Back to Search
Start Over
Quantitative histopathology in congenital myopathies
- Source :
- Scopus-Elsevier, Corrado Angelini, Europe PubMed Central
- Publication Year :
- 1987
-
Abstract
- A histo-morphometric analysis has been carried out in 23 muscle biopsies obtained from patients with congenital myopathies (6 nemaline m., 10 centronuclear m., 4 central core m., 3 multicore m.) in order to improve diagnosis and to confirm the data available in literature. No relationship has been found between the severity of the disease and the histo-pathological features as previously described. Nevertheless, the following pathological aspects diverge from previous reports: a) the absence of rods within the nuclei and of mitochondrial abnormalities in nemaline myopathy; b) the presence of type I fiber hypertrophy and of mitochondrial alterations in 30% of the patients with centronuclear myopathy; c) the presence of cores even in type II fibers, mitochondrial abnormalities, nucleosis, inflammatory cellular reaction and fibrosis in addition to the absence of rods in central core myopathy; d) the type I fiber hypertrophy in all patients with multicore myopathy.
Details
- ISSN :
- 00356344
- Volume :
- 57
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Rivista di neurologia
- Accession number :
- edsair.pmid.dedup....796d6e923197b8cd9911004bcdeba3ee