10 results on '"Metabolic Diseases/epidemiology"'
Search Results
2. Cardiometabolic Outcomes and Mortality in Patients with Adrenal Adenomas in a Population-based Setting:A Population-Based Cohort Study
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Zhang, Catherine D, Li, Dingfeng, Kaur, Ravinder Jeet, Ebbehoj, Andreas, Singh, Sumitabh, Atkinson, Elizabeth J, Achenbach, Sara J, Young, William F, Arlt, Wiebke, Rocca, Walter A, and Bancos, Irina
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Male ,Adult ,Epidemiology ,Adrenal Gland Neoplasms/physiopathology ,prevalence ,Adrenal Gland Neoplasms ,adrenal incidentaloma ,Minnesota/epidemiology ,Metabolic Diseases/epidemiology ,cardiovascular events ,adrenal mass ,Young Adult ,Humans ,Mortality ,Aged ,Aged, 80 and over ,Cardiovascular Diseases/epidemiology ,Cardiovascular disease (CVD) ,Middle Aged ,Prognosis ,cardiovascular outcomes ,Survival Rate ,Cardiovascular death ,incidence ,Female ,Adrenocortical Adenoma/physiopathology ,Morbidity ,Follow-Up Studies - Abstract
Context: While adrenal adenomas have been linked with cardiovascular morbidity in convenience samples of patients from specialized referral centers, large-scale population-based data are lacking. Objective: To determine the prevalence and incidence of cardiometabolic disease and assess mortality in a population-based cohort of patients with adrenal adenomas. Design: Population-based cohort study. Setting: Olmsted County, Minnesota, USA. Patients: Patients diagnosed with adrenal adenomas without overt hormone excess and age- and sex-matched referent subjects without adrenal adenomas. Main outcome measure: Prevalence, incidence of cardiometabolic outcomes, mortality. Results: (Adrenal adenomas were diagnosed in 1004 patients (58% women, median age 63 years) from 1/01/1995 to 12/31/2017. At baseline, patients with adrenal adenomas were more likely to have hypertension [adjusted odds ratio (aOR) 1.96, 95% CI 1.58-2.44], dysglycemia (aOR 1.63, 95% CI 1.33-2.00), peripheral vascular disease (aOR 1.59, 95% CI 1.32-2.06), heart failure (aOR 1.64, 95% CI 1.15-2.33), and myocardial infarction (aOR 1.50, 95% CI 1.02-2.22) compared to referent subjects. During median follow-up of 6.8 years, patients with adrenal adenomas were more likely than referent subjects to develop de novo chronic kidney disease [adjusted hazard ratio (aHR) 1.46, 95% CI 1.14-1.86], cardiac arrhythmia (aHR 1.31, 95% CI 1.08-1.58), peripheral vascular disease (aHR 1.28, 95% CI 1.05-1.55), cardiovascular events (aHR 1.33, 95% CI 1.01-1.73), and venous thromboembolic events (aHR 2.15, 95% CI 1.48-3.13). Adjusted mortality was similar between the 2 groups. Conclusion: Adrenal adenomas are associated with an increased prevalence and incidence of adverse cardiometabolic outcomes in a population-based cohort.
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- 2021
3. Epigenetics and Reproductive Medicine
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D R Brison, Kevin D. Sinclair, Adam H. Balen, J Huntriss, and Helen M. Picton
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0301 basic medicine ,medicine.medical_specialty ,Reproductive Techniques, Assisted ,Birth weight ,Reproductive medicine ,MEDLINE ,Bioinformatics ,Metabolic Diseases/epidemiology ,Epigenesis, Genetic ,Embryo Culture Techniques ,Genomic Imprinting ,03 medical and health sciences ,0302 clinical medicine ,Metabolic Diseases ,Embryo Culture Technique ,medicine ,Animals ,Birth Weight ,Humans ,Epigenetics ,Epigenesis ,030219 obstetrics & reproductive medicine ,business.industry ,Reproduction ,Cardiovascular Diseases/epidemiology ,Infant, Newborn ,Reproductive Techniques, Assisted/adverse effects ,Obstetrics and Gynecology ,Reproduction/genetics ,030104 developmental biology ,Reproductive Medicine ,Cardiovascular Diseases ,business ,Genomic imprinting - Published
- 2018
4. Second-Generation Antipsychotics in Adolescent Psychiatric Patients: Metabolic Effects and Impact of an Early Weight Change to Predict Longer Term Weight Gain
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Philippe Conus, Frederik Vandenberghe, Alexandra Najar-Giroud, Laurent Holzer, Chin B. Eap, and Anne-Emmanuelle Ambresin
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Male ,Pediatric Obesity ,Percentile ,Pediatrics ,medicine.medical_specialty ,Time Factors ,Adolescent ,medicine.medical_treatment ,Weight Gain ,Sensitivity and Specificity ,03 medical and health sciences ,0302 clinical medicine ,Metabolic Diseases ,Predictive Value of Tests ,medicine ,Humans ,Pharmacology (medical) ,Antipsychotic ,Abdominal obesity ,Antipsychotic Agents/administration & dosage ,Antipsychotic Agents/adverse effects ,Female ,Metabolic Diseases/epidemiology ,Obesity, Abdominal/epidemiology ,Pediatric Obesity/epidemiology ,Retrospective Studies ,Weight Gain/drug effects ,metabolic syndrome ,second generation antipsychotics ,weight gain ,weight monitoring ,business.industry ,Weight change ,Area under the curve ,Retrospective cohort study ,030227 psychiatry ,Psychiatry and Mental health ,Obesity, Abdominal ,Predictive value of tests ,Pediatrics, Perinatology and Child Health ,medicine.symptom ,business ,Weight gain ,030217 neurology & neurosurgery ,Antipsychotic Agents - Abstract
To examine the metabolic profile of adolescents at baseline and to determine the potential predictive power of a 1-month weight gain (WG) on weight changes during longer term second-generation antipsychotic (SGA) treatment. A retrospective chart review study, including patients between 13 and 18 years of age and treated with SGA, was conducted. Available data at baseline, 1, 3, and 12 months of treatment were recorded. Four hundred fifty-six patients were included, with a median age of 15 years. Ten percent of the patients were obese (>95th percentile) and abdominal obesity (>90th percentile) was observed in 12% of patients. In a subgroup of 42 patients with both baseline, 1, and 3-month weight data available, WG >4.5% after 1 month was found to be the best predictor (sensitivity: 100; specificity: 66; area under the curve: 83) for a WG >15% after 3 months. After adjusting for potential confounders, a threshold of WG >4% was found as being the best predictor. A worrisome prevalence of metabolic disorders was observed in an adolescent psychiatric cohort. In such patients, a WG >4% during the first month of treatment should raise concerns about weight controlling strategies. Further research is needed to confirm the present results and to determine the impact of a 1-month WG on a 1-year weight change.
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- 2018
5. The human microbiota is associated with cardiometabolic risk across the epidemiologic transition
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Jack A. Gilbert, Louise Lie, Stephanie Kliethermes, Lara R. Dugas, Brian T. Layden, Danny Baghdan, Jacob Plange-Rhule, Neil Gottel, Estelle V. Lambert, Walter F. Riesen, Beatriz Penalver Bernabe, Wolfgang Korte, Pascal Bovet, Kweku Bedu-Addo, Na Fei, Amy Luke, Terrence Forrester, and Loor, Juan J
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0301 basic medicine ,Male ,Aging ,Epidemiology ,Physiology ,Blood Pressure ,Gut flora ,Cardiovascular ,Vascular Medicine ,Ghana ,Geographical Locations ,South Africa ,0302 clinical medicine ,Risk Factors ,Medicine and Health Sciences ,Prevotella ,Uncategorized ,2. Zero hunger ,0303 health sciences ,Multidisciplinary ,biology ,Human microbiome ,Genomics ,Middle Aged ,Medical Microbiology ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Medicine ,Female ,Waist Circumference ,Research Article ,Adult ,Jamaica ,General Science & Technology ,Science ,Veillonella ,Microbial Genomics ,Microbiology ,03 medical and health sciences ,Metabolic Diseases ,Clinical Research ,Genetics ,Humans ,Dental/Oral and Craniofacial Disease ,Feces ,030304 developmental biology ,Nutrition ,Mouth ,Bacteria ,030306 microbiology ,Prevention ,Gut Bacteria ,Lachnospiraceae ,Organisms ,Biology and Life Sciences ,Cardiovascular Diseases/epidemiology ,Cardiovascular Diseases/microbiology ,Gastrointestinal Microbiome ,Ghana/epidemiology ,Jamaica/epidemiology ,Metabolic Diseases/epidemiology ,Metabolic Diseases/microbiology ,Mouth/microbiology ,South Africa/epidemiology ,United States/epidemiology ,biology.organism_classification ,United States ,030104 developmental biology ,Blood pressure ,Medical Risk Factors ,People and Places ,Africa ,North America ,Microbiome ,Lipoprotein - Abstract
Oral and fecal microbial biomarkers have previously been associated with cardiometabolic (CM) risk, however, no comprehensive attempt has been made to explore this association in minority populations or across different geographic regions. We characterized gut- and oral-associated microbiota and CM risk in 655 participants of African-origin, aged 25-45, from Ghana, South Africa, Jamaica, and the United States (US). CM risk was classified using the CM risk cut-points for elevated waist circumference, elevated blood pressure and elevated fasted blood glucose, low high-density lipoprotein (HDL), and elevated triglycerides. Gut-associated bacterial alpha diversity negatively correlated with elevated blood pressure and elevated fasted blood glucose. Similarly, gut bacterial beta diversity was also significantly differentiated by waist circumference, blood pressure, triglyceridemia and HDL-cholesterolemia. Notably, differences in inter- and intra-personal gut microbial diversity were geographic-region specific. Participants meeting the cut-points for 3 out of the 5 CM risk factors were significantly more enriched with Lachnospiraceae, and were significantly depleted of Clostridiaceae, Peptostreptococcaceae, andPrevotella. The predicted relative proportions of the genes involved in the pathways for lipopolysaccharides (LPS) and butyrate synthesis were also significantly differentiated by the CM risk phenotype, whereby genes involved in the butyrate synthesis via lysine, glutarate and 4-aminobutyrate/succinate pathways and LPS synthesis pathway were enriched in participants with greater CM risk. Furthermore, inter-individual oral microbiota diversity was also significantly associated with the CM risk factors, and oral-associatedStreptococcus, Prevotella, andVeillonellawere enriched in participants with 3 out of the 5 CM risk factors. We demonstrate that in a diverse cohort of African-origin adults, CM risk is significantly associated with reduced microbial diversity, and the enrichment of specific bacterial taxa and predicted functional traits in both gut and oral environments. As well as providing new insights into the associations between the gut and oral microbiota and CM risk, this study also highlights the potential for novel therapeutic discoveries which target the oral and gut microbiota in CM risk.
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- 2019
6. Psychosocial Stress Over the Lifespan, Psychological Factors, and Cardiometabolic Risk in the Community
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Mehdi Gholam-Rezaee, Peter Vollenweider, Jennifer Glaus, Sirak Gebreab, Enrique Castelao, Roland von Känel, Pedro Marques-Vidal, Christine Kuehner, Marie-Pierre F. Strippoli, Dominique Rudaz, Aurélie M. Lasserre, Martin Preisig, Caroline L. Vandeleur, Giorgio Pistis, University of Zurich, and Gebreab, Sirak Zenebe
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Adult ,Male ,Risk ,Coping (psychology) ,Waist ,media_common.quotation_subject ,Blood lipids ,610 Medicine & health ,3202 Applied Psychology ,Body Mass Index ,Cohort Studies ,2738 Psychiatry and Mental Health ,03 medical and health sciences ,0302 clinical medicine ,Metabolic Diseases ,Adverse Childhood Experiences ,Adaptation, Psychological ,Medicine ,Personality ,Humans ,030212 general & internal medicine ,Applied Psychology ,media_common ,Aged ,Depressive Disorder, Major ,Adaptation, Psychological/physiology ,Adverse Childhood Experiences/statistics & numerical data ,Cardiovascular Diseases/blood ,Cardiovascular Diseases/epidemiology ,Cardiovascular Diseases/physiopathology ,Depressive Disorder, Major/blood ,Depressive Disorder, Major/epidemiology ,Depressive Disorder, Major/physiopathology ,Female ,Metabolic Diseases/blood ,Metabolic Diseases/epidemiology ,Metabolic Diseases/physiopathology ,Middle Aged ,Personality/physiology ,Stress, Psychological/blood ,Stress, Psychological/epidemiology ,Stress, Psychological/physiopathology ,Switzerland/epidemiology ,Waist Circumference/physiology ,business.industry ,medicine.disease ,Obesity ,Psychiatry and Mental health ,10057 Klinik für Konsiliarpsychiatrie und Psychosomatik ,Blood pressure ,Cardiovascular Diseases ,Waist Circumference ,business ,Body mass index ,030217 neurology & neurosurgery ,Stress, Psychological ,Switzerland ,Clinical psychology ,Cohort study - Abstract
OBJECTIVE: The complex relationship between psychosocial stress over the lifetime, psychological factors, and cardiometabolic risk is still poorly understood. Accordingly, our aims were (1) to independently assess the associations between childhood adversity, life-event stress in remote (earlier than the last 5 years), and recent adulthood and cardiometabolic risk, and (2) to determine the role of psychological factors including personality, coping, and depression in these associations. METHODS: The sample included 2674 adults, aged 35 to 66 years, randomly selected from urban area. Participants underwent a physical examination including the assessment of obesity markers, blood pressure, and blood lipid and glucose levels. Stress during adulthood was determined using the severity scores of 52 stressful life events. Information on adverse childhood experiences and major depressive disorders was collected using semistructured interviews, whereas personality traits and coping mechanisms were evaluated through questionnaires. RESULTS: Both childhood adversity and stress in remote adulthood were associated with elevated body mass index (β [95% confidence interval {CI}] = 0.249 [0.029 to 0.468]; 0.020 [0.006 to 0.034]), waist circumference (β [95% CI] = 0.061 [0.024 to 0.099]; 0.08 [0.04 to 0.11]), and the global cardiometabolic risk score (β [95% CI] = 0.278 [0.017 to 0.540]; 0.017 [0.001 to 0.033]) after adjustment for sociodemographic, lifestyle, and psychological factors. In addition, childhood adversity was associated with low high density lipoprotein levels (β [95% CI] = -0.021 [-0.042 to 0.000]), as well as increased fat mass and systolic blood pressure levels (β [95% CI] = 0.506 [0.165 to 0.846]; 0.952 [0.165 to 1.740]) and stress in remote adulthood with apolipoprotein B levels (β [95% CI] = 0.607 [0.312 to 0.901]). Psychological factors did not account for these associations and were not effect modifiers. CONCLUSIONS: Our data demonstrate that psychosocial stress during childhood and remote adulthood favor adiposity and abnormal lipid metabolism.
- Published
- 2018
7. Common psychiatric and metabolic comorbidity of adult attention-deficit/hyperactivity disorder: A population-based cross-sectional study
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Henrik Larsson, Jan Haavik, Søren Dalsgaard, Catharina A. Hartman, Jaanus Harro, Rob B.K. Wanders, Qi Chen, Tor-Arne Hegvik, Kari Klungsøyr, Stephen V. Faraone, Cæcilie Ottosen, and Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)
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Male ,SYMPTOMS ,Bipolar Disorder ,Cross-sectional study ,lcsh:Medicine ,Blood Pressure ,Comorbidity ,Anxiety ,Metabolic Diseases/epidemiology ,Vascular Medicine ,Geographical locations ,0302 clinical medicine ,Endocrinology ,Elderly ,Substance-Related Disorders/epidemiology ,Prevalence ,Medicine and Health Sciences ,Attention Deficit Disorder with Hyperactivity/epidemiology ,Young adult ,lcsh:Science ,Type 2/epidemiology ,Depression (differential diagnoses) ,Bipolar Disorder/epidemiology ,Multidisciplinary ,Depression ,Mental Disorders ,ASSOCIATION ,Middle Aged ,3. Good health ,PREVALENCE ,Type 2 Diabetes ,Substance abuse ,Europe ,Neurology ,OBESITY ,Hypertension ,Female ,medicine.symptom ,SMOKING ,Anxiety/epidemiology ,Research Article ,Adult ,medicine.medical_specialty ,Adolescent ,DEFICIT HYPERACTIVITY DISORDER ,Substance-Related Disorders ,Endocrine Disorders ,Neuropsychiatric Disorders ,03 medical and health sciences ,Young Adult ,Sex Factors ,DSM-IV ,Metabolic Diseases ,Developmental Neuroscience ,Hypertension/epidemiology ,mental disorders ,Mental Health and Psychiatry ,medicine ,Diabetes Mellitus ,Attention deficit hyperactivity disorder ,ADHD ,Humans ,Bipolar disorder ,European Union ,Psychiatry ,METAANALYSIS ,Sweden ,Depressive Disorder ,HYPERTENSION ,business.industry ,Mood Disorders ,lcsh:R ,Biology and Life Sciences ,Depressive Disorder/epidemiology ,medicine.disease ,030227 psychiatry ,Sweden/epidemiology ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2/epidemiology ,Diabetes Mellitus, Type 2 ,Attention Deficit Disorder with Hyperactivity ,Neurodevelopmental Disorders ,Age Groups ,Metabolic Disorders ,lcsh:Q ,Adhd ,Population Groupings ,People and places ,business ,030217 neurology & neurosurgery ,Mental Disorders/epidemiology ,Neuroscience - Abstract
Attention-deficit/hyperactivity disorder (ADHD) is often comorbid with other psychiatric conditions in adults. Yet, less is known about its relationship with common metabolic disorders and how sex and ageing affect the overall comorbidity patterns of adult ADHD. We aimed to examine associations of adult ADHD with several common psychiatric and metabolic conditions. Through the linkage of multiple Swedish national registers, 5,551,807 adults aged 18 to 64 years and living in Sweden on December 31, 2013 were identified and assessed for clinical diagnoses of adult ADHD, substance use disorder (SUD), depression, bipolar disorder, anxiety, type 2 diabetes mellitus (T2DM), and hypertension. Logistic regression models and regression standardization method were employed to obtain estimates of prevalence, prevalence difference (PD), and prevalence ratio (PR). All comorbid conditions of interest were more prevalent in adults with ADHD (3.90% to 44.65%) than in those without (0.72% to 4.89%), with the estimated PRs being over nine for psychiatric conditions (p < 0.001) and around two for metabolic conditions (p < 0.001). Sex differences in the prevalence of comorbidities were observed among adults with ADHD. Effect modification by sex was detected on the additive scale and/or multiplicative scale for the associations of adult ADHD with all comorbidities. ADHD remained associated with all comorbidities in older adults aged 50 to 64 when all conditions were assessed from age 50 onwards. The comorbidity patterns of adult ADHD underscore the severity and clinical complexity of the disorder. Clinicians should remain vigilant for a wide range of psychiatric and metabolic problems in ADHD affected adults of all ages and both sexes. publishedVersion
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- 2018
8. Long-term follow-up on biological risk factors, adiposity, and cardiorespiratory fitness development in a physical education intervention: a natural experiment (CHAMPS-study DK)
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Eva Jespersen, Barbara Wessner, Niels Møller, Jakob Tarp, Niels Wedderkopp, Heidi Klakk, and Anna Bugge
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Gerontology ,Program evaluation ,School ,Cardiometabolic ,Male ,medicine.medical_specialty ,Denmark ,education ,Metabolic Diseases/epidemiology ,Physical education ,03 medical and health sciences ,0302 clinical medicine ,Metabolic Diseases ,Risk Factors ,Intervention (counseling) ,Epidemiology ,Medicine ,Humans ,030212 general & internal medicine ,Child ,Adiposity ,Framingham Risk Score ,Physical Education and Training ,business.industry ,Physical activity ,Public health ,lcsh:Public aspects of medicine ,Cardiovascular Diseases/epidemiology ,Prevention ,Public Health, Environmental and Occupational Health ,Cardiorespiratory fitness ,lcsh:RA1-1270 ,Insulin resistance ,030229 sport sciences ,Lipids ,Denmark/epidemiology ,Cardiorespiratory Fitness ,Cardiovascular Diseases ,Child, Preschool ,Blood pressure ,Female ,Biostatistics ,business ,Research Article ,Follow-Up Studies ,Program Evaluation - Abstract
Background Schools are a key setting for large-scale primordial non-communicable disease prevention in young people, but little data on sustainability of impacts on cardiometabolic risk markers is available. Methods Six and a half year follow-up of a natural experiment. In 2008, six public schools in the municipality of Svendborg (Denmark) augmented their curricular physical education (intervention) and four matched schools served as controls. At long term follow up in 2015 n = 312 participants aged 5–11 years had complete data (33% of children providing necessary baseline data). The intervention, that consisted of a trebling of weekly physical education lessons and courses provided to physical education teachers, was provided at intervention schools up until 6th grade. Participants attended 6th to 10th grade at follow-up. Differences in the homeostasis model assessment of insulin resistance, blood pressure, triglycerides, cholesterol ratios, cardiorespiratory fitness, waist-circumference, and a composite score of these, between participants attending intervention and control schools were analysed by mixed linear regression models. Differences in physical activity at follow-up was analysed cross-sectionally (no baseline available) in n = 495. Results Compared to controls, children at intervention schools had a non-significant − 0.07 (− 0.32 to 0.18) standard deviations lower composite risk score 6.5 years after project initiation. Likewise, no statistically significant differences between intervention and control schools were found for any of the other outcomes (p-values ≥ 0.41). However, six of seven outcomes were in a direction favouring intervention schools. No statistically significant differences between intervention and control schools were observed for physical activity outcomes (p-values ≥ 0.13). Conclusions An augmented physical activity program including 270 min of weekly physical education provided for three to seven years did not materialize in statistically significant differences in established risk markers in children from intervention compared to control schools. As the intervention was discontinued after 6th grade, the post-intervention effect of augmented physical education throughout adolescence is unknown. School-based physical activity programs may benefit from incorporating instruments for behaviour translation to leisure time in their intervention models to increase the probability of achieving public health relevance. Trial registration ClinicalTrials.gov Identifier: NCT03510494. Electronic supplementary material The online version of this article (10.1186/s12889-018-5524-4) contains supplementary material, which is available to authorized users.
- Published
- 2018
9. Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents
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Ulf, Ekelund, Jian'an, Luan, Lauren B, Sherar, Dale W, Esliger, Pippa, Griew, Ashley, Cooper, S, Griffin, International Children's Accelerometry Database (ICAD) Collaborators, Ness, A., Puder, J., Cardon, G., Davey, R., Pate, R., Salmon, J., Anderson, L., Froberg, K., Sardinha, LB., Anderson, S., Janz, K., Kriemler, S., Reilly, J., Cooper, A., Hallal, P., and Griffin, S.
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Male ,Blood Pressure ,sedentary lifestyle ,Actigraphy/statistics & numerical data ,Adolescent ,Biological Markers/blood ,Cardiovascular Diseases/epidemiology ,Child ,Child, Preschool ,Cholesterol, HDL/blood ,Exercise ,Female ,Humans ,Insulin/blood ,Metabolic Diseases/epidemiology ,Risk Factors ,Sedentary Lifestyle ,Triglycerides/blood ,Waist Circumference ,Medicine ,Insulin ,risk factors ,Cardiometabolic risk ,child ,Insulin blood ,exercise ,blood pressure ,General Medicine ,Sedentary behavior ,waist circumference ,Cardiovascular Diseases ,metabolic diseases/epidemiology ,Biological Markers ,medicine.medical_specialty ,Physical activity ,Triglycerides blood ,Metabolic Diseases ,cholestrol, HDL/blood ,triglycerides/blood ,Triglycerides ,Sedentary lifestyle ,Sedentary time ,business.industry ,Cholesterol, HDL ,biological markers/blood ,Cholesterol hdl ,Actigraphy ,cardiovascular diseases/epidemiology ,adolescent ,Physical therapy ,Sedentary Behavior ,business ,actigraphy/statistics & numerical data ,human activities ,insulin/blood ,Biomarkers ,Demography ,child, preschool - Abstract
Context Sparse data exist on the combined associations between physical activity and sedentary time with cardiometabolic risk factors in healthy children. Objective To examine the independent and combined associations between objectively measured time in moderate- to vigorous-intensity physical activity (MVPA) and sedentary time with cardiometabolic risk factors. Design, Setting, and Participants Pooled data from 14 studies between 1998 and 2009 comprising 20 871 children (aged 4-18 years) from the International Children's Accelerometry Database. Time spent in MVPA and sedentary time were measured using accelerometry after reanalyzing raw data. The independent associations between time in MVPA and sedentary time, with outcomes, were examined using meta-analysis. Participants were stratified by tertiles of MVPA and sedentary time. Main Outcome Measures Waist circumference, systolic blood pressure, fasting triglycerides, high-density lipoprotein cholesterol, and insulin. Results Times (mean [SD] min/d) accumulated by children in MVPA and being sedentary were 30 (21) and 354 (96), respectively. Time in MVPA was significantly associated with all cardiometabolic outcomes independent of sex, age, monitor wear time, time spent sedentary, and waist circumference (when not the outcome). Sedentary time was not associated with any outcome independent of time in MVPA. In the combined analyses, higher levels of MVPA were associated with better cardiometabolic risk factors across tertiles of sedentary time. The differences in outcomes between higher and lower MVPA were greater with lower sedentary time. Mean differences in waist circumference between the bottom and top tertiles of MVPA were 5.6 cm (95% CI, 4.8-6.4 cm) for high sedentary time and 3.6 cm (95% CI, 2.8-4.3 cm) for low sedentary time. Mean differences in systolic blood pressure for high and low sedentary time were 0.7 mm Hg (95% CI, −0.07 to 1.6) and 2.5 mm Hg (95% CI, 1.7-3.3), and for high-density lipoprotein cholesterol, differences were −2.6 mg/dL (95% CI, −1.4 to −3.9) and −4.5 mg/dL (95% CI, −3.3 to −5.6), respectively. Geometric mean differences for insulin and triglycerides showed similar variation. Those in the top tertile of MVPA accumulated more than 35 minutes per day in this intensity level compared with fewer than 18 minutes per day for those in the bottom tertile. In prospective analyses (N = 6413 at 2.1 years’ follow-up), MVPA and sedentary time were not associated with waist circumference at follow-up, but a higher waist circumference at baseline was associated with higher amounts of sedentary time at follow-up. Conclusion Higher MVPA time by children and adolescents was associated with better cardiometabolic risk factors regardless of the amount of sedentary time.
- Published
- 2012
10. Serum calcium levels are associated with novel cardiometabolic risk factors in the population-based CoLaus study
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Murielle Bochud, Olivier Bonny, Peter Vollenweider, Fred Paccaud, Vincent Mooser, Idris Guessous, and Gérard Waeber
- Subjects
Male ,Epidemiology ,medicine.medical_treatment ,lcsh:Medicine ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Cardiovascular ,Body Mass Index ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Switzerland/epidemiology ,Risk Factors ,Insulin ,Clinical Epidemiology ,lcsh:Science ,Multidisciplinary ,Calcium/blood ,Middle Aged ,3. Good health ,Cardiovascular Diseases ,Hypertension ,Medicine ,Female ,Public Health ,Switzerland ,Adult ,Cardiovascular Diseases/blood ,Cardiovascular Diseases/epidemiology ,Humans ,Metabolic Diseases/blood ,Metabolic Diseases/epidemiology ,Research Article ,medicine.medical_specialty ,chemistry.chemical_element ,030209 endocrinology & metabolism ,Calcium ,Biology ,03 medical and health sciences ,Metabolic Diseases/blood/epidemiology ,Insulin resistance ,Metabolic Diseases ,Internal medicine ,medicine ,Cardiovascular Diseases/blood/epidemiology ,Cardiovascular Disease Epidemiology ,ddc:613 ,Diabetic Endocrinology ,Adiponectin ,Endocrine Physiology ,lcsh:R ,Diabetes Mellitus Type 2 ,medicine.disease ,Biomarker Epidemiology ,chemistry ,Metabolic Disorders ,Uric acid ,lcsh:Q ,Metabolic syndrome ,Body mass index ,Oxidative stress - Abstract
BACKGROUND: Associations of serum calcium levels with the metabolic syndrome and other novel cardio-metabolic risk factors not classically included in the metabolic syndrome, such as those involved in oxidative stress, are largely unexplored. We analyzed the association of albumin-corrected serum calcium levels with conventional and non-conventional cardio-metabolic risk factors in a general adult population. METHODOLOGY/PRINCIPAL FINDINGS: The CoLaus study is a population-based study including Caucasians from Lausanne, Switzerland. The metabolic syndrome was defined using the Adult Treatment Panel III criteria. Non-conventional cardio-metabolic risk factors considered included: fat mass, leptin, LDL particle size, apolipoprotein B, fasting insulin, adiponectin, ultrasensitive CRP, serum uric acid, homocysteine, and gamma-glutamyltransferase. We used adjusted standardized multivariable regression to compare the association of each cardio-metabolic risk factor with albumin-corrected serum calcium. We assessed associations of albumin-corrected serum calcium with the cumulative number of non-conventional cardio-metabolic risk factors. We analyzed 4,231 subjects aged 35 to 75 years. Corrected serum calcium increased with both the number of the metabolic syndrome components and the number of non-conventional cardio-metabolic risk factors, independently of the metabolic syndrome and BMI. Among conventional and non-conventional cardio-metabolic risk factors, the strongest positive associations were found for factors related to oxidative stress (uric acid, homocysteine and gamma-glutamyltransferase). Adiponectin had the strongest negative association with corrected serum calcium. CONCLUSIONS/SIGNIFICANCE: Serum calcium was associated with the metabolic syndrome and with non-conventional cardio-metabolic risk factors independently of the metabolic syndrome. Associations with uric acid, homocysteine and gamma-glutamyltransferase were the strongest. These novel findings suggest that serum calcium levels may be associated with cardiovascular risk via oxidative stress.
- Published
- 2011
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