Minimal Clinically Important Difference of the Disabilities of the Arm, Shoulder and Hand (DASH) and the Shortened Version of the DASH (QuickDASH) in People With Musculoskeletal Disorders: A Systematic Review and Meta-Analysis

Objective. The objective of this study was to perform a meta-analysis of the minimal clinically important difference (MCID) of the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire and its shortened version (ie, the QuickDASH). Methods. MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science, Cochrane Library, and Scopus were searched up to July 2022. Studies on people with upper limb musculoskeletal disorders that calculated the MCID by anchor-based methods were included. Descriptive and quantitative synthesis was used for the MCID and the minimal detectable change with 90% confidence ([MDC.sub.90]). Fixed-effects models and random-effect models were used for the meta-analysis. [I.sup.2] statistics was computed to assess heterogeneity. The methodological quality of studies was assessed with the Consensus-Based Standards for the Selection of Health Measurement Instruments checklist for measurement error and an adaptation of the checklist for the studies on MCID proposed by Bohannon and Glenney. Results. Twelve studies (1677 patients) were included, producing 17 MCID estimates ranging from 8.3 to 18.0 DASH points and 8.0 to 18.1 QuickDASH points. The pooled MCIDs were 11.00 DASH points (95% CI = 8.59-13.41; [I.sup.2] = 0%) and 11.97 QuickDASH points (95% CI = 9.60-14.33; [I.sup.2] = 0%). The pooled [MDC.sub.90]s were 9.04 DASH points (95% CI = 6.46-11.62; [I.sup.2] = 0%) and 9.03 QuickDASH points (95% CI = 6.36-11.71; [I.sup.2] = 18%). Great methodological heterogeneity in the calculation of the MCID was identified among the primary studies. Conclusion. Reasonable MCID ranges of 12 to 14 DASH points and 12 to 15 QuickDASH points were established. The lower boundaries represent the first available measure above the pooled [MDC.sub.90], and the upper limits represent the upper 95% CI of the pooled MCID. Impact. Reasonable ranges for the MCID of 12 to 14 DASH points and 12 to 15 QuickDASH points were proposed. The lower boundaries represent the first available measure above the pooled [MDC.sub.90], and the upper limits represent the upper 95% CI of the pooled MCID. Information regarding the interpretability of the 2 questionnaires was derived from very different methodologies, making it difficult to identify reliable thresholds. Now clinicians and researchers can rely on more credible data. The proposed MCIDs should be used to assess people with musculoskeletal disorders. Heterogeneity was found related particularly to the anchor levels used in the primary studies. To promote comparability of MCID values, shared rules defining the most appropriate types of anchoring will be needed in the near future. Keywords: Clinical Relevance, Minimal Detectable Change, Patient Reported Outcome Measures, Psychometrics, Responsiveness, Upper Extremity
Introduction Health outcome measures are relevant to clinicians to select the most suitable treatment option, establish customized goals, and examine the effectiveness of an intervention. Patient-reported outcome measures (PROMs) are [...]