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4 results on '"Meglio, Annamaria di"'

1. The rare cases of co-occurrences of Down Syndrome Disease and Juvenile Myelomonocytic Leukemia

Author

Buldini, Barbara, primary, Tumino, Manuela, additional, Varotto, Elena, additional, Francescato, Samuela, additional, Peloso, Alberto, additional, Meglio, Annamaria Di, additional, Leszl, Anna, additional, Gabelli, Maria, additional, Cani, Alice, additional, Masetti, Riccardo, additional, Biffi, Alessandra, additional, Sainati, Laura, additional, and Bresolin, Silvia, additional

Published
2023
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3. A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia

Author

Paganin, Maddalena, Buldini, Barbara, Germano, Giuseppe, Seganfreddo, Elena, Meglio, Annamaria di, Magrin, Elisa, Grillo, Francesca, Pigazzi, Martina, Rizzari, Carmelo, Cazzaniga, Giovanni, Khiabanian, Hossein, Palomero, Teresa, Rabadan, Raul, Ferrando, Adolfo A., Basso, Giuseppe, Paganin, M, Buldini, B, Germano, G, Seganfreddo, E, Meglio, A, Magrin, E, Grillo, F, Pigazzi, M, Rizzari, C, Cazzaniga, G, Khiabanian, H, Palomero, T, Rabadan, R, Ferrando, A, and Basso, G

Subjects
Male, MED/03 - GENETICA MEDICA, Hematology, Gene Rearrangement, T-Lymphocyte, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute, Oncology, Recurrence, Child, Preschool, switch lineage, Pediatrics, Perinatology and Child Health, Mutation, Humans, whole-exome sequencing, T-ALL, Gene Deletion, Human
Abstract

A 4-year-old male with the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL) relapsed after 19 months with an acute myeloid leukemia (AML). Immunoglobulin and T-cell receptor gene rearrangements analyses reveal that both leukemias were rearranged with a clonal relationship between them. Comparative genomic hybridization (Array-CGH) and whole-exome sequencing analyses of both samples suggest that this leukemia may have originated from a common T/myeloid progenitor. The presence of homozygous deletion of p16/INK4A, p14/ARF, p15/INK4B, and heterozygous deletion of WT1 locus remained stable in the leukemia throughout phenotypic switch, revealing that this AML can be genetically associated to T-ALL.

Published
2016

4. A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia

Author

Paganin, M, Buldini, B, Germano, G, Seganfreddo, E, Meglio, A, Magrin, E, Grillo, F, Pigazzi, M, Rizzari, C, Cazzaniga, G, Khiabanian, H, Palomero, T, Rabadan, R, Ferrando, A, Basso, G, Paganin, Maddalena, Buldini, Barbara, Germano, Giuseppe, Seganfreddo, Elena, Meglio, Annamaria di, Magrin, Elisa, Grillo, Francesca, Pigazzi, Martina, Rizzari, Carmelo, Cazzaniga, Giovanni, Khiabanian, Hossein, Palomero, Teresa, Rabadan, Raul, Ferrando, Adolfo A., Basso, Giuseppe, Paganin, M, Buldini, B, Germano, G, Seganfreddo, E, Meglio, A, Magrin, E, Grillo, F, Pigazzi, M, Rizzari, C, Cazzaniga, G, Khiabanian, H, Palomero, T, Rabadan, R, Ferrando, A, Basso, G, Paganin, Maddalena, Buldini, Barbara, Germano, Giuseppe, Seganfreddo, Elena, Meglio, Annamaria di, Magrin, Elisa, Grillo, Francesca, Pigazzi, Martina, Rizzari, Carmelo, Cazzaniga, Giovanni, Khiabanian, Hossein, Palomero, Teresa, Rabadan, Raul, Ferrando, Adolfo A., and Basso, Giuseppe

Abstract

A 4-year-old male with the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL) relapsed after 19 months with an acute myeloid leukemia (AML). Immunoglobulin and T-cell receptor gene rearrangements analyses reveal that both leukemias were rearranged with a clonal relationship between them. Comparative genomic hybridization (Array-CGH) and whole-exome sequencing analyses of both samples suggest that this leukemia may have originated from a common T/myeloid progenitor. The presence of homozygous deletion of p16/INK4A, p14/ARF, p15/INK4B, and heterozygous deletion of WT1 locus remained stable in the leukemia throughout phenotypic switch, revealing that this AML can be genetically associated to T-ALL.

Published
2016

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