1. Inhibitory Effects of Luteolin 7-Methyl Ether Isolated from Wikstroemia ganpi on Tnf-A/Ifn-Γ Mixture-Induced Inflammation in Human Keratinocyte.
- Author
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Jegal J, Kim TY, Park NJ, Jo BG, Jo GA, Choi HS, Kim SN, and Yang MH
- Subjects
- Animals, Cell Line, Dermatitis, Atopic etiology, HaCaT Cells, Humans, Inflammation, Interleukin-4 metabolism, Interleukin-6 metabolism, Luteolin isolation & purification, Methyl Ethers isolation & purification, Rats, Dermatitis, Atopic drug therapy, Inflammation Mediators metabolism, Keratinocytes metabolism, Luteolin pharmacology, Methyl Ethers pharmacology, Phytotherapy, Tumor Necrosis Factor-alpha adverse effects, Wikstroemia chemistry
- Abstract
Plants of the genus Wikstroemia are traditionally used in China to treat various inflammatory diseases. The purpose of this study was to isolate the components of Wikstroemia ganpi (Siebold & Zucc.) Maxim., to evaluate their anti-atopic activities and to identify candidates with anti-atopic therapeutics. A total of 24 compounds were isolated by bioassay-guided separation, including one novel compound, which was tilianin 5-methyl ether. The anti-atopic activities of the isolated compounds were determined using TNF-α-treated RBL-2H3 cells and HaCaT cells. The mRNA expressions of IL-4, IL-6, GM-CSF, G-CSF and TRPV1 were reduced by luteolin 7-methyl ether. The study shows that the luteolin 7-methyl ether isolated from W. ganpi is a potential therapeutic agent for the treatment of atopic dermatitis.
- Published
- 2021
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