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3. A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study

Author

Benedetti, M, Pugliatti, M, Dalessandro, R, BEGHI, ETTORE, Chiò, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Raschetti, R, Abruzzi, L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, AM, Borsato, C, Bortolotto, S, Bottacchi, EF, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, SI, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, AM, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, NA, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, FERRARESE, CARLO, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, DM, Passarella, B, Pavesi, G, Penza, MT, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, GM, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, M, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, MR, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, Zoccolella, S., Benedetti, Md, Pugliatti, M, D'Alessandro, R, Beghi, E, Chiò, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Comi, Giancarlo, Raschetti, R, ITANG Study, Group, Giometto, B, Benedetti, M, Dalessandro, R, Abruzzi, L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, A, Borsato, C, Bortolotto, S, Bottacchi, E, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, S, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, A, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, N, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, D, Passarella, B, Pavesi, G, Penza, M, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, G, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, M, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, M, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, and Zoccolella, S

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Epidemiology, Population, Guillain-Barre Syndrome, Rate ratio, NO, Young Adult, Axonal and demyelinating GBS, Guillain-Barré syndrome, Incidence, Prospective study, Trend, Neurology (clinical), Aged, Aged, 80 and over, Female, Humans, Italy, Middle Aged, 80 and over, medicine, Young adult, education, Prospective cohort study, education.field_of_study, Guillain-Barre syndrome, business.industry, Medicine (all), Incidence (epidemiology), medicine.disease, Vaccination, Settore MED/26 - NEUROLOGIA, business, Human
Abstract

Background: To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

Published
2015

5. A Multicentric Prospective Incidence Study of Guillain-Barre Syndrome in Italy. the ITANG Study

Author

Benedetti, M. D., Pugliatti, M., Dalessandro, R., Beghi, E., Chio, A., Logroscino, G., Filippini, G., Galeotti, F., Massari, M., Santuccio, C., Raschetti R., Abruzzi L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, Am, Borsato, C, Bortolotto, S, Bottacchi, Ef, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, Si, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, Am, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, Na, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, Eugenio, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile-Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, Dm, Passarella, B, Pavesi, G, Penza, Mt, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, Gm, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, Mg, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, Mr, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, Zoccolella, S., Magni E (ORCID:0000-0002-2235-2280), Benedetti, M. D., Pugliatti, M., Dalessandro, R., Beghi, E., Chio, A., Logroscino, G., Filippini, G., Galeotti, F., Massari, M., Santuccio, C., Raschetti R., Abruzzi L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, Am, Borsato, C, Bortolotto, S, Bottacchi, Ef, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, Si, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, Am, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, Na, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, Eugenio, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile-Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, Dm, Passarella, B, Pavesi, G, Penza, Mt, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, Gm, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, Mg, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, Mr, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, Zoccolella, S., and Magni E (ORCID:0000-0002-2235-2280)

Abstract

To assess Guillain-Barre syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

Published
2015

8. Efficacia a lungo termine del trattamento con Oxcarbazepina in monoterapia e in add-on: L'esperienza clinica nel Triveneto dopo un anno di follow-up

Author

Pauletto, Giada, Privato, Fiorenza, Bergonzi, Paolo, Amerio, R., Bassetti, M. A., Bongiovanni, G., Cagnin, G., Candrago, R. M., Dolso, Pierluigi, Durisotti, C., Garofalo, P. G., Gigli, Gian Luigi, Masè, G., Micaglio, G., Muneratti, V., Niego, R., Paladin, F., Panico, ANNA CLARA, Rozza, L., Serena, Marina, Stenta, G., Tonon, A., Zamagni, M., and Zanoni, T.

Subjects
Efficacy, Oxcarbazepine, Safety, Neurology (clinical)
Published
2004

9. L'esperienza della terapia con oxcarbazepina nel triveneto

Author

Pauletto, Giada, Privato, Fiorenza, Bergonzi, Paolo, Amerio, R., Bassetti, M. A., Benetello, Pierpaola, Bongiovanni, G., Cagnin, G., Candeago, R. M., Dolso, Pierluigi, Garofalo, P. G., Gigli, Gian Luigi, Masè, G., Micaglio, G. F., Miottello, P., Muneratti, V., Niego, R., Paladin, F., Panico, ANNA CLARA, Rozza, L., Serena, Marina, Stenta, G., Tonon, A., Zamagni, M., and Zanoni, T.

Subjects
Efficacy, Oxcarbazepine, Safety, Neurology (clinical)
Published
2003

14. Age-Dependent Requirements of Cultured Spinal Cord Neurons

Author

Askanas, Micaglio G, Moriwaka F, and Engel Wk

Subjects
medicine.medical_specialty, Central nervous system, Gestational Age, Age dependent, Biology, Choline O-Acetyltransferase, 2',3'-Cyclic-nucleotide 3'-phosphodiesterase, Developmental Neuroscience, Internal medicine, medicine, Animals, Cells, Cultured, Neurons, Fetus, Rats, Inbred Strains, Embryo, Embryo, Mammalian, Spinal cord, Choline acetyltransferase, Rats, medicine.anatomical_structure, Endocrinology, Spinal Cord, nervous system, Neurology, GDF7, lipids (amino acids, peptides, and proteins), Neuroscience
Abstract

Biochemical response of spinal motor neurons (SMNs) to putative trophic factors present in the fetal calf serum (FCS) or released from the native glial cells was evaluated in ventral spinal cord cultures of 12- to 14- and 16- to 18-day embryos (before and after death of many SMNs in vivo) considering choline acetyltransferase and 2',3'-cyclic 3'phosphohydrolase as the biochemical markers of SMNs and oligodendrocytes respectively. Cultured SMNs of older embryos were more dependent than those of younger embryos on glial cells and on FCS putative trophic factors. FCS seemed more important than glial cells for survival of both older and younger SMNs and its withdrawal resulted in more prominent and longer neurite outgrowth. Our study demonstrates that the response of SMNs to trophic factors depends on the age of the rat embryos from which they were cultured.

Published
1988

19. Quantitative histopathology in congenital myopathies

Author

Micaglio G, Mb, Ceccato, Trevisan C, and Corrado Angelini

Subjects
Adult, Male, Adolescent, Muscular Diseases, Child, Preschool, Muscles, Humans, Infant, Female, Middle Aged, Child
Abstract

A histo-morphometric analysis has been carried out in 23 muscle biopsies obtained from patients with congenital myopathies (6 nemaline m., 10 centronuclear m., 4 central core m., 3 multicore m.) in order to improve diagnosis and to confirm the data available in literature. No relationship has been found between the severity of the disease and the histo-pathological features as previously described. Nevertheless, the following pathological aspects diverge from previous reports: a) the absence of rods within the nuclei and of mitochondrial abnormalities in nemaline myopathy; b) the presence of type I fiber hypertrophy and of mitochondrial alterations in 30% of the patients with centronuclear myopathy; c) the presence of cores even in type II fibers, mitochondrial abnormalities, nucleosis, inflammatory cellular reaction and fibrosis in addition to the absence of rods in central core myopathy; d) the type I fiber hypertrophy in all patients with multicore myopathy.

Published
1987

24. Sensory-motor conduction time in amyotrophic lateral sclerosis

Author

Facco, E., Micaglio, G., Liviero, M. C., Ceccato, M. B., Toffoletto, F., Martinuzzi, A., and Corrado Angelini

Subjects
Adult, Male, Motor Neurons, Evoked Potentials, Somatosensory, Amyotrophic Lateral Sclerosis, Neural Conduction, Humans, Female, Middle Aged, Median Nerve
Abstract

19 ALS patients were submitted to motor evoked potentials (MEP) and F-wave from thenar muscles. Somatosensory evoked potentials (SEP) from median nerve were recorded as well in 16 patients. MEP were bilaterally absent in 4 patients (21%) and monolaterally absent in 6 patients (3.6%). Among patients with recordable waves, MEP and F-wave were significantly delayed. Their upper motor neuron conduction time was clearly abnormal only in one case. In SEP recordings the N9-N13 was significantly delayed, but the N13-N20 was normal. Four patients showed a combined sensory-motor dysfunction (increase of both N19-N13 interval and F-wave latency).

26. 11. Cardiac Resynchronization Therapy: Different Issues.

Author

Daniotti, A., Marcon, M., Vaccari, D., Zamprogno, R., Neri, G., and Micaglio, G.

Abstract

Background There are 2 types of nocturnal respiratory disorders: the obstructive sleep apnoea (OSA) and the central sleep apnoea (CSA). Correlation of CSA with severity of cardiac disfunction and arrhythmias has been hypothesized. Aim Evaluate the prevalence of OSA/CSA in heart failure patients, the effect of cardiac resynchronyzation therapy (CRT) on OSA/CSA and the predictive value of positive response to CRT. Methods We submitted 10 pts, mean age 70y±4.8 affected by dilated cardiomyopathy, III NYHA class, EF<40%, VO2 < 15 and QRS duration >130ms to polysomnography before CRT. After CRT we repeated the exam in 5. Results We documented a prevalence of light sleep and a moderate or severe fragmentation of sleep. 6 showed an abnormal index of apnoea-hypopnoea (AHI) and number of AHI per sleep/hour: 4 had light AHI, 1 moderate AHI and 1 severe AHI. Most frequent event recorded was CSA; 2 of the 4 pts with normal AHI had OSA/CSA. In the 5 pts controlled after CTR we found improvement in sleep pattern. Conclusions Polysomnography found high prevalence of sleep disorders in our patients with heart failure. Our data suggest that CRT can improve sleep quality. [ABSTRACT FROM PUBLISHER]

Published
2005

27. Further evidence of a duplication in 17p11.2 in families with recurrence of HMSN Ia (Charcot-Marie-Tooth neuropathy type Ia).

Author

Müller E, Mostacciuolo ML, Micaglio G, Angelini C, and Danieli GA

Subjects
Charcot-Marie-Tooth Disease physiopathology, Chromosome Mapping, Electromyography, Female, Genetic Linkage, Humans, Lod Score, Male, Pedigree, Polymorphism, Genetic, Recurrence, Charcot-Marie-Tooth Disease genetics, Chromosomes, Human, Pair 17, Multigene Family
Abstract

Five Italian families with recurrence of cases of Charcot-Marie-Tooth disease (type Ia) were analysed using three closely linked DNA probes that detect polymorphisms in the region 17p11.2. The probe pVAW409R3 detected the presence of a duplication in all the affected subjects, but not in the subjects with normal electromyographic (EMG) findings. This observation confirms previous data indicating the association of the duplication with the disease, suggesting that, at least in populations of European origin, the duplication might be the molecular feature diagnostic of the pathological trait.

Published
1992
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28. Evolution of cardiac involvement in progressive ophthalmoplegia with deleted mitochondrial DNA.

Author

Melacini P, Angelini C, Buja G, Micaglio G, and Valente ML

Subjects
Adult, Blepharoptosis complications, Cardiomyopathy, Dilated pathology, Electrocardiography, Female, Heart Block pathology, Heart Block physiopathology, Histocytochemistry, Humans, Mitochondria, Muscle analysis, Cardiomyopathy, Dilated metabolism, DNA analysis, Heart Block metabolism, Mitochondria, Heart analysis, Myocardium pathology, Ophthalmoplegia metabolism
Abstract

A 43-year-old woman with progressive external ophthalmoplegia developed a bifascicular block and dilatation of the right ventricle during 4 years of follow-up. Histochemical and electron microscopy studies detected mitochondrial abnormalities in ocular, skeletal muscle and cardiac biopsies. This case registers disease progression from the external ocular to the skeletal and cardiac muscles. Mitochondrial DNA was deleted in relation to the morphological abnormality.

Published
1990
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29. Serum lipids, lipoprotein analysis and apoprotein A-I, A-II and B levels in Friedreich's ataxia.

Author

Baldo-Enzi G, Bernardo M, Vitale E, Baiocchi MR, Trevisan C, Micaglio GF, Angelini C, Fellin R, and Crepaldi G

Subjects
Adolescent, Adult, Child, Female, Humans, Male, Apolipoproteins A blood, Apolipoproteins B blood, Friedreich Ataxia metabolism, Lipids blood, Lipoproteins blood
Abstract

Serum lipid, lipoprotein and apoprotein parameters were evaluated in 15 patients (7 males and 8 females) with Friedreich's ataxia. Serum lipid levels in patients showed no significant differences compared to controls. Small reduction in serum phospholipid and in total HDL and HDL3 cholesterol levels were observed, and the female patients presented a slight reduced total cholesterol level; among the serum apoproteins, apo B was reduced only in the males. The most interesting findings concerned the lipoproteins, since both lipid and protein masses of the VLDL, LDL and HDL2 fractions were reduced. In reference to lipoprotein composition, however, HDL2 was the most modified fraction, showing an important protein reduction. From this point of view, this lipoprotein seems the most responsible for the changes observed in our patients. The meaning of this modified lipoprotein pattern in the pathophysiology of Friedreich's ataxia is not clear.

Published
1990
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31. Influence of TRH and TRH analogues RGH-2202 and DN-1417 on cultured ventral spinal cord neurons.

Author

Askanas V, Engel WK, Eagleson K, and Micaglio G

Subjects
Adult, Animals, Axons drug effects, Cells, Cultured, Choline O-Acetyltransferase metabolism, Embryo, Mammalian, Humans, Motor Neurons drug effects, Motor Neurons physiology, Muscle Contraction drug effects, Neurons drug effects, Neurons ultrastructure, Rats, Rats, Inbred Strains, Axons ultrastructure, Neurons physiology, Spinal Cord physiology, Thyrotropin-Releasing Hormone analogs & derivatives, Thyrotropin-Releasing Hormone pharmacology
Published
1989
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33. Psychiatric disturbances associated with myasthenia gravis.

Author

Magni G, Micaglio GF, Lalli R, Bejato L, Candeago MR, Merskey H, and Angelini C

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Thymectomy, Mental Disorders complications, Myasthenia Gravis complications
Abstract

Seventy-four myasthenic patients (54 F, 20 M; mean age 49.6 years) were evaluated using the diagnostic criteria of the DSM-III in order to investigate the prevalence of psychiatric disturbances in this order. Fifty-one had had thymectomies, of whom 28 females had hyperplasia, two females and five males had involution of the thymus, and 10 females and six males had thymomata. Psychiatric disturbances were observed in 38 subjects (51%), in particular, adjustment disorders with depressed mood and mixed emotional features (19%) (22% including adjustment disorder with anxious mood), affective disorders (13.5%) and personality disorders (18%).

Published
1988
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34. [Myopathies caused by defects of lipid and carbohydrate metabolism].

Author

Angelini C, Martinuzzi A, Micaglio G, and Vergani L

Subjects
Carbohydrate Metabolism, Inborn Errors classification, Carbohydrate Metabolism, Inborn Errors metabolism, Fatty Acids metabolism, Glycogen Storage Disease classification, Glycogen Storage Disease etiology, Glycogen Storage Disease metabolism, Humans, Lipid Metabolism, Lipid Metabolism, Inborn Errors classification, Lipid Metabolism, Inborn Errors metabolism, Muscles metabolism, Muscular Diseases classification, Muscular Diseases metabolism, Syndrome, Carbohydrate Metabolism, Inborn Errors complications, Lipid Metabolism, Inborn Errors complications, Muscular Diseases etiology
Published
1988

35. Age-dependent requirements of cultured spinal cord neurons.

Author

Micaglio G, Askanas V, Moriwaka F, and Engel WK

Subjects
Animals, Cells, Cultured, Choline O-Acetyltransferase metabolism, Embryo, Mammalian, Gestational Age, Rats, Rats, Inbred Strains, Spinal Cord cytology, Neurons cytology, Spinal Cord embryology
Abstract

Biochemical response of spinal motor neurons (SMNs) to putative trophic factors present in the fetal calf serum (FCS) or released from the native glial cells was evaluated in ventral spinal cord cultures of 12- to 14- and 16- to 18-day embryos (before and after death of many SMNs in vivo) considering choline acetyltransferase and 2',3'-cyclic 3'phosphohydrolase as the biochemical markers of SMNs and oligodendrocytes respectively. Cultured SMNs of older embryos were more dependent than those of younger embryos on glial cells and on FCS putative trophic factors. FCS seemed more important than glial cells for survival of both older and younger SMNs and its withdrawal resulted in more prominent and longer neurite outgrowth. Our study demonstrates that the response of SMNs to trophic factors depends on the age of the rat embryos from which they were cultured.

Published
1988
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38. Heterogeneity of Charcot-Marie-Tooth disease suggested by a linkage study.

Author

Micaglio G, Fardin P, Battilana M, Lombardi A, Mostacciuolo ML, Danieli GA, and Angelini C

Subjects
Biopsy, Charcot-Marie-Tooth Disease ethnology, Charcot-Marie-Tooth Disease genetics, Chromosomes, Human, Pair 1, Electromyography, Female, Genetic Linkage, Humans, Italy, Male, Neural Conduction, Pedigree, Peroneal Nerve pathology, Charcot-Marie-Tooth Disease classification, Muscular Atrophy, Spinal classification
Published
1988

39. Sensory-motor conduction time in amyotrophic lateral sclerosis.

Author

Facco E, Micaglio G, Liviero MC, Ceccato MB, Toffoletto F, Martinuzzi A, and Angelini C

Subjects
Adult, Female, Humans, Male, Median Nerve physiopathology, Middle Aged, Amyotrophic Lateral Sclerosis physiopathology, Evoked Potentials, Somatosensory physiology, Motor Neurons physiology, Neural Conduction
Abstract

19 ALS patients were submitted to motor evoked potentials (MEP) and F-wave from thenar muscles. Somatosensory evoked potentials (SEP) from median nerve were recorded as well in 16 patients. MEP were bilaterally absent in 4 patients (21%) and monolaterally absent in 6 patients (3.6%). Among patients with recordable waves, MEP and F-wave were significantly delayed. Their upper motor neuron conduction time was clearly abnormal only in one case. In SEP recordings the N9-N13 was significantly delayed, but the N13-N20 was normal. Four patients showed a combined sensory-motor dysfunction (increase of both N19-N13 interval and F-wave latency).

Published
1989

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