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Background: Mephentermine is a sympathomimetic drug widely used by professional athletes and bodybuilders for muscle-building and enhancing physical performance. This study evaluated the evidence of adverse effects associated with mephentermine use among athletes. Methods: A systematic search was performed in PubMed and Embase from inception to December 2022. The bibliographies of the included studies were examined for additional studies. Quality assessment of the included studies were done using an appropriate scale. Results: From 905 studies, 13 met the eligibility criteria. Fourteen male athletes aged 20 to 35 years experienced adverse effects. Parenteral administration of mephentermine was the most preferred route among users. The daily administered dose of mephentermine varied from 30 mg to 1200 mg. All athletes consumed mephentermine at the advice of their trainers or peers. The most common adverse effects experienced by athletes were dependence and psychosis, which developed among chronic users (used for more than 1 year). Other adverse effects were decompensated heart failure, hepatic and renal injury, and resistance to ephedrine therapy. Conclusions: Mephentermine use is associated with numerous health complications. The lack of data supporting its performance-enhancing effects, combined with its substantial toxicities, questions the usefulness of this drug in athletes. [ABSTRACT FROM AUTHOR]

Aim: The purpose of this study was to compare the efficacy of bolus dose of Phenylephrine Versus Mephentermine for hypotension correction in patients undergoing elective caesarean section surgery. Methodology: After obtaining approval from the ethical committee and obtaining informed consent, 60 parturients aged between 18 - 40 years of age and gestational age from 34 to 40 weeks posted for elective lower segment cesarean section were included. They were randomly divided into Group P (n=30) and Group M (n=30). The parameters observed were level of Anaesthesia, hemodynamic variables, number of doses required to correct hypotension and adverse effects. Results: A total of 60 patients were analyzed. Within 5 minutes of Spinal anaesthesia there was no significant difference between Group-P and Group-M on drop of average Systolic blood pressure, Diastolic blood pressure and average Heart rates at different minutes. But after administering the drug for hypotention correction Group P shows very high average SBP and DBP correction compared to Group M which is statistically significant (p<0.0001) and Group P shows a fall in the heart rate compared to Group M which is statistically significant (p<0.0001). Conclusion: Phenylephrine is observed to be hemodynamically more suitable than Mephentermine in patients undergoing elective caesarean section surgery. [ABSTRACT FROM AUTHOR]

Background: Subarachnoid block, although being highly efficient, often has limitation such as hypotension which can result in adverse maternal and fetal outcome, continues to be a matter of concern to the Anesthesiologist. The study was to compare the effect of phenylephrine, ephedrine and mephentermine, for maintenance of arterial pressure during spinal anaesthesia for caesarean section. Methodology: A prospective randomized double blinded study involving 90 patients with hypotension after subarachnoid block under spinal anesthesia was conducted, dividing them into three groups: P (Phenylephrine) 100 mcg, E (Ephedrine) 6 mg, and M (Mephentermine) 6 mg. Patients were compared based on age, weight, height, hemodynamic parameters, complications, and neonatal APGAR scores. Results: On inter-group comparison rise in systolic, diastolic and mean arterial blood pressure at 1,2,4 and 6min after drug administration were significantly high in phenylephrine group (p /= 7 in the three groups at the 1st and 5th min. Conclusion: The study found that phenylephrine, ephedrine, and mephentermine effectively maintained arterial blood pressure in intravenous bolus form during subarachnoid block for caesarean section. Phenylephrine, a fast-acting, short-lived normotensive drug, significantly reduced heart rate compared to ephedrine and mephentermine, but did not cause significant adverse effects on mother and fetus.

Context: Mephentermine by intramuscular route prevents post-spinal anesthesia hypotension. However, the intravenous route had not been tried earlier for this prophylactic purpose. Aims: Comparing the safety and efficacy of intravenous and intramuscular routes of mephentermine in preventing maternal hypotension during cesarean section (CS). The primary objective was to compare the incidences of hypotension. Methods and Material: ASA II term parturients posted for CS were randomized into three groups. Group I received intravenous mephentermine 10 mg just before spinal and 1 ml normal saline (NS) by intramuscular route 10 minutes before spinal. Group M received intramuscular mephentermine 15 mg 10 minutes before spinal and 1 ml NS by the intravenous route just before spinal. Group C received 1 ml NS intramuscularly 10 minutes before spinal and 1 ml NS by the intravenous route just before spinal. The vital parameters, episodes of hypotension, adverse events, and neonatal parameters were assessed. Results: During midterm analysis, it was found that Group I had significantly higher adverse effects, so data collection was stopped, with a total intake of 25 patients in Group M, 22 patients in Group I, and 20 patients in Group C, respectively. The incidence of hypotension was less with the use of IM (8%) and IV (22.7%) mephentermine compared to the control group (P value:

Introduction. Spinal anesthesia (SA) is widely used for cesarean sections, yet its safety in preeclamptic patients remains uncertain. This study explores the use of subarachnoid block (SAB) in preeclamptic parturients during cesarean sections. Patients and Methods. This study was a single-center hospital-based controlled clinical trial. 30 normotensive and 30 preeclamptic women undergoing cesarean section were included in the study. Heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP) and SpO2 were evaluated at one, three, five, seven, nine, 11, 13, 15, 20, 25, 30, 40, 45, 50, 55 and 60 minutes intervals after giving the block. The independent samples t-test was used for statistical analysis. Results. In the normotensive (group N) vs. preeclamptic (group PE) comparison, significant differences in weight, SBP, DBP, and MAP were noted, with higher values in group PE (p

Context: Mephentermine by intramuscular route prevents post-spinal anesthesia hypotension. However, the intravenous route had not been tried earlier for this prophylactic purpose. Aims: Comparing the safety and efficacy of intravenous and intramuscular routes of mephentermine in preventing maternal hypotension during cesarean section (CS). The primary objective was to compare the incidences of hypotension. Methods and Material: ASA II term parturients posted for CS were randomized into three groups. Group I received intravenous mephentermine 10 mg just before spinal and 1 ml normal saline (NS) by intramuscular route 10 minutes before spinal. Group M received intramuscular mephentermine 15 mg 10 minutes before spinal and 1 ml NS by the intravenous route just before spinal. Group C received 1 ml NS intramuscularly 10 minutes before spinal and 1 ml NS by the intravenous route just before spinal. The vital parameters, episodes of hypotension, adverse events, and neonatal parameters were assessed. Results: During midterm analysis, it was found that Group I had significantly higher adverse effects, so data collection was stopped, with a total intake of 25 patients in Group M, 22 patients in Group I, and 20 patients in Group C, respectively. The incidence of hypotension was less with the use of IM (8%) and IV (22.7%) mephentermine compared to the control group (P value: <0.05). Group I had significantly more adverse events like headache (59%), chest pain (36.36%), and ST changes compared to other groups (P value: <0.001). Conclusions: We conclude that the intramuscular route is better for preventing post-spinal hypotension in cesarean section with lesser maternal side effects and a better Apgar score. [ABSTRACT FROM AUTHOR]

Background and Aims: Spinal anesthesia remains the preferred choice for cesarean deliveries, but hypotension is one of the common complications which may have detrimental effects on both the mother and fetus. In this study, we compared the efficacy and adverse effects of bolus doses of ephedrine hydrochloride and mephentermine sulfate administered intravenously to treat spinal-induced hypotension and the fetal outcomes through Apgar scores and umbilical cord blood gas analysis in the lower segment cesarean section. Material and Methods: In this prospective, randomized, double-blind study, 60 patients undergoing the lower segment cesarean section (LSCS) under spinal anesthesia were randomized into two groups of 30 each using computer-generated random numbers which were kept in an opaque envelope. Patients were pre-loaded with Ringer's lactate solution 10 ml/kg before the spinal anesthesia. Hypotension was defined as the fall in systolic blood pressure of less than or equal to 20% of the baseline or systolic blood pressure of less than 90 mmHg. Whenever hypotension occurred, patients in group E (ephedrine) received a bolus dose of ephedrine 6 mg intravenous and patients in group M (mephentermine) received a bolus dose of mephentermine 6 mg intravenous. Intra-operative recording included maternal hemodynamic parameters and the number of bolus doses of study drugs required to treat maternal hypotension and the adverse effects of study drugs. The Apgar score and umbilical cord blood gas values were recorded. Data were analyzed by analysis of variance test, Student's t-test, and Chi-square test. A P value of < 0.05 was considered as significant. Results: There was a statistically significant (p < 0.05) increase in systolic and mean arterial blood pressure at the second min and fourth min after administration of ephedrine in group E compared to mephentermine in group M. The systolic blood pressure at the second min in the ephedrine group was 114.3 ± 12.06, whereas in the mephentermine group, it was 106.10 ± 8.41 and was statistically significant (p < 0.05). At the fourth min, the systolic blood pressure in the ephedrine group was 115.03 ± 8.87, whereas in the mephentermine group, it was 108.46 ± 8.10 and was statistically significant (p < 0.05). There was a transient increase in heart rate immediately after administration of spinal anesthesia. The mean number of bolus doses of vasopressor consumption was 2.4 (14.4 mg) in the ephedrine group and 2 (12 mg) in the mephentermine group. The umbilical cord blood gas analysis and Apgar scores were similar in both the groups. Three patients (10%) developed bradycardia in the mephentermine group compared to the ephedrine group (0%). The incidence of nausea (13.3% vs 3.3%) and vomiting (10% vs 1%) was higher in the ephedrine group compared to the mephentermne group, and it was not statistically significant (p > 0.05). No significant differences were observed in the umbilical arterial blood pH and Apgar scores. Conclusion: In conclusion, after hypotension, ephedrine and mephentermine administration as bolus doses are equally efficacious in preventing spinal-induced hypotension in patients undergoing the cesarean section and are associated with similar neonatal outcomes.

Background: Subarachnoid block is one of the most commonly used anaesthesia technique for lower limb surgeries. As adjuvants opioids are the most commonly used with Local Anesthetics (LA). Adjuvants are given premixed with LA loaded in a single syringe. This study was carried out to compare differences in level of sensory and motor block and incidence of hypotension whilst administering hyperbaric bupivacaine and fentanyl either in a single syringe or different syringes. The effect of administering opioid prior to LA and vice versa on abovementioned parameters were also assessed. Material and Methods: A study was performed in 100 ASA class I & II patients aged between 18-60 years, undergoing lower limb elective surgeries under spinal anaesthesia. Onset of sensory and motor block, duration of analgesia, hemodynamic stability parameters. Results: The frequency of hypotension was significantly lower in Group S compared to Group M (P < 0.05). Time till the onset of sensory block was non-significantly shorter with non-significantly higher mean level of maximal sensory block in Group S compared to Group M (P > 0.05). There was no significant difference in the time till occurrence of hypotension, duration of hypotension; mean dose of Mephentermine used for the treatment of hypotension and frequency of patients developed itching in-between the groups (P > 0.05). Conclusion: Separate syringe intrathecal injection of hyperbaric bupivacaine and Fentanyl provided a tangible improvement in the quality of sensory block and significant reduction in episodes of hypotension as compared to injection of premixed medications. Administering hyperbaric bupivacaine first followed by fentanyl leads to an early onset and prolonged duration of sensory and motor blockade.

Background and Aims: Spinal anesthesia remains the preferred choice for cesarean deliveries, but hypotension is one of the common complications which may have detrimental effects on both the mother and fetus. In this study, we compared the efficacy and adverse effects of bolus doses of ephedrine hydrochloride and mephentermine sulfate administered intravenously to treat spinal-induced hypotension and the fetal outcomes through Apgar scores and umbilical cord blood gas analysis in the lower segment cesarean section. Material and Methods: In this prospective, randomized, double-blind study, 60 patients undergoing the lower segment cesarean section (LSCS) under spinal anesthesia were randomized into two groups of 30 each using computer-generated random numbers which were kept in an opaque envelope. Patients were pre-loaded with Ringer's lactate solution 10 ml/kg before the spinal anesthesia. Hypotension was defined as the fall in systolic blood pressure of less than or equal to 20% of the baseline or systolic blood pressure of less than 90 mmHg. Whenever hypotension occurred, patients in group E (ephedrine) received a bolus dose of ephedrine 6 mg intravenous and patients in group M (mephentermine) received a bolus dose of mephentermine 6 mg intravenous. Intra-operative recording included maternal hemodynamic parameters and the number of bolus doses of study drugs required to treat maternal hypotension and the adverse effects of study drugs. The Apgar score and umbilical cord blood gas values were recorded. Data were analyzed by analysis of variance test, Student's t-test, and Chi-square test. A P value of < 0.05 was considered as significant. Results: There was a statistically significant (p < 0.05) increase in systolic and mean arterial blood pressure at the second min and fourth min after administration of ephedrine in group E compared to mephentermine in group M. The systolic blood pressure at the second min in the ephedrine group was 114.3 ± 12.06, whereas in the mephentermine group, it was 106.10 ± 8.41 and was statistically significant (p < 0.05). At the fourth min, the systolic blood pressure in the ephedrine group was 115.03 ± 8.87, whereas in the mephentermine group, it was 108.46 ± 8.10 and was statistically significant (p < 0.05). There was a transient increase in heart rate immediately after administration of spinal anesthesia. The mean number of bolus doses of vasopressor consumption was 2.4 (14.4 mg) in the ephedrine group and 2 (12 mg) in the mephentermine group. The umbilical cord blood gas analysis and Apgar scores were similar in both the groups. Three patients (10%) developed bradycardia in the mephentermine group compared to the ephedrine group (0%). The incidence of nausea (13.3% vs 3.3%) and vomiting (10% vs 1%) was higher in the ephedrine group compared to the mephentermne group, and it was not statistically significant (p > 0.05). No significant differences were observed in the umbilical arterial blood pH and Apgar scores. Conclusion: In conclusion, after hypotension, ephedrine and mephentermine administration as bolus doses are equally efficacious in preventing spinal-induced hypotension in patients undergoing the cesarean section and are associated with similar neonatal outcomes. [ABSTRACT FROM AUTHOR]

Background and Aims: Spinal anaesthesia induced hypotension (SAIH) and bradycardia may prove deleterious to both parturient and baby, hence vasopressors play a vital role in their management. Recent studies on norepinephrine as rescue vasopressor during subarachnoid block (SAB) enlighten its role for SAIH. This randomised double-blind trial was conducted to compare the effect of intermittent intravenous boluses of norepinephrine and frequently used mephentermine for management of SAIH in caesarean section (CS) to prove whether norepinephrine produces comparable effects or superior to mephentermine. Methods: After approval from Institutional Ethics Committee and registration in Clinical Trials Registry India (CTRI/2019/06/019652), 256 parturients posted for elective CS under SAB were randomly allocated into Group-N and Group-M (n = 84) using chit system, who received boluses of intravenous norepinephrine 8μg and mephentermine 6mg for SAIH, respectively. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), Response%, Apgar score and maternal complications were analysed. Results: The changes in SBP and DBP were comparable in both the groups. It was significantly low after SAB compared to baseline and significantly high compared to 1st hypotensive value in both the groups throughout the study period (

Background: Subarachnoid block is one of the most commonly used anaesthesia technique for lower limb surgeries. As adjuvants opioids are the most commonly used with Local Anesthetics (LA). Adjuvants are given premixed with LA loaded in a single syringe. This study was carried out to compare differences in level of sensory and motor block and incidence of hypotension whilst administering hyperbaric bupivacaine and fentanyl either in a single syringe or different syringes. The effect of administering opioid prior to LA and vice versa on abovementioned parameters were also assessed. Material and Methods: A study was performed in 100 ASA class I & II patients aged between 18-60 years, undergoing lower limb elective surgeries under spinal anaesthesia. Onset of sensory and motor block, duration of analgesia, hemodynamic stability parameters. Results: The frequency of hypotension was significantly lower in Group S compared to Group M (P < 0.05). Time till the onset of sensory block was non-significantly shorter with non-significantly higher mean level of maximal sensory block in Group S compared to Group M (P > 0.05). There was no significant difference in the time till occurrence of hypotension, duration of hypotension; mean dose of Mephentermine used for the treatment of hypotension and frequency of patients developed itching inbetween the groups (P > 0.05). Conclusion: Separate syringe intrathecal injection of hyperbaric bupivacaine and Fentanyl provided a tangible improvement in the quality of sensory block and significant reduction in episodes of hypotension as compared to injection of premixed medications. Administering hyperbaric bupivacaine first followed by fentanyl leads to an early onset and prolonged duration of sensory and motor blockade. [ABSTRACT FROM AUTHOR]

Case presentation: A 32-year-old professional bodybuilder presented with acute decompensated heart failure. He gave a history of anabolic androgenic steroids (AAS) use for >2 years and mephentermine use for the preceding 3 months. Management: Transthoracic echocardiography showed severe left ventricular (LV) dysfunction with a large pedunculated, mobile thrombus attached to the ventricular apex. The patient had an embolic stroke during the hospital stay, with complete neurological recovery. Following the cessation of mephentermine use, there was a steady improvement in LV function over a follow-up of 2 months. However, at 3 months, his ventricular function showed deterioration, which coincided with mephentermine reuse. Take home message: Though AAS abuse by athletes leading to such a presentation has been documented, to the best of our knowledge, a similar role of mephentermine has not been reported. [ABSTRACT FROM AUTHOR]

Mephentermine is a sympathomimetic amine, frequently used as a vasopressor. It is structurally comparable to amphetamines, and World Anti-Doping Agency has prohibited its use as a performance-enhancing drug. However, its illegal consumption by several sportspersons and those appearing for physical endurance tests is a growing concern for health-care professionals. We present a case of misuse of intravenous mephentermine by a young male who abruptly increased its amount a few days prior to the sports competition and developed acute psychosis. The case report highlights the need for strict regulations for procuring methamphetamine and effective treatment strategies for managing its misuse. [ABSTRACT FROM AUTHOR]

Background and Aims: Spinal anaesthesia induced hypotension (SAIH) and bradycardia may prove deleterious to both parturient and baby, hence vasopressors play a vital role in their management. Recent studies on norepinephrine as rescue vasopressor during subarachnoid block (SAB) enlighten its role for SAIH. This randomised double-blind trial was conducted to compare the effect of intermittent intravenous boluses of norepinephrine and frequently used mephentermine for management of SAIH in caesarean section (CS) to prove whether norepinephrine produces comparable effects or superior to mephentermine. Methods: After approval from Institutional Ethics Committee and registration in Clinical Trials Registry India (CTRI/2019/06/019652), 256 parturients posted for elective CS under SAB were randomly allocated into Group-N and Group-M (n = 84) using chit system, who received boluses of intravenous norepinephrine 8µg and mephentermine 6mg for SAIH, respectively. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), Response%, Apgar score and maternal complications were analysed. Results: The changes in SBP and DBP were comparable in both the groups. It was significantly low after SAB compared to baseline and significantly high compared to 1st hypotensive value in both the groups throughout the study period (<0.0001). HR was comparable for initial 10 min, thereafter it was significantly high in Group-M (<0.0001) till 40 min. Response% after the first bolus was significantly high in Group-N (59.30n ± 29.21 vs 39.78 ± 25.6; P = <0.0001). Conclusion: Intravenous norepinephrine is better than mephentermine with respect to high response% and stable maternal HR although both are equally effective in maintaining blood pressure following SAIH during elective CS. [ABSTRACT FROM AUTHOR]

Background: Maternal hypotension during spinal anesthesia for cesarean section is a persistent problem which can result in adverse maternal and fetal outcome. Aim: Aim of this study was to compare the efficacy of IV bolus phenylephrine, ephedrine and mephentermine for the maintenance of hemodynamic status and its effect on fetal outcome during spinal anesthesia in cesarean section. Materials and Methods: We did prospective randomized double blind study in 60 patients. They were undergoing elective cesarean section under spinal anesthesia and who developed hypotension after subarachnoid block. The patients were randomly divided into three groups of 20 each. Phenylephrine Group (Group P) received Inj. Phenylephrine 100 mcg IV, Group E received Inj. Ephedrine 6 mg IV and Group M received Inj. Mephentermine 6 mg IV bolus. Whenever hypotension occurred, patients received the study drug. After administration of drugs and their consistence maintenance till end of 60 minutes. Patients were compared with respect to age, weight, duration of surgery, Systolic BP, Diastolic BP, Mean Arterial Pressure and Heart Rate. Results: The rise of systolic, diastolic and mean arterial pressure in Group P was significantly high for first 4min of bolus dose as compared to Group E & Group M (P<0.05). APGAR scores were =7 in all the three groups. Conclusion: It was concluded that IV bolus Mephentermine is as effective as Phenylephrine and Ephedrine in maintenance of arterial blood pressure during spinal anesthesia in cesarean section with good neonatal outcome. [ABSTRACT FROM AUTHOR]

The goal of this study was to confirm the vasopressor and cardiac effects of POTENAY® INJETÁVEL (POT), a mephentermine‐based product, given to cattle with induced vascular/cardiac depression. Ten healthy Holstein cattle (206 ± 13 kg) followed a randomized‐complete‐block design (RCBD) utilizing crossover study design. Each animal randomly received (1 ml/25 kg, IM) of either POT (n = 10) or volume‐matched placebo control (0.9%NaCl, CP, n = 10). A subset of animals (n = 5) received POT first (day 0) while the remaining (n = 5) received CP; after a six‐day washout period, cattle received the opposite compound. Animals were anesthetized and catheterized for systemic/left ventricular hemodynamic monitoring. Myocardial dysfunction/hypotension was induced by increasing the end‐tidal isoflurane concentration until arterial blood pressure was 20% lower than at baseline and remained stable. Once the animal was determined to be hypotensive and hemodynamically stable, steady‐state hypotensive baseline data (BL2) were acquired, and treatment with either POT or CP was given. Data were acquired post‐treatment at every 15 min for 90 min. POT improved cardiac output (+68 L/min, ±14%, p < 0.05), MAP (+14 mmHg, ±4%, p < 0.05), HR (+22 bpm, ±8%, p < 0.05), and peak rates of ventricular pressure change during both systole (dP/dtmax: +37 mmHg/s ±13%, p < 0.05) and diastole (dP/dtmin: +31 mmHg/s, ±7%, p < 0.05). No improvements were noted following placebo‐control administration. Results indicate that POT improves cardiac performance and systemic hemodynamics in cattle with induced cardiovascular depression when given as single intramuscular injection. [ABSTRACT FROM AUTHOR]

Introduction: Subarachnoid block, although being highly efficient with lesser drug doses, often has limitation such as hypotension, continues to be a matter of concern to the anesthetist. The present study was aimed to compare the use of phenylephrine, ephedrine, and mephentermine bolus for maintenance of blood pressure during spinal anesthesia in lower abdominal surgeries. Subjects and Methods: In a randomized, prospective study, 90 adult patients of either sex who developed hypotension during surgery under subarachnoid block were allocated into three groups to receive bolus phenylephrine, ephedrine, and mephentermine. The number of boluses and time taken to recover from hypotension was noted. Occurrence of adverse effects in the perioperative and postoperative period was also noted. Results: Results were analyzed by Student's paired t-test and Chi-square test. The ANOVA test was used to compare the group variances among the study groups. P < 0.05 was considered statistically significant. Thirty-four hypotensive events (average 1.03 events/patient) took place in mephentermine group. In phenylephrine group, a total of 53 hypotensive events took place. On an average, the group had a total of 1.61 hypotensive events per patient. No hypotensive event took place in ephedrine group after the first bolus of drug (average 1 event/patient). Mean heart rate in phenylephrine group was significantly lower as compared to the other two groups (P < 0.001). Conclusion: Mephentermine and ephedrine were similar in performance, offered a better hypotensive control, and had lower recurring events as compared to phenylephrine. [ABSTRACT FROM AUTHOR]

Nonmedical use of prescription stimulants such as phentermine (PT) has been regulated by law enforcement authorities due to its euphorigenic and relaxing effects. Due to high potential for its abuse, reliable analytical methods were required to detect and identify PT and its metabolite in biological samples. Thus a dilute and shoot liquid chromatography–tandem mass spectrometric (LC–MS/MS) method was developed and validated for simultaneous determination of PT, N -hydroxyphentermine (NHOPT) and mephentermine (MPT) in urine. A 5 μL aliquot of diluted urine was injected into the LC–MS/MS system. Chromatographic separation was performed by reversed-phase C18 column with gradient elution for all analytes within 5 min. Identification and quantification were based on multiple reaction monitoring (MRM) detection. Linear least-squares regression with a 1/x 2 weighting factor was used to generate a calibration curve and the assay was linear from 50 to 15000 ng/mL (PT and MPT) and 5 to 750 ng/mL (NHOPT). The intra- and inter-day precisions were within 8.9% while the intra- and inter-day accuracies ranged from −6.2% to 11.2%. The limits of quantification were 3.5 ng/mL (PT), 1.5 ng/mL (NHOPT) and 1.0 ng/mL (MPT). Method validation requirements for selectivity, dilution integrity, matrix effect and stability were satisfied. The applicability of the developed method was examined by analyzing urine samples from drug abusers. [ABSTRACT FROM AUTHOR]

Mephentermine is structurally related to amphetamines and is banned for its use as a performance-enhancing drug in competitive sports. Limited literature is available on management of mephentermine dependence. Here, we describe a case of mephentermine dependence followed by review of literature and a discussion about its management. A 20-year-old professional wrestler presented with high-dose intravenous mephentermine use, and rapid development of dependence, in the absence of any comorbid substance use or psychiatric disorder. The client showed improvement with bupropion and individual counseling sessions. The present report highlights the need to explore effective treatment options for individuals who have been addicted to mephentermine. [ABSTRACT FROM AUTHOR]