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The infant aphakia treatment study: design and clinical measures at enrollment
- Source :
- Archives of ophthalmology (Chicago, Ill. : 1960). 128(1)
- Publication Year :
- 2010
-
Abstract
- Objective To compare the use of contact lenses and intraocular lenses (IOLs) for the optical correction of unilateral aphakia during infancy. Methods In a randomized, multicenter (12 sites) clinical trial, 114 infants with unilateral congenital cataracts were assigned to undergo cataract surgery with or without IOL implantation. Children randomized to IOL treatment had their residual refractive error corrected with spectacles. Children randomized to no IOL treatment had their aphakia treated with a contact lens. Main outcome measures Grating acuity at 12 months of age and HOTV visual acuity at 4 1/2 years of age. Application to clinical practice This study should determine whether either treatment for an infant with a visually significant unilateral congenital cataract results in a better visual outcome. Results Enrollment began December 23, 2004, and was completed January 16, 2009. The median age at the time of cataract surgery was 1.8 months. Fifty patients were 4 to 6 weeks of age at the time of enrollment; 32, 7 weeks to 3 months of age; and the remaining 32, more than 3 to less than 7 months of age. Fifty-seven children were randomized to each treatment group. Eyes with cataracts had shorter axial lengths and steeper corneas on average than the fellow eyes. Conclusions The optimal optical treatment of aphakia in infants is unknown. However, the Infant Aphakia Treatment Study was designed to provide empirical evidence of whether optical treatment with an IOL or a contact lens after unilateral cataract surgery during infancy is associated with a better visual outcome.
- Subjects :
- Male
medicine.medical_specialty
Refractive error
Visual acuity
genetic structures
Eye Movements
Pseudophakia
Contact Lenses
medicine.medical_treatment
Visual Acuity
Aphakia, Postcataract
Cataract Extraction
Aphakia
Cataract
Article
law.invention
Randomized controlled trial
Cataracts
Lens Implantation, Intraocular
law
Ophthalmology
medicine
Humans
business.industry
Infant
Cataract surgery
medicine.disease
Refractive Errors
eye diseases
Surgery
Contact lens
Eyeglasses
Treatment Outcome
Research Design
Congenital cataracts
Female
sense organs
medicine.symptom
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15383601
- Volume :
- 128
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Archives of ophthalmology (Chicago, Ill. : 1960)
- Accession number :
- edsair.doi.dedup.....fa4db11956f54aa42249c59a76d5af86