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123 results on '"Meyer, E. F."'

7. Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors

Author

Gomis-Rüth, F. X., Meyer, E. F., Kress, L. F., and Politi, V.

Subjects
ADAM Proteins, Sequence Homology, Amino Acid, X-Ray Diffraction, Protein Conformation, Drug Design, Crotalid Venoms, Humans, Metalloendopeptidases, ADAM17 Protein, Enzyme Inhibitors, Peptides, Research Article
Abstract

Crotalus adamanteus snake venom adamalysin II is the structural prototype of the adamalysin or ADAM family comprising proteolytic domains of snake venom metalloproteinases, multimodular mammalian reproductive tract proteins, and tumor necrosis factor alpha convertase, TACE, involved in the release of the inflammatory cytokine, TNFalpha. The structure of adamalysin II in noncovalent complex with two small-molecule right-hand side peptidomimetic inhibitors (Pol 647 and Pol 656) has been solved using X-ray diffraction data up to 2.6 and 2.8 A resolution. The inhibitors bind to the S'-side of the proteinase, inserting between two protein segments, establishing a mixed parallel-antiparallel three-stranded beta-sheet and coordinate the central zinc ion in a bidentate manner via their two C-terminal oxygen atoms. The proteinase-inhibitor complexes are described in detail and are compared with other known structures. An adamalysin-based model of the active site of TACE reveals that these small molecules would probably fit into the active site cleft of this latter metalloproteinase, providing a starting model for the rational design of TACE inhibitors.

Published
1998

8. ChemInform Abstract: Design, Synthesis, and Kinetic Evaluation of a Unique Class of Elastase Inhibitors, the Peptidyl α-Ketobenzoxazoles, and the X- Ray Crystal Structure of the Covalent Complex Between Porcine Pancreatic Elastase and Ac-Ala-Pro-Val-2-Ben

Author

EDWARDS, P. D., primary, MEYER, E. F. JUN., additional, VIJAYALAKSHMI, J., additional, TUTHILL, P. A., additional, ANDISIK, D. A., additional, GOMES, B., additional, and STRIMPLER, A., additional

Published
2010
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9. Acetazolamide or dexamethasone use versus placebo to prevent acute mountain sickness on Mount Rainier

Author

Ellsworth, A. J., Meyer, E. F., and Larson, E. B.

Subjects
Acetazolamide, Adult, Male, Placebos, Double-Blind Method, Humans, Female, Altitude Sickness, human activities, Dexamethasone, Research Article, Mountaineering
Abstract

Eighteen climbers actively ascended Mount Rainier (elevation 4,392 m) twice during a randomized, double-blind, concurrent, placebo-controlled, crossover trial comparing the use of acetazolamide, 250 mg, dexamethasone, 4 mg, and placebo every 8 hours as prophylaxis for acute mountain sickness. Each subject was randomly assigned to receive placebo during one ascent and one of the active medications during the other ascent. Assessment of acute mountain sickness was performed using the Environmental Symptoms Questionnaire and a clinical interview. At the summit or high point attained above base camp, the use of dexamethasone significantly reduced the incidence of acute mountain sickness and the severity of symptoms. Cerebral and respiratory symptom severity scores for subjects receiving dexamethasone (0.26 +/- 0.16 and 0.20 +/- 0.19, respectively) were significantly lower than similar scores for both acetazolamide (0.80 +/- 0.80 and 1.20 +/- 1.05; P = 0.25) and placebo (1.11 +/- 1.02 and 1.45 +/- 1.27; P = .025). Neither the use of dexamethasone nor that of acetazolamide measurably affected other physical or mental aspects. Compared with placebo, dexamethasone appears to be effective for prophylaxis of symptoms associated with acute mountain sickness accompanying rapid ascent. The precise role of dexamethasone for the prophylaxis of acute mountain sickness is not known, but it can be considered for persons without contraindications who are intolerant of acetazolamide, for whom acetazolamide is ineffective, or who must make forced, rapid ascent to high altitude for a short period of time with a guaranteed retreat route.

Published
1991

10. PROJECT ON MARINE BIOLOGY

Author

Meyer, E. F., primary, Mills, Robert, primary, Foster, Lucile E., primary, Edwards, Mary C., primary, Gorbenko, Alex, primary, and Horn, Bernard, primary

Published
1951
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25. Characterization of the Miscibility of Poly(butyl methacrylate) with a Nonylphenol Ethoxylate Surfactant and with Various Poly(ethylene glycol) Oligomers

Author

Odrobina, E., Feng, J., Kawaguchi, S., Winnik, M. A., Neag, M., and Meyer, E. F.

Abstract

Previous experiments from the Winnik group (e.g., Macromol. Rapid Commun. 1995, 16, 861) have established that several nonylphenol ethoxylate surfactants were miscible with poly(butyl methacrylate) (PBMA) latex films at 90 °C, and act as plasticizers to accelerate polymer diffusion rates in the films. Here we turn our attention to the question of miscibility at room temperature. Using modulated DSC, we show that a nonylphenol ethoxylate (NP-20, with 20 ethylene oxide units, EO20) has only limited (ca. 2 wt %) miscibility with high molecular weight PBMA latex films at room temperatures and that corresponding poly(ethylene glycol) (PEG) oligomers EOx (x = 10, 20) have even lower miscibility. Miscibility is detected as a decrease in the glass transition temperature of the polymer; and immiscibility, as a melting endotherm of the surfactant component. In addition, we examine the influence of the EOx oligomers on the polymer diffusion rate in PBMA latex films. Oligomers larger than EO10 retard the rate of interparticle polymer diffusion.

Published
1998

26. Synthesis, Characterization, and Structure of Tri-micron-halogeno- hexacarbonyldirhenate(I) Salts of Monocationic Porphyrin Acids

Author

TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMISTRY, Hrung, C. P., Tsutsui, M., Cullen, D. L., Meyer, E. F., Jr, Morimoto, C. N., TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMISTRY, Hrung, C. P., Tsutsui, M., Cullen, D. L., Meyer, E. F., Jr, and Morimoto, C. N.

Abstract

The metal-carbonyl insertion method has been found useful for the preparation of bimetallic porphyrin complexes of rhodium, rhenium, and technetium. Metal carbonly halides are more reactive reagents than metal carbonyls for the synthesis of bimetallic complexes of porphyrins as well as bimetallic salts of porphyrin acids.

Published
1978

27. Salt-Type Complexes of Porphyrins: Monocation Octaethyl Porphinium Tri-u-halogeno-hexacarbonyldirhenate (I).

Author

TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMISTRY, Hrung,C. P., Tsutsui,Minoru, Cullen,D. L., Meyer,E. F. , Jr, TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMISTRY, Hrung,C. P., Tsutsui,Minoru, Cullen,D. L., and Meyer,E. F. , Jr

Abstract

The synthesis and characterization of a monocationic porphyrin species which includes a new anionic halogenocarbonyl rhenium (I) species as the cation are reported. By the reation of a 2:1 mole ration of rhenium pentacarbonyl chloride and octaethylporphine in refluxing decalin under argon, both the dirhenium octaethylporphine, OEP(Re(CO)3)2, and a salt-type complex of (H3OEP)+(Re2(CO)6Cl3),-(cO)6 were synthesized. X-ray structural analysis of the salt-type complex revealed an unusual structure of the anionic halogenocarbonyl rhenium (I) species complex with an octaethylporphinium monocation. (Author)

Published
1976

28. Synthesis of 'Skewered Complexes': Reaction of Rhenium Carbonyl Porphyrin Complexes with Antimony Pentachloride.

Author

TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMISTRY, Kato,S., Tsutsui,Minoru, Cullen,D. L., Meyer,E. F. , Jr, TEXAS A AND M UNIV COLLEGE STATION DEPT OF CHEMISTRY, Kato,S., Tsutsui,Minoru, Cullen,D. L., and Meyer,E. F. , Jr

Abstract

The Synthesis of the first 'skewered' porphyrin complex is reported. Oxidative chlorination of rhenium carbonylporphyrin complexes by antimony pentachloride provides the first reported examples where out-of-plane metalloporphyrins react in a manner similar to cyclopentadienyl metal carbonyl complexes. From the reaction of a 1:4 or 1:2 mole ration of bis(tricarbonylrhenium)-mu-tetraphenylporphyrin and antimony pentachloride, the corresponding salts ((Re(CO)3Cl)2TPP.2SbCl6 or (Re(CO)3)(Re(CO)3)(Re(CO)3Cl)TPP.SbCl6), respectively, were obtained in good yields. A third product (Re(CO)3)2(TPP.SbCl6) was also obtained. A X-ray structure determination on this compound was carried out. The monocationic metalloporphyrin has a similar structure to that found for the starting compound. However, in this case the M-M distance of 2.95 A indicates a probably metal-metal bond of bond-order 1/2 through the porphyrin 'core'. (Author)

Published
1976

29. PROJECT ON MARINE BIOLOGY

Author

CALIFORNIA UNIV SAN FRANCISCO GEORGE WILLIAMS HOOPER FOUNDATION, Meyer, E. F., Mills, Robert, Foster, Lucile E., Edwards, Mary C., Gorbenko, Alex, Horn, Bernard, CALIFORNIA UNIV SAN FRANCISCO GEORGE WILLIAMS HOOPER FOUNDATION, Meyer, E. F., Mills, Robert, Foster, Lucile E., Edwards, Mary C., Gorbenko, Alex, and Horn, Bernard

Published
1951

30. Analysis of Underwater Acoustic Propagation Loss Math Models in Current Training Devices

Author

NAVAL TRAINING EQUIPMENT CENTER ORLANDO FL, Meyer, E F, NAVAL TRAINING EQUIPMENT CENTER ORLANDO FL, and Meyer, E F

Abstract

The report analyzes and compares the various simulation designs and math models of underwater acoustic simulation presently being used in current training devices developed by the Naval Training Device Center. The analysis contains model simplifications and their affects on acoustic propagation loss. The results of these models are compared with the results of the ray trace model developed by the Naval Air Development Center.

Published
1972

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