomasz, additional, Loudianos, Georgios, additional, Lutsenko, Svetlana, additional, Mak, Chloe M., additional, Medici, Valentina, additional, Midena, Edoardo, additional, Miloh, Tamir, additional, Parrozzani, Raffaele, additional, Polishchuk, Roman S., additional, Poujois, Aurélia, additional, Poupon, Joël, additional, Quindipan, Catherine, additional, Ranucci, Giusy, additional, Ray, Kunal, additional, Roberts, Eve A., additional, Rommens, Johanna, additional, Rongioletti, Mauro, additional, Rose, Carl, additional, Rosenthal, Philip, additional, Rupp, Christian, additional, Schiano, Thomas D., additional, Schilsky, Michael L., additional, Shteyer, Eyal, additional, Sintusek, Palittiya, additional, Siotto, Mariacristina, additional, Socha, Piotr, additional, Solioz, Marc, additional, Squitti, Rosanna, additional, Sussman, Norman L., additional, Tanner, Stuart, additional, Torbenson, Vanessa, additional, Troncoso, Rodrigo, additional, Uauy, Ricardo, additional, van de Sluis, Bart, additional, Vest, Katherine E., additional, Vierling, John M., additional, Walshe, John M., additional, Wang, Jian-She, additional, Weiss, Karl H., additional, Woimant, France, additional, Yi, Ling, additional, Zeid, Cynthia Abou, additional, Zhu, Xinyu, additional, Zimbrean, Paula C., additional, and Zischka, Hans, additional

Published
2019
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47. Validation of an Automated Artificial Intelligence Algorithm for the Quantification of Major OCT Parameters in Diabetic Macular Edema

Author

Midena, Edoardo, primary, Toto, Lisa, additional, Frizziero, Luisa, additional, Covello, Giuseppe, additional, Torresin, Tommaso, additional, Midena, Giulia, additional, Danieli, Luca, additional, Pilotto, Elisabetta, additional, Figus, Michele, additional, Mariotti, Cesare, additional, and Lupidi, Marco, additional

Published
2023
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48. Randomized Phase IIb Study of Brimonidine Drug Delivery System Generation 2 for Geographic Atrophy in Age-Related Macular Degeneration

Author

Freeman, William R., primary, Bandello, Francesco, additional, Souied, Eric, additional, Guymer, Robyn H., additional, Garg, Sunir J., additional, Chen, Fred K., additional, Rich, Ryan, additional, Holz, Frank G., additional, Patel, Sunil S., additional, Kim, Kimmie, additional, López, Francisco J., additional, Chen, Fred, additional, Guymer, Robyn, additional, Korobelnik, Jean-Francois, additional, Holz, Frank, additional, Ziemssen, Focke, additional, Campos, Emilio, additional, Grignolo/Eandi, Chiara, additional, Midena, Edoardo, additional, Peiretti, Enrico, additional, Staurenghi, Giovanni, additional, Viola, Francesco, additional, Bailey, Clare, additional, Esposti, Simona Degli, additional, Jackson, Timothy, additional, Menon, Geeta, additional, Pagliarini, Sergio, additional, Quhill, Fahd, additional, Antoszyk, Andrew, additional, Brooks, Logan, additional, Callanan, David, additional, Csaky, Karl, additional, Edwards, Albert, additional, Eichenbaum, David, additional, Freeman, William, additional, Garg, Sunir, additional, Ghuman, Avtar Thomas, additional, Gonzalez, Victor, additional, Gupta, Sunil, additional, Hamilton, Richard, additional, Khurana, Rahul, additional, Kunimoto, Derek, additional, Kuppermann, Baruch, additional, Lauer, Andreas, additional, Lee, Seong Young, additional, Maturi, Raj, additional, Patel, Sunil, additional, Reddy, Rahul, additional, Rivellese, Mark, additional, Rose, Steven, additional, Segal, Zachary, additional, and Wong, Robert, additional

Published
2023
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