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411 results on '"Meng, Fantao"'

25. Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

Author

Kelly, Elyza, Meng, Fantao, Fujita, Hirofumi, Morgado, Felipe, Kazemi, Yasaman, Rice, Laura C, Ren, Chongyu, Escamilla, Christine Ochoa, Gibson, Jennifer M, Sajadi, Sanaz, Pendry, Robert J, Tan, Tommy, Ellegood, Jacob, Basson, M Albert, Blakely, Randy D, Dindot, Scott V, Golzio, Christelle, Hahn, Maureen K, Katsanis, Nicholas, Robins, Diane M, Silverman, Jill L, Singh, Karun K, Wevrick, Rachel, Taylor, Margot J, Hammill, Christopher, Anagnostou, Evdokia, Pfeiffer, Brad E, Stoodley, Catherine J, Lerch, Jason P, du Lac, Sascha, and Tsai, Peter T

Subjects
Mental Health, Intellectual and Developmental Disabilities (IDD), Autism, Pediatric, Neurosciences, Brain Disorders, Basic Behavioral and Social Science, Behavioral and Social Science, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, 1.1 Normal biological development and functioning, Mental health, Animals, Autism Spectrum Disorder, Cerebellum, Male, Mice, Mice, Mutant Strains, Neural Pathways, Prefrontal Cortex, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Cerebellar dysfunction has been demonstrated in autism spectrum disorders (ASDs); however, the circuits underlying cerebellar contributions to ASD-relevant behaviors remain unknown. In this study, we demonstrated functional connectivity between the cerebellum and the medial prefrontal cortex (mPFC) in mice; showed that the mPFC mediates cerebellum-regulated social and repetitive/inflexible behaviors; and showed disruptions in connectivity between these regions in multiple mouse models of ASD-linked genes and in individuals with ASD. We delineated a circuit from cerebellar cortical areas Right crus 1 (Rcrus1) and posterior vermis through the cerebellar nuclei and ventromedial thalamus and culminating in the mPFC. Modulation of this circuit induced social deficits and repetitive behaviors, whereas activation of Purkinje cells (PCs) in Rcrus1 and posterior vermis improved social preference impairments and repetitive/inflexible behaviors, respectively, in male PC-Tsc1 mutant mice. These data raise the possibility that these circuits might provide neuromodulatory targets for the treatment of ASD.

Published
2020

30. Effect of Mechanical Damage on Tritium Permeability Resistance of FeAl/Al 2 O 3 Coating on 316L Stainless Steel.

Author

Li, Yinghong, Nie, Lihong, Meng, Fantao, Hu, Haixiang, Zong, Sifan, Hong, Zhihao, Wang, Long, Li, Changzheng, Ren, Qisen, and Hu, Jing

Abstract

Depositing a tritium permeation barrier on the surface of materials is a key method for reducing tritium permeability. During actual operational processes, the surface of the tritium permeation barrier may experience mechanical damage, such as spalling and scratches. The hydrogen permeability resistance of the coating will degrade due to such forms of mechanical damage. It is a significant engineering challenge to evaluate the impact of these damages on the coating's tritium resistance. In this experiment, the mechanical damage to the FeAl/Al2O3 tritium permeation barrier on 316L stainless steel was simulated through scratching, debonding, and thermal shock. Subsequently, a hydrogen isotope gas drive permeation (GDP) test was conducted. The influence of the degree of mechanical damage on the coating's tritium permeation behavior was assessed and discussed. The results indicate that, under the same damage mechanism, the coating's tritium permeability resistance is positively correlated with the integrity of the coating. Additionally, the impact of scratches on the coating surface is more severe than that of other damage mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Cryptotanshinone ameliorates CUS-induced depressive-like behaviors in mice

Author

Wang Kaixin, Zhai Qingling, Wang Sanwang, Li Qiongyu, Liu Jing, Meng Fantao, Wang Wentao, Zhang Jinjie, Wang Dan, Zhao Di, Liu Cuilan, Dai Juanjuan, Li Chen, Cui Minghu, and Chen Jinbo

Subjects
cryptotanshinone, depression, neuroinflammation, microglial polarization, neurogenesis, bdnf, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Cryptotanshinone (CPT), a natural quinoid diterpene, isolated from Salvia miltiorrhiza, has shown various pharmacological properties. However, its effect on chronic unpredictable stress (CUS)-induced depression phenotypes and the underlying mechanism remain unclear. Therefore, the aim of this study was to investigate whether CPT could exert an antidepressant effect.

Published
2021
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40. Study on mechanical and thermal properties of coir fibers reinforced thermoplastic starch/poly(butylene adipate‐co‐terephthalate) composites.

Author

Tang, Xianggang, Tan, Jianwei, Hu, Yongxiang, Su, Chengzhuang, Liu, Zhekun, Wei, Chuncheng, Dong, Shuhua, and Meng, Fantao

Subjects
BIODEGRADABLE materials, GLASS transition temperature, INJECTION molding, COIR, FLEXURAL strength
Abstract

In this study, a novel biodegradable coir fiber (CF) reinforced thermoplastic starch (TPS) and poly(butylene adipate‐co‐terephthalate) (PBAT) composites (CF/TPS/PBAT) with a constant TPS: PBAT weight ratio of 70:30 and 5, 10, 15, and 20 wt% additions of CF were prepared by the melt blending and injection molding. The effects of fiber content and fiber surface modification on the mechanical and thermal properties of the prepared biocomposites were investigated. The incorporation of fibers effectively enhanced the mechanical and thermal properties of TPS/PBAT blends. Due to the removal of hemicellulose and impurities on the fiber surface after alkali treatment, the interfacial adhesion of the fiber was enhanced, thus improving the compatibility between the fibers and the matrix. At 20 wt% CFs with alkali treatment, the tensile strength exhibited 393% improvement and flexural strength exhibited 536% improvement over TPS/PBAT blends. Thermal analysis showed that the thermal stability, storage modulus, and glass transition temperature of the composites increased with the increase of fiber content. This work is significant for the development of biodegradable materials. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Title Fault Diagnosis of Transmission Network Based on Fusion of Time Sequence and Hierarchical Transitional WFPN

Author

Zhao, Shasha, Lin, Xiaoxiao, Meng, Fantao, Cheng, Xuezhen, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Du, Junping, editor, and Zhang, Weicun, editor

Published
2019
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43. Distribution Network Fault Location Based on Improved Binary Particle Swarm Optimization

Author

Meng, Fantao, Zhao, Shasha, Li, Zhen, Li, Shiguang, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Jia, Yingmin, editor, Du, Junping, editor, and Zhang, Weicun, editor

Published
2019
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44. Dysregulated gene-associated biomarkers for Alzheimer’s disease and aging

Author

Li Min, Geng Rongxin, Li Chen, Meng Fantao, Zhao Hongwei, Liu Jing, Dai Juanjuan, and Wang Xuezhen

Subjects
alzheimer’s disease, aging, differentially expressed genes, blood, hippocampus, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Alzheimer’s disease (AD), the most common type of dementia, is a neurodegenerative disorder with a hidden onset, including difficult early detection and diagnosis. Nevertheless, the new crucial biomarkers for the diagnosis and pathogenesis of AD need to be explored further. Here, the common differentially expressed genes (DEGs) were identified through a comprehensive analysis of gene expression profiles from the Gene Expression Omnibus (GEO) database. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that these DEGs were mainly associated with biological processes, cellular components, and molecular functions, which are involved in multiple cellular functions. Next, we found that 9 of the 24 genes showed the same regulatory changes in the blood of patients with AD compared to those in the GEO database, and 2 of the 24 genes showed a significant correlation with Montreal Cognitive Assessment scores. Finally, we determined that mice with AD and elderly mice had the same regulatory changes in the identified DEGs in both the blood and hippocampus. Our study identified several potential core biomarkers of AD and aging, which could contribute to the early detection, differential diagnosis, treatment, and pathological analysis of AD.

Published
2021
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