1. Histopathologic Features of Mucosal Head and Neck Cancer Cachexia
- Author
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Alexander J. Jones, Leah J. Novinger, Andrea Bonetto, Kyle P. Davis, Marelle M. Giuliano, Avinash V. Mantravadi, Michael W. Sim, Michael G. Moore, and Jessica A. Yesensky
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective. Determine the histopathologic features that correlate with head and neck cancer (HNC) cachexia. Methods. A single-institution, retrospective study was performed on adults with HPV-negative, mucosal squamous cell carcinoma of the aerodigestive tract undergoing resection and free flap reconstruction from 2014 to 2019. Patients with distant metastases were excluded. Demographics, comorbidities, preoperative nutrition, and surgical pathology reports were collected. Comparisons of histopathologic features and cachexia severity were made. Results. The study included 222 predominantly male (64.9%) patients aged 61.3 ± 11.8 years. Cachexia was identified in 57.2% patients, and 18.5% were severe (≥15% weight loss). No differences in demographics were identified between the groups. Compared to control, patients with severe cachexia had lower serum hemoglobin (p=0.048) and albumin (p
- Published
- 2024
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