10 results on '"Michal Sheinis"'
Search Results
2. The Quality and Quantity of Lower Genital Tract Research Across Multiple Journals
- Author
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Michal Sheinis, Megan Macfarlane, and Amanda Selk
- Subjects
Obstetrics ,Pregnancy ,Gynecology ,Obstetrics and Gynecology ,Humans ,Female ,General Medicine ,Genitalia ,Periodicals as Topic ,Systematic Reviews as Topic - Abstract
This study aimed to determine the quantity and quality of lower genital tract disease (LGTD) research by topic published across a variety of gynecology and dermatology journals.Authors accessed all articles that were rejected (1,111, 59.5%) and accepted (755, 40.5%) by the Journal of Lower Genital Tract Disease ( JLGTD ) from 2008 to 2020. Studies were categorized by key topic: Cervix, Human Papillomavirus, Vulva, Vagina, Anal, and Other. Studies were further subcategorized based on methodology. These data were compared with all LGTD publications from 2018 to 2020 in 4 other widely recognized journals ( Obstetrics and Gynecology , The British Journal of Obstetrics and Gynaecology , JAMA Dermatology , and the British Journal of Dermatology ).Most JLGTD -accepted submissions were related to the cervix (298/755, 39.5%) and vulva (189/755, 25.0%). Rates of acceptance were similar across all key topic areas. Only 3.2% of publications in the other 4 journals (92/2,932) were related to LGTD topics. Across all 5 journals, vulva studies were most commonly case reports/case series (82/218, 37.6%), with a low prevalence of systematic reviews/meta-analyses (4/218 1.8%). In comparison, cervix studies had the highest number of systematic reviews/meta-analyses (14/317, 4.4%) and the lowest number of case reports (14/317, 4.4%).Vulvar research is of lower quality compared with cervix research published across 5 journals. Comparing accepted versus rejected articles in JLGTD , there is no publication bias against vulva topics noted; rather, the overall research quality in vulva is lower than that of cervical disease. This is a call to action for higher quality vulvar research.
- Published
- 2022
3. Vulvar Lichen Sclerosus: Outcomes Important to Patients in Assessing Disease Severity
- Author
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Michal Sheinis, Nicole Green, and Amanda Selk
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Labia ,Physical examination ,Disease ,medicine.disease_cause ,Severity of Illness Index ,Vulvar Lichen Sclerosus ,Vulva ,Young Adult ,03 medical and health sciences ,Severity assessment ,0302 clinical medicine ,Quality of life ,Disease severity ,Surveys and Questionnaires ,medicine ,Humans ,Aged ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Physical therapy ,Female ,Irritation ,business - Abstract
OBJECTIVE The aim of the study was to determine outcome measures that women with vulvar lichen sclerosus (LS) rate as important in assessing disease severity with the ultimate goal of including these items in a disease severity rating tool. METHODS An online survey of women older than 18 years with a diagnosis of vulvar LS was performed. The survey was posted in Facebook LS support groups. Participants rated items on a scale from 1 to 5 (not important to include to essential to include) in a disease severity scale. Participants also rated how often they were affected by various symptoms on a scale from 1 to 5 (never to daily). Mean rating of importance and mean rating of frequency for each sign and symptom were calculated. T tests were used to compare patients with biopsy-proven disease with those with a clinical diagnosis of LS. RESULTS Nine hundred fifty-eight participants completed the survey (86% completion rate). Patients felt that the most important items to assess disease severity were irritation (4.39), fusion of the labia (4.38), soreness (4.37), itch (4.34), change in vulvar skin (4.34), and decrease in quality of life (4.33). The most frequently experienced items by those with LS were irritation (3.92), changes in appearance of vulvar skin (3.92), and discomfort (3.89). There were no differences between patients with biopsy-proven LS versus those diagnosed on clinical examination. CONCLUSIONS Future LS severity assessment tools will need to include a combination of patient-rated symptoms, clinical rated signs and anatomical changes, and quality of life measures.
- Published
- 2020
4. Documentation of Consent Practices for Assisted Vaginal Births (AVB) at Two Tertiary Care Hospitals: A Retrospective Review of Physician Documentation
- Author
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Michal Sheinis, Jane Zhu, Sebastian Hobson, Rajiv Shah, Jodi Shapiro, and Lindsay Shirreff
- Subjects
Obstetrics and Gynecology - Published
- 2022
5. Patients’ Knowledge of Prenatal Screening for Trisomy 21
- Author
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Michal Sheinis, Kira Bensimon, and Amanda Selk
- Subjects
Adult ,Canada ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,Pediatrics ,Genetic counseling ,Trisomy ,Health literacy ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Informed consent ,Prenatal Diagnosis ,Surveys and Questionnaires ,Health care ,Humans ,Medicine ,030212 general & internal medicine ,Genetics (clinical) ,Screening procedures ,Informed Consent ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics ,Public health ,medicine.disease ,Health Literacy ,Cross-Sectional Studies ,Female ,Down Syndrome ,business ,Patient education - Abstract
This study's objective was to assess the knowledge of prenatal screening for Trisomy 21 in pregnant women in one institution in Canada. A cross-sectional survey measuring demographics, knowledge of screening, and health literacy, was administered to pregnant women. Of the 135 women who completed the survey, 74% had adequate knowledge of Trisomy 21 and associated screening procedures. Twenty-eight point one percent of women did not receive any counseling. Overall, 29.5% of women did not know that the screening test was optional and 10.2% of women underwent screening prior to having been counseled. Multigravidity (p < 0.05) and prior counseling (p < 0.001) were positively correlated with knowledge while first language other than English (p < 0.001) was negatively correlated with knowledge. Given these findings, an effort needs to be made on the part of health care providers to increase counseling rates to 100%, stressing the optional nature of the test to attain true informed consent.
- Published
- 2017
6. Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome
- Author
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Grant W. Brown, Samuel Benchimol, Weili Ma, Brandon Ho, Keith Wheaton, Denise Campuzano, and Michal Sheinis
- Subjects
DNA Replication ,0301 basic medicine ,Senescence ,congenital, hereditary, and neonatal diseases and abnormalities ,DNA damage ,Biology ,LMNA ,03 medical and health sciences ,Progeria ,medicine ,Humans ,Protein Precursors ,Telomerase ,Molecular Biology ,Cellular Senescence ,integumentary system ,DNA replication ,nutritional and metabolic diseases ,Cell Biology ,Fibroblasts ,Telomere ,Lamin Type A ,medicine.disease ,Progerin ,Cell biology ,030104 developmental biology ,Lamin ,DNA Damage ,Research Article - Abstract
Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation in LMNA that produces an aberrant lamin A protein, progerin. The accumulation of progerin in HGPS cells leads to an aberrant nuclear morphology, genetic instability, and p53-dependent premature senescence. How p53 is activated in response to progerin production is unknown. Here we show that young cycling HGPS fibroblasts exhibit chronic DNA damage, primarily in S phase, as well as delayed replication fork progression. We demonstrate that progerin binds to PCNA, altering its distribution away from replicating DNA in HGPS cells, leading to γH2AX formation, ATR activation, and RPA Ser33 phosphorylation. Unlike normal human cells that can be immortalized by enforced expression of telomerase alone, immortalization of HGPS cells requires telomerase expression and p53 repression. In addition, we show that the DNA damage response in HGPS cells does not originate from eroded telomeres. Together, these results establish that progerin interferes with the coordination of essential DNA replication factors, causing replication stress, and is the primary signal for p53 activation leading to premature senescence in HGPS. Furthermore, this damage response is shown to be independent of progerin farnesylation, implying that unprocessed lamin A alone causes replication stress.
- Published
- 2017
7. E-mail communication practices and preferences among patients and providers in a large comprehensive cancer center
- Author
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Natalie Cook, Monika K. Krzyzanowska, Alice Chia-chi Wei, Aditi Dobriyal, Manjula Maganti, Jolie Ringash, and Michal Sheinis
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Younger age ,Adolescent ,Patients ,education ,MEDLINE ,Cancer Care Facilities ,Logistic regression ,Patient care ,Electronic mail ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Surveys and Questionnaires ,Health care ,Humans ,Medicine ,Center (algebra and category theory) ,030212 general & internal medicine ,Young adult ,Aged ,Aged, 80 and over ,Oncologists ,Physician-Patient Relations ,Electronic Mail ,Manchester Cancer Research Centre ,Oncology (nursing) ,business.industry ,Communication ,Health Policy ,ResearchInstitutes_Networks_Beacons/mcrc ,Cancer ,Patient Preference ,Middle Aged ,medicine.disease ,Oncology ,030220 oncology & carcinogenesis ,Family medicine ,Female ,business - Abstract
Purpose: Little is known about how electronic mail (e-mail) is currently used in oncology practice to facilitate patient care. The objective of our study was to understand the current e-mail practices and preferences of patients and physicians in a large comprehensive cancer center. Methods: Separate cross-sectional surveys were administered to patients and physicians (staff physicians and clinical fellows) at the Princess Margaret Cancer Centre. Logistic regression was used to identify factors associated with current e-mail use. Record review was performed to assess the impact of e-mail communication on care. Results: The survey was completed by 833 patients. E-mail contact with a member of the health care team was reported by 41% of respondents. The team members contacted included administrative assistants (52%), nurses (45%), specialist physicians (36%), and family physicians (18%). Patient factors associated with a higher likelihood of e-mail contact with the health care team included younger age, higher education, higher income, enrollment in a clinical trial, and receipt of multiple treatments. Eighty percent of physicians (n = 63 of 79) reported previous contact with a patient via e-mail. Physician factors associated with a greater likelihood of e-mail contact with patients included older age, more senior clinical position, and higher patient volume. Nine hundred sixty-two patient records were reviewed, with e-mail correspondence documented in only 9% of cases. Conclusion: E-mail is commonly used for patient care but is poorly documented. The use of e-mail in this setting can be developed with appropriate guidance; however, there may be concerns about widening the gap between certain groups of patients.
- Published
- 2016
8. Angiosarcoma of the Vulva: A Case Report
- Author
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Matthew Cesari, Amanda Selk, and Michal Sheinis
- Subjects
Pathology ,medicine.medical_specialty ,Hemangiosarcoma ,Malignancy ,Vulva ,Lesion ,03 medical and health sciences ,Antibodies, Monoclonal, Murine-Derived ,0302 clinical medicine ,Biopsy ,Medicine ,Humans ,Angiosarcoma ,Vulvar neoplasm ,Microscopy ,030219 obstetrics & reproductive medicine ,medicine.diagnostic_test ,Vulvar Neoplasms ,business.industry ,Histocytochemistry ,food and beverages ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,medicine.disease ,Immunohistochemistry ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,sense organs ,medicine.symptom ,business - Abstract
This case illustrates that a very benign looking lesion can be an aggressive cancer. Vulvar lesions need a biopsy to rule out malignancy if they are painful, progressing in size, or changing in appearance.
- Published
- 2015
9. O-OBS/GYN-S-045 Ignorance Is Bliss: Women’s Knowledge Regarding Age-related Pregnancy Risks
- Author
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Michal Sheinis, Amanda Selk, Nicole Carpe, and Shira Gold
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medicine.medical_specialty ,Pregnancy ,business.industry ,media_common.quotation_subject ,Obstetrics and Gynecology ,Ignorance ,medicine.disease ,BLISS ,Family medicine ,Age related ,medicine ,business ,computer ,media_common ,computer.programming_language - Published
- 2016
10. O-OBS/GYN-S-046 Patient Knowledge Regarding Prenatal Screening Options for Trisomy 21: A Canadian Hospital’s Experience
- Author
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Kira Bensimon, Amanda Selk, and Michal Sheinis
- Subjects
Pediatrics ,medicine.medical_specialty ,Prenatal screening ,business.industry ,Family medicine ,medicine ,Obstetrics and Gynecology ,Trisomy ,medicine.disease ,business - Published
- 2016
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