470,855 results on '"Medicine, Experimental"'
Search Results
2. Electronic Health Record Data for Lyme Disease Surveillance, Massachusetts, USA, 2017-2018
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Nagavedu, Kshema, Eberhardt, Karen, Willis, Sarah, Morrison, Monica, Ochoa, Aileen, Soliva, Susan, Scotland, Sarah, Cocoros, Noelle M., Callahan, Myfanwy, Randall, Liisa M., Brown, Catherine M., and Klompas, Michael
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Massachusetts -- Health aspects ,Medical research ,Medicine, Experimental ,Sentinel health events -- Methods -- Technology application ,Medical records -- Usage ,Electronic records -- Usage ,Lyme disease -- Research ,Algorithms -- Usage -- Health aspects ,Health ,Algorithm ,Technology application ,Usage ,Research ,Methods ,Health aspects - Abstract
Lyme disease, caused by infection with the bacterium Borrelia burgdorferi, is the most common vectorborne illness in the United States and is steadily affecting an expanding area of the country [...]
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- 2024
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3. Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence, Japan, 2023
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Kinoshita, Ryo, Miyamoto, Sho, Sakuraba, Shoko, Sugihara, Jun, Suzuki, Motoi, Suzuki, Tadaki, and Yoneoka, Daisuke
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Medical research ,Medicine, Experimental ,Viral antibodies -- Testing ,Prevalence studies (Epidemiology) -- Methods ,Antibodies -- Testing ,Company distribution practices ,Health - Abstract
Before the Omicron variant emerged, 6 months of age have been recommended to receive COVID-19 vaccines in Japan, where mRNA vaccines (Pfizer-BioNTech, https://www.pfizer.com; Moderna, https://www. modernatx.com) are predominantly used. Seroepidemiologic [...]
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- 2024
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4. Effect of Myxoma Virus Species Jump on Iberian Hare Populations
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Cardoso, Beatriz, Garcia-Bocanegra, Ignacio, Queiros, Joao, Fernandez-Lopez, Javier, Alves, Paulo C., and Acevedo, Pelayo
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Medical research ,Medicine, Experimental ,Myxoma virus -- Distribution ,Animal populations -- Evaluation ,Company distribution practices ,Health - Abstract
In July 2018, after 60 years of endemic circulation in European wild rabbits (Oryctolagus cuniculus), myxoma virus (MYXV) jumped to the Iberian hare (Lepus granatensis) (1). This species jump resulted [...]
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- 2024
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5. Novel Avian Influenza A(H5N6) Virus in Wild Birds, South Korea, 2023
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Cho, Andrew Yong, Si, Young-Jae, Kim, Dong-Ju, Seo, Ye-Ram, Lee, Dong-Yeop, Kim, Daehun, Lee, Dongbin, Son, Yaemoon, Jeong, Hyesung, Song, Chang-Seon, and Lee, Dong-Hun
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Avian influenza -- Genetic aspects -- Diagnosis ,Glycoproteins -- Health aspects ,Medical research ,Medicine, Experimental ,Sentinel health events -- Methods ,Health - Abstract
Infection caused by highly pathogenic avian influenza viruses (HPAIVs) have caused major economic losses in the poultry industry and pose a serious threat to public health. The A/goose/ Guangdong/1/1996 (gs/GD) [...]
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- 2024
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6. Zoonotic Ancylostoma ceylanicum Infection in Coyotes from Guanacaste Conservation Area, Costa Rica, 2021
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Zendejas-Heredia, Patsy A., Robleto-Quesada, Joby, Solano, Alberto, Rojas, Alicia, and Colella, Vito
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Medical research ,Medicine, Experimental ,Sentinel health events -- Methods ,Zoonoses -- Diagnosis -- Care and treatment ,Coyotes -- Diseases ,Hookworm disease -- Diagnosis -- Care and treatment ,Health - Abstract
The zoonotic hookworm Ancylostoma ceylanicum infects canids, felids, and humans in tropical regions of the world (2,2). Heavy infections may cause iron-deficiency anemia and bloody diarrhea as a result of [...]
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- 2024
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7. Human Passage of Schistosoma incognitum, Tamil Nadu, India, and Review of Autochthonous Schistosomiasis, South Asia
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Ajjampur, Sitara S.R., Sarkar, Rajiv, and Bradbury, Richard S.
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Medical research ,Medicine, Experimental ,Schistosomiasis -- Diagnosis -- Care and treatment ,Disease transmission -- Evaluation ,Public health administration -- Evaluation ,Health ,Diagnosis ,Care and treatment ,Evaluation - Abstract
In 1926, A.C. Chandler described "a new schistosome infection of man" based on the presence of distinctive terminal spined schistosome eggs from 2 human fecal samples collected in Krishnanagar, West [...]
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- 2024
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8. Emergence of Group B Streptococcus Disease in Pigs and Porcupines, Italy
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Garbarino, Chiara Anna, Bariselli, Simone, Pupillo, Giovanni, Bassi, Patrizia, Luppi, Andrea, Taddei, Roberta, Reggiani, Alessandro, Massella, Elisa, Ricchi, Matteo, Carra, Elena, and Zadoks, Ruth N.
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Animals -- Diseases ,Medical research ,Medicine, Experimental ,Host-bacteria relationships ,Streptococcal infections -- Distribution ,Company distribution practices ,Health - Abstract
Streptococcus agalactiae (group B Streptococcus [GBS]) is a major pathogen of humans, cattle, aquatic species, and camels (2-4). GBS has been detected in pork but has not been associated with [...]
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- 2024
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9. Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China
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Liu, Yang, Chen, Yuhua, Yang, Zhiyi, Lin, Yaozhong, Fu, Siyuan, Chen, Junhong, Xu, Lingyu, Liu, Tengfei, Niu, Beibei, Huang, Qiuhong, Liu, Haixia, Zheng, Chaofeng, Liao, Ming, and Jia, Weixin
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Glycoproteins -- Health aspects ,Medical research ,Medicine, Experimental ,Influenza -- Genetic aspects -- Prevention ,Viral vaccines -- Testing ,Health - Abstract
From early 2013 through October 2017, a total of 5 outbreaks of avian influenza A(H7N9) virus infection occurred, resulting in 616 human deaths (1). In particular, the fifth wave of [...]
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- 2024
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10. Carbapenem-Resistant and Extended-Spectrum [beta]-Lactamase-Producing Enterobacterales in Children, United States, 2016-2020
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Grome, Heather N., Grass, Julian E., Duffy, Nadezhda, Bulens, Sandra N., Ansari, Uzma, Campbell, Davina, Lutgring, Joseph D., Gargis, Amy S., Masters, Thao, Kent, Alyssa G., McKay, Susannah L., Smith, Gillian, Wilson, Lucy E., Vaeth, Elisabeth, Evenson, Bailey, Dumyati, Ghinwa, Tsay, Rebecca, Phipps, Erin, Flores, Kristina, Wilson, Christopher D., Czaja, Christopher A., Johnston, Helen, Janelle, Sarah J., Lynfield, Ruth, OMalley, Sean, Vagnone, Paula Snippes, Maloney, Meghan, Nadle, Joelle, and Guh, Alice Y.
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Medical research ,Medicine, Experimental ,Enterobacteriaceae infections -- Drug therapy -- Diagnosis ,Drug resistance in microorganisms -- Testing ,Communicable diseases in children -- Drug therapy -- Diagnosis ,Health - Abstract
Medscape CME Activity In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is jointly accredited with commendation [...]
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- 2024
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11. Chest Radiograph Screening for Detecting Subclinical Tuberculosis in Asymptomatic Household Contacts, Peru
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Tan, Qi, Huang, Chuan-Chin, Becerra, Mercedes C., Calderon, Roger, Contreras, Carmen, Lecca, Leonid, Jimenez, Judith, Yataco, Rosa, Galea, Jerome T., Feng, Jia-Yih, Pan, Sheng-Wei, Tseng, Yen-Han, Huang, Jhong-Ru, Zhang, Zibiao, and Murray, Megan B.
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Medical research ,Medicine, Experimental ,Epidemiologic methods -- Research ,Tuberculosis -- Diagnosis -- Care and treatment ,Radiography, Medical -- Usage ,Public health administration -- Evaluation ,Health - Abstract
Recognizing the key role early detection plays in interrupting further tuberculosis (TB) transmission, the World Health Organization (WHO) has emphasized the need for global investment in that area. In line [...]
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- 2024
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12. Deciphering Unexpected Vascular Locations of Scedosporium spp. and Lomentospora prolificans Fungal Infections, France
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Vignals, Carole, Emmerich, Joseph, Begueret, Hugues, Garcia-Hermoso, Dea, Martin-Blondel, Guillaume, Angoulvant, Adela, Blez, Damien, Bruneval, Patrick, Cassaing, Sophie, Catherinot, Emilie, Cahen, Pierre, Molucon-Chabrot, Cecile, Chevenet, Carole, Delhaes, Laurence, Escaut, Lelia, Faruch, Marie, Grenouillet, Frederic, Larosa, Fabrice, Limousin, Lucie, Longchampt, Elisabeth, Mellot, Francois, Nourrisson, Celine, Bougnoux, Marie-Elisabeth, Lortholary, Olivier, Roux, Antoine, Rozenblum, Laura, Puges, Mathilde, Lanternier, Fanny, and Bronnimann, Didier
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Medical research ,Medicine, Experimental ,Arteritis -- Diagnosis -- Care and treatment ,Mycoses -- Physiological aspects ,Health - Abstract
Scedosporium spp. and Lomentospora prolificans are non-Aspergillus filamentous fungi causing increasingly recognized invasive fungal disease (IFD) in both immunocompromised and immunocompetent patients (2,2). Scedosporium spp. comprise S. apiospermum complex species, [...]
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- 2024
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13. Severe Human Parainfluenza Virus Community- and Healthcare-Acquired Pneumonia in Adults at Tertiary Hospital, Seoul, South Korea, 2010-2019
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Park, Joung Ha, Hong, Sang-Bum, Huh, Jin Won, Jung, Jiwon, Kim, Min Jae, Chong, Yong Pil, Sung, Heungsup, Do, Kyung Hyun, Kim, Sung-Han, Lee, Sang-Oh, Kim, Yang Soo, Lim, Chae-Man, Koh, Younsuck, and Choi, Sang-Ho
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Medical research ,Medicine, Experimental ,Bacterial pneumonia -- Development and progression -- Care and treatment ,Cross infection -- Prevention ,Influenza -- Complications and side effects -- Care and treatment ,Pneumonia -- Development and progression -- Care and treatment ,Nosocomial infections -- Prevention ,Health ,Care and treatment ,Prevention ,Complications and side effects ,Development and progression - Abstract
Human parainfluenza virus (HPIV) is a major cause of acute respiratory tract infections, such as croup in children and pneumonia in immunocompromised patients (1). HPIV is a single-stranded, enveloped RNA [...]
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- 2024
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14. Overuse of antibiotics for urinary tract infections in pregnant refugees, Lebanon/Surconsommation d'antibiotiques en cas d'infections urinaires chez les refugiees enceintes au Liban/Abuso de antibioticos para infecciones urinarias entre las refugiadas embarazadas en el Libano
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Kady, Christine Al, Moussally, Krystel, Chreif, Wafaa, Farra, Anna, Caluwaerts, Severine, Wertheim, Heiman, Soukarieh, ounia, Gomez, Fabiola Gordillo, Dibiasi, Johanna, and Lenglet, Annick
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Urinary tract infections -- Research ,Medical research ,Medicine, Experimental ,Refugees -- Research ,Clinics -- Research ,Laboratories -- Research ,Pregnant women -- Research ,Reproductive health -- Research ,Antibiotics -- Research ,Refugee camps -- Research ,Health ,Doctors Without Borders ,World Health Organization - Abstract
Objective To determine whether adding urine culture to urinary tract infection diagnosis in pregnant women from refugee camps in Lebanon reduced unnecessary antibiotic use. Methods We conducted a prospective, cross-sectional study between April and June 2022 involving pregnant women attending a Medecins Sans Frontieres sexual reproductive health clinic in south Beirut. Women with two positive urine dipstick tests (i.e. a suspected urinary tract infection) provided urine samples for culture. Bacterial identification and antimicrobial sensitivity testing were conducted following European Committee on Antimicrobial Susceptibility Testing guidelines. We compared the characteristics of women with positive and negative urine culture findings and we calculated the proportion of antibiotics overprescribed or inappropriately used. We also estimated the cost of adding urine culture to the diagnostic algorithm. Findings The study included 449 pregnant women with suspected urinary tract infections: 18.0% (81/449) had positive urine culture findings. If antibiotics were administered following urine dipstick results alone, 368 women would have received antibiotics unnecessarily: an overprescription rate of 82% (368/449). If administration was based on urine culture findings plus urinary tract infection symptoms, 144 of 368 women with negative urine culture findings would have received antibiotics unnecessarily: an overprescription rate of 39.1% (144/368). The additional cost of urine culture was 0.48 euros per woman. Conclusion A high proportion of pregnant women with suspected urinary tract infections from refugee camps unnecessarily received antibiotics. Including urine culture in diagnosis, which is affordable in Lebanon, would greatly reduce antibiotic overprescription. Similar approaches could be adopted in other regions where microbiology laboratories are accessible. Objectif Determiner si l'ajout d'une uroculture pour diagnostiquer une infection urinaire chez les femmes enceintes dans les camps de refugies au Liban permet d'eviter de recourir inutilement aux antibiotiques. Methodes Nous avons mene une etude transversale prospective entre avril et juin 2022 sur des femmes enceintes frequentant une clinique de sante sexuelle et reproductive geree par Medecins Sans Frontieres dans le sud de Beyrouth. Les femmes presentant deux tests positifs par bandelette urinaire (c'est-a-dire souffrant potentiellement d'une infection urinaire) ont fourni des echantillons d'urine pour culture. Les tests d'identification bacterienne et de sensibilite aux antimicrobiens ont ete effectues conformement aux lignes directrices du Comite europeen des antibiogrammes. Nous avons compare les caracteristiques des femmes ayant obtenu des resultats d'uroculture positifs et negatifs puis nous avons calcule la proportion d'antibiotiques surprescrits ou utilises de fagon inappropriee. Enfin, nous avons estime combien couterait l'ajout d'une uroculture a l'algorithme de diagnostic. Resultats Letude a porte sur 449 femmes enceintes susceptibles de souffrir d'infections urinaires: 18,0% (81/449) ont obtenu des resultats positifs lors de l'uroculture. Si des antibiotiques avaient ete administres uniquement sur la base des resultats aux tests par bandelette urinaire, 368 femmes en auraient regu sans en avoir besoin, ce qui equivaut a un taux de surprescription de 82% (368/449). S'ils avaient ete administres sur la base des resultats de l'uroculture ainsi que des symptomes d'infection urinaire, 144 des 368 femmes ayant obtenu des resultats negatifs auraient regu des antibiotiques sans en avoir besoin, ce qui represente un taux de surprescription de 39,1% (144/368). La mise en place de l'uroculture a engendre un cout supplemental de 0,48 euro par femme. Conclusion Dans les camps de refugies, une proportion elevee de femmes enceintes potentiellement atteintes d'infections urinaires se sont vu prescrire des antibiotiques sans que ce ne soit necessaire. Inclure dans le diagnostic une uroculture, proposee a prix abordable au Liban, permettrait de reduire considerablement leur surprescription. Des approches similaires pourraient en outre etre adoptees dans d'autres regions ou des laboratoires de microbiologie sont accessibles. Objetivo Determinar si la adicion del urocultivo al diagnostico de infeccion urinaria en mujeres embarazadas de campos de refugiados en Libano redujo el uso innecesario de antibioticos. Metodos Entre abril y junio de 2022, se realizo un estudio prospectivo transversal en el que participaron mujeres embarazadas que acudian a una clinica de salud reproductiva sexual de Medicos Sin Fronteras en el sur de Beirut. Las mujeres con dos pruebas de tira reactiva en orina positivas (es decir, sospecha de infeccion urinaria) proporcionaron muestras de orina para cultivo. La identificacion bacteriana y las pruebas de sensibilidad antimicrobiana se realizaron siguiendo las directrices del Comite Europeo sobre Pruebas de Susceptibilidad Antimicrobiana. Se compararon las caracteristicas de las mujeres con urocultivos positivos y negativos, y se calculo el porcentaje de antibioticos prescritos en exceso o utilizados de forma inadecuada. Tambien se calculo el coste de anadir el urocultivo al algoritmo diagnostico. Resultados En el estudio participaron 449 mujeres embarazadas con sospecha de infeccion urinaria: el 18,0% (81/449) tuvieron resultados positivos en el urocultivo. Si la administracion de antibioticos se basaba unicamente en los resultados de la tira reactiva de orina, 368 mujeres habrian recibido antibioticos sin necesidad: una tasa de prescripcion excesiva del 82% (368/449). Si la administracion se basaba en los resultados del urocultivo mas los sintomas de infeccion urinaria, 144 de las 368 mujeres con resultados negativos del urocultivo habrian recibido antibioticos sin necesidad: una tasa de sobreprescripcion del 39,1% (144/368). El coste adicional del urocultivo fue de 0,48 [euro] por mujer. Conclusion Un alto porcentaje de embarazadas con sospecha de infeccion urinaria procedentes de campos de refugiados recibieron antibioticos innecesariamente. La inclusion del urocultivo en el diagnostico, asequible en Libano, reduciria en gran medida la prescripcion excesiva de antibioticos. Se podrian adoptar enfoques similares en otras regiones donde se pueda acceder a los laboratorios de microbiologia. [phrase omitted], Introduction Inappropriate antibiotic use is one of the main drivers of anti-microbial resistance. (1) The standard of care for pregnant women is to give antibiotics to prevent complications, particularly in [...]
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- 2024
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15. Polyglobulie essentielle et hypertension portale non cirrhotique diagnostiquees en cours de grossesse
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Frank, Cairina, Amily, Noor, Kelly, Erin, Kimpton, Miriam, Villeneuve, Pierre, and O'Meara, Paloma
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Portal hypertension -- Physiological aspects -- Case studies -- Diagnosis ,Medical research ,Medicine, Experimental ,Pregnancy -- Health aspects -- Case studies ,Polycythemia -- Physiological aspects -- Case studies -- Diagnosis ,Health - Abstract
Une femme de 35 ans (2 gestations nullipares, 1 fausse couche) a consulte a notre clinique d'obstetrique a 30 semaines et 1 jour d'une gestation par fecondation in vitro, pour [...]
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- 2024
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16. The happiness trap
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Feehly, Conor
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Medical research ,Medicine, Experimental ,Happiness -- Research ,Attributional biases -- Research ,Positive thinking (Psychology) -- Research ,Business ,Science and technology ,Research - Abstract
The idea that we should always look on the bright side has gone too far and may now by damaging our well-being, finds Conor Feehly ARE you struggling with low [...]
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- 2024
17. THE WAR ON CHRONIC PAIN: INSTEAD OF A SINGLE CURE, RESEARCHERS ARE NOW LOOKING FOR A MULTIPRONGED APPROACH TO MANAGING EVERYDAY ACHES
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Migala, Jessica
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Medical research ,Medicine, Experimental ,Chronic pain ,Backache ,Company business management ,General interest - Abstract
Chances are, right now, you're in some sort of pain. Maybe your back aches, or arthritis is hurting your hands or knee pain is hobbling your walk. Maybe you're dealing [...]
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- 2024
18. American Urological Association Annual Meeting San Antonio, Texas
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Broderick, Jason M., Pelosci, Ariana, and Serani, Sabrina
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Medical research ,Medicine, Experimental ,BCG vaccines ,BCG ,Business ,Health care industry - Abstract
May 3-6, 2024 NADOFARAGENE FIRADENOVEC SUSTAINS EFFICACY IN NMIBC AT 5-YEAR FOLLOW-UP The gene therapy nadofaragene firadenovec-vncg (Adstiladrin) continued to demonstrate durable clinical activity in patients with high-risk, BCG-unresponsive non-muscle-invasive [...]
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- 2024
19. Status Check: Science & Sustainability
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Medical research ,Medicine, Experimental ,Ecological footprint ,Environmental sustainability ,General interest ,Health - Abstract
Industry leaders discuss the progress and path forward for the clinical trials enterprise in meeting its environmental mandate. On May 16, 2024, Applied Clinical Trials held a roundtable event focused [...]
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- 2024
20. WHO position paper on dengue vaccines--May 2024/Note de synthese: position de l'OMS sur les vaccines contre la dengue--mai 2024
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Biological products industry ,Vaccination ,Medical research ,Medicine, Experimental ,Dengue -- Development and progression ,Medical policy ,B cells ,Public health ,Government ,Health ,University of London. Imperial College of Science and Technology - Abstract
Introduction In accordance with its mandate to provide normative guidance to Member States on health policy matters, WHO issues a series of regularly updated position papers on vaccines and combinations [...]
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- 2024
21. Factors associated with the intestinal health of bariatricpatients in the context of the covid-19 pandemic in brazil/FATORES ASSOCIADOS A SAUDE INTESTINAL DE PACIENTES BARIATRICOS NO CONTEXTO DA PANDEMIA DA COVID-19 NO BRASIL
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Brasil, Thalya Cristina Ribeiro, Gomes, Bruna Gusmao, Conceicao, Weany Jacqueline Costa da, Figueira, Marcela de Souza, Gomes, Daniela Lopes, and Costa, Vanessa Vieira Lourenco
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- 2024
22. Antimicrobial Resistance as Risk Factor for Recurrent Bacteremia after Staphylococcus aureus, Escherichia coli, or Klebsiella spp. Community-Onset Bacteremia
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Abbara, Salam, Guillemot, Didier, Smith, David R.M., Oualydy, Salma El, Kos, Maeva, Poret, Cecile, Breant, Stephane, Brun- Buisson, Christian, and Watier, Laurence
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Medical research ,Medicine, Experimental ,Community-acquired infections -- Statistics -- Risk factors ,Drug resistance in microorganisms -- Research ,Diseases -- Relapse ,Klebsiella infections -- Statistics -- Risk factors ,Staphylococcus aureus infections -- Statistics -- Risk factors ,Bacteremia -- Statistics -- Risk factors ,Health - Abstract
Antimicrobial resistance (AMR) is a major global health issue, associated with an estimated 4.95 million deaths worldwide in 2019 (2,2). Although the effects of AMR on clinical and economic outcomes [...]
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- 2024
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23. Influencia del marcaje previo en las complicaciones post colocación del catéter de diálisis peritoneal
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Menéndez-Servide, Fabiola, Fernández-Pérez, Mónica, Suárez-Álvarez, Adela, Blanco-Sierra, Jessica, Pasarón-Alonso, Magdalena, and Núñez-Moral, Miguel
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- 2024
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24. Diseño de estrategias para la atención integral en una paciente con barrera idiomática en tratamiento con hemodiálisis: a propósito de un caso
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Hussein-Cobos, Sara, Calvo-Báscones, Miriam, and Barroso-San Juan, Lourdes
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- 2024
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25. CONSUMER MEAT SAFETY KNOWLEDGE AND HYGIENE PRACTICES IN A VETERINARY DISEASE-CONTROLLED AREA OF SOUTH AFRICA
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Nkosi, D.V., Bekker, J.L., and Hoffman, L.C.
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Medicine, Preventive ,Medical research ,Medicine, Experimental ,Consumer protection -- Methods ,Food -- Safety and security measures ,Sanitation, Household -- Forecasts and trends ,Meat -- Health aspects ,Preventive health services ,Market trend/market analysis ,Agricultural industry ,Food/cooking/nutrition ,Health ,World Health Organization -- Powers and duties - Abstract
Consumers' practices and knowledge play a significant role in ensuring meat safety and hygiene application. This is important in an environment where the slaughter and release of such meat is restricted and not always controlled and monitored. This could have been contributed by the lack of slaughter facilities; the controlled movement of live animal restrictions applicable in a typical veterinary diseases-controlled area. The aim of this investigation was to identify meat hygiene practices and general meat safety knowledge applied by consumers of central Bushbuckridge, South Africa. Structured interviews (n=81) were conducted with consumers observed purchasing meat from local meat supply centres. Data analysis was achieved by SAS Statistical software (Version 26) SAS and graphs were drawn using MS Excel 2020. The majority (84.2%, [sigma]=29.4) of the consumers indicated that meat supplied in the region were from registered facilities. The general belief amongst the consumers was that routine hygiene inspection was conducted by authorities at all meat distributing or butchery facilities (74.1%, [sigma]=39.7). None of the facilities or/and butcheries in the study area was registered and therefore, no formal regulated practices could have been conducted. Slaughter and distribution of meat within the area were seen as a good business by 78.6%, [sigma]=18.9 of the consumers, and as a result, the consumers did not have a problem with widespread slaughter and release of this meat to the public outside of those facilities. The extent of hygiene application practices at household level varied. These included the assurance that perishable products were properly handled after purchase (84.1%, [sigma]=8.3), and the handling or transportation of sourced meat did not comply with cold chain management prescripts (39.9%, [sigma]=44.9). The likelihood of consumers feeling the same about meat hygiene concerns and practices is undoubtedly low as represented by a high standard deviation ([sigma]) of the responses. These results show that consumers were relying on authorities for meat safety assurances. This ought to caution authorities on consumer practices and needed interventions such as animal movement policies enforcement. The adoption of such policies by consumers lies with the development and rollout of consumer awareness and meat safety assurances training programs. Key words: abattoir, consumer practices, illegal slaughter, meat safety, meat hygiene, INTRODUCTION Article 11(1) of the Covenant of the United Nations (2012) affirms that everybody has a right to access sufficient and safe food including meat [1]. This resolution clarifies that [...]
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- 2024
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26. Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan
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Sada, Ryuichi Minoda, Matsuo, Hiroo, Motooka, Daisuke, Kutsuna, Satoshi, Hamaguchi, Shigeto, Yamamoto, Go, and Ueda, Akiko
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Nucleotide sequencing ,Blood -- Medical examination ,Medical research ,Medicine, Experimental ,Genomics ,DNA sequencing ,Metronidazole ,Genomes ,Imipenem ,Hospital patients ,Disease susceptibility ,Bacteremia ,Health - Abstract
Probiotics have emerged as agents that improve a wide range of conditions and provide essential ingredients for potential health benefits. Probiotics exhibit a diverse array of effects by engaging in [...]
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- 2024
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27. BÃSQUEDA DE ESTRATEGIAS PARA EL ENFRENTAMIENTO AL DETERIORO DE LA SALUD MENTAL EN PACIENTES CON NEUROPATÃA PERIFÃRICA DIABÃTICA BASADA EN PROCESO JERÃRQUICO ANALÃTICO
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Chacón, Lisbeth Reales, Zumbana, Lizbeth Carolina Eugenio, Flores-Hernández, Verónica, Moposita, Angela Campos, and Pastor, Victoria EspÃn
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- 2024
28. Effets du programme << Des mots pour les maux >> aupres d'eleves a risque ou presentant une dyslexie : une etude pilote
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Tousignant, Fanny Maude Turcotte, Parent, Veronique, Dupuis, Gilles, and Guay, Marie-Claude
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Medical research ,Medicine, Experimental ,Dyslexia ,Learning disabled ,Education - Abstract
This exploratory study investigated the outcomes of the program 'Des mots pour les maux', a program adapted to French and aimed at re-educating different components of written language on graphophonological correspondences and spelling representations with six students with dyslexia or at risk of presenting such disorder. The study is divided into 2 phases which 6 measures are taken: Phase 1 (at the beginning of the study, and 3 and 6 weeks after standard orthopedagogical interventions) and phase 2 (8 weeks, 16 weeks and 24 weeks after introducing the program tested) in order to assess the skills before and after the introduction of the program. The results suggest some improvement regarding phonological correspondences in reading and, more importantly, orthographic representations in reading and spelling 16 weeks after using the program. This study has thus indicated that dyslexic or at-risk students could benefit from this program 'Des mots pour les maux'. Keywords: Dyslexia, reading and spelling interventions, dual-route cascaded model, reading, spelling La presente etude exploratoire evalue les effets du programme Des mots pour les maux : un programme adapte au francais et visant la reeducation de differentes composantes du langage ecrit sur les correspondances graphophonologiques et les representations orthographiques, aupres de six eleves ayant une dyslexie ou a risque de presenter un tel trouble. L'etude se deroule en 2 phases durant lesquelles 6 mesures sont prises : phase 1 (au debut de l'etude, et apres 3 et 6 semaines d'orthopedagogie habituelle) et phase 2 (apres 8, 16 et 24 semaines du programme teste), afin d'evaluer les competences avant et apres l'introduction du programme. Les resultats semblent indiquer que le programme ameliore en partie les correspondances graphophonologiques en lecture, et plus particulierement les representations orthographiques en lecture et en orthographe apres 16 semaines d'intervention. Cette etude demontre ainsi que les eleves a risque de presenter une dyslexie ou ayant une dyslexie pourraient tirer profit du programme. Mots-cles : dyslexie, programmes reeducatifs, modele cognitif a double voie, decodage, orthographe, Introduction La dyslexie est un trouble neurodeveloppemental qui affecte la capacite a apprendre a lire et a ecrire, plus particulierement sur le plan du decodage de la lecture et de [...]
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- 2024
29. Mumps vaccines/Vaccins antiourliens
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Biological products industry ,Vaccination ,Medical research ,Medicine, Experimental ,Medical policy ,Public health ,Vaccines ,Government ,Health ,World Health Organization - Abstract
Introduction In accordance with its mandate to provide normative guidance to Member States on health policy matters, WHO issues a series of regularly updated position papers (1) on vaccines and [...]
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- 2024
30. Advances in the understanding of the pathophysiology of schizophrenia and bipolar disorder through induced pluripotent stem cell models
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Perrottelli, Andrea, Marzocchi, Francesco Flavio, Caporusso, Edoardo, Giordano, Giulia Maria, Giuliani, Luigi, Melillo, Antonio, Pezzella, Pasquale, Bucci, Paola, Mucci, Armida, and Galderisi, Silvana
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Medical research ,Medicine, Experimental ,Schizophrenia ,Stem cells ,GABA ,Neurophysiology ,Health ,Psychology and mental health - Abstract
The pathophysiology of schizophrenia and bipolar disorder involves a complex interaction between genetic and environmental factors that begins in the early stages of neurodevelopment. Recent advancements in the field of induced pluripotent stem cells (iPSCs) offer a promising tool for understanding the neurobiological alterations involved in these disorders and, potentially, for developing new treatment options. In this review, we summarize the results of iPSC-based research on schizophrenia and bipolar disorder, showing disturbances in neurodevelopmental processes, imbalance in glutamatergic-GABAergic transmission and neuromorphological alterations. The limitations of the reviewed literature are also highlighted, particularly the methodological heterogeneity of the studies, the limited number of studies developing iPSC models of both diseases simultaneously, and the lack of in-depth clinical characterization of the included samples. Further studies are needed to advance knowledge on the common and disease-specific pathophysiological features of schizophrenia and bipolar disorder and to promote the development of new treatment options., Introduction Schizophrenia and bipolar disorder are complex and challenging mental disorders, whose etiopathogenesis can be traced back to a complex interaction between genetic and environmental factors that begins at the [...]
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- 2024
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31. Neuroimaging alterations and relapse in early-stage psychosis
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Mihaljevic, Marina, Nagpal, Anisha, Etyemez, Semra, Narita, Zui, Ross, Anna, Schaub, Rebecca, Cascella, Nicola G., Coughlin, Jennifer M., Nestadt, Gerald, Nucifora, Frederik C., Sedlak, Thomas W., Calhoun, Vince D., Faria, Andreia V., Yang, Kun, and Sawa, Akira
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Medical research ,Medicine, Experimental ,Neurons ,Diseases -- Relapse ,Medical colleges ,Health ,Psychology and mental health - Abstract
Background: Recent reports have indicated that symptom exacerbation after a period of improvement, referred to as relapse, in early-stage psychosis could result in brain changes and poor disease outcomes. We hypothesized that substantial neuroimaging alterations may exist among patients who experience relapse in early-stage psychosis. Methods: We studied patients with psychosis within 2 years after the first psychotic event and healthy controls. We divided patients into 2 groups, namely those who did not experience relapse between disease onset and the magnetic resonance imaging (MRI) scan (no-relapse group) and those who did experience relapse between these 2 timings (relapse group). We analyzed 3003 functional connectivity estimates between 78 regions of interest (ROIs) derived from resting-state functional MRI data by adjusting for demographic and clinical confounding factors. Results: We studied 85 patients, including 54 in the relapse group and 31 in the no-relapse group, along with 94 healthy controls. We observed significant differences in 47 functional connectivity estimates between the relapse and control groups after multiple comparison corrections, whereas no differences were found between the no-relapse and control groups. Most of these pathological signatures (64%) involved the thalamus. The Jonckheere-Terpstra test indicated that all 47 functional connectivity changes had a significant cross-group progression from controls to patients in the no-relapse group to patients in the relapse group. Limitations: Longitudinal studies are needed to further validate the involvement and pathological importance of the thalamus in relapse. Conclusion: We observed pathological differences in neuronal connectivity associated with relapse in early-stage psychosis, which are more specifically associated with the thalamus. Our study implies the importance of considering neurobiological mechanisms associated with relapse in the trajectory of psychotic disorders., Introduction The trajectory of psychotic disorders after onset is heterogeneous and many patients show deteriorating courses. (1,2) One of the major determinants of poor prognosis is the occurrence of relapse, [...]
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- 2024
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32. Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study
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Bidot, Samuel, Yin, Jun, Zhou, Pengbo, Zhang, Linsheng, Deeb, Kristin K., Smith, Geoffrey, Hill, Charles E., Xiu, Joanne, Bilen, Mehmet A., Case, Katherine B., Tinsley, Mazie, Carthon, Bradley, and Harik, Lara R.
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Medical research ,Medicine, Experimental ,Adenocarcinoma -- Prognosis -- Genetic aspects ,Metastasis -- Genetic aspects -- Prognosis ,Cancer -- Genetic aspects ,RNA -- Genetic aspects ,African Americans ,Health - Abstract
* Context.--Genetic profiling data of prostatic adenocarcinoma are derived from predominantly White patients. In African Americans, prostatic adenocarcinoma has a poorer prognosis, raising the possibility of distinct genetic alterations. Objective.--To investigate the genomic alterations of prostatic adenocarcinoma metastatic to regional lymph nodes in African American patients, with an emphasis on SPOP mutation. Design.--We retrospectively reviewed African American patients with pN1 prostatic adenocarcinoma managed with radical prostatectomy and lymph node dissection. Comprehensive molecular profiling was performed, and androgen receptor signaling scores were calculated. Results.--Nineteen patients were included. The most frequent genetic alteration was SPOP mutations (5 of 17; 29.4% [95% CI: 10.3-56.0]). While most alterations were associated with a high androgen receptor signaling score, mutant SPOP was exclusively associated with a low median and interquartile range (IQR) androgen receptor signaling score (0.788 [IQR 0.765-0.791] versus 0.835 [IQR 0.828-0.842], P = .003). In mutant SPOP, mRNA expression of SPOP inhibitor G3BP1 and SPOP substrates showed a significantly decreased expression of AR (33.40 [IQR 28.45-36.30] versus 59.53 [IQR 53.10-72.83], P = .01), TRIM24 (3.95 [IQR 3.28-5.03] versus 9.80 [IQR 7.39-11.70], P = .008), and NCOA3 (15.19 [IQR 10.59-15.93] versus 21.88 [IQR 18.41-28.33], P = .046). Conclusions.--African American patients with metastatic prostate adenocarcinoma might have a higher prevalence of mutant SPOP (30%), compared to ~10% in unselected cohorts with lower expressions of SPOP substrates. In our study, in patients with mutant SPOP, the mutation was associated with decreased SPOP substrate expression and androgen receptor signaling, raising concern for suboptimal efficacy of androgen deprivation therapy in this subset of patients., Prostatic adenocarcinoma (PCa) is the third most common cancer in the United States, with approximately 1 in 9 men developing PCa during their lifetime. (1) At presentation, most PCas are [...]
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- 2024
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33. Immunohistochemistry Update in Dermatopathology and Bone and Soft Tissue Pathology
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Bourgeau, Melanie and Gardner, Jerad M.
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Medical research ,Medicine, Experimental ,Denosumab ,Immunohistochemistry ,Tumors -- Diagnosis ,Skin ,Health - Abstract
* Context.--Immunohistochemistry plays an important role in dermatopathology, particularly for melanocytic lesions and poorly differentiated malignancies. In the field of bone and soft tissue pathology, molecular methods remain the gold standard for diagnosis; however, immunohistochemistry targeting underlying molecular alterations represents a valuable screening tool, especially in areas with limited access to molecular testing. Objective.--To describe the utility and limitations of new and emerging immunohistochemical stains in the diagnosis of skin, soft tissue, and bone tumors. Data Sources.--A literature review of recently described immunohistochemical stains in the fields of dermatopathology and bone and soft tissue pathology was performed. Conclusions.--Immunohistochemistry is an important adjunctive tool for select entities in dermatopathology and bone and soft tissue pathology, and it provides pathologists with valuable evidence of their behavior, underlying molecular alterations, and line of differentiation. Furthermore, immunostains targeting molecular abnormalities have the potential to replace current molecular methods. Many of these recently described stains demonstrate higher sensitivity and specificity; however, limitations and pitfalls still exist, and correlation with morphologic and clinical findings remains essential for diagnosis., The hematoxylin-eosin stain is still the primary tool used by pathologists for the diagnosis of both neoplastic and nonneoplastic diseases in dermatopathology and bone and soft tissue pathology. However, the [...]
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- 2024
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34. Proceso Analítico Jerárquico Neutrosófico para la evaluación de los pacientes con Trombosis Venosa Profunda atendidos en el hospital IESS Ibarra
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Reyes Espinoza, Libia Karina, Mafla Herrería, César, and Sánchez Sandoval, Pamela Alexandra
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- 2024
35. Método para el control de los factores de riesgo del bruxismo que afectan a las piezas dentales de adolescentes ocasionados por estrés
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Guédez Mujica, Ana Graciela, García Novillo, Adriana María, Freire Villena, Diana Carolina, and Cevallos Naranjo, Doménica Nicole
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- 2024
36. Characterization of Cetacean Morbillivirus in Humpback Whales, Brazil
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de Amorim, Derek B., de Camargo, Laura J., Ribeiro, Paula R., Budaszewski, Renata da F., Menegatt, Jean Carlo O., Paz, Milena C., de Castro, Lucas T., Almeida, Paula R., Olegario, Juliana C., Canal, Claudio W., and Sonne, Luciana
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Medical research ,Medicine, Experimental ,Humpback whale -- Diseases ,Measles virus -- Identification and classification -- Distribution ,Host-virus relationships ,Company distribution practices ,Health - Abstract
The humpback whale (Megaptera novaeangliae) is a mysticete with a cosmopolitan distribution, including Brazil (1). Morbillivirus in cetaceans first occurred in 1988 in Europe. Since then, various strains of cetacean [...]
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- 2024
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37. Sporadic Occurrence of Ensitrelvir-Resistant SARS-CoV-2, Japan
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Doi, Akihiro, Ota, Masayuki, Saito, Masumichi, and Matsuyama, Shutoku
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Gene mutations -- Health aspects ,Medical research ,Medicine, Experimental ,Antiviral agents -- Patient outcomes ,Viral drug resistance -- Research ,Health - Abstract
Ensitrelvir fumaric acid (hereafter ensitrelvir) is a drug that inhibits the 3-chymotrypsin-like protease of SARS-CoV-2, also known as nonstructural protein 5 (NSP5), thereby inhibiting virus replication (1-3). Ensitrelvir was first [...]
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- 2024
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38. Foodborne Disease Outbreaks Linked to Foods Eligible for Irradiation, United States, 2009-2020
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Zlotnick, Marta, Eisenstein, Taylor, Robyn, Misha Park, and Marshall, Katherine E.
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Medical research ,Medicine, Experimental ,Foodborne diseases -- Risk factors ,Health - Abstract
Food irradiation has been studied globally for decades and is a safe, effective means of reducing foodborne illness-causing pathogens, sterilizing insects, delaying ripening or sprouting, and extending shelf life (2,2). [...]
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- 2024
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39. Evaluating Humoral Immunity Elicited by XBB.1.5 Monovalent COVID-19 Vaccine
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Nguyenla, Xammy Huu, Bates, Timothy A., Trank-Greene, Mila, Wahedi, Mastura, Tafesse, Fikadu G., and Curlin, Marcel E.
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Medical research ,Medicine, Experimental ,Immune response -- Observations ,Health - Abstract
A monovalent COVID-19 vaccine containing the XBB.1.5 variant SARS-CoV-2 spike protein was approved in September 2023, but uptake has been hesitant (1). Evaluating the immunogenicity of variant-adapted vaccines could inspire [...]
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- 2024
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40. Polycythemia vera and noncirrhotic portal hypertension diagnosed during pregnancy
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Frank, Cairina, Amily, Noor, Kelly, Erin, Kimpton, Miriam, Villeneuve, Pierre, and O'Meara, Paloma
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Medical research ,Alfacalcidol ,Pregnant women ,Obstetrics ,Liver cirrhosis ,Diagnostic imaging ,Aspirin ,Medicine, Experimental ,Pregnancy ,Diabetes therapy ,Calcifediol ,Vitamin D ,Liver ,Health - Abstract
A 35-year-old woman (gravida 2, para 0, miscarriage 1) at 30 weeks and 1 day gestation via in vitro fertilization was seen in consultation in our obstetric medicine clinic for [...]
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- 2024
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41. Managing 'socially admitted' patients in hospital: a qualitative study of health care providers' perceptions
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Mah, Jasmine C., Stilwell, Christie, Kubiseski, Madeline, Arora, Gaurav, Nicholls, Karen, Khan, Sheliza, Veinot, Jonathan, Eum, Lucy, Freter, Susan, Koller, Katalin, von Maltzahn, Maia, Rockwood, Kenneth, Searle, Samuel D., Andrew, Melissa K., and Marshall, Emily Gard
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Medical research ,Medicine, Experimental ,Health care industry ,Social workers ,Hospital patients ,Disease susceptibility ,Nurses ,Health care industry ,Company business management ,Health - Abstract
Background: Emergency departments are a last resort for some socially vulnerable patients without an acute medical illness (colloquially known as 'socially admitted' patients), resulting in their occupation of hospital beds typically designated for patients requiring acute medical care. In this study, we aimed to explore the perceptions of health care providers regarding patients admitted as 'social admissions.' Methods: This qualitative study was informed by grounded theory and involved semistructured interviews at a Nova Scotia tertiary care centre. From October 2022 to July 2023, we interviewed eligible participants, including any health care clinician or administrator who worked directly with 'socially admitted' patients. Virtual or in-person individual interviews were audio-recorded and transcribed, then independently and iteratively coded. We mapped themes on the 5 domains of the Quintuple Aim conceptual framework. Results: We interviewed 20 nurses, physicians, administrators, and social workers. Most identified as female (n = 11) and White (n = 13), and were in their mid to late career (n = 13). We categorized 9 themes into 5 domains: patient experience (patient description, provision of care); care team well-being (moral distress, hierarchy of care); health equity (stigma and missed opportunities, prejudices); cost of care (wait-lists and scarcity of alternatives); and population health (factors leading to vulnerability, system changes). Participants described experiences caring for 'socially admitted' patients, perceptions and assumptions underlying 'social' presentations, system barriers to care delivery, and suggestions of potential solutions. Interpretation: Health care providers viewed 'socially admitted' patients as needing enhanced care but identified individual, institutional, and system challenges that impeded its realization. Examining perceptions of the people who care for 'socially admitted' patients offers insights to guide clinicians and policy-makers in caring for socially vulnerable patients., Emergency departments have become a destination of last resort for some patients who are made vulnerable by social circumstances, resulting in their occupying hospital beds typically designated for people with [...]
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- 2024
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42. Experienced Clinical Decision-Making in Physical Therapist Management of Concussion: A Qualitative Study
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Galgon, Anne K. and Bliss, Rebecca A.
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Medical research ,Medicine, Experimental ,Brain -- Concussion ,Therapeutics, Physiological -- Methods ,Decision-making -- Methods ,Physical therapy -- Methods ,Physical therapists -- Beliefs, opinions and attitudes ,Health - Abstract
Objective. The recent publication of the Physical Therapy Evaluation and Treatment After Concussion Clinical Practice Guideline is intended to assist clinicians in their decision-making specific to evaluation and intervention. Clinical practice guidelines are supported by best available evidence, though it is unknown what other factors drive clinical decision-making in the realm of concussion management. The purpose of this study was to explore factors related to the process of clinical decision-making of experienced physical therapists who treat individuals with concussion. Methods. This grounded theory approach used semi-structured interviews of physical therapists who have practiced concussion management [greater than or equal to]3 years and have treated [greater than or equal to]15 individuals for postconcussion symptoms in the last year. Following the inductive approach, deductive qualitative methodology was used to explore alignment with recent guidelines. Member checking was used to ensure trustworthiness. Results. Ten therapists' experience in treating concussion ranged from 5 to 20 years. Four overarching themes were identified that contribute to clinical decision-making: expert practice behaviors through use of reflection in action, clinical reasoning, collaboration, and evidenced informed practice; therapeutic alliance building using individualized education, reassurance, and relationship building; adaptability in prioritizing, assessing, and responding to patients' needs; and listening and observing. Clinician decision-making statements showed alignment with clinical practice guideline recommendations. Conclusion. Experienced therapists demonstrate a consistent approach that parallels the current clinical practice guideline while building off clinical experience to tailor individualized care focusing on patient centeredness. These factors may assist more novice clinicians to develop and improve their management strategies for optimal outcomes. Impact. Identified themes may broaden frameworks and guidelines for the management of individuals postconcussion specific to the field of physical therapy. Keywords: Concussion, Decision-Making: Clinical, Physical Therapists, Introduction The lifetime prevalence of self-reported concussion is approximately 29% in adults (1) and 25% in adolescents. (2) Recent updates to the definition of concussion include an injury that occurs [...]
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- 2024
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43. Supervised Telerehabilitation and Home-Based Respiratory Muscle Training for Post--COVID-19 Condition Symptoms: A Nested Qualitative Study Exploring the Perspectives of Participants in a Randomized Controlled Trial
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Palacios-Cena, Domingo, Bautista-Villaecija, Oscar, Gueita-Rodriguez, Javier, Garcia-Bravo, Cristina, Perez-Corrales, Jorge, Del Corral, Tamara, Lopez-de-Uralde-Villanueva, Ibai, Fabero-Garrido, Raul, and Plaza-Manzano, Gustavo
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Medical research ,Medicine, Experimental ,Home care -- Methods ,Rehabilitation -- Methods -- Technology application ,Telemedicine -- Usage ,Breathing exercises -- Methods -- Physiological aspects ,Respiratory muscles -- Physiological aspects ,Technology application ,Health - Abstract
Objective. The purpose of this study was to describe the experiences of individuals with post-coronavirus 19 (COVID-19) condition symptoms who underwent a supervised telerehabilitation and home-based respiratory muscle training (TSHB-RMT) program. Methods. A qualitative descriptive study was conducted. Participants were recruited using purposeful sampling. The inclusion criteria consisted of: patients aged over 18 years who presented persistent COVID-19 symptoms of fatigue and dyspnea for at least 3 months after the COVID-19 diagnosis. In total, 28 patients were included. In-depth interviews and researcher field notes were used to collect the data. A thematic analysis was performed. Results. Three themes reflect the patients' perspective on the TSHB-RMT before the program (reasons for participating), during the treatment program, and upon completion of the study. Among the reasons for participation, participants highlighted the absence of improvement and treatment, and feeling abandoned and forgotten by the health system. The treatment required discipline on behalf of the patients. Mondays and Tuesdays were the most difficult days for performing the therapy, and the physical therapist was perceived as a tool for adherence, change, and a source of validated information. The patients perceived positive effects quite soon; however, it was necessary to extend the follow-up after completing the program because they abandoned the program due to the lack of guidance for exercise supervision. Conclusion. This study described relevant aspects that physical therapist professionals should consider when providing TSHB-RMT treatment. Impact. TSHB-RMT requires discipline, perseverance, effort, and a commitment to the group. The physical therapist is perceived as the tool that facilitates adherence and participation. The effects are rapidly perceived, leading to improved self-confidence and autonomy; however, it is necessary to increase the follow-up time. Keywords: (MeSH): Breathing Exercises, Physical Therapists, Postacute COVID-19 Syndrome, Qualitative Research, SARS-CoV-2, Telerehabilitation, Introduction After COVID-19 infection, between 2.3% and 60% of survivors experience symptoms that are unexplained by an alternative diagnosis. (1,2) These individuals are considered to have post-COVID-19 condition (PCC) when [...]
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- 2024
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44. Minimal Clinically Important Difference of the Disabilities of the Arm, Shoulder and Hand (DASH) and the Shortened Version of the DASH (QuickDASH) in People With Musculoskeletal Disorders: A Systematic Review and Meta-Analysis
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Galardini, Orenzo, Coppari, Andrea, Pellicciari, Leonardo, Ugolini, Alessandro, Piscitelli, Daniele, Porta, Fabio La, Bravini, Elisabetta, and Vercelli, Stefano
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Medical research ,Medicine, Experimental ,Health status indicators -- Comparative analysis -- Evaluation ,Musculoskeletal diseases -- Evaluation -- Physiological aspects ,Health - Abstract
Objective. The objective of this study was to perform a meta-analysis of the minimal clinically important difference (MCID) of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and its shortened version (ie, the QuickDASH). Methods. MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science, Cochrane Library, and Scopus were searched up to July 2022. Studies on people with upper limb musculoskeletal disorders that calculated the MCID by anchor-based methods were included. Descriptive and quantitative synthesis was used for the MCID and the minimal detectable change with 90% confidence ([MDC.sub.90]). Fixed-effects models and random-effect models were used for the meta-analysis. [I.sup.2] statistics was computed to assess heterogeneity. The methodological quality of studies was assessed with the Consensus-Based Standards for the Selection of Health Measurement Instruments checklist for measurement error and an adaptation of the checklist for the studies on MCID proposed by Bohannon and Glenney. Results. Twelve studies (1677 patients) were included, producing 17 MCID estimates ranging from 8.3 to 18.0 DASH points and 8.0 to 18.1 QuickDASH points. The pooled MCIDs were 11.00 DASH points (95% CI = 8.59-13.41; [I.sup.2] = 0%) and 11.97 QuickDASH points (95% CI = 9.60-14.33; [I.sup.2] = 0%). The pooled [MDC.sub.90]s were 9.04 DASH points (95% CI = 6.46-11.62; [I.sup.2] = 0%) and 9.03 QuickDASH points (95% CI = 6.36-11.71; [I.sup.2] = 18%). Great methodological heterogeneity in the calculation of the MCID was identified among the primary studies. Conclusion. Reasonable MCID ranges of 12 to 14 DASH points and 12 to 15 QuickDASH points were established. The lower boundaries represent the first available measure above the pooled [MDC.sub.90], and the upper limits represent the upper 95% CI of the pooled MCID. Impact. Reasonable ranges for the MCID of 12 to 14 DASH points and 12 to 15 QuickDASH points were proposed. The lower boundaries represent the first available measure above the pooled [MDC.sub.90], and the upper limits represent the upper 95% CI of the pooled MCID. Information regarding the interpretability of the 2 questionnaires was derived from very different methodologies, making it difficult to identify reliable thresholds. Now clinicians and researchers can rely on more credible data. The proposed MCIDs should be used to assess people with musculoskeletal disorders. Heterogeneity was found related particularly to the anchor levels used in the primary studies. To promote comparability of MCID values, shared rules defining the most appropriate types of anchoring will be needed in the near future. Keywords: Clinical Relevance, Minimal Detectable Change, Patient Reported Outcome Measures, Psychometrics, Responsiveness, Upper Extremity, Introduction Health outcome measures are relevant to clinicians to select the most suitable treatment option, establish customized goals, and examine the effectiveness of an intervention. Patient-reported outcome measures (PROMs) are [...]
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- 2024
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45. Trunk Muscle Function and Core Stability in Women Who Had Muscle-Sparing Pedicled Transverse Rectus Abdominis Myocutaneous Flap Breast Reconstruction
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Liaw, Lih-Jiun, Hsiao, Shih-Fen, and Hsu, Ar-Tyan
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Women -- Health aspects ,Medical research ,Medicine, Experimental ,Abdomen -- Muscles ,Mammaplasty -- Methods -- Physiological aspects ,Health - Abstract
Objective. The long-term effects of the unilateral muscle-sparing pedicled transverse rectus abdominis myocutaneous (TRAMmsp) flap procedure on trunk muscle performances and core stability were investigated in women with breast cancer. Methods. Forty women (mean age = 42.6 years) who had received breast reconstruction with the unilateral TRAMmsp flap procedure no less than 6 months earlier (mean = 10.3 [standard deviation, SD = 4.9] months) (TRAM group) participated, and 30 women who were healthy and matched for age (mean age = 41.2 years) served as controls (control group). Their abdominal and back muscle strength was assessed using the curl-up and prone extension tests, respectively, and their static abdominal muscle endurance and back extensor endurance were assessed using the sit-up endurance test in the crook-lying position and the Biering-Sorensen test, respectively. Core stability strength was assessed using a 4-level limb-lowering test (abdominal muscle test), and core stability endurance was assessed while lying supine with both flexed legs 1 inch off the mat while keeping the pelvis in a neutral position with a pressure biofeedback unit. Results. Compared with the control group, trunk muscles of the TRAM group were weaker, showing less endurance, as were their core stability strength and endurance. Static trunk muscle endurances and trunk flexion strength were associated with core stability in both groups. Conclusions. Women exhibit trunk flexor and extensor weakness along with poor endurance and impaired core stability even after an average of 10 months from receiving the TRAMmsp flap procedure. Immobilization after surgery, with possible systemic inflammatory effects from surgery and chemotherapy, might have further contributed to the generalized weakness subsequent to the partial harvesting of the rectus abdominis. Impact. Women after breast reconstruction with the TRAMmsp flap procedure show long-lasting deficits of strength and endurance in abdominal muscles, back extensors, and core stability. Proactive measures including early detection and evaluation of impairments as well as timely intervention targeting these clients are important to minimize the dysfunction and support their return to community participation. Keywords: Core Stability, Muscle-Sparing Pedicled TRAM Flap Breast Reconstruction, Rectus Abdominis, Trunk Muscle Function, Introduction Pedicled transverse rectus abdominis myocutaneous (TRAM) flap surgery is a popular surgical option for autologous breast reconstruction in women with breast cancer, (1-3) involving transecting the rectus abdominis at [...]
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- 2024
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46. Introducing Mechanically Assisted Cough for Patients With Progressive Neurological Disease: Patient-Physical Therapist Interaction and Physical Therapist Perspective
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Andersson-Watz, Anna, Nygren-Bonnier, Malin, Bergdahl, Elisabeth, Crommert, Martin Eriksson, and Svantesson, Mia
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Therapist and patient -- Research ,Cough -- Management ,Medical equipment -- Usage -- Social aspects ,Medical research ,Medicine, Experimental ,Nervous system diseases -- Care and treatment -- Physiological aspects ,Psychotherapist and patient -- Research ,Physiological apparatus -- Usage -- Social aspects ,Physical therapists -- Beliefs, opinions and attitudes ,Company business management ,Health - Abstract
Objective. The goal of this study was to explore the patient-physical therapist interaction and the physical therapist's experience of the introductory session for mechanical insufflation-exsufflation (Ml-E) device treatment for patients with progressive neurological disease. Methods. Qualitative content analysis of participant's observation of interaction between patients and physical therapists during 9 Ml-E introduction sessions in different clinical care settings and 10 follow-up interviews with 6 physical therapists. Results. The introduction of Ml-E emerged as a process of instilling a sense of security in the patient. The process can be described in 4 steps: (1) gain understanding by being responsive to the person's whole life situation; (2) share knowledge and expectations in a respectful and permissive way; (3) introduce the device in a gentle and reciprocal interactivity; and (4) adapt to home use in an inclusive dialog with the patient and their significant others. Physical therapists described a need for assurance to instill a sense of security in the patient, implying a need for confidence, competent peers, guiding yet flexible routines, and emotional support. Conclusion. Physical therapists have a need to foster assurance in employing a person-centered approach to make a patient feel secure in the process of introducing Ml-E treatment. Multiple modes of professional knowledge were used together with action-based and relational-based ethics to facilitate a person-centered care approach. This seems to be a promising approach for providing good care when introducing Ml-E to patients. Further research is needed to explore this from the patient's perspective. Impact. This study added to the body of knowledge regarding Ml-E treatment in relation to patients. This has direct implication, particularly for inexperienced physical therapists, for informed care for the patient during introduction. Our study also supports that person-centered care should be implemented at all levels of health care to make it possible for physical therapists to practice person-centered care. Keywords: Mechanical Insufflation--Exsufflation, Neuromuscular Disease, Physical Therapy, Qualitative, Introduction Patients affected by progressive neurological disease in the later stages are prone to pulmonary complications, (1) characterized by impaired ventilation and cough, which can increase morbidity and mortality. (2) [...]
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- 2024
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47. Treatment of Women With Primary Dysmenorrhea With Manual Therapy and Electrotherapy Techniques: A Systematic Review and Meta-Analysis
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Gonzalez-Mena, Angela, Leiros-Rodriguez, Raquel, and Hernandez-Lucas, Pablo
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Women -- Health aspects ,Medical research ,Medicine, Experimental ,Therapeutics, Physiological -- Methods -- Physiological aspects -- Patient outcomes ,Physical therapy -- Methods -- Physiological aspects -- Patient outcomes ,Electrotherapeutics -- Methods -- Physiological aspects -- Patient outcomes ,Dysmenorrhea -- Care and treatment ,Health - Abstract
Objective. The objective of this study was to evaluate the efficacy of electrotherapy and manual therapy for the treatment of women with primary dysmenorrhea. Methods. Systematic searches were conducted in Scopus, Web of Science, PubMed, CINAHL, and MEDLINE. The articles must have been published in the last 10 years, had a sample exclusively of women with primary dysmenorrhea, had a randomized controlled trial design, and used interventions that included some form of manual therapy and/or electrotherapy techniques. Two reviewers independently screened articles for eligibility and extracted data. Difference in mean differences and their 95% CIs were calculated as the between-group difference in means divided by the pooled standard deviation. The [I.sup.2] statistic was used to determine the degree of heterogeneity. Results. Twelve selected studies evaluated interventions, with 5 evaluating electrotherapy techniques and 7 evaluating manual therapy techniques. All studies analyzed identified improvements in pain intensity and meta-analysis confirmed their strong effect. Conclusions. Manual therapy and electrotherapy are effective for the treatment of women with primary dysmenorrhea. Transcutaneous electrical nerve stimulation combined with thermotherapy and effleurage massage stands out for its effects on the intensity and duration of pain with the application of a few sessions and their long-term effects. Impact. Manual therapy techniques and electrotherapy methods reduce the pain intensity of women with primary dysmenorrhea. Quality of life and degree of anxiety improved significantly with manual therapy interventions. Transcutaneous electrical nerve stimulation combined with thermotherapy and effleurage massage are the interventions with which positive effects were achieved with fewer sessions. Keywords: Dysmenorrhea, Electric Stimulation Therapy, Manual Therapy, Physical Therapy Modalities, Physical Therapy Specialty, Introduction Dysmenorrhea is a menstrual disorder characterized by suprapubic cramping of uterine origin and pain occurring a few hours before or after the onset of menstruation. (1) Dysmenorrhea is classified, [...]
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- 2024
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48. EXPLORE University of Florida Research
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International Space Station (Space station) ,Medical research ,Medicine, Experimental ,Space stations -- Research ,Business ,Business, regional ,University of Florida - Abstract
In the following pages, you'll see how the latest discoveries from the University of Florida are moving Florida forward. UF's scientists and scholars will share creative approaches to the python [...]
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- 2024
49. HELLO, DR. ROBOTO: AI is here, and it's got gigantic potential to bring us more accurate diagnoses and treatments, lead to better patient care, and even predict future pandemics. It also may dehumanize health care in ways that could be hard to control. Read on to find out what things may look like in the coming years
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Landau, Meryl Davids
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Patients -- Care and treatment ,Medical research ,Medicine, Experimental ,Artificial intelligence ,Physicians ,Artificial intelligence ,Health ,Sports and fitness - Abstract
IN THE 1960s, viewers of TV's Star Trek were amazed when Dr. Leonard 'Bones' McCoy scanned a patient's body using a handheld 'tricorder' device whose artificial intelligence (AI) quickly generated [...]
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- 2024
50. Diagnostic et prise en charge de l'oesophagite a eosinophiles
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Gupta, Milli and Grinman, Michelle
- Subjects
Medical research ,Medicine, Experimental ,Esophagitis -- Diagnosis -- Care and treatment ,Eosinophils -- Health aspects ,Health - Abstract
L'oesophagite a eosinophiles est une maladie chronique qui peut affecter autant les enfants que les adultes et qui englobe divers problemes, car il s'agit d'une cause frequente de dysphagie oesophagienne, [...]
- Published
- 2024
- Full Text
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