Cryptotanshinone ameliorates CUS-induced depressive-like behaviors in mice

Authors :: Wang Kaixin
Zhai Qingling
Wang Sanwang
Li Qiongyu
Liu Jing
Meng Fantao
Wang Wentao
Zhang Jinjie
Wang Dan
Zhao Di
Liu Cuilan
Dai Juanjuan
Li Chen
Cui Minghu
Chen Jinbo
Source :: Translational Neuroscience, Vol 12, Iss 1, Pp 469-481 (2021)
Publication Year :: 2021
Publisher :: De Gruyter, 2021.
Abstract: Cryptotanshinone (CPT), a natural quinoid diterpene, isolated from Salvia miltiorrhiza, has shown various pharmacological properties. However, its effect on chronic unpredictable stress (CUS)-induced depression phenotypes and the underlying mechanism remain unclear. Therefore, the aim of this study was to investigate whether CPT could exert an antidepressant effect.