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Experiments performed on mice C57Bl/6 with the use of GFP technology showed that activation of apoptosis is a potent physiological stimulus for targeted migration of mesenchymal stem cell from the blood to tissues. The effect of apoptosis-induced targeted migration of stem cells can be used in cell therapy of damaged organs and tissues in various pathological states.

We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used for the therapy of burns, wounds, and purulent and inflammatory diseases on spontaneous and induced synthesis of tumor necrosis factor and interleukins 1, 2, and 8 by human peripheral blood neutrophils in vitro. These preparations contain various bioactive substances producing opposite and dose-dependent immunomodulatory effects. Our results indicate that the composition and doses of preparations should be selected to achieve the maximum therapeutic effect.

We studied the effects of water-soluble fractions of pine resin and Biopin-10 and Biopin-20 ointments used in the treatment of burns, wounds, and pyoinflammatory processes on the phagocytic activity and redox potential of human peripheral blood neutrophils in vitro. The test preparations contain bioactive substances producing opposite dose-dependent effects on phagocytosis, which suggests that the composition and dose of ointments should be selected individually in order to attain the optimal therapeutic effect.

We studied the effects of Biopin ointment containing pine resin and used for the therapy of burns, wounds, and purulent and inflammatory diseases on the cell composition of wounds and histochemical changes in the granulation tissue during the therapy of extensive third-degree burns. The preparation stimulated the nonspecific immune response, normalized hemodynamics in damaged regions, and stimulated cell proliferation in the squamous epithelium.

We studied properties of ointment Biopin containing pine resin and used for the therapy of burns, wounds, and purulent and inflammatory diseases. Long-term treatment with this preparation in clinical doses had no effect on the nonspecific, but modulated the specific immune response. Biopin ointment inhibited humoral, but stimulated cell immunity. Neither local irritation, nor allergic reactions were found after long-term epicutaneous application of the preparation.

We studied the effects of pine resin and Biopin ointment used for the therapy of burns, wounds, purulent and inflammatory diseases on the content of lipid peroxidation products, including primary (conjugated dienes), secondary (malonic dialdehyde and ketodienes), and end products (Schiff bases), and content of isolated double bonds in the spleen and liver. Repeated application of Biopin did not modulate lipid peroxidation. The inhibitory effect of this preparation was observed only in the initial short period after application.

We studied the effects of pine resin and Biopin ointment used for the therapy of burns, wounds, purulent and inflammatory diseases on blood leukocyte count, phagocytic activity of macrophages and neutrophils, and redox potential of peripheral blood neutrophils. The wound-healing effect of the test preparations is determined by their ability to activate phagocytosis.

We studied the effects of pine resin and Biopin ointment used for the therapy of burns, wounds, purulent and inflammatory diseases on differentiation of T lymphocyte precursors, lymphocyte proliferation in the thymus and spleen, and production of tumor necrosis factor and interleukins 1, 2, and 6 by splenocytes and peripheral blood leukocytes. The wound-healing effect of these preparations is determined by their pronounced immunomodulatory properties.