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A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia
- Source :
- Pediatric bloodcancer. 63(9)
- Publication Year :
- 2016
-
Abstract
- A 4-year-old male with the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL) relapsed after 19 months with an acute myeloid leukemia (AML). Immunoglobulin and T-cell receptor gene rearrangements analyses reveal that both leukemias were rearranged with a clonal relationship between them. Comparative genomic hybridization (Array-CGH) and whole-exome sequencing analyses of both samples suggest that this leukemia may have originated from a common T/myeloid progenitor. The presence of homozygous deletion of p16/INK4A, p14/ARF, p15/INK4B, and heterozygous deletion of WT1 locus remained stable in the leukemia throughout phenotypic switch, revealing that this AML can be genetically associated to T-ALL.
- Subjects :
- Male
MED/03 - GENETICA MEDICA
Hematology
Gene Rearrangement, T-Lymphocyte
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Myeloid, Acute
Oncology
Recurrence
Child, Preschool
switch lineage
Pediatrics, Perinatology and Child Health
Mutation
Humans
whole-exome sequencing
T-ALL
Gene Deletion
Human
Subjects
Details
- ISSN :
- 15455017
- Volume :
- 63
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Pediatric bloodcancer
- Accession number :
- edsair.pmid.dedup....c7fa69a66813729923ccae1147906e7d