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In vitro antifungal activity of fatty acid methyl esters of the seeds of Annona cornifolia A.St.-Hil. (Annonaceae) against pathogenic fungus Paracoccidioides brasiliensis.
- Source :
-
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2011 Nov-Dec; Vol. 44 (6), pp. 777-80. - Publication Year :
- 2011
-
Abstract
- Introduction: Fatty acids are abundant in vegetable oils. They are known to have antibacterial and antifungal properties.<br />Methods: Antifungal susceptibility was evaluated by broth microdilution assay following CLSI (formerly the NCCLS) guidelines against 16 fungal strains of clinical interest.<br />Results: In this work, fatty acid methyl esters (FAME) was able to inhibit 12 clinical strains of the pathogenic fungus Paracoccidioides brasiliensis and were also active in the bioautographic assay against Cladosporium sphaerospermum.<br />Conclusions: FAME was a more potent antifungal than trimethoprim-sulfamethoxazole against P. brasiliensis under the experimental conditions tested.
- Subjects :
- Antifungal Agents isolation & purification
Candida classification
Candida drug effects
Cryptococcus gattii drug effects
Fatty Acids isolation & purification
Methyl Ethers isolation & purification
Microbial Sensitivity Tests
Seeds chemistry
Annona chemistry
Antifungal Agents pharmacology
Fatty Acids pharmacology
Methyl Ethers pharmacology
Paracoccidioides drug effects
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1678-9849
- Volume :
- 44
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Publication Type :
- Academic Journal
- Accession number :
- 22231254
- Full Text :
- https://doi.org/10.1590/s0037-86822011000600024