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1. Refractive Growth of the Crystalline Lens in the Infant Aphakia Treatment Study

Author

Thaddeus S. McClatchey, MD, Scott R. Lambert, MD, David G. Morrison, MD, Stacey J. Kruger, MD, Lorri B. Wilson, MD, Scott K. McClatchey, MD, Scott R. Lambert, MD (Study Chair), Lindreth DuBois, MEd, MMSc, CO, COMT (National Coordinator), Azhar Nizam, MS (Director), Qi Long, PhD (former Director), Michael J. Lynn, MS (former Director), Betsy Bridgman, BS, Marianne Celano, PhD, Julia Cleveland, MS, George Cotsonis, MS, Carey Drews-Botsch, PhD, Nana Freret, MSN, Lu Lu, MS, Seegar Swanson, Thandeka Tutu-Gxashe, MPH, E. Eugenie Hartmann, PhD (Director), Anna K. Carrigan, MPH, Clara Edwards, Claudio Busettini, PhD, Samuel Hayley, Eleanor Lewis, Alicia Kindred Joost Felius, PhD, Edward G. Buckley, MD, David A. Plager, MD, M. Edward Wilson, MD, Lindreth DuBois, MEd, MMSc, Carolyn Drews-Botsch, PhD, E. Eugenie Hartmann, PhD, Donald F. Everett, MA, Michael J. Lynn, MS, Qi Long, PhD, Azhar Nizam, MS, Joost Felius, PhD, Margaret Bozic, CCRC, COA, Ann Holleschau, BA, Buddy Russell, COMT, Michael Ward, Carol Bradham, COA, Deborah K. Vanderveen, MD, Theresa A. Mansfield, RN, Kathryn Bisceglia Miller, OD, Tamar Winter, RN, Stephen P. Christiansen, MD, Erick D. Bothun, MD, Jason Jedlicka, OD, Patricia Winters, OD, Jacob Lang, OD, Jill S. Anderson, MD, Elias I. Traboulsi, MD, Susan Crowe, BS, COT, Heather Hasley Cimino, OD, Faruk Orge, MD, Megin Kwiatkowski, Beth Colon, Angela Meador, COA, MHA, Kimberly G. Yen, MD, Maria Castanes, MPH, Alma Sanchez, COA, Shirley York, OD, Stacy Malone, COA, Margaret Olfson, Gihan Romany, MBChB, COMT, CCRC, David T. Wheeler, MD, Ann U. Stout, MD, Paula Rauch, OT, CRC, Kimberly Beaudet, CO, COMT, Pam Berg, CO, COMT, Lorri Wilson, MD, Amy K. Hutchinson, MD, Lindreth Dubois, MEd, MMSc, CO, COMT, Rachel Robb, MMSc, CO, COMT, Marla J. Shainberg, CO, Sharon F. Freedman, MD, Lois Duncan, BS, CO, COMT, B.W. Phillips, FCLSA, John T. Petrowski, OD, Sarah Jones, MS, David Morrison, MD, Sandy Owings, COA, CCRP, Ron Biernacki, CO, COMT, Christine Franklin, COT, Scott Ruark, Daniel E. Neely, MD, Michele Whitaker, COMT, CCRP, Donna Bates, COA, Dana Donaldson, OD, Stacey Kruger, MD, Charlotte Tibi, CO, Susan Vega, David R. Weakley, MD, David R. Stager, Jr., M.D., Clare Dias, CO, Debra L. Sager, Todd Brantley, OD, Bonnie Miller, PhD, Eva Lutz, CO, Lisa Davis, Robert Hardy, PHD (Chair), Eileen Birch, PhD, Ken Cheng, MD, Richard Hertle, MD, Craig Kollman, PhD, Marshalyn Yeargin-Allsopp, MD (resigned), Cyd McDowell, and Allen Beck, MD

Subjects
IATS, Ocular development, Pediatric cataract surgery, RRG3, Ophthalmology, RE1-994
Abstract

Objective: To compare the rate of refractive growth (RRG3) of the crystalline lens (“lens”) versus the eye excluding the lens (“globe”) for the fellow, noncataractous eyes of participants in the Infant Aphakia Treatment Study. Design: Retrospective cohort study. Subjects: A total of 114 children who had unilateral cataract surgery as infants were recruited. Biometric and refraction data were obtained from the normal eyes at surgery and at 1, 5, and 10 years. Subjects were included if complete data (axial length [AL], corneal power, and refraction) were available at surgery and at 10 years of age. Methods: At surgery and at 1, 5, and 10 years, AL, corneal power, and cycloplegic refraction were measured in the normal eyes. For each eye, the RRG3 was defined by linear regression of refraction at the intraocular lens (IOL) plane against log10 (age + 0.6 years). The RRG3 for the globe was based on IOL power for emmetropia; the RRG3 for the lens was based on IOL power calculated to give the observed refractions. Intraocular lens powers were calculated with the Holladay 1 formula. The means were compared with a paired 2-tailed t test, and linear regression was used to look for a correlation between RRG3 of the lens globe. Main Outcome Measures: The RRG3 of the lens and globe. Results: Complete data were available for 107 normal eyes. The mean RRG3 of the lenses was −12.0 ± 2.5 diopters (D) and the mean RRG3 of the globes was −14.1 ± 2.7 D (P < 0.001). The RRG3 of the lens correlated with the RRG3 of the globe (R2 = 0.25, P < 0.001). Conclusions: The RRG3 was 2 D more negative in globes compared with lenses in normal eyes. Globes with a greater rate of growth tended to have lenses with a greater rate of growth.

Published
2022
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2. Myopic Shift at 10-Year Follow-up in the Infant Aphakia Treatment Study

Author

David R. Weakley, Azhar Nizam, Deborah K. VanderVeen, M. Edward Wilson, Stacy Kruger, Scott R. Lambert, Lindreth DuBois, Buddy Russell, Michael Ward, Robert Hardy, Eileen Birch, Ken Cheng, Richard Hertle, Craig Kollman, Marshalyn Yeargin-Allsopp, Cyd McDowell, Donald F. Everett, Qi Long, Michael Lynn, Betsy Bridgman, Marianne Celano, Julia Cleveland, George Cotsonis, Nana Freret, Lu Lu, Neeta Shenvi, Seegar Swanson, Thandeka Tutu-Gxashe, Carey Drews-Botsch, Claudio Busettini, Samuel Hayley, Joost Felius, Allen Beck, Edward G. Buckley, David A. Plager, Carolyn Drews-Botsch, E. Eugenie Hartmann, Eugenie Hartmann, Anna K. Carrigan, Clara Edwards, Margaret Bozic, Theresa A. Mansfield, Kathryn Bisceglia Miller, Stephen P. Christiansen, Erick D. Bothun, Ann Holleschau, Jason Jedlicka, Patricia Winters, Jacob Lang, Elias I. Traboulsi, Susan Crowe, Heather Hasley Cimino, Kimberly G. Yen, Maria Castanes, Alma Sanchez, Shirley York, Amy K. Hutchinson, Lindreth Dubois, Rachel Robb, Marla J. Shainberg, David T. Wheeler, Ann U. Stout, Paula Rauch, Kimberly Beaudet, Pam Berg, Sharon F. Freedman, Lois Duncan, B.W. Phillips, John T. Petrowski, David Morrison, Sandy Owings, Ron Biernacki, Christine Franklin, Daniel E. Neely, Michele Whitaker, Donna Bates, Dana Donaldson, Charlotte Tibi, Susan Vega, David R. Stager, Clare Dias, Debra L. Sager, Todd Brantley, and Faruk Orge

Subjects
Ophthalmology, Myopia, Humans, Infant, Aphakia, Postcataract, Cataract Extraction, Aphakia, Follow-Up Studies
Published
2021

3. Stereopsis results at 4.5 years of age in the infant aphakia treatment study

Author

E. Eugenie Hartmann, Ann U. Stout, Michael J. Lynn, Kimberly G. Yen, Stacey J. Kruger, Scott R. Lambert, Lindreth DuBois, Michael Lynn, Betsy Bridgman, Marianne Celano, Julia Cleveland, George Cotsonis, Carey Drews-Botsch, Nana Freret, Lu Lu, Seegar Swanson, Thandeka Tutu-Gxashe, Anna K. Carrigan, Clara Edwards, Claudio Busettini, Samuel Hayley, Eleanor Lewis, Alicia Kindred, Joost Felius, Edward G. Buckley, David A. Plager, M. Edward Wilson, Carolyn Drews-Botsch, Donald F. Everett, Margaret Bozic, Ann Holleschau, Buddy Russell, Michael Ward, Carol Bradham, Deborah K. Vanderveen, Theresa A. Mansfield, Kathryn Bisceglia Miller, Stephen P. Christiansen, Erick D. Bothun, Jason Jedlicka, Patricia Winters, Jacob Lang, Elias I. Traboulsi, Susan Crowe, Heather Hasley Cimino, Faruk Orge, Megin Kwiatkowski, Beth Colon, Maria Castanes, Alma Sanchez, Shirley York, Stacy Malone, Margaret Olfson, David T. Wheeler, Paula Rauch, Kimberly Beaudet, Pam Berg, Amy K. Hutchinson, Rachel Robb, Marla J. Shainberg, Sharon F. Freedman, Lois Duncan, B.W. Phillips, John T. Petrowski, David Morrison, Sandy Owings, Ron Biernacki, Christine Franklin, Daniel E. Neely, Michele Whitaker, Donna Bates, Dana Donaldson, Stacey Kruger, Charlotte Tibi, Susan Vega, David R. Weakley, David R. Stager, Clare Dias, Debra L. Sager, Todd Brantley, Robert Hardy, Eileen Birch, Ken Cheng, Richard Hertle, Craig Kollman, Marshalyn Yeargin-Allsopp, Cyd McDowell, and Allen Beck

Subjects
Male, medicine.medical_specialty, Visual acuity, genetic structures, Contact Lenses, medicine.medical_treatment, Visual Acuity, Intraocular lens, Aphakia, Article, law.invention, Cataracts, Randomized controlled trial, Lens Implantation, Intraocular, law, Ophthalmology, medicine, Humans, Prospective Studies, Prospective cohort study, Depth Perception, business.industry, medicine.disease, eye diseases, Contact lens, Stereopsis, Child, Preschool, Multivariate Analysis, Female, sense organs, medicine.symptom, business
Abstract

Purpose To determine whether stereopsis of infants treated for monocular cataracts varies with the type of optical correction used. Design Randomized prospective clinical trial. Methods The Infant Aphakia Treatment Study randomized 114 patients with unilateral cataracts at age 1–7 months to either primary intraocular lens (IOL) or contact lens correction. At 4.5 years of age a masked examiner assessed stereopsis on these patients using 3 different tests: (1) Frisby; (2) Randot Preschool; and (3) Titmus Fly. Results Twenty-eight patients (25%) had a positive response to at least 1 of the stereopsis tests. There was no statistically significant difference in stereopsis between the 2 treatment groups: Frisby (contact lens, 6 [11%]; IOL, 7 [13%]; P = .99), Randot (contact lens, 3 [6%]; IOL, 1 [2%]; P = .62), or Titmus (contact lens, 8 [15%]; IOL, 13 [23%]; P = .34). The median age at surgery for patients with stereopsis was younger than for those without stereopsis (1.2 vs 2.4 months; P = .002). The median visual acuity for patients with stereopsis was better than for those without stereopsis (20/40 vs 20/252; P = .0003). Conclusion The type of optical correction did not influence stereopsis outcomes. However, 2 other factors did: age at surgery and visual acuity in the treated eye at age 4.5 years. Early surgery for unilateral congenital cataract and the presence of visual acuity better than or equal to 20/40 appear to be more important than the type of initial optical correction used for the development of stereopsis.

Published
2014

4. The infant aphakia treatment study: design and clinical measures at enrollment

Author

Lois Duncan, Marianne Celano, Theresa A. Mansfield, Michael J. Lynn, Ann U. Stout, E. Eugenie Hartmann, Rachel Reeves, Daniel E. Neely, Lindreth DuBois, Donna Bates, Heather Hasley Cimino, Elias I. Traboulsi, Julia Cleveland, Alma Sanchez, Betsy Bridgman, Paula Rauch, Susan Vega, Debra L. Sager, Marshalyn Yeargin-Allsopp, George Cotsonis, Scott R. Lambert, Thandeka Tutu-Gxashe, Joost Felius, Dana Donaldson, Deborah K. VanderVeen, Edward G. Buckley, Shirley York, M. Edward Wilson, Ann M. Holleschau, David T. Wheeler, Marla J. Shainberg, Maria Castanes, Sharon F. Freedman, Amy K. Hutchinson, Claudio Busettini, Carolyn Drews-Botsch, Clare Dias, Margaret Bozic, Kimberly Beaudet, Patricia Winters, Craig Kollman, Sandy Owings, David R. Weakley, Nana Freret, Todd Brantley, Robert J. Hardy, B.W. Phillips, Lu Lu, Kimberly G. Yen, Michael A. Ward, Buddy Russell, Clara Edwards, Donald F. Everett, Charlotte Tibi, Erick D. Bothun, Jason Jedlicka, Stacey J. Kruger, David R. Stager, Richard W. Hertle, Kenneth P. Cheng, Cindy Bachman, Susan Crowe, David A. Plager, Pam Berg, Eileen E. Birch, Michele Whitaker, Ron Biernacki, Kathryn Bisceglia Miller, Stephen P. Christiansen, Seegar Swanson, John T. Petrowski, David G. Morrison, Allen D. Beck, Christine Franklin, and Samuel Hayley

Subjects
Male, medicine.medical_specialty, Refractive error, Visual acuity, genetic structures, Eye Movements, Pseudophakia, Contact Lenses, medicine.medical_treatment, Visual Acuity, Aphakia, Postcataract, Cataract Extraction, Aphakia, Cataract, Article, law.invention, Randomized controlled trial, Cataracts, Lens Implantation, Intraocular, law, Ophthalmology, medicine, Humans, business.industry, Infant, Cataract surgery, medicine.disease, Refractive Errors, eye diseases, Surgery, Contact lens, Eyeglasses, Treatment Outcome, Research Design, Congenital cataracts, Female, sense organs, medicine.symptom, business, Follow-Up Studies
Abstract

Objective To compare the use of contact lenses and intraocular lenses (IOLs) for the optical correction of unilateral aphakia during infancy. Methods In a randomized, multicenter (12 sites) clinical trial, 114 infants with unilateral congenital cataracts were assigned to undergo cataract surgery with or without IOL implantation. Children randomized to IOL treatment had their residual refractive error corrected with spectacles. Children randomized to no IOL treatment had their aphakia treated with a contact lens. Main outcome measures Grating acuity at 12 months of age and HOTV visual acuity at 4 1/2 years of age. Application to clinical practice This study should determine whether either treatment for an infant with a visually significant unilateral congenital cataract results in a better visual outcome. Results Enrollment began December 23, 2004, and was completed January 16, 2009. The median age at the time of cataract surgery was 1.8 months. Fifty patients were 4 to 6 weeks of age at the time of enrollment; 32, 7 weeks to 3 months of age; and the remaining 32, more than 3 to less than 7 months of age. Fifty-seven children were randomized to each treatment group. Eyes with cataracts had shorter axial lengths and steeper corneas on average than the fellow eyes. Conclusions The optimal optical treatment of aphakia in infants is unknown. However, the Infant Aphakia Treatment Study was designed to provide empirical evidence of whether optical treatment with an IOL or a contact lens after unilateral cataract surgery during infancy is associated with a better visual outcome.

Published
2010

5. Evaluation of the Intermittent Exotropia Questionnaire Using Rasch Analysis

Author

Daniel J. Karr, Michelle Bass, Rebecca Dent, Richard London, Laura B. Enyedi, Annette Bade, Wanda Pfeifer, Aaron M. Miller, Matthew D. Gearinger, B. Michele Melia, Monica Pacheco, Susan A. Cotter, Heather A Anderson, Heather Klem, Kenneth Adams, Joan Roberts, Donny W. Suh, Tammy Price, Sergul Erzurum, Ruth E. Manny, Ronald G.W. Teed, Peter Macdowell, Elise Harb, Melanie Christian, Reena Patel, Ann U. Stout, Troy Kieser, Raymond H. Chu, Anesu Mvududu, Vivian Wong, Tawna L Roberts, Angela Chen, Tamara S Oechslin, Richard L. Weaver, Michele Whitaker, Paula Rauch, Nancy Stevens, Elias I. Traboulsi, Karen Pollack, Noelle S. Matta, Robert P. Rutstein, Cheryl Capobianco, Paul G. Steinkuller, Gaylord Ventura, Carol Bradham, Mei Mellott, Darren L. Hoover, Jacqueline Rodena, Heidi Martin, Brian J. Forbes, Jill S. Anderson, Mary Louise Z. Collins, Robert Peters, Gil Binenbaum, Stephen P. Christiansen, Jayne Silver, Phoebe D. Lenhart, Marcela Frazier, Yasmin S. Bradfield, Kimberly G. Yen, Sara Meeder, Eileen Dittman, Lisa Fraine, Emi Sanders, Don Lyon, Nandini G. Gandhi, Wendy Marsh-Tootle, Pamela A. Huston, Ilana B Friedman, Lori Cooke, Beth Colon, Jonathan M. Holmes, Shelley Klein, Rosanne Superstein, Susannah Q. Longmuir, Sarah R. Hatt, Joan Do, Carmen Barnhardt, William F. Astle, Daniel E. Neely, Robert Duckman, Benjamin H. Ticho, Dipali Dave, Susanna M. Tamkins, Vanessa Vazquez, Rebecca Nielsen, Marilyn Vricella, Lernik Mesropian, Robert L. Estes, Gregory Ostrow, Laura Kirkeby, David G. Morrison, Andrew J. Toole, Nicole Fallaha, Paul J. Rychwalski, Kristy Dunlap, Susan Parker, Jeanine Romeo, David K. Wallace, Aaliyah Hamidullah, Edward Cheeseman, Mitchell Scheiman, David A. Leske, Caroline Belanger, Diana McOwen, Brian W. Arthur, Hee Jung Park, David I. Silbert, Tammy L. Yanovitch, David B. Petersen, Alex Christoff, Lesley Macsween, Sean P. Donahue, Xiaonong Liu, Eric Hein, David Robbins Tien, Lori Ann F. Kehler, Evelyn Koestenblatt, Indre M. Rudaitis, Jan Hilbrands, Sarah K. Jones, C. Gail Summers, Catherine Heyman, Jennifer Brady, Maynard Wheeler, Katherine K. Weise, Jorie Jackson, Ann M. Holleschau, Allison I. Summers, Kenneth Romanchuk, Megan Allen, Christie L. Morse, Inge De Becker, Sarah Downes, Tomohiko Yamada, Mitchell B. Strominger, Brian G. Mohney, David K. Coats, Susan Hayes, Freda Dallas, Amy K. Hutchinson, Deborah Clausius, Maryse Thibeault, Stacy L. Pineles, Lingkun Kong, Airaj Fasiuddin, Jeffery Colburn, Paula Handford, Blair Spencer, Tamiesha Frempong, Mae Millicent W. Peterseim, Hawke Yoon, Angela Alfaro, Catherine McDaniel, Jean E. Ramsey, Laura Liebermann, Laura Graham, Karen A. Karp, Stephen Van Iderstine, Earl R. Crouch, Evelyn A. Paysse, Alexander Khammar, Patricia L. Davis, J. McMurtrey, Bahram Rahmani, Judy Brower, Todd Goldblum, Yana Kiesau, Stephen R. Glaser, Scott R. Lambert, Karen D. Fern, Tara Cronin, Justin Smith, Maureen Flanagan, Marjean Taylor Kulp, Susan Crowe, Allison Jensen, Michael X. Repka, Adriana P. Grigorian, Nausheen Khuddus, Michael Bartiss, Ross Roegner, Faruk Ogre, Erick D. Bothun, Kristine Huang, Erin Herlihy, Daniel M. Laby, Mary A O'Hara, Tennille McGaw, Nicholas A. Sala, Samantha Garner, Mohamed A.W. Hussein, Barbara Soderling, Marianne Esguerra, and Yi Pang

Subjects
Male, medicine.medical_specialty, Adolescent, Cross-sectional study, Health Status, Article, Proxy (climate), Sickness Impact Profile, Surveys and Questionnaires, Humans, Medicine, Child, Rasch model, business.industry, Infant, Reproducibility of Results, medicine.disease, Ophthalmology, Cross-Sectional Studies, Child, Preschool, Cohort, Quality of Life, Physical therapy, Exotropia, Female, business, Intermittent exotropia, Psychosocial, Cohort study
Abstract

Importance The Intermittent Exotropia Questionnaire (IXTQ) is a patient, proxy, and parental report of quality of life specific to children with intermittent exotropia. We refine the IXTQ using Rasch analysis to improve reliability and validity. Observation Rasch analysis was performed on responses of 575 patients with intermittent exotropia enrolled from May 15, 2008, through July 24, 2013, and their parents from each of the 4 IXTQ health-related quality-of-life questionnaires (child 5 through 7 years of age and child 8 through 17 years of age, proxy, and parent questionnaires). Questionnaire performance and structure were confirmed in a separate cohort of 379 patients with intermittent exotropia. One item was removed from the 12-item child and proxy questionnaires, and response options in the 8- to 17-year-old child IXTQ and proxy IXTQ were combined into 3 response options for both questionnaires. Targeting was relatively poor for the child and proxy questionnaires. For the parent questionnaire, 3 subscales (psychosocial, function, and surgery) were evident. One item was removed from the psychosocial subscale. Resulting subscales had appropriate targeting. Conclusions and Relevance The Rasch-revised IXTQ may be a useful instrument for determining how intermittent exotropia affects health-related quality of life of children with intermittent exotropia and their parents, particularly for cohort studies.

Published
2015
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6. A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children

Author

David A. Plager, Lourdes Asiain, Viviana Correodor, Bradley V. Davitt, Derek T. Sprunger, Dorothy B. Conlan, David Robbins Tien, Alexander T. Elliott, Julie A. Ozier, Emily A. Miyazaki, Yvonne F. Flores, John H. Lee, Mary Diane Armitage, Sherene C. Fort, Mark S. Ruttum, Jana S. Mattheu, Andrew J. Levada, Mary S. McAlester, Jay Galli, Robert P. Rutstein, Susan M. Shin, Michele A. Hartwell, Ronald J. Biernacki, Eileen E. Birch, Roy W. Beck, Jaime N. Brown, Cathy H. Baldwin, Michele Whitaker, Heather M. Vibert, Jennifer L. Slutsky, Heidi C. Christ, Lauren B. DeWaele, Nicole Fallaha, Mary Louise Z. Collins, Tracy D. Louie, Catriona I. Kerr, Guy E. Foster, Susanna M. Tamkins, Heather J. Peddie, David K. Coats, Siby Jacobs, Daniel E. Neely, Jane D. Kivlin, Carole R. Goodman, Donna Bates, Stephen R. Glaser, Michael X. Repka, Susan A. Cotter, Joost Felius, Nancy H. Brusseau, Anna R. O'Connor, Veronica R. Picard, Evelyn Tomlinson, Priscilla M. Berry, Sue Ann Parrish, Sheena O. Broome, Merelyn J. Chesner, Kathryn M. Brady-McCreery, David G. Hunter, Richard W. Hertle, Cheryl R. Hayduk, Kimberley A. Beaudet, Chrissy M. Vroman, David M. Sclar, Carmen Barnhardt, William F. Astle, David Young, Lucy L.H. Yang, Dipti Desai, Christin L. Bateman, Cindy E. Tanner, Sean P. Donahue, Ed J. Fitzgibbon, Cindy Foss, Cheryl L. McCarus, Scott R. Lambert, Gen Lee, Susan A. Havertape, Brett G. Jeffrey, David R. Stager, James B. Ruben, Nicholas A. Sala, Susan D. Mellow, Alma Sanchez, Jennifer A. Wilkerson, Kristine T. Becker, Anna L. Ells, David T. Wheeler, Michele Gonzalez, Molly B. Bosch, Raymond H. Chu, Andrea M. Matazinski, Evelyn A. Paysse, Robert W Arnold, Maria Petrova Pesheva, Glenn E. Bulan, Wendy Marsh-Tootle, and Oscar A. Cruz

Subjects
Atropine, Male, Mydriatics, business.industry, Visual Acuity, Amblyopia, law.invention, Ophthalmology, Treatment Outcome, Randomized controlled trial, law, Anesthesia, Occlusion therapy, Child, Preschool, medicine, Humans, Patient Compliance, Female, Ophthalmic Solutions, Sensory Deprivation, business, Child, medicine.drug, Follow-Up Studies
Abstract

To compare patching and atropine as treatments for moderate amblyopia in children younger than 7 years.In a randomized clinical trial, 419 children younger than 7 years with amblyopia and visual acuity in the range of 20/40 to 20/100 were assigned to receive either patching or atropine at 47 clinical sites.Visual acuity in the amblyopic eye and sound eye after 6 months.Visual acuity in the amblyopic eye improved in both groups (improvement from baseline to 6 months was 3.16 lines in the patching group and 2.84 lines in the atropine group). Improvement was initially faster in the patching group, but after 6 months, the difference in visual acuity between treatment groups was small and clinically inconsequential (mean difference at 6 months, 0.034 logMAR units; 95% confidence interval, 0.005-0.064 logMAR units). The 6-month acuity was 20/30 or better in the amblyopic eye and/or improved from baseline by 3 or more lines in 79% of the patching group and 74% of the atropine group. Both treatments were well tolerated, although atropine had a slightly higher degree of acceptability on a parental questionnaire. More patients in the atropine group than in the patching group had reduced acuity in the sound eye at 6 months, but this did not persist with further follow-up.Atropine and patching produce improvement of similar magnitude, and both are appropriate modalities for the initial treatment of moderate amblyopia in children aged 3 to less than 7 years.

Published
2002

7. Complications in the First 5 Years Following Cataract Surgery in Infants With and Without Intraocular Lens Implantation in the Infant Aphakia Treatment Study

Author

David A. Plager, Michael J. Lynn, Edward G. Buckley, M. Edward Wilson, Scott R. Lambert, Lindreth DuBois, Michael Lynn, Carolyn Drews-Botsch, E. Eugenie Hartmann, Donald F. Everett, Buddy Russell, Michael Ward, Robert Hardy, Eileen Birch, Ken Cheng, Richard Hertle, Craig Kollman, Marshalyn Yeargin-Allsopp, Cyd McDowell, Betsy Bridgman, Marianne Celano, Julia Cleveland, George Cotsonis, Carey Drews-Botsch, Nana Freret, Lu Lu, Seegar Swanson, Thandeka Tutu-Gxashe, Claudio Busettini, Samuel Hayley, Joost Felius, Allen Beck, Anna K. Carrigan, Clara Edwards, Margaret Bozic, Deborah K. Vanderveen, Theresa A. Mansfield, Kathryn Bisceglia Miller, Stephen P. Christiansen, Erick D. Bothun, Ann Holleschau, Jason Jedlicka, Patricia Winters, Jacob Lang, Elias I. Traboulsi, Susan Crowe, Heather Hasley Cimino, Kimberly G. Yen, Maria Castanes, Alma Sanchez, Shirley York, Amy K. Hutchinson, Lindreth Dubois, Rachel Robb, Marla J. Shainberg, David T. Wheeler, Ann U. Stout, Paula Rauch, Kimberly Beaudet, Pam Berg, Sharon F. Freedman, Lois Duncan, B.W. Phillips, John T. Petrowski, David Morrison, Sandy Owings, Ron Biernacki, Christine Franklin, Daniel E. Neely, Michele Whitaker, Donna Bates, Dana Donaldson, Stacey Kruger, Charlotte Tibi, Susan Vega, David R. Weakley, David R. Stager, Clare Dias, Debra L. Sager, Todd Brantley, and Faruk Orge

Subjects
medicine.medical_specialty, Visual acuity, genetic structures, business.industry, medicine.medical_treatment, Intraocular lens, Cataract surgery, medicine.disease, Aphakia, Article, eye diseases, law.invention, Surgery, Contact lens, Ophthalmology, Randomized controlled trial, law, Anesthesia, Medicine, sense organs, medicine.symptom, business, Prospective cohort study, Adverse effect
Abstract

Purpose To compare rates and severity of complications between infants undergoing cataract surgery with and without intraocular lens (IOL) implantation. Design Prospective randomized clinical trial. Methods A total of 114 infants were enrolled in the Infant Aphakia Treatment Study, a randomized, multi-center (12) clinical trial comparing the treatment of unilateral aphakia in patients under 7 months of age with a primary IOL implant or contact lens. The rate, character, and severity of intraoperative complications, adverse events, and additional intraocular surgeries during the first 5 postoperative years in the 2 groups were examined. Results There were more patients with intraoperative complications (28% vs 11%, P = .031), adverse events (81% vs 56%, P = .008), and more additional intraocular surgeries (72% vs 16%, P Conclusion The increased rate of complications, adverse events, and additional intraocular surgeries associated with IOL implantation in infants

Published
2014
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