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Second-Generation Antipsychotics in Adolescent Psychiatric Patients: Metabolic Effects and Impact of an Early Weight Change to Predict Longer Term Weight Gain
- Source :
- Journal of child and adolescent psychopharmacology, vol. 28, no. 4, pp. 258-265
- Publication Year :
- 2018
- Publisher :
- Mary Ann Liebert Inc, 2018.
-
Abstract
- To examine the metabolic profile of adolescents at baseline and to determine the potential predictive power of a 1-month weight gain (WG) on weight changes during longer term second-generation antipsychotic (SGA) treatment. A retrospective chart review study, including patients between 13 and 18 years of age and treated with SGA, was conducted. Available data at baseline, 1, 3, and 12 months of treatment were recorded. Four hundred fifty-six patients were included, with a median age of 15 years. Ten percent of the patients were obese (>95th percentile) and abdominal obesity (>90th percentile) was observed in 12% of patients. In a subgroup of 42 patients with both baseline, 1, and 3-month weight data available, WG >4.5% after 1 month was found to be the best predictor (sensitivity: 100; specificity: 66; area under the curve: 83) for a WG >15% after 3 months. After adjusting for potential confounders, a threshold of WG >4% was found as being the best predictor. A worrisome prevalence of metabolic disorders was observed in an adolescent psychiatric cohort. In such patients, a WG >4% during the first month of treatment should raise concerns about weight controlling strategies. Further research is needed to confirm the present results and to determine the impact of a 1-month WG on a 1-year weight change.
- Subjects :
- Male
Pediatric Obesity
Percentile
Pediatrics
medicine.medical_specialty
Time Factors
Adolescent
medicine.medical_treatment
Weight Gain
Sensitivity and Specificity
03 medical and health sciences
0302 clinical medicine
Metabolic Diseases
Predictive Value of Tests
medicine
Humans
Pharmacology (medical)
Antipsychotic
Abdominal obesity
Antipsychotic Agents/administration & dosage
Antipsychotic Agents/adverse effects
Female
Metabolic Diseases/epidemiology
Obesity, Abdominal/epidemiology
Pediatric Obesity/epidemiology
Retrospective Studies
Weight Gain/drug effects
metabolic syndrome
second generation antipsychotics
weight gain
weight monitoring
business.industry
Weight change
Area under the curve
Retrospective cohort study
030227 psychiatry
Psychiatry and Mental health
Obesity, Abdominal
Predictive value of tests
Pediatrics, Perinatology and Child Health
medicine.symptom
business
Weight gain
030217 neurology & neurosurgery
Antipsychotic Agents
Subjects
Details
- ISSN :
- 15578992 and 10445463
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Child and Adolescent Psychopharmacology
- Accession number :
- edsair.doi.dedup.....d21fddd76b397238cd7f0733bd46f751