1. CD28 and ITK signals regulate autoreactive T cell trafficking
- Author
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Jain, Nitya, Miu, Bing, Jiang, Jian-kang, McKinstry, Kai K., Prince, Amanda, Swain, Susan L., Greiner, Dale L., Thomas, Craig J., Sanderson, Michael J., Berg, Leslie J., and Kang, Joonsoo
- Subjects
Tyrosine -- Genetic aspects ,T cells -- Properties ,Autoimmunity -- Research ,Clusters (Chemistry) -- Research ,Protein kinases -- Properties ,Cellular control mechanisms -- Research ,Biological sciences ,Health - Abstract
Activation of self-reactive T cells and their trafficking to target tissues leads to autoimmune organ destruction. Mice lacking the co-inhibitory receptor cytotoxic T lymphocyte antigen-4 (CTLA-4) develop fatal autoimmunity characterized [...]
- Published
- 2013
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