1. The Impact of Therapeutic Hypothermia Used to Treat Anoxic Brain Injury After Cardiopulmonary Resuscitation on Organ Donation Outcomes
- Author
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Markeith Pilot, Nikole Neidlinger, Tahnee Groat, Xiang Gao, Darren J. Malinoski, Megan Crutchfield, Charles Wright, Mitchell B. Sally, Madhukar S. Patel, and Maxwell Witt
- Subjects
Adult ,Male ,medicine.medical_treatment ,Delayed Graft Function ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Hypothermia, Induced ,Medicine ,Humans ,In patient ,Organ donation ,Cardiopulmonary resuscitation ,Prospective Studies ,Hypoxia, Brain ,Anoxic brain injury ,business.industry ,030208 emergency & critical care medicine ,Hypothermia ,Middle Aged ,Kidney Transplantation ,Cardiopulmonary Resuscitation ,Tissue Donors ,Anesthesiology and Pain Medicine ,Anesthesia ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Therapeutic hypothermia (TH) is clinically used to improve neurologic outcomes in patients with anoxic brain injury after cardiopulmonary resuscitation (CPR). For patients that regress and become organ donors after neurologic determination of death (DNDDs), the impact of TH received before determination of death on organ donation outcomes remains unknown. A prospective observational study of all adult DNDDs that received CPR and had anoxia as a cause of death from March 2013 to December 2014 was conducted across 20 organ procurement organizations (OPOs) in the United States. Main outcome measures included organs transplanted per donor (OTPD), specific organ transplantation rates, and recipient graft outcomes. One thousand ninety eight DNDDs met inclusion criteria, with 46% having received TH before determination of death. DNDDs with hypothermia before death had a similar number of OTPD (2.74 vs. 2.69
- Published
- 2019